CN1840106A - Medicine for treating chronic hepatitis B and its preparation method - Google Patents
Medicine for treating chronic hepatitis B and its preparation method Download PDFInfo
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- CN1840106A CN1840106A CNA2006100123740A CN200610012374A CN1840106A CN 1840106 A CN1840106 A CN 1840106A CN A2006100123740 A CNA2006100123740 A CN A2006100123740A CN 200610012374 A CN200610012374 A CN 200610012374A CN 1840106 A CN1840106 A CN 1840106A
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Abstract
The invention relates to a Chinese medicinal composition for treating chronic hepatitis B, which is prepared from astragalus root, cattail pollen, trogopterus dung, notoginseng, cogongrass rhizome, buffalo horn concentrated powder, kudzu vine root, haw thorn through boiling, concentrating, drying and loading into capsules.
Description
Affiliated technical field
The present invention relates to a kind of medicine, particularly relate to a kind of Chinese patent medicine for the treatment of chronic hepatitis B.The invention still further relates to the preparation method of this medicine.
Background technology
Hepatitis B is that a kind of spread speed is fast, scope is wide, the frequently-occurring disease of serious harm people ' s health, commonly encountered diseases.In recent years, Chinese scholars has been done a large amount of research to this, though obtained some progress, but still have some problems, mainly show as most curative effect of medication uncertainly, DeGrain; Can not remove viral infection, easily recurrence after the drug withdrawal; Some chemical synthetic drugs and price costlinesses such as biochemical preparation such as interferon, transfer factor, the patient generally is difficult to accept.
Chronic hepatitis B belongs to the category of cards such as motherland's medical science jaundice, hypochondriac pain, vomiting, syndrome of feeling fullness and distension in the upper abdomen.Its diseased region is many mostly to be and to experience seasonal pathogen epidemic disease poison at the liver and gall taste, and burnt in the strongly fragrant resistance, transporting and transforming function of the spleen and stomach is not normal; Or eating and drinking without temperance, be addicted to drink excessively impairing the spleen and stomach, damp and hot strongly fragrant resistance liver and gall; Or feelings will is hindered initiations such as angry impairing the liver.Though it is various that the etiology and pathology of chronic hepatitis B changes, syndrome of blood stasis due to qi deficiency is its common, multiple clinical onset type.Taste are the foundation of acquired constitution, source of generating QI and blood, and disease is of a specified duration or mistake rule of treatment taste are impaired, a little less than the middle deficiency of vital energy, the dereliction of duty of the fortune function of spleen, middle burnt mechanism of qi is mediated not normal, venation stasis; Deficiency of spleen-QI, the precise and tiny then lassitude of the limbs and weakness of extremity that makes moist of unable transporting and transforming nutrients from foodstuff; Taste void, digesting food are had no right then inappetence, and adverse rising of stomach-QI is nausea and vomiting then.Qi as the commander of blood, blood circulation depending on qi flow, blood stored in the liver, main catharsis, gallbladder is the fu-viscera with decisive character, stores and catharsis bile, liver and gall are coordinated mutually.Blood, deficiency of liver-QI are regulated the capable unable then hematogenous blockage of blood if deficiency of spleen-QI can not be united, the blood stasis liver and gall, and the bile flowing outside the biliary passages and excessive causes skin, yellow sclera.This is the card of deficiency in origin and excess in superficiality, controls and works as strengthening QI of middle-JIAO, makes the strong fortune of taste, and QI and blood biochemistry is active, the healthy energy abundance, and blood fortune is strong, and blood vessels are unimpeded; Invigorate blood circulation with the power of blood stasis dispelling walk help blood, it is hot and suffocating to loose for removing heat from blood, and the liver and gall blood stasis eliminates then that bile can follow Chang Dao and yellow from going.Therefore, treatment should be with the QI invigorating the lucid yang sending up, and blood circulation promoting and blood stasis dispelling is main.
Summary of the invention
The purpose of this invention is to provide a kind of benefiting QI for activating blood circulation, the treatment chronic hepatitis B medicine of clearing away heat-damp and promoting diuresis, this medicine are suitable for card and belong to blood stasis due to qi deficiency, damp and hot stagnation person.
The preparation method of this medicine is provided, and is another goal of the invention of the present invention.
Medicine of the present invention specifically is to be made by following materials based on weight:
The Radix Astragali 30～50 Pollen Typhaes 15～30
Oletum Trogopterori 15～30 Radix Notoginseng 1～5
Rhizoma Imperatae 15～30 Pulvis Cornus Bubali Concentratuss 1～5
Radix Puerariae 30～50 Fructus Crataegis 30～50.
The medicine of above-mentioned each component can be made said dosage form on any pharmaceutics, and the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made medicine of the present invention may further comprise the steps:
Getting Radix Notoginseng powder, to be broken into fine powder standby;
The Radix Astragali is decocted with water with Radix Puerariae, and Rhizoma Imperatae decocts with water with Oletum Trogopterori, and Fructus Crataegi decocts with water alone, obtains three kinds of decocting liquids respectively;
Merge above-mentioned three kinds of decocting liquids, filter, filtrate is concentrated into the thick paste of relative density 1.30～1.35 (80 ℃);
Pulvis Cornus Bubali Concentratus, Pollen Typhae and Radix Notoginseng fine powder are joined in the above-mentioned thick paste, mixing, drying is pulverized, and makes capsule in incapsulating.
Wherein, the Radix Astragali and Radix Puerariae are decocted with water three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time; Rhizoma Imperatae and Oletum Trogopterori are decocted with water secondary, 3 hours for the first time, 1.5 hours for the second time; Fructus Crataegi is decocted with water secondary, each 40 minutes.
In the prescription of the present invention, the sweet tepor of the Radix Astragali, tonifying Qi and lifting yang, " mend husband deficient, five kinds of over strain weakness and emaciation, QI invigorating " goes into spleen channel, continuous source of generating QI and blood, the mediation ascending or descending movement of vital Qi is thought monarch drug, but also invigorating spleen for diuresis detumescence, " not record " calls " Li Yin gas ".Pollen Typhae is sweet flat, blood circulation promoting and blood stasis dispelling, " main trusted subordinate's cold and heat, hemostasis, repercussive blood ", " invigorate blood circulation, end all pains of trusted subordinate "; The salty temperature of Oletum Trogopterori, the dissipating blood stasis relieving accumulation of pathogens, " can promoting the circulation of blood hemostasis, control cards such as pricking caused by the stagnation of QI and blood ", and both close is SHIXIAO SAN, blood circulation promoting competent silt, and removing obstruction for relieving pain reaches the liver and gall jaundice eliminating to dredge, and is ministerial drug.The sweet temperature of Radix Notoginseng, promoting blood circulation to remove blood stasis not only, anastalsis is good again, i.e. and " stasis of blood is not stayed in hemostasis " is with the power of strengthening invigorating blood circulation; Rhizoma Imperatae is sweet cold, and heat clearing and blood cooling is strongly fragrant with the sun that removes blood stasis, again can " main impairment caused by overstrain weakness with emaciation, invigorating the spleen and replenishing QI, diuresis ", " edema, jaundice "; Cornu Bubali has the class Cornu rhinocerotis, but effect is more slow, and heat clearing and blood cooling is controlled " jaundice "; Fructus Crataegi goes into liver taste warp, and one can strengthen the power of blood circulation promoting and blood stasis dispelling, but a strengthening the spleen and stomach help digestion and help the merit of becoming thoroughly decomposed, i.e. " dissipating fluid-retention food, the meat that disappears is long-pending, lump in the abdomen, phlegm retention ", four flavors are adjuvant drug altogether.Radix Puerariae is sweet hot cool, rises and sends out middle-jiao yang, function of the spleen and stomach, inspires QI of the spleen and stomach, and stopping vomiting is told, and separates all poison, and messenger drug is thought in the resolving depression heat radiation.All medicine compatibilities must be mended the deficiency of vital energy, and blood stasis must remove, and reaches the merit of benefiting QI for activating blood circulation; Blood circulation depending on qi flow, the positive stagnation of the blood is hot clearly, the strong fortune of taste, suffocating of liver and gall is as usual, and jaundice is from removing, and QI and blood is with smooth, and all kinds of diseases and ailments are to disappear.So the present invention has benefiting qi and raising yang, blood circulation promoting and blood stasis dispelling, the function of jaundice eliminating.
Medicine clearing away heat-damp and promoting diuresis of the present invention has benefiting QI for activating blood circulation, reducing enzyme and treating jaundice, and the regulation and control immunity improves proteic function, is applicable to that chronic hepatitis B belongs to blood stasis due to qi deficiency, damp and hot stagnation card person.
For further investigating the clinical efficacy and the safety of medicine of the present invention, the 302nd hospital of PLA has carried out clinical observation to the curative effect of Drug therapy chronic hepatitis B of the present invention.
Viewing test selects to meet inpatient 58 examples of following case choice criteria altogether:
1, the course of disease is more than half a year, and the age is more than 13 years old;
2, glutamate pyruvate transaminase (GPT), thymol turbidity test (TTT), bilirubin (BiL), blood plasma white/four of globulin (A/G) in binomial above unusual;
3, hepatitis B virus (HBV) labelling: HBsAg, HBeAg, anti--HBc, IgM anti--four of HBc in binomial above positive.
Therapeutic Method is oral medicine of the present invention, and 3 times on the one, each 6,3 months is 1 course of treatment, but effective case proper extension, and biochemical indicator continues the half a year of taking medicine after often or substantially again often leaving hospital again, to consolidate curative effect.
Check patient's biochemical indicator and HBV index during treating, and the statistical indicator situation of change is as follows.
Table 1 is taken changes of biochemical indexes situation behind the medicine of the present invention
| Index | Unusual routine number | Multiple normal (n) % | Effective (n) % | Invalid (n) % | Worsen (n) % | Total effective rate % |
| GPT | 58 | 38(65.52) | 10(17.24) | 7(12.07) | 3(5.17) | 82.76 |
| TTT | 48 | 2(4.17) | 15(31.25) | 31(64.58) | - | 35.42 |
| BiL | 48 | 33(68.75) | 5(10.42) | 10(20.83) | - | 79.17 |
| A/G | 31 | 19(61.29) | 4(12.90) | 8(25.81) | - | 74.19 |
Table 2 is taken HBV index situation of change behind the medicine of the present invention
| Index | Unusual routine number | Multiple normal (n) % | Effective (n) % | Total effective rate % |
| HBsAg | 55 | 2(3.64) | 6(10.91) | 14.55 |
| HBeAg | 4 | 4(100) | - | 100 |
| Anti--HBc | 52 | 1(1.92) | 18(34.62) | 36.54 |
| IgM resists-HBc | 37 | 23(62.16) | 3(8.11) | 70.27 |
Clinical test results proves that enzyme falls in medicine of the present invention, the jaundice eliminating effect is obvious, the anti-HBC negative conversion rate of IgM-height, and treatment chronic hepatitis B effect is remarkable, and the knock-on rate is low, safe and effective after taking, and has no side effect.
The specific embodiment
Embodiment 1:
Take by weighing raw material (Kg) by following proportioning:
The Radix Astragali 50 Pollen Typhaes 20
Oletum Trogopterori 20 Radix Notoginseng 2
Rhizoma Imperatae 20 Pulvis Cornus Bubali Concentratuss 2
Radix Puerariae 50 Fructus Crataegis 50.
Concrete preparation method is to get the 2.5Kg Radix Notoginseng powder to be broken into fine powder standby; Get each 50Kg mixing of the Radix Astragali and Radix Puerariae, decoct with water three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, decocting liquid is mixed stand-by; Get each 25Kg mixing of Rhizoma Imperatae and Oletum Trogopterori, decoct with water secondary, 3 hours for the first time, 1.5 hours for the second time, mix the secondary decocting liquid; Get the 50Kg Fructus Crataegi and decoct with water secondary, each 40 minutes; Merge above-mentioned three kinds of decocting liquids, filter, filtrate is concentrated into the thick paste of relative density 1.30～1.35 (80 ℃); 2.5Kg Pulvis Cornus Bubali Concentratus, 25Kg Pollen Typhae and 2.5Kg Radix Notoginseng fine powder are joined respectively in the above-mentioned thick paste, mixing, drying is pulverized, and makes capsule in incapsulating.
Embodiment 2:
Take by weighing raw material (Kg) by following proportioning:
The Radix Astragali 30 Pollen Typhaes 15
Oletum Trogopterori 15 Radix Notoginseng 5
Rhizoma Imperatae 15 Pulvis Cornus Bubali Concentratuss 5
Radix Puerariae 30 Fructus Crataegis 30.
Concrete preparation method is, getting the 5Kg Radix Notoginseng powder, to be broken into fine powder standby; Get each 30Kg mixing of the Radix Astragali and Radix Puerariae, decoct with water three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, decocting liquid is mixed stand-by; Get each 15Kg mixing of Rhizoma Imperatae and Oletum Trogopterori, decoct with water secondary, 3 hours for the first time, 1.5 hours for the second time, mix the secondary decocting liquid; Get the 30Kg Fructus Crataegi and decoct with water secondary, each 40 minutes; Merge above-mentioned three kinds of decocting liquids, filter, filtrate is concentrated into the thick paste of relative density 1.30～1.35 (80 ℃); 5Kg Pulvis Cornus Bubali Concentratus, 15Kg Pollen Typhae and 5Kg Radix Notoginseng fine powder are joined respectively in the above-mentioned thick paste, mixing, drying is pulverized, and makes capsule in incapsulating.
Embodiment 3:
Take by weighing raw material (Kg) by following proportioning:
The Radix Astragali 50 Pollen Typhaes 30
Oletum Trogopterori 30 Radix Notoginseng 3
Rhizoma Imperatae 30 Pulvis Cornus Bubali Concentratuss 3
Radix Puerariae 50 Fructus Crataegis 50.
Concrete preparation method is, getting the 3Kg Radix Notoginseng powder, to be broken into fine powder standby; Get each 50Kg mixing of the Radix Astragali and Radix Puerariae, decoct with water three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, decocting liquid is mixed stand-by; Get each 30Kg mixing of Rhizoma Imperatae and Oletum Trogopterori, decoct with water secondary, 3 hours for the first time, 1.5 hours for the second time, mix the secondary decocting liquid; Get the 50Kg Fructus Crataegi and decoct with water secondary, each 40 minutes; Merge above-mentioned three kinds of decocting liquids, filter, filtrate is concentrated into the thick paste of relative density 1.30～1.35 (80 ℃); 3Kg Pulvis Cornus Bubali Concentratus, 30Kg Pollen Typhae and 3Kg Radix Notoginseng fine powder are joined respectively in the above-mentioned thick paste, mixing, drying is pulverized, and makes capsule in incapsulating.
Embodiment 4:
Take by weighing raw material (Kg) by following proportioning:
The Radix Astragali 40 Pollen Typhaes 30
Oletum Trogopterori 30 Radix Notoginseng 2
Rhizoma Imperatae 30 Pulvis Cornus Bubali Concentratuss 2
Radix Puerariae 40 Fructus Crataegis 40.
Concrete preparation method is, getting the 2Kg Radix Notoginseng powder, to be broken into fine powder standby; Get each 40Kg mixing of the Radix Astragali and Radix Puerariae, decoct with water three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, decocting liquid is mixed stand-by; Get each 30Kg mixing of Rhizoma Imperatae and Oletum Trogopterori, decoct with water secondary, 3 hours for the first time, 1.5 hours for the second time, mix the secondary decocting liquid; Get the 40Kg Fructus Crataegi and decoct with water secondary, each 40 minutes; Merge above-mentioned three kinds of decocting liquids, filter, filtrate is concentrated into the thick paste of relative density 1.30～1.35 (80 ℃); 2Kg Pulvis Cornus Bubali Concentratus, 30Kg Pollen Typhae and 2Kg Radix Notoginseng fine powder are joined respectively in the above-mentioned thick paste, mixing, drying is pulverized, and makes capsule in incapsulating.
Claims (5)
1, a kind of medicine for the treatment of chronic hepatitis B is the medicament of being made by following materials based on weight:
The Radix Astragali 30～50 Pollen Typhaes 15～30
Oletum Trogopterori 15～30 Radix Notoginseng 1～5
Rhizoma Imperatae 15～30 Pulvis Cornus Bubali Concentratuss 1～5
Radix Puerariae 30～50 Fructus Crataegis 30～50.
2, the medicine of treatment chronic hepatitis B according to claim 1 is characterized in that described medicament is the dosage form on any pharmaceutics.
3, the medicine of treatment chronic hepatitis B according to claim 2 is characterized in that described medicament is a capsule.
4, the preparation method of the described treatment chronic hepatitis B of claim 3 medicine may further comprise the steps:
Getting Radix Notoginseng powder, to be broken into fine powder standby;
The Radix Astragali is decocted with water with Radix Puerariae, and Rhizoma Imperatae decocts with water with Oletum Trogopterori, and Fructus Crataegi decocts with water alone, obtains three kinds of decocting liquids respectively;
Merge above-mentioned three kinds of decocting liquids, filter, filtrate is concentrated into the thick paste of 80 ℃ of following relative densities 1.30～1.35;
Pulvis Cornus Bubali Concentratus, Pollen Typhae and Radix Notoginseng fine powder are joined in the above-mentioned thick paste, mixing, drying is pulverized, and makes capsule in incapsulating.
5, the preparation method of treatment chronic hepatitis B medicine according to claim 4 is characterized in that the Radix Astragali and Radix Puerariae are decocted with water three times, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time; Rhizoma Imperatae and Oletum Trogopterori are decocted with water secondary, 3 hours for the first time, 1.5 hours for the second time; Fructus Crataegi is decocted with water secondary, each 40 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100123740A CN1840106A (en) | 2006-01-23 | 2006-01-23 | Medicine for treating chronic hepatitis B and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006100123740A CN1840106A (en) | 2006-01-23 | 2006-01-23 | Medicine for treating chronic hepatitis B and its preparation method |
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| CN1840106A true CN1840106A (en) | 2006-10-04 |
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| CNA2006100123740A Pending CN1840106A (en) | 2006-01-23 | 2006-01-23 | Medicine for treating chronic hepatitis B and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435849A (en) * | 2014-12-16 | 2015-03-25 | 天圣制药集团股份有限公司 | Traditional Chinese medicine composition for treating chronic hepatitis |
| CN105106848A (en) * | 2015-09-14 | 2015-12-02 | 华燕美 | Traditional Chinese medicine composition for preventing and treating hepatitis B |
-
2006
- 2006-01-23 CN CNA2006100123740A patent/CN1840106A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104435849A (en) * | 2014-12-16 | 2015-03-25 | 天圣制药集团股份有限公司 | Traditional Chinese medicine composition for treating chronic hepatitis |
| CN105106848A (en) * | 2015-09-14 | 2015-12-02 | 华燕美 | Traditional Chinese medicine composition for preventing and treating hepatitis B |
| CN105106848B (en) * | 2015-09-14 | 2018-09-14 | 华燕美 | A kind of Chinese medicine composition for preventing hepatitis B |
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