CN1824652A - Production technology for extracting natural astaxanthin using super critical liquid carbon dioxide - Google Patents
Production technology for extracting natural astaxanthin using super critical liquid carbon dioxide Download PDFInfo
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- CN1824652A CN1824652A CNA2005100532945A CN200510053294A CN1824652A CN 1824652 A CN1824652 A CN 1824652A CN A2005100532945 A CNA2005100532945 A CN A2005100532945A CN 200510053294 A CN200510053294 A CN 200510053294A CN 1824652 A CN1824652 A CN 1824652A
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- astaxanthin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
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- Extraction Or Liquid Replacement (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a production process for extracting natural astaxanthin by utilizing supercritical fluid CO2. It is characterized by that it utilizes natural plant adonis chrysocyathus, places it in a supercritical fluid extraction equipment and adopts the processes of heating, boosting and injecting CO2 fluid so as to obtain natural astaxanthin.
Description
Technical field
The present invention relates to the production technique of plant pigments, the definite supercutical fluid CO that says so
2The production technique of natural astaxanthin is proposed.
Background technology
The method that tradition is extracted natural astaxanthin mostly adopts means such as physical pulverization, chemical solvents extraction, distillation method, drawback such as cause that product content is low, the residual height of chemical solvents, yield are low, poor stability, biological value are low.In addition, produce the astaxanthin except that part country in west adopts chemical synthesis, the main biogenetic derivation of astaxanthin is in aquatic animal, marine microalgae and biological fermentation.The ubiquity content astaxanthin is low, cost is high, extract shortcomings such as difficulty is big, molecular configuration difference and these are originated, and causes the product of natural astaxanthin not satisfy demand.
Summary of the invention
Purpose of the present invention is that a kind of supercutical fluid CO is provided
2Extract the production technique of natural astaxanthin, it mainly extracts astaxanthin from the natural phant Herba Adonidis, and the easy establishing in large scale of this plant is plucked, the content astaxanthin height, and the proposition cost is low, technology is simple, and security is good, natural environmental-protective.
For reaching above-mentioned technical purpose, the present invention has taked following technical scheme: supercutical fluid CO
2Extract the production technique of natural astaxanthin, it is characterized in that: the one, with the Herba Adonidis of full-bloom stage behind artificial or mechanical picking, carry out handling less than 50 ℃ low temperature dewatering, be crushed between the 20-80 order through the plant tissue pulverizer again, making diameter is the 2-5 millimeter, length is the cylindrical particle less than 10 millimeters, is stored in the hermetically sealed package of black or dead color, is stored in dark cryogenic local back up.Then, in the extraction solid material basket in the above-mentioned Herba Adonidis particulate material adding supercritical fluid extraction equipment, be positioned in the extraction kettle of supercritical fluid extraction equipment, with supercutical fluid CO
2Be spe medium, its controlled variable is
| Project | Extraction kettle | Separator 1# | Separator 2# |
| Working pressure (mpa) | 15-40 | 6-15 | 6-15 |
| Service temperature ℃ | ＜50 | ＜45 | ＜45 |
Cycling extraction 2-6 hour, the extraction yield of astaxanthin reached more than 90%.The principal goods of separator 1# and 2# is collected in respectively in the airtight package, vacuumizes, fill the nitrogen low tempertaure storage.Sample adopts high performance liquid chromatography to measure, and the content of its astaxanthin is between 60-300 gram/kilogram.The 2nd, adopt the continuous or intermittent type extraction of industrial 6# solvent oil, filter and obtain clarifying scarlet saturated solution, temperature control carries out reduction vaporization less than 45 ℃ in vaporizer, obtains the primary extract that enriched material is an astaxanthin ester.Detect through high performance liquid chromatography, the content of astaxanthin is at 50-120 gram/kilogram, and dissolvent residual is more than 25ppm.Then, in the extraction kettle in a certain amount of primary extract adding supercritical fluid extraction equipment, with CO
2Be spe medium, carry out the primary extract of supercritical fluid extraction refining astaxanthin ester, its parameter is
| Project | Extraction kettle | Separator 1# | Separator 2# |
| Working pressure (mpa) | 12-25 | 6-10 | 6-10 |
| Service temperature ℃ | ＜50 | ＜45 | ＜45 |
Cycling extraction 2-6 hour, the refined products in the extraction kettle is collected in respectively in the airtight package, vacuumize, fill the nitrogen low tempertaure storage, the sample thief high-performance liquid chromatogram determination, the content of its astaxanthin is between 60-300 gram/kilogram, solvent residual amount is less than 25ppm, until not detecting.The yield of astaxanthin ester reaches more than 90%.
Related starting material Herba Adonidis in above-mentioned technology, section belongs to Ranunculaceae, Adonis, another name spring adonis amurensis, annual herb, the high 10-30cm of plant, stem is upright, and blade is many, 3 times pinnation, lobule drapes over one's shoulders the pin type.Hua Dan gives birth to masthead footpath 3-5cm, single-lobe bright red, florescence 3-4 day.In China the north and ground such as siberian, Korea, Japan wild, but astaxanthin is rich in also life plantation.Especially the content astaxanthin of full-bloom stage horn of plenty more.
Owing to take technique scheme, the present invention compares with conventional art, and it is abundant to have a raw material, the content astaxanthin height, and extraction cost is low, and technology simply waits technical characterstic.
Embodiment
The present invention is further described below in conjunction with embodiment
Embodiment 1
Get Herba Adonidis dried particles 2Kg, pack in the supercritical flow body device solid phase extraction material basket, place in the extraction kettle of 5 liters of volumes, heating is warming up to 50 ℃, feeds CO
2Fluid, flow control is at 30L/h.Boost to 35mpa, the working pressure of control separating still 1# and 2# is respectively 8mpa and 6mpa, and temperature is respectively 45 ℃ and 40 ℃, circulates after 4 hours, emits scarlet paste material 78g from separating still 1#, detects, and the content of astaxanthin is 132g/kg.
Embodiment 2
Get Herba Adonidis extract 200g (content is 112g/kg) and pack in 1 liter of extraction kettle of supercritical flow body device, heating is warming up to 50 ℃, feeds CO
2Fluid, flow control boosts to 30mpa to 30L/h, the working pressure of control separating still 1# and 2# is respectively 8mpa and 6mpa, and temperature is respectively 45 ℃ and 40 ℃, circulates after 4 hours, emit scarlet paste material 102g from extraction kettle, after testing, content astaxanthin is 193.7g/kg.
Claims (2)
1, supercutical fluid CO
2Extract the production technique of natural astaxanthin, it is characterized in that: get the full-bloom stage Herba Adonidis, carry out handling less than 50 ℃ low temperature dewatering, be crushed to 20 orders-80 order through pulverizer, making diameter is the 2-5 millimeter, length is the cylindrical particle less than 10 millimeters, places black or dark-coloured hermetically sealed package, is stored in dark low temperature place; In the extraction solid material basket in the described Herba Adonidis particle adding supercritical fluid extraction equipment, be positioned in the extraction kettle of supercritical fluid extraction equipment, with fluid CO
2Be spe medium, controlled variable is:
Project Extraction kettle Separator 1# Separator 2#
Working pressure (mpa) 15-40 6-15 6-15
Service temperature ℃ ＜50 ＜45 ＜45
Cycling extraction 2-6 hour, the extraction yield of astaxanthin reached more than 90%.
2, supercutical fluid CO
2Extract the production technique of natural astaxanthin, it is characterized in that: adopt industrial 6# solvent oil temperature control in the extractor of stainless steel to carry out continuously or the intermittent type extraction less than 50 ℃, filtration obtains clarifying scarlet saturated solution, temperature control carries out reduction vaporization less than 45 ℃ in vaporizer, the enriched material that obtains is the primary extract of astaxanthin ester, primary extract is added in the extraction kettle of supercritical fluid extraction equipment, then with CO
2Be spe medium, controlled variable is:
Project Extraction kettle Separator 1# Separator 2#
Working pressure (mpa) 12-25 6-10 6-10
Service temperature ℃ ＜50 ＜45 ＜45
Cycling extraction 2-6 hour, its content astaxanthin was at 60-300g/kg, and the yield of astaxanthin ester reaches more than 90%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100532945A CN1824652A (en) | 2005-02-25 | 2005-02-25 | Production technology for extracting natural astaxanthin using super critical liquid carbon dioxide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100532945A CN1824652A (en) | 2005-02-25 | 2005-02-25 | Production technology for extracting natural astaxanthin using super critical liquid carbon dioxide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1824652A true CN1824652A (en) | 2006-08-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005100532945A Pending CN1824652A (en) | 2005-02-25 | 2005-02-25 | Production technology for extracting natural astaxanthin using super critical liquid carbon dioxide |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2085381A1 (en) | 2008-01-30 | 2009-08-05 | Bioptik Technology, Inc. | Method for obtaining natural astaxanthin from eggs and gonads of snails |
-
2005
- 2005-02-25 CN CNA2005100532945A patent/CN1824652A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2085381A1 (en) | 2008-01-30 | 2009-08-05 | Bioptik Technology, Inc. | Method for obtaining natural astaxanthin from eggs and gonads of snails |
| US8030523B2 (en) | 2008-01-30 | 2011-10-04 | Bioptik Technology, Inc. | Method for obtaining natural astaxanthin from eggs and gonads of snails |
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