CN1824128A - Semen locking medicinal preparation and its new preparation method - Google Patents
Semen locking medicinal preparation and its new preparation method Download PDFInfo
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- CN1824128A CN1824128A CNA2006100007487A CN200610000748A CN1824128A CN 1824128 A CN1824128 A CN 1824128A CN A2006100007487 A CNA2006100007487 A CN A2006100007487A CN 200610000748 A CN200610000748 A CN 200610000748A CN 1824128 A CN1824128 A CN 1824128A
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating prospermia, emission, night sweating, insomnia, dreamful sleep, sore and limp of loin and knee, etc, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of premature ejacuation emission that is used for, spontaneous sweating, insomnia and dreamful sleep, soreness of the waist and knees, the prescription and the preparation technology thereof of the thin and weak grade of limbs.
Background technology:
Premature ejacuation emission, spontaneous sweating, insomnia and dreamful sleep, soreness of the waist and knees, the thin and weak grade of limbs is clinically to see that symptom, the traditional Chinese medical science often take to take a tonic or nourishing food to build up one's health heart spleen more, the means of supplementing the kidney to control the nocturnal are treated it, and evident in efficacy.Locking smart ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, its pill that makes can be used for curing mainly premature ejacuation emission, spontaneous sweating, insomnia and dreamful sleep, soreness of the waist and knees, limbs are thin and weak etc.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
31～163 parts of 47～245 portions of Cortex Cinnamomis of 31～163 parts of Radixs Astragali of Radix Ginseng (processed with honey)
47～245 parts of 47～245 portions of Rhizoma Dioscoreaes of 94～490 parts of Fructus Corni of Radix Rehmanniae (wine is processed)
62～326 parts of Rhizoma Alismatis 31～163 portions of Concha Ostreaes of 31～163 parts of Cortex Moutans (forging)
31～163 parts of 62～326 parts of Semen Ziziphi Spinosaes of 31～163 parts of Os Draconis of Semen Platycladi (forging) (stir-fry)
31～163 parts of 31～163 parts of Fructus Schisandrae Chinensis of 31～163 parts of Radix Polygalaes of Poria cum Radix Pini (Radix Glycyrrhizae is processed) (processed with vinegar) are preferred:
120 parts of 180 portions of Cortex Cinnamomis of 120 parts of Radixs Astragali of Radix Ginseng (processed with honey)
180 parts of 180 portions of Rhizoma Dioscoreaes of 360 parts of Fructus Corni of Radix Rehmanniae (wine is processed)
240 parts of Rhizoma Alismatis 120 portions of Concha Ostreaes of 120 parts of Cortex Moutans (forging)
120 parts of 240 parts of Semen Ziziphi Spinosaes of 120 parts of Os Draconis of Semen Platycladi (forging) (stir-fry)
120 parts of 120 parts of Fructus Schisandrae Chinensis of 120 parts of Radix Polygalaes of Poria cum Radix Pini (Radix Glycyrrhizae is processed) (processed with vinegar)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, soft extract, fluid extract and extractum.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Cortex Cinnamomi, Fructus Schisandrae Chinensis two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Cortex Cinnamomi, schisandra chinensis medicinal material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the influence of testosterone concentration in the rat serum
Get body weight and be 35 of the SD male rats of 220～240g, be divided into 5 groups by body weight, 7 every group.Wherein 1,2 group is the person that do not excise the testis, 3～4 groups of excision testis (castration).Before the experiment with pentobarbital sodium 30mg/kg intraperitoneal injection of anesthesia, excision both sides testis, postoperative 8d, 1. and 2. 2～3 groups begin to gavage the extractum group respectively; 4 groups gavage methyl testosterone 1mg/kg; 1 group and 5 groups gavages distilled water in contrast.1 time/d of administration, 14d continuously.15d extract respectively rat one branch hole ball blood sampling, centrifugal, get serum and make the radioimmunoassay testosterone concentration, the results are shown in Table 1.
The influence of testosterone concentration in the table 1 pair rat serum (n=7, x ± s)
| Group | Dosage (g/kg) | Plasma testosterone (C/ngdl -1) |
| 1 normal distilled water group 2 technologies are 2. extractum group 4 methyl testosterone groups 5 castration distilled water groups of extractum group 3 technologies 1. | - 0.11 0.17 10ml/kg - | 20.6±6.1 47.6±13.2 * 5.6±4.1 ** 14.2±4.1 *** 4.4±3.2 |
Annotate:
*With 1 group than P＜0.01,
*With 5 groups than P＞0.05,
* *With 5 groups than P＜0.05
By table 1 as seen, technology 2. in the extractum group blood testosterone and castration distilled water matched group relatively, content does not increase; And technology 1. extractum group and castration distilled water matched group ratio not, testosterone concentration obviously increases (P＜0.01) in the blood; The Testosterone group of castration is compared with castration distilled water group, and the testosterone increase is remarkable (P＜0.05) also.
2, the influence that the mice endurance is tested
Get body weight and be 50 of the Male Kunming strain mice of 10～14g, be divided into 5 groups at random by body weight, 10 every group.Experimental technique is the same.Every mouse tail is born a heavy burden 10%, put into constant temperature (28～30 ℃) tank, do the experiment of swimming endurance, record drops in the water from mice and begins to avale the required time of the water surface to nose, for the mice endurance time, the results are shown in Table 2.Put to death then and get its seminal fluid capsule and place torsion balance to weigh, and do the t test, the results are shown in Table 3.
The influence of table 2 pair mice endurance experiment (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Swimming time T/min |
| 1 normal distilled water group 2 technologies are 2. extractum group 4 methyl testosterone groups 5 castration distilled water groups of extractum group 3 technologies 1. | 10 10 10 10 10 | - 0.22 0.34 10ml/kg - | 135.2±18.7 152.4±34.1 * 132.6±7.5 ** 119.2±31.3 *** 111.8±24.5 |
Annotate:
*With 1 group than P＜0.01,
*With 5 groups than P＞0.05,
* *With 5 groups than P＜0.05 as seen by table 2, the technology of giving medicine 1., 2. extractum group mice swimming time all obviously prolongs (P＜0.01) than castration distilled water group, technology 1. extractum group also prolongs (P＜0.05) than castration distilled water group not, is respectively to organize the elder of swimming time.Illustrate that medicine has resisting fatigue and the effect that improves the body tolerance.
The influence of table 3 pair mice seminal fluid capsule weight (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Seminal fluid capsule weight m/mg | |
| Gross weight | Every its weight of g body weight | |||
| 1 normal distilled water group 2 technologies are 2. extractum group 4 methyl testosterone groups 5 castration distilled water groups of extractum group 3 technologies 1. | 10 10 10 10 10 | - 0.22 0.34 10ml/kg - | 21.8±3.2 26.3±3.8 14.4±4.2 15.8±3.2 6.9±2.3 | 0.80±0.23 0.98±0.21 * 0.68±0.27 ** 0.56±0.24 *** 0.25±0.06 |
Annotate:
*With 1 group than P＜0.01,
*With 5 groups than P＞0.05,
* *With 5 groups than P＜0.05
3 as seen by, the mice of extractum group and methyl testosterone group, seminal fluid capsule weight ratio castration distilled water group obviously increases (P＜0.01); Technology 1. extractum group is compared with the normal distilled water group of castration not, and its weight difference is (P＜0.05) obviously.Illustrate that medicine and Testosterone are similar, have the effect of certain androgenic,
3, to the influence of rabbit sexual behaviour
Get body weight and be 20 of the adult large ear rabbits of 2.3～2.7kg, be divided into 2 groups, every group 10, adopt gastric infusion, wherein one group is the extractum group, and another group compares for the same capability distilled water, 1 time/d of administration, continuous 15d, 16d is with adult male rabbit and adult doe mate the number of times that the adult male rabbit sexual behaviour occurs in the observation 20min one by one.
The result shows, the male rabbit of extractum group is than the adult male rabbit of distilled water group, the sexual behaviour number of times (x ± s) from matched group (2.7 ± 3.2) inferior/20min increases to (9.5 ± 6.4) inferior/20min (P＜0.01), illustrate that medicine can obviously strengthen the sexual function of rabbit.
4, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment premature ejacuation emissions, spontaneous sweating, insomnia and dreamful sleep, soreness of the waist and knees, the medicine of the thin and weak grade of limbs, and change preparation technology can obviously strengthen its tonic heart spleen, clinical efficacies such as supplementing the kidney to control the nocturnal, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
The Radix Ginseng 31g Radix Astragali (processed with honey) 47g Cortex Cinnamomi 31g
Radix Rehmanniae 94g Fructus Corni (wine is processed) 47g Rhizoma Dioscoreae 47g
Rhizoma Alismatis 31g Cortex Moutan 31g Concha Ostreae (forging) 62g
Semen Platycladi 31g Os Draconis (forging) 62g Semen Ziziphi Spinosaes (stir-fry) 31g
Poria cum Radix Pini 31g Radix Polygalae (Radix Glycyrrhizae is processed) 31g flavor (processed with vinegar) 31g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Cortex Cinnamomi, Fructus Schisandrae Chinensis two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 2 times, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
The Radix Ginseng 163g Radix Astragali (processed with honey) 245g Cortex Cinnamomi 163g
Radix Rehmanniae 490g Fructus Corni (wine is processed) 245g Rhizoma Dioscoreae 245g
Rhizoma Alismatis 163g Cortex Moutan 163g Concha Ostreae (forging) 326g
Semen Platycladi 163g Os Draconis (forging) 326g Semen Ziziphi Spinosaes (stir-fry) 163g
Poria cum Radix Pini 163g Radix Polygalae (Radix Glycyrrhizae is processed) 163g Fructus Schisandrae Chinensis (processed with vinegar) 163g
PEG400 570g
Make 1000
Preparation method:
(1) gets Cortex Cinnamomi, Fructus Schisandrae Chinensis two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 2 times, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
The Radix Ginseng 120g Radix Astragali (processed with honey) 180g Cortex Cinnamomi 120g
Radix Rehmanniae 360g Fructus Corni (wine is processed) 180g Rhizoma Dioscoreae 180g
Rhizoma Alismatis 120g Cortex Moutan 120g Concha Ostreae (forging) 240g
Semen Platycladi 120g Os Draconis (forging) 240g Semen Ziziphi Spinosaes (stir-fry) 120g
Poria cum Radix Pini 120g Radix Polygalae (Radix Glycyrrhizae is processed) 120g Fructus Schisandrae Chinensis (processed with vinegar) 120g
Make 1000g
Preparation method:
(1) get Cortex Cinnamomi, schisandra chinensis medicinal material is beaten powder and is used as medicine;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 2 times, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) above active component is merged, add aspartame 5.0g, dextrin 400.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
The Radix Ginseng 84g Radix Astragali (processed with honey) 126g Cortex Cinnamomi 84g
Radix Rehmanniae 252g Fructus Corni (wine is processed) 126g Rhizoma Dioscoreae 126g
Rhizoma Alismatis 84g Cortex Moutan 84g Concha Ostreae (forging) 168g
Semen Platycladi 84g Os Draconis (forging) 168g Semen Ziziphi Spinosaes (stir-fry) 84g
Poria cum Radix Pini 84g Radix Polygalae (Radix Glycyrrhizae is processed) 84g Fructus Schisandrae Chinensis (processed with vinegar) 84g
Make 1000
Preparation method:
(1) get Cortex Cinnamomi, schisandra chinensis medicinal material is beaten powder and is used as medicine;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 2 times, each 1.5 hours, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) above active component is merged, add aspartame 3.0g, mannitol 190.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
31～163 parts of 47～245 portions of Cortex Cinnamomis of 31～163 parts of Radixs Astragali of Radix Ginseng (processed with honey)
47～245 parts of 47～245 portions of Rhizoma Dioscoreaes of 94～490 parts of Fructus Corni of Radix Rehmanniae (wine is processed)
62～326 parts of Rhizoma Alismatis 31～163 portions of Concha Ostreaes of 31～163 parts of Cortex Moutans (forging)
31～163 parts of 62～326 parts of Semen Ziziphi Spinosaes of 31～163 parts of Os Draconis of Semen Platycladi (forging) (stir-fry)
31～163 parts of 31～163 parts of Fructus Schisandrae Chinensis of 31～163 parts of Radix Polygalaes of Poria cum Radix Pini (Radix Glycyrrhizae is processed) (processed with vinegar).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
120 parts of 180 portions of Cortex Cinnamomis of 120 parts of Radixs Astragali of Radix Ginseng (processed with honey)
180 parts of 180 portions of Rhizoma Dioscoreaes of 360 parts of Fructus Corni of Radix Rehmanniae (wine is processed)
240 parts of Rhizoma Alismatis 120 portions of Concha Ostreaes of 120 parts of Cortex Moutans (forging)
120 parts of 240 parts of Semen Ziziphi Spinosaes of 120 parts of Os Draconis of Semen Platycladi (forging) (stir-fry)
120 parts of 120 parts of Fructus Schisandrae Chinensis of 120 parts of Radix Polygalaes of Poria cum Radix Pini (Radix Glycyrrhizae is processed) (processed with vinegar).
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, soft extract, fluid extract and extractum.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds 1 suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) gets Cortex Cinnamomi, Fructus Schisandrae Chinensis two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Cortex Cinnamomi, schisandra chinensis medicinal material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) gets Cortex Cinnamomi, Fructus Schisandrae Chinensis two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate; Gained water extract filters, and is condensed into thick extractum, and is standby; Water extract device in addition stores, and leaves standstill, and filters, and filtrate concentrates, and is standby;
(2) get Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Concha Ostreae, Os Draconis, Poria cum Radix Pini's Six-element medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into thick paste; Be used as medicine with above gained active component mixing in stewedization of Colla cornus cervi back;
(3) get the residue medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Cortex Cinnamomi, schisandra chinensis medicinal material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100007487A CN1824128A (en) | 2006-01-12 | 2006-01-12 | Semen locking medicinal preparation and its new preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100007487A CN1824128A (en) | 2006-01-12 | 2006-01-12 | Semen locking medicinal preparation and its new preparation method |
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| CN1824128A true CN1824128A (en) | 2006-08-30 |
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| CNA2006100007487A Pending CN1824128A (en) | 2006-01-12 | 2006-01-12 | Semen locking medicinal preparation and its new preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7968128B2 (en) | 2008-11-03 | 2011-06-28 | Viva Pharmaceutical Inc. | Plant extract compositions for affecting sleep |
| CN105213796A (en) * | 2015-10-20 | 2016-01-06 | 张士远 | A kind of Chinese medicine preparation and method for making curing mainly night sweat |
| CN107348495A (en) * | 2017-06-20 | 2017-11-17 | 苏州市李良济健康产业有限公司 | A kind of preparation method for the health products for strengthening energy |
-
2006
- 2006-01-12 CN CNA2006100007487A patent/CN1824128A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7968128B2 (en) | 2008-11-03 | 2011-06-28 | Viva Pharmaceutical Inc. | Plant extract compositions for affecting sleep |
| CN105213796A (en) * | 2015-10-20 | 2016-01-06 | 张士远 | A kind of Chinese medicine preparation and method for making curing mainly night sweat |
| CN107348495A (en) * | 2017-06-20 | 2017-11-17 | 苏州市李良济健康产业有限公司 | A kind of preparation method for the health products for strengthening energy |
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