CN1807653A - Active donkey-hide gelatin collagen peptide product - Google Patents
Active donkey-hide gelatin collagen peptide product Download PDFInfo
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- CN1807653A CN1807653A CN 200510044311 CN200510044311A CN1807653A CN 1807653 A CN1807653 A CN 1807653A CN 200510044311 CN200510044311 CN 200510044311 CN 200510044311 A CN200510044311 A CN 200510044311A CN 1807653 A CN1807653 A CN 1807653A
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- donkey
- hide gelatin
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- peptide product
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Abstract
The invention discloses a donkey-hide gelatin producing method in tradition approach, which is characterized by the following: controlling hydrolysis level in enzyme internally method by specific recombination prolease; making the dissolvability and biological activity to improve; obtaining basic structure and nature of donkey-hide gelatin collagen with non-destructive small molecule donkey-hide gelatin collagen peptide.
Description
The present invention relates to a kind of manufacturing of active donkey-hide gelatin collagen peptide product, be biological engineering science and technology goods.
Donkey-hide gelatin is a kind of traditional nutrient excellent product of enriching blood, and the beginning is stated from Shennong's Herbal the earliest, classifies as top grade; Day: donkey-hide gelatin is gone into to deceive the donkey hide white silk with the water of A Jing and is become glue also; 60 li in northeast, Yanggu County, mansion, Yanzhou of A Jing go through a thousand li in the water volt row ground of this clear Ji and in this well; With glue just also suitable with blood vessels.According to Compendium of Material Medica: except that donkey hide, skins such as buffalo, pig, horse are also made fried donkey-hide gelatin usefulness, and be expensive with donkey hide later age then; The donkey-hide gelatin kind optimum made from the decocting of A Jing crow donkey hide is so a donkey-hide gelatin; LI Shi-Zhen is thought: the donkey-hide gelatin fluid infusion of can enriching blood, all available treatment of all diseases of all deficiency of Yin.Modern medicine proves that donkey-hide gelatin can improve the quantity of red corpuscle and oxyphorase, has the function that promotes hematopoiesis.
But, the donkey-hide gelatin product that traditional method produces, owing to be more macromolecular donkey-hide gelatin collagen goods, molecular weight is about about several ten thousand, is unfavorable for the abundant absorption and the utilization of human body, physiological function also is subjected to certain restriction; Patents (ZL99116437.7) such as Wuhan Lee is newly-built are pointed out: by " ... preferred enzymatic hydrolysis condition; high more according to free amino group in the protein component (amino nitrogen) content; the principle that protein molecule is more little, measure hydrolysis result with formaldehyde method, and definite optimization enzymatic hydrolysis condition." as seen, the optimization index of its liquid donkey-hide gelatin is to reach degree that complete hydrolysis becomes amino acid molecular as best order ground; But, like this will be because of destroying the basic structure of donkey-hide gelatin collagen peptide, and the essential property of donkey-hide gelatin collagen can not be guaranteed, thus influence its medical functions.
For this reason, the present invention is by specific compound protease, under the condition of gentleness with enzyme in cutting method, the non-collagen tail peptide moiety of tropocollagen molecule N and C end is cut, make it become solvability and physiologically active is all fully improved, and the small molecules donkey-hide gelatin collagen peptide that the basic structure of collagen and character are not damaged, its molecular weight is measured by capillary electrophoresis, the condition of control enzyme digestion reaction makes its molecular-weight average in 1000D～7000D scope, mainly be distributed in about 3000D～5000D, thereby make and both have better physiology biological activity, safe and reliable again donkey-hide gelatin collagen peptide product; If the degree of enzymolysis environment excessively serious or enzymolysis is of poor quality, making it be degraded to molecular-weight average is tens amino acid molecular or amino acid fragments to hundreds of, then can destroy the basic collagen structure and the character of donkey-hide gelatin collagen peptide, the physiology and the nourishing blood function of donkey-hide gelatin are affected, are unfavorable for keeping the essential property of donkey-hide gelatin.The donkey-hide gelatin collagen peptide product that makes with this law can improve the activity of donkey-hide gelatin collagen to greatest extent, and keeps the essential property of donkey-hide gelatin constant simultaneously.
Its manufacturing processed is as follows: get and be dissolved in after 100 parts of donkey-hide gelatin are pulverized in 150～300 parts in the warm pure water, be heated to 80～95 ℃ and keep carrying out in 5～20 minutes sterilization, fast cooling is cooled to 30～60 ℃, adjust pH value in 5～8 scopes, adding specific complex proteinase-10 .01～1 part, carry out controlled enzyme digestion reaction at constant temperature, measure the molecular weight of donkey-hide gelatin collagen peptide, the molecular-weight average that makes final product is in 1000D～7000D, mainly be distributed near 3000D～5000D, then this enzymolysis solution made finished product through spraying drying.
Production with reality is example below, further specifies the manufacturing processed of this product.After taking by weighing the pulverizing of 100kg donkey-hide gelatin, in stainless cylinder of steel, make it to be dissolved in 40～50 ℃ the 250kg pure water, heat temperature raising to 85 ℃ then, keep carrying out in 10～20 minutes sterilization, cooling is cooled to 45 ℃, adjusting pH value is about 6.0, add 30g specific complex proteolytic enzyme, enzymolysis under constant temperature is by measuring control, make the final product molecular-weight average in 1000D～7000D, mainly be distributed in about 3000D～5000D, then this enzymolysis solution carried out spraying drying, thereby make active donkey-hide gelatin collagen peptide product.
Claims (2)
1. active donkey-hide gelatin collagen peptide product innovation, be characterised in that donkey-hide gelatin is through the specific complex enzymic hydrolysis after, its molecular-weight average mainly is distributed near 3000D～5000D in 1000D～7000D.
2. the manufacture method of an active donkey-hide gelatin collagen peptide.Donkey-hide gelatin is pulverized the back in stainless cylinder of steel, be dissolved in water, concentration about 15～40%, be warming up to 80～95 ℃ of sterilizations 5～20 minutes, be cooled to 30～60 ℃ then, add specific complex proteinase-10 .01～1% and mix, PH is about about 6, the degree of control enzyme digestion reaction makes molecular-weight average in 1000D～7000D, mainly be distributed near 3000D～5000D, with this enzymolysis solution process spraying drying, make active donkey-hide gelatin collagen peptide product then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510044311 CN1807653A (en) | 2005-07-26 | 2005-07-26 | Active donkey-hide gelatin collagen peptide product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510044311 CN1807653A (en) | 2005-07-26 | 2005-07-26 | Active donkey-hide gelatin collagen peptide product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1807653A true CN1807653A (en) | 2006-07-26 |
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| CN 200510044311 Pending CN1807653A (en) | 2005-07-26 | 2005-07-26 | Active donkey-hide gelatin collagen peptide product |
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| CN (1) | CN1807653A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102101884A (en) * | 2009-12-18 | 2011-06-22 | 济南瑞安药业发展有限公司 | Preparation method and use of donkey-hide gelatin polypeptide |
| CN101285087B (en) * | 2008-04-30 | 2011-12-07 | 北京华达杰瑞生物技术有限公司 | Polypeptides with donkey hide gelatin and method for preparing same |
| WO2013097274A1 (en) | 2011-12-29 | 2013-07-04 | 山东东阿阿胶股份有限公司 | Active small-molecule donkey-hide gelatin mixture and preparation method and application thereof |
| CN104069044A (en) * | 2013-04-10 | 2014-10-01 | 山东东阿阿胶股份有限公司 | Small-molecular donkey-hide gelatin facial mask, as well as preparation method and application thereof |
| JP2016536344A (en) * | 2013-09-25 | 2016-11-24 | シャンドン ドンア アジャオ カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄｏｎｇ−Ｅ Ｅ−Ｊｉａｏ Ｃｏ．， Ｌｔｄ． | Application of glue or high value-added processed products of glue in the manufacture of hair modifier compositions |
| CN107674903A (en) * | 2017-11-02 | 2018-02-09 | 林峰 | Donkey-hide gelatin active peptide, composition and preparation method |
| CN108094815A (en) * | 2018-01-04 | 2018-06-01 | 中美御康生物科技（北京）有限公司 | It enriches blood collagen solid beverage |
-
2005
- 2005-07-26 CN CN 200510044311 patent/CN1807653A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101285087B (en) * | 2008-04-30 | 2011-12-07 | 北京华达杰瑞生物技术有限公司 | Polypeptides with donkey hide gelatin and method for preparing same |
| CN102101884A (en) * | 2009-12-18 | 2011-06-22 | 济南瑞安药业发展有限公司 | Preparation method and use of donkey-hide gelatin polypeptide |
| WO2013097274A1 (en) | 2011-12-29 | 2013-07-04 | 山东东阿阿胶股份有限公司 | Active small-molecule donkey-hide gelatin mixture and preparation method and application thereof |
| KR20140067145A (en) * | 2011-12-29 | 2014-06-03 | 산둥 동-이 이-지아오 컴퍼니 리미티드 | Active small-molecule donkey-hide gelatin mixture and preparation method and application thereof |
| JP2015501647A (en) * | 2011-12-29 | 2015-01-19 | シャンドン ドンア アジャオ カンパニー リミテッドＳｈａｎｄｏｎｇｄｏｎｇ−Ｅ Ｅ−Ｊｉａｏ Ｃｏ．， Ｌｔｄ． | Active small molecule glue mixture, preparation method and use thereof |
| EP2762012A4 (en) * | 2011-12-29 | 2015-06-03 | Shan Dong Dong E E Jiao Co Ltd | Active small-molecule donkey-hide gelatin mixture and preparation method and application thereof |
| KR101635186B1 (en) | 2011-12-29 | 2016-06-30 | 산둥 동-이 이-지아오 컴퍼니 리미티드 | Active small-molecule donkey-hide gelatin mixture and preparation method and application thereof |
| CN104069044A (en) * | 2013-04-10 | 2014-10-01 | 山东东阿阿胶股份有限公司 | Small-molecular donkey-hide gelatin facial mask, as well as preparation method and application thereof |
| JP2016536344A (en) * | 2013-09-25 | 2016-11-24 | シャンドン ドンア アジャオ カンパニー リミテッドＳｈａｎｄｏｎｇ Ｄｏｎｇ−Ｅ Ｅ−Ｊｉａｏ Ｃｏ．， Ｌｔｄ． | Application of glue or high value-added processed products of glue in the manufacture of hair modifier compositions |
| CN107674903A (en) * | 2017-11-02 | 2018-02-09 | 林峰 | Donkey-hide gelatin active peptide, composition and preparation method |
| CN108094815A (en) * | 2018-01-04 | 2018-06-01 | 中美御康生物科技（北京）有限公司 | It enriches blood collagen solid beverage |
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Application publication date: 20060726 |