CN1799642A - Method for preparing titanium-hydroxyapatite bioactive material - Google Patents
Method for preparing titanium-hydroxyapatite bioactive material Download PDFInfo
- Publication number
- CN1799642A CN1799642A CNA2005101009678A CN200510100967A CN1799642A CN 1799642 A CN1799642 A CN 1799642A CN A2005101009678 A CNA2005101009678 A CN A2005101009678A CN 200510100967 A CN200510100967 A CN 200510100967A CN 1799642 A CN1799642 A CN 1799642A
- Authority
- CN
- China
- Prior art keywords
- titanium
- constant temperature
- hydroxyapatite
- hours under
- physiological fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 19
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 15
- 230000000975 bioactive effect Effects 0.000 title claims description 11
- 238000000034 method Methods 0.000 title abstract description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 21
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 13
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000010936 titanium Substances 0.000 claims abstract description 13
- 229910052719 titanium Inorganic materials 0.000 claims abstract description 13
- 230000003203 everyday effect Effects 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 13
- 238000004088 simulation Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 230000004071 biological effect Effects 0.000 abstract description 5
- 239000011149 active material Substances 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 210000000988 bone and bone Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 229910003089 Ti–OH Inorganic materials 0.000 description 1
- 229910003077 Ti−O Inorganic materials 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001652 electrophoretic deposition Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 238000007750 plasma spraying Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009645 skeletal growth Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a method for preparing titanium- hydroxyapatite biological active material, comprising the following steps: putting the titanium slice into hydrogen dioxide solution for 0.5-2 hours under constant temperature of 60-80 Deg C; getting out the titanium slice and washing, then immersing in the NaOH solution for 24-28 hours under constant temperature of 60-80 Deg C; getting out and washing, keeping for 18-30 hours under constant temperature of 100 Deg C; finally immersing in the imitating physiological solution for 3-15 days; changing the imitating physiological solution every day. The invention overcomes the problem of not thermo-stable generally existed in current titanium- hydroxyapatite biological active material, the titanium surface can be effectively bio-activated by using this method, the product prepared in this invention can avoid damage to the material biological activity by high temperature treatment.
Description
Technical field
The present invention relates to Osteopathic Medicine material field, be specifically related to a kind of preparation method of titanium-hydroxyapatite bioactive material.
Background technology
Along with economic development and living standard improve, the demand of artificial tooth material and artificial bone is also increasing.The osteoarthrosis alternate material is an application prospect class biomedical material very widely.Hydroxyapatite is the main inorganic composition of tissues such as tooth and bone, has the good biological activity and the compatibility.But hydroxyapatite character is more crisp, should not be directly used in and be subjected to force environment; On the other hand, titanium and titanium alloy have good mechanical performance and corrosion resistance, but its biological activity is relatively poor, and application is restricted.Artificial material at metal surface phosphors coating lime stone chemical compound can possess good biological activity and good mechanical performance simultaneously, is a kind of application prospect material very widely.
Coating deposition method (comprising plasma spraying process, sol-gal process, electrophoretic deposition) commonly used at present all exists high temperature to cause the coating decomposition to peel off the problem that bond strength descends.
Summary of the invention
The objective of the invention is to overcome existing titanium-hydroxyapatite bioactive material ubiquity can not resistant to elevated temperatures problem, a kind of method for preparing titanium-hydroxyapatite bioactive material is provided, utilize this method to carry out bioactivation to the titanium surface effectively, made titanium-hydroxyapatite bioactive material can avoid high-temperature process that the biological activity of material is damaged.
To achieve these goals, the present invention adopts following technical scheme:
A kind of preparation method of titanium-hydroxyapatite bioactive material, form by following steps:
(1) the titanium sheet is joined in the hydrogen peroxide (mass concentration 30%), constant temperature is 0.5～2 hour under 60～80 ℃ of temperature, obtains containing the Detitanium-ore-type TiO of a large amount of Ti-OH on the titanium surface
2
(2) take out titanium sheet and cleaning, be immersed in then in the NaOH solution, constant temperature is 24～48 hours under 60～80 ℃ of temperature, generates the Na-Ti-O hydrogel layer chemical compound of biologically active;
(3) take out and clean, 100 ℃ of following constant temperature 18～30 hours, hydrogel layer changed fine and close amorphous state metatitanic acid sodium into;
(4) in the simulation physiological fluid, soaked 3～15 days at last; Keep changing every day the simulation physiological fluid.
Above-mentioned simulation physiological fluid is for containing following ion: Na
+K
+Mg
2+Ca
2+Cl
-HCO
3 -HPO
4 2-SO
4 2-, its concentration is respectively 142.0,5.0,1.5,2.5,147.8,4.2,1.0, and 0.5mmol/L, pH value are 7.3.
Compared with prior art, the present invention has following beneficial effect: (1) equipment and simple to operate; (2) coating that can all be had at complex-shaped material surface; (3) can assign to change the composition of coating by changing the one-tenth of simulating physiological fluid; (4) can make protein, skeletal growth factor, codeposition takes place in materials such as antibiotic in coating.
The specific embodiment
Embodiment 1
A titanium sheet (length and width thick for 10*10*1 millimeter) is immersed in the hydrogen peroxide of 30% (mass concentration) of 10ml, constant temperature is 1 hour under 60 ℃ temperature.Take out also and clean, the concentration that is immersed in 10ml then is in the NaOH solution of 5M, 60 ℃ of following constant temperature 24 hours, takes out also and cleans, 100 ℃ of following constant temperature 24 hours.Immersed at last in the 10ml simulation physiological fluid 7 days, and changed the simulation physiological fluid every day, can obtain titanium-hydroxyapatite bioactive material.
Embodiment 2
A titanium sheet (length and width thick for 10*10*1 millimeter) is immersed in the hydrogen peroxide of 30% (mass concentration) of 10ml, constant temperature is 1 hour under 70 ℃ temperature.Take out also and clean, the concentration that is immersed in 10ml then is in the NaOH solution of 5M, 70 ℃ of following constant temperature 24 hours, takes out also and cleans, 100 ℃ of following constant temperature 24 hours.Immersed at last in the 10ml simulation physiological fluid 5 days, and changed the simulation physiological fluid every day, can obtain titanium-hydroxyapatite bioactive material.
Embodiment 3
A titanium sheet (length and width thick for 10*10*1 millimeter) is immersed in the hydrogen peroxide of 30% (mass concentration) of 10ml, constant temperature is 1 hour under 80 ℃ temperature.Take out also and clean, the concentration that is immersed in 10ml then is in the NaOH solution of 5M, 80 ℃ of following constant temperature 24 hours, takes out also and cleans, 100 ℃ of following constant temperature 24 hours.Immersed at last in the 10ml simulation physiological fluid 3 days, and changed the simulation physiological fluid every day, can obtain titanium-hydroxyapatite bioactive material.
Claims (4)
1, a kind of preparation method of titanium-hydroxyapatite bioactive material is characterized in that being made up of following steps:
(1) the titanium sheet is joined in the hydrogen peroxide, constant temperature is 0.5～2 hour under 60～80 ℃ of temperature;
(2) take out titanium sheet and cleaning, be immersed in then in the NaOH solution, constant temperature is 24～48 hours under 60～80 ℃ of temperature;
(3) take out and clean, 100 ℃ of following constant temperature 18～30 hours;
(4) in the simulation physiological fluid, soaked 3～15 days at last, keep changing every day the simulation physiological fluid.
2, preparation method according to claim 1 is characterized in that the described simulation physiological fluid of step (4) is for containing following ion: Na
+K
+Mg
2+Ca
2+Cl
-HCO
3 -HPO
4 2-SO
4 2-, its concentration is respectively 142.0,5.0,1.5,2.5,147.8,4.2,1.0, and 0.5mmol/L, pH value are 7.3.
3, preparation method according to claim 1 is characterized in that the mass concentration of the described hydrogen peroxide of step (1) is 30%.
4, preparation method according to claim 1 is characterized in that the concentration of the described NaOH solution of step (2) is 5mol/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101009678A CN100369636C (en) | 2005-11-07 | 2005-11-07 | Method for preparing titanium-hydroxyapatite bioactive material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101009678A CN100369636C (en) | 2005-11-07 | 2005-11-07 | Method for preparing titanium-hydroxyapatite bioactive material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1799642A true CN1799642A (en) | 2006-07-12 |
| CN100369636C CN100369636C (en) | 2008-02-20 |
Family
ID=36810000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005101009678A Expired - Fee Related CN100369636C (en) | 2005-11-07 | 2005-11-07 | Method for preparing titanium-hydroxyapatite bioactive material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100369636C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100927A (en) * | 2011-01-22 | 2011-06-22 | 浙江理工大学 | Porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and preparation method thereof |
| CN107899070A (en) * | 2017-11-13 | 2018-04-13 | 西南大学 | A kind of artificial bone and preparation method of imitative cancellous bone structure and ultralow elasticity modulus |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50212422D1 (en) * | 2001-06-06 | 2008-08-14 | Biomet Merck Gmbh | Apatite-coated metallic material, process for its production and use |
| CN1546178A (en) * | 2003-12-17 | 2004-11-17 | 西北有色金属研究院 | Technique for coating porous titanium surface with hydroxyapatite layer |
| CN1233424C (en) * | 2004-01-16 | 2005-12-28 | 东南大学 | Bionic preparing method for depositing calcium and phosphor active layer on memory alloy of nickel and titanium for medical use |
-
2005
- 2005-11-07 CN CNB2005101009678A patent/CN100369636C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100927A (en) * | 2011-01-22 | 2011-06-22 | 浙江理工大学 | Porous hydroxy calcium phosphate nanometer particle-modified titanium-based titanate nanowire biologic support material and preparation method thereof |
| CN107899070A (en) * | 2017-11-13 | 2018-04-13 | 西南大学 | A kind of artificial bone and preparation method of imitative cancellous bone structure and ultralow elasticity modulus |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100369636C (en) | 2008-02-20 |
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