CN1775289B - Multi vitamin oral disintegrating tablet formulation and its preparing method - Google Patents
Multi vitamin oral disintegrating tablet formulation and its preparing method Download PDFInfo
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- CN1775289B CN1775289B CN 200410092804 CN200410092804A CN1775289B CN 1775289 B CN1775289 B CN 1775289B CN 200410092804 CN200410092804 CN 200410092804 CN 200410092804 A CN200410092804 A CN 200410092804A CN 1775289 B CN1775289 B CN 1775289B
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- 235000012730 carminic acid Nutrition 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000021209 fruit soup Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960004391 lorazepam Drugs 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229960003642 nicergoline Drugs 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 1
- 229960004535 oxazepam Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical compound OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 description 1
- 229960001553 phloroglucinol Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Abstract
The present invention provides a multivitamin oral disintegrant tablet prescription and its preparation method. Said prescription composition includes combination of several vitamins as main medicinal component (called functional component for health-care food), filling agent, disintegrant, corrective and lubricant. Said oral disintegrant tablet can effectively supplement several vitamins necessary for human body.
Description
Technical field
The present invention relates to multivitamin and multiple suitable pharmaceutical necessities or food additive are formed in the oral cavity oral cavity disintegration tablet of disintegrate and the preparation method of this tablet rapidly.
Background technology
Can be used for oral multivitamin quasi drugs or health food at present, forms such as Film coated tablets, chewable tablet, film, soft capsule, hard capsule, oral liquid, drop are arranged usually.Because solid preparations such as tablet or capsule need use water swallow, so for old man, baby or the patient of dysphagia is arranged, more be ready use or only can use liquid preparations such as oral liquid, drop.In general, the vitamins great majority are stable inadequately in solution, decompose easily and go bad, and brought sizable difficulty for liquid preparation technology, also are unfavorable for its steady in a long-term preservation simultaneously.Therefore the exploitation rapid disintegrate of energy and easy-to-swallow vitamins oral cavity disintegration tablet in the oral cavity has market prospect preferably.And the disintegrate rapidly under saliva effect of this tablet is except being applicable to old man, baby or the patient of dysphagia being arranged, the also favor of being taken an excursion in an open country probably and temporarily can't obtain the personage of drinking-water during the journey.
The oral cavity quickly disintegrating tablet of listing adopts three kinds of patented technologies, the i.e. mechanography (Flashdose method) of the direct compression process (Orasolv method) of the freeze-drying of R.P Scherer company (Zydis method), Cima company, Takeda company usually at present.
Its preparation technology is more, and is existing with regard to the simply introduction of several important technologies works one.
Freeze drying process: utilizing freeze drying process to prepare oral cavity quick disintegrating slice has been a very mature technique abroad, the patented technology such as the USP2166074 of many relevant this respects is arranged, 3234091,4371516; 4946684,4302502 grades and product such as Expidet, Lyoc, Rapidis, Wafer.Zydis etc.The oral rapidly disintegrating formulation that oxazepam, phloroglucinol, nicergoline, lorazepam etc. are arranged that has gone on the market and be about to go on the market.Its main preparation technology is as follows: ((＜60mg=comprises that with water-soluble base the suspension of polysaccharide, gelatin, polypeptide etc. and some other adjuvants such as suspensoid, wetting agent, coloring agent etc. quantitatively is sub-packed in the fixed mold for＜400mg=or water soluble drug with insoluble drugs, be frozen into solid-state, decompression heats up again, remove moisture by sublimation, obtain the solid preparation of high porosity.With fast disintegrating tablet disintegrate rapidly in the oral cavity that freeze-drying makes, good mouthfeel, the product of gained are open mesh skeleton structure, intensity is not high, and is frangible, the integrity of the tablet that is hard to keep, easily phenomenon taking place back to melt, makes the whole operation failure in freezing dry process.
Solid solution technology: in order to overcome some shortcomings that Freeze Drying Technique prepares fast disintegrating tablet, the mixture of usefulness gelatin, pectin, soybean fiber etc. such as Gole and contain the aminoacid of 2～twelve carbon atom such as glycine etc. as framework material, add medicine, antioxidant, antiseptic and correctives etc. and be dissolved in first solvent, then temperature is reduced the solidification temperature that is equal to or less than first solvent, such first solvent just exists with solid-state.At this moment, add second solvent, this solvent and first solvent can dissolve each other, but can not dissolve each other with framework material, and then first solvent is cemented out from skeleton by second solvent, vapor away the second remaining solvent then, obtain the medicine skeleton.Can also add better and the 3rd solvent that mix with second solvent of volatility again if the volatility of second solvent is bad, second solvent is fallen in displacement, vapors away the 3rd remaining solvent again.The mixture of framework material and medicine etc. can exist with various states such as solution, suspension, dispersion liquid, emulsions in first solvent, and the product that obtains can disintegrate in several seconds, and intensity is greater than lyophilisation product.The method choice of Solvent is very important, at first first solvent will dissolve each other with second solvent, but the mixture of skeleton agent etc. must be dissolved in first solvent and be insoluble to second solvent, and secondly the fusing point of second solvent will be lower than first solvent, and volatility is greater than first solvent.
Drying process with atomizing: adopt drying process with atomizing to prepare fast disintegrating tablet and mainly comprise following 4 steps: (1) preparation porous particles is as the support skeleton of tablet; (2) add medicine and other adjuvants; (3) film-making; (4) tablet coating.Wherein most critical is the first step.Support the composition of skeleton to comprise the polymer (main component) that contains electrostatic charge, solubilizing agent and the extender that in solution, has together main polymer identical charges.The dissolubility of solubilizing agent in water is greater than main polymer, supports the dissolubility of skeleton in aqueous solution to improve.To support framework ingredient and volatile material such as ethanol etc. and buffer agent to adopt spray drying technology to make porous particles, add medicine and suitable adjuvant such as binding agent, filler, correctives, aromatic etc. then, with film-makings such as common pressed-disc technique such as direct compressions, the tablet that makes wraps thin film polyvinylpyrrolidone or polyvinyl alcohol clothing again to improve its integrity.After spray dried products ran into saliva, because the tablet porosity is big, moisture can enter tablet inside rapidly, makes the rapid disintegrate of tablet owing to existing electrostatic charge to repel mutually between the material.
Direct compression technology: though several technologies in front can make high-quality oral cavity quick disintegrating slice, technology is all comparatively complicated, and cost is also higher, therefore adopts common pressed-disc technique to prepare the hot issue that oral cavity quick disintegrating slice becomes people's research in recent years.Someone utilizes disintegrating agent with good disintegrating property such as cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, crosslinked carboxymethylstach sodium, low-substituted hydroxypropyl cellulose, processing agar etc., prepares oral cavity quick disintegrating slice with direct compression process.
Summary of the invention
The present invention relates to a kind of multi vitamin oral disintegrating tablet, it is characterized in that: its composition is by weight percentage:
Multivitamin combination 5～30%;
Filler 20～60%, filler are the combination of microcrystalline Cellulose, lactose and mannitol, the combination of the combination of microcrystalline Cellulose, lactose, xylitol and dextrin or microcrystalline Cellulose, lactose, mannitol and dextrin;
Disintegrating agent 10～40%, disintegrating agent are the combination of crospolyvinylpyrrolidone or crospolyvinylpyrrolidone and low-substituted hydroxypropyl methylcellulose;
Effervescent 0～32%, the effervescent acid-base pair that to be citric acid, tartaric acid or malic acid form with sodium bicarbonate or sodium carbonate;
Correctives 1～10%, correctives are mannitol, essence and A Siba one or more the combination in sweet;
Binding agent 0.4～10%, binding agent are one or more the combination in hydroxypropyl emthylcellulose, polyvinylpyrrolidone, pregelatinized Starch, polyacrylic resin, arabic gum and the pectin;
Lubricant 0.05～5%, lubricant are a kind of in magnesium stearate, polyethylene glycol 6000, Pulvis Talci, Stepanol MG and the micropowder silica gel; More than various composition sums be 100%.
Further, the present invention relates to a kind of multi vitamin oral disintegrating tablet, it is characterized in that: vitamin B1, B2, B6 content are at 0.1mg～10mg, vitamin B12 content is at 0.1 μ g～10 μ g, folate content is at 10 μ g～500 μ g, niacinamide content is at 1.0mg～20mg, calcium pantothenate content is at 1.0mg～20mg, Vitamin C content is at 10mg～120mg, vitamin A content is in 1000～5000 ius, vitamin D content is in 100～1000 ius, and content of vitamin E is in 1～100 iu.
The present invention adopts common pressed-disc technique to prepare the multivitamin oral cavity disintegration tablet first, for example wet granule compression tablet technology or direct compression technology, do not need special producing condition, equipment, simplify the preparation technology of oral cavity disintegration tablet, overcome complex process in the conventional art, defective that production cost is high, helped the industrialization of multivitamin oral cavity disintegration tablet.
Though vitamins has its unique abnormal smells from the patient, but and nonirritant, there is not too unpleasant taste yet, be slightly tart flavour, astringent taste etc. of mouthfeel, therefore select correctives, its technical difficulty is very not big, can adjust kind, the consumption of correctives according to the taste of different crowd, can reach requirement.
The key technology of this class preparation is the use of disintegrating agent.In general, under identical prescription, process conditions, the hardness of tablet is more little, friability is big more, and then disintegrate is fast more.But suitability for industrialized production requires tablet can keep suitable hardness and less friability, just might realize.So concern between the disintegration time of this class preparation high spot reviews tablet, hardness, the friability three, seek suitable equilibrium point, make tablet disintegrate rapidly, can keep suitable hardness and less friability again, to satisfy industrial requirement.In most of the cases, within the specific limits, disintegrating agent adds manyly more, and disintegrate is fast more; But disintegrant content is too high, and tablet is difficult to be shaped, even if it is also frangible to be shaped; Disintegrant content is low excessively, and disintegrate is slowed down, and does not reach the specification requirement of disintegrate in the oral cavity disintegration tablet 1 minute; So need suitable consumption and technology, add the auxiliary disintegrating agent of appropriate amount, for example surfactant, effervescent or the like simultaneously again.
It is fast that the present invention develops disintegration rate, and can keep the multivitamin oral cavity disintegration tablet of necessary intensity; Developing simultaneously can be efficiently, be suitable for the multivitamin oral cavity disintegration tablet of commercial Application.
Not only disintegrate is rapid, mouthfeel is better for this oral cavity disintegration tablet, and certain intensity arranged, do not need special producing condition, equipment and packing, production cost is low, carry, preserve, transport and take all very convenient, be specially adapted to old man, baby or the patient of dysphagia is arranged, and take an excursion in an open country and temporarily can't obtain the personage of drinking-water during the journey.
The present invention adopts abundant mixing such as water soluble vitamins (for example vitamin B1, B2, B6, B12, folic acid, nicotiamide, vitamin C etc.) and filler, disintegrating agent, correctives, effervescent etc., it is an amount of to add binding agent, 20 mesh sieve wet granulations, 40～60 ℃ of dryings 40～60 minutes, directly add fatsoluble vitamin microcapsule (for example vitamin A, D, E) and part disintegrating agent, correctives, fluidizer, lubricant again, cross 30 mesh sieve granulate, the method for tabletting prepares multi vitamin oral disintegrating tablet behind the mix homogeneously.Also vitamin raw materials can be anticipated, mix the back direct compression again with suitable premixing auxiliary material, for example with commercially available vitamin A, D, E microcapsule and the granulous adjuvant mixing direct compression for preparing in advance.
Used principal agent composition (if health food among the present invention, then be referred to as functional component) be multivitamin combination, comprise the combination of water soluble vitamins, the combination of fatsoluble vitamin or the combination of part water soluble vitamins and part fatsoluble vitamin, wherein water soluble vitamins comprises vitamin B1, B2, B6, B12, folic acid, nicotiamide, calcium pantothenate, vitamin C etc., and fatsoluble vitamin comprises vitamin A, D, E, beta-carotene etc.; Every middle vitamins total content be several milligrams to the hundreds of milligram, generally in 200 milligrams.
Filler comprises mannitol, xylitol, sorbitol (while is the double as correctives also), lactose, microcrystalline Cellulose, glucose, partially pregelatinized starch etc. among the present invention, and consumption is generally 20%～60%, and optimum amount is 30%～50%.
Disintegrating agent comprises crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium and low-substituted hydroxypropyl cellulose etc. among the present invention, can singly use, also can applied in any combination, consumption is generally 10%～40%, and optimum amount is 20%～30%.
Effervescent includes, but are not limited to the acid-base pair that citric acid, tartaric acid, malic acid and other organic acid and sodium bicarbonate, sodium carbonate etc. are formed among the present invention, and use amount is 0～32% in this prescription, and optimum amount is 10%～20%.In addition, organic acid can also promote salivation, thereby accelerates the disintegrate of tablet in the oral cavity.In fact, effervescent also is a kind of disintegrating agent in a broad sense.
The present invention can also the conduct of option table surface-active agent assist disintegrating agent, and surfactant can be selected sodium lauryl sulphate, poloxamer, poly yamanashi esters etc.
Binding agent comprises hydroxypropyl emthylcellulose, polyvinylpyrrolidone, pregelatinized Starch, polyacrylic resin, arabic gum, pectin or the like among the present invention, can singly use, also can applied in any combination, consumption is generally 0.4%～10%, and optimum amount is 0.8%～5%.
Correctives comprises sweeting agent, essence and coloring agent among the present invention.Wherein sweeting agent can select that A Siba is sweet, steviosin, acesulfame potassium, saccharin sodium etc.; Essence can be selected lemon, mint flavored, orange flavor, Citrus flavor etc. for use, to satisfy the needs of crowd's different taste; Can select the different colours coloring agent for use according to client's demand, for example edible yellow, edible indigo plant, carmine etc. also can not add coloring agent certainly.
Lubricant can be selected magnesium stearate, Stepanol MG, Rikemal B 200, solid polyethylene glycol class or the like among the present invention, is playing under the lubrication, and consumption is the least possible, and consumption is generally 0.05%～5%, and optimum amount is 0.1%～3%.In addition, can select micropowder silica gel, improve the flowability of powder as fluidizer; Also can select for use a spot of Pulvis Talci to use as antitack agent.
The specific embodiment
The following examples can illustrate in greater detail the present invention, but the present invention is not limited only to the scope of these embodiment.
Embodiment 1
Embodiment 2
Embodiment 3
Embodiment 4
Embodiment 5
Embodiment 6
Embodiment 7
Embodiment 8
Embodiment 9
[slaking test]
1. disintegration time in the water
Get 1, put in the 250ml beaker, fill 100ml water in the beaker, water temperature is 20 ± 1 ℃, rotates beaker gently, and until disintegrate, be dispersed in the water, it is left not have accumulative granule, is recorded as disintegration time in water.Test is carried out 6 times, lists its minima, maximum and meansigma methods.
2. intraoral disintegration time
Measure tablet and in the healthy adult human mouth, reach the time that is badly deformed, as disintegration time.Test is carried out 3 times, lists its minima, maximum and meansigma methods.
3. the disintegration time that records with disintegration tester
Detect according to Chinese Pharmacopoeia two appendix XA of version in 2000 " inspection technique disintegration ".
[friability] detects according to two appendix XG of Chinese Pharmacopoeia version in 2000 " tablet friability inspection technique ".
Table 1
Y
1: commercially available vitamin C effervescent tablet, Germany produces, the circular sheet about 4.8 grams, hardness is bigger
Y
2: commercially available multivitamin effervescent tablet, Germany produces, the circular sheet about 4.5 grams, hardness is bigger
About A:1 minute the beginning cracked, whole splinters in the time of 4 minutes
B: undesirable in view of friability, do not survey hardness, only it is freely fallen from 2 meters eminences, all there is breakage at the edge
This product can also join in the spoon meats such as fruit juice or soup and take except that common oral administration, and is to be easy to very much the preparation taken.Therefore, oral cavity disintegration tablet of the present invention is not only applicable to children's, old man and the dysphagia patien is arranged, after normal adult human is on probation, since its taking convenience, also glad probably taking.
The present invention adopts common pressed-disc technique to prepare the multivitamin oral cavity disintegration tablet, for example wet granule compression tablet technology or direct compression technology, do not need special producing condition, equipment, simplify the preparation technology of oral cavity disintegration tablet, overcome complex process in the conventional art, defective that production cost is high, helped the industrialization of multivitamin oral cavity disintegration tablet.
Claims (5)
1. multi vitamin oral disintegrating tablet, it is characterized in that: its composition is by weight percentage:
Multivitamin combination 5～30%;
Filler 20～60%, filler are the combination of microcrystalline Cellulose, lactose and mannitol, the combination of the combination of microcrystalline Cellulose, lactose, xylitol and dextrin or microcrystalline Cellulose, lactose, mannitol and dextrin;
Disintegrating agent 10～40%, disintegrating agent are the combination of crospolyvinylpyrrolidone or crospolyvinylpyrrolidone and low-substituted hydroxypropyl methylcellulose;
Effervescent 0～32%, the effervescent acid-base pair that to be citric acid, tartaric acid or malic acid form with sodium bicarbonate or sodium carbonate;
Correctives 1～10%, correctives are mannitol, essence and A Siba one or more the combination in sweet;
Binding agent 0.4～10%, binding agent are one or more the combination in hydroxypropyl emthylcellulose, polyvinylpyrrolidone, pregelatinized Starch, polyacrylic resin, arabic gum and the pectin;
Lubricant 0.05～5%, lubricant are a kind of in magnesium stearate, polyethylene glycol 6000, Pulvis Talci, Stepanol MG and the micropowder silica gel;
More than various composition sums be 100%.
2. multi vitamin oral disintegrating tablet as claimed in claim 1, it is characterized in that: described multivitamin the be combined as combination of water soluble vitamins, the combination of fatsoluble vitamin or the combination of part water soluble vitamins and part fatsoluble vitamin, wherein water soluble vitamins comprises vitamin B1, B2, B6, B12, folic acid, nicotiamide, calcium pantothenate, vitamin C, and fatsoluble vitamin comprises vitamin A, D, E, beta-carotene.
3. multi vitamin oral disintegrating tablet as claimed in claim 2, it is characterized in that: vitamin B1, B2, B6 content are at 0.1mg～10mg, vitamin B12 content is at 0.1 μ g～10 μ g, folate content is at 10 μ g～500 μ g, niacinamide content is at 1.0mg～20mg, calcium pantothenate content is at 1.0mg～20mg, Vitamin C content is at 10mg～120mg, vitamin A content is in 1000～5000 ius, vitamin D content is in 100～1000 ius, and content of vitamin E is in 1～100 iu.
4. multi vitamin oral disintegrating tablet as claimed in claim 1 is characterized in that: the option table surface-active agent is as auxiliary disintegrating agent, and surfactant is a kind of in sodium lauryl sulphate, poloxamer and the Polysorbate.
5. prepare the method for multi vitamin oral disintegrating tablet as claimed in claim 1, it is characterized in that: adopt common pressed-disc technique prepared multivitamin oral cavity disintegration tablet, i.e. wet granule compression tablet technology or direct compression technology.
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| CN101352449B (en) * | 2007-07-27 | 2013-01-16 | 杭州赛诺菲民生健康药业有限公司 | Vitamin orally disintegrating tablet and preparation method thereof |
| CN104582700B (en) * | 2012-11-13 | 2021-01-05 | 因维克特斯生物技术有限公司 | Transmucosal delivery of tocotrienols |
| WO2016107605A1 (en) * | 2014-12-31 | 2016-07-07 | 昆明积大制药股份有限公司 | Pharmaceutical composition and preparation method therefor |
| CN106617046A (en) * | 2016-09-26 | 2017-05-10 | 广东工业大学 | Phloretin orally disintegrating tablet and preparation method thereof |
| CN107348216A (en) * | 2017-07-31 | 2017-11-17 | 安徽省金安禽业有限公司 | A kind of preparation method of food stuff for chicken laying vitamin and minerals premix |
| CN108451914A (en) * | 2018-05-31 | 2018-08-28 | 南京中生生物科技有限公司 | A kind of vitamin C oral disintegration tablet |
| CN109528679B (en) * | 2019-01-15 | 2023-03-14 | 南宁富莱欣生物科技有限公司 | Soft capsule containing multiple vitamins and production method thereof |
| CN111481516A (en) * | 2020-04-09 | 2020-08-04 | 江苏海悦康医药科技有限公司 | Medicinal composition containing vitamin B1 and preparation method thereof |
| CN115517366B (en) * | 2022-11-02 | 2024-04-02 | 宝健（北京）生物技术有限公司 | A spirulina tablet for shortening disintegration time and relieving beta-carotene attenuation, and its preparation method |
| CN115644424A (en) * | 2022-11-15 | 2023-01-31 | 合肥工业大学 | Volvariella volvacea vitamin D 2 Nutrition-enriched tablet and its preparing method |
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