CN1754549A - 一种虫草制剂的制备方法 - Google Patents
一种虫草制剂的制备方法 Download PDFInfo
- Publication number
- CN1754549A CN1754549A CN 200410080270 CN200410080270A CN1754549A CN 1754549 A CN1754549 A CN 1754549A CN 200410080270 CN200410080270 CN 200410080270 CN 200410080270 A CN200410080270 A CN 200410080270A CN 1754549 A CN1754549 A CN 1754549A
- Authority
- CN
- China
- Prior art keywords
- preparation
- cordyceps
- caterpillar fungus
- chinese caterpillar
- dry extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 241000233866 Fungi Species 0.000 title claims abstract description 23
- 240000001307 Myosotis scorpioides Species 0.000 title claims abstract description 23
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 238000001035 drying Methods 0.000 claims abstract description 14
- 239000007901 soft capsule Substances 0.000 claims abstract description 13
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 239000006187 pill Substances 0.000 claims abstract description 8
- 239000003826 tablet Substances 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 5
- 239000006196 drop Substances 0.000 claims abstract description 3
- 241000190633 Cordyceps Species 0.000 claims description 44
- 239000002826 coolant Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 238000001556 precipitation Methods 0.000 claims description 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 108010010803 Gelatin Proteins 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 238000007908 dry granulation Methods 0.000 claims description 6
- 239000008273 gelatin Substances 0.000 claims description 6
- 229920000159 gelatin Polymers 0.000 claims description 6
- 235000019322 gelatine Nutrition 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 235000012907 honey Nutrition 0.000 claims description 6
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 6
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 229920002545 silicone oil Polymers 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000005550 wet granulation Methods 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- 239000008188 pellet Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 102000011759 adducin Human genes 0.000 claims description 3
- 108010076723 adducin Proteins 0.000 claims description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000008157 edible vegetable oil Substances 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 238000000151 deposition Methods 0.000 abstract description 5
- 238000001914 filtration Methods 0.000 abstract description 3
- 239000002552 dosage form Substances 0.000 abstract description 2
- 238000009835 boiling Methods 0.000 abstract 1
- 230000006837 decompression Effects 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000014347 soups Nutrition 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 101100433727 Caenorhabditis elegans got-1.2 gene Proteins 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100802704A CN100553623C (zh) | 2004-09-29 | 2004-09-29 | 一种虫草制剂的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100802704A CN100553623C (zh) | 2004-09-29 | 2004-09-29 | 一种虫草制剂的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1754549A true CN1754549A (zh) | 2006-04-05 |
CN100553623C CN100553623C (zh) | 2009-10-28 |
Family
ID=36688281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100802704A Active CN100553623C (zh) | 2004-09-29 | 2004-09-29 | 一种虫草制剂的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100553623C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103432172A (zh) * | 2013-08-23 | 2013-12-11 | 周秋火 | 虫草片剂 |
CN108245490A (zh) * | 2017-12-27 | 2018-07-06 | 江西济民可信药业有限公司 | 一种含有发酵虫草菌粉(Cs-4)的固体分散体及其片剂制备方法 |
CN113616611A (zh) * | 2021-08-24 | 2021-11-09 | 江西济民可信药业有限公司 | 一种含发酵虫草菌粉cs-4片剂的制备方法 |
-
2004
- 2004-09-29 CN CNB2004100802704A patent/CN100553623C/zh active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103432172A (zh) * | 2013-08-23 | 2013-12-11 | 周秋火 | 虫草片剂 |
CN108245490A (zh) * | 2017-12-27 | 2018-07-06 | 江西济民可信药业有限公司 | 一种含有发酵虫草菌粉(Cs-4)的固体分散体及其片剂制备方法 |
CN108245490B (zh) * | 2017-12-27 | 2020-08-28 | 江西济民可信药业有限公司 | 一种含有发酵虫草菌粉(Cs-4)的固体分散体及其片剂制备方法 |
CN113616611A (zh) * | 2021-08-24 | 2021-11-09 | 江西济民可信药业有限公司 | 一种含发酵虫草菌粉cs-4片剂的制备方法 |
CN113616611B (zh) * | 2021-08-24 | 2022-11-11 | 江西济民可信药业有限公司 | 一种含发酵虫草菌粉cs-4片剂的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100553623C (zh) | 2009-10-28 |
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Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20090306 Address after: 888, seven hi tech Road, hi tech Zone, Jiangxi, Nanchang Province, China: 330029 Applicant after: Jiangxi Jimin Kexin Jinshuibao Pharmaceutical Co., Ltd. Address before: 888, seven hi tech Road, hi tech Zone, Jiangxi, Nanchang Province, China: 330029 Applicant before: Li Yihai |
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ASS | Succession or assignment of patent right |
Owner name: JIANGXI JIMINKEXIN JINSHUIBAO PHARMACEUTICAL CO., Free format text: FORMER OWNER: LI YIHAI Effective date: 20090306 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: 330096 No. seven, No. 888, hi tech Zone, Nanchang hi tech Zone, Jiangxi Patentee after: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Address before: 330029 No. seven, No. 888, hi tech Zone, Nanchang hi tech Zone, Jiangxi Patentee before: JIANGXI JIMINKEXIN JINSHUIBAO PHARMACEUTICAL Co.,Ltd. |
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CP03 | Change of name, title or address |