CN1747716A - Compositions comprising a plurality of particles or agglomerates having a defined particle size - Google Patents
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- CN1747716A CN1747716A CN 200480003711 CN200480003711A CN1747716A CN 1747716 A CN1747716 A CN 1747716A CN 200480003711 CN200480003711 CN 200480003711 CN 200480003711 A CN200480003711 A CN 200480003711A CN 1747716 A CN1747716 A CN 1747716A
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Abstract
The invention provides a compound which comprises an extraction part of semen plantaginis combined with one adhesive or edible acid or a plurality of adhesives or edible acids, in particular relating to a compound which comprises polysaccharide components, and the polysaccharide components contain xylose and arabinose, wherein, the proportion of the xylose and the arabinose is at least approximately 3 to 1 by weight, and polysaccharide particles are provided with mean diameter distribution from approximately 0.001 micrometers to approximately 150 micrometers. The compound comprises a plurality of agglomerates containing polysaccharide components and dispersed components in another embodiment, wherein, the dispersed components are selected from adhesives, suspending agents, edible acids and mixture of the adhesives, the suspending agents and the edible acids.The compound comprises agglomerates containing polysaccharide components in another embodiment, wherein, the agglomerates are provided with mean diameter distribution from approximately 100 micrometers to approximately 500 micrometers. The compounds of the invention can be used for various treatments which comprise treatment of enterogastric diseases or supply of other enterogastric effects.
Description
Invention field
The present invention relates to be used for the treatment of the compositions of gastroenteropathy.Specifically, the present invention relates to comprise the compositions of defined polysaccharide component, this component is mixed with granule or agglomerate uniquely, so that it is easy to mix with liquid, aqueous, and is suitable for light and desirable the taking of consumer.Said composition can be used for multiple treatment, and these treatments comprise, for example, make intestinal function normal, induce hypocatharsis, reduce serum cholesterol content, and treat other gastroenteropathy.
Background of invention
The product that contains psyllium is widely used in and makes intestinal function normal and induce hypocatharsis.Show that also psyllium can effectively reduce human serum cholesterol level and control of diabetes people's blood sugar content.These beneficial effects typical case obtains by the psyllium of ingesting, and this psyllium derives from the kind skin of Plantago L. class plant.In order to reach the hypocatharsis effect, the typical doses that psyllium is used for the people is extremely about 20 grams of about 2.5 grams, takes every day about 1 to about 3 times.In order to take so a large amount of psyllium, usually shell is ground or grinds, be distributed to subsequently in water or the aqueous drink by edible (for example, the Procter ﹠amp of user; The METAMUCIL that Gamble Company sells
).In order to reduce the microbial contamination of psyllium, except grinding, typically before carrying out any further processing, also need psyllium is carried out disinfection.Higher and the operating difficulties of this sterilisation step opportunity cost.
Psyllium comprises and the natural mucilage that can form spawn after water contacts.As a result, because granule may be tending towards agglomeration, the milled psyllium seed husk that surface area increases shows to have very weak dispersibility and Combination in water.On agglomerant aggregate surface hydration takes place, form the agglomerate that gel coats, still do basically agglomerate inside.These agglomerates are very difficult to disperse.Used several different methods to improve the dispersibility of milled psyllium seed husk in water-bearing media.For example, United States Patent (USP) 5,425,945 disclose the beverage mix composition that comprises the agglomeration psyllium, and wherein edible acid spreads all over agglomeration coating homodisperse, with Combination and the dispersibility that is improved.
Yet in case be distributed in the aqueous solution, rapid hydration of agglomerant psyllium and the increase that is accompanied by drink soln viscosity form gel.In addition, used several different methods to reduce this gelation rate and the product of aesthetic pleasant is provided.United States Patent (USP) 5,356,618 propose, and calcium cirate malate is joined in the compositions that comprises milled psyllium seed husk, and the gelation rate of shell slows down in the time of can causing with aqueous solution.Yet although these improvement are arranged, consumer (less than about two minutes) typically in the short period of time finishes off liquid, to avoid having to drink aesthetic not pleasant, full-bodied liquid.
Sterilization, ground psyllium have been impregnated in baked goods, in sweet cake, cookies and similar food product, with the preparation solid dosage forms.Yet the rapid gelling of psyllium may be obviously same in these preparations.When edible, the baked goods that contains this psyllium has the agglomerative trend of beginning in mouth, cause mouthfeel not good and not attractive in appearance.Usually be necessary when eating this baked goods, to drink big water gaging or liquid, aqueous so that swallow.In addition, in order to send the psyllium of effective dose, the size of this solid psyllium preparation must be big or, alternatively, must edible a plurality of preparations.Therefore, still need a kind of compositions that contains Semen Plantaginis of taking easily, easily and having the attractive in appearance and mouthfeel of improvement.
The Semen Plantaginis product that contains of other type comprises having the tablet swallowed that can accept dissolution properties, thereby avoids the not good problem of mouthfeel.United States Patent (USP) 4,999,200 have proposed to comprise the tablet swallowed of Semen Plantaginis, binding agent, wetting agent and disintegrating agent.Unfortunately, though deglutible Semen Plantaginis tablet is convenient, generally has relatively poor dissolution properties.The same with the powder drink mixture, in case put into aqueous environment will on the surface of pill hydration take place, form the gel pack coating, and still do basically pill inside.For deglutible pill, this can cause dissolving not exclusively in gastrointestinal tract.
The method that the psyllium fractional distillation is obtained multiple polysaccharide fraction is known.Some fraction of psyllium is sent the treatment beneficial effect the same with psyllium.For example, United States Patent (USP) 6,287,609 propose to obtain from Semen Plantaginis shell the multiple extraction method of three kinds of different fractions, and these fractions comprise alkali dissolution/acid gel fraction, alkali not solvent fraction and sour solvent fraction.Alkali dissolution/acid gel fraction is compared with not fractionated psyllium has slower gelation rate.Yet, in the desirable product of consumer, in the suitable preparation of these fractions, still have challenge.
Through after the important process to the desirable product that contains some fraction of psyllium of consumer; the present inventor finds; comprise the compositions that has the defined particle size granule or have the defined particle size agglomerate, fabulous characteristic can be provided, especially before edible, be diluted in the liquid, aqueous compositions.Specifically, be surprisingly found out that, comprise the xylose that limits ratio and the compositions of arabinose with defined particle size, can be randomly as with the agglomerate of binding agent or edible acid combination, when be dispersed in liquid, aqueous in the time good mouthfeel can be provided, in this is liquid, aqueous, form good dispersion, and compare in this is liquid, aqueous the precipitation that the past along with the time produces with psyllium and reduce.These and other embodiment of the present invention and beneficial effect will describe in detail hereinafter.
Summary of the invention
The present invention relates to comprise the extraction part and one or more binding agents or the bonded compositions of edible acid of plantago seed.Specifically, the present invention relates to comprise the compositions of polysaccharide component, this polysaccharide component comprises xylose and arabinose, and wherein the ratio of xylose and arabinose is at least about 3: 1 by weight, and wherein this polyoses grain have about 0.001 micron to about 150 microns average particle size distribution.In another embodiment, said composition comprises a plurality of agglomerates that contain polysaccharide component and dispersed component, and this dispersed component is selected from binding agent, suspending agent, edible acid and their mixture.In another embodiment, said composition comprises the agglomerate that contains polysaccharide component, and wherein this agglomerate has about 100 to about 500 microns average particle size distribution.
Compositions of the present invention can be used for multiple treatment beneficial effect, and being included as gastroenteropathy provides treatment or other the intestines and stomach beneficial effect is provided.This paper has described the method that following beneficial effect is provided, these beneficial effects be selected from make intestinal function normal, induce hypocatharsis, dietary fiber is provided, reduces serum cholesterol content and their combination, wherein these methods comprise:
(a) foregoing is mixed to form product with liquid, aqueous; With
(b) oral this product.
Detailed Description Of The Invention
Running through this disclosure has enumerated and has comprised for example various kinds of document of publication and patent.All these documents are incorporated herein by reference.
Except as otherwise noted, all percentage ratios and ratio are all calculated by weight.Except as otherwise noted, all percentage ratios and ratio all calculate based on total composition.
What this paper quoted is the trade name of the used component that comprises multiple composition of the present invention.The inventor of this paper is not intended to be limited to the material of a certain trade name.Can be substituted and be used for the description of this paper with the material of those material equivalences of mentioning with trade name (for example, those materials that obtain from the difference source with different titles or reference number).
Multiple embodiments and/or individual characteristics are disclosed in description of the invention.It is evident that for the person of ordinary skill of the art all combinations of these embodiments and feature all are possible, and can cause preferred enforcement of the present invention.
The compositions of this paper can comprise, basically by or form by any key element described herein.
Though illustrate and described multiple embodiments of the present invention and individual characteristics, under the situation that does not deviate from the spirit and scope of the present invention, can it is carried out multiple other change and modification.It is evident that also the embodiment that proposes in the aforementioned disclosure and all of feature combinations all are possible, and can cause preferred enforcement of the present invention.
Compositions of the present invention
The present invention relates to comprise the part psyllium and have the granule that limits average particle size distribution or a compositions of optional agglomerate as a plurality of.Specifically, in one embodiment, the present invention relates to the compositions of a plurality of polyoses grains, wherein this polyoses grain comprises the polysaccharide component that contains xylose and arabinose, wherein by weight, the ratio of xylose and arabinose is at least about 3: 1, and wherein this polyoses grain have about 0.001 micron to about 150 microns average particle size distribution.In another embodiment, said composition comprises a plurality of agglomerates, wherein this agglomerate comprises the polysaccharide component that contains xylose and arabinose, wherein the ratio of xylose and arabinose is at least about 3: 1 by weight, and wherein this agglomerate have about 100 microns to about 500 microns average particle size distribution.As used herein; and also be this area institute common sense; the term " average particle size distribution " that relates to granule or agglomerate (suitable) is meant; be present in the granule in the compositions or the meansigma methods of agglomerate (respectively), this value is based on the particle diameter of individual particle in the compositions or agglomerate (respectively).(Horiba CA), or provides the Other Instruments of similar results basically, measures the average particle size distribution of granule or agglomerate (suitable) to use HORIBA LA-910 laser light scattering particle size distribution analyser.
Therefore, in various embodiments of the present invention, said composition can comprise the granule that contains xylose and arabinose, or alternatively comprises the agglomerate that contains xylose and arabinose.Term used herein " agglomerate " comprises a plurality of granules, wherein different with remainder particulate on forming to the small part granule, wherein this particle agglomeration becomes the discrete bodies of material together, and wherein individual particle physically reversibly combines, and forms the main body of material.
It has been observed by the present inventors that, comprise at least a portion polysaccharide component and have the granule or the optional agglomerate of defined particle size, can cause dispersing or dissolving, aspect mouthfeel or the antisolvent precipitation, having even the multiple beneficial effect.
Compositions described herein needs polysaccharide component as described below:
Polysaccharide component
Various embodiments of the present invention comprise polysaccharide component.Polysaccharide component comprises xylose and arabinose, and wherein the ratio of xylose and arabinose is at least about 3: 1 by weight.In alternative embodiment, compositions of the present invention comprises xylose and arabinose, and wherein the ratio of xylose and arabinose is at least about 3.3: 1 or by weight at least about 3.6: 1.In other embodiments, compositions of the present invention comprises xylose and arabinose, and wherein the ratio of xylose and arabinose is about 3: 1 to about 4.5: 1 by weight, or about 3: 1 to about 4: 1.
Polysaccharide component randomly comprises the xylose by the weight of described polysaccharide component about 55% to about 70%.Polysaccharide component also can randomly comprise the arabinose by the weight of described polysaccharide component about 15% to about 20%.
Polysaccharide component also can randomly comprise the component that is selected from galactose, glucose, alduronic acid and their mixture.With respect to xylose and arabinose, these components can exist by low content.
For example, polysaccharide component can randomly comprise weight by described polysaccharide component be less than about 2%, or about 1% to about 2% galactose.
As another embodiment, polysaccharide component can randomly comprise weight by described polysaccharide component be less than about 2%, or about 0.01% to about 1% glucose.
As another embodiment, polysaccharide component can randomly comprise and is less than approximately 20%, or about 1% to about 10%, or about 0.1% to about 5% alduronic acid, and wherein said percentage ratio is all by the weight of described polysaccharide component.
In another embodiment of this paper, polysaccharide component comprises xylose and galactose, and wherein the ratio of xylose and galactose is greater than about 25: 1, or greater than about 30: 1, or greater than about 35: 1.
In another embodiment of this paper, polysaccharide component comprises xylose and alduronic acid, and wherein the ratio of xylose and alduronic acid is by weight greater than about 5: 1, or greater than about 10: 1, or greater than about 15: 1.
Polysaccharide component can randomly also comprise the component that is selected from rhamnose, mannose and their mixture.
Other embodiment preferred comprises those polysaccharide components, and this polysaccharide component comprises one or both, or part be described in United States Patent (USP) 6,287,609 fraction B or C.
The present invention can randomly comprise about 10% to about 90% polysaccharide component, or about 20% to about 40% polysaccharide component, or about 20% to about 50% polysaccharide component, or about 20% to about 60% polysaccharide component, or about 20% to about 70% polysaccharide component, or about 20% to about 80% polysaccharide component, or about 30% to about 70% polysaccharide component.
In one embodiment of the invention, compositions comprises a plurality of polyoses grains, and wherein this polyoses grain comprises polysaccharide component, and wherein this polyoses grain have about 0.001 micron to about 150 microns average particle size distribution.In another embodiment, this polyoses grain have about 0.1 micron to about 125 microns or about 1 micron to about 100 microns average particle size distribution.
In this embodiment of the present invention, compositions comprises polyoses grain, and wherein this granule has the average particle size distribution of qualification.Polyoses grain can freely be dispersed in the whole compositions, or other particles coalesce that can be different with composition is to form agglomerate.Thereby this polyoses grain can have an average particle size distribution, and can be randomly coalescent, the agglomerate that has another average particle size distribution with formation, as hereinafter subsequently as described in.
Agglomerate
As mentioned above, this paper compositions can comprise a plurality of agglomerates, and wherein this agglomerate comprises polysaccharide component.In this embodiment, this agglomerate can comprise a plurality of polyoses grains that contain polysaccharide component, and wherein this polyoses grain randomly has average particle size distribution as indicated above.
In fact, in this article, it has been observed by the present inventors that, comprise to the agglomerate of small part polysaccharide component and can be merged forming agglomerate, dispersing or dissolving, providing even more beneficial effect aspect mouthfeel or the antisolvent precipitation.
Specifically, find, most preferred agglomerate have about 100 microns to about 500 microns particle diameter.In this paper compositions, preferably comprise have average particle size distribution be about 100 microns to about 400 microns or about 125 microns to about 350 microns or about 150 microns to about 320 microns agglomerate.
In a preferred embodiment about agglomerate, except polysaccharide component, agglomerate preferably also comprises dispersed component.Because on physical property, dispersed component can randomly be different from agglomerate, therefore will relate to hereinafter in the part of optional components dispersed component is described.However, in the especially preferred embodiment of this paper, agglomerate preferably comprises dispersed component.
The polysaccharide component to multiple content is described, and it can be by reference, and wherein said composition comprises agglomerate.In another preferred embodiment of finding according to this paper, agglomerate comprises the various polysaccharide components that further define content.
In one embodiment, agglomerate comprises about 10% to about 90% xylose and arabinose, or about 20% to about 80% xylose and arabinose, or about 30% to about 70% xylose and arabinose, wherein said percentage ratio are all by the weight of described agglomerate.
As used herein, agglomerate be based on the whole agglomerates that exist in the compositions with reference to the multiple content of composition, rather than based on every kind that exists in the compositions discrete agglomerate.For example, wherein " agglomerate comprises about 10% to about 90% xylose and arabinose by the weight of described agglomerate ", this is meant all whole agglomerates of existing in compositions weight by described whole agglomerates, comprises about 10% to about 90% xylose and arabinose.Because the content of multiple composition can be different with the difference of agglomerate, this term is not to be intended to refer to that every kind of indivedual agglomerates must comprise xylose and the arabinose by the weight of described indivedual agglomerates about 10% to about 90%.
Other optional components
Compositions can comprise other optional components, and is as described below.These components can be used as the part of optional agglomerate, or occur as being contained in other component in the compositions.
Dispersed component
The present composition can comprise dispersed component, and this dispersed component is selected from binding agent, suspending agent, edible acid and their mixture.Through after the important process to the desirable product of more consumers, the present inventor finds to comprise some and limits component and can be used for this purpose, especially is diluted in the liquid, aqueous compositions before edible wanting.Specifically, it has been observed by the present inventors that, comprise dispersed component as defined herein, can disperse or dissolve, mouthfeel or opposing mix aspect the precipitation that is produced with liquid, aqueous, and good properties is provided.The discovery of these character forms, and with respect to the compositions that contained psyllium in the past, more makes the desirable product of consumer.
This agglomerate can comprise dispersed component; Alternatively or can be additionally, said composition can comprise dispersed components different with agglomerate on the physical property.In embodiment preferred of this paper, agglomerate comprises dispersed component.
As used herein, this dispersed component is selected from binding agent, suspending agent, edible acid and their mixture.All will know for each of these components of those of ordinary skill, in any case, embodiment hereinafter is provided.
Binding agent is known in the art.The embodiment that can be used for this paper purpose binding agent is found to be polyhydric alcohol, starch, natural gum or their mixture.Polyhydric alcohol and starch especially are preferred for this paper.
Polyhydric alcohol comprises sugar alcohol, for example disaccharide and complexation carbohydrate.Some complexation carbohydrate is commonly called starch.Disaccharide is general molecular formula C
nH2
N-2O
N-1Molecule, wherein disaccharide contains 2 monosaccharide units that connect by glycosidic bond.In the formula, n is equal to or greater than 3 integer.This paper can comprise sucrose, maltose, lactose, maltose alcohol, maltulose and lactose with the embodiment of disaccharide.
The complexation carbohydrate comprises oligosaccharide and polysaccharide.Term used herein " oligosaccharide " is meant and contains 3 molecules to 9 monosaccharide units that wherein these unit link to each other by the glycosidic bond covalency.Term used herein " polysaccharide " is meant the macromole that contains more than 9 monosaccharide units, and wherein these unit link to each other by the glycosidic bond covalency.Polysaccharide can be straight or branched.Preferably, polysaccharide contains 9 to 20 monosaccharide units.Polysaccharide can comprise starch, and this paper is defined as and comprises starch and modified starch.Starch is generally the carbohydrate polymer that is present in the certain plants class, for example, frumentum and tuber, such as corn, Semen Tritici aestivi, rice, Maninot esculenta crantz., Rhizoma Solani tuber osi, Semen Pisi sativi, or the like.Starch comprises the alpha-D-glucose unit of connection.Starch can mainly have linear chain structure (for example, amylose) or branched structure (for example, amylopectin).Can use method well-known to those having ordinary skill in the art by crosslinked, to prevent the starch granules overinflation to starch conversion.
The embodiment of preferred complexation carbohydrate comprises Raffinose, stachyose, maltotriose, maltotetraose, glycogen, amylose, amylopectin, dextrosan and maltodextrin.Most preferred complexation carbohydrate and in fact most preferred binding agent are maltodextrins.Other embodiment of starch comprises, potato starch, corn starch, or the like.Other embodiment of commercially available starch comprises ULTRA SPERSE M, ULTRA SPERSE 2000, N-LITE LP and TEXTRA PLUS, all available from National Starch and Chemical Company, Bridgewater, NJ.
Compositions of the present invention can randomly comprise the binding agent by the weight of described compositions about 1% to about 50%.In another embodiment, compositions comprises about 10% to about binding agent of 40%, alternatively about 20% to about 30%, and wherein said percentage ratio is all by the weight of described compositions.When agglomerate comprises binding agent, this agglomerate can randomly comprise about 10% to about 90% binding agent, or about 10% to about 60% binding agent, or about 20% to about 50% binding agent, or about 30% to about 40% binding agent, wherein said percentage ratio is all by the weight of described agglomerate.
Suspending agent also is known in the art.Natural gum comprises other hydrocolloid, also can be used as suspending agent.Term used herein " hydrocolloid natural gum " or simple " natural gum " are meant the polysaccharide of plant or microorganism or their derivant, and they can be scattered in cold water or hot water, to produce heavy-gravity mixture or solution.The embodiment of natural gum comprises thorn kidney bean glue, gellan gum, guar gum, xanthan gum, Radix Acaciae senegalis, ghatti gum, Tragacanth, locust bean gum, carboxymethyl cellulose, alginate esters, or the like.Particularly preferred natural gum comprises thorn kidney bean glue and guar gum.
Compositions of the present invention can randomly comprise the suspending agent by the weight of described compositions about 0.001% to about 20%.In another embodiment, compositions comprises about 0.1% to about suspending agent of 10%, alternatively about 0.5% to about 5%, and alternatively about 1% to about 3% suspending agent, wherein said percentage ratio are all by the weight of described compositions.When agglomerate comprises suspending agent, this agglomerate can randomly comprise about 10% to about 90% suspending agent, or about 10% to about 60% suspending agent, or about 20% to about 50% suspending agent, or about 30% to about 40% suspending agent, wherein said percentage ratio is all by the weight of described agglomerate.
Except binding agent or suspending agent, or alternatively be edible acid.Find according to this paper,, comprise edible acid help the to slow down gelation rate of this component when this paper polysaccharide component during with liquid, aqueous the mixing.Edible acid is generally known in the art, comprises being used for the oral acid of mammalian safe.The embodiment of edible acid comprises lactic acid, citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid, succinic acid and their mixture.In one embodiment, the source of edible acid is selected from citric acid, malic acid, tartaric acid, fumaric acid, succinic acid and their mixture.In another embodiment, the source of edible acid is a citric acid.
Compositions of the present invention typically comprises the edible acid of lower content.For example, the compositions weight that can comprise by described compositions is less than about 10% edible acid.In another embodiment, compositions comprises 0% to about 8%, or about 0.001% to about 5%, or about 0.01% to about 3% edible acid, and wherein said percentage ratio is all by the weight of described compositions.This agglomerate can randomly comprise 0% to about 10% edible acid, or about 0.001% to about 8% edible acid, or about 1% to about 6% edible acid, or about 4% to about 6% edible acid, and wherein said percentage ratio is all by the weight of described agglomerate.
Optional surrounding layer
In the embodiment of this paper, when using agglomerate, this agglomerate can comprise one or more surrounding layers.In this embodiment, one or more surrounding layers that this agglomerate can comprise kernel and be connected in kernel, wherein kernel comprises a kind of in polysaccharide component and the dispersed component at least.Term used herein " is connected to ", " being connected to kernel " etc. is meant in one way around kernel and makes described layer and kernel itself, anterior layer or back layer adjoin.This layer can " be connected to " kernel, anterior layer or back layer, even other material (as another anterior layer or back layer) is got involved.Therefore in fact the layer that " is connected to " on the kernel needn't adjoin with kernel.
Term used herein " adjoins " and is meant by physical force and directly connects, and does not get involved material basically.For example, internal layer can adjoin with kernel (or suitably time be polysaccharide component) and back layer (wherein back layer or another layer or outer).As another embodiment, skin can adjoin with internal layer or another layer.Skin does not adjoin with kernel, because internal layer is an anterior layer with respect to skin.
Term used herein " anterior layer " is meant the layer that is connected to kernel, and with respect to the reference layer that is connected in same kernel more near kernel.For example, internal layer is an anterior layer with respect to skin.
Term used herein " back layer " is meant the layer that is connected on the kernel, still with respect to being connected to reference layer on the same kernel further from kernel.For example, outer is the back layer with respect to internal layer.
Preferably, every layer all is successive.Term used herein " successive " is meant that this reference layer is not interrupted by the space at any point.
In one embodiment, agglomerate comprises kernel and is the surrounding layer of hydrophobic layer, is preferably the continuous hydrophobic layer.Therefore hydrophobic layer comprises one or more materials, thereby hydrophobic layer is hydrophobic.The present inventor has been found that the inclusion of agglomerate comprises such hydrophobic layer, is particularly useful for suppressing final agglomerate absorption water, thereby weakens the ability that agglomerate forms inadvisable gel.When polysaccharide component is surrounding layer (the preferred continuous hydrophobic layer) coating of hydrophobic layer, can obtain these beneficial effects equally.
Of the present invention one preferred but be in the optional embodiments, about hydrophobic being meant of the term of hydrophobic layer, when measuring with the ISO international standard of called after " Sheet Materials-Determination of WaterVapour Transmission Rate-Gravimetric (Dish) Method " (reference number ISO 2528:1995 (E)), hydrophobic layer shows to have less than about 200mg/m
2/ 24 hours Water Vapor TransmissionRate (WVTR).In another embodiment, about hydrophobic being meant of the term of hydrophobic layer, use this standard hydrophobic layer to have less than about 100mg/m
2/ 24 hours Water Vapor TransmissionRate (WVTR).
The embodiment that can be included in the preferred substance in the hydrophobic layer comprises fatty acid, derivative of fatty acid, polymer and their mixture.Most preferably, these materials are hydrophobic, thereby hydrophobic layer becomes hydrophobic by comprising this material.
Derivative of fatty acid can comprise fat (fatty acid glycerine base ester for example, as hydrogenated vegetable oil) and wax (for example animal wax, fossil waxes, vegetable wax, mineral wax or synthetic wax (as Ka Luba wax (carnuba), Cera Flava, angle bean wax, candelilla wax, ceresine, Tissuemat E, paraffin, their mixture, or the like).Especially preferred wax.Polymer can comprise polyvinylpyrrolidone, vinyl acetate, ethyl cellulose, Cellacefate (as AQUATERIC), Cellulose acetotrimellitate, carboxymethylethylcellulose, hydroxypropyl methyl cellulose acetate succinate, hydroxypropyl methyl O-phthalic acid cellulose, their mixture, or the like.Most preferably, skin comprises the material that is selected from fatty acid, derivative of fatty acid and their mixture.
In the optional embodiment of this paper, hydrophobic layer is about 3mg/cm for having coat weight
2To about 25mg/cm
2Continuous coating, 4mg/cm more preferably from about
2To about 20mg/cm
2Coat weight mg/cm as used herein
2Represent, be meant every square centimeter of (cm of reference layer
2) reference layer the milligram number (mg).
In another embodiment, especially when using hydrophobic layer, it is found that hydrophilic layer is extra useful.In fact, enter kernel because hydrophobic layer suppresses the water absorption, hydrophilic layer can be used for further strengthening final agglomerate in the dispersion in liquid, aqueous before the administration.
The embodiment that can be included in the preferred substance of hydrophilic layer comprises that surfactant (for example, TWEENS, SPANS and PLURONICS), natural gum (for example, Radix Acaciae senegalis), inorganic salt (for example, calcium chloride, magnesium sulfate, calcium carbonate, calcium citrate, calcium phosphate, calcium chloride, citric acid-calcium malate, magnesium carbonate, zinc acetate, or the like) and their mixture.Most preferably, these materials are hydrophilic, thereby hydrophilic layer becomes hydrophilic by comprising this material.
When using hydrophobic layer and hydrophilic layer simultaneously, preferred hydrophobic layer is anterior layer (that is, hydrophobic layer with respect to hydrophilic layer more near kernel) with respect to hydrophilic layer.Most preferably, hydrophilic layer is an outermost layer with respect to kernel or polysaccharide component (if suitably).
Other embodiment preferred
The present composition can comprise one or more other components, and those embodiment as mentioned below are used.This component can be used as the part of optional agglomerate, or occurs as the other parts (as being different from the component of agglomerate on the physical property) of compositions.
In especially preferred embodiment of this paper; compositions comprises granule or agglomerate and one or more other components; for example to small part dispersed component mentioned above, wherein granule or agglomerate be different on physical property to this component of small part.In this embodiment, agglomerate and other dry component can be mixed or otherwise mix, to form compositions.
In this type of especially preferred embodiment, compositions comprises starch or natural gum, wherein to this starch of small part or gummy granule or the agglomerate of being different from physical property.In another embodiment, compositions comprises starch and natural gum, wherein to this starch of small part and gummy granule or the agglomerate of being different from physical property.It has been observed by the present inventors that this embodiment is particularly useful for weaken the precipitation that granule or agglomerate produce with liquid, aqueous the mixing time, thereby produces the more product of homogeneous.According to this embodiment, mouthfeel and overall quality also can be enhanced.
The preferred type of said components and the content in whole compositions thereof above are being described in the part about dispersed component.
Can comprise one or more other optional components in the compositions.For example, one or more cellulosic materials, emulsifying agent or lubricant, flavouring agent, pigment, dyestuff, coloring agent and their corresponding color lakes, nutrient substance or sweeting agent can be added into the compositions with further enhancing this paper.The embodiment of these optional components is as follows:
One or more cellulosic materials are particularly useful for the water solublity that strengthens the present composition.Cellulosic material is that this area is extensively known, as by as illustrated in AVICEL, methylcellulose and the sodium carboxymethyl cellulose.
One or more emulsifying agents, surfactant or lubricant can be added into compositions of the present invention.These especially can be useful to the water solublity that strengthens the present composition.Embodiment includes, but not limited to lecithin, Talcum, magnesium stearate, calcium stearate, stearic acid, hydrogenated vegetable oil, Polyethylene Glycol, sodium benzoate, sodium chloride, leucine, sodium lauryl sulfate and lauryl magnesium sulfate.Emulsifying agent, surfactant and lubricant usually exist to be less than about 5% content by the weight of described compositions independently of one another, and are less than about 1% by the weight of described compositions in one embodiment.
Compositions as herein described also can be chosen wantonly and comprise one or more flavouring agents.Flavouring agent can randomly be selected from synthetic perfume liquid and/or the oil and their mixture of leaf derived from plant, flower, fruit etc.Representational spice liquid comprises: vanillin, Salvia japonica Thunb., marjoram, parsley oil, spearmint oil, Oleum Cinnamomi, wintergreen oil (methyl salicylate), Oleum menthae, Oleum Caryophylli, laurel fat, Oleum Anisi Stellati and Eucalyptus oil.Same available is that synthetical, natural or synthetic fruit flavor agent is as comprising the tangerine oil of Fructus Citri Limoniae, Fructus Citri tangerinae, Fructus Musae, Fructus Vitis viniferae, Citrus aurantium Linn., Fructus Pruni and Fructus Citri grandis; With the fruit essence that comprises Fructus Mali pumilae, Fructus Fragariae Ananssae, Fructus Pruni pseudocerasi, Fructus Citri tangerinae, Fructus Ananadis comosi etc.; The flavoring agent of deriving of bean and nut such as coffee bean, cacao bean, cola, peanut, Semen Armeniacae Amarum etc.; And Cortex cinnamomi japonici (Ramulus Cinnamomi), the flavoring agent of Semen Myristicae, Rhizoma Zingiberis Recens and so on, or the like.Flavoring agent can be randomly encapsulated.
Used fragrance dosage is the problem of individual's preference normally, and it depends on the flavor type and the flavor strength factor of for example expectation.Flavouring agent can be impregnated in following one or more in: the coating of the coating of tablet, tablet or single gelation polyoses grain (if using this coating).It is about 4% that the amount that flavouring agent exists reaches, and is about 0.01% to about 3% in one embodiment, is about 0.2% to about 2.5% in another embodiment, and wherein said percentage ratio is all by the weight of described compositions.
Also can comprise one or more pigment, dyestuff, coloring agent and their corresponding color lakes,, make product more can be accepted by consumer to change the outward appearance of this paper compositions.Select suitable content to reach the required special-effect of consumer.The content of pigment and coloring agent can randomly change to about 20% scope about 0.001%, be about 0.01% to about 15% in one embodiment, be about 0.1% to about 10% in another embodiment, wherein said percentage ratio is all by the weight of compositions.
The embodiment of pigment and coloring agent comprises Talcum, Muscovitum, magnesium carbonate, calcium carbonate, magnesium silicate, the aluminium silicate magnesium salt, silicon dioxide, titanium dioxide, zinc oxide, red iron oxide, brown iron oxide, yellow iron oxide, black iron oxide, ammonium ferrocyanide ferrum, bismuth oxychloride, manganese violet, ultramarine pigment, nylon powder, polyethylene powders, the methacrylate powder, the polystyrene powder, the silk powder, crystalline cellulose, starch, the titanate Muscovitum, ferrum oxide metatitanic acid Muscovitum, bismuth oxychloride, FD﹠amp; Red 40, the D﹠amp of C; C red 3,22,28,33 and 36, FD﹠amp; C Huang 5 and 6, D﹠amp; C Huang 10, FD﹠amp; C indigo plant 1 and 2, FD﹠amp; C is green 3, beta-carotene, caramel, cochineal extract, canthaxanthin and their mixture.
In the present composition, can comprise one or more nutrient substance.Nutrient substance comprises mineral, vitamin, oral nutritional supplements, enteral nutritional supplements, herbaceous plant and their mixture.Available mineral comprises calcium, phosphorus, zinc, manganese, potassium, sodium, chromium, cobalt, copper, fluorine, chlorine or chloride, iodine, ferrum, magnesium, molybdenum, selenium, silicon, boron, stannum, vanadium and their mixture.Vitamin can use with mineral, or uses separately.The embodiment of vitamin comprises vitamin A, C, B
6, B
12, D, E and K, thiamine, riboflavin, pantothenic acid, nicotinic acid, folic acid, nicotiamide, bioflavonoids, carnitine, ubiquinone, biotin and their mixture.The embodiment of supplementary comprises aminoacid, lipotropic, fish oil and their mixture.Lipotropic includes but not limited to choline, inositol, betanin, linoleic acid, linolenic acid and their mixture.Fish oil contains a large amount of ω-3 (N-3) polyunsaturated fatty acid, eicosapentaenoic acid and docosahexenoic acid.Enteral nutritional supplements includes but not limited to the triglyceride of protein product, glucose polymer, Semen Maydis oil, safflower oil, medium chain.Herbal embodiment comprises, but be not limited to, Artemisia absinihium L (artemisia absinthium), Radix Artemisia ordosicae (artemisiae herba), Fructus Anisi Stellati, Mentha arvensis L. syn.M.haplocalyxBrig (menthae pipertiae folium), Rosehips (rosae pseudofructus), and their mixture.Herbaceous plant is described in greater detail in Herbal Drugs andPhytopharmaceuticals; A Handbook for Practice on a ScientificBasis, CRC Press, Stuttgart, Germany, 1994.
Compositions of the present invention can also comprise one or more sweeting agents, and this sweeting agent can be a polyhydric alcohol mentioned above extraly.Suitable sweeting agent comprises natural and synthetical, water miscible, water-insoluble and intense sweetness agent.Sweeting agent can be starch, aspartame, glucide and the hydrogenant starch hydrolysate of dextrose, sucrose, maltose, dextrin, exsiccant Nulomoline, mannose, xylose, ribose, glucose, fructose, levulose, galactose, corn syrup, high-fructose corn syrup, corn syrup solids, partial hydrolysis, or their mixture.Natural or synthetical intense sweetness agent is as also can be used as based on dipeptides, monellin, West Africa Rhizoma Marantae arundinaceae and the L-aspartyl L-phenyl methyl lactamine of intense sweetness agent and dissolved saccharin salt in sweetener packets is contained in.The amount of sweeting agent changes with the sweeting agent of selecting and the sweet amount of expectation.Being used in the sweeting agent in this compositions and the consumption of flavoring agent, can randomly be about 0.005% to about 5% by the weight of described compositions.
Preparation method
Compositions of the present invention can be according to any preparation of several different methods well known in the art.As embodiment, polysaccharide component can be as United States Patent (USP) 6,287,609 described or following method preparations:
Step 1. is suspended in not ground psyllium (" Semen Plantaginis ") in the aqueous alkali that contains Reducing agent of dilution.
If step 2. is used in advance not disinfectant psyllium, just alkali dissolution and the undissolved material of alkali are carried out disinfection with any method known in the art such as pasteurization, radiation, electron beam or pulsed light.
Step 3. is for example centrifugal with any method known in the art, filter, extrude or precipitate except that the undissolved material of lixiviating.
Step 4. adds acid, and it is about 4.5 to about 6.5 that this solution is acidified to pH, obtains the acid gel material, i.e. the gelation polysaccharide.
Step 5. adds desiccant by high shear mixing makes the dehydration of acid gel material, separates this gelatinous mass then from desiccant/water solution.
Step 6. is squeezed into mean diameter greater than 250 microns individual particle with this acid gel material.
Step 7. fluid bed drying acid gel material makes compressible acid gel material become powder morphology.
Before initial alkaline solubilization step, the used raw material of psyllium fractional distillation can or can not grind or physics change or refining.United States Patent (USP) 6,287,609 propose should handle psyllium, make that like this it is scutellate before alkali dissolution, easily heavy-gravity polysaccharide are separated from the insoluble fiber of psyllium.Yet when ground psyllium joined in the alkali mixture, caking and agglomeration took place in ground psyllium.As initial raw material, avoided the caking and the agglomeration of Semen Plantaginis raw material when mixing with the psyllium of not grinding, still do not influenced the effectiveness of alkaline solubilization step with aqueous slkali.As the fractional distillation raw material, obtain the gelation polysaccharide that expanding volume increases with the psyllium of not grinding.The expanding volume of acid gel material be per 0.5 gram xerogel polysaccharide greater than about 40 milliliters, per in one embodiment 0.5 gram xerogel polysaccharide is greater than about 50 milliliters.The percent yield of acid gel material is at least about 75%, in one embodiment at least about 80%.Psyllium of the present invention can be sterilized before handling and also can not sterilized.Before alkali dissolution, psyllium can be sterilized or not sterilize.If use the Semen Plantaginis of undressed (not sterilization) in the fractional distillation process, in fractional distillation process, increase sterilisation step, and can carry out as described below.
(step 1) is known to the alkali dissolution of psyllium.Typically, initial alkali dissolution process is used and is concentrated highly basic, and does not have Reducing agent.Consider the part degraded of polysaccharide chain in the abominable of this processing and the gelation fraction, shown that if desired the aqueous slkali and appropriate reductant such as the boron hydride that use to concentrate still less probably can be more suitable for the gelation fraction that further fractionated form obtains psyllium.Although can use the aqueous slkali up to about 4N, the concentration of alkali is at least about 0.1N and is not more than about 1.0N in the alkali dissolution; In one embodiment at least about 0.1N and be not more than about 0.5N; In another embodiment at least about 0.1N and be not more than about 0.3N.All standard base (SB)s can be used in the alkaline extraction, include but not limited to sodium hydroxide, potassium hydroxide, Lithium hydrate, ammonium hydroxide and Tetramethylammonium hydroxide.About 0.1 gram psyllium to about 400ml aqueous slkali adds about 4 gram psyllium to the suitable ratio of psyllium and aqueous slkali for about 400ml (milliliter) aqueous slkali adds.Alkali dissolution should carry out under about 9 to about 12 pH.
Chemical reducing agent such as boron hydride should be joined in the alkaline solubilization step, so that the depolymerisation minimum of base catalysis.The boron hydride that is suitable for this step includes, but not limited to lithium borohydride, potassium borohydride and sodium cyanoborohydride.In one embodiment, Reducing agent is a sodium borohydride.The valid density of Reducing agent is extremely about 10g/L of about 50mg/L, and about in one embodiment 100mg/L is to about 4g/L, and about in another embodiment 500mg/L is to about 2g/L, and about in another embodiment 800mg/L is to about 1.2g/L.
The dissolved time can change to about 24 hours scope at about 15 minutes, and about in one embodiment 30 minutes to about 180 minutes, to obtain optimum efficiency.Similarly, the dissolving step temperature of carrying out can change to about 40 ℃ scope at about 5 ℃.In one embodiment, dissolution time is about 60 minutes to about 120 minutes under the room temperature.Alkali dissolution can randomly carry out in blanket of nitrogen, to prevent oxidation.
When before psyllium is mixed with aqueous slkali, not sterilizing, need sterilisation step, step 2.If the psyllium of not grinding before the alkaline solubilization step is sterilized as steam disinfection with any method known in the art, this sterilisation step is unnecessary so.Sterilization is meant the growth of inactivation, destruction, elimination and inhibition microorganism.In one embodiment, these microorganisms are morbific material.Alkali dissolution and the not sterilization of solvent fraction of alkali that can use any method known in the art to make up.For example, pasteurization, radiation, electron beam and pulsed light are the acceptable method that sterilization alkali dissolution and alkali do not dissolve fraction mixture.In one embodiment, mixture is by pasteurization.Pasteurization needs heating blends to proper temperature a period of time to sterilize, and can not change the chemical composition of mixture on any degree.Pasteurization can carry out about 30 seconds to about 120 seconds to about 120 ℃ temperature at about 90 ℃.
In fractionated step 3, the undissolved material of alkali is separated from the material of alkali dissolution.This available for example centrifugal finishing of any separation method that does not change insoluble matter substantially known in the art.Skilled in the art will recognize that how to adjust centrifugation time and centrifugal force, be applicable to different centrifuge rotors, plant material and aqueous slkali so that separate.It is known in the art finishing this isolating other method, and may be more suitable for large-scale production gelation polysaccharide, for example precipitates, filters and push.Can be randomly, undissolved material can further clean with aqueous slkali and separate, to make great efforts to improve the yield of alkaline soluble material.
In the step of directly handling 4, it is about 4.5 to about 6.5, about in one embodiment 5 to about 6 that the material of alkali dissolution is acidified to pH, to obtain the acid gel material, i.e. and gelation polysaccharide.Be suitable for acidifying acid and include but not limited to acetic acid, hydrochloric acid, sulphuric acid, oxalic acid, trichloroacetic acid and trifluoroacetic acid.Acidifying persistent period and temperature can change.Although time and temperature can change, acidify was suitable at room temperature carrying out about 2 hours.
Can be randomly, it may be suitable carrying out second extraction in the fractional distillation process stage.If desired, acid dissolvedly can separate with any method known in the art with the acid gel fraction, for example centrifugal, precipitation, gelling etc.In addition, can adopt water, buffer or other suitable solvent optionally washing to improve separation efficiency.Can use this second extraction to send the more gelation polysaccharide of purification, but also may cause some gelation polysaccharide degradation and loss.Be found to be and obtained that expanding volume increases and suitable gelation polysaccharide that gelation rate reduces, multiple extraction step there is no need.
Then in the step 5 of fractional distillation process, from acid gel polysaccharide fraction, remove excessive water.Any method known in the art can be used for the gelatinous mass dehydration.In one embodiment, gelatinous mass may be by dewatering with solvent such as ethanol, acetone, methanol or isopropyl alcohol drying.Can under high shear mixing, add solvent.With any method known in the art gelatinous mass is separated from solvent/water mixture then.Dry with simplification for convenience, the solid concentration of gelatinous mass should be at least about 50%, and in one embodiment, solid concentration is at least about 75%, and the solid concentration of gelatinous mass is about 80% in another embodiment.
Gelatinous mass can carry out drying as lyophilizing, fluid bed drying or vacuum tray seasoning with any method known in the art.In one embodiment, use the fluid bed drying of spawn.Gelatinous mass is extruded the formation small grain-like particles, places on the fluid bed dryer then.Fluid bed dryer can be assembled into cyclonic airflow is provided, help like this to prevent that granule from sticking together and make grain fluidized.The particle suspending of extruding in air column up to the solid concentration that is dried at least about 85%.In the dry run, gelatinous mass should remain below about 75 ℃ temperature.Solid concentration before the preferred gelatinous mass fluid bed drying is greater than about 20%.If necessary, before fluid bed drying, can prior exsiccant gelatinous mass be joined in the gelatinous mass of low solid content by mixing, so that solid concentration increases to greater than about 20%.Be not bound by theory, it is believed that the fluid bed drying technology can obtain the wherein gelation polysaccharide component of individual particle maintenance Nidus Vespae shape.The Nidus Vespae shape helps to be convenient to the gelation polysaccharide powder is pressed into solid dosage forms, especially uses direct compression process.
Method of the present invention
Compositions of the present invention can be used for treating gastroenteropathy.These preparations can use separately or be used in combination with other active substance, are used for the treatment of constipation and hypocatharsis and are used to make intestinal function normal.Compositions of the present invention also can effectively provide more being emptied completely of intestinal, thereby reaches the effect of toxin expelling.In addition, said composition can be used for reducing people's serum cholesterol and control of diabetes people's blood sugar content, and can use separately or use jointly with other active substance.Therefore, the present invention relates to provide the method for following beneficial effect, this beneficial effect be selected from make intestinal function normal, induce hypocatharsis, dietary fiber is provided, reduces serum cholesterol content and their combination, this method is included in when needing this beneficial effect to administration compositions mentioned above.Preferred mammal comprises the people, and companion animals is such as domestic cat, Canis familiaris L., horse, cow, or the like.
Term used herein is for special compositions " using ", and being meant provides compositions to mammal (comprising oneself), and/or instructs, indicates or advise using said composition for any purpose (preferably, for beneficial effect as herein described).When one or more the present composition or the administration of cover box is instructed, is indicated or when advising, this guidance can and/or be informed user for indication, uses said composition that one or more beneficial effects as herein described can and/or will be provided.This indication or the non-limiting example of informing are illustrated as the part description that the present invention overlaps box at this paper.
The administration of being instructed (for example can comprise for example oral indication, by from for example doctor, the professional medical-care personnel, sell professional or tissue and/or radio or television media (promptly, advertisement) verbal assistance) or written guidance (for example, by from for example doctor or other professional medical-care personnel's written instruction (as, prescription), sale professional or tissue (as, by for example selling brochure, pamphlet or other illustrative adnexa), written medium (as, the Internet, Email or other media relevant with computer) and/or with compositions relevant packing (as, comprise and label on the packing of compositions)).Term used herein " written " comprises by words, photo, symbol, and/or other visible descriptors.This indication needn't utilize herein the actual words that uses, but use words, photo, symbol is identical with reception and registration or analog similar meaning is deemed to be within the scope of the present invention.
Oral is preferred.As embodiment, the single administration of the present composition can comprise the polysaccharide component of about 100mg to about 5000mg, and about in one embodiment 1000mg is to the polysaccharide component of about 1500mg.
The administration frequency without limits.Yet, compositions of the present invention typically with few time or principle administration as required, or can be weekly, every day or with more frequent or more not frequent principle with conventional more mode administration.For example, compositions can every day at least once or alternatively every day at least two to three times, with dinner or administration between meal.Frequent administration every day about 1 of compositions is to about 3 times.
Should be appreciated that these descriptions only are used for the purpose of example, can regulate administration according to multiple factor.Desiring the concrete dosage of administration component and the persistent period of treatment is to be mutually related.Dosage and therapeutic scheme also depend on following factor: used concrete compositions, the indication of treatment, the effect of compositions, mammiferous personal attributes (such as, for example mammiferous body weight, age, sex and physical state), to the compliance of therapeutic scheme, or the like.
Compositions of the present invention is particularly useful for mixing with liquid, aqueous before administration.In fact, the present inventor has developed into the invention of this paper and has made aqueous solution or dispersion to be delivered to consumer easily and effectively.Similarly, method of the present invention comprises and liquid, aqueous mixing such as water or fruit juice (for example, fruice or vegetable juice).Can use any liquid, aqueously, and often decide by the hobby of consumer.Comprising liquid, aqueous compositions will typically comprise, for example, at least about 20% this is liquid, aqueous, or about 40% to about 99.9%, or about 60% to about 98%, or about 70% to about 96% this is liquid, aqueous, wherein said percentage ratio is all by the weight of described compositions.
Embodiments of the invention
Below be the embodiment of component of the present invention, compositions and method.Use conventional method or method preferably as herein described to prepare compositions.Providing embodiment is in order to demonstrate the invention, rather than limits its scope by any way.
Embodiment 1
Can be used for polysaccharide component of the present invention by following preparation.Undressed, not ground psyllium (2 gram) stirred in blanket of nitrogen 90 minutes in room temperature with the 0.2N sodium hydroxide (400 milliliters) that contains sodium borohydride (400 milligrams).The pH value of solution is 10 to 11.Solution passed through pasteurizer 50 seconds under 100 ℃ temperature.Behind the pasteurization, mixture is with 23, centrifugal 20 minutes of 500xg.Decant supernatant in the not solvent fraction that from centrifuge bottle, is precipitated out.Solvent fraction does not mix with fresh sodium hydroxide/sodium borohydride solution (100 milliliters), and then the centrifugal 15 minutes yields with the raising solvent fraction.Add the pH to 5.5 that acetic acid is regulated supernatant by stirring under the room temperature, form gel.Add isopropyl alcohol with high shear mixing and make the gel dehydration.Then aqueous isopropanol is toppled over from gel.The solids content of gel is 30%.Make gel by extruder and be extruded into individual particle.The granule of extruding enters the fluidized bed dryer that cyclonic airflow screen cloth such as Conidur screen cloth are housed.Air themperature remains on 80 ℃.Gelling temp remains below 70 ℃ in the dry run.With the particle drying powdered, and to be ground to average particle size distribution be about 80 microns, and the yield with about 85% obtains final polysaccharide component.
Embodiment 2
Preparation with shown in amount comprise the compositions of indicating component:
| Component | Amount (percentage by weight) |
| Polysaccharide component, average particle size distribution are about 100 microns | 27.1 |
| Maltodextrin | 15.6 |
| Citric acid | 2 |
| N LITE LP (starch, the city is sold by National Starch and Chemical, Bridgewater, NJ) | 34.1 |
| TEXTRA PLUS (starch, the city is sold by National Starch and Chemical, Bridgewater, NJ) | 20.2 |
| Flavouring agent, coloring agent, sweeting agent | 1 |
Embodiment 3
Preparation with shown in amount comprise the compositions of indicating component:
| Component | Amount (percentage by weight) |
| Polysaccharide component, average particle size distribution are about 50 microns | 27.5 |
| Maltodextrin | 16 |
| Citric acid | 2.3 |
| N LITE LP (starch, the city is sold by National Starch and Chemical, Bridgewater, NJ) | 35 |
| TEXTRA PLUS (starch, the city is sold by National Starch and Chemical, Bridgewater, NJ) | 15 |
| Thorn kidney bean glue | 1.6 |
| Flavouring agent, coloring agent, sweeting agent | 2.6 |
Embodiment 4
Preparation with shown in amount comprise the compositions of indicating component:
| Component | Amount (percentage by weight) |
| Polysaccharide component, average particle size distribution are about 120 microns | 28.5 |
| Maltodextrin | 13 |
| Citric acid | 2.5 |
| N LITE LP (starch, the city is sold by National Starch and Chemical, Bridgewater, NJ) | 35.5 |
| TEXTRA PLUS (starch, the city is sold by National Starch and Chemical, Bridgewater, NJ) | 15.4 |
| Guar gum | 2.2 |
| Flavouring agent, coloring agent, sweeting agent | 2.9 |
Embodiment 5
Preparation with shown in amount comprise the compositions of indicating component:
| Component | Amount (percentage by weight) |
| Polysaccharide component, average particle size distribution are about 120 microns | 33.76 |
| Maltodextrin | 33.76 |
| Ultra-Sperse2000 | 20.25 |
| Thorn kidney bean glue | 2.70 |
| Aspartame | 0.49 |
| Acesulfame potassium | 0.49 |
| Citric acid | 4.44 |
| Flavouring agent, coloring agent, sweeting agent | 4.11 |
Embodiment 6
Preparation with shown in amount comprise the another kind of compositions of indicating component:
| Component | Amount (percentage by weight) |
| Polysaccharide component, average particle size distribution are about 120 microns | 37.28 |
| Maltodextrin | 37.28 |
| Ultra-Sperse 2000 | 14.91 |
| Thorn kidney bean glue | 0.54 |
| Aspartame | 0.54 |
| Acesulfame potassium | 0.54 |
| Citric acid | 4.90 |
| Flavouring agent, coloring agent, sweeting agent | 4.01 |
Embodiment 7
Preparation with shown in amount comprise the another kind of compositions of indicating component:
| Composition | Amount (percentage by weight) |
| Polysaccharide component, average particle size distribution are about 120 microns | 33.66 |
| Maltodextrin | 33.66 |
| Ultra-Sperse 2000 | 20.19 |
| Thorn kidney bean glue | 2.69 |
| Aspartame | 0.46 |
| Acesulfame potassium | 0.46 |
| Citric acid | 3.82 |
| Flavouring agent, coloring agent, sweeting agent | 5.06 |
In each embodiment 2,3,4,5,6 and 7, polysaccharide component is with described herein consistent.As an embodiment, polysaccharide component comprises as United States Patent (USP) 6,287, the fraction B described in 609.As another embodiment, polysaccharide component comprises as United States Patent (USP) 6,287, fraction B described in 609 and C.As another embodiment, polysaccharide component contains any, any combination or whole following component with the content of indication:
| Component | The content that is present in polysaccharide component by the weight of described polysaccharide component |
| Xylose | About 55% to about 70% |
| Arabinose | About 15% to about 20% |
| Rhamnose | 0% to about 5% |
| Mannose | 0 to about 0.5% |
| Galactose | About 1% to about 2% |
| Glucose | 0% to about 0.5% |
| Alduronic acid | About 0.5% to about 50% |
In each embodiment 2,3,4,5,6 or 7, can form the agglomerate that comprises polysaccharide component, maltodextrin and citric acid.It is about 200 microns that agglomerate is ground to average particle size distribution.With agglomerate and starch, natural gum (when existing), flavouring agent, coloring agent and sweeting agent dry blend.
Embodiment 8
According to each prepares the compositions of about 9.5 grams in embodiment 2,3 or 4, obtain the single dose of compositions.Compositions is dispersed in about 240 milliliters water or orange juice.Once a day compositions is given to make the normal people of intestinal function.Similar compositions is needed to reduce the people of serum cholesterol content twice every day.
Claims (59)
1. compositions that comprises a plurality of polyoses grains, wherein said polyoses grain comprises the polysaccharide component that contains xylose and arabinose, the ratio of wherein described by weight xylose and described arabinose is at least about 3: 1, and wherein said polyoses grain have about 0.001 micron to about 150 microns average particle size distribution.
2. compositions as claimed in claim 1, described compositions comprise the polysaccharide component by the weight of described compositions about 10% to about 90%.
3. compositions as claimed in claim 1, described compositions comprise the polysaccharide component by the weight of compositions about 20% to about 50%.
4. compositions as claimed in claim 1, described compositions comprise the polysaccharide component by the weight of compositions about 30% to about 70%.
5. compositions as claimed in claim 1, the ratio of wherein said xylose and described arabinose are about 3: 1 to about 6: 1 by weight.
6. compositions as claimed in claim 5, wherein said polyoses grain also comprise the component that is selected from galactose, glucose, alduronic acid and their mixture.
7. compositions as claimed in claim 6, the average particle size distribution of wherein said polyoses grain are about 0.1 micron to about 125 microns.
8. compositions as claimed in claim 7, the average particle size distribution of wherein said polyoses grain are about 1 micron to about 100 microns.
9. compositions as claimed in claim 6, the ratio of wherein said xylose and described arabinose are about 3: 1 to about 5: 1 by weight.
10. compositions as claimed in claim 9, described compositions also comprises starch, wherein said polyoses grain be different on physical property to the described starch of small part.
11. compositions as claimed in claim 10, described compositions comprise the starch by the weight of described compositions about 10% to about 90%.
12. compositions as claimed in claim 9, described compositions also comprises natural gum, wherein said polyoses grain be different on physical property to the described natural gum of small part.
13. compositions as claimed in claim 12, described compositions comprise the natural gum by the weight of described compositions about 0.001% to about 10%.
14. compositions as claimed in claim 13, wherein at least a natural gum are selected from thorn kidney bean glue and guar gum.
15. compositions as claimed in claim 1, described compositions also comprises a plurality of agglomerates, and wherein said agglomerate comprises described polyoses grain and dispersed component, and described dispersed component is selected from binding agent, suspending agent, edible acid and their mixture.
16. compositions as claimed in claim 15, wherein said agglomerate have about 100 microns to about 500 microns average particle size distribution.
17. compositions as claimed in claim 16, the ratio of wherein said xylose and described arabinose are about 3: 1 to about 6: 1 by weight.
18. compositions as claimed in claim 17, wherein said polyoses grain also comprise the component that is selected from galactose, glucose, alduronic acid and their mixture.
19. compositions as claimed in claim 18, the average particle size distribution of wherein said agglomerate are about 100 microns to about 400 microns.
20. compositions as claimed in claim 19, described compositions also comprise the component that is selected from lubricant, emulsifying agent, surfactant, cellulosic material and their mixture.
21. compositions as claimed in claim 18, the ratio of wherein said xylose and described arabinose are about 3: 1 to about 5: 1 by weight.
22. compositions as claimed in claim 21, described compositions also comprises starch, wherein said agglomerate be different on physical property to the described starch of small part.
23. compositions as claimed in claim 22, described compositions comprise the starch by the weight of described compositions about 10% to about 90%.
24. compositions as claimed in claim 21, described compositions also comprises natural gum, wherein said agglomerate be different on physical property to the described natural gum of small part.
25. compositions as claimed in claim 24, described compositions comprise the natural gum by the weight of described compositions about 0.001% to about 10%.
26. compositions as claimed in claim 25, wherein at least a natural gum are selected from thorn kidney bean glue and guar gum.
27. compositions as claimed in claim 18, wherein said agglomerate comprise the binding agent by the weight of described agglomerate about 10% to about 90%.
28. compositions as claimed in claim 27, wherein said binding agent comprises maltodextrin.
29. compositions as claimed in claim 28, wherein said agglomerate comprise xylose and arabinose by the weight of described agglomerate about 20% to about 80%.
30. compositions as claimed in claim 29, wherein said agglomerate comprise the binding agent by the weight of described agglomerate about 10% to about 60%.
31. compositions as claimed in claim 30, wherein said agglomerate comprise the binding agent by the xylose of the weight of described agglomerate about 30% to about 70% and arabinose and about 20% to about 50%.
32. compositions as claimed in claim 27, wherein said agglomerate also comprises edible acid.
33. compositions as claimed in claim 32, wherein at least a edible acid is selected from lactic acid, citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid and succinic acid.
34. compositions as claimed in claim 33, wherein said agglomerate comprise the edible acid by the weight of described agglomerate about 0.001% to about 8%.
35. compositions as claimed in claim 34, wherein at least a edible acid is a citric acid.
36. compositions as claimed in claim 27, described compositions also comprises starch, wherein said agglomerate be different on physical property to the described starch of small part.
37. compositions as claimed in claim 36, described compositions comprise the starch by the weight of described compositions about 10% to about 90%.
38. compositions as claimed in claim 27, described compositions also comprises natural gum, wherein said agglomerate be different on physical property to the described natural gum of small part.
39. compositions as claimed in claim 38, described compositions comprise the natural gum by the weight of described compositions about 0.001% to about 10%.
40. compositions that comprises a plurality of agglomerates, wherein said agglomerate comprises the polysaccharide component that contains xylose and arabinose, the ratio of wherein described by weight xylose and described arabinose is at least about 3: 1, and wherein said agglomerate have about 100 microns to about 500 microns average particle size distribution.
41. compositions as claimed in claim 40, wherein said agglomerate also comprises dispersed component, and described dispersed component is selected from binding agent, suspending agent, edible acid and their mixture.
42. compositions as claimed in claim 41, wherein said agglomerate also comprise the component that is selected from galactose, glucose, alduronic acid and their mixture.
43. compositions as claimed in claim 42, the average particle size distribution of wherein said agglomerate are about 100 microns to about 400 microns.
44. compositions as claimed in claim 43, the average particle size distribution of wherein said polyoses grain are about 125 microns to about 350 microns.
45. compositions as claimed in claim 41, the ratio of wherein said xylose and described arabinose are about 3: 1 to about 6: 1 by weight.
46. compositions as claimed in claim 45, described compositions also comprises starch, wherein said agglomerate be different on physical property to the described starch of small part.
47. compositions as claimed in claim 48, described compositions comprise the starch by the weight of described compositions about 10% to about 90%.
48. compositions as claimed in claim 47, described compositions also comprises natural gum, wherein said agglomerate be different on physical property to the described natural gum of small part.
49. compositions as claimed in claim 48, described compositions comprise the natural gum by the weight of described compositions about 0.001% to about 10%.
50. compositions as claimed in claim 48, wherein at least a natural gum are selected from thorn kidney bean glue and guar gum.
51. compositions as claimed in claim 47, wherein said agglomerate comprise the binding agent by the weight of described agglomerate about 10% to about 90%.
52. compositions as claimed in claim 51, wherein said binding agent comprises maltodextrin.
53. compositions as claimed in claim 52, wherein said agglomerate comprise xylose and arabinose by the weight of described agglomerate about 20% to about 80%.
54. compositions as claimed in claim 53, wherein said agglomerate comprise the binding agent by the weight of described agglomerate about 10% to about 60%.
55. compositions as claimed in claim 54, wherein said agglomerate comprise the binding agent by the xylose of the weight of described agglomerate about 30% to about 70% and arabinose and about 20% to about 50%.
56. compositions as claimed in claim 53, wherein said agglomerate also comprises edible acid.
57. compositions as claimed in claim 56, wherein at least a edible acid is selected from lactic acid, citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid and succinic acid.
58. compositions as claimed in claim 57, wherein said agglomerate comprise the edible acid by the weight of described agglomerate about 0.001% to about 8%.
59. compositions as claimed in claim 58, wherein at least a edible acid is a citric acid.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36851403A | 2003-02-18 | 2003-02-18 | |
| US10/368,510 | 2003-02-18 | ||
| US10/368,514 | 2003-02-18 | ||
| US10/369,039 | 2003-02-18 | ||
| US10/633,970 | 2003-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1747716A true CN1747716A (en) | 2006-03-15 |
Family
ID=36166929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200480003720 Pending CN1747717A (en) | 2003-02-18 | 2004-02-18 | Compositions comprising a polysaccharide component and one or more coating layers. |
| CN 200480003711 Pending CN1747716A (en) | 2003-02-18 | 2004-02-18 | Compositions comprising a plurality of particles or agglomerates having a defined particle size |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200480003720 Pending CN1747717A (en) | 2003-02-18 | 2004-02-18 | Compositions comprising a polysaccharide component and one or more coating layers. |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN1747717A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107279454A (en) * | 2017-06-20 | 2017-10-24 | 上海交通大学 | A kind of new viscous food compositions and preparation method thereof |
-
2004
- 2004-02-18 CN CN 200480003720 patent/CN1747717A/en active Pending
- 2004-02-18 CN CN 200480003711 patent/CN1747716A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107279454A (en) * | 2017-06-20 | 2017-10-24 | 上海交通大学 | A kind of new viscous food compositions and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1747717A (en) | 2006-03-15 |
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