CN1733774A - Rosuvastain calcium intermediate preparation method - Google Patents
Rosuvastain calcium intermediate preparation method Download PDFInfo
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- CN1733774A CN1733774A CN 200510044287 CN200510044287A CN1733774A CN 1733774 A CN1733774 A CN 1733774A CN 200510044287 CN200510044287 CN 200510044287 CN 200510044287 A CN200510044287 A CN 200510044287A CN 1733774 A CN1733774 A CN 1733774A
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Abstract
The invention discloses a process for preparing the key intermediate of rosuvastatin calcium, which is [7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidine-5-yl]-(3R)-3-(trialkyl-silyloxy)-5-oxy-(E)-6-enanthate] mandelic acid benzyl ester.
Description
Technical field
The present invention relates to prepare the key intermediate of rosuvastain calcium---general formula is the I{ chemical name: (E)-7-[4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methylsulfonyl amino) pyrimidine-5-yl]-(3R)-3-(trialkyl silica base)-5-oxygen-6-enanthic acid the amygdalic acid benzyl ester the new chemical process of compound.
I (wherein, P=TBDMS, TBDPS, TMS, TES, TIPS etc.)
Background technology
European patent application EP 0521471 disclose rosuvastain calcium chemistry is by name: (E)-7-[4-(4-fluorophenyl)-6-sec.-propyl-2-[methyl (methylsulfonyl) amino] pyrimidine-5-yl]-(3R; 5S)-3,5-dihydroxy heptyl-6-olefin(e) acid calcium salt } (shown in the structure See Figure).
Rosuvastain calcium is a HMG CoA reductase inhibitor.EP 0521471 discloses rosuvastain calcium and has obtained by [7-[4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methylsulfonyl amino) pyrimidine-5-yl]-(3R)-3-hydroxyl-5-oxygen-(E)-reduction of heptenoic acid methyl esters and processing subsequently.Yet rosuvastain calcium can then be sloughed protecting group with acid by the compound of reduction general formula I, and then is converted into free acid or calcium salt and obtains.
Summary of the invention
The invention provides by general formula is the preparation technology of the compound of I, and the present invention can prepare the compound that general formula is I with higher yield, milder reaction conditions.
General formula of the present invention is that the preparation method of the compound of I comprises the steps:
A, (3R)-3-(trialkyl silica base) pentanedioic acid list Benzyl Amygdalate II prepares (3R)-3-(trialkyl silica base)-5-oxygen-6-triphenylphosphine enanthic acid amygdalic acid benzyl ester III;
B, III and aldehyde IV{ chemistry is by name: [4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methylsulfonyl amino) pyrimidine-5-yl] formaldehyde } coupling obtains I;
Above-mentioned reaction scheme is:
Step a of the present invention is to be feedstock production (3R)-3-(trialkyl silica base)-5-oxygen-6-triphenylphosphine enanthic acid amygdalic acid benzyl ester III with (3R)-3-(trialkyl silica base) pentanedioic acid list Benzyl Amygdalate II;
II under the condition that triethylamine exists with methyl-chloroformate generation condensation reaction, condenses without purification, is directly used in next step after extracting, concentrating;
In certain temperature, certain solvent, methyl triphenyl phosphorus bromide reacts with above-mentioned enriched material under the highly basic effect, obtains condenses III crude product.The solvent that is adopted in this reaction is ethers or aromatic solvent or its mixture, for example: tetrahydrofuran (THF), glycol dimethyl ether and toluene, or its mixture; The highly basic that is adopted in this reaction is metal alkylide, metal hydride, amido metal, MAGNESIUM METAL compound.For example: n-Butyl Lithium (n-BuLi), isobutyl-lithium (s-BuLi), tert-butyl lithium (t-BuLi), sodium hydride (NaH), two (TMS) potassium amide (KHMDS), two (TMS) Lithamide (LiHMDS), two (TMS) sodium amide (NaHMDS), di-isopropyl magnesium bromide (i-Pr
2MgBr); Originally be reflected under-80 ℃～50 ℃ the temperature and carry out.
Step b is that III and aldehyde IV coupling obtain I in certain temperature, certain solvent.The solvent that is adopted in this reaction is ethers or aromatic solvent or its mixture, for example: tetrahydrofuran (THF), ether, acetonitrile, glycol dimethyl ether and toluene, or its mixture; Originally be reflected under 0 ℃～120 ℃ the temperature and carry out.
Advantage of the present invention is: the use I of (1) initiative is as key intermediate synthesizing rosuvastatin spit of fland calcium; (2) existing in of the amygdalic acid among the I improved the optical purity of the asymmetric reduction product of ketone among the I in a way effectively; (3) the inventive method with use corresponding phosphate dialkyl ester to make raw material or use oxidation phenylbenzene [4-(4-fluorophenyl)-6-sec.-propyl-2-[methyl (methylsulfonyl) amino] pyrimidine-5-ylmethyl] phosphine make raw material method relatively, obvious improved products productive rate and quality are provided.
Embodiment
Further elaborate preparation method of the present invention below by embodiment.
1, (3R)-3-(tertiary butyl dimethyl Si base)-5-oxygen-6-triphenylphosphine enanthic acid amygdalic acid benzyl ester bromide is the preparation (P=TBDMS) of IIIa:
Under-20 ℃, to 3-[(tertiary butyl dimethylsilyl) the oxygen base] add triethylamine (15mL) in toluene (500mL) solution of pentanedioic acid Benzyl Amygdalate IIa (48.6g), under-20 ℃, in mixture, add methyl-chloroformate (15mL), after adding, naturally be warmed up to room temperature, at room temperature stirred two hours, add sodium bicarbonate (100g) and water (100mL), saturated sodium-chloride water solution (100mL) washing, organic phase is dissolved in the 200mL anhydrous tetrahydro furan standby after concentrating.
In the dry there-necked flask of 1L, add anhydrous tetrahydro furan 300mL, add methyl triphenyl phosphorus bromine (71g) then, under nitrogen protection, cool to 0 ℃ of n-BuLi (120mL) that drips 1.6M, stirred then 30 minutes;-25 ℃ add above-mentioned tetrahydrofuran solution down, and temperature control-25 ℃ reaction is warmed up to room temperature after 3 hours, adds entry (120.0mL), saturated sodium bicarbonate (120.0ml), collects organic phase, add saturated sodium-chloride water solution (120.0mL) washing, organic phase concentrates and obtains IIIa (35g).
2, (E)-7-[4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methylsulfonyl amino) pyrimidine-5-yl]-(3R)-and 3-(tertiary butyl dimethyl Si base)-5-oxygen-6-enanthic acid] the amygdalic acid benzyl ester is the preparation (P=TBDMS) of Ia:
Add IIIa (74.3g), IV (35.8g) in acetonitrile (50mL), oil bath reflux 6 hours is with the reaction mixture underpressure distillation, obtain the deep yellow thick liquid, with recrystallization from ethyl acetate/petroleum ether obtain yellow solid Ia (85g, purity: 98%, HPLC).
Owing to described the present invention according to its special embodiment, some modification and equivalent variations are conspicuous and comprise within the scope of the invention for the those of ordinary skill in this field.
Claims (6)
1. one kind prepares rosuvastain calcium key intermediate [7-[4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methylsulfonyl amino) pyrimidine-5-yl]-(3R)-3-(trialkyl silica base)-5-oxygen-(E)-6-enanthic acid] method of amygdalic acid benzyl ester (general formula is I).It is characterized in that this method may further comprise the steps:
A, (3R)-3-(trialkyl silica base) pentanedioic acid list Benzyl Amygdalate II prepares (3R)-3-(trialkyl silica base)-5-oxygen-6-triphenylphosphine enanthic acid amygdalic acid benzyl ester III;
B, III and aldehyde IV{ chemistry is by name: [4-(4-fluorophenyl)-6-sec.-propyl-2-(N-methyl-N-methylsulfonyl amino) pyrimidine-5-yl] formaldehyde } coupling obtains I.
2. the method for claim 1, wherein the highly basic that adopts of step a is metal alkylide, metal hydride, amido metal, MAGNESIUM METAL compound; For example: n-Butyl Lithium, isobutyl-lithium, tert-butyl lithium, sodium hydride, two (TMS) potassium amide, two (TMS) Lithamide, two (TMS) sodium amide, di-isopropyl magnesium bromide.
3. as the described method of claim 1～2, wherein the solvent of step a employing is ethers or aromatic solvent or its mixture; For example: tetrahydrofuran (THF) (THF), glycol dimethyl ether and toluene, or its mixture.
4. as the described method of claim 1～3, wherein step a carries out under-80 ℃～50 ℃ temperature.
5. the method for claim 1, wherein the solvent that adopts of step b is ethers or aromatic solvent or its mixture, for example: tetrahydrofuran (THF) (THF), ether, acetonitrile, glycol dimethyl ether and toluene, or its mixture.
6. the method for claim 1, wherein step b carries out under 0 ℃～120 ℃ temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100442879A CN100352821C (en) | 2005-08-22 | 2005-08-22 | Rosuvastain calcium intermediate preparation method |
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| CNB2005100442879A CN100352821C (en) | 2005-08-22 | 2005-08-22 | Rosuvastain calcium intermediate preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7868169B2 (en) | 2005-08-16 | 2011-01-11 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin intermediate |
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| JP2648897B2 (en) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | Pyrimidine derivatives |
| GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7868169B2 (en) | 2005-08-16 | 2011-01-11 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin intermediate |
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Application publication date: 20060215 Assignee: Lunan Beite Pharmaceutical Co., Ltd. Assignor: Lunan Pharmaceutical Group Co., Ltd. Contract record no.: 2013370000261 Denomination of invention: Method for preparing rosuvastatin calcium intermediate Granted publication date: 20071205 License type: Exclusive License Record date: 20131210 |
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Inventor after: Zhang Guimin Inventor after: Zhang Lixing Inventor after: Wang Benli Inventor after: Zhao Zhiquan Inventor after: Peng Lizeng Inventor after: Di Fumin Inventor before: Zhao Zhiquan Inventor before: Peng Lizeng Inventor before: Di Fumin |
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