CN1730017A - Mighty soft capsule of gastrodia tuber and eucommia and its preparation process - Google Patents
Mighty soft capsule of gastrodia tuber and eucommia and its preparation process Download PDFInfo
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- CN1730017A CN1730017A CN 200410070200 CN200410070200A CN1730017A CN 1730017 A CN1730017 A CN 1730017A CN 200410070200 CN200410070200 CN 200410070200 CN 200410070200 A CN200410070200 A CN 200410070200A CN 1730017 A CN1730017 A CN 1730017A
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Abstract
The invention relates to a capsule of rhizoma Gastrodiae and gutta-percha and its preparing process, the capsule comprises contents and capsule material, wherein the contents basically comprises compound active component, dispersing agent and suspending agent by the weight ratio of 1:0.5-2:0.0005-0.1. The contents can also comprise compound active component, deflocculating agent, suspension auxiliary agent and wetting agent by the weight ratio of 1:0.5-2:0.01:0.001-0.1. The capsule material mainly comprise gelatin, plasticizing agent and water by the weight ratio of 1:0.1-1:0.5-2.
Description
Technical field
The present invention relates to powerful gastrodia tuber eucommia soft capsule of a kind of powerful gastrodia elata-cortex capsule novel form and preparation technology thereof.
Background technology
Rhizoma Gastrodiae endogenous wind stopping removing obstruction in the collateral to relieve pain in the powerful gastrodia tuber eucommia side, Cortex Eucommiae liver and kidney tonifying, strong muscles and bones is a principal agent with this two medicine; Be aided with Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis expelling wind and dampness, easing joint movement looses and goes up purgation rheumatism all over the body; The kind neck and head pain of controlling of Rhizoma Ligustici wind-expelling pain-stopping strengthens the power that whole body removes the rheumatism the meridian dredging; Radix Angelicae Sinensis is gentle hot fragrant, and blood-activating and qi-promoting dispels the wind except that the stasis of blood, with Rhizoma Et Radix Notopterygii, the Radix Angelicae Pubescentis dispelling the wind and dampness pathogens arthralgia pain of pulling together; Radix Aconiti Kusnezoffii, the hot cold expelling of Radix Aconiti Lateralis Preparata, the expelling wind and dampness pain relieving, the former is good at analgesia, and latter's cold expelling power is strong, the kind disease of controlling all chronic diseaseses, two medicines strengthen the merit of whole body dispersing cold for relieving pain; Herba Visci, Radix Achyranthis Bidentatae help Cortex Eucommiae invigorating the liver and kidney, and bone and muscle strengthening helps Radix Angelicae Sinensis dissipating blood stasis blood and helps Rhizoma Gastrodiae, notopterygium wind dispelling collateral dredging; Heat clearing away YIN nourishing again a little less than Radix Scrophulariae, Radix Rehmanniae kidney tonifying benefit waist knee joint wither, anti-hot product impairment of YIN.The medicine of respectively distinguishing the flavor of in the powerful gastrodia elata-cortex capsule share, and plays the wind that looses altogether and invigorates blood circulation the effect of muscles and tendons relaxing to alleviate pain.Be used for wind-induced ache tendon and vessel, numb limbs and tense tendons, walking disorder, waist and leg ache, headache and dizziness etc.
Based on above-mentioned classics recipe, the domestic dosage form of having developed listing has three kinds of hard capsule, tablet and pills.Powerful gastrodia elata-cortex capsule records in " Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation " the 4th WS
3-B-0854-91, prescription:
The Rhizoma Gastrodiae 69.6g Cortex Eucommiae (processed with salt) 73.9g Radix Aconiti Kusnezoffii Preparata 8.7g Radix Aconiti Lateralis Preparata (system) 8.7g
Radix Angelicae Pubescentis 43.4g Rhizoma Ligustici 51.3g Radix Scrophulariae 51.3g Radix Angelicae Sinensis 87g
Radix Rehmanniae 139.1g Radix Cyathulae 51.3g Herba Visci 51.3g Rhizoma Et Radix Notopterygii 87g
Method for making: above 12 flavors, Rhizoma Gastrodiae powder is broken into fine powder, and Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, seven flavors such as the medicinal residues and the Cortex Eucommiae, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into cream, with above-mentioned powder, mixes, drying is pulverized, and sieves, and makes granule, drying sprays into volatile oil, mixing, incapsulate, make 1000, promptly.
Modern pharmacology and clinical research prove that powerful gastrodia elata-cortex capsule has the cardiovascular and cerebrovascular vessel of adjusting tension force, and total peripheral resistance is descended, decreased heart rate, and ejection time prolongs, and blood flow increases, and myocardial oxygen consumption reduces.The cerebral blood flow increasing amount produces the maincenter depression effect, and analgesic activity is arranged.The adjustable ring nucleotide metabolism reduces electroencephalogram α wave index and appearance sleep ripple, has sedative-hypnotic property.To hypophysis--adrenal cortex function has excitation.Oozing out with swelling of multiple inflammation all there is inhibitory action, and promotes the stable of immunologic function and cell membrane, tool antiinflammatory action.Treatment total effective rate to post-traumatic brain syndrome is 92.3%, is 87.5% to the treatment total effective rate of treatment wind-phlegm blood stasis type cerebral infarction, is 85% to the treatment total effective rate of the resistive apoplexy of the wind-phlegm stasis of blood.Also have clinical summary to report in addition, this medicine is to cerebral arteriosclerosis, hypertension, angioneurotic headache, neurasthenic treatment effective percentage is all more than 92%, to treating various joint diseases, waist, cervical spondylosis, total effective rate are 82.8%, to the treatment senile osteoporosis, promote that the knitting total effective rate is 85.1%.Along with the development of Chinese medicine modern study, we are not difficult also to find that the hard capsule sealing is poor, and the volatile ingredient in the medical materials such as Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii is easy to scatter and disappear, and causes the effective dose instability, influences problems such as its clinical efficacy.
Summary of the invention
The objective of the invention is on powerful gastrodia elata-cortex capsule prescription and preparation method basis, to use the soft capsule technology, a kind of powerful gastrodia tuber eucommia novel form soft capsule and preparation technology thereof are provided.
That soft capsule preparation is used for more is water-insoluble, to photaesthesia, run into damp and hot instability, the volatile medicine of oxidation easily, to strengthen stability of drug, the effect of cover the adverse drug taste in addition in addition, being convenient to take experimental results show that the bioavailability of soft capsule is higher than hard capsule and conventional tablet.Contain the volatile oil component of Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii four Chinese medicine material in the gastrodia elata-cortex capsule, as be made into soft capsule then can suppress effectively the to volatilize dissipation of wet goods composition, overcome the effective dose instability, improve its clinical effectiveness.Because these characteristics of soft capsule have determined that medicine is hedged off from the outer world in the shell, its face shaping, disintegration time and stability etc., none is the influence of receptaculum material and content component not.
In the powerful gastrodia elata-cortex capsule prescription, contain 12 kinds of medical materials, Rhizoma Gastrodiae powder is broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, seven flavor medicine material decoctings such as medicinal residues and the Cortex Eucommiae boil into extractum, and the active component complexity uses single solvent to be difficult to make the content component to form stabilising system, soft capsule molding and quality all there are severe bad influence, also can't determine to be fit to the capsule material of content.Therefore realize that the key of the object of the invention is the stable homogeneity problem that solves soft capsule content, Chinese crude drug extract for the active component complexity, often consider to make content form stable suspension, find by a large amount of experiments, when using water-soluble base or oil-soluble substrate as dispersant, the content prescription has significant difference, but two kinds of prescriptions can both satisfy the soft capsule quality requirement, is described in detail with regard to two kinds of different prescriptions of content below.
The active component of the powerful gastrodia tuber eucommia soft capsule content of the present invention is with the powerful gastrodia elata-cortex capsule of " Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation preparation " the 4th WS3-B-0854-91, handle by 12 flavor medical materials and method in the prescription, (1) Rhizoma Gastrodiae powder is broken into fine powder.(2) Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil.(3) seven flavors such as the medicinal residues and the Cortex Eucommiae decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and filtrate is condensed into cream, mixes with above-mentioned powder (1), and drying is pulverized, and sieves.(2) and (3) be all active component of the present invention.
Powerful gastrodia tuber eucommia soft capsule is made up of capsule material and content among the present invention, and content is made up of active component and water soluble dispersing agent, suspending agent substantially, and their weight ratio is 1: 0.5～2: 0.0005～0.1.
Water soluble dispersing agent is for being selected from Polyethylene Glycol-200 (PEG-200), Polyethylene Glycol-300 (PEG-300), Polyethylene Glycol-400 (PEG-400) or Polyethylene Glycol-600 (PEG-600) in the content.Because the compound active composition in the content is a pressed powder, is insoluble to oil or other solvents, it should be made into suspension and incapsulate.In the suspension of soft capsule if medicine is suspended in the oleaginous base, though its also can disperse under one's belt, because of each granule is surrounded the stripping that influences medicine by oleaginous base; If with medicine be suspended in the miscible substrate of water in, then disperse rapidly under one's belt, form very big absorbing surface.Active component is slightly soluble in PEG400 or Polyethylene Glycol-600, as the dispersant of content, is characterized in that it has good bioavailability, can obtain good blood drug level by its soft capsule of making, and medicine is absorbed better.Also because Polyethylene Glycol or Polyethylene Glycol-600 should not oxidation under common environment, become sour, being easy to the intestines and stomach liquid mixes, dissolving medicine wherein more effectively is released and absorbs, particularly low-molecular-weight as PEG400 or Polyethylene Glycol-600 is most of after gastrointestinal absorption is discharged by original shape in the urine.Though can mixing with water, PEG400 or Polyethylene Glycol-600 concerning softgel shell, there is no dissolution.
Suspending agent is ethylene glycol-10000, Polyethylene Glycol-8000, Polyethylene Glycol-4000 (PEG-4000) or Polyethylene Glycol-6000 (PEG-6000) in the content.Because the compound active composition in the content is slightly soluble in dispersant, for guaranteeing the bioavailability of powerful gastrodia tuber eucommia soft capsule, by a large amount of experimental selection a kind of toxicity less, can either be dissolved in the dispersant, can well powerful gastrodia tuber eucommia medicated powder be suspended in the dispersant again, and can for a long time stable material, Polyethylene Glycol-4000 or polyethylene glycol 6000 become ideal suspending agent.
In the soft capsule content except that necessary medicine active component and dispersant, suspending agent, can also add stabilizing agent is propylene glycol or glycerol, the weight ratio of compound active composition and stabilizing agent is 1: 0.005～1, make the softgel shell sclerosis in order to prevent PEG400 from absorbing the moisture in the softgel shell, in content, add propylene glycol or glycerol, be that moisture between scalable content and the softgel shell is bidirectional balanced, and have certain antisepsis.
Because active component is made up of powder and volatile oil, wherein contain 1～2 ‰ volatile oil approximately, when the application water soluble dispersing agent prepares the content of soft capsule, utilized PEG-400 to have certain oil loving characteristics, can with volatile oil earlier with the part dispersant after, with the residue dispersant, help and revolve agent and medicated powder mixes, the mistake colloid mill, get soft capsule content, conventional method is pressed into soft capsule.
In soft capsule content, except that using water soluble dispersing agent, also often use oil-soluble dispersant, so content of the present invention is made up of active component and oil-soluble dispersant, suspending agent, wetting agent, their weight ratio is 1: 0.5～2: 0.01～1: 0.001～0.1.
Oil-soluble dispersant is selected from all kinds of vegetable oil, as one or more the mixture in Oleum Sesami, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Oleum Glycines, almond oil, peach kernel oil, Oleum Gossypii semen, Oleum Helianthi, olive oil, rapeseed oil, Petiolus Trachycarpi oil or the Oleum Cocois.
When using vegetable oil, usually suspending agent is selected from the solid matter that can increase dispersant viscosity, is respectively in Carboxymethyl cellulose sodium, hydroxyethyl-cellulose, hyprolose, hydroxypropyl emthylcellulose, methylcellulose, ethyl cellulose, hydroxyethylmethyl-cellulose, carbomer, polyvinyl alcohol, sodium alginate, chitin, chitose, agar, Cera Flava, oily wax mixture, xanthan gum, arabic gum or the casein one or more.They can effectively solve the lamination of content, improve the content flowability, are easy to suppress soft capsule.
Wetting agent can be surfactant-based material, be selected from Tweens (polysorbas20,40,60,65,80,85), spans (span 20,80,85) or poloxamer 188, they can increase the absorption and raising bioavailability of effective ingredient, also can increase the flowability of content, the DL better effects if of more single use suspending agent.
Form by powder and volatile oil owing to active component as described above, wherein contain 1～2 ‰ volatile oil approximately, after so application oil-soluble disperse medium can be dissolved in vegetable oil with volatile oil earlier when preparing soft capsule content, with the residue dispersant, help and revolve agent, wetting agent and medicated powder thereof and mix, cross colloid mill, get soft capsule content, conventional method is pressed into soft capsule.
No matter dispersant is water miscible or oil-soluble, no matter content component also involved in the present invention how, but their capsule material is made up of gelatin, plasticizer and water substantially, three's weight ratio is 1: 0.1～1: 0.5～2, plasticizer is selected from glycerol, sorbitol, hexanetriol, propylene carbonate, hexanediol, anhydro sorbitol oxolane alcohol ether, diethylene glycol monoethyl ether, 1,3-dimethyl-2-imidazolone or the different sorbate of dimethyl.Effect for preventing that softgel shell from going mouldy is beneficial to long-term storage, also can add antiseptic, and the weight ratio of gelatin and antiseptic is 1: 0.003, and antiseptic can be benzoic acid, sodium benzoate, Methyl p-hydroxybenzoate, ethyl hydroxybenzoate, propylparaben.
Powerful gastrodia tuber eucommia soft capsule can adopt conventional soft capsule preparation technology to make among the present invention, as manual die pressing, rotating mould platen press or dropping preparation method.Usually select the rotation pressing for use, use rotation rolling capsule machine automatically, temperature is controlled at 25～35 ℃, rolling soft capsule.
The powerful gastrodia tuber eucommia soft capsule of the present invention significant advantage of having compared with other dosage forms, overcome the defective that existing dosage form exists, poor as sealing, volatile ingredients such as Radix Angelicae Pubescentis are easy to scatter and disappear, the effective dose instability, clinical effectiveness difference etc., guaranteed making full use of of effective ingredient, disintegration is short, absorbs fast in the body, the bioavailability height, and meet detection requirement under the relevant soft capsule item of Chinese Pharmacopoeia.More what deserves to be explained is when using PEG-400 or PEG-600 in the water soluble dispersing agent, because of they have water absorption, the water that softgel shell itself is contained often can shift to content rapidly, thereby the elasticity of softgel shell is reduced, influence the disintegrate of soft capsule, stability etc., therefore content quality requires high, if but select for use oil-soluble dispersant such as plant wet goods not only can with volatilization such as Radix Angelicae Pubescentis oiliness composition arbitrarily than dissolving mutually, improved uniformity of sample, but also having overcome the effect (promptly weakened the migration of between softgel shell and content moisture) of softgel shell to content, the cost of raw material also can reduce significantly.
Below be gastrodia tuber eucommia soft capsule segmental stability data of the present invention.
Table 1 gastrodia tuber eucommia soft capsule stability test
| Disintegration (in the pharmacopeia regulation 60 minutes) | 12 minutes | 14 minutes | 16 minutes | 19 minutes | 23 minutes | 26 minutes | 30 minutes | |
| Assay | Gastrodine (, should be not less than the 0.24mg/ grain) in gastrodine | 0.30 | 0.30 | 0.29 | 0.28 | 0.26 | 0.27 | 0.26 |
The specific embodiment
When using water soluble dispersing agent, the powerful gastrodia tuber eucommia soft capsule of the present invention preferred contents component is active component, PEG400, Polyethylene Glycol-6000, propylene glycol, weight ratio preferred 1: 1: 0.02～0.05: 0.05～0.1.
When using oil-soluble dispersant, the powerful gastrodia tuber eucommia soft capsule of the present invention preferred contents component is active component, vegetable oil, oily wax mixture, sorbester p17, preferred 1: 0.9: 0.25 of weight ratio: 0.008～0.012 oily wax mixture is made up of hydrogenated vegetable oil, Cera Flava, Oleum Cocois, and three's ratio is 1: 1: 3.
The capsule material is made up of gelatin, plasticizer and water substantially among the present invention, the plasticizer preferably glycerine, and gelatin, glycerol, water preferred weight ratio are 1: 0.33～0.35: 0.9, the preferred methyl hydroxybenzoate of antiseptic.
The following examples will be described the present invention in more detail.
Embodiment one, powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: get the Rhizoma Gastrodiae 69.6g Cortex Eucommiae (processed with salt) 73.9g Radix Aconiti Kusnezoffii Preparata 8.7g Radix Aconiti Lateralis Preparata (system) 8.7g Radix Angelicae Pubescentis 43.4g Rhizoma Ligustici 51.3g Radix Scrophulariae 51.3g Radix Angelicae Sinensis 87g Radix Rehmanniae 139.1g Radix Cyathulae 51.3g Herba Visci 51.3g Rhizoma Et Radix Notopterygii 87g, more than 12 the flavor, Rhizoma Gastrodiae powder is broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil 0.2 gram, seven flavors such as the medicinal residues and the Cortex Eucommiae, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is condensed into cream, with above-mentioned powder, mix, drying is pulverized, and sieves.Be total to such an extent that active component (medicated powder and volatile oil) about 200 restrains.
2, preparation content:
Volatile oil 0.2 gram is mixed with 50gPEG-400, stir evenly; Other gets PEG-400 150 grams, PEG-4000 4 grams and propylene glycol 20 grams, is heated to 65 ℃ and makes fusing, stirs evenly, as water-soluble base; Mix with the mixture of PEG-400 with above-mentioned medicated powder and volatile oil again, stir evenly.
3, preparation capsule material: get gelatin 5000 grams, water 4500 grams, be heated to 70 ℃, get glycerol 1750 grams, methyl hydroxybenzoate 15 grams, stir, evacuation 1 hour mixes with above-mentioned gelatin, 70 ℃ of insulation standing over night.
4, compacting soft capsule: with the capsule material liquid that makes and the content rotation rolling capsule machine automatically of packing into, temperature is controlled at 25～35 ℃ and suppresses the soft capsule that every ball contains active component 200mg.
Embodiment two, powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: with embodiment one
2, preparation content:
Volatile oil 0.2 gram is mixed with 50gPEG-400, stir evenly; Other gets PEG-400 50 grams, PEG-6000 0.1 gram and propylene glycol 1 gram, and method is with embodiment one.
3, preparation capsule material: get gelatin 5000 grams, water 2500 grams, be heated to 70 ℃, get glycerol 500 grams, stir, evacuation 1 hour mixes with above-mentioned gelatin, 70 ℃ of insulation standing over night.
4, compacting soft capsule: with embodiment one.
Embodiment three: powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: with embodiment one.
2, preparation content:
Volatile oil 0.2 gram is mixed with 50gPEG-400, stir evenly; PEG-400 350 grams, PEG-4000 20 grams and propylene glycol 200 grams, method is with embodiment one.
3, preparation capsule material: get gelatin 5000 grams, water 10000 grams, be heated to 70 ℃, get glycerol 5000 grams, stir, evacuation 1 hour mixes with above-mentioned gelatin, 70 ℃ of insulation standing over night.
4, compacting soft capsule: with embodiment one.
Embodiment four, powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: with embodiment one.
2, preparation content: volatile oil 0.2 gram is mixed with 50gPEG-400, stir evenly; Other gets PEG-400 150 grams, PEG-4000 4 grams, is heated to 65 ℃ and makes fusing, stirs evenly, as water-soluble base; Mix with medicated powder again, stir evenly.
3, preparation capsule material: with embodiment one.
4, compacting soft capsule: with embodiment one.
Embodiment five, powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: with embodiment one
2, preparation content: get Cera Flava 200 grams, Oleum Cocois 600 grams, hydrogenated vegetable oil 200 grams, be heated to 80 ℃ and make fusing, stirring evenly and putting cold-working is suspending agent.
Volatile oil 0.2 gram is mixed with 100g Oleum Glycines, stir evenly; Other gets Oleum Glycines 80 grams, suspending agent 50 grams, and sorbester p17 2 grams are heated to 60 ℃ and make fusing, stir evenly, as oil-soluble substrate; Mix with the mixed liquor of Oleum Glycines with above-mentioned medicated powder and volatile oil again, stir evenly.
3, preparation capsule material: with embodiment one.
4, compacting soft capsule: with embodiment one.
Embodiment six, powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: with embodiment one.
2, preparation content:
Volatile oil 0.2 gram is mixed with 50g Oleum Glycines, stir evenly; Other gets Semen Maydis oil 50 grams, suspending agent 2 grams, and sorbester p17 0.2 gram is heated to 60 ℃ and makes fusing, stirs evenly, as oil-soluble substrate; Mix with the mixed liquor of Oleum Glycines with above-mentioned medicated powder and volatile oil again, stir evenly.
3, preparation capsule material: with embodiment one.
4, compacting soft capsule: with embodiment one.
Embodiment seven, powerful gastrodia tuber eucommia preparation of soft capsule
1, preparation active component: with embodiment one.
2, preparation content:
Volatile oil 0.2g is mixed with 100g Oleum Glycines, stir evenly; Oleum Arachidis hypogaeae semen 300 grams, suspending agent 200 grams, sorbester p17 20 grams are heated to 60 ℃ and make fusing, stir evenly, as oil-soluble substrate; Mix with the mixed liquor of Oleum Glycines with above-mentioned medicated powder and volatile oil again, stir evenly.
3, preparation capsule material: with embodiment one.
4, compacting soft capsule: with embodiment one.
Claims (12)
1, a kind of powerful gastrodia tuber eucommia soft capsule, it is made up of capsule material and content, it is characterized in that content is made up of active component and water soluble dispersing agent, suspending agent substantially, and their weight ratio is 1: 0.5～2: 0.0005～0.1.
2, described according to claim 1, it is characterized in that containing in the content stabilizing agent, the weight ratio of active component and stabilizing agent is 1: 0.005～1.
3, described according to claim 1 or 2, it is characterized in that water soluble dispersing agent is for being selected from Polyethylene Glycol-200, Polyethylene Glycol-300, Polyethylene Glycol-400 or Polyethylene Glycol-600.
4, described according to claim 1 or 2, it is characterized in that suspending agent is selected from Polyethylene Glycol-10000, Polyethylene Glycol-8000, Polyethylene Glycol-4000 or Polyethylene Glycol-6000.
5, described according to claim 2, it is characterized in that stabilizing agent is selected from propylene glycol or glycerol.
6, a kind of powerful gastrodia tuber eucommia preparation of soft capsule method, when it is characterized in that using water soluble dispersing agent and preparing the content of soft capsule, can be with after volatile oil and the part dispersant, with the residue dispersant, help and revolve agent and medicated powder mixes, cross colloid mill, get soft capsule content, conventional method is pressed into soft capsule.
7, a kind of powerful gastrodia tuber eucommia soft capsule, it is made up of capsule material and content, it is characterized in that content is made up of active component and oil-soluble dispersant, suspending agent, wetting agent, and their weight ratio is 1: 0.5～2: 0.01～1: 0.001～0.1.
8, described according to claim 7, it is characterized in that oil-soluble dispersant is selected from all kinds of vegetable oil, as one or more the mixture in Oleum Sesami, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Oleum Glycines, almond oil, peach kernel oil, Oleum Gossypii semen, Oleum Helianthi, olive oil, rapeseed oil, Petiolus Trachycarpi oil, the Oleum Cocois.
9, described according to claim 7, it is characterized in that suspending agent is selected from one or more in Carboxymethyl cellulose sodium, hydroxyethyl-cellulose, hyprolose, hydroxypropyl emthylcellulose, methylcellulose, ethyl cellulose, hydroxyethylmethyl-cellulose, carbomer, polyvinyl alcohol, sodium alginate, chitin, chitose, agar, Cera Flava, oily wax mixture, xanthan gum, arabic gum, the casein.
10, described according to claim 7, it is characterized in that wetting agent is selected from Tweens 20, polysorbate40, polysorbate60, polysorbate65, Tween 80, polysorbate85, span 20, sorbester p17, sorbester p37, poloxamer 188.
11, a kind of powerful gastrodia tuber eucommia preparation of soft capsule method, when it is characterized in that using the oil-soluble disperse medium and preparing soft capsule content, after volatile oil can being dissolved in vegetable oil, with the residue dispersant, help and revolve agent, wetting agent and medicated powder thereof and mix, cross colloid mill, get soft capsule content, conventional method is pressed into soft capsule.
12, according to claim 1,2 or 7 described, it is characterized in that their capsule material is made up of gelatin, plasticizer and water substantially, three's weight ratio is 1: 0.1～1: 0.5～2.11, described according to claim 10, it is characterized in that plasticizer is selected from glycerol, sorbitol, hexanetriol, propylene carbonate, hexanediol, anhydro sorbitol oxolane alcohol ether, diethylene glycol monoethyl ether, 1,3-dimethyl-2-imidazolone or the different sorbate of dimethyl.
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| CN 200410070200 CN1730017A (en) | 2004-08-06 | 2004-08-06 | Mighty soft capsule of gastrodia tuber and eucommia and its preparation process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101314000B (en) * | 2008-06-27 | 2013-01-23 | 陶国闻 | Gastrodia tuber eucommia health care capsule and preparation method thereof |
| CN102920768A (en) * | 2012-10-12 | 2013-02-13 | 河南科技大学 | Cortex eucommiae capsule and preparation method thereof |
| CN105403629A (en) * | 2015-09-09 | 2016-03-16 | 贵州医科大学 | Characteristic map detection method of powerful gastrodia elata-eucommia ulmoides capsules |
| CN106266635A (en) * | 2016-09-24 | 2017-01-04 | 四川金堂海纳生物医药技术研究所 | A kind of treat in the Chinese medicine composition and preparation method thereof of wind-induced numb limbs and tense tendons |
-
2004
- 2004-08-06 CN CN 200410070200 patent/CN1730017A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101314000B (en) * | 2008-06-27 | 2013-01-23 | 陶国闻 | Gastrodia tuber eucommia health care capsule and preparation method thereof |
| CN102920768A (en) * | 2012-10-12 | 2013-02-13 | 河南科技大学 | Cortex eucommiae capsule and preparation method thereof |
| CN105403629A (en) * | 2015-09-09 | 2016-03-16 | 贵州医科大学 | Characteristic map detection method of powerful gastrodia elata-eucommia ulmoides capsules |
| CN106266635A (en) * | 2016-09-24 | 2017-01-04 | 四川金堂海纳生物医药技术研究所 | A kind of treat in the Chinese medicine composition and preparation method thereof of wind-induced numb limbs and tense tendons |
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