CN1706368A - Mouse steriliant and its prepn process - Google Patents

Abstract

The chemical male mouse sterilant consists of cyclopropanol derivative 3-chloro-1.2-diol as effective component in 0.5-1 wt% and granular bait in 99-99.5 wt%. The bait consists of corn powder, wheat flour, bran, fish meal, sugar and vegetable oil in certain proportion. The mouse sterilant can kill spermatogenous cell and supporting cell of male mouse to reach the aim of being sterile. It has no damage to interstitial cell of male mouse and thus has double effect of controlling propagation and 'competitive propagation interference'. Once application of the mouse sterilant can control the mouse density below no-harm level for at least 15 months. It has no sensitivity and toxicity on farm animal and birds and no environmental pollution, and may be used widely in household, farm land, forest, grass land and other places.

Description

Rodents sterilant and preparation method thereof

Affiliated technical field

Do not invent and relate to a kind of rodents sterilant, particularly male rodents sterilant is a kind of chemical derivative, belongs to chemosterilants.

Background technology

Chemical rodenticide as far back as B.C. just on the books, is killed muroid with arsenide.Nineteen fifties anticoagulation rodenticide appearance indicates the major progress of chemical prevention, and at agricultural produce, protection against rodents is protected a forest, the protection grassland, and aspects such as Mus biography disease control have all produced positive effect.But the back low-density level that kills mouse is held time the longest only about 1 year, later on Mus density rises gradually and recovers and surpass previous level, the control of harmful animal is normally with the way that increases colony's mortality rate, and by reducing the breeding potential of colony, the realization population density reduces, be the new way of harmful animal control, early have the pest control of applied chemistry apholate to obtain the example of significant results.Big more by the mortality rate of rule animal population, its breeding potential and survival rate are also high more, understanding theoretically, and reducing breeding potential, that the control of population quantity is increased mortality rate is more effective.Above-mentioned chemical rodenticide toxicity is bigger, brings problems such as secondary pollution.

Summary of the invention

Purpose of the present invention overcomes the deficiency of above-mentioned chemical rodenticide existence, and a kind of male muroid chemosterilants is provided, and reduces reproduction rate, makes the muroid density of infection be in low-level state, and longer duration is pollution-free, nuisanceless.

The technical scheme that the technology of the present invention problem solves is, a kind of male chemosterilants that is used to control the plague of rats, and halo propanediol derivative, 3-chloro-1.2-glycol, its molecular formula is As former medicine, account for 0.5～1%; Account for 99.5～99% with bait formulation and make graininess, the Damxung Mus eats enough amounts, then reaches sterile degree.The bait of bait formulation and proportioning are Semen Maydis powder 10～20%; Flour 10～20%; Wheat bran 40～60%; Fish flour 10～20%; Sugar 1～5%; Vegetable oil 1%.

Preparation processing:

1. stir: with proportioning is 0.5～1% the former medicine of 3-chloro-1.2-glycol chemosterilants, with proportioning be 99.5～99% bait formulation, put into blender, stir.In blender, inject suitable moisture, marginal not water, stir on the limit.

2. molding: enter make-up machine again and be shaped to graininess.

3. baking: the graininess apholate after the molding, enter baking oven, toast, oven temperature is at 70 ℃～90 ℃, and stoving time is 1～2 hour.

4. sieve: the male rodents sterilant of graininess of making 3 * 5mm after sieving.

The invention has the beneficial effects as follows:

1, this medicament can kill and wound male Mus spermatogonium, and sustenticular cell makes spermatid break off source of nutrition and can not develop into sperm, reaches sterile purpose.

2, this medicament does not have injury to male Mus Interstitial cell, so do not influence sex hormones secretion, this medicine not only has the control effect of general rat-bane, still the dual function of tool " competitive breeding is disturbed ".

3, a dispenser can be controlled at Mus density and not endanger below horizontal being at least 15 months, thereby the control cycle of the plague of rats is prolonged, and becomes annually or 3 years secondaries by 1 year twice, has saved great amount of manpower and material resources.

4, this medicament all has sterile effect to the main home mouse of China and farmland mouse-Rattus norvegicus, grassland bandicoot-apodemus chevrieri, black abdomen chinchilla.

5, this pharmacy security is reliable, and to poultry, domestic animal, birds are not had sensitivity, do not poison.Pollution-free, nuisanceless, compliance with environmental protection requirements.

The specific embodiment

Below with reference to embodiment, the description detailed in addition to the present invention:

The main component of male rodents sterilant is, a kind of male chemosterilants in order to the control plague of rats, and halo propanediol derivative, 3-chloro-1.2-glycol, its molecular formula is

Be a kind of moderately toxic chemosterilants, as former medicine, proportioning is 0.5～1%, with the bait formulation proportioning be 99.5～99%, make the graininess apholate, edible for male Mus, edible when it to enough amounts, can be sterile, experimental results show that 90mg/kg, it is sterile to cause male Mus.The bait of bait formulation and proportioning are: Semen Maydis powder 18%; Flour 18%; Wheat bran 50%; Fish flour 10%; Sugar 2.2%; Vegetable oil 1% with the 3-chloro-1.2-glycol of former medicine 0.8%, mixes post-treatment, and the tool practice of preparation processing is:

1, stir: former medicine of 3-chloro-1.2-glycol with 0.8% and 99.2% bait formulation are put into blender, stir.In blender, inject 15% moisture content, (generally being no more than 20%), marginal not water, stir on the limit.

2, molding: enter make-up machine again and make graininess, 3 * 5mm.

3, baking: the graininess apholate after the molding, enter the baking oven baking, oven temperature is 80 ℃, toasts 1 hour.

4, sieve: mesh is that 3 * 5mm sieve is big mesh sieve, mesh is little mesh sieve less than the sieve of 3 * 5mm, stay on the griddle greater than the granule of 3 * 5mm, granule and powder less than 3 * 5mm, sieve through little mesh, wherein 3 * 5mm apholate the granule on little mesh sieve is certified products, all the other substandard product, put together reshaping, repeat second, third, to make specification again be 3 * 5mm graininess apholate to the 4th step.

The male-sterilant experiment causes sterile result: press under the effect of 90mg/kg dosage, the pathology section examination result of administration male testis after 25 days shows the obvious pathological changes of generation, tried male Mus spermatogonium, spermatocyte, sustenticular cell damage shrinkage deformation, even formation cavity, these cells almost disappear, and reach sterile effect.Another experimental result shows, the Interstitial cell not damaged so do not influence sex hormones secretion, still has sexual behaviour, still has competitiveness in colony, plays " competitive breeding is disturbed " effect.

The domestic birds and animals experiment, respectively 4 of cat, Canis familiaris L., chickens are pressed the 80mg/kg administration, and after 30 days, its testicular weight, contorted seminiferous tubules, spermatogonium, spermatocyte, spermatid, result of the test show no abnormal, confirm nonhazardous, do not have sterile effect.

The apholate palatability testing proves that palatability is good.

Forest zone main harm Mus population is apodemus chevrieri and black abdomen chinchilla, and medication is the contorted seminiferous tubules atrophy after 30 days, and spermatogonium, spermatocyte, spermatid reduce, and confirms that apholate also has the fertility of inhibition effect to forest zone Mus kind.

Claims (2)

1, a kind of rodents sterilant is used to control the male chemosterilants of the plague of rats, it is characterized in that: halo propanediol derivative, and 3-chloro-1.2-glycol, its molecular formula is As former medicine, account for 0.5～1%; Account for 99.5～99% with bait formulation, make the graininess male-sterilant, the bait of bait formulation and proportioning are: Semen Maydis powder 10～20%; Flour 10～20%; Wheat bran 40～60%; Fish flour 10～20%; Sugar 1～5%; Vegetable oil 1%.

2, by the preparation method of the described male chemosterilants of claim 1, it is characterized in that:

1. stir: with proportioning is 0.5～1% the former medicine of 3-chloro-1.2-glycol chemosterilants, with proportioning be 99.5～99% bait formulation, put into blender, stir.In blender, inject suitable water, marginal not water, stir on the limit.

2. molding: the apholate that stirs enters make-up machine and makes 3 * 5mm graininess.

3. baking: the graininess apholate after the molding enters baking oven, toasts, and oven temperature is at 70 ℃～90 ℃, and stoving time is 1～2 hour.

4. sieve: make the male rodents sterilant of 3 * 5mm graininess after sieving.