CN1682983A - Medicinal composition containing wild jujube seed, lucid ganoderma and ginseng leaf and its preparing process and use - Google Patents
Medicinal composition containing wild jujube seed, lucid ganoderma and ginseng leaf and its preparing process and use Download PDFInfo
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- CN1682983A CN1682983A CN 200510008709 CN200510008709A CN1682983A CN 1682983 A CN1682983 A CN 1682983A CN 200510008709 CN200510008709 CN 200510008709 CN 200510008709 A CN200510008709 A CN 200510008709A CN 1682983 A CN1682983 A CN 1682983A
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Abstract
The present invention discloses a kind of medicine composition containing wild jujube seed, glossy ganoderma and ginseng leaf and its preparation process and application. The present invention features that the medicine composition consists of extracts from Chinese medicinal materials including wild jujube seed, glossy ganoderma and ginseng leaf and medicinal supplementary material. The medicine composition is prepared into different oral preparations, including tablet, capsule, granule and soft capsule. Pharmaceutical experiment results show that the medicine composition of the present invention has even high pharmaceutical effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of contain Semen Ziziphi Spinosae, Ganoderma, Folium Ginseng pharmaceutical composition and preparation and application.
Background technology
Determining of Chinese medicine compound is on the basis of analyzing pathogenesis, determines method of treatment, method of treatment guidance under form the prescription meet state of an illness needs, prescription is made up of medicine, but it is not the rabble that arbitrarily uses Chinese medicine, but be foundation with the method for treatment, select appropriate drug, appropriate drug dosage, under instruction of Chinese Medicine theory, combine, method of treatment is the theoretical foundation of prescription, and prescription is the imbody of method of treatment, therefore, prescription is a method of treatment, and method of treatment is a prescription, and the two is indivisible.
Semen Ziziphi Spinosae, Semen Ziziphi Spinosae, this product is the dry mature seed of Rhamnaceae zizyphus short, bristly hair or beard thing Ziziphi Spinosae, main product in Hebei, ground such as Shaanxi, Liaoning, Henan, Shandong, another name Semen Ziziphi Spinosae, Fructus Choerospondiatis core, jujube nucleus, the master contains two kinds of triterpenoids: betulin (Betulin), betulic acid (BetulicAcid), other contains Semen Ziziphi Spinosae Saponin (Jujuboside), jujubogenin (Jujubogenin), fatty oil, protein, sitosterol, vitamin C etc., nature and flavor with return through: sweet, sour, flat.Go into the heart, spleen, liver, gallbladder meridian, main effect be calm the nerves, nourish heart, arresting sweating, have the central nervous system of inhibition to present calmness, syngignoscism through test; Folium Ginseng is the dried leaves of Araliaceae Radix Ginseng Panaxginseng C.A.Mey., and sweet, the little hardship of property is flat, returns spleen, lung, heart channel, has that strongly invigorating primordial QI, multiple arteries and veins take off admittedly, an invigorating the spleen to benefit the lung, the effect of promoting the production of body fluid, calming the nerves; Ganoderma another name Ganoderma lucidum (Leyss. Ex Fr.) Karst., Ganoderma Lucidum, Ganoderma lucidum seu Japonicum, Ganoderma, Ganoderma is a kind of macro fungi, is the Polyporaceae plant, its exsiccant sporophore is used as medicine, and is traditional tonic, and successive dynasties book on Chinese herbal medicine ancient books and records all have record, studies show that the Ganoderma main component is an ergosterol, fungal lysozyme, mannitol, polypeptide, aminoacid etc., have detoxifcation, protect the liver, heart tonifying, calm, anti-hypoxia, convulsion, many-sided biological activity such as relieving cough and asthma, be used for angina pectoris, atherosclerosis, hyperlipidemia, acute viral hepatitis, the neurasthenia, diseases such as chronic bronchitis.
Consult patent documentation, do not retrieve the pharmaceutical preparation, the health product that carry out the prescription preparation with Semen Ziziphi Spinosae, Ganoderma, Folium Ginseng.
Summary of the invention
For these reasons, the present invention is under Chinese medical theory instructs, in conjunction with the clinical practice experience, carry out prescription with Chinese medicine Semen Ziziphi Spinosae, Folium Ginseng, Ganoderma, carry out the extraction separation purification and obtain extract, add pharmaceutic adjuvant and be prepared into solid preparation, The pharmacological results shows that the present invention respectively organizes preparation and has better pharmacological action.
The object of the invention is to provide a kind of pharmaceutical composition that contains Semen Ziziphi Spinosae, Ganoderma, Folium Ginseng.
The present invention also aims to provide a kind of preparation of pharmaceutical compositions that contains Semen Ziziphi Spinosae, Ganoderma, Folium Ginseng to become the preparation method of tablet, capsule, granule, soft capsule.
The present invention also aims to provide this pharmaceutical composition and preparation thereof hypnotic, improve immunocompetence, central nervous system disease aspect in application.
The present invention is achieved by the following scheme.
One. process recipes
Consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 2-3 weight portion, Ganoderma 1-2 weight portion, Folium Ginseng 1-2 weight portion; Wherein be preferably Semen Ziziphi Spinosae 2.5 weight portions, Ganoderma 1.25 weight portions, Folium Ginseng 1.25 weight portions;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 1-3 time, each 0.5-1 hour, add 8-12 times of water gaging, collecting decoction at every turn, the 100-300 mesh sieve filters, filtrate is condensed into the clear paste that relative density is 1.10-1.20 (80 ℃), adds ethanol after the cooling and is 50%-70%, standing over night to containing the alcohol amount.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.30-1.35 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into tablet with conventional pharmaceutical technology, granule, capsule, soft capsule.
Two. check and analysis
The check and analysis of total saponins:
By " health food check and assessment technique standard " version (health food functional component and sanitary index inspection specification second portion 23) prescriptive procedure check in 2003.
Result: see Table 1:
Active constituent content relatively in table 1 preparation
Total saponin content
Group
％
Tablet 4.61 of the present invention
Capsule 4.72 of the present invention
Granule 4.59 of the present invention
Soft capsule 4.82 of the present invention
Conclusion: show that by above check and analysis experiment technology of the present invention has practical significance.
Three. pharmacology embodiment
Embodiment 1
Influence to mouse sleep time
Laboratory animal: 40 of Kunming kind white mice, body weight 18-22g, male and female half and half.
The experiment medicine: the present invention respectively organizes preparation (Baishilikang Medicine Science and Technology Co., Ltd., Beijing's laboratory provides)
SHUIBAO JIAONANG (Tai Ji group provides)
Experimental technique: get mice, random packet, 10 every group, once a day, successive administration 2d after the last administration, enters the time of sleep with the electroencephalongraph mice, and experimental result sees Table 2:
The different preparations of table 2 are to promoting the influence of mice sleep
The group number of animals enters the time of sleep
Only minute
Normal saline 10 10.23+1.26
SHUIBAO JIAONANG 10 6.35 ± 1.34
*
Tablet 10 4.23 ± 0.95 of the present invention
*[
*]
Capsule 10 4.01 ± 0.89 of the present invention
*[
*]
Granulation machine agent 10 4.14 ± 1.06 of the present invention
*[
*]
Soft capsule 10 4.06 ± 1.12 of the present invention
*[
*]
Annotate: compare with the normal saline group
*P＜0.05,
*P＜0.01; Compare with positive controls [
*] P＜0.05
Embodiment 2
To qi-deficiency type rats'liver tumor inhibition effect
Laboratory animal: rat, 150g～180g, male and female are regardless of.(causing model of qi-asthenia according to document) by herbal pharmacology teaching and research room of Shenyang Pharmaceutical University
The experiment medicine: the present invention respectively organizes preparation (Baishilikang Medicine Science and Technology Co., Ltd., Beijing's laboratory provides)
Astragalus polysaccharides oral liquid (the Shanxi academy of traditional Chinese medicine provides)
Normal saline
Experimental technique: get rat and do inoculation in the liver of W256, inoculate after 7 days, press the dosage intraperitoneal injection of anesthesia of 35mg/kg with pentobarbital sodium, fixing, cutting open the belly exposes liver, and tumor surface maximum diameter (a) and path (b) are pressed (a*b on the measurement liver
2)/2=V (gross tumor volume).Separate stomach, arteria duodenalis, common hepatic artery and proper hepatic artery, the ligation stomach, the arteria duodenalis far-end, with silver brain clip blocking-up common hepatic artery, in sending into proper hepatic artery again at the gastroduodenal artery upper cut and after inserting external diameter 0.3mm conduit under the operating loupe, inject respectively by the experiment grouping then and be subjected to the reagent thing, dosage is 0.3g crude drug/kg, normal saline etc. hold inequality, and postoperative tube drawing ligation gastroduodenal artery is decontroled the common hepatic artery silver brain clip, sew up the incision again, place animal housing to wait to revive rat, continue breeding observing, performed the operation back 8 days, detect gross tumor volume by last method, the results are shown in Table 3:
Table 3 preparation qi-deficiency type of the present invention rats'liver tumor inhibition effect
Gross tumor volume change in volume percent after the administration of group administration pre-neoplastic volume
mm
3 mm
3 ％
Normal saline 4.08 6.12+49.8
Astragalus polysaccharides oral liquid 4.36 3.28-24.8
*
Tablet 4.33 2.51-42.0 of the present invention
*
Capsule 4.43 2.55-42.4 of the present invention
*
Granule 4.38 2.51-42.6 of the present invention
*
Soft capsule 4.51 2.68-40.6 of the present invention
*
Compare with the normal saline group
*P＜0.05,
*P＜0.01
Using the present invention respectively organizes preparation and central nervous system disorders such as anxiety neurosis, depression are carried out pharmacological evaluation the present invention respectively organizes preparation and all have pharmacological action preferably.
Conclusion: show by above pharmacological evaluation, pharmaceutical composition of the present invention and respectively organize preparation to hypnotic, improve immunocompetence, the central nervous system disease aspect all has better pharmacological action, and relatively has better pharmacological action with veriety.
Four. preparation embodiment
Embodiment 1
Consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 2kg, Ganoderma 1kg, Folium Ginseng 1kg;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 1 time, each 0.5 hour, add 8 times of water gagings, collecting decoction at every turn, 100 mesh sieves filter, filtrate is condensed into the clear paste that relative density is 1.10 (80 ℃), and adding ethanol after the cooling is 50% to containing the alcohol amount, standing over night.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.30 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into 1000 in tablet, or 1000 bags of granules, or 1000 of capsules with conventional pharmaceutical technology, or 1000 of soft capsules.
Embodiment 2
Consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 3kg, Ganoderma 2kg, Folium Ginseng 2kg;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 3 times, each 1 hour, add 12 times of water gagings, collecting decoction at every turn, 300 mesh sieves filter, filtrate is condensed into the clear paste that relative density is 1.20 (80 ℃), and adding ethanol after the cooling is 70% to containing the alcohol amount, standing over night.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.35 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into 1000 in tablet, or 1000 bags of granules, or 1000 of capsules with conventional pharmaceutical technology, or 1000 of soft capsules.
Embodiment 3
Consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 2.5kg, Ganoderma 1.25kg, Folium Ginseng 1.25kg;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 2 times, each 1 hour, add 10 times of water gagings, collecting decoction at every turn, 200 mesh sieves filter, filtrate is condensed into the clear paste that relative density is 1.15 (80 ℃), and adding ethanol after the cooling is 60% to containing the alcohol amount, standing over night.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.32 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into 1000 in tablet, or 1000 bags of granules, or 1000 of capsules with conventional pharmaceutical technology, or 1000 of soft capsules.
Embodiment 4
Consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 2.5kg, Ganoderma 1.25kg, Folium Ginseng 1.25kg;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 1 time, each 0.7 hour, add 9 times of water gagings, collecting decoction at every turn, 150 mesh sieves filter, filtrate is condensed into the clear paste that relative density is 1.12 (80 ℃), and adding ethanol after the cooling is 55% to containing the alcohol amount, standing over night.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.31 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into 1000 in tablet, or 1000 bags of granules, or 1000 of capsules with conventional pharmaceutical technology, or 1000 of soft capsules.
Embodiment 5
Consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 2.5kg, Ganoderma 1.25kg, Folium Ginseng 1.25kg;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 3 times, each 0.9 hour, add 11 times of water gagings, collecting decoction at every turn, 250 mesh sieves filter, filtrate is condensed into the clear paste that relative density is 1.18 (80 ℃), and adding ethanol after the cooling is 65% to containing the alcohol amount, standing over night.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.34 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into 1000 in tablet, or 1000 bags of granules, or 1000 of capsules with conventional pharmaceutical technology, or 1000 of soft capsules.
Embodiment 6
Consisting of of crude drug of the present invention: the consisting of of crude drug of the present invention: Semen Ziziphi Spinosae 25kg, Ganoderma 12.5kg, Folium Ginseng 12.5kg;
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 2 times, each 1 hour, add 10 times of water gagings, collecting decoction at every turn, 200 mesh sieves filter, filtrate is condensed into the clear paste that relative density is 1.15 (80 ℃), and adding ethanol after the cooling is 60% to containing the alcohol amount, standing over night.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.32 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into 10000 in tablet, or 10000 bags of granules, or 10000 of capsules with conventional pharmaceutical technology, or 10000 of soft capsules.
Claims (5)
1. a pharmaceutical composition that contains Semen Ziziphi Spinosae, Ganoderma, Folium Ginseng is characterized in that this pharmaceutical composition is by Semen Ziziphi Spinosae 2-3 weight portion, Ganoderma 1-2 weight portion, Folium Ginseng 1-2 weight portion.
2. pharmaceutical composition according to claim 1 is characterized in that this pharmaceutical composition consists of: Semen Ziziphi Spinosae 2.5 weight portions, Ganoderma 1.25 weight portions, Folium Ginseng 1.25 weight portions.
3. pharmaceutical composition according to claim 1, it is characterized in that Semen Ziziphi Spinosae, Ganoderma, Folium Ginseng obtain extract through the extraction purification and be mixed with into tablet, capsule, granule, soft capsule with pharmaceutic adjuvant, the control total saponin content is not less than 4.53%.
4. preparation of drug combination method according to claim 1, its feature may further comprise the steps:
(1) pretreatment of raw material
Semen Ziziphi Spinosae rolls to be left grain, Ganoderma section, Folium Ginseng and not to pulverize;
(2) extraction process
More than three the flavor, Semen Ziziphi Spinosae coarse grain, Ganoderma decoction pieces mix with Folium Ginseng after being ground into coarse powder, decoct with water 1-3 time, each 0.5-1 hour, add 8-12 times of water gaging, collecting decoction at every turn, the 100-300 mesh sieve filters, filtrate is condensed into the clear paste that relative density is 1.10-1.20 (80 ℃), adds ethanol after the cooling and is 50%-70%, standing over night to containing the alcohol amount.Getting the supernatant decompression recycling ethanol does not extremely have pure flavor, and is condensed into the thick paste that relative density is 1.30-1.35 (80 ℃), and vacuum drying is crossed 40 mesh sieves after pulverizing, and gets dry extract;
(3) formulation preparation
Get above-mentioned dry extract, add acceptable pharmaceutic adjuvant on the pharmaceutics, with conventional system
Pharmaceutical worker's skill is prepared into tablet, granule, capsule, soft capsule.
As claim 1,2,3 described pharmaceutical compositions and preparation thereof hypnotic, improve immunocompetence, central nervous system disease aspect in application.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510008709 CN1283281C (en) | 2005-02-24 | 2005-02-24 | Medicinal composition containing wild jujube seed, lucid ganoderma and ginseng leaf and its preparing process and use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510008709 CN1283281C (en) | 2005-02-24 | 2005-02-24 | Medicinal composition containing wild jujube seed, lucid ganoderma and ginseng leaf and its preparing process and use |
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| CN1682983A true CN1682983A (en) | 2005-10-19 |
| CN1283281C CN1283281C (en) | 2006-11-08 |
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| CN 200510008709 Expired - Fee Related CN1283281C (en) | 2005-02-24 | 2005-02-24 | Medicinal composition containing wild jujube seed, lucid ganoderma and ginseng leaf and its preparing process and use |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637265B (en) * | 2009-08-17 | 2012-07-18 | 北京同仁堂健康药业股份有限公司 | Health food used for improving sleeping |
| WO2013155716A1 (en) * | 2012-04-20 | 2013-10-24 | 江苏安惠生物科技有限公司 | Capsule to improve sleep |
| CN104013692A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Traditional Chinese medicinal formula for improving sleeping |
| CN104223066A (en) * | 2014-09-02 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for improving sleeping |
| CN106728962A (en) * | 2016-12-28 | 2017-05-31 | 重庆硒旺华宝生物科技有限公司 | A kind of pharmaceutical composition of strengthen immunity and its application |
-
2005
- 2005-02-24 CN CN 200510008709 patent/CN1283281C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101637265B (en) * | 2009-08-17 | 2012-07-18 | 北京同仁堂健康药业股份有限公司 | Health food used for improving sleeping |
| WO2013155716A1 (en) * | 2012-04-20 | 2013-10-24 | 江苏安惠生物科技有限公司 | Capsule to improve sleep |
| CN104013692A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Traditional Chinese medicinal formula for improving sleeping |
| CN104223066A (en) * | 2014-09-02 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for improving sleeping |
| CN106728962A (en) * | 2016-12-28 | 2017-05-31 | 重庆硒旺华宝生物科技有限公司 | A kind of pharmaceutical composition of strengthen immunity and its application |
| CN106728962B (en) * | 2016-12-28 | 2021-01-05 | 重庆硒旺华宝生物科技有限公司 | Pharmaceutical composition for enhancing immunity and application thereof |
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| Publication number | Publication date |
|---|---|
| CN1283281C (en) | 2006-11-08 |
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