CN1682775A

CN1682775A - Eucommia bark tablet and its preparing method

Info

Publication number: CN1682775A
Application number: CN 200410017639
Authority: CN
Inventors: 王介庆
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-04-13
Filing date: 2004-04-13
Publication date: 2005-10-19

Abstract

The eucommia bark tablet consists of the extract of eucommia bark, common jujube seed, fleeceflower vine, kudzu vine root, oyster and other Chinese medicinal materials as well as lactose, fine silicon gel powder, sodium carboxymethyl starch and other supplementary material. The preparation process includes pre-treatment, extraction and concentration, spray drying, pelletizing and tabletting, coating and other steps. The eucommia bark tablet of the present invention has the functions of invigorating liver and kidney, strengthening physique, tranquilizing, etc. and has special curative effect on insomnia and dreaminess, kidney deficiency, lumbago, hypertension and other diseases.

Description

A kind of Cortex Eucommiae tablet and preparation method thereof

Technical field

The present invention relates to a kind of tablet and preparation method thereof, relate in particular to Cortex Eucommiae tablet and preparation method thereof.

Background technology

The Cortex Eucommiae is a kind of famous and precious medical material, China all plants in most of area, because its sweet in the mouth, warm in nature, the tool invigorating the liver and kidney, effects such as bone and muscle strengthening, be widely used in treating the sexual impotence of the soft unable and Liver and kidney deficiency and coldness of the soreness of waist and knee joint of deficiency of the liver and kindey or flaccidity, frequent micturition etc., the Cortex Eucommiae also has antiabortive, blood pressure lowering, diuresis, constipation there is peculiar curative effect, the chlorogenic acid that the Cortex Eucommiae contains, the acid of genipin infantile malnutrition, compositions such as caryophyllin bioside are health product, the primary raw material of food, has anti-flu, blood pressure lowering, anti-inflammation and sterilization, antiviral, effect such as anticancer, always paid attention to by doctor family, and the Cortex Eucommiae has no side effect to human body, among the people also have a tradition of making medicated diet with the Cortex Eucommiae, raising along with the social life level, people are more and more higher to the requirement of quality of life, health care consciousness is more and more stronger, because social competition's aggravation, general stress increases, insomniac group is on the increase, in this case, the application prospect of the Cortex Eucommiae is boundless, but, the Cortex Eucommiae decocts as the tcm prescription medicine traditionally, though have very strong specific aim, but take and inconvenience, and the utilization of effective ingredient is very insufficient, how the many personages of industry extract the effective ingredient exploitation pharmaceutical preparations of the Cortex Eucommiae is done a lot of work, as China's invention special " utilizing the method for effective ingredient in the supercritical carbon dioxide extraction Folium Eucommiae " and " nano whole eucommia meidicne and preparation method thereof ", fully adopting advanced technology on the effective component extracting, extraction effect is more satisfactory, but cost is higher, and mainly at Cortex Eucommiae single medicinal material, it is also undesirable to take effect.Chinese invention patent " leaves-of-eucommia natural health-care products and production technology thereof " and for example, utilize Folium Eucommiae exploitation health product, added other drugs such as Fructus Crataegi, increasing health care, conveniently take the aspect and done useful exploration, but reasonable not enough on medicine collocation and function balance.

Summary of the invention

For overcoming above-mentioned technological deficiency, give full play to the medicinal efficacy of the Cortex Eucommiae, according to motherland's Chinese medicine achievement in research and modern science and technology, development function balance, compatibility rationally, the compound health-care tablet of taking convenience, be the problem to be solved in the present invention.Another object of the present invention is its preparation method of this Cortex Eucommiae tablet.Its technical scheme is: a kind of Cortex Eucommiae tablet, form by adjuvants such as the extract of Chinese medicines such as the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, Rhizoma Chuanxiong and diluent, flowable, disintegrating agents; It forms proportioning is 3 parts of the Cortexs Eucommiae, 3 parts of Semen Ziziphi Spinosaes, 3 parts of Caulis Polygoni Multiflori, 3 parts of Radix Puerariaes, 3 parts of Concha Ostreaes, 3 parts of Semen Cassiaes, 2 parts of Rhizoma Chuanxiongs;

Used adjuvant diluent, flowable, disintegrating agent are respectively lactose, micropowder silica gel, carboxymethylstach sodium; ,

A kind of Cortex Eucommiae method for preparing tablet thereof comprises following step:

1. select the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, the Rhizoma Chuanxiong seven flavor medicine material in pure tunnel, pre-treatment such as carry out roguing, cleaning, cutting in advance, cut into slices, smash to pieces;

2. seven flavor medicine materials such as the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, Rhizoma Chuanxiong are pressed the said ratio weighing, drop in the multi-function extractor, soak, be heated to the back filter liquor body that boils, residue adds water again and is heated to the back filter liquor body that boils, and merges the liquid that leaches for twice and is extracting solution;

3. said extracted liquid is concentrated, make to proportion be 1.10-1.15;

4. concentrated solution is carried out spray drying and get extract powder;

5. first preheating boiling granulating machine adds above-mentioned extract powder, and the lactose (diluent), micropowder silica gel (flowable), the carboxymethylstach sodium adjuvants such as (disintegrating agents) that water are modulated into rare thick liquid spray into again, and carry out boiling granulating;

6. granulate: make mesh sieve by 20-60

7. above-mentioned garbled particulate matter is added suitable lubricant magnesium stearate, carry out tabletting behind the mix homogeneously;

8. above-mentioned tablet adding hydroxypropyl cellulose and food coloring are carried out film coating;

The Cortex Eucommiae among the present invention has invigorating the liver and kidney, bone and muscle strengthening, effects such as antihypertensive diuretic, Semen Ziziphi Spinosae has tonifying liver, mind calming, arresting sweating, the effect of promoting the production of body fluid, Caulis Polygoni Multiflori has nourishing blood to tranquillize the mind, the effect of dispelling wind and removing obstruction in the collateral, Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, the effect of yang invigorating antidiarrheal, the Concha Ostreae tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, the Semen Cassiae clearing away heat to improve acuity of vision, loosening bowel to relieve constipation, the Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, adopt the Cortex Eucommiae sheet of above-mentioned prepared to give full play to the effect of the medical material of respectively distinguishing the flavor of, effect is better after compatibility is synthetic, to lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement, hypertension, restlessness of asrhenia type and insomnia, the palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty, insomnia and dreamful sleep, the blood deficiency general pain, rheumatic arthralgia, skin pruritus, the fever caused by exogenous pathogens headache, stiff nape and back, measles without adequate eruption, hematodiarrhoea, have loose bowels, vertigo and tinnitus, the scrofula sucutaneous nodule, spontaneous sweating, the seminal emission metrorrhagia and leukorrhagia, the stomachache acid regurgitation, the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision, symptoms such as constipation have good curative effect, especially to restlessness of asrhenia type and insomnia, insomnia and dreamful sleep, lumbago due to renal deficiency, hypertension etc. have special-effect, take for a long time as health product and can improve sleep, blood pressure regulation, relaxing muscles and tendons to promote blood circulation, kidney-reinforcing Yang strengthening.

The specific embodiment

1 selects the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, the Rhizoma Chuanxiong seven flavor medicine material in pure tunnel, each medical material is carried out roguing, cleaning, with Cortex Eucommiae fleece-flower root rattan be cut into segment, with Radix Puerariae and Rhizoma Chuanxiong cut into pieces, with Semen Cassiae smash skin to pieces, Concha Ostreae is broken into pieces stand-by;

2 carry out weighing with above-mentioned stand-by raw material according to the ratio of 3 parts of the Cortexs Eucommiae, 3 parts of Semen Ziziphi Spinosaes, 3 parts of Caulis Polygoni Multiflori, 3 parts of Radix Puerariaes, 3 parts of Concha Ostreaes, 3 parts of Semen Cassiaes, 2 parts of Rhizoma Chuanxiongs, drop in the multi-function extractor, add 8 times of water gagings, soaked 1 hour, be heated to the timing again of boiling and leached liquid in 1 hour, residue adds 6 times of water gagings again and extracts 1 hour elimination residue, merges extracted twice liquid;

4 concentrate said extracted liquid, make to proportion be 1.10-1.15;

5 carry out spray drying with concentrated solution gets extract powder, and its parameter is: moisture≤3.5% of 18000 rev/mins of rotating speeds, 185 ℃ of inlet temperature, 85 ℃ of leaving air temps, powder delivery;

6 preheating boiling granulating machines add above-mentioned spray-dired extract powder;

7 waters are with adjuvant: lactose (diluent), micropowder silica gel (flowable), carboxymethylstach sodium (disintegrating agent) are modulated into rare thick liquid;

8 spray into adjuvant liquid on the spray drying powder, carry out boiling granulating;

9 granulate: make mesh sieve by 20-60;

10 will add suitable lubricant magnesium stearate through the above-mentioned particulate matter of screening, carry out tabletting behind the mix homogeneously;

11 above-mentioned tablets add hydroxypropyl cellulose and food coloring carries out film coating.

Claims

1, a kind of Cortex Eucommiae tablet is made up of adjuvants such as the extract of Chinese medicines such as the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, Rhizoma Chuanxiong and diluent, flowable, disintegrating agents;

2, Cortex Eucommiae tablet according to claim 1 is characterized in that it forms proportioning is 3 parts of the Cortexs Eucommiae, 3 parts of Semen Ziziphi Spinosaes, 3 parts of Caulis Polygoni Multiflori, 3 parts of Radix Puerariaes, 3 parts of Concha Ostreaes, 3 parts of Semen Cassiaes, 2 parts of Rhizoma Chuanxiongs;

3, Cortex Eucommiae tablet according to claim 1 is characterized in that used adjuvant diluent, flowable, disintegrating agent are respectively lactose, micropowder silica gel, carboxymethylstach sodium;

4, the preparation method of a kind of Cortex Eucommiae tablet according to claim 1 is characterized in that may further comprise the steps:

(1) selects the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, the Rhizoma Chuanxiong seven flavor medicine material in pure tunnel, pre-treatment such as carry out roguing, cleaning, cutting in advance, cut into slices, smash to pieces;

(2) seven flavor medicine materials such as the Cortex Eucommiae, Semen Ziziphi Spinosae, Caulis Polygoni Multiflori, Radix Puerariae, Concha Ostreae, Semen Cassiae, Rhizoma Chuanxiong are pressed the proportioning weighing, drop in the multi-function extractor, soak, be heated to the back filter liquor body that boils, residue adds water again and is heated to the back filter liquor body that boils, and merges the liquid that leaches for twice and is extracting solution;

(3) said extracted liquid is concentrated, make to proportion be 1.10-1.15;

(4) concentrated solution is carried out spray drying and get extract powder;

(5) first preheating boiling granulating machine adds above-mentioned extract powder, and the adjuvant such as lactose, micropowder silica gel, carboxymethylstach sodium that again water is modulated into rare thick liquid sprays into, and carries out boiling granulating;

(6) granulate: make mesh sieve by 20-60; To add suitable lubricant magnesium stearate through the above-mentioned granule of screening, carry out tabletting behind the mix homogeneously;

(7) above-mentioned tablet adding hydroxypropyl cellulose and food coloring are carried out film coating.