CN1660134A - Effervescence tablet of Xiao'er Anfen Huangnamin and preparation technique - Google Patents
Effervescence tablet of Xiao'er Anfen Huangnamin and preparation technique Download PDFInfo
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- CN1660134A CN1660134A CN2005100024740A CN200510002474A CN1660134A CN 1660134 A CN1660134 A CN 1660134A CN 2005100024740 A CN2005100024740 A CN 2005100024740A CN 200510002474 A CN200510002474 A CN 200510002474A CN 1660134 A CN1660134 A CN 1660134A
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- xiao
- crossed
- mesh sieve
- icing sugar
- effervescence tablet
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Abstract
An effervescent tablet of infantile Anfenhuangnamin contains proportionally paracetamol, artificial bezoar, chlorphenamine, maleate, tartric acid, stweetening agent, NaHCO, sugar and auxilairies. It has agreeable taste.
Description
Technical field
The present invention relates to a kind of effervescence tablet of Xiao ' er Anfen Huangnamin and preparation technology thereof.
Background technology
The present invention is a kind of new form of Chinese drug, according to the relevant drug act of China.Change dosage form as a kind of new drug research, Xiao ' er Anfen Huangnamin has multiple dosage form, the pediatric paracetamol,atificial cowbezoar and chlorphenamine maleate granule of one of former dosage form has been listed in the national drug standards (trying), standard No. WS-10001-(HD-0214)-2002, its character is white or yellow-white, and is easy to carry, and suitable adult takes, the child then needs divided dose oral, and it is also relatively poor to take inconvenience, mouthfeel.
Summary of the invention
Purpose of the present invention just provides a kind of effervescence tablet of Xiao ' er Anfen Huangnamin and preparation technology thereof, and the effervescent tablet children's is more pleased to take, and satisfies needs of medical treatment.
The object of the present invention is achieved like this;
One, the crude drug of effervescence tablet of Xiao ' er Anfen Huangnamin consists of;
Acetaminophen 125mg, artificial Calculus Bovis 5mg, chlorphenamine maleate 0.5mg, tartaric acid 0.4g, aspartame 28.5mg, NaHCO
30.5g, Icing Sugar 0.88g, right amount of auxiliary materials.
Two, effervescence tablet of Xiao ' er Anfen Huangnamin preparation technology comprises the steps:
(1) acetaminophen, artificial Calculus Bovis, chlorphenamine maleate, tartaric acid and 2/3 Icing Sugar of prescription amount are pulverized, crossed 100 orders, mixing adds an amount of binding agent and pigment solution then and granulates, and drying under reduced pressure is crossed 20 mesh sieve granulate again.
(2) with aspartame, the NaHCO of prescription amount
3Pulverize with 1/3 Icing Sugar, cross 100 mesh sieve mixings, add pigment aqueous solution then and granulate, drying under reduced pressure is crossed 20 mesh sieve granulate again.
(3) powder and the 25mg Polyethylene Glycol that (1) and (2) is obtained, 35mg essence mixing, tabletting, promptly.
It is big that the present invention has overcome pediatric paracetamol,atificial cowbezoar and chlorphenamine maleate granule, and it is poor to take mouthfeel, the defective of children taking inconvenience, suitable especially children taking.
The specific embodiment
1, get acetaminophen 125mg, artificial Calculus Bovis 5mg, chlorphenamine maleate 0.5mg, tartaric acid 0.4g and Icing Sugar 0.5g pulverize separately are crossed 100 mesh sieves; mixing adds an amount of Polyethylene Glycol and pigment solution, pelletize then; drying under reduced pressure is crossed 20 mesh sieve granulate.
2, with aspartame 28.5mg, NaHCO
30.5g, cross 100 mesh sieves with Icing Sugar 0.38g pulverize separately, with above three kinds of raw material mix homogeneously, 1mg pigment furnishing aqueous solution is added, carry out pelletize, drying under reduced pressure is crossed 20 mesh sieve granulate then.
3, add Polyethylene Glycol 25mg in the granulate that (1) and (2) is obtained, essence 35mg mix homogeneously carries out tabletting, promptly obtains finished product.
Claims (2)
1, a kind of effervescence tablet of Xiao ' er Anfen Huangnamin, its crude drug consists of: acetaminophen 125mg, artificial Calculus Bovis 5mg, chlorphenamine maleate 0.5mg, tartaric acid 0.4g, aspartame 28.5mg, NaHCO
30.5g, Icing Sugar 0.88g, right amount of auxiliary materials.
2, the preparation technology of the described effervescence tablet of Xiao ' er Anfen Huangnamin of a kind of claim 1 the steps include:
(1) acetaminophen, artificial Calculus Bovis, chlorphenamine maleate, tartaric acid and 2/3 Icing Sugar of prescription amount are pulverized, crossed 100 orders, mixing adds an amount of binding agent and pigment solution then and granulates, and drying under reduced pressure is crossed 20 mesh sieve granulate again;
(2) with aspartame, the NaHCO of prescription amount
3Pulverize with 1/3 Icing Sugar, cross 100 mesh sieve mixings, add pigment aqueous solution then and granulate, drying under reduced pressure is crossed 20 mesh sieve granulate again;
(3) granule and the 25mg Polyethylene Glycol that (1) and (2) is obtained, 35mg essence mixing, tabletting, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100024740A CN1660134A (en) | 2005-01-24 | 2005-01-24 | Effervescence tablet of Xiao'er Anfen Huangnamin and preparation technique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100024740A CN1660134A (en) | 2005-01-24 | 2005-01-24 | Effervescence tablet of Xiao'er Anfen Huangnamin and preparation technique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1660134A true CN1660134A (en) | 2005-08-31 |
Family
ID=35009873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005100024740A Pending CN1660134A (en) | 2005-01-24 | 2005-01-24 | Effervescence tablet of Xiao'er Anfen Huangnamin and preparation technique |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1660134A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100574747C (en) * | 2005-09-23 | 2009-12-30 | 浙江工业大学 | A kind of pediatric paracetamol artifical low-bezoar and chlorphenzmine maleategel preparation and preparation method thereof |
| CN101982179A (en) * | 2010-11-04 | 2011-03-02 | 海南新中正制药有限公司 | Xiao er Anfen Huang Namin granule and preparation method thereof |
| CN102475719A (en) * | 2010-11-29 | 2012-05-30 | 神威药业有限公司 | Drug composition for treating children upper respiratory tract infection, and preparation method thereof |
| CN107669655A (en) * | 2017-10-31 | 2018-02-09 | 广州市桐晖药业有限公司 | A kind of chlorphenamine maleate composition and preparation method thereof |
-
2005
- 2005-01-24 CN CN2005100024740A patent/CN1660134A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100574747C (en) * | 2005-09-23 | 2009-12-30 | 浙江工业大学 | A kind of pediatric paracetamol artifical low-bezoar and chlorphenzmine maleategel preparation and preparation method thereof |
| CN101982179A (en) * | 2010-11-04 | 2011-03-02 | 海南新中正制药有限公司 | Xiao er Anfen Huang Namin granule and preparation method thereof |
| CN101982179B (en) * | 2010-11-04 | 2012-07-25 | 海南新中正制药有限公司 | Xiao er Anfen Huang Namin granule |
| CN102475719A (en) * | 2010-11-29 | 2012-05-30 | 神威药业有限公司 | Drug composition for treating children upper respiratory tract infection, and preparation method thereof |
| CN107669655A (en) * | 2017-10-31 | 2018-02-09 | 广州市桐晖药业有限公司 | A kind of chlorphenamine maleate composition and preparation method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |