CN1651030A - Antivirus effervescent tablet and its preparation method - Google Patents
Antivirus effervescent tablet and its preparation method Download PDFInfo
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Abstract
An antiviral effervescent tablet contains the extracts and volatile oil of 9 Chinese-medicinal materials including isatis root, gypsum, reed rhizome, rehmannia root, etc. and the medical auxiliary consisting of acid source, alkali source, sweetening agent, flavouring and lubricant. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of antivirus effervescence tablet and preparation method thereof.
Technical background
Flu is many because of experiencing ailment said due to cold or exposure (comprising wind heat and wind and cold) or when infecting due to the row virus, heating is modal symptom, and all the other are as seen nasal obstruction, watery nasal discharge, headache, cough, general malaise etc. still.The Chinese and western drugs of treatment flu is comparatively various, and pays attention to heat-clearing and toxic substances removing, inhibiting bacteria and diminishing inflammation, antivirus action more, the treatment flu is had certain effect, but belong to symptomatic treatment more, and for cold virus itself, still lack ideal effect.Its Chinese medicine and western medicine is used treatment flu such as antiviral, antibiotics, antiallergic, antihistamine always, and the symptomatic treatment of cold virus is the most extensive with antipyretic-antalgic agent use, contains salicylic acid, as aspirin more; The acetophenone amine is as acetaminophen; Pyrazolone is as aminophenazone etc.As compound recipe patent medicine have immediate effect that cold capsule, contac, health get, paracetamol etc.Its common feature is a symptomatic treatment, and refrigeration function is very fast, and improves symptoms such as heating, headache, nasal obstruction, but finally still will lean on the spontaneous recovery of human autoimmune power.Such medicine has limited its scope of application owing to there is untoward reaction irritated, sleepy and in various degree.Especially in recent years some drugs more causes people's attention because of the untoward reaction that contains due to the PPA composition is stopped use.The appearance of influenza vaccines, the treatment for this disease once provides a powerful mean, but because the variability of virus makes the treatment of primary disease increase difficulty.Recently have the Chinese medicine chaste tree to prevent injection, injection of Radix Bupleuri etc. are used for cold, fever, onset like than ball, loose, electuary, oral liquid be rapid, but needs intramuscular injection, limited the scope of application.Therefore, constantly release anti-flu novel formulation and still belong to necessity.By contrast, the advantage of oral preparation of Chinese traditional medicinal treatment flu is admitted by common people.Reliable except that curative effect, portably use convenient, its basic reason is at the different causes of disease, dialectical executing controlled, pay attention to patient's intrinsic resistance adjustment, the incomparable advantage of Western medicine is arranged.
The advantage of the existing granule of effervescent tablet has the characteristics of tablet again, be to be a kind of tablet that disintegrating agent is made with the effervescent material, in water, can produce a large amount of bubbles, and can dissolve in the short period of time, have that drug effect is rapid, bioavailability is high, convenient carrying, the patient who is specially adapted to child, old man and can not swallows solid preparation, so effervescent tablet has the dosage form novelty, the characteristics that market prospect is wide.
In the preparation process of effervescent tablet, main difficult point is how to choose the ratio of principal agent and pharmaceutic adjuvant, and messenger drug is with under the less situation of supplementary product consumption, and the effervescent speed of effervescent tablet is fast, foaming effect good.
Summary of the invention
For these reasons, the ratio of pharmaceutic adjuvant effervescent that research worker of the present invention has been passed through the further investigation comparative optimization, need not to add other filler during formulation preparation, the relevant regulations that all meets effervescent tablet compressibility, dissolubility, mouthfeel and disintegration effervescent tablet that makes; The present invention extracts nine flavor Chinese medicines such as Radix Isatidis, Gypsum Fibrosum and obtains extract, according to the extract physicochemical properties that obtain effervescent pharmaceutic adjuvant consumption is screened again, obtain the optimal proportion scope, fast according to the effervescent tablet effervescent speed that proportion of the present invention is prepared, foaming effect good, mouthfeel good.
The object of the invention be to provide a kind of efficient, stable, use antivirus effervescence tablet easy to carry.
The present invention also provides the preparation method of above-mentioned effervescent tablet.
The present invention is achieved through the following technical solutions:
One. process recipes
(1) crude drug proportioning weight portion of the present invention is:
Radix Isatidis 36, Gypsum Fibrosum 16, Rhizoma Phragmitis 17, Radix Rehmanniae 9, Radix Curcumae 7, the Rhizoma Anemarrhenae 7, Rhizoma Acori Graminei 7, Herba Pogostemonis 8, Fructus Forsythiae 13;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and collected volatile oil and volatile oil emulsion simultaneously, add 6 times of amounts of water the 2nd time, decocted 80 minutes, collecting decoction is concentrated into an amount of, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying, to collect volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 6.0%-22.0%, and pharmaceutic adjuvant is 78.0%-94.0%, and wherein acid was 32.0%-38.0% originally, and alkali was 43.0%-52.0% originally, and sweeting agent is 1.6%-1.9%, and correctives is 0.7%-1.0%, and lubricant is 0.7%-1.1%.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains antivirus effervescence tablet.
Two. check and analysis
According to standard WS
3[assay] item method of-49 (X-39)-92 (Z) is carried out check and analysis.
Experimental result sees Table 1
Table 1 antivirus effervescence tablet assay
Phillyrin content meansigma methods
Group
Mg/ sheet mg/ sheet
1 0.039
2 0.042 0.040
3 0.040
Conclusion: show that by above-mentioned check and analysis experiment technology of the present invention has practical significance.
Three. principal agent of the present invention and pharmaceutic adjuvant determination of ratio
The experimental program design: if be lower than 5% according to our experiment principal agent ratio, the drug effect of effervescent tablet is bad, and main ratio is higher than 24%, and the non-conformity of quality of effervescent tablet closes requirement, and therefore, we experimentize on principal agent proportion 5%-24% scope basis.
Scheme 1: drug content 5%, pharmaceutic adjuvant are 95.0%, and wherein acid was 38.5% originally, and alkali was 53.0% originally, and sweeting agent is 1.8%, and correctives is 0.7%, and lubricant is 1.1%.
Scheme 2: drug content 5.5%, pharmaceutic adjuvant are 94.5%, and wherein acid was 38.2% originally, and alkali was 53.1% originally, and sweeting agent is 1.9%, and correctives is 0.7%, and lubricant is 0.6%.
Scheme 3: drug content 5.5%, pharmaceutic adjuvant are 94.5%, and wherein acid was 38.5% originally, and alkali was 53.0% originally, and sweeting agent is 1.7%, and correctives is 0.7%, and lubricant is 0.6%.
Scheme 4: drug content 6.0%, pharmaceutic adjuvant are 94.0%, and wherein acid was 38.0% originally, and alkali was 52.0% originally, and sweeting agent is 1.9%, and correctives is 1.0%, and lubricant is 1.1%.
Scheme 5: drug content 9.0%, pharmaceutic adjuvant are 91.0%, and wherein acid was 37.0% originally, and alkali was 50.5% originally, and sweeting agent is 1.7%, and correctives is 1.0%, and lubricant is 0.8%.
Scheme 6: drug content 15.0%, pharmaceutic adjuvant are 85.0%, and wherein acid was 36.5% originally, and alkali was 45.0% originally, and sweeting agent is 1.7%, and correctives is 0.9%, and lubricant is 0.9%.
Scheme 7: drug content 20.0%, pharmaceutic adjuvant are 80.0%, and wherein acid was 32.5% originally, and alkali was 44.4% originally, and sweeting agent is 1.7%, and correctives is 0.7%, and lubricant is 0.7%.
Scheme 8: drug content 22.0%, pharmaceutic adjuvant are 78.0%, and wherein acid was 32.0% originally, and alkali was 43.0% originally, and sweeting agent is 1.6%, and correctives is 0.7%, and lubricant is 0.7%.
Scheme 9: drug content 23.0%, pharmaceutic adjuvant are 77.0%, and wherein acid was 31.5% originally, and alkali was 42.5% originally, and sweeting agent is 1.6%, and correctives is 0.7%, and lubricant is 0.7%.
Scheme 10: drug content 24.0%, pharmaceutic adjuvant are 76.0%, and wherein acid was 31.0% originally, and alkali was 42.0% originally, and sweeting agent is 1.6%, and correctives is 0.7%, and lubricant is 0.7%.
1. the percentile mensuration of moisture absorption: effervescent tablet is very responsive to dampness, in process of production must strictness prevent the absorption of moisture, should select the adjuvant of the better proportion of hygroscopicity when therefore selecting effervescent adjuvant ratio.The glass exsiccator that the bottom is filled the sodium chloride supersaturated solution is put constant temperature 24h in the constant incubator of people 25C, and the relative humidity in this moment exsiccator is 75%.Put into the medicated powder of thick about 2mm in the weighing botle bottom of constant weight, in the glass exsiccator that is placed on the sodium chloride supersaturated solution of accurately weighing (the weighing bottle cap is opened), preserve in 25 ℃ of constant incubators, the timing weighing is calculated as follows the moisture absorption percentage rate.
The results are shown in Table 2
The moisture absorption percentage rate of table 2 different schemes medicated powder
12 hours 24 hours 48 hours 60 hours
Group
％ ％ ％ ％
Scheme 1 12.34 14.87 17.14 19.27
Scheme 2 12.06 14.51 17.08 19.22
Scheme 3 10.14 13.42 16.91 19.04
Scheme 4 9.06 10.28 11.87 13.24
Scheme 5 8.75 10.04 11.26 12.84
Scheme 6 8.49 9.89 10.75 11.76
Scheme 7 8.01 9.75 10.41 11.29
Scheme 8 7.99 9.14 10.24 10.89
Scheme 9 6.54 9.87 12.36 15.87
Scheme 10 6.12 9.98 13.64 16.98
Brief summary: by above-mentioned hygroscopicity experiment, we determine that tentatively the moisture absorption degree of scheme 1,2,3,9,10 is bigger, are unfavorable for the storage of effervescent tablet.
2. the effervescent tablet evaluation of different schemes
With the principal agent and the pharmaceutic adjuvant tabletting of above-mentioned different schemes, the effervescent tablet that is prepared into to be estimated, evaluation result sees Table 3:
Table 3 different schemes effervescent tablet evaluation result
Group mouthfeel foaming effect dissolubility disintegration time (branch)
Scheme 1 general foam volume is big, dissipates slowly 1.1
Scheme 2 general foam volumes are big, dissipate slowly 1.4
Scheme 3 is can foam suitable, dissipates fast 1.4
Scheme 4 good foams are suitable, dissipate fast 1.5
Scheme 5 good foams are suitable, dissipate fast 1.7
Scheme 6 good foams are suitable, dissipate fast 1.8
Scheme 7 good foams are suitable, dissipate fast 1.8
Scheme 8 general foams are suitable, dissipate fast 2.1
Scheme 9 is good job not, the rare granule 4.8 of foam
Scheme 10 is good job not, the rare granule 6.5 of foam
Brief summary: illustrate further scheme 4 to 8 by above-mentioned experiment, meet the requirement of effervescent tablet.
3. physical appearance relatively
The medicated powder of getting the mix homogeneously of different schemes is exposed under the external environment, and external condition keeps 20 ℃-25 ℃ of temperature, keeps humidity 40%-60%, exposes 12 days, observes the physical appearance after 12 days, the results are shown in Table 4;
Get the medicated powder of the mix homogeneously of different schemes, be packaged in the bottle, closed vial also stores under 65 ℃ of temperature, observes the physical appearance after 3 days, the results are shown in Table 4:
Physical appearance relatively under table 4 varying environment
Group exposes the physical change of physical change after airtight 3 days after 12 days
Scheme 1 no caking phenomenon, mobile poor, there is a little change color not have caking phenomenon, can free-flow, a little change color is arranged
Scheme 2 no caking phenomenons, mobile poor, there is a little change color that a little change color is arranged
Scheme 3 no caking phenomenons, mobile poor, there is a little change color that a little change color is arranged
Scheme 4 no caking phenomenons can free-flow, and no change color does not have caking phenomenon, can free-flow, and no change color
Scheme 5 no caking phenomenons can free-flow, and no change color does not have caking phenomenon, can free-flow, and no change color
Scheme 6 no caking phenomenons can free-flow, and no change color does not have caking phenomenon, can free-flow, and no change color
Scheme 7 no caking phenomenons can free-flow, and no change color does not have caking phenomenon, can free-flow, and no change color
Scheme 8 no caking phenomenons can free-flow, and no change color does not have caking phenomenon, can free-flow, and no change color
Scheme 9 cakings are more, can not flow, and a part of variable color caking is more, can not flow some variable color
Scheme 10 cakings are more, can not flow, and a part of variable color caking is more, can not flow some variable color
Brief summary: show scheme 4 to 9 composite effervescent sheet requirements by the physical appearance experiment.
Acid in the above-mentioned experiment is former, alkali is former, sweeting agent, correctives, lubricant use the replacement of effervescent pharmaceutic adjuvant, obtains data and results change is little.
Conclusion: by above-mentioned experiment, we carry out the data statistics of science, final definite crude drug extract is 6.0%-22.0%, pharmaceutic adjuvant is 78.0%-94.0%, and wherein acid was 32.0%-38.0% originally, and alkali was 43.0%-52.0% originally, sweeting agent is 1.6%-1.9%, correctives is 0.7%-1.0%, and lubricant is 0.7%-1.1%, and this proportion belongs to the proportion of antivirus effervescence tablet the best of the present invention.
Four. pharmacology embodiment
Embodiment 1
Adopt half intracorporal method to do the antivirus action test
The experiment reagent: antivirus effervescence tablet (Tianzhijiao Medication Development Co., Ltd., Guangdong's laboratory provides), per 1 is equivalent to crude drug 4.285g;
Antivirus oral liquid (Benxi, Liaoning pharmaceutical factory), every 10ml is equivalent to crude drug 4.285g;
Influenza A virus (A/ capital anti-/ 44/89), Influenza B virus (second/capital anti-/ 3/91) derive from health and epidemic prevention station Viral Laboratory, Guangdong Province.
(1) to the influence of influenza A virus: half intracorporal method is adopted in experiment, three dosage groups of antivirus effervescence tablet 2.5,1.0,0.5g/L, positive controls antivirus oral liquid 2.5,1.0,0.5g/L, normal control group and virus control group, the medicine of variable concentrations is directly acted on virus respectively, be inoculated in the chick embryo allantoic cavity immediately, with paraffin sealing-in kind hole, put 37 ℃ of incubators and cultivate 48h, collect the urine of every embryo, with the test of 0.5% chicken erythrocyte agglutination, judge the antiviral activity of medicine, the results are shown in Table 5.
(2) to the influence of Influenza B virus: inoculation method, drug dose are tested with influenza A virus.The results are shown in following table 5.
Two kinds of preparations of table 5 compare the effect of influenza virus
Group dosage (g/L) influenza A virus Influenza B virus
2.5 - -
Antivirus effervescence tablet 1.0--
0.5 - +
2.5 - -
Antivirus oral liquid 1.0++
0.5 ++ +++
Virus control-++++++
Normal control---
Annotate :-represent virus-free growth ,+represent a small amount of viral growth, ++ represent more viral growth, +++represent a large amount of viral growths
Embodiment 2
Influence to mouse infection pneumonitis virus mortality rate
The experiment medicine: antivirus effervescence tablet (Tianzhijiao Medication Development Co., Ltd., Guangdong's laboratory provides), per 1 is equivalent to crude drug 4.285g;
Antivirus oral liquid (Benxi, Liaoning pharmaceutical factory), every 10ml is equivalent to crude drug 4.285g;
Experimental technique: get 90 of mices, be divided into 3 groups at random, 30 every group, after mice is anaesthetized with ether is slight, it is 1: 320 pneumonia of mice virus 0.04ml that every Mus collunarium gives titre, administration next day, administration group gastric infusion dosage is 0.65g crude drug/kg, matched group is irritated stomach with the 0.5ml normal saline, successive administration 7d, observe 20d, record animal dead number the results are shown in Table 6.
Table 6 mouse infection pneumonitis virus death condition
The group laboratory animal is counted the death toll per cent death loss
A % only
Normal saline 30 28 93.3
Antivirus oral liquid 30 23 76.7
Antivirus effervescence tablet 30 19 63.3
Embodiment 3
Separate heat test
The experiment medicine: antivirus effervescence tablet (Tianzhijiao Medication Development Co., Ltd., Guangdong's laboratory provides), per 1 is equivalent to crude drug 4.285g;
Antivirus oral liquid (Benxi, Liaoning pharmaceutical factory), every 10ml is equivalent to crude drug 4.285g;
Experimental technique: get the qualified rabbit of pre-thermometric, before test day is measured administration on request, behind the rectal temperature, press the body temperature random packet, oral administration gavage, dosage is 0.3g/kg.Except that the blank group, each organizes after the administration intravenous injection bacterial endotoxin 50EU/kg immediately, surveys rectal temperature once every 30min later on, with body temperature that different time is surveyed and administration precursor using warming therapy difference, for body temperature intensification value (body temperature descend 0.4 ℃ in interior person with 0), the results are shown in Table 7.
The influence that rabbit body temperature raises due to the table 7 pair bacterial endotoxin
Group basal body temperature/℃ high fever/℃ the highest intensification value/℃
Normal saline 38.36 ± 0.37 39.91 ± 0.30 1.54 ± 0.25
Antivirus oral liquid 38.56 ± 0.21 39.70 ± 0.36 1.17 ± 0.40
*
Antivirus effervescence tablet 38.70 ± 0.29 39.72 ± 0.28 1.01 ± 0.22
*
Compare with model group:
*P＜0.01
Conclusion: show that by above pharmacological evaluation antivirus effervescence tablet of the present invention has better pharmacological action.
Five. preparation embodiment
Embodiment 1
(1) crude drug of the present invention is:
Radix Isatidis 1286 grams, Gypsum Fibrosum 571 grams, Rhizoma Phragmitis 607 grams, Radix Rehmanniae 321 grams, Radix Curcumae 250 grams, the Rhizoma Anemarrhenae 250 grams, Rhizoma Acori Graminei 250 grams, Herba Pogostemonis 286 grams, Fructus Forsythiae 464 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 660 grams, and pharmaceutic adjuvant is 2340 grams, and wherein acid was succinic acid 945 grams originally, and alkali was potassium bicarbonate 1275 grams originally, and sweeting agent is protein sugar 48 grams, and correctives is Herba Menthae essence 21 grams, and lubricant is magnesium stearate 21 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 1000 of antivirus effervescence tablets.
Embodiment 2
(1) crude drug of the present invention is:
Radix Isatidis 1286 grams, Gypsum Fibrosum 571 grams, Rhizoma Phragmitis 607 grams, Radix Rehmanniae 321 grams, Radix Curcumae 250 grams, the Rhizoma Anemarrhenae 250 grams, Rhizoma Acori Graminei 250 grams, Herba Pogostemonis 286 grams, Fructus Forsythiae 464 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 600 grams, and pharmaceutic adjuvant is 2400 grams, and wherein acid was malic acid 975 grams originally, and alkali was potassium bicarbonate 1332 grams originally, and sweeting agent is mannitol 51 grams, and correctives is cream flavour 21 grams, and lubricant is Pulvis Talci 21 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 1000 of antivirus effervescence tablets.
Embodiment 3
(1) crude drug of the present invention is:
Radix Isatidis 1286 grams, Gypsum Fibrosum 571 grams, Rhizoma Phragmitis 607 grams, Radix Rehmanniae 321 grams, Radix Curcumae 250 grams, the Rhizoma Anemarrhenae 250 grams, Rhizoma Acori Graminei 250 grams, Herba Pogostemonis 286 grams, Fructus Forsythiae 464 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 450 grams, and pharmaceutic adjuvant is 2550 grams, and wherein acid was citric acid 1095 grams originally, and alkali was sodium bicarbonate 1350 grams originally, and sweeting agent is protein sugar 510 grams, and correctives is that Fructus Citri Limoniae essence 27 gram lubricants are micropowder silica gel 27 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 1000 of antivirus effervescence tablets.
Embodiment 4
(1) crude drug of the present invention is:
Radix Isatidis 1286 grams, Gypsum Fibrosum 571 grams, Rhizoma Phragmitis 607 grams, Radix Rehmanniae 321 grams, Radix Curcumae 250 grams, the Rhizoma Anemarrhenae 250 grams, Rhizoma Acori Graminei 250 grams, Herba Pogostemonis 286 grams, Fructus Forsythiae 464 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 270 grams, and pharmaceutic adjuvant is 2730 grams, and wherein acid was tartaric acid 1110 grams originally, and alkali was sodium carbonate 1515 grams originally, and sweeting agent is glucide (saccharin sodium) 510 grams, and correctives is orange essence 30 grams, and lubricant is magnesium stearate 24 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 1000 of antivirus effervescence tablets.
Embodiment 5
(1) crude drug of the present invention is:
Radix Isatidis 1286 grams, Gypsum Fibrosum 571 grams, Rhizoma Phragmitis 607 grams, Radix Rehmanniae 321 grams, Radix Curcumae 250 grams, the Rhizoma Anemarrhenae 250 grams, Rhizoma Acori Graminei 250 grams, Herba Pogostemonis 286 grams, Fructus Forsythiae 464 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 180 grams, and pharmaceutic adjuvant is 2820 grams, and wherein acid was tartaric acid 1140 grams originally, and alkali was sodium bicarbonate 1560 grams originally, and sweeting agent is cyclamate 57 grams, and correctives is Herba Menthae essence 30 grams, and lubricant is polyethylene glycol 6000 33 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 1000 of antivirus effervescence tablets.
Embodiment 6
(1) crude drug of the present invention is:
Radix Isatidis 1286 grams, Gypsum Fibrosum 571 grams, Rhizoma Phragmitis 607 grams, Radix Rehmanniae 321 grams, Radix Curcumae 250 grams, the Rhizoma Anemarrhenae 250 grams, Rhizoma Acori Graminei 250 grams, Herba Pogostemonis 286 grams, Fructus Forsythiae 464 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 660 grams, and pharmaceutic adjuvant is 2340 grams, and wherein acid was malic acid 960 grams originally, and alkali was potassium bicarbonate 1290 grams originally, and sweeting agent is aspartame 48 grams, and correctives is flavoring orange essence 21 grams, and lubricant is Macrogol 4000 21 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 1000 of antivirus effervescence tablets.
Embodiment 7
(1) crude drug of the present invention is:
Radix Isatidis 12860 grams, Gypsum Fibrosum 5710 grams, Rhizoma Phragmitis 6070 grams, Radix Rehmanniae 3210 grams, Radix Curcumae 2500 grams, the Rhizoma Anemarrhenae 2500 grams, Rhizoma Acori Graminei 2500 grams, Herba Pogostemonis 2860 grams, Fructus Forsythiae 4640 grams;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) preparation prescription of the present invention is:
The crude drug extract is 6000 grams, and pharmaceutic adjuvant is 24000 grams, and wherein acid was succinic acid 9750 grams originally, and alkali was sodium bicarbonate 13320 grams originally, and sweeting agent is steviol glycosides 510 grams, and correctives is Fructus Citri Limoniae essence 210 grams, and lubricant is Pulvis Talci 210 grams.
(4) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains 10000 of antivirus effervescence tablets.
Claims (2)
1. an antivirus effervescence tablet is characterized in that what it was made up of extract, volatile oil and the pharmaceutic adjuvant of Radix Isatidis, Gypsum Fibrosum, Rhizoma Phragmitis, Radix Rehmanniae, Radix Curcumae, the Rhizoma Anemarrhenae, Rhizoma Acori Graminei, Herba Pogostemonis, Fructus Forsythiae extraction; Its feature is that also the crude drug extract is 6.0%-22.0%, and pharmaceutic adjuvant is 78.0%-94.0%, and wherein acid was 32.0%-38.0% originally, alkali was 43.0%-52.0% originally, sweeting agent is 1.6%-1.9%, and correctives is 0.7%-1.0%, and lubricant is 0.7%-1.1%.
2. the preparation method of antivirus effervescence tablet according to claim 1, its feature may further comprise the steps:
(1) raw material medicines in portions by weight proportioning of the present invention is:
Radix Isatidis 36, Gypsum Fibrosum 16, Rhizoma Phragmitis 17, Radix Rehmanniae 9, Radix Curcumae 7, the Rhizoma Anemarrhenae 7, Rhizoma Acori Graminei 7, Herba Pogostemonis 8, Fructus Forsythiae 13;
(2) get above-mentioned 9 flavor Chinese medicines, decoct with water 2 times, add 8 times of amounts of water for the first time, decocted 1.5 hours, and simultaneously, collected volatile oil and volatile oil emulsion, add 6 times of amounts of water for the 2nd time, decocted collecting decoction 80 minutes, be concentrated in right amount, add ethanol and make precipitation, filter, collect decompression filtrate recycling ethanol, concentrate drying will be collected volatile oil and volatile oil emulsion is sprayed onto on the dry extract, mix homogeneously obtains the crude drug extract;
(3) the crude drug extract is added pharmaceutic adjuvant acid is former, alkali is former, sweeting agent, correctives, lubricant, mix homogeneously, tabletting obtains antivirus effervescence tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510002068 CN1651030A (en) | 2005-01-14 | 2005-01-14 | Antivirus effervescent tablet and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510002068 CN1651030A (en) | 2005-01-14 | 2005-01-14 | Antivirus effervescent tablet and its preparation method |
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| Publication Number | Publication Date |
|---|---|
| CN1651030A true CN1651030A (en) | 2005-08-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200510002068 Pending CN1651030A (en) | 2005-01-14 | 2005-01-14 | Antivirus effervescent tablet and its preparation method |
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| Country | Link |
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| CN (1) | CN1651030A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431596C (en) * | 2006-01-20 | 2008-11-12 | 丽珠医药集团股份有限公司 | Medicine composition for treating bird flu, its preparation method and use |
| CN106387597A (en) * | 2016-08-31 | 2017-02-15 | 重庆市秀山红星中药材开发有限公司 | Instant honeysuckle flower solid beverage and preparation method thereof |
-
2005
- 2005-01-14 CN CN 200510002068 patent/CN1651030A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431596C (en) * | 2006-01-20 | 2008-11-12 | 丽珠医药集团股份有限公司 | Medicine composition for treating bird flu, its preparation method and use |
| CN106387597A (en) * | 2016-08-31 | 2017-02-15 | 重庆市秀山红星中药材开发有限公司 | Instant honeysuckle flower solid beverage and preparation method thereof |
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