CN1634607A - Medical biomaterial and method for manufacturing the same - Google Patents
Medical biomaterial and method for manufacturing the same Download PDFInfo
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- CN1634607A CN1634607A CN 200310117759 CN200310117759A CN1634607A CN 1634607 A CN1634607 A CN 1634607A CN 200310117759 CN200310117759 CN 200310117759 CN 200310117759 A CN200310117759 A CN 200310117759A CN 1634607 A CN1634607 A CN 1634607A
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- enzyme
- biomaterial
- woven material
- collagenase
- dressing formulations
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- Chemical Or Physical Treatment Of Fibers (AREA)
Abstract
The invention relates to a medical biological material and its preparation method, in particular to a pasting material for treating burns, scalds, wounds and accelerating wound recovery. It makes the high purity chitofine as basic material, adopts non woven method to manufacture chitofine non woven material, and combines specific biological enzyme dressing to said non woven mateial by post woven arranging method to make it as medical functional biological pasting material.
Description
Technical field
The present invention relates to a kind of biomaterial for medical purpose and manufacture method thereof, especially a kind of burn, scald and wound of being used for the treatment of, can accelerating wound stick material.
Background technology
China every year is because of burn, the case of scalding and stabbing is countless, Therapeutic Method routinely, at burn, scald and site of injury apply the medicine of dephlogistication and promoting nuscle growth, use chemicals and antibiotic to sterilize, sterilization, in case of necessity wound is wrapped up in order to avoid infect deterioration, but still there is deficiency in these methods, as use chemicals that human body skin is had zest, cause skin allergy, the used dressing of wound dressing easily causes the wound surface of mouthful adhesion due to wound when changing dressings the dismounting gauze, bring new misery to patient, the appearance and the use of many anti gauzes are also arranged at present, but it can not there be compatible degraded with human-body biological again, therefore, slow to treating above-mentioned trauma effect, can not be satisfactory.In order to overcome this defective, industry has adopted various method.Disclosed a kind of paper mold dressing that adopts chitin as CN1162665A " chitin medical fibre paper and manufacture method thereof ".But because this scheme proposed the spinning of specific chitin and the manufacturing process of non-woven material emphatically, make technology comparatively complicated, and apply and be restricted.And actual effect also illustrates, simple chitin paper mold dressing assimilation effect in the sticking of wound is still not obvious.
Summary of the invention
One of order of the present invention: the medicinal functional biomaterial that provide a kind of and be used to burn, the wound of scald and wound sticks.
Two of order of the present invention: the manufacture method that a kind of above-mentioned medicinal functional biomaterial is provided.
The objective of the invention is to realize by following technical method:
With the high-purity chitosan fiber is base stock of the present invention, make with non-woven method and to contain the chitosan fiber non-woven material, adopt the method for fabric post-treatment again, specific enzyme dressing formulations is combined on the above-mentioned non-woven material, make it to become the medicinal functional biomaterial that can stick.
Specifically, adopt chitosan fiber, its molecular formula is [C
6H
11NO
4] n
1, it is the product of deacetylation, deacetylation＞90%, and the content of chitosan＞95% in the fiber, fiber linear density 1.2-2.5dtex, fibre length is 31-65mm, fibrous fracture intensity is 1.5-2.5CN.The water thorn or the needle fabric that adopt no spinning process to make, its thickness is 0.15-0.45mm, grammes per square metre is 20-80g/m
2
According to a kind of enzyme dressing formulations of following formulated, the content of its component and percentage by weight:
High section compound enzyme: 0.01-55%
Collagenase 0.01-50%
Proteinase-10 .01-45%
Distilled water surplus
Aforementioned carapace amino acid hydraulical needle or needle fabric are carried out functional treatment, and its technology is:
Carapace amino acid hydraulical needle or needle fabric → disinfect → biological enzyme formulation is handled (soaking 10-20 minute) → take off liquid → finished product (enzyme content 0.5-12g/m
2) promptly obtain the biomaterial of wanting required for the present invention.
Wherein:
1) carapace amino acid hydraulical needle, needle fabric are positioned over carry out ethylene oxide gas in the disinfection cabinet and disinfect 55 ℃ of temperature, relative humidity 80%, ethylene oxide gas (800g/L), time 4-6h, residual ethylene oxide＜10 μ g/g.
2) with ultraviolet lamp box sterilization, 30 minutes time.
Compare prior art, advantage of the present invention shows:
It is raw material that employing is extracted chitosan with marine organisms, utilize advanced technologies to make carapace amino acid hydraulical needle, needle fabric, put the medicinal functional biomaterial that obtains needs in order through sterilization and biological enzyme formulation again, treatment burn, scald and wound are had good function and curative effect, and sterilization, antiinflammatory, detumescence effect are obvious.Because of it is not a chemicals, so to skin wound nonirritant and allergic phenomena, the chemical property of chitosan and biological property and tissue are close, and human body is had no side effect, good biocompatibility, biodegradable is glucosamine, is absorbed the serum proteins that energy active adsorption wound surface is got rid of fully by human body, hemostasis and pain-relieving, promote the fell tissue growth, accelerate wound surface reparation and healing, even cicatrix is disappeared.Because this material is fibrous fine structure, softness, moisture absorption, ventilative, good with the wound surface adherence do not have hydrops under dressing, wound surface is kept dry.Compare with artificial skin with other medical dressing, easy to use, sticking apply comfortable, cure quick, evident in efficacy.
The specific embodiment:
The manufacture method process of medicinal functional biomaterial of the present invention is:
Adopt high density chitosan fiber, deacetylation＞90%, the content of chitosan＞95% in the fiber, fiber linear density is 1.2-2.5dtex, fibrous fracture intensity is 1.5-2.5CN, fibre length 31-65mm, water thorn, the needle fabric thickness made are 0.15-0.45mm, and Gram Mass is 20-80g/m
2This non-weaving cloth is disinfected earlier, be specially above-mentioned non-weaving cloth is positioned over and carry out ethylene oxide gas in the disinfection cabinet and disinfect 55 ℃ of temperature, relative humidity 80%, ethylene oxide gas (800g/L), time 4-6h, residual ethylene oxide＜10 μ g/g.The sterilization of reuse ultraviolet lamp box, 30 minutes time.
Then according to following recipe configuration finishing agent:
High section compound enzyme: 0.01-55%
Collagenase 0.01-50%
Proteinase-10 .01-45%
Distilled water surplus
The biological enzyme formulation arrangement that this product is configured was soaked 10-20 minute, take off liquid, oven dry (75-85 ℃) promptly obtains needed finished product, and (content of biological enzyme formulation is 0.5-12g/m
2).
Embodiment 1,
Adopt high density chitosan fiber, deacetylation＞90%, the content of chitosan＞95% in the fiber, fiber linear density is 1.2-2.5dtex, fibrous fracture intensity is 1.5-2.5CN, fibre length 31-65mm, water thorn, the needle fabric thickness made are 0.15-0.45mm, and Gram Mass is 20g/m
2This non-weaving cloth is disinfected earlier, be specially above-mentioned non-weaving cloth is positioned over and carry out ethylene oxide gas in the disinfection cabinet and disinfect 55 ℃ of temperature, relative humidity 80%, ethylene oxide gas (800g/L), time 4-6h, residual ethylene oxide＜10 μ g/g.The sterilization of reuse ultraviolet lamp box, 30 minutes time.
With following recipe configuration biological enzyme formulation (high section compound enzyme content is 15%, and collagenase content is 25%, and protease content is 5%, and distilled water is 55%).
The biological enzyme formulation arrangement that this product is configured was soaked 10 minutes, take off liquid, (content of biological enzyme formulation is 0.5-12g/m promptly to obtain needed finished product
2).
Embodiment 2,
Adopt high density chitosan fiber, deacetylation＞90%, the content of chitosan＞95% in the fiber, fiber linear density is 1.2-2.5dtex, fibrous fracture intensity is 1.5-2.5CN, fibre length 31-65mm, water thorn, the needle fabric thickness made are 0.15-0.45mm, and Gram Mass is 70g/m
2This non-weaving cloth is disinfected earlier, be specially above-mentioned non-weaving cloth is positioned over and carry out ethylene oxide gas in the disinfection cabinet and disinfect 55 ℃ of temperature, relative humidity 80%, ethylene oxide gas (800g/L), time 4-6h, residual ethylene oxide＜10 μ g/g.The sterilization of reuse ultraviolet lamp box, 30 minutes time.
With following recipe configuration biological enzyme formulation (high section compound enzyme content is 25%, and collagenase content is 25%, and protease content is 5%, and distilled water is 45%).
The biological enzyme formulation arrangement that this product is configured was soaked 20 minutes, take off liquid, (content of biological enzyme formulation is 0.5-12g/m promptly to obtain needed finished product
2).
Claims (5)
1, a kind of biomaterial for medical purpose adopts the chitosan fiber non-woven material as base material, it is characterized in that adopting the method for back arrangement, and specific enzyme dressing formulations is combined on the above-mentioned non-woven material, makes it to become the medicinal functional biomaterial that can stick.
2, biomaterial as claimed in claim 1 is characterized in that described enzyme dressing formulations comprises high section compound enzyme at least, collagenase and protease, and concrete ratio is:
High section compound enzyme: 0.01-55%
Collagenase 0.01-50%
Proteinase-10 .01-45%
Distilled water surplus
3, a kind of manufacture method of biomaterial as claimed in claim 1 is characterized in that its employing chitosan fiber non-woven material, adopts the method for fabric post-treatment again, and specific enzyme dressing formulations is combined on the above-mentioned non-woven material.
4, the manufacture method of biomaterial as claimed in claim 3 is characterized in that technical process is
A) the chitosan non-weaving cloth is disinfected;
B) biological enzyme formulation is handled (soaking 10-20 minute);
C) take off liquid;
D) finished product (enzyme content 0.5-12g/m
2).
5, as the manufacture method of claim 3 or 4 described biomaterials, it is characterized in that described enzyme dressing formulations prescription is:
High section compound enzyme: 0.01-55%
Collagenase 0.01-50%
Proteinase-10 .01-45%
Distilled water surplus
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310117759 CN1634607A (en) | 2003-12-30 | 2003-12-30 | Medical biomaterial and method for manufacturing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310117759 CN1634607A (en) | 2003-12-30 | 2003-12-30 | Medical biomaterial and method for manufacturing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1634607A true CN1634607A (en) | 2005-07-06 |
Family
ID=34843722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310117759 Pending CN1634607A (en) | 2003-12-30 | 2003-12-30 | Medical biomaterial and method for manufacturing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1634607A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346841C (en) * | 2005-12-22 | 2007-11-07 | *** | Surgical dressing |
| CN103768650A (en) * | 2014-01-26 | 2014-05-07 | 深圳市博立生物材料有限公司 | Wound regenerating and repairing bandage and manufacture method thereof |
| CN106563150A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
-
2003
- 2003-12-30 CN CN 200310117759 patent/CN1634607A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346841C (en) * | 2005-12-22 | 2007-11-07 | *** | Surgical dressing |
| CN103768650A (en) * | 2014-01-26 | 2014-05-07 | 深圳市博立生物材料有限公司 | Wound regenerating and repairing bandage and manufacture method thereof |
| CN106563150A (en) * | 2015-10-10 | 2017-04-19 | 如皋市启润运动用品有限公司 | Medical functional biological dressing sheet |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |