CN1634426A - Composition of fresh rehmannia root and rhubarb horsetails and preparation method thereof - Google Patents
Composition of fresh rehmannia root and rhubarb horsetails and preparation method thereof Download PDFInfo
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- CN1634426A CN1634426A CN 200410087645 CN200410087645A CN1634426A CN 1634426 A CN1634426 A CN 1634426A CN 200410087645 CN200410087645 CN 200410087645 CN 200410087645 A CN200410087645 A CN 200410087645A CN 1634426 A CN1634426 A CN 1634426A
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Abstract
The invention provides a composition of fresh rehmannia root and rhubarb horsetails and its preparation method for treating haemorrhagia, which is prepared from (by weight ratio) fresh rehmannia root 30-75, rhubarb horsetails 20-50 through water grilling concentration, grinding, mixing, drying, and granulation. The composition has no toxic and side actions, but has the advantages of short course of treatment, quick action, appreciable action, no recrudesce tendency, low cost and easiness in administration.
Description
Affiliated field
The present invention relates to Chinese herbal and crude drugs preparations, particularly Radix Rehmanniae and Radix Et Rhizoma Rhei composition and method of making the same.With the combination of Radix Rehmanniae and Radix Et Rhizoma Rhei combination or its extract, be to utilize both complementary functions, prevention, treatment interior-heat agitation, impairment of body fluid is thirsty, and macule is spitted blood epistaxis, upper respiratory tract hemorrhage, nose bleeding, diseases such as hemoptysis.Clearing away heat and promoting production of body fluid, cooling blood for hemostasis.Eliminating fire and detoxication, the clots absorbing latus rectum.
Background technology
Traditional Chinese herbal medicine is medical to be single less, mostly being compound recipe, being particular about monarch, is the main treatment disease with one, two flavor monarchs drug often, but because Chinese herbal medicine composition complexity, except that active ingredient, also have a large amount of impurity, even harmful material, have side effects, so that poison, need other ministerial drug assistants to make and eliminate the effects of the act, help to absorb, thereby the prescription volume is excessive, unfavorable use, also existence disappears, and this answers that toxic and side effects, and cancels out each other, reduce drug effect, be difficult to bring into play the real effect of principal agent, particularly absorption is slow, drug effect is low, demands urgently improving.
Radix Rehmanniae: be the fresh tuber of scrophulariaceae rehmannia glutinosa plant.Perennial herb, high 10-30 centimetre, all close by the long glandular hair of white.The root meat, be block.Ye Duojisheng, lotus throne is strong, and the long 1-2 of handle centimetre, blade falls the strong lanceolar of ovum to oblong.Long 3-10 centimetre, edge teeth is blunt or sharp, and stem leaf is little more than basal leaf.Be born in hillside and roadside, be mainly cultivation.Chemical analysis: the chemical analysis of Radix Rehmanniae, based on glycoside, wherein again based on cyclenes ether glycosides.From the bright Radix Rehmanniae, separated and drawn Herba Leonuri oxalene ether terpene glycosides, aucubin Camphor tree alcohol and Martynoside. A, B, kind of iridoid glycoside composition surplus the C, D etc. 10 is the highest with large, oblong sheet of silk with an appropriate message attached alcohol content, and contain D-glucose, D galactose, sucrose, saccharides such as stachyose, the highest with content of stachyose, other contains 20 several amino acids, glucamine, D-mannitol phosphoric acid, cupreol, daucosterol and unit and element etc.Pharmacological action: the Radix Rehmanniae water decoction forms the obvious inhibitory action of cell tool to Flos Rosae Rugosae in the mouse spleen.Can obviously promote activatory splenocyte DNA of con A and proteinic biosynthesis, people's lymphocyte transformation is had facilitation; Radix Rehmanniae can be corrected the increase of hyperthyroidism rat kidney beta-receptor quantity, and thyroid function is returned to normally, and the Radix Rehmanniae decoct is irritated stomach to rabbit can resist the decline of taking plasma corticosterone behind the dexamethasone continuously, and prevents the adrenal cortex atrophy; Radix Rehmanniae still has accelerates the propagation that mice pluripotential hemopoietic stem cell bone marrow granulocyte is made the group cell, differentiation.The property of medicine: sweet-bitter flavor, cold in nature.GUIXIN, liver, kidney channel.Function: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Clinical practice: be used for acute calenture, as the epidemic febrile disease heresy branch of joining the army, unconsciousness due to high fever, macule is not indistinct, and is mouthful thirsty, deep red tongue; The hemorrhage that is used for bleeding due to blood-heat.After one's own heart lung-heat is contained, and spits blood the urgent person of the epistaxis oncoming force; Be used for heart channel intenseness of heat, aphtha of the mouth and tongue, restlessness and thirst, the deficiency of YIN and diseases such as wind heat.Usage and dosage: for oral administration: fry in shallow oil soup 10-30 gram, smash juice or endure cream.External: an amount of, smash to apply or smash juice and be coated with.
Radix Et Rhizoma Rhei: different name general commonly used, Radix Et Rhizoma Rhei, yellow good, another name for Sichuan Province Radix Et Rhizoma Rhei, bright and beautiful civilian Radix Et Rhizoma Rhei.Be polygonum rheum palmatum, the root footpath and the root of Rheum tanguticum and Rheum officinale.Sorrel: perennial tall and big draft, the sturdy plumpness of rhizome.Stem is upright, and hollow is up to about 2 meters.Be born in mountain region border or grass slope, wild or cultivation; Rheum tanguticum: have another name called rheum tanguticum Tschircs, Beijing University's Huang, this kind and sorrel fairly similar, the main distinction is: blade drastic crack, sliver often are triangular shape lanceolar or narrow linear, and spray is tight, and be upwards upright, is close to stem.Be born in the more dark and damp place of mountain region border; Rheum officinale: have another name called RADIX ET RHIZOMA RHEI OFFICILALIS, todaiwo,rhizoma, refined Huang, this kind and last two kinds of main distinctions: basal leaf and shallow splitting, sliver are big profile of tooth or wide triangle; Ochrea is membranous, and is more transparent, on undercoat is arranged; Flower is bigger, pistac, and Fruit branch is carried out, and the Myriopteron extensum (Wight) K. Schum edge is opaque.Be born in mountain region border or grass slope.Chemical constituent: Radix Et Rhizoma Rhei contains anthraquinone derivative, tannin and organic acid etc., and dissociated anthraquinone has: chrysophanic acid, aloe-emodin, emodin, physcione, chrysophanol.Combined anthraquinone has: physcione-8-glucoside, aloe-emodin-8-glucoside, chrysophanol-1-glucoside etc.; The dianthracene ketones component has: sorrel dianthrone, A, B, C, D etc.Also resinous, epicatechin, epicatechol gallate, galloyl glucose etc.Pharmacological action: Radix Et Rhizoma Rhei has the effect of dropping, and this effect is decocted the influence of temperature and time, and Radix Et Rhizoma Rhei prolongs heat time heating time, and the effect of then dropping weakens, and is advisable in 30-60 minute so decoct.The composition that drops of Radix Et Rhizoma Rhei is a sennoside; Radix Et Rhizoma Rhei can promote bile secretion, and bilirubin and bile acid content are increased; Radix Et Rhizoma Rhei has effects such as antibacterium, fungus, virus, the has a broad antifungal spectrum of Radix Et Rhizoma Rhei, and with chrysophanic acid, the antibacterial action of emodin and aloe-emodin is the strongest in the antibacterial effective ingredient; Radix Et Rhizoma Rhei has obvious inhibitory action to multiple zoopery inflammation; Various zooperies show that Radix Et Rhizoma Rhei has anastalsis, can obviously shorten hemorrhage and clotting time, and its hemostasis effective ingredient is a chrysophanol, physcione, a-cachou extract and gallic acid; Chrysophanic acid and Radix Et Rhizoma Rhei have antitumor action, and its mechanism of action mainly is the oxidation and the dehydrogenation of anticancer; Zoopery shows that Radix Et Rhizoma Rhei also has effects such as the blood fat reducing diuresis protects the liver.The property of medicine: bitter in the mouth, cold in nature.Return stomach, large intestine, liver, spleen channel.Function: stasis removing, eliminating fire and detoxication, blue heat dampness removing, cooling blood for hemostasis.Clinical practice: be used for the solid cubic content constipation, distension and fullness in the abdomen; Be used for damp and hot stagnant dysentery, tenesmus; Be used for jaundice due to damp-heat, gonorrhea, edema; Be used for scorching all diseases on the pathogenic fire, as headache, conjunctival congestion and swelling pain is had sore throat, gingivitis, and aphtha of the mouth and tongue with constipation due to dry stool; Be used for the pyretic toxicity carbuncle, erysipelas, skin infection is scalded etc.In addition, existing Radix Et Rhizoma Rhei also is usually used in treating chronic renal insufficiency and uremia.How single oral with Radix Et Rhizoma Rhei powder.Usage and dosage: for oral administration, fry in shallow oil soup 3-12 gram, grind the 0.5-2 gram into powder, or the bubble drink.External: an amount of.
Summary of the invention
The present invention is directed to the prior art deficiency, utilize modern biochemical technology and Chinese medicine and pharmacy theory, a kind of Radix Rehmanniae and Radix Et Rhizoma Rhei composition and method of making the same are provided, Chinese herbal medicine Radix Rehmanniae and Radix Et Rhizoma Rhei are ground the synthetic powder in back, utilize the complementary effect of this two flavor Chinese herbal medicine, the extraction of the Chinese medicine Radix Rehmanniae is concentrated be equipped with Chinese herb rhubarb end composition compound preparation.Utilize this two flavors Chinese medicine complementary effect, treatment is because bleeding due to blood-heat, and the epistaxis due to the heart footpath intenseness of heat, depletion fire syndrome going up is spitted blood the spitting of blood symptom.
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 30-75, Radix Et Rhizoma Rhei 20-50.
It is main that Radix Rehmanniae can be extract cyclenes ether glycosides, has separated to draw Herba Leonuri oxalene ether terpene glycosides, aucubin Camphor tree alcohol and Martynoside. A from the bright Radix Rehmanniae, kind of iridoid glycoside composition surplus the B, C, D etc. 10, the highest with large, oblong sheet of silk with an appropriate message attached alcohol content, and contain the D-glucose, the D galactose, sucrose, saccharides such as stachyose are the highest with content of stachyose, other contains 20 several amino acids, glucamine, D-mannitol phosphoric acid, cupreol, daucosterol; Radix Et Rhizoma Rhei can be the extract anthraquinone derivative, tannin and organic acid etc., and dissociated anthraquinone has: chrysophanic acid, aloe-emodin, emodin, physcione, chrysophanol; Combined anthraquinone has: physcione-8-glucoside, aloe-emodin-8-glucoside, chrysophanol-1-glucoside etc.; The dianthracene ketones component has: sorrel dianthrone, A, B, C, D etc., also resinous, epicatechin, epicatechol gallate, galloyl glucose.
Radix Rehmanniae and Radix Et Rhizoma Rhei preparation method of composition, Radix Rehmanniae are fried in shallow oil water and are concentrated, and Radix Et Rhizoma Rhei powder grinds to the powder.The Radix Rehmanniae concentrated solution is mixed with Radix Et Rhizoma Rhei, and drying is made granule.
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions are different from existing Chinese herbal compound preparation, and reach test by experiment and confirm: these product have no side effect, short treating period, instant effect, effect is obviously, do not recur economical and convenient, clinical simple hemostasis relatively now, oral medicine and external hemostasis method cure the symptoms, not the disease essence difference, be fundamentally to remove interior-heat, removing heat from blood, hemostasis, clearing away heat and promoting production of body fluid, eliminating fire and detoxication, thereby remove the interior-heat agitation, impairment of body fluid is thirsty, the cause of disease of hematemesis and epistaxis.Treat tens of people, obvious effective rate 25%, cure rate 98.6%, effective percentage 100%.This technology has overcome the hemorrhage deficiency that waits disease of present treatment, for new gate has been opened in its extensive use, is suitable for penetration and promotion.
In addition, these product also have acute pancreatitis, cholecystitis, and acute icterohepatitis has therapeutical effect; Antitumor action is arranged, and its mechanism of action is the oxidation and the dehydrogenation of anticancer; The diuresis blood fat reducing is arranged, hepatoprotective effect.
Usage and dosage: warm boiled water: one day twice, half fully recovered in 2-5 days at every turn.
The specific embodiment:
Embodiment 1
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 6 grams, Radix Et Rhizoma Rhei 10 grams, sucrose 10 grams, usage and dosage: warm boiled water: one day twice, half fully recovered in 2-5 days at every turn.
Embodiment 2
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 12 grams, Radix Et Rhizoma Rhei 10 grams.Usage and dosage: warm boiled water: one day twice, half fully recovered in 2-5 days at every turn.
Embodiment 3
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 10 grams, Radix Et Rhizoma Rhei 10 grams, graperoot 15 grams.Flu-prevention and hemorrhage.Usage and dosage: warm boiled water: one day twice, half fully recovered in 2-5 days at every turn.
Embodiment 4
Radix Rehmanniae and Radix Et Rhizoma Rhei preparation method of composition, Radix Rehmanniae 10 grams are fried in shallow oil water and are concentrated, and Radix Et Rhizoma Rhei 6 gram powder grind to the powder, and the Radix Rehmanniae concentrated solution is mixed with Radix Et Rhizoma Rhei, and drying is made granule.
Embodiment 5
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions are used for the carrier of functional food, health product, medicine as intermediate.
Embodiment 6
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions are as the carrier of soft capsule, capsule, pill, tablet, electuary, injection or other dosage form.
Embodiment 7
Radix Rehmanniae and Radix Et Rhizoma Rhei compositions can add various medicines according to various objectives, as the carrier of multiple formulations.
Embodiment 8 (typical case history):
Woods XX man 16 years old, it is surplus to suffer from epistaxis 3 years, checks to local hospital successively, and treat with medicines such as etamsylates that can stop at that time, this product was taken in recurrence again afterwards after a while, healing on the three.
Cattle XX man 30 years old suffers from epistaxis for many years, and hemorrhage unconsciously often, once hospital treatment was diagnosed as dry nasal cavity, and with Fructus Gardeniae JINHUA ball, vitamin C is for oral administration, DeGrain, and this product was taken in recurrence afterwards after two months, cured in 3rd.
Woods XX man 32 years old, suffer from nose go out 25 years surplus, be heart channel intenseness of heat once to hospital diagnosis, depletion fire syndrome going up, dry nasal cavity is obeyed a clearing capsule, the andrenobazon tablet, it is not obvious to take effect, the time recurrence is arranged, took this product afterwards, healing on the three.
King XX man 32 years old, it is surplus to suffer from epistaxis 4 years, is difficult to during epistaxis stop, and once arrive hospital with the treatment of Laser Welding cauterization, stops blooding with hemostasis side is sour, effective at that time, continues hemorrhagely later, takes this product afterwards, healing on the three.
Rhizoma Zingiberis Recens X woman 19 years old, it is surplus to suffer from epistaxis 2 years, once at the Shenyang examination in hospital, is diagnosed as dry nasal cavity, and nasal mucosa is drawn up and is bled, once with hemostasis side acid, vitamin, Sanguis Draxonis capsule for oral administration, effective at that time, recur after 2 months, took this product afterwards, healing on the three.
King X woman 10 years old, it is surplus to suffer from epistaxis 1 year, once takes the andrenobazon sheet, vitamin C, a clearing capsule etc., DeGrain, this product was taken in recurrence afterwards often, cured in 3rd.
Borrow the X woman 20 years old, once repeatedly arrived examination in hospital, be diagnosed as depletion fire syndrome going up, dry nasal cavity, the blood capillary cracking is coated with outward with etamsylate, and peace for oral administration Lip river sheet, VITAMIN C TABLET short-term effectively in two to three months recur, and take this product afterwards, cure in 3rd.
Curative effect summary, this product taking convenience, curative effect is obvious, rapidly, does not recur, it is more than to remove patient's bleeding, even the fear of threat to life health, simultaneously also needn't for epistaxis at any time to the pollution of medicated clothing and hemorrhagely at work worry.Cure epistaxis at short notice, spit blood, the lighter obeys potion can cure (3-5 days), and heavy person obeys two doses promptly heal (5-10 days).
Claims (10)
1, Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 30-75, Radix Et Rhizoma Rhei 20-50.
2, according to described Radix Rehmanniae of claim 1 and Radix Et Rhizoma Rhei compositions, it is main that Radix Rehmanniae can be extract cyclenes ether glycosides, has separated to draw Herba Leonuri oxalene ether terpene glycosides from the bright Radix Rehmanniae, aucubin Camphor tree alcohol and Martynoside. A, B, C, kind of iridoid glycoside composition surplus the D etc. 10, the highest with large, oblong sheet of silk with an appropriate message attached alcohol content, and contain the D-glucose, the D galactose, sucrose, saccharides such as stachyose, the highest with content of stachyose, other contains 20 several amino acids, glucamine, D-mannitol phosphoric acid, cupreol, daucosterol; Radix Et Rhizoma Rhei can be the extract anthraquinone derivative, tannin and organic acid etc., and dissociated anthraquinone has: chrysophanic acid, aloe-emodin, emodin, physcione, chrysophanol; Combined anthraquinone has: physcione-8-glucoside, aloe-emodin-8-glucoside, chrysophanol-1-glucoside etc.; The dianthracene ketones component has: sorrel dianthrone, A, B, C, D etc., also resinous, epicatechin, epicatechol gallate, galloyl glucose.
3, according to described Radix Rehmanniae of claim 1 and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 6 grams, Radix Et Rhizoma Rhei 10 grams, sucrose 10 grams.
4, according to described Radix Rehmanniae of claim 1 and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 12 grams, Radix Et Rhizoma Rhei 10 grams.
5, according to described Radix Rehmanniae of claim 1 and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae 10 grams, Radix Et Rhizoma Rhei 10 grams, Rhizoma Imperatae 20 grams
6, Radix Rehmanniae and Radix Et Rhizoma Rhei preparation method of composition, Radix Rehmanniae are fried in shallow oil water and are concentrated, and Radix Et Rhizoma Rhei powder grinds to the powder, and the Radix Rehmanniae concentrated solution is mixed with Radix Et Rhizoma Rhei, and drying is made granule.
7, according to described Radix Rehmanniae of claim 6 and Radix Et Rhizoma Rhei preparation method of composition, Radix Rehmanniae 10 grams are fried in shallow oil water and are concentrated, and Radix Et Rhizoma Rhei 6 gram powder grind to the powder, and the Radix Rehmanniae concentrated solution is mixed with Radix Et Rhizoma Rhei, and drying is made granule.
8, the application of Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae and Radix Et Rhizoma Rhei compositions are used for the carrier of food, health product, medicine as intermediate.
9, the application of described according to Claim 8 Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae and Radix Et Rhizoma Rhei compositions are as the carrier of soft capsule, capsule, pill, tablet, electuary, injection or other dosage form.
10, the application of described according to Claim 8 Radix Rehmanniae and Radix Et Rhizoma Rhei compositions, Radix Rehmanniae and Radix Et Rhizoma Rhei compositions can add various medicines according to various objectives, as the carrier of multiple formulations.
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| CN 200410087645 CN1634426A (en) | 2004-11-23 | 2004-11-23 | Composition of fresh rehmannia root and rhubarb horsetails and preparation method thereof |
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| CN 200410087645 CN1634426A (en) | 2004-11-23 | 2004-11-23 | Composition of fresh rehmannia root and rhubarb horsetails and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977921B (en) * | 2006-12-12 | 2010-05-12 | 南京中医药大学 | Chinese medicine preparation for treating hepatitis and anti-fulminant hepatitis, and its preparing method and use |
| CN102908409A (en) * | 2012-11-15 | 2013-02-06 | 成都乾坤动物药业有限公司 | Production process of Chinese rhubarb fine powder granules |
| WO2015082950A1 (en) * | 2013-12-02 | 2015-06-11 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| CN109820864A (en) * | 2019-04-15 | 2019-05-31 | 中山万远新药研发有限公司 | A kind of Pharmaceutical composition |
-
2004
- 2004-11-23 CN CN 200410087645 patent/CN1634426A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977921B (en) * | 2006-12-12 | 2010-05-12 | 南京中医药大学 | Chinese medicine preparation for treating hepatitis and anti-fulminant hepatitis, and its preparing method and use |
| US9095606B1 (en) | 2010-11-13 | 2015-08-04 | Sirbal Ltd. | Molecular and herbal combinations for treating psoriasis |
| CN102908409A (en) * | 2012-11-15 | 2013-02-06 | 成都乾坤动物药业有限公司 | Production process of Chinese rhubarb fine powder granules |
| WO2015082950A1 (en) * | 2013-12-02 | 2015-06-11 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| EP3498288A1 (en) * | 2013-12-02 | 2019-06-19 | Sirbal Ltd. | Herbal combinations for treatment of a skin condition |
| CN109820864A (en) * | 2019-04-15 | 2019-05-31 | 中山万远新药研发有限公司 | A kind of Pharmaceutical composition |
| CN109820864B (en) * | 2019-04-15 | 2020-02-07 | 北京澳特舒尔保健品开发有限公司 | Anti-liver cancer pharmaceutical composition |
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