CN1634376A - Compound wild chrysanthemum flower skin bacteria inhibitor and preparation method thereof - Google Patents
Compound wild chrysanthemum flower skin bacteria inhibitor and preparation method thereof Download PDFInfo
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- CN1634376A CN1634376A CN 200410081253 CN200410081253A CN1634376A CN 1634376 A CN1634376 A CN 1634376A CN 200410081253 CN200410081253 CN 200410081253 CN 200410081253 A CN200410081253 A CN 200410081253A CN 1634376 A CN1634376 A CN 1634376A
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Abstract
The invention discloses a compound wild chrysanthemum flower skin bacteria inhibitor and preparation process, wherein the preparation is prepared from 39 kinds of Chinese medicinal herbs including wild chrysanthemum flower, barberry root, Chinese honey locust, corktree bark, and stemona root radix stemonae.
Description
Technology contents: the present invention relates to a kind of Chinese medicine antibacterial and preparation method thereof, particularly a kind of compound wild chrysanthemum flower skin bacteria inhibitor and preparation method thereof.
Background technology: at present, skin bacteria inhibitor of the prior art is of a great variety, but act on single in actual use, some product curative effect is unreliable, use the back illness to recur easily, can not thoroughly effect a radical cure dermatosis, also have some skin bacteria inhibitors to add chemical agent, in the treatment dermatopathy, also can produce damage to skin, prepare multiduty skin bacteria inhibitor, can thoroughly effect a radical cure dermatopathy, again chafe not, it is the problem that the inventor studies for a long period of time, the inventor adopts the pure natural plant preparation to combine with modern science and technology according to Guizhou minority nationality Miao Ethnomedicine characteristic, develops preparation of the present invention.
Summary of the invention: the object of the present invention is to provide a kind of can treat the various skin illness, to staphylococcus aureus etc. have powerful bacteriostasis, nontoxic to human body skin, have no side effect, the compound wild chrysanthemum flower skin bacteria inhibitor of determined curative effect and preparation method thereof.
The present invention is achieved in that it is formulated by following bulk drugs: Radix Berberidis 15-25, Herba Verbenae 5-15, Galla Chinensis 5-15, Herba Plantaginis 5-15, Herba Agrimoniae 5-15, Herba Erodii 5-15, Radix Stemonae 5-15, Herba Menthae Borneolum Syntheticum 5-15, Folium Eucommiae 5-15, Radix Zanthoxyli 5-15, Fructus Gleditsia 15-25, Caulis Lonicerae 2-8, Radix Sophorae Flavescentis 10-20, Rhizoma Polygoni Cuspidati 5-15, Herba Patriniae 2-8, Flos Lonicerae 5-15, Herba Asari 2-8, Radix Angelicae Pubescentis 2-8, Spica Prunellae 2-8, Herba Leonuri 5-15, Radix Scutellariae 10-20, Cortex Phellodendri 15-25, Flos Chrysanthemi Indici 5-15, Fructus Cnidii 5-15, Herba Violae 2-8, Herba Centipedae 5-15, Nidus Vespae 5-15, Fructus Xanthii 5-15, Herba Ecliptae 5-15, Herba Taraxaci 2-8, Rhizoma Osmundae 2-8, Radix Et Rhizoma Rhei 2-8, Radix Parthenocissi Heterophyllae 2-8, Radix Aristolochiae 2-8, Herba Kalimeridis 2-8, MANYUANCHOU 5-15, collapse jorum 5-15, metronidazole 50-70, clotrimazole 1-3.
Its production stage is:
A, the chopping of Fructus Gleditsia, Nidus Vespae added 20 times of water gagings decocted 1.5 hours, filter, precipitation, A liquid is standby;
B, metronidazole, clotrimazole powder are added 95% ethanol 5000cl dissolving, B liquid is standby;
C, all the other Chinese herbal medicine choppings add 20 times of water gagings soaked after 12 hours, decocted 3 hours, filtered, and filtrate adds Tween 80, and it is standby to obtain C liquid;
D, A, C liquid are mixed, stir evenly and leave standstill 24 hours, add B liquid and merge, prepare compound wild chrysanthemum flower skin bacteria inhibitor.
The present invention compared with prior art, the scope of application is wide, it can not only treat gynecological diseases, and to tinea pedis, skin pruritus, acne, the dandruff, spend grey first-class disease that significant curative effect is all arranged, for staphylococcus aureus, escherichia coli, Candida albicans powerful bacteriostasis is arranged, non-stimulated to skin, have no side effect, the treatment skin disease is suffered from definite curative effect, detect through the disease prevention and control center, Guizhou Province, this product has stronger bacteriostasis.
Detect conclusion
1, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor stock solution pH value is 5.72 (5.68-5.74)
2, microbial contamination assay shows: censorship Guizhou Province dark board compound wild chrysanthemum flower flushing liquor is through check, and every microbiological indicator all meets GB15979-2002 " disposable use hygienic article sanitary standard ".
3, bacteriostatic test shows: under 20 ± 2 ℃ condition, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution is to staphylococcus aureus, escherichia coli, Candida albicans effect 0.5min, and average bacteriostasis rate is not for reaching 99.90% (99.80%-99.97%), 100.00% (100.00%), 98.36% (97.67%-99.03%).According to GB15979-2002 " disposable use hygienic article sanitary standard ", judge that Guizhou Province dark board compound recipe flushing liquor stock solution all has stronger bacteriostasis to each indicator bacteria.
4, stability test shows: Guizhou Province dark board compound wild chrysanthemum flower flushing liquor was placed 14 days for 54 ℃, place after 90 days for 37 ℃, stock solution is to Candida albicans effect 0.5min, average antibacterial branch is not 96.70% (96.23%-97.25%), 92.48% (89.59%-94.12%) in addition, according to GB15979-2002 " disposable use hygienic article sanitary standard ", judge that this product has stronger bacteriostasis to Candida albicans.Show that at room temperature this product can be preserved 2 years.
5, acute oral toxicity test shows: censorship Guizhou Province dark board compound wild chrysanthemum flower flushing liquor is nontoxic greater than the true border of 5000mg/kg body weight to white mice acute oral median lethal dose(LD 50) ().
6, the skin allergic reaction test shows: Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution is 0% to guinea pig skin sensitization rate, does not see that skin becomes reaction.
7, vaginal mucomembranous irritant test shows: Guizhou Province dark board compound wild chrysanthemum flower flushing liquor is 0.44 to rat vaginal mucosa irritation intensity, belongs to nonirritant.
8, the PCEMNR micronucleus test shows: Guizhou Province dark board compound wild chrysanthemum flower flushing liquor to water Os Mus marrow polychromatic erythrocyte micronucleus test micronucleus test feminine gender as a result, does not have the micronucleus effect that causes in being subjected to the amount of reagent scope.
Test item disinfectant pH value is measured
One, equipment:
1, the multiple Flos Chrysanthemi Indici flushing liquor of the dark board in Guizhou Province: active ingredient is a Chinese medicine.
2,, PH meter: upright imperial 818 type acidometers difficult to understand.
3,3mol/L, liquor kalii iodide, 0.1mol/L hydrochloric acid solution.
4, standard buffer solution (PH=4.0, PH=6.86, PH=9.18), by the Shanghai Testing Technology Study is produced.
Two, method:
PH value according to Ministry of Public Health " disinfection technology standard " 2.2.1.4 regulation in 2002 mensuration Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution.Detected temperatures is 22 ℃, and relative humidity is 53%.Duplicate detection three duplicate samples.
Three, result:
After testing, the pH value of the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor stock solution is 5.72 (5.68-5.74) (table).
Guizhou Province dark board compound wild chrysanthemum flower flushing liquor pH value measurement result
Sample sequence number stock solution pH value
1-1 5.68
1-2 5.70
2-1 5.72
2-2 5.73
3-1 5.74
3-2 5.74
Meansigma methods 5.72
Four, conclusion:
Show that through replication three duplicate samples Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution pH value is 5.72 (5.68-5.74).
Test item microbial contamination detects
One, equipment:
1, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor: active ingredient is a Chinese medicine.
2, nutrient agar.
3, husky Bao Shi agar culture medium.
4, bile salt lactose fermentation tube.
5, SCDLP culture medium.
6, dextrose bouillon.
Two, method:
1, detects foundation: GB15979-2002 " disposable use hygienic article sanitary standard " appendix B regulation.
2, testing conditions: 20 ± 2 ℃ of test temperatures, humidity are 60%, and the laboratory cleanliness factor is thousand grades.
The result:
Guizhou Province dark board compound wild chrysanthemum flower flushing liquor microbial contamination testing result
Test item measured value standard value
Total number of bacterial colonies (cfu/mL) 0≤200
Fungus colony sum (cfu/mL) 0≤100
Coliform must not detect and detected
Staphylococcus aureus must not detect and detects
Dark courageous and upright streptococcus must not detect and detects
Bacillus pyocyaneus must not detect and detects
Four, conclusion:
Censorship Guizhou Province dark board compound chrysanthemum flushing liquor total number of bacterial colonies, coliform, staphylococcus aureus, Hemolytic streptococcus, bacillus pyocyaneus, the every microbiological indicator of fungus colony sum after testing all meets the requirement of GB15979-2002 " disposable use hygienic article sanitary standard ".
Test item bacteriostatic test (staphylococcus aureus)
One, equipment:
1, experimental strain: staphylococcus aureus (ATCC6538), epidemic diseases institute of microbiology of institute of section of army provides.10-11 generation 37 ℃ of cultivations 24h Nutrient agar inclined-plane fresh cultured thing is used in test.
2, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor: active ingredient is a Chinese medicine.
3,0.03mol/L phosphate buffer (PBS PH=7.2).
4, the 0.03mol/L PBS that contains 0.1% tween 80.
5, the 0.03mol/L PBS that contains 1% peptone.
6, nutrient agar.
Two, method:
1, detects foundation: GB15979-2002 " disposable use hygienic article sanitary standard " appendix C 4.1
2, testing conditions: 20 ± 2 ℃ of test temperatures, test triplicate.
3, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor activity is a stock solution, action time for Wei not 0.5min, 1min,
1.5min, 2min.37 ℃ cultivates observed result behind the 48h.
Three, result:
Through three repeated trials, the result shows: under 20 ± 2 ℃ of conditions, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution acts on 0.5min to staphylococcus aureus, and average bacteriostasis rate reaches 99.90% (99.80%-99.97%) (seeing Table).
Table Guizhou Province dark board compound wild chrysanthemum flower flushing liquor is to the fungistatic effect of staphylococcus aureus
Test different action times of sequence number (min) are bacteriostasis rate (%) on average
0.5 1 1.5 2
1 99.80 99.96 100.00 100.00
2 99.97 100.00 100.00 100.00
3 99.94 100.00 100.00 100.00
Average 99.90 99.99 100.00 100.00
Annotate: it is 28600 (24600 ∽ 30800) cfu/ml that positive controls on average reclaims clump count; The equal asepsis growth of negative control.
Four, conclusion:
According to GB15979-2002 " disposable use hygienic article sanitary standard ", under experimental condition, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution effect 0.5min, the average bacteriostasis rate of staphylococcus aureus is reached 99.90% (99.80%-99.97%), show that Guizhou Province dark board compound wild chrysanthemum flower flushing liquor has stronger bacteriostasis to staphylococcus aureus.
Test item bacteriostatic test (escherichia coli)
One, equipment:
1, experimental strain: epidemic diseases institute of microbiology of institute of section of escherichia coli (8099) army provides, and 8-9 generation 37 ℃ of cultivations 24h Nutrient agar inclined-plane fresh cultured thing is used in test.
2, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor: active ingredient is a Chinese medicine.
3,0.03mol/L phosphate buffer (PBS PH=7.2).
4, the 0.03mol/L PBS that contains 0.1% tween 80.
5, the 0.03mol/L PBS that contains 1% peptone.
6, nutrient agar.
Two, method:
1, detects foundation: GB15979-2002 " disposable use hygienic article sanitary standard " appendix C 4.1
2, testing conditions: 20 ± 2 ℃ of test temperatures, test triplicate.
3, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor activity is a stock solution, action time for Wei not 0.5min, 1min,
1.5min, 2min.37 ℃ cultivates observed result behind the 48h.
Three, result:
Through three repeated trials, the result shows: under 20 ± 2 ℃ of conditions, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution acts on 0.5min to escherichia coli, and average bacteriostasis rate reaches 100.00% (100.00%) (seeing Table).
Table Guizhou Province dark board compound wild chrysanthemum flower flushing liquor is to colibacillary fungistatic effect
Test different action times of sequence number (min) are bacteriostasis rate (%) on average
0.5 1 1.5 2
1 100.00 100.00 100.00 100.00
2 100.00 100.00 100.00 100.00
3 100.00 100.00 100.00 100.00
Average 100.00 100.00 100.00 100.00
Annotate: the thin average recovery clump count of positive control is 58267 (39000 ∽ 68800) cfu/ml; The equal asepsis growth of negative control.
Four, conclusion:
According to GB15979-2002 " disposable use hygienic article sanitary standard ", under experimental condition, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution acts on 0.5min to escherichia coli, average bacteriostasis rate reaches 100% (100%), shows that Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution has stronger bacteriostasis to escherichia coli.
Test item bacteriostatic test (Candida albicans)
One, equipment:
1, experimental strain: epidemic diseases institute of microbiology of institute of section of Candida albicans (ATCC10231) army provides, and the husky Bao Shi agar slant of 5-6 generation 37 ℃ of cultivations 24h fresh cultured thing is used in test.
2, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor: active ingredient is a Chinese medicine.
3,0.03mol/L phosphate buffer (PBS PH=7.2).
4, the 0.03mol/L PBS that contains 0.1% tween 80.
5, the 0.03mol/L PBS that contains 1% peptone.
6, husky Bao Shi agar culture medium.
Two, method:
1, detects foundation: GB15979-2002 " disposable use hygienic article sanitary standard " appendix C 4.1
2, testing conditions: 20 ± 2 ℃ of test temperatures, test triplicate.
3, the dark board compound wild chrysanthemum flower in Guizhou Province flushing liquor activity is a stock solution, action time for Wei not 0.5min, 1min,
1.5min, 2min.37 ℃ cultivates observed result behind the 72h.
Three, result:
Through three repeated trials, the result shows: under 20 ± 2 ℃ of conditions, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution is to effect 0.5min, and average bacteriostasis rate reaches 98.36% (97.67%-99.03%) (seeing Table).
Table Guizhou Province dark board compound wild chrysanthemum flower flushing liquor is to the oidiomycetic fungistatic effect of white
Test different action times of sequence number (min) are bacteriostasis rate (%) on average
0.5 1 1.5 2
1 99.03 100.00 100.00 100.00
2 97.67 100.00 100.00 100.00
3 98.26 100.00 100.00 100.00
Average 98.36 100.00 100.00 100.00
Annotate: it is 53933 (44200 ∽ 63800) cfu/ml that positive controls on average reclaims clump count; Negative control is equal
Four, conclusion:
According to GB15979-2002 " disposable use hygienic article sanitary standard ", under experimental condition, Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution effect 0.5min, the average bacteriostasis rate of Candida albicans is reached 98.36% (97.67%-99.03%), show that Guizhou Province dark board compound wild chrysanthemum flower flushing liquor stock solution has stronger bacteriostasis to Candida albicans.
Model case
Luo Xiaoqin, the woman, 35 years old, suffer from gynaecopathia for a long time, once used multiple Gynecological health washing liquid, effect is all undesirable, gynecological inflammation often recurs, use compound wild chrysanthemum flower skin bacteria inhibitor certainly after, effect is fine, gynecological inflammation is also thoroughly effected a radical cure.
Tang Shiqun, the woman, 43 years old, this patient's biped was suffered from tinea pedis companion eczema for many years, used the medicine of multiple this disease of treatment, but produced little effect,, spray foot every day twice through using compound wild chrysanthemum flower skin bacteria inhibitor, after using for two weeks continuously, disease disappears, and it is smooth that skin also becomes.
Jiang Jianhua, the woman, 58 years old, this patient's both feet toe was suffered from grey first disease more than 20 year, successively used several medicines for the treatment of grey first disease all not see curative effect, through using compound wild chrysanthemum flower skin bacteria inhibitor, embrocate the affected part, every day 2 times, used for three weeks continuously after, existing diseased region is replaced by newborn healthy toenail gradually.
Wu Xiaodi, the man, 23 years old, because of face was suffered from the folliculitis acne more than 2 years, the multiple ointment that the nuzzles up commentaries on classics of not getting better through using compound wild chrysanthemum flower skin bacteria inhibitor, is embrocated face, every day 2 times, use continuously after 1 month, acne disappear, and face does not have any cicatrix, not recurrence so far.
The specific embodiment:
Embodiment 1: takes by weighing Fructus Gleditsia 15g, Nidus Vespae 5g chopping and adds 20 times of water gagings decoctions 1.5 hours, filter, and precipitation, it is standby to get A liquid;
Metronidazole 50g, clotrimazole 1g powder are added 95% ethanol 5000cl dissolving, and it is standby to get B liquid;
With Radix Berberidis 15g, Herba Verbenae 5g, Galla Chinensis 5g, Herba Plantaginis 5g, Herba Agrimoniae 5g, Herba Erodii 5g, Radix Stemonae 5g, Herba Menthae Borneolum Syntheticum 5g, Folium Eucommiae 5g, Radix Zanthoxyli 5g, Caulis Lonicerae 2g, Radix Sophorae Flavescentis 10g, Rhizoma Polygoni Cuspidati 5g, Herba Patriniae 2g, Flos Lonicerae 5g, Herba Asari 2g, Radix Angelicae Pubescentis 2g, Spica Prunellae 2g, Herba Leonuri 5g, Radix Scutellariae 10g, Cortex Phellodendri 15g, Flos Chrysanthemi Indici 5g, Fructus Cnidii 5g, Herba Violae 2g, Herba Centipedae 5g, Fructus Xanthii 5g, Herba Ecliptae 5g, Herba Taraxaci 2g, Rhizoma Osmundae 2g, Radix Et Rhizoma Rhei 2g, Radix Parthenocissi Heterophyllae 2g, Radix Aristolochiae 2g, Herba Kalimeridis 2g, MANYUANCHOU 5g, collapse jorum 5g chopping and add 20 times of water gagings immersions after 12 hours, decocted 3 hours, filter, filtrate adds Tween 80, and it is standby to obtain C liquid;
A, C liquid are mixed, stir evenly and leave standstill 24 hours, add B liquid and merge, prepare compound wild chrysanthemum flower skin bacteria inhibitor.
Embodiment 2: takes by weighing Fructus Gleditsia 25g, Nidus Vespae 15g chopping and adds 20 times of water gagings decoctions 1.5 hours, filter, and precipitation, it is standby to get A liquid;
Metronidazole 70g, clotrimazole 3g powder are added 95% ethanol 5000cl dissolving, and it is standby to get B liquid;
With Radix Berberidis 25g, Herba Verbenae 15g, Galla Chinensis 15g, Herba Plantaginis 15g, Herba Agrimoniae 15g, Herba Erodii 15g, Radix Stemonae 15g, Herba Menthae Borneolum Syntheticum 15g, Folium Eucommiae 15g, Radix Zanthoxyli 15g, Caulis Lonicerae 8g, Radix Sophorae Flavescentis 20g, Rhizoma Polygoni Cuspidati 15g, Herba Patriniae 8g, Flos Lonicerae 15g, Herba Asari 8g, Radix Angelicae Pubescentis 8g, Spica Prunellae 8g, Herba Leonuri 15g, Radix Scutellariae 20g, Cortex Phellodendri 25g, Flos Chrysanthemi Indici 15g, Fructus Cnidii 15g, Herba Violae 8g, Herba Centipedae 15g, Fructus Xanthii 15g, Herba Ecliptae 15g, Herba Taraxaci 8g, Rhizoma Osmundae 8g, Radix Et Rhizoma Rhei 8g, Radix Parthenocissi Heterophyllae 8g, Radix Aristolochiae 8g, Herba Kalimeridis 8g, MANYUANCHOU 15g, collapse jorum 15g chopping and add 20 times of water gagings immersions after 12 hours, decocted 3 hours, filter, filtrate adds Tween 80, and it is standby to obtain C liquid;
A, C liquid are mixed, stir evenly and leave standstill 24 hours, add B liquid and merge, prepare compound wild chrysanthemum flower skin bacteria inhibitor.
Claims (2)
1, a kind of compound wild chrysanthemum flower skin bacteria inhibitor is characterized in that: formulated by following bulk drugs: Radix Berberidis 15-25, Herba Verbenae 5-15, Galla Chinensis 5-15, Herba Plantaginis 5-15, Herba Agrimoniae 5-15, Herba Erodii 5-15, Radix Stemonae 5-15, Herba Menthae Borneolum Syntheticum 5-15, Folium Eucommiae 5-15, Radix Zanthoxyli 5-15, Fructus Gleditsia 15-25, Caulis Lonicerae 2-8, Radix Sophorae Flavescentis 10-20, Rhizoma Polygoni Cuspidati 5-15, Herba Patriniae 2-8, Flos Lonicerae 5-15, Herba Asari 2-8, Radix Angelicae Pubescentis 2-8, Spica Prunellae 2-8, Herba Leonuri 5-15, Radix Scutellariae 10-20, Cortex Phellodendri 15-25, Flos Chrysanthemi Indici 5-15, Fructus Cnidii 5-15, Herba Violae 2-8, Herba Centipedae 5-15, Nidus Vespae 5-15, Fructus Xanthii 5-15, Herba Ecliptae 5-15, Herba Taraxaci 2-8, Rhizoma Osmundae 2-8, Radix Et Rhizoma Rhei 2-8, Radix Parthenocissi Heterophyllae 2-8, Radix Aristolochiae 2-8, Herba Kalimeridis 2-8, MANYUANCHOU 5-15, collapse jorum 5-15, metronidazole 50-70, clotrimazole 1-3.
2, according to the preparation method of a kind of compound wild chrysanthemum flower skin bacteria inhibitor of claim 1, it is characterized in that: production stage is
A, the chopping of Fructus Gleditsia, Nidus Vespae added 20 times of water gagings decocted 1.5 hours, filter, precipitation, A liquid is standby;
B, metronidazole, clotrimazole powder are added 95% ethanol 5000cl dissolving, B liquid is standby;
C, all the other Chinese herbal medicine choppings add 20 times of water gagings soaked after 12 hours, decocted 3 hours, filtered, and filtrate adds Tween 80, and it is standby to obtain C liquid;
D, A, C liquid are mixed, stir evenly and leave standstill 24 hours, add B liquid and merge, prepare compound wild chrysanthemum flower skin bacteria inhibitor.
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