CN1631365A - Sodium salinomycin powder and its preparation - Google Patents
Sodium salinomycin powder and its preparation Download PDFInfo
- Publication number
- CN1631365A CN1631365A CN 200410023920 CN200410023920A CN1631365A CN 1631365 A CN1631365 A CN 1631365A CN 200410023920 CN200410023920 CN 200410023920 CN 200410023920 A CN200410023920 A CN 200410023920A CN 1631365 A CN1631365 A CN 1631365A
- Authority
- CN
- China
- Prior art keywords
- salinomycin
- sodium
- granule
- salinomycin sodium
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Fodder In General (AREA)
Abstract
Disclosed is a sodium salinomycin powder and its preparation, which comprises the steps of fermentation liquor acidification and deactivation, sedimentation and concentrating, adjusting pH, charging adjuvant and medicinal bonding agent, charging bottom flavoring into fluid bed hopper, spray drying, spraying dried particles, mixing and sieving. The bonding agent can be alpha-starch, carboxymethy Icellulose sodium and carboxymethyl cellulose sodium.
Description
Technical field: the present invention relates to antibiotic and preparation method thereof, relate in particular to Salinomycin Sodium granule and preparation method thereof.
Background technology: the Salinomycin manufacturing technology of prior art has solvent extraction, is the Salinomycin that utilizes in the organic solvent extraction Salinomycin fermentation liquid, thereby obtains the Salinomycin sodium pure product.Chinese patent ZL93115177.5 discloses the fermentation liquid seasoning and has extracted Salinomycin, is to add adjuvant to carry out spray drying in the Salinomycin fermentation liquid, makes pulverous feed grade Salinomycin.Chinese patent ZL98106302.0 has proposed fermentation liquid filtration cakes torrefaction legal system and has got Salinomycin, is to add filter aid in the Salinomycin fermentation liquid, obtains filter cake with the pressure filter filter pressing, with filtration cakes torrefaction, obtains the feed grade Salinomycin.But the feed grade Salinomycin that these methods make all is Powdered, producing and adding in the feedstuff process, very easily produces a large amount of dust because the Salinomycin particle diameter is little, influences operator's health, contaminated environment.
Summary of the invention: the objective of the invention is to, overcome the deficiencies in the prior art part, a kind of Salinomycin Sodium granule and preparation method thereof is provided, overcome produce and with feedstuff mixed process in produce the defective of a large amount of dust, and can guarantee and the feedstuff mix homogeneously.Salinomycin Sodium granule of the present invention and preparation method thereof includes fermentation liquid acidify deactivation, sedimentation and concentrates, adds adjuvant and medicinal adhesive, adjusts and add bed material, spray-drying process, mixing screening Salinomycin Sodium granule in pH value, the fluid bed and form.Said fermentation liquid acidify deactivation is after making fermentation liquid through fermentation technology, the fermentation liquid acidify deactivation operation of carrying out.Add in the fluid bed in the bed material, said bed material is one or more a mixture wherein such as the Semen Maydis powder by 60 eye mesh screens, analysis for soybean powder, peanut cake powder, soybean cake powder, perlite, kieselguhr, zeolite fully.Said medicinal adhesive be alphalise starch, Carboxymethyl cellulose sodium and sodium carboxymethyl cellulose, carboxymethylstach sodium, hyprolose etc. wherein one or more.The spray-drying process process is meant that the Salinomycin fermentation liquid after deactivation, sedimentation concentration adds adjuvant and medicinal adhesive in proportion, and adjusting pH value is alkalescence, implements the bed spray drying process, dry with bed material, makes the Salinomycin Sodium granule.Mix back screening Salinomycin Sodium and spray dried granule; the process that the Salinomycin Sodium granule mixes screening is; Salinomycin Sodium granule mix homogeneously with different batches, content; then through No. 2 sieves and No. 5 sieve sieving separating, get particle diameter wherein between No. 2 sieves and the granule between sieving for No. 5 promptly obtain Salinomycin Sodium granule of the present invention.The Salinomycin Sodium granule of indication, No. 2 oversizes and No. 5 siftage all are less than or equal to 5.0%.
Use Salinomycin Sodium process for producing granula of the present invention, the Salinomycin Sodium granule of producing, its No. 2 oversizes and No. 5 siftage all are less than or equal to 5.0%, have to be not easy to form dust, and can guarantee and the mixed uniformly advantage of feedstuff.
Description of drawings: accompanying drawing is the process chart of Salinomycin Sodium granule of the present invention and preparation method thereof.1-fermentation liquid 2-acid 3-alkali 4-adjuvant and medicinal adhesive 5-bed material 6-spray drying 7-mixing Salinomycin Sodium granule 8-shaking screen screening 9-Salinomycin Sodium granule
The specific embodiment: referring now to accompanying drawing, be described in detail as follows in conjunction with the embodiments: Salinomycin Sodium granule of the present invention and preparation method thereof, include fermentation liquid 1 and add sour 2 acidifys adjustment pH3.0-4.5, heat 50-80 ℃ of deactivation, supernatant concentration is gone in sedimentation, add adjuvant and medicinal adhesive 4, adjusting pH value with alkali 3 is to add bed material 5 in alkalescence, the fluid bed hopper, implement spray drying 6, the granule that makes is mixed by mixing Salinomycin Sodium granule 7 operations, sieve by shaking screen screening 8 then, obtain Salinomycin Sodium granule 9.Said fermentation liquid acidify deactivation sedimentation concentrates, and is after making fermentation liquid through fermentation technology, fermentation liquid acidify deactivation of carrying out and sedimentation enrichment process.The concentrated solution that makes behind fermentation liquid acidify deactivation sedimentation enrichment process comes into effect adding adjuvant and medicinal adhesive 4 operations, and adjusting pH value is alkalescence, adds bed material 5 in the fluid bed, implements spray drying 6.Said bed material is one or more a mixture wherein such as the Semen Maydis powder by 60 eye mesh screens, analysis for soybean powder, peanut cake powder, soybean cake powder, perlite, kieselguhr, zeolite fully.Said medicinal adhesive is alphalise starch, Carboxymethyl cellulose sodium and sodium carboxymethyl cellulose, carboxymethylstach sodium, hyprolose etc.Salinomycin fermentation liquid after deactivation sedimentation concentration adds adjuvant and medicinal adhesive in proportion, is alkalescence through adjusting pH value, implements fluid bed and adds bed material spray drying 6 operations, makes spraying material dry with bed material, makes and mixes Salinomycin Sodium granule 7.With the Salinomycin Sodium granule mix homogeneously of different batches, content, after No. 2 screen clothes and No. 5 screen cloth screenings, promptly make Salinomycin Sodium granule 8 of the present invention.Said Salinomycin Sodium granule 8, its No. 2 oversizes and No. 5 siftage are all≤5.0%.Use the preparation method of Salinomycin Sodium granule of the present invention, produce No. 2 oversizes of particle diameter and No. 5 siftage Salinomycin Sodium granule all≤5.0%, easy to use, granule is not easy to form dust, and can guarantee and the feedstuff uniform mixing.
Embodiment 1: fermentation obtains the fermentation liquid 500L that Salinomycin unit is 25-60mg/ml, adds sulphuric acid or hydrochloric acid and adjusts pH1.0-5.5, heats 50-80 ℃ of deactivation, adds the 35kg calcium carbonate, stirs, and adjusts pH8.0-10.0 with 20%NaOH.Weighing 0.18kg alphalise starch with 50-80 ℃ of water dissolution, adds in the above-mentioned solution mix homogeneously.In the fluid bed hopper, add the 75kg Semen Maydis powder; Start fluid bed, high pressure positive blower is sent into hot-air, makes Semen Maydis powder be fluidized state; Control inlet temperature 110-160 ℃ of fluid bed, leaving air temp 60-80 ℃ spray into fluid bed with 0.40-0.60MPa pressure with fermentation liquid, stick on it behind the chance Semen Maydis powder, become granule through hot-air dry.This granule is through mixing, and is that the granularity of 122 μ g/mg is that No. two sieve oversizes and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule by obtaining after No. 2 and No. 5 sieve screenings that 140.8kg tires.
Embodiment 2: the Salinomycin fermentation liquid that obtains of fermentation through acidify, deactivation, adjustment pH value with embodiment 1.Weighing 0.18kg sodium carboxymethyl cellulose with 50-80 ℃ of water dissolution, adds in the fermentation liquid mix homogeneously.All the other operations are identical with embodiment 1.Obtaining that 152.6kg tires is that the granularity of 119 μ g/mg is that No. two sieve oversizes and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule.
Embodiment 3: the Salinomycin fermentation liquid that obtains of fermentation through acidify, deactivation, adjustment pH value with embodiment 1.Weighing 0.18kg Carboxymethyl cellulose sodium with 50 ℃ of water dissolutioies, adds in the fermentation liquid mix homogeneously.All the other operations are identical with embodiment 1.Obtaining that 152.6kg tires is 117 μ g/mg, and granularity is that No. two sieve oversizes and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule.
Embodiment 4: the Salinomycin fermentation liquid that obtains of fermentation through acidify, deactivation, adjustment pH value with embodiment 1.Weighing 0.18kg alphalise starch with 50 ℃ of water dissolutioies, adds in the fermentation liquid mix homogeneously.Add the 75kg analysis for soybean powder in the fluid bed hopper, all the other steps are with embodiment 1, and obtaining that 144.0kg tires is that the granularity No. two sieves oversize of 122 μ g/mg and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule.
Embodiment 5: the Salinomycin fermentation liquid that obtains of fermentation through acidify, deactivation, adjustment pH value, add alphalise starch with embodiment 1.Add peanut cake powder in the fluid bed hopper, all the other operations are identical with embodiment 1.Obtaining that 141.2kg tires is that No. two, the granularity sieve oversize of 125 μ g/mg and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule.
Embodiment 6: the Salinomycin fermentation liquid acidify that fermentation obtains, deactivation, adjustment pH value, adding alphalise starch are with embodiment 1.Add soybean cake powder in the fluid bed hopper, all the other operations are identical with embodiment 1.Obtaining that 146.7kg tires is that No. two, the granularity sieve oversize of 121 μ g/mg and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule.
Embodiment 7: the Salinomycin fermentation liquid acidify that fermentation obtains, deactivation, adjustment pH value, adding alphalise starch are with embodiment 1.Add perlite in the fluid bed hopper, all the other operations are identical with embodiment 1.Obtaining that 145.1kg tires is that No. two, granularity sieve oversize and No. five sieve siftage of 120 μ g/mg all are less than or equal to 5.0% Salinomycin Sodium granule.
Embodiment 8: the Salinomycin fermentation liquid acidify that fermentation obtains, deactivation, adjustment pH value, adding alphalise starch are with embodiment 1.Add zeolite in the fluid bed hopper, all the other operations are identical with embodiment 1.Obtaining that 142.6kg tires is that No. two, the granularity sieve oversize of 118 μ g/mg and No. five sieve siftage are all smaller or equal to 5.0% Salinomycin Sodium granule.
Embodiment 9: obtain the Salinomycin Sodium granule according to embodiment 1; with 50kg Salinomycin Sodium content is that the Salinomycin Sodium granule of 122 μ g/mg and Salinomycin Sodium granule that 50kg Salinomycin Sodium content is 118 μ g/mg mix, and obtains 100kg Salinomycin Sodium content and be 120 μ g/mg granularities No. two sieves oversize and No. five sieve siftage all smaller or equal to 5.0% Salinomycin Sodium granule.
Claims (2)
1, Salinomycin Sodium granule, its preparation method includes fermentation liquid (1) acidify deactivation, adding adjuvant and medicinal adhesive (4), adjusts pH value is that the screening Salinomycin Sodium sprays dried granule and Salinomycin Sodium granule (8) composition after adding bed material (5), spray drying (6), mixing in alkalescence, the fluid bed hopper, it is characterized in that said adhesive is alphalise starch, Carboxymethyl cellulose sodium and sodium carboxymethyl cellulose; Said bed material is one or more a mixture wherein such as the Semen Maydis powder by 60 eye mesh screens, analysis for soybean powder, peanut cake powder, soybean cake powder, perlite, kieselguhr, zeolite fully; Said Salinomycin Sodium granule be meant grain diameter more than 90% between No. 2 the sieve and No. 5 the sieve between the Salinomycin Sodium granule.
2, Salinomycin Sodium granule according to claim 1 is characterized in that said Salinomycin Sodium granule, and No. 2 oversizes and No. 5 siftage are all≤5.0%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023920 CN1631365A (en) | 2004-04-14 | 2004-04-14 | Sodium salinomycin powder and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410023920 CN1631365A (en) | 2004-04-14 | 2004-04-14 | Sodium salinomycin powder and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1631365A true CN1631365A (en) | 2005-06-29 |
Family
ID=34845694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410023920 Pending CN1631365A (en) | 2004-04-14 | 2004-04-14 | Sodium salinomycin powder and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1631365A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884621A (en) * | 2010-06-29 | 2010-11-17 | 金河生物科技股份有限公司 | Method for preparing salinomycin particle premix |
| CN104546739A (en) * | 2015-01-20 | 2015-04-29 | 山西新源华康化工股份有限公司 | Extraction process of salinomycin |
| CN108309953A (en) * | 2018-03-30 | 2018-07-24 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
| CN108420796A (en) * | 2018-03-30 | 2018-08-21 | 内蒙古拜克生物有限公司 | A kind of salinomycin particle premix and preparation method thereof |
| CN108743544A (en) * | 2018-03-30 | 2018-11-06 | 内蒙古拜克生物有限公司 | A kind of production method of high-content salinomycin pre-mixing agent |
-
2004
- 2004-04-14 CN CN 200410023920 patent/CN1631365A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884621A (en) * | 2010-06-29 | 2010-11-17 | 金河生物科技股份有限公司 | Method for preparing salinomycin particle premix |
| CN101884621B (en) * | 2010-06-29 | 2012-04-18 | 金河生物科技股份有限公司 | Method for preparing salinomycin particle premix |
| CN104546739A (en) * | 2015-01-20 | 2015-04-29 | 山西新源华康化工股份有限公司 | Extraction process of salinomycin |
| CN108309953A (en) * | 2018-03-30 | 2018-07-24 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
| CN108420796A (en) * | 2018-03-30 | 2018-08-21 | 内蒙古拜克生物有限公司 | A kind of salinomycin particle premix and preparation method thereof |
| CN108743544A (en) * | 2018-03-30 | 2018-11-06 | 内蒙古拜克生物有限公司 | A kind of production method of high-content salinomycin pre-mixing agent |
| CN108309953B (en) * | 2018-03-30 | 2019-02-26 | 内蒙古拜克生物有限公司 | A kind of production method of salinomycin microcapsule granule |
| CN108743544B (en) * | 2018-03-30 | 2019-08-16 | 内蒙古拜克生物有限公司 | A kind of production method of high-content salinomycin pre-mixing agent |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105110819B (en) | A method of sulfenyl urea compound fertilizer is produced using ammonia process of desulfurization by-product | |
| CN104351483A (en) | Preparation method of completely fermented oxytetracycline calcium granules | |
| CN107149926B (en) | Preparation method of attapulgite vomitoxin adsorbent | |
| CN1062421C (en) | Process for the preparation of protein-rich product from brewer's spent grain | |
| CN110913980A (en) | Mixture of granular polyhalite and potash and production process thereof | |
| CN103536585B (en) | A kind of squeezing and pressing method produces the method for instant branched-chain amino acid | |
| CN1631365A (en) | Sodium salinomycin powder and its preparation | |
| CN101428827A (en) | Method for producing ultrafine-grain special mirabilite | |
| CN102599508A (en) | Preparation for preparing chondroitin glucosamine particles by wet method and preparation method | |
| CN103820583A (en) | Preparation method for granulose condensable sugar | |
| CN101265487A (en) | Preparation method for enriching gamma-aminobutyric acid by using fixed rice bran glutamic acid decarboxylase | |
| CN101390840B (en) | Production method of high-assay calcium ascorbate granules capable of directly being compressed | |
| CN103110515A (en) | Glucosamine potassium sulfate particle production method | |
| CN104131001A (en) | Preparation method for granular and solid powdery enzyme preparation | |
| CN111712321A (en) | Potassium dust pelletizing process | |
| CN103110588A (en) | Production method of vitamin B6 granules | |
| CN108048447A (en) | A kind of preparation method of enzyme preparation | |
| US10479691B2 (en) | Method for recovering silica from silica-containing plant body using titanium oxide | |
| JPH07227300A (en) | Muscovado-containing powder and its production | |
| JP6625187B1 (en) | Method for producing granulated material of wheat sprouts dry powder | |
| JPH0725622B2 (en) | Method for producing organic matter-containing fertilizer | |
| CN101669614A (en) | Non-animal derived high-nitrogen powdered chicken essence | |
| CN104621360A (en) | Preparation method of bacitracin zinc premix | |
| CN1562061A (en) | Tylan phosphate granular agent and its preparing method | |
| CN1562066A (en) | Tylan tartrate grunular preparation and its preparating method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |