CN1621104A - Meridian point therapeutic plaster of high polymer multi hole energy gathering ion and its preparation method and application - Google Patents
Meridian point therapeutic plaster of high polymer multi hole energy gathering ion and its preparation method and application Download PDFInfo
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Abstract
The meridian point treating plaster includes outer medical pressure-sensitive glue layer, middle meridian point treating layer and inside protecting layer, and features that between the pressure-sensitive glue layer and the meridian point treating layer, there are directional potential homogenizing layer and energy focusing ion layer. The present invention has the advantage of combining the energy focusing ion film and meridian point treating layer with medicine component to result in high synergistic transdermal treating effect. The present invention acts the combined effects of acupoint moxibution, medicine, static electric field and micro current onto the meridian point system to reach the functions of dredging meridian, promoting blood circulation to disperse blood clots, relieving pain, raising immunity, etc. The present invention may be used in treating various diseases clinically.
Description
Technical field
The present invention relates to a kind of medical Polymer Porous Power-assembling Ion Jing Point Treatment Stick, have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, analgesia detumescence, regulate human-body viscera function, correct the effect of pathology disturbance state.Can be used for treating thrombosis class and vascular endothelial injury class disease and the low all kinds of diseases of immunity of organisms such as osteoarthritis, rheumatism atrophic arthritis, hyperosteogeny, cyclomastopathy, pelvic inflammatory disease, relaxing tumor pain, vasculitis, varicosis.
Background technology
Extremely catch people's attention with its unfailing over the past thousands of years curative effect glamour as one of Traditional Chinese Medicine important component part through the cave transdermal treatments, do not wane though exceed thousand.In order to strengthen its transdermal curative effect and to enlarge therapeutic domain, in recent years, Chinese scholars has been done a large amount of fruitful researchs to iontophoresis acupuncture point skin-penetrating therapeutic, but these acupuncture point moxibustion transdermal systems all need additional power source and conductive electrode, or utilize electronic machine and exothermic material to heat, heat, or the heat energy and the penetration power of utilization far infrared, heat to medicine, play the effect of transdermal moxibustion in the acupuncture point with medicine and warm combined effect, inconvenience is arranged, unfavorable popularization more in the application.
Along with subject development such as functional material, biomedical engineering and medical science with interpenetrate, the high molecular polymer electret membrane progressively is applied to clinical with its excellent biological compatibility as a kind of naturopathy means, the electret electron membrane made from this material can be used as the implanted human body of stimulus or sticks in skin or fracture, damage part, treats by electrostatic field and little electric current that electret produces.The project of national nature science fund project experimental result shows: the negative polarity electret has the growth of the 3T3 of promotion cell and induces the apoptotic double regulation control effect of 3T3.The mechanism of electret cell death inducing is: the negative polarity electret has changed the transmembrane potential of cell, make the Cytoplasm flow of calcium ions, causing intracellular calcium concentration to occur persistence rapidly raises, calcium is as courier's medium in the cell or promote the endonuclease enzyme activation, degradation of dna is the fragment of 180~200bp, causes apoptosis.Experiment confirm: electret membrane is long-term, continue and stable electric field action has dual regulation to blood capillary, can microcirculation improvement, promote cell differentiation.Electret membrane can reduce the plasma viscosity of laboratory animal, whole blood viscosity and packed cell volume, and erythrocytic deformation performance and aggregation extent are improved.This is because electret membrane has constant electrostatic field, in respective organization, form certain potential gradient when acting on biological tissue, increased the carried charge of visible component in blood vessel and the blood, increased between the erythrocyte and the electrostatic force of erythrocyte and surrounding tissue, improve the blood supply condition, reduce since damage cause such as blood vessel, blood etc. are organized the degree of injury of electret state, reduce erythrocytic aggregation extent.On the other hand, the electrostatic energy that electret membrane produces influences the biochemical change of cellular environment, the growth of pair cell has facilitation, can stimulate the pluripotent cell differentiation, increase the content of DNA in the unit organization, help histiocytic reparation, the electricity irritation of electret membrane forms mechanism and comes across cellular level, thereby electret membrane can play certain repair to the damage of blood vessel endothelium, thereby reduced hematoblastic attached wall amount; The gathering of visible component such as erythrocyte, platelet and packed cell volume and blood viscosity.But the film formed electricity irritation of the electret cAMP system in the active cell also in addition, this improves erythrocytic gathering and deformation performance and has the certain significance blood viscosity lowering.
CN 85100859 A disclose three kinds of high polymer microcellular electret phantoms and manufacture method, this invention has three kinds of micropore electret membrane, be politef micropore mould, polypropylene superfine fiber film, nitrocellulose microporous membrane, its common feature all has micropore can keep certain high electrostatic potential for a long time.
CN 86102516 A disclose a kind of manufacture method of polymer film electret, it is to adopt radio frequency low temperature plasma injection technology, the two sides of resulting polymer film electret is essentially nagative potential, slower with the surface electrostatic potential decay after human body skin contacts, can be used to treatment fracture and accelerated bone growth.
CN 93112427 A disclose a kind of spur film, and it belongs to a kind of external application type medical high polymer electret membrane.Adopt fluoro-containing macromolecule material to make thin film, stretched and electric charge injects the electret membrane that process combined obtains the positively charged position, can be used to treat bony spur, cervical spondylosis, the diseases such as articular degeneration of scapulohumeral periarthritis and partes corporis humani position.
CN 02136852 A discloses a kind of new purposes of polymer film electret, is used for the treatment of various disease of hyperplasia of mammary glands glands.
CN 02111071 A discloses a kind of osteotrauma healing membrane material processing method that is used for.
Application number is that 97200601 Chinese utility application discloses a kind of electret composite membrane that is fixed in skin.
Application number is that 00228776.5 Chinese utility application discloses a kind of Anti-inflammatory and analgesic adhesive plaster, and it is made up of adhered layer, metal foil layer, ion accumulation horizon, metal foil layer, face holder layer successively.Do not contain medicine, easy to use, safe, have no side effect, no skin irritation and allergic phenomena have tangible pain relieving, detumescence, antiinflammation.
Application number is the preparation method that 200310107927.7 Chinese invention patent application discloses a kind of politef electret multi-hole filtering film.
Multiple medical high polymer polymer electret film and preparation method thereof is disclosed in the prior art, but the application of known medical high polymer polymer electret film all is directly to stick in skin or fracture, damage with electret membrane to be applied topically to treatment, not and pharmaceutical compositions make with through the cave or the skin-penetrating therapeutic subsides cooperatively interact, thereby its therapeutic domain is restricted, and therapeutic effect is not ideal.Present pastes as there not being the short saturating and iontophoresis of electricity such as additional power source or exothermic material or far infrared heat energy, heat, laser through the cave skin-penetrating therapeutic, and also difficulty reaches ideal therapeutic effect.The present invention releases and a kind ofly integrates acupuncture point moxibustion and medicine, electrostatic field and little electric current combined effect in the Polymer Porous Power-assembling Ion Jing Point Treatment Stick at acupuncture point, do not need external electric, heat, far infrared plasma to import during treatment or short saturating equipment, very convenient, be beneficial to and apply.
Summary of the invention
Technical problem to be solved by this invention provides a kind of Polymer Porous Power-assembling Ion Jing Point Treatment Stick, and it is with the high polymer electret membrane and contain pasting through cave treatment of ingredient and combine use, has better therapeutic effect by the two synergism.
Technical problem to be solved by this invention also is to provide the prescription and the application thereof of above-mentioned Polymer Porous Power-assembling Ion Jing Point Treatment Stick.
Technical problem to be solved by this invention is achieved through the following technical solutions.
The invention provides a kind of Polymer Porous Power-assembling Ion Jing Point Treatment Stick; it comprises the medical pressure-sensing glue-line in the outside, intermediary protective layer through cave treatment paste layer and inboard; be provided with directed even current potential body layer and energy gathering ion layer at described medical pressure-sensing glue-line and between cave treatment paste layer, wherein directed even current potential body layer is adjacent with the medical pressure-sensing glue-line.
Described medical pressure-sensing glue-line is by polymer matrix and non-weaving cloth is compound makes, and plays fixing even current potential body layer and energy gathering ion layer.
The base material of the even current potential body layer of described orientation is made by metal material, as platinum foil.
Described energy gathering ion layer is made by the high polymer material of having positive charge or negative charge stationed.Described high polymer is a kind of porous polymer material of realizing by simple tension with long term storage electric charge ability, preferred fluoro containing polymers polymer, more preferably politef.The fluoro containing polymers polymer has the ability of long term storage electric charge, even under high humidity environment, the time of store charge is still very long.By corona discharge or by plasma technology it is carried out the high-pressure electrostatic electret, behind electret, can produce the constant high pressure electrostatic field, the space charge of these injections can be deposited on the nearly surface of high polymer material, also can be deposited on the inside of high polymer material, becomes a kind of cumulative attitude electret membrane.
Described through cave treatment paste layer specifically by pasting through the cave and skin-penetrating therapeutic pastes that two parts are compound to be made, wherein paste and skin-penetrating therapeutic pastes the placement that superposes, and fixed order arranged when stacking, the nearly protective layer that reclines through the cave, the skin-penetrating therapeutic nearly energy gathering ion layer that reclines through the cave.Paste through the cave and to make by combine with polymer matrix through cave curative effect agonist, the skin-penetrating therapeutic subsides then are that the transdermal therapeutic agent by the extract drugs in the prescription for the treatment of various disease combines with polymer matrix and makes.The multiple action that stimulates through cave propagated sensation along channel, enhancing human body immunity power and the treatment of promotion drug transdermal is brought into play in the effect that is attached to the energy gathering ion layer through the cave down.Skin-penetrating therapeutic is attached to the short saturating effect that pathology disturbance state, adjusting human-body viscera function are subsided a swelling, corrected in performance blood circulation promoting and blood stasis dispelling, analgesia under the effect of oozing of urging of medicine of energy gathering ion layer, is used for the treatment of various corresponding diseases.
Concrete through cave subsides and skin-penetrating therapeutic plaster formula is:
1, fill a prescription through cave curative effect agonist: strychnine 2.5-8 part, Toadpoison Medicine 0.5-4 part, Borneolum Syntheticum 5-10 part, cinnamic acid 5-10 part, Folium Fructus Broussonetiae 15-30 part, Rhizoma Pinelliae 5-30 part, Rhizoma Kaempferiae 5-20 part, Fructus Capsici 5-30 part, all in weight portion.
2, skin-penetrating therapeutic plaster formula:
(1) osteoarthritis skin-penetrating therapeutic plaster formula: Radix Clematidis 5-15 part, stir-fry Fructus Foeniculi 1-10 part, Rhizoma Zingiberis 1-10 part, Cortex Cinnamomi 1-10 part, Rhizoma Drynariae 1-15 part, Pyritum (calcined) 1-3 part, Radix Et Rhizoma Nardostachyos 1-5 part, Sanguis Draxonis 1-2 part, Venenum Bufonis 0.5-1 part, Flos Campsis 1-10 part, Semen Momordicae 1-10 part, Saussurea laniceps 1-10 part, Fructus Evodiae 0.5-3 part, Squama Manis 1-10 part, Herba Pyrolae 5-15 part, Folium Artemisiae Argyi 5-10 part, Radix Aconiti 1-3 part, Radix Aconiti Kusnezoffii 1-3 part, Flos Caryophylli 0.5-3 part, all in weight portion;
(2) breast disease skin-penetrating therapeutic plaster formula: Fructus Trichosanthis 5-15 part, Semen Impatientis 5-15 part, Radix Scutellariae 5-10 part, Fructus Toosendan 10-15 part, Herba Epimedii 5-15 part, Rhizoma Corydalis 5-10 part, Radix Curcumae 5-10 part, Radix Rhapontici 5-10 part, rhizoma sparganic 5-10 part, Rhizoma Curcumae 5-10 part, Radix Linderae 5-10 part, all in weight portion;
(3) gynecological inflammation skin-penetrating therapeutic plaster formula: Herba Verbenae 5-15 part, Radix Scutellariae 5-15 part, Fructus Gardeniae 5-15 part, Pericarpium Zanthoxyli 3-10 part, Rhizoma Belamcandae 5-15 part, Fructus Piperis Longi 5-15 part, Herba Houttuyniae 5-15 part, Ramulus Cinnamomi 10-15 part, Rhizoma Smilacis Glabrae 5-15 part, Realgar 0.5-1 part, Flos Rosae Rugosae 1-5 part, Spina Gleditsiae 1-10 part, all in weight portion;
(4) vasculitis, varicosis skin-penetrating therapeutic plaster formula: Lignum Sappan 5-10 part, Natrii Sulfas 5-10 part, Lignum Pini Nodi 1-5 part, Radix Aconiti 1-5 part, Radix Aconiti Kusnezoffii 1-5 part, Radix Ilicis Pubescentis 10-15 part, Fructus Forsythiae 10-15 part, Margarita powder 5-10 part, Rhizoma Paridis 5-10 part, Zaocys 5-10 part, Squama Manis 1-5 part, Spina Gleditsiae 2-5 part, Radix Achyranthis Bidentatae 2-5 part, all in weight portion;
(5) tumor skin-penetrating therapeutic plaster formula: Realgar 1-3 part, Resina garciniae 1-4 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5-15 part, Radix Kansui 0.5-3 part, Radix Arnebiae (Radix Lithospermi) 5-20 part, Herba Crotalariae sessiliflorae 1-5 part, living Hemerocallis fulva L. 5-15 part, buttercup 0.5-1 part, water tinctorius seed 5-10 part, Herba Verbenae 5-15 part, Radix aconiti szechenyiani 1-3 part, Radix Phytolaccae 1-3 part, Herba Macleayae Cordatae 5-15 part, all in weight portion.
Described protective layer is antiseized lining paper.Having protection pastes not contaminated and prevents the effect of the improper loss of energy gathering ion membrane charge through cave treatment.
Referring to Fig. 1 and Fig. 2, Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention comprises from the outside to inboard (contacting a side with human body) compound successively medical pressure-sensing glue-line 1, directed even current potential body layer 2, energy gathering ion layer 3, through cave treatment paste layer 4 and protective layer 5.
The present invention also provides the preparation method of above-mentioned Polymer Porous Power-assembling Ion Jing Point Treatment Stick, and this method comprises:
(1) will form perforated membrane through uniaxial tension as the polymer film of politef with certain connectedness, thickness 10-80 μ m, aperture 0.25-5 μ m, degree of drawing 50-70%, strike out the rectangle paster of different size then, and it is sticked in the medical pressure-sensitive adhesive patch that is lined with metal level (as aluminium foil), with corona discharge method or plasma method its paster is carried out the high pressure electret, make the energy gathering ion paster; Wherein, to the high pressure electret of its paster, the requirement according to various disease treatment mechanism can be the negative polarity electret; Also can be the positive polarity electret.
(2), be mixed and made into through the cave with polymer matrix and paste by the fluid extract of making through cave curative effect agonist prescription; To extract the transdermal therapeutic agent (fluid extract) that is prepared from according to the Chinese medicine composition of various disease prescription respectively and be mixed and made into the skin-penetrating therapeutic subsides with polymer matrix; To paste through the cave and skin-penetrating therapeutic paste superpose by fixed order (the nearly protective layer that reclines through the cave, skin-penetrating therapeutic recline nearly energy gathering ion layer) after, paste on the paster of step (1), protective mulch gets final product again.
The using method of Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention: throw off protective layer during use, stick the corresponding acupoints place according to various disease, paste every day 2~3, and every subsides can be used 24 hours continuously.
Energy gathering ion layer of the present invention is " electret " of having polarization charge stationed, it be a kind of can long term storage electric charge and (or) keep the high polymer functional material with biocompatibility of polarized state, utilize its electrostatic field and little electric current to the transdermal enhancing effect of medicine and with synergism through the cave effect, the region of interest of long stimulus human body or relevant acupuncture point make its Physiology and biochemistry effect and more positive through cave biological amplification effect.The ion channel of its scalable skin changes the acupuncture point and pastes the ionic dynamic law of Chinese medicine polarity, strengthens the Transdermal absorption of medicine.The transdermal test in vitro experimental result of Polymer Porous Power-assembling Ion Jing Point Treatment Stick shows: compare with acupuncture point subsides matched group with single, combination is pasted at negative polarity electron ion film and acupuncture point, its strychnine transdermal accumulation infiltration capacity (μ g/ml) is obviously increased, strychnine transdermal accumulation infiltration capacity at 8h period Polymer Porous Power-assembling Ion Jing Point Treatment Stick is single 1.73 times with acupuncture point subsides matched group, and this explanation Polymer Porous Power-assembling Ion Jing Point Treatment Stick has the effect that changes the short drug transdermal diffusion of skin texture.Experiment and clinical data show both at home and abroad, and physical agents such as extra electric field, little electric current perhaps act on relevant acupuncture point and can produce biological or biochemical effect the direct effect of body local organ, can be used for treating some disease.Polymer Porous Power-assembling Ion Jing Point Treatment Stick is with its electrostatic field and little electric current and synergism through the cave effect, and the region of interest of long stimulus human body or relevant acupuncture point make its physiological effect and more positive through cave biological amplification effect.The modern Chinese medicine theory is thought, the inline internal organs of meridians, outer network podomere; The acupuncture point is the moving point or the sensitive spot of organism electric field, and meridians then are the passages of organism electromagnetism conduction.There is little electric current in organism itself, inside and outside the cell membrane, all there is little electric current between the cell, and the passage of surface electric current and meridians are consistent, along meridians, and the bio-impedance minimum, electrostatic field and little function of current are in the acupuncture point, realize biological magnification by meridians, bio-electric field is made a difference, thereby body is produced the treatment effect.Therefore, the design of Polymer Porous Power-assembling Ion Jing Point Treatment Stick is to integrate acupuncture point moxibustion and medicine, electrostatic field and little electric current combined effect in Jing point system, reaches dredge the meridian passage, blood circulation promoting and blood stasis dispelling, analgesia detumescence, corrects the pathology disturbance state, regulates the effect of human-body viscera function, antithrombotic, human body immunity improving power.
Prove through clinical trial, Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention is for various common diseases, has excellent curative as thrombosis classes such as osteoarthritis, rheumatism atrophic arthritis, hyperosteogeny, cyclomastopathy, pelvic inflammatory disease, relaxing tumor pain, vasculitis, varicosis and peripheral vessels class disease and the low all kinds of diseases of immunity of organisms.
Further describe the present invention below in conjunction with accompanying drawing.
Description of drawings
Fig. 1 is the cross-sectional view of Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention.
Fig. 2 is stereochemical structure (part is decomposed) sketch map of Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention.
Fig. 3 be in the test example 5 matched group and test group to the accumulation infiltration capacity curve of strychnine.
The specific embodiment
Further describe the present invention below in conjunction with embodiment.
The Polymer Porous Power-assembling Ion Jing Point Treatment Stick of embodiment 1 treatment hyperosteogeny
(1) polytetrafluoroethylene film is formed the perforated membrane with certain connectedness through uniaxial tension, strike out the rectangle paster of 6.5cm * 11.5cm specification then, and it is sticked in the medical pressure-sensitive adhesive patch of posting aluminium foil layer, with corona discharge method its paster is injected the positive polarity high-pressure electrostatic, surface electrical place value 800-2500V makes the energy gathering ion paster;
(2) preparation polymer matrix: get gelatin and add water infiltration for 10 parts, in water-bath, heat and dissolve, add 1 part of polyvinyl alcohol, 20 parts of glycerol, 2 parts of methylcellulose, 8 parts of mixings of Tween 80 then, add 15 parts of zinc oxide, 3 parts of polyvinylpyrrolidones, kaolin again and be mixed and made into polymer matrix for 15 parts.
(3) preparation is through cave curative effect agonist: get Folium Fructus Broussonetiae 20g, Rhizoma Pinelliae 20g, Rhizoma Kaempferiae 20g, Fructus Capsici 10g are ground into coarse powder, twice (the 1st 15 times of amount of alcohol reflux with 90%, the 2nd 8 times of amounts) filter, merge extractive liquid,, decompression, concentrated gets concentrated solution, the capable again decocting of medicinal residues after the extraction boils twice, filter liquor is concentrated, merge above-mentioned two kinds of concentrated solutions, make fluid extract; Add strychnine 6.5g, Toadpoison Medicine 3.5g, cinnamic acid 10g and be ground into the Borneolum Syntheticum 10g stirring and evenly mixing of impalpable powder, promptly;
(4) preparation transdermal therapeutic agent: get Radix Clematidis 10g, fry Fructus Foeniculi 7g, Rhizoma Zingiberis 7g, Cortex Cinnamomi 7g, Rhizoma Drynariae 7g, Pyritum (calcined) 3g, 3 parts of Radix Et Rhizoma Nardostachyos, Flos Campsis 7g, Semen Momordicae 7g, Saussurea laniceps 7g, Fructus Evodiae 3g, Squama Manis 7g, Herba Pyrolae 7g, Folium Artemisiae Argyi 6g, Radix Aconiti 3g, Radix Aconiti Kusnezoffii 3g, Flos Caryophylli 3g be ground into coarse powder, ethanol with 75% (10 times of amounts) is percolation slowly, collect percolate, reclaim ethanol, concentrate; The capable again decocting of medicinal residues after the extraction boils twice, and filter liquor is concentrated, and merges above-mentioned two kinds of concentrated solutions, makes fluid extract; Add the Sanguis Draxonis 2g and the Venenum Bufonis 1g that are ground into impalpable powder and stir, promptly;
(5) preparation of pasting through the cave: get 3 parts of polymer matrixes, adds and above-mentionedly stir evenly through 1 part of cave curative effect agonist, coating, behind the placement 24h, cutting into diameter is the 3.5cm specification;
(6) preparation of skin-penetrating therapeutic subsides: get 3 parts of polymer matrixes, add above-mentioned transdermal therapeutic agent and stir evenly for 1 part, coating behind the placement 24h, cuts into 12cm * 16cm specification;
(7) will paste through the cave and skin-penetrating therapeutic pastes by fixed order (the nearly protective layer that reclines through the cave, skin-penetrating therapeutic recline nearly energy gathering ion layer) compoundly, paste then on the paster of step (1), and paste antiseized lining paper again and get final product.
The Polymer Porous Power-assembling Ion Jing Point Treatment Stick of embodiment 2 treatment mastopathy
Preparation process is with embodiment 1, and its difference is: inject negative polarity high-pressure electrostatic, surface electrical place value 1000-2500V with plasma method; Get Fructus Trichosanthis 10g, Semen Impatientis 10g, Radix Scutellariae 10g, Fructus Toosendan 10g, Herba Epimedii 15g, Rhizoma Corydalis 10g, Radix Curcumae 10g, Radix Rhapontici 10g, rhizoma sparganic 5g, Rhizoma Curcumae 5g, the Radix Linderae 5g during preparation transdermal therapeutic agent, use ethanol percolation; To paste through the cave and skin-penetrating therapeutic pastes by fixed order (the nearly protective layer that reclines through the cave, skin-penetrating therapeutic recline nearly energy gathering ion layer) compoundly, paste then on the energy gathering ion paster.
Preparation process is with embodiment 1, and its difference is: inject negative polarity high-pressure electrostatic, surface electrical place value 600-1500V with plasma method; Get Lignum Sappan 10g, Natrii Sulfas 10g, Lignum Pini Nodi 5g, Radix Aconiti 5g, Radix Aconiti Kusnezoffii 5g, Radix Ilicis Pubescentis 15g, Fructus Forsythiae 10g, Margarita powder 10g, Rhizoma Paridis 10g, Zaocys 10g, Squama Manis 5g, Spina Gleditsiae 5g, Radix Achyranthis Bidentatae 5g during the preparation transdermal therapeutic agent, use ethanol percolation; To paste through the cave and skin-penetrating therapeutic pastes by fixed order (the nearly protective layer that reclines through the cave, skin-penetrating therapeutic recline nearly energy gathering ion layer) compoundly, paste then on the energy gathering ion paster.
The Polymer Porous Power-assembling Ion Jing Point Treatment Stick of embodiment 4 treatment gynaecopathias
Preparation process is with embodiment 1, and its difference is: inject negative polarity high-pressure electrostatic, surface electrical place value 800-1500V with plasma method; Get Herba Verbenae 11g, Radix Scutellariae 8g, Fructus Gardeniae 11g, Pericarpium Zanthoxyli 8g, Rhizoma Belamcandae 8g, Fructus Piperis Longi 11g, Herba Houttuyniae 11g, Ramulus Cinnamomi 11g, Rhizoma Smilacis Glabrae 8g, Realgar 1g, Flos Rosae Rugosae 4g, Spina Gleditsiae 8g during the preparation transdermal therapeutic agent, use ethanol percolation; To paste through the cave and skin-penetrating therapeutic pastes by fixed order (the nearly protective layer that reclines through the cave, skin-penetrating therapeutic recline nearly energy gathering ion layer) compoundly, paste then on the energy gathering ion paster.
The Polymer Porous Power-assembling Ion Jing Point Treatment Stick of embodiment 5 treatment tumors
Preparation process is with embodiment 1, and its difference is: inject negative polarity high-pressure electrostatic, surface electrical place value 600-1500V with plasma method; Get Realgar 3g, Resina garciniae 4g, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 13g, Radix Kansui 3g, Radix Arnebiae (Radix Lithospermi) 20g, Herba Crotalariae sessiliflorae 4g, living Hemerocallis fulva L. 13g, buttercup 1g, water tinctorius seed 7g, Herba Verbenae 13g, Radix aconiti szechenyiani 3g, Radix Phytolaccae 3g, Herba Macleayae Cordatae 13g during the preparation transdermal therapeutic agent, use ethanol percolation; To paste through the cave and skin-penetrating therapeutic pastes by fixed order (the nearly protective layer that reclines through the cave, skin-penetrating therapeutic recline nearly energy gathering ion layer) compoundly, paste then on the energy gathering ion paster.
The clinical observation of test example 1 Polymer Porous Power-assembling Ion Jing Point Treatment Stick treatment osteoarthritis pain
Rheumatism involving the bone comprises diseases such as arthralgia that various joint diseases cause, enlargement, sclerotin injury, malfunction, is to be supported etc. due to the multiple reason by wind-cold damp pathogen invasion, gravity wound, the resistance of QI and blood numbness, visceral-qi weakness, muscles and bones mistake.The inventor carries out clinical observation to Polymer Porous Power-assembling Ion Jing Point Treatment Stick, and the joint disease patient who includes clinical summary in is totally 68 examples, existing method and result is reported as follows.
1 clinical data
1.1 case physical data
This group case is totally 68 examples, male's 35 examples wherein, women's 33 examples, minimum 21 years old of age of onset, maximum 66 years old.The course of disease is the shortest 2 months, and elder reaches 10 years.Hyperosteogeny 29 examples (cervical spondylosis 12 examples, lumbar spondylosis 8 examples, heel bone hyperosteogeny 5 examples, other hyperosteogeny 4 examples), femur head necrosis 6 examples, scapulohumeral periarthritis 11 examples, fracture 4 examples, arthritis 18 examples (rheumatic arthritis 7 examples, rheumatoid arthritis 6, gonarthritis 5 examples).
1.2 pain evaluation criterion
1.2.1 adopt Han Shi visual analogue scale (CVAS/ measures the assessment scoring): 0 is divided into painlessly, and 10 are divided into pain, divide 10 grades.
1.2.2 main suit's pain grade scale: according to WHO main suit's pain staging (VRS) standard.
0 degree: no pain;
The I degree: the slight pain of paroxysmal, can stand, can orthobiosis, diet and sleep;
The II degree: paroxysmal or rest pain are heavier, are impatient at, and daily routines, diet and sleep are under some influence, and need with weak opioid drug pain relieving;
The III degree: severe pain unbearably can not orthobiosis, diet and sleep, can accompany the autonomic nervous dysfunction.
2 Therapeutic Method
2.1 Therapeutic Method
Adopt group technology at random, 68 routine joint disease pain patients are divided into experimental group and matched group at random.Experimental group 35 examples wherein, matched group 33 examples are carried out statistical procedures to the non-treatment factor before two groups of patient treatments such as age, sex, pain degree, the sick kind, P>0.05, no significant difference has comparability.
Experimental group: stick energy gathering ion of the present invention through cave treatment subsides (osteoarthritis type), each 2~3 paste, and every subsides can stick 24 hours continuously, and 30 days is a course of treatment.
Osteoarthritis is selected the cave: master point is an Ashi point.Cervical vertebra adds big vertebra, chien cheng, wind pond; Lumbar vertebra adds in Yaoch'i (Extra) acupoint, Ba Liao, the committee; Knee joint adds Dubi, tsu san li, rich and prosperous.
Matched group: painful area external application " ZHUANGGU SHEXIANG ZHITONG GAO " (Henan Lingrui Pharmacy Stock Co., Ltd produces, lot number 040624), each 1~2 pastes, and continuous 30 days is a course of treatment.
2.2 clinical indexes and record
Subjective symptoms or sign: pain, numbness, aching and tired, unable, local tenderness, swelling etc.; Main suit's pain classified estimation (VRS); The CVRS value.
2.3 criterion of therapeutical effect:
Clinical cure: (1) pain clinical symptoms complete obiteration; (2) local tenderness disappears; (3) treatment back CVAS value drops to 0 fen person.
Produce effects: (1) pain clinical symptoms reaches 2/3 than preceding improvement of treatment, but still has mild pain; (2) local tenderness obviously alleviates; (3) CVAS difference (d) the decline 3-5 person of branch before and after self treats.
Effectively: (1) subjective symptoms takes a turn for the better to some extent, and pain reaches 1/3 than alleviating before treating, but still has pain; (2) local tenderness alleviates; (3) CVAS difference (d) the decline 1-2 person of branch before and after self treats.
Invalid: after treating 2 courses of treatment continuously, subjective symptoms does not have improvement, CVAS difference (d)<1 minute person before and after self treats.
3 therapeutic outcomes
Table 1 experimental group and matched group clinical efficacy are relatively
Routine number clinical cure produce effects enabledisable total effective rate divides into groups
(n) n(%) n(%) n(%) n(%) n(%)
Experimental group 35 12 (34.29) 13 (37.14) 8 (22.86) 2 (5.71) 33 (94.29)
*
Matched group 33 4 (12.12) 6 (18.18) 10 (30.31) 13 (39.39) 20 (60.61)
Annotate: x
2=11.20,
*P<0.01.
Table 2 Polymer Porous Power-assembling Ion Jing Point Treatment Stick is to the pain palliation efficacy of pain patients in various degree
Pain index VRS
x±s
N 0 degree I degree II degree III degree
Treat preceding 35 0 (0.00%) 3 (8.57%) 17 (48.576%) 15 (42.86%)
32.47±9.59
Treatment back 35 12 (34.29%) 12 (34.29%) 9 (25.71%) 2 (1.08%)
Annotate: before and after treating, self compares, t value=16.31,
*P<0.01
Table 3 Polymer Porous Power-assembling Ion Jing Point Treatment Stick treatment back clinical symptoms is improved situation
The numb myasthenia moving obstacle of pain and swelling
Treat preceding 35 22 15 12 19
Treatment back 11232
Doing well,improving rate 97.14% 95.45% 86.67% 75.00% 89.47%
4 conclusions
The pain that osteoarthrosis illness such as (1) clinical observation hyperosteogeny, femur head necrosis, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, fracture, gonarthrosis cause, swelling, dysfunction patient be totally 68 examples.Handle by statistics, and it is 94.29% that 35 routine osteopathia patients adopt energy gathering ion clinical total effective rate after treatment is pasted in the cave treatment, compares with matched group, and difference has significance, P<0.01.Experimental result shows: energy gathering ion pastes through the cave treatment has reducing swelling and alleviating pain, promoting the flow of QI in the collateral by warming the meridian, function of promoting blood circulation to disperse blood clots preferably to osteoarthrosis illness such as hyperosteogeny, femur head necrosis, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis, fracture, gonarthrosiss, its " ZHUANGGU SHEXIANG ZHITONG GAO " matched group of evident in efficacy being better than, difference has the significance meaning, P<0.01.
(2) energy gathering ion is treated the osteoarthritis pain patients of pasting in various degree through the cave all better pain relieving effect, the curative effect statistics shows: I degree pain patients 3 examples before the treatment, II degree pain patients 17 examples, III degree pain patients 15 examples, treatment back I degree pain patients 12 examples, II degree pain patients 9 examples, III degree pain patients is 2 examples only, 12 routine patient's pain complete obiterations are arranged after the treatment, pain index (VRS) treatment back is average to descend 32.47 ± 9.59, and relatively, difference has the significance meaning before and after the treatment, t value=16.31, P<0.01.
(3) energy gathering ion pastes local clinical symptoms such as pain that osteoarthrosis illness such as hyperosteogeny, femur head necrosis, rheumatic arthritis, rheumatoid arthritis, scapulohumeral periarthritis are caused, swelling, numbness, myasthenia, moving obstacle through cave treatment significant improvement effect, the improvement rate of treatment back pain is 97.14%, the improvement rate of swelling is 95.45%, numb improvement rate is 86.67%, amyasthenic improvement rate is 75.00%, the improvement rate of joint movement disorder is 89.47%
(4) untoward reaction: matched group has 2 routine patients with occurring local pruritus, erythema behind " ZHUANGGU SHEXIANG ZHITONG GAO " plaster, fades away in 5-6 days after the drug withdrawal, does not see other influence.
The clinical observation of test example 2 Polymer Porous Power-assembling Ion Jing Point Treatment Sticks treatment gynaecopathia
Include gynaecopathia patient totally 112 examples of cyclomastopathy, the pelvic inflammatory disease of clinical summary in, existing method and result are reported as follows.
1, general clinical data
1.1 physical data
The 115 routine patients that include clinical observation in are cyclomastopathy patient and the pelvic inflammatory disease patient that gynecological's outpatient service is made a definite diagnosis.Age: 12-26 year 22 examples, 27-40 year 48 examples, 41-50 year 31 examples, person's 11 examples more than 51 years old.Wherein: cyclomastopathy 57 examples, pelvic inflammatory disease 55 examples.The shortest person of the course of disease 2 months, elder 7 years.Pain degree: I degree pain 18 examples, II degree pain 64 examples, III degree pain 30 examples.
1.2 pain grading evaluation standard
0 degree: no pain.
I degree (mild pain): pain is slight, can stand no pain face, energy operate as normal, life, diet and sleep, no General Symptoms.Pain integration 5-10 branch.
II degree (moderate pain): pain is heavier, is impatient at, and face dolorosa is arranged, and the complexion white light is white, and extremity are not warm, but does not have uneasy in either sitting or lying; Daily life diet and sleep are subjected to influence to a certain degree, postpone with pain relieving measure pain, or need the medicine pain relieving.Pain integration 11-20 branch.
III degree (severe pain): pain unbearably, uneasy in either sitting or lying can not orthobiosis, diet and sleep, must lie up, and adopts the pain relieving measure not have obvious alleviation, can accompany the autonomic nervous dysfunction.Pain integration>20 minute.
2, Therapeutic Method and result
2.1 Therapeutic Method
With 112 routine cyclomastopathy, pelvic inflammatory disease patient is two groups of experimental group and matched groups at random.Wherein experimental group is 62 examples (cyclomastopathy 32 examples, pelvic inflammatory disease 30 examples), matched group is 50 examples (cyclomastopathy 25 examples, pelvic inflammatory disease 25 examples), two groups of patient aspects such as age, the course of disease, sick kind, pain degree and clinical manifestation before treatment compare and all do not have significant difference (P>0.05), have balanced comparability.
Experimental group: 1. cyclomastopathy: stick energy gathering ion of the present invention through cave treatment subsides-mammary gland type, stick the position: focus part, Danzhong, Rugen, Zhangmen, sp 6, each 2-3 subsides, every subsides can stick 24 hours continuously, and one month is a course of treatment.2. pelvic inflammatory disease: stick energy gathering ion through the scorching type of cave treatment subsides-woman, stick the position: focus part, sp 6, cv, the middle utmost point, Shenque, each 2-3 subsides, every subsides can stick 24 hours continuously, and one month is a course of treatment
Matched group: 1. cyclomastopathy: stick Weir mammary gland and paste (production of Shanghai Weir health care factory), stick in site of disease or acupuncture point, changed dressings once in per three days, 10 is a course of treatment.2. pelvic inflammatory disease: FUKE QIANJIN PIAN (production of Zhuzhou a thousand pieces of gold Pharmaceutical limited company), 6 slices/time, 3 times/day, oral.
2.2 efficacy assessment standard
2.2.1 the efficacy assessment standard of cyclomastopathy
Produce effects: mammary gland pain disappears, and the more former scope of tuberosity dwindles 2/3, the quality deliquescing.Extent of disease is corresponding dwindles for the scanning prompting of mammary gland near infrared ray.
Effectively: mammary gland pain alleviates, and the more former scope of tuberosity dwindles 1/3, the quality deliquescing.Extent of disease is corresponding dwindles for the scanning prompting of mammary gland near infrared ray.
Invalid: treatment back symptom and sign no change, mammary gland near infrared ray scanning prompting extent of disease does not have change.
2.2.2 the efficacy assessment standard of pelvic inflammatory disease
Produce effects: cardinal symptom, the most of disappearance of sign, hemogram is normal substantially, and the gynecologial examination pelvic lump dwindles, and the adnexa adhesion obviously alleviates.
Effectively: cardinal symptom, sign are partly alleviated, and hemogram partly improves, and gynecologial examination pelvic lump and adnexa adhesion alleviate to some extent.
Invalid: symptom, sign, hemogram and gynecologial examination all do not have improvement.
2.3 statistical method
Enumeration data adopts x
2Check is analyzed, and measurement data adopts t check or F check to analyze, and experimental data adopts SPSS For Windows10.0 version software to carry out statistical disposition,
3 clinical observation result
Two of clinical efficacy groups are compared behind table 4 curing mammary gland hyperplasia
Routine digital display effect enabledisable total effective rate divides into groups
Experimental group 32 19 (59.38%) 12 (37.50%) 1 (3.12%) 31 (96.88%) *
Matched group 25 8 (32.00%) 9 (36.00%) 8 (32.00%) 17 (68.00%)
Annotate: * represents relatively x of experimental group and matched group
2=8.801, P<0.01.
Two groups of table 5 pelvic inflammatory disease treatment back clinical efficacy relatively
Routine digital display effect enabledisable total effective rate divides into groups
Experimental group 30 14 (46.67%) 14 (46.67%) 2 (6.67%) 28 (93.33%)
Matched group 25 9 (36.00%) 7 (28.00%) 9 (36.00%) 16 (64.00%)
Annotate: * represents relatively x of experimental group and matched group
2=7.333, P<0.01.
Analgesic effect relatively behind the table 6 liang group gynecological pain disease patient treatment
Grouping
Pain degreeThe pain relieving entry-into-force time
0 degree (n) I degree (n) II degree (n) III degree (n) (min, x ± s)
Experimental group treatment preceding 0 10 34 18
Treatment back 17 30 12 3 8.50 ± 0.73
*
Treatment of control group preceding 08 30 12
Treatment back 3 12 19 16 24.36 ± 0.29
Annotate: * represents experimental group and matched group relatively, P<0.01.
4 clinical trial conclusions
Handle 4.1 learn by statistics, 32 routine cyclomastopathy patients adopt energy gathering ion clinical total effective rate 96.88% after the treatment of cave treatment subsides-mammary gland type, and the clinical total effective rate of matched group is 68.00%, compare for two groups, the therapeutic effect of " energy gathering ion is through cave treatment subsides-mammary gland type " significantly is better than " subsides of Weir mammary gland " matched group, difference has the significance meaning, P<0.01, clinical observation result shows: Polymer Porous Power-assembling Ion Jing Point Treatment Stick has dredge the meridian passage, the effect of analgesia eliminating stagnation preferably to the cyclomastopathy patient.
4.2 30 routine pelvic inflammatory disease patients adopt energy gathering ion clinical total effective rate 93.33% after the scorching type treatment of cave treatment subsides-woman, the clinical total effective rate 64.00% of matched group, compare for two groups, the therapeutic effect of " energy gathering ion is through the scorching type of cave treatment subsides-woman " significantly is better than " FUKE QIANJIN PIAN " matched group, the difference significance, P<0.01, clinical observation result shows: energy gathering ion pastes through the cave treatment has significant blood circulation promoting and blood stasis dispelling, analgesic antiphlogistic effect to the pelvic inflammatory disease patient.
4.3 the pain that cyclomastopathy, pelvic inflammatory disease patient is caused through clinical observation " energy gathering ion is through cave treatment subsides " has the obvious treatment effect, the pain relieving entry-into-force time is 8.50 ± 0.73, the matched group pain relieving entry-into-force time is 24.36 ± 0.29, " FUKANG Polymer Porous Power-assembling Ion Jing Point Treatment Stick " obviously is better than matched group to the curative effect of gynecological's pain disease, learn by statistics and handle, significant difference is arranged, P<0.01.
The clinical observation of test example 3 Polymer Porous Power-assembling Ion Jing Point Treatment Sticks treatment peripheral vascular disease
Include varicosis patient's 31 examples of clinical observation in, vasculitis patient's 33 examples.Now method and result are reported as follows.
1, observation index
(1) conscious and objective sign shape and sign: suffer from acropathy before and after the treatment and become partial pain, swelling degree and local color of the leather change situation.
(2) blood examination: whole blood viscosity, plasma viscosity, packed cell volume, erythrocyte electrophoretic time.
2, the diagnostic criteria of case and choice criteria: with reference to " new Chinese medicine clinical research guideline ".
3, therapeutic evaluation standard
(1), the therapeutic evaluation standard of varicose veins of the lower extremity
Produce effects: suffer from that limb stands for a long time that the back is heavy, swelling, pain disappears, pigmentation changes, but still has slight superficial vein expansion, incliner.
Effectively: suffer from that limb stands for a long time that the back is heavy, swelling, pain takes a turn for the better, but the person of being clearly better is not seen in superficial vein bending, expansion.
Invalid: sings and symptoms does not have improvement.
(2), vasculitic therapeutic evaluation standard
Produce effects: 1. clinical symptoms obviously changes; 2. limbs wound healing or approaching healing; 3. limbs peripheral blood circulatory disturbance and rheography all have improvement; 4. walking speed 100~120 step/minute, can continue about walking 500m.
Effectively: 1. clinical symptom relief; 2. the limbs wound surface is near healing or dwindling; 3. limbs peripheral blood circulatory disturbance and rheography slightly improve; 4. walking speed 100~120 step/minute, can continue about walking 300m.
Invalid: clinical symptoms and sign do not have improvement or the state of an illness continues development person.
4, Therapeutic Method
The prescription that arteries and veins health energy gathering ion of the present invention pastes through the cave treatment is made up of Lignum Sappan, Natrii Sulfas, Lignum Pini Nodi, Radix Aconiti, Radix Aconiti Kusnezoffii, Radix Ilicis Pubescentis, Fructus Forsythiae, Margarita powder, Rhizoma Paridis, Zaocys, Squama Manis, Spina Gleditsiae, Radix Achyranthis Bidentatae.Stick the position: acupuncture points such as focus part, Ashi point, tsu san li, sp 6, each 2-3 pastes, and every subsides can stick 24 hours continuously, and one month is a course of treatment.
5, clinical test results
Table 7 arteries and veins health energy gathering ion pastes through the cave treatment clinical efficacy of peripheral vascular disease is added up
Routine digital display effect enabledisable total effective rate divides into groups
Varicosis 31 16 (51.61%) 13 (41.94%) 2 (6.45%) 29 (93.55%)
Vasculitis 33 11 (33.33%) 19 (57.56%) 3 (9.09%) 30 (90.91%)
Add up to 64 27 (42.19%) 32 (50.00%) 5 (7.81%) 59 (92.19%)
The improvement situation of table 8 arteries and veins health energy gathering ion clinical symptoms after treatment is pasted in the cave treatment
Routine number incidence rate takes place and improves routine number improvement rate in symptom
Pain 44 93.61% 42 95.45%
Swelling 33 70.21% 30 90.91%
Numb 21 44.68% 18 85.71%
Vein curls 30 63.83% 27 90.00%
Pigmentation 27 57.45% 23 85.19%
Tired unable 30 63.83% 23 76.67%
Table 9 arteries and veins health energy gathering ion blood index before and after treatment is pasted in the cave treatment changes relatively
Treatment back P value before the treatment of project unit
Low mPa/s 11.91 ± 2.62 7.56 ± 1.55<0.01 of cutting of whole blood contrast viscosity
The whole blood contrast viscosity height is cut mPa/s 5.68 ± 1.23 5.11 ± 1.16<0.05
Plasma viscosity mPa/s 2.54 ± 0.39 1.68 ± 0.42<0.01
Packed cell volume % 41.08 ± 2.36 41.06 ± 2.05>0.05
Fibrinogen g/L 3.71 ± 1.38 3.37 ± 1.32<0.05
Platelet aggregation rate % 58.25 ± 3.18 55.56 ± 3.30<0.05
6 clinical trial conclusions
(1) clinical observation meets varicosis patient's 31 examples that case is included standard in, vasculitis patient's 33 examples, 64 routine peripheral vascular disease patients are after " arteries and veins health energy gathering ion is through cave treatment subsides " treatment, its clinical total effective rate is 92.19%, wherein cirsoid clinical total effective rate is 93.55%, obvious effective rate is 51.61%, and vasculitis patient's clinical total effective rate is 90.91%, and obvious effective rate is 33.33%.Clinical observation result shows: arteries and veins health energy gathering ion pastes through the cave treatment has blood circulation promoting and blood stasis dispelling, promoting flow of qi by warming channel, reducing swelling and alleviating pain effect preferably to varicosis and vasculitis.
(2) arteries and veins health energy gathering ion through cave treatment paste that pain, swelling, numbness, vein that varicosis and vasculitis patient are caused curl, pigmentation, tired clinical symptoms such as unable all have significant improvement, clinical symptoms improvement rate to pain is 95.45%, the improvement rate of swelling is 90.91%, numb improvement rate is 85.71%, the improvement rate that vein curls is 90.00%, and tired unable improvement rate is 76.67%.
(3) varicosis patient and vasculitis patient passages through which vital energy circulates health energy gathering ion are after treatment is pasted in the cave treatment, whole blood contrast viscosity in its hemorheology, plasma viscosity, Fibrinogen and platelet aggregation rate index obviously reduce before the treatment, relatively, difference has significance (P<0.05 or P<0.01) before and after the treatment.No significant change (P>0.05) before and after the packed cell volume treatment.Clinical observation result shows: Polymer Porous Power-assembling Ion Jing Point Treatment Stick has the hemocyte of preventing and adheres to and accumulative anti thrombotic action.
(4) safety evaluatio: in the observation process, unusual subjective symptoms and untoward reaction do not occur.
The clinical observation of test example 4 Polymer Porous Power-assembling Ion Jing Point Treatment Sticks treatment cancer
Pain is the most common, one of the most insufferable symptom of patient with advanced cancer, has a strong impact on the middle and terminal cancer patients ' life quality.Subside a swelling, the Polymer Porous Power-assembling Ion Jing Point Treatment Stick of promoting the flow of QI in the collateral by warming the meridian effect by analgesia with having for I chief minister, adopt the group technology of completely randomization, the cancer pain patient that 31 examples is met the standard of including in has carried out clinical observation, simultaneously carry out synchronous clinical comparison, now clinical summary is reported as follows with matched group.
1 clinical data
1.1 general clinical data
This group case 61 examples (experimental group 31 examples, matched group 30 examples) are the cancer pain patient who makes a definite diagnosis through I level (pathology or cytology) and II level (uniting diagnosis for two in CT, MRI, X line, the B ultrasonic) clinical diagnosis.Wherein male 29 examples, women 32 examples; Age 23-71 year, 54.32 years old mean age.Pulmonary carcinoma 10 examples, intestinal cancer 10 examples, hepatocarcinoma 11 examples, the esophageal carcinoma 8 examples, gastric cancer 9 examples, breast carcinoma 6 examples, carcinoma of prostate 3 examples, bladder cancer 2 examples, carcinoma of gallbladder 2 examples.The cancer pain degree through VAS assessment all in 2~10 scopes, II level cancer pain patient 6 examples wherein, III level cancer pain patient 22 examples, IV level cancer pain patient 25 examples, V level cancer pain patient 8 examples.
1.2 the pain classification and quality of life standards of grading
1.2.1 pain classification (NRS)
Carry out classification (0~10 minute) according to " cancer numeral pain staging " that World Health Organization (WHO) formulates: the I level: 0 be divided into painless; The II level: 1~3 is divided into mild pain; The III level: 4~6 are divided into moderate pain; The IV level: 7~9 are divided into severe pain; The V level: 10 are divided into insufferable having an intense pain.
1.2.2 the quality of life scoring is with reference to " Capital University of Medical Sciences's journal " 2003 the 24th the 3rd phases of volume.
2 Therapeutic Method
2.1 group technology
Adopt the group technology of 1: 1 completely randomization, divide experimental group n=31 at random, matched group n=30, non-treatment factor before two groups of patient treatments such as sex, age, cancer kind and pain degree etc. are learned processing by statistics, P>0.05, no significant difference has balanced comparability.
2.2 Therapeutic Method
Experimental group: stick Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention, prescription is made up of Realgar, Resina garciniae, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Kansui, Radix Arnebiae (Radix Lithospermi), Herba Crotalariae sessiliflorae, living Hemerocallis fulva L., buttercup, water tinctorius seed, Herba Verbenae, Radix aconiti szechenyiani, Radix Phytolaccae, Herba Macleayae Cordatae.
Applying method: stick in the local and relevant acupuncture point of focus.Master point: Pishu, bl, bl, tsu san li, Shenque.The respiratory system cancer adds Danzhong, Rugen; The liver and gall cancer adds Zhangmen, Qimen; Cancer in digestive system adds Danzhong, mastoid process, Shangwan, the middle part of gastric cavity; Intestinal cancer and urinary system cancer add the middle utmost point, cv, Tianshu.Each optional 2-3 acupuncture point, every subsides can stick 24 hours continuously.Three weeks were a course of treatment.
Matched group: awei huapi plaster, awei huapi gao (liking that by Jinan people pharmaceutical Co. Ltd provides lot number 2003120210) sticks in SHENQUE acupoint, Danzhong and affected part, and three weeks were a course of treatment.
2.3 clinical indexes: pain intensity, pain classification, quality of life scoring.
2.4 statistical method: adopt x
2Check and t check.
2.5 efficacy assessment standard: according to the method evaluation analgesia effect of " practical Internal Medicine-Oncology ".
Alleviate fully (CR): painless.
Obviously alleviate (PR): pain obviously alleviates before the treatment, and it is interference-free substantially to sleep, can orthobiosis.
Part is alleviated (MR): pain alleviates before the treatment, but still feels pain, sleep is disturbed.
Invalid (NR): with before the treatment relatively pain do not have and alleviate.
3 clinical test results analyses
Clinical efficacy comparison behind the table 10 liang group cancer pain patient treatment (n, %)
Alleviate fully obviously to alleviate and partly alleviate invalid total effective rate
Routine number divides into groups
(CR) (MR) (PR) (NR) (CR+MR+PR)
Matched group 30 5 (16.67%) 6 (20.00%) 9 (30.00%) 10 (33.33%) 20 (66.67%)
Experimental group 31 13 (41.94%) 11 (35.48%) 6 (19.35%) 1 (3.23%) 30 (96.77%) *
Annotate: * represents experimental group and matched group relatively, P<0.01.
Table 11 Polymer Porous Power-assembling Ion Jing Point Treatment Stick is to the analgesic effect comparison of cancer pain in various degree
Obvious effective rate (%) total effective rate (%)
Pain degree example number (n) CR (n) MR (n) PR (n) NR (n)
(CR+MR) (CR+MR+PR)
Mild pain 330003 (100%) 3 (100%)
Moderate pain 11 36209 (81.82%) 11 (100%)
Severe pain 12 63309 (75.00%) 12 (100%)
Have an intense pain 512113 (60.00%) 4 (80.00%)
Add up to 31 13 11 61 24 (77.42%) 30 (96.77%)
Table 12 Polymer Porous Power-assembling Ion Jing Point Treatment Stick is to comparing before and after the cancer pain patient treatment of quality of life
Treatment back P value before the project treatment
Appetite 2.84 ± 0.45 4.43 ± 0.22<0.01
Sleep 2.77 ± 0.17 4.55 ± 0.39<0.01
Spirit 1.89 ± 0.31 4.23 ± 0.24<0.01
Daily routines 3.11 ± 0.23 4.48 ± 0.29<0.05
4 clinical trial conclusions
4.1 analgesic effect: clinical total effective rate 96.77% after the Polymer Porous Power-assembling Ion Jing Point Treatment Stick treatment, the clinical total effective rate 66.67% of matched group, compare for two groups, the relieving pain of Polymer Porous Power-assembling Ion Jing Point Treatment Stick is better than " awei huapi plaster, awei huapi gao " matched group, the difference significance, P<0.01.Polymer Porous Power-assembling Ion Jing Point Treatment Stick sees Table 2 to cancer pain patient analgesic effect in various degree, mild pain, moderate pain, severe pain and the obvious effective rate that has an intense pain are respectively 100%, 81.82%, 75.00%, 60.00%, the prompting Polymer Porous Power-assembling Ion Jing Point Treatment Stick has analgesic activity preferably to cancer pain patient, its clinical pain palliation efficacy obviously is better than matched group, P<0.01.
4.2 the improvement situation of quality of life: cancer pain patient is after the Polymer Porous Power-assembling Ion Jing Point Treatment Stick treatment; its quality of life obviously improves before the treatment; wherein on average improved 1.59 fens before and after the appetite treatment; sleep improved 1.78 fens; the mental status improved 2.34 fens; daily routines improved 1.37 fens, and the prompting Polymer Porous Power-assembling Ion Jing Point Treatment Stick has and improves cancer pain patient quality of life, regulates human-body viscera function, corrects the effect of pathology disturbance state.
Test example 5 Polymer Porous Power-assembling Ion Jing Point Treatment Stick transdermal test in vitro absorption experiment
1. experiment material
Polymer Porous Power-assembling Ion Jing Point Treatment Stick of the present invention: rich living medical Technology Dev Company Ltd. provides by Zhengzhou, adopt polytetrafluoroethylporous porous membrane (aperture 1-5 μ m, cell size 50%), film thickness 60 μ m, by ME-TL type high-pressure electrostatic corona (the ME TECH CO. of system, LTD USA) implements room temperature constant voltage corona charging to polytetrafluoroethylporous porous membrane, make its surface electrostatic lotus be-500~-1000V (the charging afterwards surface charge of sample is measured by penalty method).Prescription is made up of strychnine, Toadpoison Medicine, Borneolum Syntheticum, Folium Fructus Broussonetiae, Rhizoma Pinelliae, Rhizoma Kaempferiae, Fructus Capsici.
Paste at the acupuncture point: rich living medical Technology Dev Company Ltd. provides by Zhengzhou, and prescription is made up of strychnine, Toadpoison Medicine, Borneolum Syntheticum, Folium Fructus Broussonetiae, Rhizoma Pinelliae, Rhizoma Kaempferiae, Fructus Capsici.
Strychnine reference substance (Nat'l Pharmaceutical ﹠ Biological Products Control Institute provides), reagent is analytical pure.
Instrument: TP23 type transdermal diffusion test instrument (China Medicine University), Beckman spectrophotometer (U.S.), Beckman refrigerated centrifuger (U.S.), constant temperature magnetic stirrer (Shanghai Si Le instrument plant), Hewlett-Packard's gas chromatograph (U.S.).
Animal: Kunming kind white mice, ♂, 18~22g is available from Henan Province's Experimental Animal Center.
2 experimental techniques and result
2.1 the preparation of strychnine standard curve
2.1.1 chromatographic condition chromatographic column: chromatographic column is HypersilODS (2.5mm * 200mm, 5 μ m), and mobile phase is methanol: sour water=60: 40 (transferring PH=3 with glacial acetic acid), flow velocity 1.0mL/min, detect wavelength 272nm, column temperature (25 ± 0.1) ℃, external standard method is quantitative.
2.1.2 the strychnine standard substance are got in the preparation of standard curve, with the chloroform dissolving, make the standard reference material solution of 0.5mg/ml.The accurate strychnine standard reference material solution 2ml that draws, 3ml, 4ml, 5ml, 6ml add mobile phase to scale in the 10ml measuring bottle, shake up, and be standby.Under the chromatographic condition of determining to get well, get 10 μ l sample introductions, with peak area the amount of strychnine is done regression analysis, must regression equation be: A=348.304+12.812t, r=0.865 has good linear relationship.
2.2 Transdermal absorption experiment
2.2.1 preparation rat skin in vitro: get male Kunming kind white mice, after the depilatory cream depilation, warm water cleaning skin, natural feeding one day.Disconnected neck is put to death before experiment next day, peels off skin of abdomen immediately, removes clean subcutaneous tissue, cleans with normal saline, soaks, and puts refrigerator and cooled and hides standby.
2.2.2 infiltration disperser TP23 type transdermal diffusion test instrument adopts improved Franz diffusion cell, comprise the constant temperature magnetic stirrer, diffuser casing, receiving chamber, middle part and top-side in receiving chamber are equipped with a probe tube and exhaustor respectively, probe tube is used for sampling and replenishes acceptable solution, and exhaustor is used to get rid of bubble.Diffuser casing and receiving chamber's interfaces diameter are 2.0cm, and the transdermal area is 2.25cm
2
2.2.3 Transdermal absorption test method
[1]
Corium Mus is cut into 3 of suitable size, be separately fixed between the confession coyote hole and receiving chamber of 3 cover Transdermal absorption experimental provisions, stratum corneum side is to diffuser casing, injecting normal saline in receiving chamber makes the probe tube liquid level exceed skin, open the constant temperature magnetic stirrer, temperature (37 ± 2) ℃, rotating speed 100r/min constant speed stirs, will " Polymer Porous Power-assembling Ion Jing Point Treatment Stick " (experimental group) and acupuncture point subsides (matched group) evenly be pasted on the diffuser casing Corium Mus and become 2cm
2Circular, closely contact with keratodermatitis one side, middle no bubble, do not interspace, fix diffuser casing, the record load time, draw the 5ml acceptable solution respectively at 2,4,6,8,12, behind the 24h, add the fresh normal saline of 5ml simultaneously, allowance for bark down bubble side by side and carry out Transdermal absorption experiment, the trap value of under ultraviolet spectrophotometer, measuring.With blank skin is the retinue contrast, to reduce experimental error.The accumulation infiltration capacity is calculated as follows.
Accumulation infiltration capacity Q=Qn/A Qn=Cn * V+ ∑ Cn-1 * Vsn-1
Annotate: gauged accumulation infiltration capacity when Qn is different sample point; Acceptable solution measured concentration when Cn is different sample point; V is long-pending for accepting cell body: Vs is that sample volume: A is for supplying pond, medicine pond open area.
2.3 experimental result
Table 13 Polymer Porous Power-assembling Ion Jing Point Treatment Stick is to the accumulation infiltration capacity of mice isolated skin (x ± s)
Accumulation infiltration capacity (μ g/ml)
Grouping
1h 2h 4h 6h 8h 12h 24h
Experimental group 332.8 ± 2.8 4474 ± 3.3 597.2 ± 3.1 768.6 ± 3.7 1045.8 ± 2.2 1168.5 ± 2.6 1259.7 ± 2.1
Matched group 253.3 ± 2.3 303.6 ± 3.1 379.5 ± 2.4 482.8 ± 3.8 603.1 ± 1.9 698.4 ± 2.2 712.3 ± 2.0
Table 14 Polymer Porous Power-assembling Ion Jing Point Treatment Stick is to mice transdermal test in vitro absorption parameter
Grouping Q~t regression equation r F
Experimental group 476.882+40.032t 0.873 16.040
Matched group 325.742+20.224t 0.859 14.134
The accumulation infiltration capacity curve of matched group and experimental group as shown in Figure 3.
Experimental result shows: " Polymer Porous Power-assembling Ion Jing Point Treatment Stick " Transdermal absorption is good, its accumulation infiltration capacity (Q) under day part is all pasted apparently higher than the acupuncture point, its strychnine transdermal accumulation infiltration capacity is single 1.73 times of pasting matched group with the acupuncture point in the 8h period, experimental group and matched group are relatively, significant difference is arranged, P<0.01.To accumulate infiltration capacity Q time t will be carried out regression analysis, the Q of experimental group and matched group and t are all linear, " Polymer Porous Power-assembling Ion Jing Point Treatment Stick " is along with the prolongation of time, the accumulation infiltration capacity increases gradually and tends towards stability, infer thus, " Polymer Porous Power-assembling Ion Jing Point Treatment Stick " can keep more stable blood drug level, the drug release time of " Polymer Porous Power-assembling Ion Jing Point Treatment Stick " can be kept about 24h, medicine can accumulate in skin in the Transdermal absorption process and form the storage storehouse, and the formation in storage storehouse is because the free drug that is dissolved in the horny layer causes with the medicine that is incorporated in the horny layer.Because the effect of energy gathering ion in " Polymer Porous Power-assembling Ion Jing Point Treatment Stick ", can quicken to put aside the drug diffusion in horny layer, therefore, its accumulation infiltration capacity is higher than list far away and pastes with the acupuncture point, prompting thus, " Polymer Porous Power-assembling Ion Jing Point Treatment Stick " have tangible medicine ion and urge the effect of oozing.
Claims (8)
1, a kind of Polymer Porous Power-assembling Ion Jing Point Treatment Stick; comprise the medical pressure-sensing glue-line in the outside, intermediary protective layer through cave treatment paste layer and inboard; be provided with directed even current potential body layer and energy gathering ion layer at the medical pressure-sensing glue-line and between cave treatment paste layer; wherein directed even current potential body layer is adjacent with the medical pressure-sensing glue-line, pastes by pasting through the cave subsides with according to the skin-penetrating therapeutic that the treatment disease specific is selected through the cave treatment and forms.
2, Polymer Porous Power-assembling Ion Jing Point Treatment Stick according to claim 1, it is characterized in that: in paste in the cave, comprise following components by weight ratio through cave curative effect agonist, strychnine 2.5-8 part, Toadpoison Medicine 0.5-4 part, Borneolum Syntheticum 5-10 part, cinnamic acid 5-15 part, Folium Fructus Broussonetiae 15-30 part, Rhizoma Pinelliae 5-20 part, Rhizoma Kaempferiae 5-20 part, Fructus Capsici 5-20 part are all in weight portion.
3, Polymer Porous Power-assembling Ion Jing Point Treatment Stick according to claim 1, it is characterized in that: the prescription that the skin-penetrating therapeutic of treatment osteoarthritis pastes is, Radix Clematidis 5-15 part, fry Fructus Foeniculi 1-10 part, Rhizoma Zingiberis 1-10 part, Cortex Cinnamomi 1-10 part, Rhizoma Drynariae 1-15 part, Pyritum (calcined) 1-3 part, Radix Et Rhizoma Nardostachyos 1-5 part, Sanguis Draxonis 1-2 part, Venenum Bufonis 0.5-1 part, Flos Campsis 1-10 part, Semen Momordicae 1-10 part, Saussurea laniceps 1-10 part, Fructus Evodiae 0.5-3 part, Squama Manis 1-10 part, Herba Pyrolae 5-15 part, Folium Artemisiae Argyi 5-10 part, Radix Aconiti 1-3 part, Radix Aconiti Kusnezoffii 1-3 part, Flos Caryophylli 0.5-3 part is all in weight portion.
4, Polymer Porous Power-assembling Ion Jing Point Treatment Stick according to claim 1, it is characterized in that: the prescription that the skin-penetrating therapeutic of treatment hyperplasia of mammary glands pastes is, Fructus Trichosanthis 5-15 part, Semen Impatientis 5-15 part, Radix Scutellariae 5-10 part, Fructus Toosendan 10-15 part, Herba Epimedii 5-15 part, Rhizoma Corydalis 5-10 part, Radix Curcumae 5-10 part, Radix Rhapontici 5-10 part, rhizoma sparganic 5-10 part, Rhizoma Curcumae 5-10 part, Radix Linderae 5-10 part are all in weight portion.
5, Polymer Porous Power-assembling Ion Jing Point Treatment Stick according to claim 1, it is characterized in that: the prescription that the skin-penetrating therapeutic of treatment gynaecological inflammation disease pastes is, Herba Verbenae 5-15 part, Radix Scutellariae 5-15 part, Fructus Gardeniae 5-15 part, Pericarpium Zanthoxyli 3-10 part, Rhizoma Belamcandae 5-15 part, Fructus Piperis Longi 5-15 part, Herba Houttuyniae 5-15 part, Ramulus Cinnamomi 10-15 part, Rhizoma Smilacis Glabrae 5-15 part, Realgar 0.5-1 part, Flos Rosae Rugosae 1-5 part, Spina Gleditsiae 1-10 part are all in weight portion.
6, Polymer Porous Power-assembling Ion Jing Point Treatment Stick according to claim 1, it is characterized in that: the prescription that the skin-penetrating therapeutic of treatment vasculitis, varicose vein disease pastes is, Lignum Sappan 5-10 part, Natrii Sulfas 5-10 part, Lignum Pini Nodi 1-5 part, Radix Aconiti 1-5 part, Radix Aconiti Kusnezoffii 1-5 part, Radix Ilicis Pubescentis 10-15 part, Fructus Forsythiae 10-15 part, Margarita powder 5-10 part, Rhizoma Paridis 5-10 part, Zaocys 5-10 part, Squama Manis 1-5 part, Spina Gleditsiae 2-5 part, Radix Achyranthis Bidentatae 2-5 part are all in weight portion.
7, Polymer Porous Power-assembling Ion Jing Point Treatment Stick according to claim 1, it is characterized in that: the prescription that the skin-penetrating therapeutic of treatment tumor pastes is, Realgar 1-3 part, Resina garciniae 1-4 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 5-15 part, Radix Kansui 0.5-3 part, Radix Arnebiae (Radix Lithospermi) 5-20 part, Herba Crotalariae sessiliflorae 1-5 part, living Hemerocallis fulva L. 5-15 part, buttercup 0.5-1 part, water tinctorius seed 5-10 part, Herba Verbenae 5-15 part, Radix aconiti szechenyiani 1-3 part, Radix Phytolaccae 1-3 part, Herba Macleayae Cordatae 5-15 part are all in weight portion.
8, a kind of preparation is through the method for cave curative effect agonist, this method comprises: get Folium Fructus Broussonetiae, Rhizoma Pinelliae, Rhizoma Kaempferiae, Paprika and be broken into coarse powder, twice filtration of alcohol reflux with 90%, merge extractive liquid,, decompression, concentrated gets concentrated solution, the capable again decocting of medicinal residues after the extraction boils twice, filter liquor is concentrated, merge above-mentioned two kinds of concentrated solutions, make fluid extract; Add strychnine, Toadpoison Medicine, cinnamic acid and be ground into the Borneolum Syntheticum stirring and evenly mixing of impalpable powder, promptly.
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CNB2004101026700A CN100525751C (en) | 2004-12-29 | 2004-12-29 | Meridian point therapeutic plaster of high polymer multi hole energy gathering ion and its preparation method and application |
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CNB2004101026700A CN100525751C (en) | 2004-12-29 | 2004-12-29 | Meridian point therapeutic plaster of high polymer multi hole energy gathering ion and its preparation method and application |
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CN100525751C CN100525751C (en) | 2009-08-12 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101559255A (en) * | 2009-05-14 | 2009-10-21 | 北京中英联动技术服务有限公司 | Compound electret membrane, preparation method thereof and use thereof |
CN101856539A (en) * | 2010-06-22 | 2010-10-13 | 上海交通大学 | Electrostatic acupoint plaster |
CN102370855A (en) * | 2010-08-04 | 2012-03-14 | 张玉华 | Chinese medicinal herbal typhonium giganteum external medicament |
CN102921111A (en) * | 2012-12-02 | 2013-02-13 | 徐国元 | Far infrared static ear pressing paste |
CN109011133A (en) * | 2018-09-19 | 2018-12-18 | 广东泰宝医疗科技股份有限公司 | A kind of physical therapy plaster and preparation method thereof for preventing and treating the proliferation of mammary gland |
CN109200242A (en) * | 2018-09-19 | 2019-01-15 | 广东泰宝医疗科技股份有限公司 | It is a kind of cream health patch and preparation method thereof |
-
2004
- 2004-12-29 CN CNB2004101026700A patent/CN100525751C/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101559255A (en) * | 2009-05-14 | 2009-10-21 | 北京中英联动技术服务有限公司 | Compound electret membrane, preparation method thereof and use thereof |
CN101856539A (en) * | 2010-06-22 | 2010-10-13 | 上海交通大学 | Electrostatic acupoint plaster |
CN102370855A (en) * | 2010-08-04 | 2012-03-14 | 张玉华 | Chinese medicinal herbal typhonium giganteum external medicament |
CN102921111A (en) * | 2012-12-02 | 2013-02-13 | 徐国元 | Far infrared static ear pressing paste |
CN109011133A (en) * | 2018-09-19 | 2018-12-18 | 广东泰宝医疗科技股份有限公司 | A kind of physical therapy plaster and preparation method thereof for preventing and treating the proliferation of mammary gland |
CN109200242A (en) * | 2018-09-19 | 2019-01-15 | 广东泰宝医疗科技股份有限公司 | It is a kind of cream health patch and preparation method thereof |
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Publication number | Publication date |
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CN100525751C (en) | 2009-08-12 |
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