CN1593551A - Blood fat lowering capsule or tablet and its preparation - Google Patents
Blood fat lowering capsule or tablet and its preparation Download PDFInfo
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- CN1593551A CN1593551A CNA2004100256550A CN200410025655A CN1593551A CN 1593551 A CN1593551 A CN 1593551A CN A2004100256550 A CNA2004100256550 A CN A2004100256550A CN 200410025655 A CN200410025655 A CN 200410025655A CN 1593551 A CN1593551 A CN 1593551A
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Abstract
The invention discloses a blood fat lowering capsule or tablet and its preparation, wherein the preparation is prepared from root of red rooted saliva 0.5-1.5 parts, haw 0.5-1.5 parts, cassia seed 0.5-1.5 parts through weighing, washing, water boiling, filtering, merging filtrate, concentrating into thick extract, charging red rice, stirring homogeneously, transferring into baking oven for baking at 50-70 deg. C, taking-up, disintegrating into 60-80 meshes, loading into capsule or charging starch grout, pressing into tablets.
Description
Technical field
The present invention relates to a kind of blood fat reducing capsule or tablet and preparation method thereof.
Background technology
Hyperlipidemia to the infringement of health be concealment, gradually, carrying out property and general.Early stage hyperlipemia majority does not have clinical symptoms, and this also is the major reason that a lot of people think little of early diagnosis and early treatment.The direct infringement of hyperlipidemia is to quicken systemic atherosclerosis, because the vitals of whole body all will rely on tremulous pulse blood supply, oxygen supply, in case tremulous pulse is stopped up by atheromatous plaque, will cause serious consequence.The renal failure that arteriosclerosis causes etc., all closely related with hyperlipemia.
A large amount of research datas show that hyperlipemia is apoplexy, coronary heart disease, myocardial infarction, cardiac sudden death is independent and important risk.In addition, hyperlipemia also is an important risk factor that promotes hypertension, impaired glucose tolerance, diabetes.Hyperlipemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.Therefore prevention and treatment hyperlipidemia just seem particularly important.
Monas cuspurpureus Went: be exactly the good merchantable brand of medicine food dual-purpose since ancient times, Chinese scholars found that Monas cuspurpureus Went can very strong cholesterol-lowering activity material and the material for lowering blood pressure of generation effect in recent years.The Monas cuspurpureus Went that carries out according to Zhejiang Center For Disease Control and Prevention shows the influence experiment of experimental hyperlipidemia rat body weight and blood lipid level, when with 1.0g/kg dosage feed 4 weeks of hyperlipidemia rats, can significantly reduce serum cholesterol (TC) content and serum triglycerides (TG) content, prove that Monas cuspurpureus Went has the blood lipid regulation effect.
Radix Salviae Miltiorrhizae: Radix Salviae Miltiorrhizae is a Labiatae herbaceous plant for many years, as the Chinese medicine that activates the stasis of blood simply, have anticoagulation, fibrinolysis enhancing, antithrombotic effect, and can blood fat reducing, to the antilipemic oxidation, suppress the expression of blood adhesion molecule, Radix Salviae Miltiorrhizae and preparation thereof are widely used in the treatment of cardiovascular disease in recent years.The experiment of Meng Zhenhang etc. shows, Radix Salviae Miltiorrhizae can make cholesterol (TC) glyceride (TG) and low density lipoprotein, LDL (LDL) reduce to a certain extent, discovery Radix Salviae Miltiorrhizaes such as Wang Peng can suppress high lipid diet rabbit blood fat and rise, delay the atherosclerotic formation that hyperlipemia and endothelial injury factor cause jointly, it is narrow to alleviate the arterial lumen that atheromatous plaque causes.
Fructus Crataegi: middle Fructus Crataegi has the effect of blood circulation promoting and blood stasis dispelling, it is again the key medicine of greasy meat stagnation of disappearing, modern pharmacological research proof Fructus Crataegi can make the lecithin in the blood raise, cholesterol and the lipid deposition on organ is reduced, and its extract Semen Crataegi total triterpene acid can reduce the serum TC and the TG of mouse model.
Semen Cassiae: modern medicine study shows that Semen Cassiae has the effect that reduces TC in the serum, and non-evident effect.
Summary of the invention
The purpose of this invention is to provide a kind of blood fat reducing capsule or tablet and preparation method thereof.
The composition by weight of blood fat reducing capsule or tablet is: 1 part in Monas cuspurpureus Went, 0.5～1.5 part of Radix Salviae Miltiorrhizae, 0.5～1.5 part of Fructus Crataegi, 0.5～1.5 part of Semen Cassiae.
The preparation method of blood fat reducing capsule or tablet: component is by weight: 0.5～1.5 part of Radix Salviae Miltiorrhizae, 0.5～1.5 part of Fructus Crataegi, 0.5～1.5 part of ratio of Semen Cassiae are weighed, clean, the decocting that adds 5～10 times of weight of above-mentioned raw material boiled 1～2 hour, filter, get filtrate, so repeat 2～3 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 50～70 ℃ are dried by the fire to moisture and are lower than 3～5%, take out, be crushed to 60～80 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
The present invention is safe and effective, and taking dose is little.
1. show through Zhejiang Academy of Medical Sciences health food institute (State Food and Drug Administration's assigned food toxicology detects unit) toxicologic study:
1) acute toxicity: the blood fat reducing capsule is to rat, its mouse oral LD
50Male and female belong to non-toxic type all greater than the 20g/kg body weight.
2) micronucleus test: the blood fat reducing capsule is negative to PCEMNR micronucleus test testing result.
3) the abnormal property of mouse sperm test: the blood fat reducing capsule is negative to mouse sperm abnormal property test testing result.
4) Salmonella reversion test: blood fat reducing capsules A mes test result of the test is negative.
2. studies show that through Nanjing Medical University's (state food drug surveilance office assigned food health care detects unit) the blood fat reducing capsule has the effect of blood fat reducing.The result is as follows:
Estimate the effect that the blood fat reducing capsule is regulated rat fat with rat disorders of lipid metabolism modelling.The blood fat reducing capsule is irritated the laggard promoting the circulation of blood fat of stomach with the continuous 28d of the dosage (basic, normal, high dosage) of 167mg/kg, 333mg/kg, 1000mg/kg and is measured.The result shows that high, medium and low dosage group rat blood serum triglyceride levels is starkly lower than high fat matched group.Low dose group rat blood serum cholesterol levels is starkly lower than high fat matched group.High, medium and low dosage group rat blood serum HDL-C level is apparently higher than high fat matched group.Therefore think that the blood fat reducing capsule has the effect of blood lipid regulation.
Show through clinical 50 routine human trials, take the blood fat reducing capsule, every day 2 times, each 2, triglyceride levels is obviously descended.Now lift two examples.
60 years old male old man is arranged, and former triglyceride is 5.6mmol/L, checks after one month through taking the blood fat reducing capsule, and this index is reduced to 0.9mmol/L.
Other has 58 years old women, and former triglyceride is 3.55mmol/L, and through taking the blood fat reducing capsule after two months, blood fat is reduced to 1.2mmol/L.
The specific embodiment
Elaborate below in conjunction with embodiment.
Embodiment 1
Component is by weight: 0.5 part of Radix Salviae Miltiorrhizae, 0.5 part of Fructus Crataegi, 0.5 part of ratio of Semen Cassiae are weighed, and clean, and the decocting that adds 5 times of weight of above-mentioned raw material boiled 1 hour, filter, get filtrate, so repeat 2 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 50 ℃ are dried by the fire to moisture and are lower than 3%, take out, be crushed to 60 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
Embodiment 2
Component is by weight: 1.5 parts of Radix Salviae Miltiorrhizaes, 1.5 parts of Fructus Crataegis, 1.5 parts of ratios of Semen Cassiae are weighed, and clean, and the decocting that adds 10 times of weight of above-mentioned raw material boiled 2 hours, filter, get filtrate, so repeat 3 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 70 ℃ are dried by the fire to moisture and are lower than 5%, take out, be crushed to 80 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
Embodiment 3
Component is by weight: 0.7 part of Radix Salviae Miltiorrhizae, 0.7 part of Fructus Crataegi, 0.7 part of ratio of Semen Cassiae are weighed, and clean, and the decocting that adds 5 times of weight of above-mentioned raw material boiled 1 hour, filter, get filtrate, so repeat 2 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 50 ℃ are dried by the fire to moisture and are lower than 3%, take out, be crushed to 60 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
Embodiment 4
Component is by weight: 1.2 parts of Radix Salviae Miltiorrhizaes, 1.2 parts of Fructus Crataegis, 1.2 parts of ratios of Semen Cassiae are weighed, and clean, and the decocting that adds 10 times of weight of above-mentioned raw material boiled 2 hours, filter, get filtrate, so repeat 3 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 70 ℃ are dried by the fire to moisture and are lower than 5%, take out, be crushed to 80 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
Embodiment 5
Component is by weight: 1 part of Radix Salviae Miltiorrhizae, 1 part of Fructus Crataegi, 1 part of ratio of Semen Cassiae are weighed, and clean, and the decocting that adds 8 times of weight of above-mentioned raw material boiled 1.5 hours, filter, get filtrate, so repeat 2 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 60 ℃ are dried by the fire to moisture and are lower than 4%, take out, be crushed to 70 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
Embodiment 6
Component is by weight: 1.2 parts of Radix Salviae Miltiorrhizaes, 0.9 part of Fructus Crataegi, 0.9 part of ratio of Semen Cassiae are weighed, and clean, and the decocting that adds 8 times of weight of above-mentioned raw material boiled 1.5 hours, filter, get filtrate, so repeat 2 times, merging filtrate, be concentrated into thick extractum after, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 60 ℃ are dried by the fire to moisture and are lower than 4%, take out, be crushed to 70 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
Claims (4)
1. blood fat reducing capsule or tablet is characterized in that its composition by weight is: 1 part in Monas cuspurpureus Went, 0.5～1.5 part of Radix Salviae Miltiorrhizae, 0.5～1.5 part of Fructus Crataegi, 0.5～1.5 part of Semen Cassiae.
2. a kind of blood fat reducing capsule according to claim 1 or tablet is characterized in that its composition by weight is: 1 part in Monas cuspurpureus Went, 0.7～1.2 part of Radix Salviae Miltiorrhizae, 0.7～1.2 part of Fructus Crataegi, 0.7～1.2 part of Semen Cassiae.
3. the preparation method of blood fat reducing capsule or tablet, it is characterized in that component is by weight: 0.5～1.5 part of Radix Salviae Miltiorrhizae, 0.5～1.5 part of Fructus Crataegi, 0.5～1.5 part of ratio of Semen Cassiae are weighed, clean, the decocting that adds 5～10 times of weight of above-mentioned raw material boiled 1～2 hour, filter, get filtrate, so repeat merging filtrate 2～3 times, after being concentrated into thick extractum, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 50～70 ℃ are dried by the fire to moisture and are lower than 3～5%, take out, be crushed to 60～80 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
4. the preparation method of a kind of blood fat reducing capsule according to claim 3 or tablet, it is characterized in that component is by weight: 0.7～1.2 part of Radix Salviae Miltiorrhizae, 0.7～1.2 part of Fructus Crataegi, 0.7～1.2 part of ratio of Semen Cassiae are weighed, clean, the decocting that adds 5～10 times of weight of above-mentioned raw material boiled 1～2 hour, filter, get filtrate, so repeat merging filtrate 2～3 times, after being concentrated into thick extractum, add 1 part of Monas cuspurpureus Went, stir, move into baking oven, 50～70 ℃ are dried by the fire to moisture and are lower than 3～5%, take out, be crushed to 60～80 orders, encapsulating capsule or add starch slurry and be pressed into tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100256550A CN1246014C (en) | 2004-06-25 | 2004-06-25 | Blood fat lowering capsule or tablet and its preparation |
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| CNB2004100256550A CN1246014C (en) | 2004-06-25 | 2004-06-25 | Blood fat lowering capsule or tablet and its preparation |
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| CN1593551A true CN1593551A (en) | 2005-03-16 |
| CN1246014C CN1246014C (en) | 2006-03-22 |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431529C (en) * | 2005-12-22 | 2008-11-12 | 王幺光 | Soft capsule for reducing blood fat and its preparing method |
| CN102552468A (en) * | 2011-12-28 | 2012-07-11 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicine composition for treating hyperlipidemia |
| CN102657719A (en) * | 2012-04-27 | 2012-09-12 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating hyperlipidemia |
| CN102763848A (en) * | 2012-08-10 | 2012-11-07 | 广东太阳神集团有限公司 | Health care product for lowering blood lipid and preparation process thereof |
| CN102885922A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation method of slimming drug |
| CN102885919A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation of slimming drug |
| CN102885923A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation method of slimming drug |
| CN102885918A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation method of slimming Chinese medicine preparation |
| CN102885920A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Slimming Chinese medicine preparation composition |
| CN103316106A (en) * | 2013-05-28 | 2013-09-25 | 湖北省中医院 | Danshan fat reducing granules and preparation method thereof |
| CN104206955A (en) * | 2014-08-17 | 2014-12-17 | 苟春虎 | Lycium ruthenicum tablet for reducing blood fat |
| CN104257793A (en) * | 2014-08-21 | 2015-01-07 | 杭州双马生物工程有限公司 | Cholestin and preparation method of cholestin |
| CN105685994A (en) * | 2016-02-04 | 2016-06-22 | 北京康仁堂药业有限公司 | Healthcare food capable of assisting in blood lipid reduction and preparation method and application of healthcare food capable of assisting in blood lipid reduction |
| CN109589356A (en) * | 2018-11-29 | 2019-04-09 | 天津市农业生物技术研究中心 | A kind of cassia seed composition with auxiliary lipid-lowering efficacy |
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2004
- 2004-06-25 CN CNB2004100256550A patent/CN1246014C/en not_active Expired - Fee Related
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100431529C (en) * | 2005-12-22 | 2008-11-12 | 王幺光 | Soft capsule for reducing blood fat and its preparing method |
| CN102885920A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Slimming Chinese medicine preparation composition |
| CN102885920B (en) * | 2011-07-18 | 2016-01-27 | 天士力制药集团股份有限公司 | A kind of Chinese medicine preparation compositions for losing weight |
| CN102885918B (en) * | 2011-07-18 | 2016-03-02 | 天士力制药集团股份有限公司 | A kind of preparation method of weight-reducing Chinese medicinal preparation |
| CN102885919B (en) * | 2011-07-18 | 2016-01-27 | 天士力制药集团股份有限公司 | A kind of preparation of slimming medicine |
| CN102885919A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation of slimming drug |
| CN102885923A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation method of slimming drug |
| CN102885918A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation method of slimming Chinese medicine preparation |
| CN102885923B (en) * | 2011-07-18 | 2016-01-20 | 天士力制药集团股份有限公司 | A kind of preparation method of Chinese medicine for losing weight |
| CN102885922B (en) * | 2011-07-18 | 2015-12-09 | 天士力制药集团股份有限公司 | A kind of preparation method of slimming medicine |
| CN102885922A (en) * | 2011-07-18 | 2013-01-23 | 天士力制药集团股份有限公司 | Preparation method of slimming drug |
| CN102552468A (en) * | 2011-12-28 | 2012-07-11 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicine composition for treating hyperlipidemia |
| CN102657719A (en) * | 2012-04-27 | 2012-09-12 | 中国人民解放军第三七一医院 | Chinese medicinal preparation for treating hyperlipidemia |
| CN102763848A (en) * | 2012-08-10 | 2012-11-07 | 广东太阳神集团有限公司 | Health care product for lowering blood lipid and preparation process thereof |
| CN103316106A (en) * | 2013-05-28 | 2013-09-25 | 湖北省中医院 | Danshan fat reducing granules and preparation method thereof |
| CN104206955A (en) * | 2014-08-17 | 2014-12-17 | 苟春虎 | Lycium ruthenicum tablet for reducing blood fat |
| CN104257793A (en) * | 2014-08-21 | 2015-01-07 | 杭州双马生物工程有限公司 | Cholestin and preparation method of cholestin |
| CN105685994A (en) * | 2016-02-04 | 2016-06-22 | 北京康仁堂药业有限公司 | Healthcare food capable of assisting in blood lipid reduction and preparation method and application of healthcare food capable of assisting in blood lipid reduction |
| CN109589356A (en) * | 2018-11-29 | 2019-04-09 | 天津市农业生物技术研究中心 | A kind of cassia seed composition with auxiliary lipid-lowering efficacy |
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| CN1246014C (en) | 2006-03-22 |
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