CN1582970A - 一种从蝼蛄中提取的抗肿瘤有效部位及制备方法 - Google Patents
一种从蝼蛄中提取的抗肿瘤有效部位及制备方法 Download PDFInfo
- Publication number
- CN1582970A CN1582970A CNA2004100251627A CN200410025162A CN1582970A CN 1582970 A CN1582970 A CN 1582970A CN A2004100251627 A CNA2004100251627 A CN A2004100251627A CN 200410025162 A CN200410025162 A CN 200410025162A CN 1582970 A CN1582970 A CN 1582970A
- Authority
- CN
- China
- Prior art keywords
- gryllotalpa
- effective site
- extracting
- preparation
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims description 14
- 238000000605 extraction Methods 0.000 title description 4
- 241001243087 Gryllotalpidae Species 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 241000241125 Gryllotalpa gryllotalpa Species 0.000 claims abstract description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 34
- 241001243091 Gryllotalpa Species 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 20
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 9
- 230000001476 alcoholic effect Effects 0.000 claims description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 206010039491 Sarcoma Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 239000003208 petroleum Substances 0.000 claims description 6
- 239000003495 polar organic solvent Substances 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 5
- 206010017758 gastric cancer Diseases 0.000 claims description 5
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 201000011549 stomach cancer Diseases 0.000 claims description 5
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 229940041181 antineoplastic drug Drugs 0.000 claims description 4
- 238000011084 recovery Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000005325 percolation Methods 0.000 claims description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract description 5
- 238000010298 pulverizing process Methods 0.000 abstract description 2
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 description 18
- 241001465754 Metazoa Species 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- 230000000259 anti-tumor effect Effects 0.000 description 7
- 201000007270 liver cancer Diseases 0.000 description 6
- 208000014018 liver neoplasm Diseases 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 208000008720 Bone Marrow Neoplasms Diseases 0.000 description 3
- 241001529936 Murinae Species 0.000 description 3
- 241000699660 Mus musculus Species 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 201000006491 bone marrow cancer Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000011580 nude mouse model Methods 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000000287 crude extract Substances 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000002562 urinalysis Methods 0.000 description 2
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 241000785585 Gryllotalpa africana Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000009911 Urinary Calculi Diseases 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100251627A CN100473388C (zh) | 2004-06-15 | 2004-06-15 | 一种从蝼蛄中提取的抗肿瘤有效部位及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100251627A CN100473388C (zh) | 2004-06-15 | 2004-06-15 | 一种从蝼蛄中提取的抗肿瘤有效部位及制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1582970A true CN1582970A (zh) | 2005-02-23 |
CN100473388C CN100473388C (zh) | 2009-04-01 |
Family
ID=34601170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100251627A Expired - Fee Related CN100473388C (zh) | 2004-06-15 | 2004-06-15 | 一种从蝼蛄中提取的抗肿瘤有效部位及制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100473388C (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102293785A (zh) * | 2011-08-29 | 2011-12-28 | 河南科技大学 | 一种昆虫或节肢动物次生代谢物的提取方法 |
CN101716192B (zh) * | 2010-01-07 | 2012-03-21 | 福建农林大学 | 一种利用高速逆流色谱分离中药蝼蛄药效学物质的方法 |
CN102526591A (zh) * | 2012-01-16 | 2012-07-04 | 殷永洲 | 一种治疗白血病的特效中草药组合物 |
CN109549956A (zh) * | 2017-09-25 | 2019-04-02 | 上海医药工业研究院 | 蝼蛄提取物在制备治疗脑胶质瘤药物中的应用 |
CN109568347A (zh) * | 2017-09-25 | 2019-04-05 | 上海医药工业研究院 | 一种蝼蛄提取物及其提取方法 |
CN109589340A (zh) * | 2017-09-29 | 2019-04-09 | 上海医药工业研究院 | 蝼蛄提取物在制备治疗三阴乳腺癌药物中的应用 |
CN109589341A (zh) * | 2017-09-29 | 2019-04-09 | 上海医药工业研究院 | 蝼蛄提取物及其制备方法 |
-
2004
- 2004-06-15 CN CNB2004100251627A patent/CN100473388C/zh not_active Expired - Fee Related
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101716192B (zh) * | 2010-01-07 | 2012-03-21 | 福建农林大学 | 一种利用高速逆流色谱分离中药蝼蛄药效学物质的方法 |
CN102293785A (zh) * | 2011-08-29 | 2011-12-28 | 河南科技大学 | 一种昆虫或节肢动物次生代谢物的提取方法 |
CN102293785B (zh) * | 2011-08-29 | 2012-12-12 | 河南科技大学 | 一种昆虫或节肢动物次生代谢物的提取方法 |
CN102526591A (zh) * | 2012-01-16 | 2012-07-04 | 殷永洲 | 一种治疗白血病的特效中草药组合物 |
CN109549956A (zh) * | 2017-09-25 | 2019-04-02 | 上海医药工业研究院 | 蝼蛄提取物在制备治疗脑胶质瘤药物中的应用 |
CN109568347A (zh) * | 2017-09-25 | 2019-04-05 | 上海医药工业研究院 | 一种蝼蛄提取物及其提取方法 |
CN109568347B (zh) * | 2017-09-25 | 2022-07-12 | 上海医药工业研究院 | 一种蝼蛄提取物及其提取方法 |
CN109549956B (zh) * | 2017-09-25 | 2022-07-12 | 上海医药工业研究院 | 蝼蛄提取物在制备治疗脑胶质瘤药物中的应用 |
CN109589340A (zh) * | 2017-09-29 | 2019-04-09 | 上海医药工业研究院 | 蝼蛄提取物在制备治疗三阴乳腺癌药物中的应用 |
CN109589341A (zh) * | 2017-09-29 | 2019-04-09 | 上海医药工业研究院 | 蝼蛄提取物及其制备方法 |
CN109589340B (zh) * | 2017-09-29 | 2022-07-12 | 上海医药工业研究院 | 蝼蛄提取物在制备治疗三阴乳腺癌药物中的应用 |
CN109589341B (zh) * | 2017-09-29 | 2022-07-12 | 上海医药工业研究院 | 蝼蛄提取物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100473388C (zh) | 2009-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1891240A (zh) | 一种含多种灵芝活性成分的中药组合物及其制备方法 | |
CN101012230A (zh) | 斑蝥酸钠的制备工艺 | |
CN1745843A (zh) | 一种抗癌中药复方制剂及其制备方法 | |
CN1425447A (zh) | 一种治疗小儿食积咳嗽的中药组合物及其制备方法 | |
CN1582970A (zh) | 一种从蝼蛄中提取的抗肿瘤有效部位及制备方法 | |
CN1219545C (zh) | 头花蓼提取物及其药物组合物制剂 | |
CN1806820A (zh) | 一种中药组合物及其制备方法和质量控制方法 | |
CN1868485A (zh) | 一种药物组合物及应用 | |
CN1857622A (zh) | 包含天麻和川芎有效成分的药物组合物及制剂 | |
CN1895220A (zh) | 20(R)-人参皂苷Rg3药用水溶性中间体及制备方法 | |
CN101433575B (zh) | 一种乌桕种子提取物及其制备方法 | |
CN1141101C (zh) | ***的药物及其制备方法 | |
CN1179726C (zh) | 柚皮苷在制备支持性治疗非典型性肺炎药物中的应用 | |
CN1698803A (zh) | 一种复方三七注射剂制剂及其制备方法 | |
CN1720948A (zh) | 红茴香滴丸及其制备方法 | |
CN1544032A (zh) | 一种具有抗癌活性的中药提取物和它的制备工艺及其应用 | |
CN1850837A (zh) | 9-(1, 3-苯并二恶茂基-5)-4-(β-D-吡喃葡氧基)-6,7-二甲氧基萘并[2, 3-C]呋喃-1[3H] 酮, 其制备方法和含有该化合物的药物组合物 | |
CN1301099C (zh) | 地龙滴丸及其制备方法 | |
CN101633661B (zh) | 制备斑蝥酸钠的工艺 | |
CN104257955A (zh) | 一种含有东北天南星的抗肝癌中药混合物及其生产方法 | |
CN1301100C (zh) | 胆木滴丸及其制备方法 | |
CN101053587A (zh) | 一种用于抗肿瘤的药物组合物及制备方法和质量控制方法 | |
CN1682821A (zh) | 复方半边莲滴丸及其制备方法 | |
CN108567753A (zh) | 都梁滴丸及其制备工艺 | |
CN1895314A (zh) | 一种美观抗碎的三七总皂苷冻干粉针剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO Free format text: FORMER OWNER: SHANGHAI AOLONG TECHNOLOGY DEVELOPMENT CO., LTD.; APPLICANT Effective date: 20060825 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20060825 Address after: 201203 92 Zhangjiang Road, Shanghai, Pudong New Area Applicant after: Shanghai Pharmaceutical Technology Development Co.,Ltd. Address before: 200433 No. 122-2, National Road, Shanghai Applicant before: Aolong Science and Technology Development Co.,Ltd. Shanghai Co-applicant before: Hou Jian Co-applicant before: Kong Deyun Co-applicant before: Dai Qiming |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY Free format text: FORMER OWNER: AOLONG SCIENCE + TECHNOLOGY DEVELOPMENT CO., LTD. OF SHANGHAI Effective date: 20130122 Owner name: AOLONG SCIENCE + TECHNOLOGY DEVELOPMENT CO., LTD. Free format text: FORMER OWNER: SHANGHAI MEDICINE SCIENCE + TECHNOLOGY DEVELOPING CO., LTD. Effective date: 20130122 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Wu Tong Inventor after: Kong Deyun Inventor after: Yang Peiming Inventor after: Dai Qiming Inventor before: Huang Junqin Inventor before: Wu Jianwen |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 201203 PUDONG NEW AREA, SHANGHAI TO: 200086 HONGKOU, SHANGHAI Free format text: CORRECT: INVENTOR; FROM: HUANG JUNQIN WU JIANWEN TO: WU TONG KONG DEYUN YANG PEIMING DAI QIMING Free format text: CORRECT: ADDRESS; FROM: 200086 HONGKOU, SHANGHAI TO: 200040 JING'AN, SHANGHAI |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130122 Address after: 200040 Beijing West Road, Shanghai, No. 1320, No. Patentee after: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY Address before: 200086 Shanghai city Hongkou District Zhoujiazui road 981 Lane 8, room 1001 Patentee before: Aolong Science and Technology Development Co.,Ltd. Shanghai Effective date of registration: 20130122 Address after: 200086 Shanghai city Hongkou District Zhoujiazui road 981 Lane 8, room 1001 Patentee after: Aolong Science and Technology Development Co.,Ltd. Shanghai Address before: 201203 Pudong New Area Zhangjiang Road, Shanghai, No. 92 Patentee before: Shanghai Pharmaceutical Technology Development Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090401 Termination date: 20180615 |
|
CF01 | Termination of patent right due to non-payment of annual fee |