CN1578756A - Process for the preparation of optically pure or enriched racemic tetralone - Google Patents

Process for the preparation of optically pure or enriched racemic tetralone Download PDF

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Publication number
CN1578756A
CN1578756A CNA028216113A CN02821611A CN1578756A CN 1578756 A CN1578756 A CN 1578756A CN A028216113 A CNA028216113 A CN A028216113A CN 02821611 A CN02821611 A CN 02821611A CN 1578756 A CN1578756 A CN 1578756A
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Prior art keywords
enantiomorph
sertraline
chirality
tetralone
mixture
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L·贝尔热
R·迪瓦尔
P·塔耶森
I·韦伯
A·维克
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Pfizer Products Inc
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Pfizer Products Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/79—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A process for producing substantially optically pure sertraline utilizes chromatographic separation on a solid stationary chiral phase of spherical clay particles having an interlayer containing an optically pure metal-organic complex, and a liquid mobile phase preferably containing at least methyl acetate. The liquid mobile phase is preferably free of acetonitrile. The process is operable at temperatures above 40 DEG C.

Description

The preparation method of the racemic modification Tetralone an intermediate of Sertraline of optical purity or enrichment
Background of invention
The present invention relates to a kind of chromatography separating method that obtains the optical purity Tetralone an intermediate of Sertraline, wherein the optical purity Tetralone an intermediate of Sertraline is as the intermediate of preparation optical purity Sertraline (sertraline).As U.S. Patent number 4,536,518,5,196,607,5,442,116 and 4,777,288 are discussed, and Sertraline is used for the synthetic left Lip river summer (Zoloft), and the latter is that a kind of medicine of treatment dysthymia disorders of recent listing all is incorporated herein by reference here.The multiple method for preparing Sertraline has been described in above-mentioned patent.Typically, in preparation method's last stages the separating step of Sertraline raceme mixture is arranged, this preparation method's drawback is that the unwanted enantiomorph of requirement experiences a few step treatment steps.If the Tetralone an intermediate of Sertraline of use enantiomer-pure to limit the generation of unwanted Sertraline enantiomorph, can be avoided last separating step as the starting raw material for preparing the optical purity Sertraline like this, such method is preferable methods and sizable benefit is arranged.
In order to produce the left Lip river summer (hydrochloride of Sertraline) with valid approach, need with Sertraline suitable-(1S, 4S) enantiomorph and suitable-(1R, 4R) Chiral Separation is opened.In the PCT of publication number WO99/57089 application, the method for producing enantiomer-pure or optically enriched Sertraline-Tetralone an intermediate of Sertraline with continuous chromatography has been described.The key of this method be polysaccharide chirality stationary solid phase that utilizes derivatize and the liquid-flow that preferably contains second cyanogen mutually.
Although the production route that obtains the optical purity Sertraline is arranged, this method utilizes the temperature limitation that will use at the chirality stationary solid phase more than 40 ℃.Second cyanogen is a kind of solvent of costliness, also because its toxicity is also unfavorable to environmental protection.High and may not have enough magnetisms economically with the production cost of such method to be used to prepare the method for optically pure Tetralone an intermediate of Sertraline.Therefore also to continue to seek with method low-cost and produce the Sertraline of optical purity or enrichment with the productivity of the best.
Summary of the invention
A kind of from the mixture of two kinds of Tetralone an intermediate of Sertraline enantiomorphs chromatographic separation obtain basically the method for the chirality Tetralone an intermediate of Sertraline of enantiomer-pure and comprise the liquid-flow that comprises at least a solvent phase is provided; A kind of chirality stationary solid phase that comprises the inorganic carrier that is loaded with optical purity metal-organic complex is provided; And the chromatographic separation mixture obtains the Tetralone an intermediate of Sertraline of at least a enantiomer-pure basically.The solvent that uses is selected from lower alcohol such as methyl alcohol, ethanol, propyl alcohol, Virahol, butanols; The acetic ester of above-mentioned alcohol and propionic ester; Ketone such as acetone, butanone, isopropyl methyl ketone; Ether such as ether, isopropyl ether, t-butyl methyl ether; Tetrahydrofuran (THF); Diox; Alkane such as pentane, hexane, heptane, hexanaphthene, suberane, benzene,toluene,xylene; Halogenated lower alkane hydrocarbon such as methylene dichloride, chloroform, chlorinated benzene, fluoridize lower paraffin hydrocarbons, second cyanogen and composition thereof.The mixture of solvent particular methanol and methyl acetate.The separation of mixture is preferably carried out under the temperature of the about 80EC of about 40EC-.In the inorganic carrier material (silica gel, clay etc.), the metallic cation of complexing is selected from metallic nickel, osmium, ruthenium, platinum, cobalt, iron, copper and chromium, and wherein the ruthenium positively charged ion of complexing is preferred.The organic moiety of metal-organic complex is made of nitrogenous aromatic heterocycle, and it can give complex compound with chirality.This class complex compound can obtain optically pure form from its racemic modification with known method.Preferred heterocycle is 2,2-dipyridyl and 1,10-phenanthrolene.The preferred spheric clay material of inorganic carrier.The particle diameter of inorganic carrier can be 5-30 μ m, also can accept hydrophobic treatment.In one embodiment, the liquid-flow that uses is supercutical fluid such as postcritical CO mutually 2And polar solvent is selected from methyl alcohol, ethanol, THF, ethylene dichloride, acetone, methyl acetate and ethyl acetate.Chromatographic process can be used the continuous chromatography of single-column chromatogram or multicolumn chromatography such as simulated moving bed chromatography or unsteady state.At least a in one embodiment pure basically Tetralone an intermediate of Sertraline enantiomorph is needed enantiomorph, and another enantiomorph of two kinds of enantiomorphs is unwanted enantiomorph in the mixture, and stationary solid phase has the chirality direction that can keep unwanted enantiomorph.
Use mobile being on good terms that contains methyl alcohol of no second cyanogen to be reduced to this and to help environmental protection.Use have the cationic clay carrier of optically active metal-organic complex in it can be the about 40-80 of higher temperature ℃ of down operation, bigger solubleness and higher productive rate are arranged in this temperature range and can not produce adverse influence Separation of Enantiomers.Compared with prior art, the present invention can obtain the Tetralone an intermediate of Sertraline of optical purity or enrichment with lower cost and higher productive rate with the environmental protection acceptable manner, can produce optically pure Sertraline with less treatment step.
Detailed description of the present invention
Method of the present invention can utilize any successive chromatographic process such as single-column chromatogram or the racemic Tetralone an intermediate of Sertraline of simulation moving-bed (SMB) chromatographic separation to produce the Tetralone an intermediate of Sertraline of optical purity or enrichment, and the Tetralone an intermediate of Sertraline of gained is used to produce Sertraline.When using the mobile bed chromatic method, preferred chromatographic process is at United States Patent (USP) the 6th, 136, and 198 have been described, can use a kind of continuous separation method of unsteady state here, and it can change the length of particular section pillar to raise the efficiency during chromatographic separation.
In arbitrary scheme, the method that obtains the Tetralone an intermediate of Sertraline of enantiomer-pure or optical purity enrichment has all been used one or more pillars that stationary solid phase is housed, it can be from the charging that contains mixture of enantiomers a kind of enantiomorph of preferentially adsorbed (the strong enantiomorph that keeps).Provide a plurality of ports so that introduce incoming mixture, introduce strippant liquid-flow phase, for removing the raffinate (raffinate) that contains second kind of enantiomorph (enantiomorph of more weak reservation), and for remove contain desorb the strong enantiomorph extracting solution (extract) that keeps.The preferred multicolumn chromatography that uses, it interconnects feed end and exit end.When exit end is connected with feed end, can provide successive recirculation, not need recirculation in the preferred method of the present invention.
Liquid-flow is selected from lower alcohol such as methyl alcohol, ethanol, propyl alcohol, Virahol, butanols mutually; The acetic ester of above-mentioned alcohol and propionic ester; Ketone such as acetone, butanone, isopropyl methyl ketone; Ether such as ethyl ether, isopropyl ether, t-butyl methyl ether; Tetrahydrofuran (THF); Diox; Alkane such as pentane, hexane, heptane, hexanaphthene, suberane, benzene,toluene,xylene; Halogenated lower alkane hydrocarbon such as methylene dichloride, chloroform, chlorinated benzene, fluoridize lower paraffin hydrocarbons and composition thereof.Under some environment, can use second cyanogen, but it generally not preferred solvent.
In above-mentioned multiple solvent, be preferably based on the liquid-flow phase of methyl acetate, it can be formed separately or formed by methyl acetate and above-named one or more solvent by methyl acetate.More preferably use methyl acetate or methanol/methyl acetate mixture.Most preferred liquid-flow is methanol/methyl acetate mutually, and its proportional range is 0-100, more preferably 70-30, and 85-15 most preferably.
This specific liquid-flow has advantage cheaply with respect to second cyanogen, low toxicity and suitable fully selected chirality stationary solid phase and temperature.
The chirality stationary solid phase is made of the inorganic carrier that is loaded with cationic optical purity metal-organic complex (silica gel, clay, zeolite etc.), and this metal-organic complex forms strong bonding with the silica gel negatively charged ion that is present on the solid support material.Preferably, the chirality stationary solid phase is made of the spheric clay particle, and this clay particle internal layer mixes the positively charged ion with ion-exchange performance.Preferably, the reagent with silanization carries out hydrophobic treatment to suppress the water expansion and to make stationary solid phase material energy waterproof and few contaminated influence during treating processes to material.A kind of like this stationary solid phase material is more durable, this extra wearing quality increased stationary phase work-ing life, improved efficient and productive rate with respect to the solid phase that is consumed.When the multiple changing factor of the relative treating processes of chirality solid had better elasticity and lower susceptibility, expectability extended working time.In addition, be that the chirality solid of basal component is on good terms and is being operated under about 80 ℃ temperature more than 40 ℃ with the clay, can significantly improve productive rate like this, especially with polysaccharide relatively the time.Temperature range can be at 0-100 ℃, and preferred range is 40 ℃-80 ℃, more preferably from about 50-60 ℃.
The spherical clay chromatographic separation material that one class is used as chirality solid phase in the present invention is at U.S. Patent number 5,145, and 578 are described.The spherical clay chromatographic separation material of hydrophobic treatment is described at Japanese Kokai No.8-201366.This class material is commercial can be available from Tokyo Shiseido Co.Ltd..
Carrier granule has the cationic internal layer of metal-organic complex, and wherein metal is selected from nickel, osmium, ruthenium, platinum, cobalt, iron, copper and chromium.In the embodiment preferred, metal complex is basal component with the ruthenium complex.For example, can use the spherical clay chiral separation material of a kind of CeramosphereRU-1 of being called, this material can be available from Shiseido.The spherical clay chiral separation material of spendable hydrophobic treatment is Ceramosphere RU-2, also can use ruthenium metal complex positively charged ion.Preferred RU-2 because it more waterproof more ability be subject to processing multiple changing factor in the process.
The particle diameter of spherical clay material is at least 5 microns, and more preferably up to about 50 microns, preferable range is about 10-30 micron.Also preferably material is handled so that it has selected chirality directive action, the Tetralone an intermediate of Sertraline that strong reservation least needs is so that reclaim the enantiomorph of needs from raffinate, it can help to obtain the required enantiomorph of higher degree, and the latter also at first breaks away from from post.In this case, more weak reservation/needed enantiomorph can be in raffinate stream reclaims with the optical purity of the 95-99.9% of expectation.Strong keep/unwanted enantiomorph be retained in the chirality solid mutually in, extract mutually with liquid-flow subsequently, be collected in the extracting solution stream.Might add in the charging to increase the ultimate production of this method with unwanted enantiomorph racemization and with it.
When using simulated moving bed process, the dynamic chromatography separating method of preferred unsteady state.Mean the variable chromatographic fractionation system of section length of use different time between import and outlet with the method for unsteady state, like this equivalent solid flow velocity import with export between be different.In the method for SMB, all imports are switched basically simultaneously with outlet, with the countercurrent flow between simulation liquid phase and the solid phase.In the unsteady state system, right and wrong switching simultaneously between import and the outlet, so that the length of section is asynchronous fixed.This method is at U.S. Patent number 6,136, is described in 198, is hereby incorporated by and is referred to as hereinafter " Varicol TM" method.
Compare with traditional SMB method, this method is produced the chirality Tetralone an intermediate of Sertraline of optically pure or enrichment with the amount and the higher purity of the solid phase of less pillar, minimizing.
In an embodiment of the present invention, used the Varicol of five post to six posts-four a variable section TMSystem has also used the liquid phase and the solid phase of above-mentioned selection simultaneously, and this system can be circulation or once-through operation more than 40 ℃ or 40 ℃ the time in temperature.The length of section changes during operation, and section has an average rather than fixed length in specific operation cycle.In another embodiment, used the VaricoI of three posts-three a variable section TMSystem, this system can not use in the SMB method, because simulated moving bed system must have four posts, four sections.In three posts or five column systems, reduced the material of solid phase, the output of acquisition and throughput capacity are comparable to or are better than traditional SMB method.
The mixture of selecting supercutical fluid and polar solvent in another embodiment of the present invention is as liquid phase, for example postcritical CO 2With the polar solvent that is selected from methyl alcohol, ethanol, THF, ethylene dichloride, acetone, methyl acetate and ethyl acetate.Generally contain 20% to 60% supercritical CO 2Can provide suitable liquid-flow mutually with a kind of mixing in the above-mentioned solvent.Use such solvent to make product and solvent reclaim easily.
Embodiment
4 following embodiment take the SMB method, though the invention is not restricted to above-mentioned SMB method.Yet these results are considered to use the representative of benefit that method of the present invention obtains.
Embodiment 1
Operating parameters
Chirality solid phase RU2-λ 27 μ m
Moving phase methyl acetate/methanol: 50/50v/v
Column length 11cm
Post I.D.:48mm
The quantity 6 of pillar
The concentration of charging: 12.5%w/v
Elution flow rate: 249ml/min
Charging flow velocity: 40ml/min
Flow velocity in the section 1: 425ml/min
The flow velocity of extracting solution: 237ml/min
The flow velocity of raffinate: 52ml/min
Period: 0.95min
Temperature: 50 ℃
Working pressure: 25bar
SMB performance (experimental scale)
The purity of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 98.8%
The recovery output of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 97.8%
The volume of required eluent (l/g enantiomorph): 0.102l/g as calculated
Production efficiency (kg enantiomorph every kg CSP every day) 3.0kg/kg CSP/ days
The inlet amount of handling (enantiomorph that kg reclaims) 2.05kg
The product amount of racemization (enantiomorph that the every kg of kg reclaims): 1.05kg
Embodiment 2
Operating parameters
Chirality solid phase RU2-λ 27 μ m
Moving phase methyl acetate/methanol: 50/50v/v
Column length 11cm
Post I.D.:48mm
The quantity 6 of pillar
The concentration of charging: 12.5%w/v
Elution flow rate: 261ml/min
Charging flow velocity: 50ml/min
Flow velocity in the section 1: 435ml/min
The flow velocity of extracting solution: 241ml/min
The flow velocity of raffinate: 70ml/min
Period: 0.95min
Temperature: 50 ℃
Working pressure: 25bar
SMB performance (experimental scale)
The purity of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 98.1%
The recovery output of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 92.4%
The volume of required eluent (l/g enantiomorph): 0.091l/g as calculated
Production efficiency (kg enantiomorph every kg CSP every day) 3.5kg/kg CSP/ days
The inlet amount of handling (enantiomorph that kg reclaims) 2.16kg
The inlet amount of racemization (enantiomorph that the every kg of kg reclaims): 1.16kg
Embodiment 3
Operating parameters
Chirality solid phase RU2-λ 17 μ m
Moving phase methyl acetate/methanol: 70/30v/v
Column length 8cm
Post I.D.:48mm
The quantity 6 of pillar
The concentration of charging: 20%w/v
Elution flow rate: 141ml/min
Charging flow velocity: 25ml/min
Flow velocity in the section 1: 255ml/min
The flow velocity of extracting solution: 134ml/min
The flow velocity of raffinate: 32ml/min
Period: 0.85min
Temperature: 50 ℃
Working pressure: 30bar
SMB performance (experimental scale)
The purity of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 99.5%
The recovery output of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 83.5%
The volume of required eluent (l/g enantiomorph): 0.068l/g as calculated
Production efficiency (kg enantiomorph every kg CSP every day) 3.8kg/kg CSP/ days
The inlet amount of handling (enantiomorph that kg reclaims) 2.4kg
The inlet amount of racemization (enantiomorph that the every kg of kg reclaims): 1.4kg
Embodiment 4
Operating parameters
Post: chirality solid phase RU2-λ 17 μ m
Moving phase methyl acetate/methanol: 70/30v/v
Column length 8cm
Post I.D.:48mm
The quantity 5 of pillar
The concentration of charging: 20%w/v
Elution flow rate: 176ml/min
Charging flow velocity: 35ml/min
Flow velocity in the section 1: 354ml/min
The flow velocity of extracting solution: 176ml/min
The flow velocity of raffinate: 35ml/min
Period: 0.60min
Temperature: 50 ℃
Working pressure: 35bar
SMB performance (experimental scale)
The purity of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 99.5%
The recovery output of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 75%
The volume of required eluent (l/g enantiomorph): 0.067l/g as calculated
Production efficiency (kg enantiomorph every kg CSP every day) 5.6kg/kg CSP/ days
The inlet amount of handling (enantiomorph that kg reclaims) 2.65kg
The inlet amount of racemization (enantiomorph that the every kg of kg reclaims): 1.65kg
Use VARICOL TM The embodiment 5 of method
Operating parameters
Post: chirality solid phase RL2-λ 17 μ m
Moving phase methyl acetate/methanol: 81/19v/v
Column length 8cm
Post I.D.:48mm
The quantity 6 of pillar
The mean number of each section pillar: 0.75/1.5/3.25/0.5
The concentration of charging: 25%w/v
The flow velocity of eluent: 220ml/min
The flow velocity of charging: 30ml/min
Flow velocity in the section 1: 365ml/min
The flow velocity of extracting solution: 205ml/min
The flow velocity of raffinate: 45ml/min
Period: 0.65min
Temperature: 50 ℃
Working pressure: 35bar
The Varical of experimental scale TMPerformance
The purity of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 99.5%
The recovery output of the enantiomorph of more weak reservation (S-Tetralone an intermediate of Sertraline %): 83%
The volume of required eluent (l/g enantiomorph): 0.071l/g as calculated
Production efficiency (kg enantiomorph every kg CSP every day) 5.6kg/kg CSP/ days
The inlet amount of handling (enantiomorph that kg reclaims) 2.4kg
The inlet amount of racemization (enantiomorph that the every kg of kg reclaims): 1.4kg
Table 1 summed up with the spheric clay material as chirality solid phase, under 40-60 ℃ the temperature, use methyl acetate/methanol wherein to contain the various test-results of operating under the methyl acetate of 30-65%, the pressure at about 5-78bar.Six post SMB methods (diameter is 48mm) are used for test.
Table 1
????No. Particle diameter (μ m) Temperature (CE) Methyl acetate (%) Pressure (bar) The racemic modification concentration of injecting (g/l)
????1 ????5 ????40 ????100 ???72 ??280
????2 ????5 ????40 ????90 ???74 ??260
????3 ????5 ????40 ????80 ??250
????4 ????5 ????40 ????75 ??200
????5 ????5 ????40 ????50 ???78 ??150
????6 ????10 ????55 ????70 ???17 ??260
????7 ????10 ????55 ????65 ???17 ??150
????8 ????10 ????55 ????50 ???16 ??200
????9 ????27 ????55 ????35 ???5 ??125
????10 ????27 ????50 ????35 ???5 ??100
????11 ????27 ????60 ????30 ???5 ??150
????12 ????27 ????55 ????30 ???5 ??125
????13 ????27 ????50 ????30 ???5 ??100
????14 ????27 ????40 ????30 ???5 ??90
????15 ????27 ????60 ????40 ???5 ??175
????16 ????27 ????55 ????40 ???5 ??125
????17 ????27 ????50 ????40 ???5 ??100
????18 ????27 ????50 ????45 ???5 ??100
????19 ????27 ????55 ????45 ???5 ??150
????20 ????27 ????55 ????50 ???5 ??175
????21 ????27 ????40 ????50 ???5 ??90
????22 ????27 ????50 ????50 ???5 ??125
????23 ????17 ????50 ????65 ???10 ??175
????24 ????17 ????50 ????60 ???10 ??175
????25 ????17 ????50 ????55 ???10 ??175
????26 ????17 ????50 ????50 ???10 ??175
????27 ????17 ????50 ????45 ???10 ??175
Table 1 (continuation)
????No. Bed long (cm) ????SMB( *) output (Kg/ days) Concrete production efficiency (Kg/Kg/ days) Purity
Raffinate (%) Extracting solution (%)
????1 ????1.50 ????3.90 ????23.93 ????99.26 ????99.37
????2 ????1.30 ????4.58 ????32.42 ????99.29 ????98.12
????3 ????1.30 ????4.74 ????33.56 ????99.19 ????99.30
????4 ????1.30 ????5.28 ????37.41 ????98.99 ????99.43
????5 ????1.30 ????3.48 ????24.67 ????99.53 ????99.89
????6 ????3.80 ????5.66 ????13.73 ????99.00 ????99.17
????7 ????4.00 ????4.55 ????10.47 ????99.12 ????99.17
????8 ????4.00 ????5.32 ????12.24 ????99.08 ????99.65
????9 ????12.00 ????3.70 ????2.84 ????99.41 ????99.43
????10 ????12.25 ????3.70 ????2.78 ????99.13 ????99.57
????11 ????10.75 ????4.23 ????3.62 ????99.16 ????99.47
????12 ????9.50 ????3.68 ????3.57 ????99.02 ????98.18
????13 ????12.00 ????3.65 ????2.80 ????99.23 ????99.45
????14 ????10.25 ????2.88 ????2.59 ????99.41 ????99.15
????15 ????11.25 ????4.60 ????3.77 ????99.09 ????99.49
????16 ????12.00 ????3.50 ????2.69 ????99.17 ????99.55
????17 ????13.00 ????3.47 ????2.46 ????99.16 ????99.33
????18 ????12.75 ????3.34 ????2.42 ????99.06 ????99.68
????19 ????12.25 ????3.35 ????2.52 ????99.19 ????99.48
????20 ????14.75 ????2.48 ????1.55 ????99.33 ????99.55
????21 ????13.50 ????2.92 ????1.99 ????99.32 ????98.93
????22 ????13.75 ????2.99 ????2.01 ????99.25 ????99.12
????23 ????5.90 ????8.30 ????12.95 ????99.20 ????98.93
????24 ????5.50 ????7.10 ????11.88 ????99.16 ????99.07
????25 ????5.50 ????8.06 ????13.50 ????99.21 ????99.32
????26 ????5.50 ????8.17 ????13.69 ????99.28 ????99.41
????27 ????5.10 ????6.66 ????12.03 ????99.35 ????98.95
From embodiment 1-5 and table 1 as can be seen, when in high relatively temperature, can obtain highly purified enantiomorph with solvent that reduces and the production efficiency that increases during operation more than 40 ℃.Utilize the Varicol of unsteady state TMChromatography separating method can cause production efficiency further to improve because the consumption of stationary solid phase since the optimizing of post number can reduce.
Other solvent that can be used for the inventive method illustrates as an example lists in following table 2.
Table 2
????C.P.S. Solvent 1 ％ Solvent 2 ????％ Temperature (℃) The peak width at two peaks (min) Injection rate (mg) Production efficiency (kg/kgcps/ days)
????RU-1 Second cyanogen 100 ??- ????0 ????30 3.4 ??123 ???132
????″ Acetone 100 ??- ????0 ????40 2 ??12 ???2.16
????″ Ethyl acetate 100 ??- ????0 ????40 45 ??50 ???4.00
????″ Ethyl acetate 100 ??- ????0 ????60 4 ??50 ???4.5
????″ 2-butanone 100 ??- ????0 ????40 2 ??10 ???1.80
????″ Ethyl acetate 75 Methyl alcohol ????25 ????40 4.5 ??50 ???4.00
????″ Ethyl acetate 50 Methyl alcohol ????50 ????40 8 ??70 ???3.15
????RU-2 2-butanone 100 ??- ????0 ????40 1.4 ??25 ???6.43
????″ 2-butanone 75 Methyl alcohol ????25 ????40 2 ??40 ???7.20
????″ 2-butanone 25 Methyl alcohol ????75 ????40 11 ??112 ???3.67
????″ Ethanol 100 ??- ????0 ????40 15 ??80 ???1.92
????″ Ethanol 25 Ethyl acetate ????75 ????40 1.9 ??25 ???4.74
Utilize the supercutical fluid mixture can further be increased, though handle having relatively high expectations of supercutical fluid required equipment as liquid-flow phase time production efficiency.
Utilize per 5 minutes with 30% supercritical CO 2The racemic modification that the liquid phase that constitutes with 70% ethyl acetate is injected the 140mg of HPLC post is assessed the increase of productive rate.Employed stationary solid phase is Ceramospher Ru-1.According to surveying and determination with use methyl acetate/methanol and Ceramospher RU-2 relatively, the amount of the raceme of purifying will be 7.3 kilograms of every liter of upholders every day.The model that the embodiment that HPLC analyzes is considered to represent meaning and is used as the SMB method can be used to predict production efficiency.Its test-results is listed in following table 3:
Table 3
Overcritical ????HPLC
The solid phase (CPS) of pillar ????Ru-1 ????Ru-2
Diameter ????4.6mm ????4.6mm
Length ????25cm ????25cm
Granularity ????5μm ????5μm
Solvent ????CH 3COOC 2H 5/CO 2 ????CH 3COOCH 3/CH 3OH
Ratio ????70/30 ????80/20
Pressure ????150bar ????70bar
Temperature ????50℃ ????40℃
Productive rate 7.3kg/kg charging/sky 4.3kg/kg charging/sky
By using RU-1 and need not use the result of RU-2 all the same during postcritical model as the liquid-flow phase time with the supercutical fluid mixture more as can be seen.Its production efficiency is at least double and does not also utilize VaricoI when overcritical model manipulation TMMethod is further improved.Therefore, most economical terms of settlement may be to utilize the supercutical fluid mixture.Yet, benefit of the present invention be obtained and supercutical fluid needn't be used, because use clay material such as RU-2 and above-mentioned liquid phase and method just can obtain sizable improvement, and be used for the required extra equipment of supercutical fluid and here do not need.
The invention provides a kind of be used for producing optically pure Sertraline (sertraline) thus the production method of optical purity Tetralone an intermediate of Sertraline of intermediate avoided the chiral separation of final stage Sertraline (sertraline), this method with a kind of can be at high temperature, promptly the chromatography separating method of operation is produced the optical purity Tetralone an intermediate of Sertraline to improve separation efficiency more than 40 ℃.The liquid-flow that the present invention preferentially uses no second cyanogen mutually with pollutent such as water or acid are had mutually than Wheat Protein and the chirality solid that do not have a polysaccharide.Randomly, utilize the mobile bed chromatic of unsteady state to reduce the amount of chirality solid phase and make processing efficiency the best by the length that between separation period, dynamically changes bed.In another embodiment, with supercutical fluid as the part of liquid-flow phase obtain optical purity or enrichment Tetralone an intermediate of Sertraline.
The present invention has shown and has described embodiment preferred that those skilled in the art can understand in not departing from scope of the present invention can carry out multiple change and variation to it.

Claims (17)

1. chromatogram is resolved the method for the chirality Tetralone an intermediate of Sertraline of enantiomer-pure basically from the mixture of two kinds of Tetralone an intermediate of Sertraline enantiomorphs, and it comprises:
The liquid-flow that comprises at least a solvent phase is provided;
The chirality that comprises the inorganic carrier with optical purity metal-organic complex stationary solid phase is provided; And
The chromatographic separation mixture obtains the Tetralone an intermediate of Sertraline of at least a enantiomer-pure basically.
2. the described method of claim 1, further selective solvent wherein comprises from lower alcohol such as methyl alcohol, ethanol, propyl alcohol, Virahol, butanols; The acetic ester of above-mentioned alcohol and propionic ester; Ketone such as acetone, butanone, isopropyl methyl ketone; Ether such as ether, isopropyl ether, t-butyl methyl ether; Tetrahydrofuran (THF); Diox; Alkane such as pentane, hexane, heptane, hexanaphthene, suberane, benzene,toluene,xylene; Halogenated lower alkane hydrocarbon such as methylene dichloride, chloroform, chlorinated benzene, fluoridize selective solvent in lower paraffin hydrocarbons, second cyanogen and composition thereof.
3. the described method of claim 1, wherein being separated under the about 40 ℃-Yue 80 ℃ temperature of mixture carried out.
4. the described method of claim 2, wherein solvent is the mixture of methyl alcohol and methyl acetate.
5. the described any method of claim 1-4, wherein the metal complex positively charged ion is selected from metallic nickel, osmium, ruthenium, platinum, cobalt, iron, copper and chromium.
6. the described method of claim 5, wherein the metal complex positively charged ion is the ruthenium complex cation.
7. the described any method of claim 1-4, wherein the chirality stationary solid phase comprises the spherical clay material that hydrophobic treatment is crossed.
8. the described any method of claim 1-4, wherein the particle diameter of chirality stationary solid phase is the about 30 μ m of about 5-.
9. the described any method of claim 1-4, wherein liquid-flow further comprises supercutical fluid mutually.
10. the described any method of claim 1-4, wherein liquid-flow contains postcritical CO mutually 2And solvent is the polar solvent that is selected from methyl alcohol, ethanol, THF, methylene dichloride, acetone, methyl acetate and ethyl acetate.
11. the described any method of claim 1-4 further comprises with single-column chromatographic separation mixture.
12. the described any method of claim 1-4 further comprises with mimic mobile bed chromatic chromatographic separation mixture.
13. the described any method of claim 1-4 further comprises the unstable state continuous chromatography chromatographic separation mixture with multicolumn.
14. the described any method of claim 1-4, wherein at least a pure basically Tetralone an intermediate of Sertraline enantiomorph is the preferred enantiomorph of institute, and another enantiomorph in two kinds of mixture of enantiomers is unwanted enantiomorph, and further comprises the stationary solid phase with the chirality direction that can keep unwanted enantiomorph is provided.
15. the described any method of claim 1-4, wherein metal-organic complex has nitrogenous heterocyclic organic ligand, and this part is given metal-organic complex with chirality.
16. the described method of claim 15, wherein organic ligand is 2, the 2-dipyridyl.
17. the described method of claim 15, wherein organic ligand is 1, the 10-phenanthrolene.
CNA028216113A 2001-10-31 2002-09-27 Process for the preparation of optically pure or enriched racemic tetralone Pending CN1578756A (en)

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