CN1562003A - Compound metrinizole cream - Google Patents
Compound metrinizole cream Download PDFInfo
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- CN1562003A CN1562003A CN 200410018750 CN200410018750A CN1562003A CN 1562003 A CN1562003 A CN 1562003A CN 200410018750 CN200410018750 CN 200410018750 CN 200410018750 A CN200410018750 A CN 200410018750A CN 1562003 A CN1562003 A CN 1562003A
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- metronidazole
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Abstract
A compound metronidazole cream for treating acne, acne-type dermatitis, various dermatitis, eczema, tinea, etc contains metronidazole powder, mycosporin powder, zinc oxide powder, chlorpheniramine, medical glycerine, almond oil, cream matrix, water VE, nitrone, and essence.
Description
Technical field
The present invention relates to a kind of medicine, relate in particular to the dermopathic medicine of a kind of treatment.
Background technology
Make at present apply some make up very general, especially joint venture, emporium, the owner requires that the employee is on duty must to be made up, particularly the women salesman is more unexceptional.In the course of time cause that the cosmetics contact dermatitis occurs in a large number.At present, the dermatitis that the treatment cosmetics cause, the emulsifiable paste classes that contain the hormone composition that adopt as omcilon frost, PIYANPING, PIKANGWANG etc. more.Though still good with the back effect, with can producing dependency after a period of time or cause corticosteroid dermatitis, gently then influence beauty treatment, heavy then disfeature, bring misery to the patient.
Summary of the invention
The objective of the invention is to, provide a kind of and both can treat various dermatosiss, the compound metronidazole cream that can avoid producing dependency again or cause the phenomenon of corticosteroid dermatitis to take place.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of compound metronidazole cream comprises following component by weight:
Metronidazole powder 10-20, clotrimazole powder 10-20, oxide powder and zinc 10-35, chlorpheniramine powder 10-25, medical glycerol 50-100, almond oil 30-100, medical emulsifiable paste matrix 1000-2500.
Can also comprise Mel 30-60, aqueous V by weight in the said components
E20-40; Azone 0.2-0.5;
In said components, can also comprise an amount of essence by weight.
Nearly all dermatosis such as dermatitis, tinea class, acne majority cause that by anaerobe or fungal infection gargalesthesia is arranged more, and the resistance of local skin of a specified duration own weakens, and sensitivity strengthens, and acute gargalesthesia is arranged, even local rubescent oozing out.In the metronidazole cream of the present invention, metronidazole has the anaerobe resistant effect, and sarcoptic mite, acarid are had stronger killing action.Clotrimazole has broad-spectrum antibacterial action, and Mycophyta is had tangible killing action.Use chlorphenamine and then make the local sensitivity reduction, have itching-relieving action.Simultaneous oxidation zinc has then played the protective effect to skin, and convergence skin makes it ooze out minimizing.In antiinflammatory, germ-resistant while, also added the material that skin is had reparation and Nutrition in the emulsifiable paste of the present invention.Almond oil and aqueous V
EBoth played the effect of lubricious skin, mottle is disappeared, also nutritious and protective effect.Glycerol can make skin wet, can other drug is penetrated in the epidermis with the azone synergism again and work.Mel contains several amino acids and saccharide, contains a small amount of colloidal substance again, plays the effect of reparation, skin nutrition.
Do not contain hormonal substance in the emulsifiable paste of the present invention, life-time service does not have dependency.
Compound preparation of the present invention is applicable to acne and acne sample dermatitis, cosmetics contact dermatitis, corticosteroid dermatitis, all kinds of eczema, acute and chronic dermatitis, acarid dermatitis, fungus-caused tinea, tinea capitis, tinea corporis, tinea manus and pedis etc.
The specific embodiment
Emulsifiable paste of the present invention mainly comprises the powder class of being made up of metronidazole powder, clotrimazole powder, oxide powder and zinc and chlorpheniramine powder, the liquid type of being made up of medical glycerol and almond oil, and medical emulsifiable paste matrix.Nutrition and elasticity in order to increase skin can add Mel, aqueous V in emulsifiable paste
E, form liquid type jointly with medical glycerol and almond oil.Can increase the adjuvant class as required in addition,, add an amount of essence as fragrance according to needs; In order to increase transdermal characteristic, add proper N copper.That the powder class has is antibiotic, antiinflammatory, desensitization, exfoliation effect.The effect that liquid type has skin moistening, decontamination, brightens, preserves moisture.
Metronidazole, clotrimazole, zinc oxide and four kinds of medicated powder of chlorphenamine are mixed in proportion the back add in the liquid type and make pasty state, add medical emulsifiable paste matrix and adjuvant class again, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 1:
With metronidazole powder 10 grams, clotrimazole powder 10 grams, oxide powder and zinc 10 grams, chlorpheniramine powder 10 grams, put into the liquid of being made up of medical glycerol 50 gram, almond oil 30 grams and make pasty state, add medical emulsifiable paste matrix 1000 again and restrain, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 2:
With metronidazole powder 15 grams, clotrimazole powder 15 grams, oxide powder and zinc 20 grams, chlorpheniramine powder 18 grams are put into by medical glycerol 75 grams, make pasty state in the liquid that almond oil 70 grams are formed, add medical emulsifiable paste matrix 2000 grams again, essence 0.5 gram, azone 0.3 gram, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 3:
With metronidazole powder 20 grams, clotrimazole powder 20 grams, oxide powder and zinc 35 grams, chlorpheniramine powder 25 grams are put into by medical glycerol 100 grams, make pasty state in the liquid that almond oil 100 grams are formed, add medical emulsifiable paste matrix 2500 grams again, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 4:
With metronidazole powder 10 grams, clotrimazole powder 10 grams, oxide powder and zinc 10 grams, chlorpheniramine powder 10 grams are put into by medical glycerol 50 grams, almond oil 30 grams, Mel 30 grams, aqueous V
EMake pasty state in the liquid that 20 grams are formed, add medical emulsifiable paste matrix 1000 grams again, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 5:
With metronidazole powder 20 grams, clotrimazole powder 20 grams, oxide powder and zinc 35 grams, chlorpheniramine powder 25 grams are put into by medical glycerol 100 grams, almond oil 100 grams, Mel 60 grams, aqueous V
EMake pasty state in the liquid that 40 grams are formed, add medical emulsifiable paste matrix 25 00 grams again, essence 0.3 gram, azone 0.2 gram, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 6:
With metronidazole powder 18 grams, clotrimazole powder 16 grams, oxide powder and zinc 30 grams, chlorpheniramine powder 14 grams are put into by medical glycerol 85 grams, almond oil 80 grams, Mel 50 grams, aqueous V
EMake pasty state in the liquid that 35 grams are formed, add medical emulsifiable paste matrix 1800 grams again, essence 0.2 gram, azone 0.4 gram, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 7:
With metronidazole powder 12 grams, clotrimazole powder 15 grams, oxide powder and zinc 18 grams, chlorpheniramine powder 20 grams are put into by medical glycerol 75 grams, almond oil 60 grams, Mel 45 grams, aqueous V
EMake pasty state in the liquid that 30 grams are formed, add medical emulsifiable paste matrix 1500 grams again, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Embodiment 8:
With metronidazole powder 12 grams, clotrimazole powder 14 grams, oxide powder and zinc 18 grams, chlorpheniramine powder 15 grams are put into by medical glycerol 80 grams, make pasty state in the liquid that almond oil 80 grams are formed, add medical emulsifiable paste matrix 1800 grams again, essence 0.6 gram, azone 0.5 gram, the colloid mill of putting into granularity and being about 200 orders grinds to form cream.
Use compound metronidazole cream clinical experiment report of the present invention:
The case choice criteria:
1. long-term external corticosteroid hormone medicine medical history is arranged.
2. the corticosteroid hormone rebound phenomenon is arranged or rely on history.
3. conscious pruritus or burning sensation.
4. pleomorphism skin lesion performance: diffuse erythema, blood rash, telangiectasis, dry desquamation, pigmentation etc.
Therapeutic Method:
Stopping using, all contain the external used medicine of corticosteroid hormone, use compound metronidazole cream of the present invention to wipe outward, and twice or three times of every day, ten days is a course of treatment, four the course of treatment observe the curative effect.The obvious person of pruritus adds antihistaminic cetirizine 10mg, once a day, and the cold wet compress of external Cortex Phellodendri fluid, every day three times, each 20 minutes.
Clinical data:
Patient age 18-53 year, women's 66 examples wherein, male's 6 examples, the course of disease is the shortest 6 months, and is the longest 8 years.Once treating disease has acne, schlempe dermatitis, cosmetic dermatitis, seborrheic dermatitis etc., and medication has medicines such as omcilon frost, beclometasone frost, cremor halcinonidi, PIYANPING, PIKANGWANG.
18 examples of fully recovering, subjective symptoms disappears, and skin lesion all disappears, and does not have recurrence in 1 month.
Produce effects 34 examples, subjective symptoms disappears substantially, and skin lesion disappears had recurrence by chance in 70%, 1 month.
Effective 16 examples, subjective symptoms obviously alleviates, the skin lesion 20-70% that disappears.
Invalid 4 examples, subjective symptoms does not have obvious improvement, the skin lesion less than 20% that disappears.
Obvious effective rate 72.2%, total effective rate 94.4%.
Although relate to a kind of compound metronidazole cream and carried out special description disclosed with reference to embodiment, those skilled in the art can understand, under the situation that does not depart from scope and spirit of the present invention, can carry out all conspicuous modification of form and details to it.Therefore, embodiment described above is illustrative and not restrictive, and under the situation that does not break away from the spirit and scope of the present invention, all variations and modification are all within the scope of the present invention.
Claims (3)
1. a compound metronidazole cream is characterized in that, comprises following component by weight:
Metronidazole powder 10-20, clotrimazole powder 10-20, oxide powder and zinc 10-35, chlorpheniramine powder 10-25, medical glycerol 50-100, almond oil 30-100, medical emulsifiable paste matrix 1000-2500.
2. compound metronidazole cream according to claim 1 is characterized in that, comprises following component by weight:
Metronidazole powder 10-20, clotrimazole powder 10-20, oxide powder and zinc 10-35, chlorpheniramine powder 10-25, medical glycerol 50-100, almond oil 30-100, Mel 30-60, aqueous V
E20-40, medical emulsifiable paste matrix 1000-2500, azone 0.2-0.5.
3. compound metronidazole cream according to claim 2 is characterized in that, comprises following component by weight:
Metronidazole powder 10-20, clotrimazole powder 10-20, oxide powder and zinc 10-35, chlorpheniramine powder 10-25, medical glycerol 50-100, almond oil 30-100, Mel 30-60, aqueous V
E20-40, medical emulsifiable paste matrix 1000-2500, azone 0.2-0.5, essence is an amount of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410018750 CN1562003A (en) | 2004-03-16 | 2004-03-16 | Compound metrinizole cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410018750 CN1562003A (en) | 2004-03-16 | 2004-03-16 | Compound metrinizole cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1562003A true CN1562003A (en) | 2005-01-12 |
Family
ID=34479509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410018750 Pending CN1562003A (en) | 2004-03-16 | 2004-03-16 | Compound metrinizole cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1562003A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2899475A1 (en) * | 2006-04-10 | 2007-10-12 | Galderma Res & Dev | Composition, useful to prepare a drug to treat and/or the prevent rosacea, preferably vascular disorders caused by rosacea, comprises metronidazole and zinc, in a medium |
| CN113456668A (en) * | 2021-05-27 | 2021-10-01 | 齐万琴 | External ointment for women and preparation method thereof |
-
2004
- 2004-03-16 CN CN 200410018750 patent/CN1562003A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2899475A1 (en) * | 2006-04-10 | 2007-10-12 | Galderma Res & Dev | Composition, useful to prepare a drug to treat and/or the prevent rosacea, preferably vascular disorders caused by rosacea, comprises metronidazole and zinc, in a medium |
| CN113456668A (en) * | 2021-05-27 | 2021-10-01 | 齐万琴 | External ointment for women and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |