CN1539433A - Tincture for curing acne and preparation method - Google Patents
Tincture for curing acne and preparation method Download PDFInfo
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- CN1539433A CN1539433A CNA031133002A CN03113300A CN1539433A CN 1539433 A CN1539433 A CN 1539433A CN A031133002 A CNA031133002 A CN A031133002A CN 03113300 A CN03113300 A CN 03113300A CN 1539433 A CN1539433 A CN 1539433A
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Abstract
A tincture for treating acne is prepared from leucomycin, salicylic acid and 6 Chinese-medicinal materials including dahurian angelica root, pearl powder, borneol, etc. Its advantages are sure curative effect, quickly taking its effect and no toxic by-effect.
Description
Technical field:
The present invention relates to tincture for the treatment of acne and preparation method thereof.
Background technology:
Acne are being commonly called as of acne, have another name called skin sore, comedo etc.It is a kind of common cyst dermatosis that occurs in 15-30 between twenty and fifty human face about year, mainly occurs in face, secondly is chest and back.The men and women all can be taken place, and very influences face appearance, and severe patient can make appearance damage, and forms the facial speckle that lifelong difficulty heals.Doctor trained in Western medicine thinks that the cause of acne is because vigorous, drainage difficulty of adolescence smegma or acarid breeding and hair follicle stopped up cause the permeability of skin to weaken.Excrete poison because of acarid again and the pungent stimulation food of polyphagia causes chronic multiple folliculitis and seborrheic dermatitis, be acne.The traditional Chinese medical science thinks because the showing tremendous enthusiasm upper punch of lung stomach damp is fumigated face, fights mutually to tie in skin with the wind heat damp in the external world and fall ill.Cause the factor of lung and gastrointestinal pathogenic heat to have two: one, human body, is easy to give birth to heat and gets angry on the occasion of in postcoital protrusion fire contains the table postadolescence; The 2nd, the pungent delicious food of surfeit etc. is easy to the dry property of Sheng Refa food.
Present Therapeutic Method comprises:
For oral administration Western medicine, particularly endocrine regulation and hormones product, less being used owing to there is the side effect that is difficult to avoid.
Oral Chinese medicine: as heat clearing away toxin expelling class, its advantage is to solve problem from the balance angle of the traditional Chinese medical science, but shortcoming is also clearly, and the one, it is slow to take effect, and is difficult to get instant result; The 2nd, need take for a long time, spend bigger.
Externally-applied liniment: adopt the local skin administration, Transdermal absorption is simple and direct effective.This is comparatively popular in the world method of going acne.But general frost, unguentum product are excessive because of molecule, are difficult to see through organizational structure keratodermatitis closely, and transdermal absorption factor is low, is difficult to go deep into the acne root, and frost, unguentum product are improper as using, and also can cause pore to stop up, and increase the weight of the development of acne.
Summary of the invention:
Technical problem to be solved by this invention is to avoid existing weak point in the above-mentioned prior art, provides a kind of and produces effects rapidly, the tincture of determined curative effect, non-sensitization, nonirritant, the treatment acne that have no side effect.And provide the preparation method of this tincture.
The technical scheme that technical solution problem of the present invention is adopted is:
The characteristics that the present invention treats the tincture of acne are:
It mainly is to make: Radix Angelicae Dahuricae 10-30 part, Margarita powder 10-50 part, Semen Armeniacae Amarum 10-30 part, Semen Ginkgo core 10-80 part, Bulbus Fritillariae Cirrhosae 10-30 part, Borneolum Syntheticum 10-30 part, chloromycetin 5-30 part, salicylic acid 5-30 part by following bulk drugs.
In order to reach better therapeutic, crude drug wherein can also add: dexamethasone 0.01-0.03 part.
The characteristics of preparation method that the present invention treats the tincture of acne are: have following steps:
A, get the Radix Angelicae Dahuricae, Semen Ginkgo core, Semen Armeniacae Amarum and Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, with the Margarita powder mixing, be equipped with in the lid container, add the ethanol of 50-80%, alcoholic acid addition was to cover medicine, enough to soak into degree of being, airtight immersion 7 days is stirred 2 every day, filtration;
Add Borneolum Syntheticum, chloromycetin, salicylic acid in b, the filtrate, stir and make it dissolving;
C, adjusting pH value are 3.0-5.0;
The ethanol adjustment of d, usefulness 50-80% makes it contain the alcohol amount and is 65%-75%;
E, stir evenly, leave standstill, filtration, fill, check, packing promptly.
Character: this product is faint yellow to amber supernatant liquid, and postpone for a long time has microprecipitation, gas fragrance.
Function with cure mainly: heat clearing and inflammation relieving, sterilizing and itch-relieving, profit flesh skin care.Be used for the treatment of acne, rosacea.
Usage and consumption: the warm water cleaning affected part, dry, dip in liquid medicine and evenly embrocate the affected part.3-4 time on the one.
Tincture of the present invention be based on dispeling the wind skin moistening, heat clearing and inflammation relieving, causing resuscitation with aromatic drugs, women's head-ornaments that loose are hot and suffocating, and clean skin and the method for tissue regeneration promoting.
Active component has the blood circulation of improvement in the Radix Angelicae Dahuricae, and blood vessel dilating and antiinflammation can make that facial muscle are plentiful, skin is ruddy.
Margarita contains several amino acids and trace element, is longer than moist skin, is coated with brothers and removes the peel the skin hangnail.
Semen Armeniacae Amarum contains amygdaloside, fatty oil, protein and several amino acids.Semen Armeniacae Amarum oil has inhibitory action to ancylostome, ascarid and Bacillus typhi, Salmonella paratyphi etc.
Bulbus Fritillariae Cirrhosae contains multiple alkaloid, and the Bulbus Fritillariae Uninbracteatae total alkali has antiulcer action, also has effect calm, analgesia.
Borneolum Syntheticum contains multiple ter penoids, has the refreshment of having one's ideas straightened out, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, eliminating fire and detoxication, the removing nebula effects such as strongly fragrant skin moistening that make eye bright, loose.
Semen Ginkgo core contains protein, fat, starch, vitamin B2 and several amino acids.In vitro tests has in various degree inhibitory action to various bacteria and dermatophytes.Some active component can stop the age pigment granule of Aged Mice spleen tissue to form, and makes dispersions that become of established pigment granule, the quantity minimizing, thereby have antidotal effect.
Chloromycetin belongs to the amide-type antibiotic, and has a broad antifungal spectrum is easily molten in methanol, ethanol, acetone.
Salicylic acid has antifungal, antipruritic, effect such as dissolving cutin etc.External is embrocated and is used for seborrhea, seborrheic dermatitis, scurf disease, superficial mycosis wart, clavus, Zhi and local hyperkeratosis.
Be monarch with the Radix Angelicae Dahuricae among the side of the present invention, fragrance dispels the wind to separate damp with the stagnated fire of loosing, be " head is all firm meeting, only wind and do not reach " the wind medicine hot damp and hot strongly fragrant to dispel the wind in the method for treatment of women's head-ornaments; The heat of joining Margarita lung heat clearing stomach two warps, profit skin are with tissue regeneration promoting, and Semen Armeniacae Amarum removes lung-heat, subsides a swelling, goes face all wind Zha bleb and the diffusing lung meridian accumulation of heat of Bulbus Fritillariae Cirrhosae and can restrain the open sore part is minister; Semen Ginkgo core, Borneolum Syntheticum use for making, the kind lung heat clearing of Semen Ginkgo core is through stagnated fire, external especially can " be gone the Zha bleb ", Borneolum Syntheticum guides all medicines straight saturating myonosus institute.With salicylic acid, chloromycetin anti-inflammation, assistant Chinese medicine is with the clean skin that detoxifies.
Compared with the prior art, beneficial effect of the present invention is embodied in:
1, tincture of the present invention can suppress corynebacterium and staphylococcus effectively, chloromycetin wherein and salicylic acid can be worked in coordination with the effect that Chinese medicine plays bactericidal antiphlogistic, and salicylic acid can dissolution angular embolization, promotes the drainage of sebum, reduce gathering of follicular orifice sebum, thereby stoped the generation of acne.Produce effects rapidly, determined curative effect by acne for treating for tincture of the present invention, and general acne have 85-90% promptly effective in cure in three days, and the cure rate of serious acne patient after treatment in 15-30 days reaches more than 80%, and the total effective rate of treatment acne is 98%.We are little to the stimulation of skin, and the skin peeling degree is very slight, no obvious toxic-side effects.
2, preparation process of the present invention is according to the dermatosis traditional habit, relatively afterwards determines in test of many times.The Radix Angelicae Dahuricae, Bulbus Fritillariae Cirrhosae, Margarita powder, Semen Ginkgo core etc. contain pure soluble components such as multiple glycoside, alkaloid, coumarin, protein and several amino acids in the side, therefore, adopting ethanol is the infusion process of solvent, both can leach the effective ingredient in the medical material, avoid again simultaneously because of the influence of the heating process in producing to effective ingredient.Medicines such as Borneolum Syntheticum, chloromycetin, salicylic acid directly add in the impregnation liquid, thus guaranteed each composition in process of production chemical stability and in technology unnecessary loss.
The specific embodiment:
Tincture in the present embodiment mainly is to be made by following bulk drugs: Radix Angelicae Dahuricae 10-30 part, Margarita powder 10-50 part, Semen Armeniacae Amarum 10-30 part, Semen Ginkgo core 10-80 part, Bulbus Fritillariae Cirrhosae 10-30 part, Borneolum Syntheticum 10-30 part, chloromycetin 5-30 part, salicylic acid 5-30 part.
Be preferably: 15 parts of the Radixs Angelicae Dahuricae, 20 parts of Margarita powder, 10 parts of Semen Armeniacae Amarums, 70 parts of Semen Ginkgo core, 10 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Borneolum Syntheticums, 20 parts in chloromycetin, 20 parts of salicylic acid.
Concrete preparation method:
A, get Radix Angelicae Dahuricae 15g, Semen Ginkgo core 70g, Semen Armeniacae Amarum 10g and Bulbus Fritillariae Cirrhosae 10g and be ground into coarse powder, with Margarita powder 20g mixing, be equipped with in the lid container, add 75% ethanol 900ml, make medicine obtain enough infiltrations, airtight immersion 7 days is stirred 2 every day, filters;
Add Borneolum Syntheticum 10g, chloromycetin 20g, salicylic acid 20g in b, the filtrate, stir and make it dissolving;
C, regulate the scope of pH value at 3.0-5.0 with diluted acid or diluted alkaline;
D, the ethanol with 75% are adjusted total amount to 1000ml, make it contain the alcohol amount at 65-75%.
E, stir evenly, leave standstill, filtration, fill, check, packing promptly.
In order to obtain better therapeutic effect, in its side, can also add dexamethasone 100-300mg.The dexamethasone class is the potent corticosteroids medicine of synthetic, has powerful antiinflammatory, antitoxin, anti-allergic effects, and side effect such as water-sodium retention and row's potassium are slight, so clinical practice is wider.Can be used for each stage of various types of inflammatory reactions and inflammation at department of dermatologry, be widely used in treating various dermatopathies.Adding this product among the we has the therapeutical effect of rapid mitigation symptoms to the inflammatory reaction of all kinds of acne, can play potent and quick-acting synergisms.
This product is through Anhui Chinese Medicine College Affiliated Hospital, Anhui Province Affiliated Hospital of medical university and Attached Hospital of Bengbu Medical College's clinical practice, and carries out controlled observation with " Benzoyl Peroxide cream ", and clinical effectiveness is as follows:
One, physical data:
180 example checking patients are the outpatient service patients with acne, and wherein 110 examples are organized in checking, matched group 70 examples.
Checking is organized in 110 examples:
Male's 56 examples, women's 54 examples;
Minimum 14 years old of age, maximum 40 years old, average out to 22.56;
The course of disease was 24 examples less than 1 year, 43 examples of 1-3, greater than 3 years be 43 examples;
Clinical grading I degree 23 examples, II degree 72 examples, III degree 14 examples, IV degree 1 example.
In matched group 70 examples:
Male's 33 examples, women's 37 examples;
Minimum 14 years old of age, maximum 40 years old, average out to 23.67;
The course of disease was less than 22 examples in 1 year, and 37 examples of 1-3 were greater than 11 examples in 3 years;
Clinical grading I degree 18 examples, II degree 42 examples, III degree 9 examples, IV degree 1 example.
Treatment group and matched group at sex, age, the course of disease and Clinical typing, learn to handle P＞0.05 by statistics and have comparability.
Two, case selection,
1, diagnostic criteria:
I degree (slightly), blackhead is distributed to multiple struvite erythra, distributes.
II degree (medium degree), I degree+shallow at the property pustule, the struvite erythra a few days increases, and is confined to face.
III degree (severe), II degree+, betide face, cervical region, chest and back deeply in the struvite erythra of property.
IV degree (severe-collection bunch property), III degree+cyst easily forms cicatrix, betides above the waist.
2, MethodsThe cases enrolled standard:
All selected cases all meet above diagnostic criteria.
3, get rid of the case standard:
The person that do not meet the inclusion criteria, or the acne sample skin that some drugs causes is examined;
Merge to have the inclination, liver, renal function injury person, the psychotic;
Test in the last week or in the process of the test and take or be coated with similar medicine person outward;
Not medication in accordance with regulations can't judge that curative effect or data are not congruent, affects the treatment or safety judgement person.
Three, Therapeutic Method:
By 1: 1 pair principle, each 70 example of checking group and matched group, the checking group enlarges 40 examples, totally 180 examples.
Checking group: use this product.
Matched group: use the Benzoyl Peroxide cream
The course of treatment: both equal continuous uses 15 days were a course of treatment, and meter is observed 2 courses of treatment.
Four, curative effect judging standard:
1, recovery from illness: inflammation disappears, wound healing, and deflorescence leaves temporary pigmentation spots.
2, produce effects: inflammation disappears, wound healing is more than 70%, deflorescence 70% or more or rising twice.
3, effective: inflammation disappears more than 30%, and deflorescence is more than 30%, and pain, pruritus alleviate or once rise.
4, invalid: erythra changes not obvious or increases the weight of.
Five, therapeutic outcome:
1, clinical efficacy
Table 1 checking group and matched group Comparison of therapeutic
| Sum | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate | Obvious effective rate | |
| The checking group | 110 | ?88(80％) | 15 ??(13.64％) | 5(4.54％) | 2(1.82％) | 98.18％ | 93.64％ |
| Matched group | 70 | ?24 (34.29％) | 22(31.43％) | 19(27.14) | 5(4.55％) | 92.86％ | 65.71％ |
| X 2 | ??????????????????????????????????????????????????????????????????3.84??????????23.39 | ||||||
| P | ??????????????????????????????????????????????????????????????????＞0.05????????＜0.001 | ||||||
As seen from the above table, the clinical total effective rate of this product is 98.18%, and matched group is 92.86%.Both statistical procedures P＞0.05; Total obvious effective rate of checking group is 93.64%, and matched group is 65.71%, X
2=3.39, P＜0.001; Significant differences is arranged.
Model case: what certain, the man, 22 years old, pimple appearred in Yin E, face, acne were gone to a doctor in 2 years.The patient began pimple and acne to occur prior to forehead before 2 years, and developed into buccal cumulative more, the pustule that often occurs together, and increase the weight of spring and summer, repeatedly outbreak.Once repeatedly be coated with medicines such as Gooch lotion, oral metronidazole outward,, can not disappear though skin lesion can alleviate.More pimple also gradually appears in shoulder, back since more than nearly half a year, and has prodding and itching feeling to feel when perspiring.
Health check-up: grow normally, systems inspection is no abnormal, forehead, buccal and shoulder, back to weighing up the red pimple of now more syringe needle to the Sorghum vulgare Pers. size, the erythra of buccal portion has a bunch collection tendency, during extruding, as seen the part papular top has blackhead, and body is filemot fat bolt.The visible pustule of part papular top flows out heavy-gravity pus behind the ulceration.Left side jaw portion still has the big kermesinus cyst sample of an about Semen arachidis hypogaeae to damage, and quality is medium and light tenderness arranged.The erythra bunch Ji Chu of buccal portion is with filbert pigmentation.
Lab testing: before the treatment and the blood more, routine urinalysis all in normal range.
Diagnosis: III degree (severe) acne vulgaris.
Treatment: use earlier the warm water cleaning affected part, do afterwards and to dip in this product with hairbrush and directly be coated with and put skin lesion on the skin, every day 4 times.Treatment 1 week back deflorescence 30% is treated 2 all erythra and is disappeared approximately more than 70%, continues treatment, 3 week the back erythra just all disappear.Control other any medicine of forbidding in the journey.The coating place other side effect do not occur except that burn feeling and a small amount of desquamation are arranged.Follow up a case by regular visits to after the recovery from illness and do not see the erythra recurrence in 1 month.
Claims (4)
1, a kind of tincture for the treatment of acne, it is characterized in that it mainly is to be made by following bulk drugs: Radix Angelicae Dahuricae 10-30 part, Margarita powder 10-50 part, Semen Armeniacae Amarum 10-30 part, Semen Ginkgo core 10-80 part, Bulbus Fritillariae Cirrhosae 10-30 part, Borneolum Syntheticum 10-30 part, chloromycetin 5-30 part, salicylic acid 5-30 part.
2, the tincture of treatment acne according to claim 1 is characterized in that described each crude drug consumption is 15 parts of the Radixs Angelicae Dahuricae, 20 parts of Margarita powder, 10 parts of Semen Armeniacae Amarums, 70 parts of Semen Ginkgo core, 10 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Borneolum Syntheticums, 20 parts in chloromycetin, 20 parts of salicylic acid.
3, the preparation method of the tincture of a kind of claim 1 or 2 described treatment acne, its feature has following steps:
A, get the Radix Angelicae Dahuricae, Semen Ginkgo core, Semen Armeniacae Amarum and Bulbus Fritillariae Cirrhosae powder and be broken into coarse powder, with the Margarita powder mixing, be equipped with in the lid container, add the ethanol of 50-80%, alcoholic acid addition was to cover medicine, enough to soak into degree of being, airtight immersion 7 days is stirred 2 every day, filtration;
Add Borneolum Syntheticum, chloromycetin, salicylic acid in b, the filtrate, stir and make it dissolving;
C, adjusting pH value are 3.0-5.0;
The ethanol adjustment of d, usefulness 50-80% makes it contain the alcohol amount and is 65%-75%;
E, stir evenly, leave standstill, filtration, fill, check, packing promptly.
4, the tincture of treatment acne according to claim 1 is characterized in that crude drug wherein also has: dexamethasone 0.01-0.03 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031133002A CN1238032C (en) | 2003-04-25 | 2003-04-25 | Tincture for curing acne and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031133002A CN1238032C (en) | 2003-04-25 | 2003-04-25 | Tincture for curing acne and preparation method |
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| Publication Number | Publication Date |
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| CN1539433A true CN1539433A (en) | 2004-10-27 |
| CN1238032C CN1238032C (en) | 2006-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB031133002A Expired - Fee Related CN1238032C (en) | 2003-04-25 | 2003-04-25 | Tincture for curing acne and preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077971A3 (en) * | 2008-12-17 | 2010-11-04 | Harmony Laboratories, Inc. | Acne treatment powder foundation |
| CN101574465B (en) * | 2009-05-25 | 2012-05-02 | 安徽省泽平制药有限公司 | Special acne removal traditional Chinese medicine tincture for ladies |
| CN102949564A (en) * | 2011-08-25 | 2013-03-06 | 贵州特色制药有限责任公司 | Preparation method of Yinbing acne-elimination tincture |
| CN103961296A (en) * | 2014-04-30 | 2014-08-06 | 王海云 | Skin-care product for treating acne and preparation method thereof |
| CN105031190A (en) * | 2015-07-03 | 2015-11-11 | 赵德欣 | Beauty-maintaining and spot-removing traditional Chinese medicine composition and preparation method thereof |
-
2003
- 2003-04-25 CN CNB031133002A patent/CN1238032C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010077971A3 (en) * | 2008-12-17 | 2010-11-04 | Harmony Laboratories, Inc. | Acne treatment powder foundation |
| US9125919B2 (en) | 2008-12-17 | 2015-09-08 | Ei Llc | Acne treatment powder foundation |
| CN101574465B (en) * | 2009-05-25 | 2012-05-02 | 安徽省泽平制药有限公司 | Special acne removal traditional Chinese medicine tincture for ladies |
| CN102949564A (en) * | 2011-08-25 | 2013-03-06 | 贵州特色制药有限责任公司 | Preparation method of Yinbing acne-elimination tincture |
| CN103961296A (en) * | 2014-04-30 | 2014-08-06 | 王海云 | Skin-care product for treating acne and preparation method thereof |
| CN105031190A (en) * | 2015-07-03 | 2015-11-11 | 赵德欣 | Beauty-maintaining and spot-removing traditional Chinese medicine composition and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1238032C (en) | 2006-01-25 |
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