CN1535605A - Drink and food - Google Patents
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- CN1535605A CN1535605A CNA2004100337257A CN200410033725A CN1535605A CN 1535605 A CN1535605 A CN 1535605A CN A2004100337257 A CNA2004100337257 A CN A2004100337257A CN 200410033725 A CN200410033725 A CN 200410033725A CN 1535605 A CN1535605 A CN 1535605A
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Abstract
Provided is food and drink useful for promoting fat combustion, enhancing basal metabolism and improving obesity, when ingested. The food and drink contain hydroxycitric acid or its salt, and carnitine or its salt, and/or a precursor thereof. The precursor of the cartinine contained in the food and drink comprises any one of lysine or its salt and methionine, or both of the lysine or its salt and the methionine. The food and drink further contain coenzyme Q10. Thus, the food and drink are useful for promoting the fat combustion, and/or enhancing the basal metabolism and/or improving the obesity.
Description
Technical field
The present invention relates to a kind of picked-up that is beneficial to, for promoting fat combustion, accelerate the energy metabolism and improving the diet product that obesity etc. has remarkable result.
Technical background
Since in recent years obesity and the overweight main diseases that not only becomes various diseases such as diabetes because of, and the trend that increases is gradually arranged, also be well known for society and burden and loss that economic aspect caused.But must change existing life style significantly because keep on a diet, therefore its where the shoe pinches is arranged, have the appearance of food of effect such as hoard, enhance metabolism of substituting low-calorie, blocking-up fat absorption, appetite-suppressing, prevention fat and just expected by society.Though the medicament that possesses above function is arranged in the medicine, to open the relation that ability is used because be only limited to the doctor, and be not easy to obtain, these medicaments are still in food hygiene law now and forbid in the daily food that eats.
In view of above-mentioned present situation, the appearance that can substitute these medicaments and more handy food is expected by popular.At present on the market as suppress the absorption that the gymnemic acid fir card (Gymnemasylvestre) that sugar absorbs and this two kinds the composition of chitosan (chitosan) that hinders fat absorption all only are saccharide and lipid when suppressing feed, be deposited in intravital fat and can not reduce.But losing weight most important is to remove the fat of building up in the body.
Be deposited in body fat with regard to reducing, can enumerate and suppress lipogenesis, decompose the method for piling up fat, promoting the metabolism or the like of the fatty acid that goes out by steatolysis.
Just suppress the raw material of lipogenesis, that well known is Fructus Resina garciniae (Garciniacambogia), calls to be tamarind pearl fruit (malabar tamarind).Contain the acid of hydroxyl lemon lemon in the Fructus Resina garciniae (Garciniacambogia).The acid of hydroxyl lemon lemon is that organic acid is a kind of, and its composition is that the hydrogen in the hydroxyl lemon lemon acid (hydroxycitric acid) is replaced into hydroxyl.The acid of hydroxyl lemon lemon can stop by citric acid in the organism and disengage that the branch enzyme is split in the adenosine triphosphate (ATP) and the acid of lemon lemon that synthesize in the fatty process enzyme.The increase that suppresses body fat mass is well known for treating fat the most powerful.(J.Biol.Chem.，Vol.245，No.22，p.5993-6002，1970)。Moreover, decompose the fat of accumulating in fatty tissue, must be by stimulating sympathetic nerve, promote norepinephrine (noradrenaline) and epinephrine (adrenaline) secretion, stimulating fatty tissue thus.Adrianol is a composition contained in the citrus, and the original adipose cell of the mammals of stimulation is arranged, and promotes fat-splitting effect.(No. 5, C Racad Sci III 316 volumes, 519-523 page or leaf, 1993)
Moreover, by the fatty acid that steatolysis goes out, see through mitochondrial membrane again via after the oxidation, can be used as energy and use it.Carnitine is called 4-trimethylamine-3-hydroxyl butyric acid or 4-trimethylamine-hydroxyl butyrobetaine (hydroxybutyrobetaine) again, all contains this carnitine in nearly all organism, also is fatty acid indispensable composition will be by mitochondrial inner membrance the time.When this carnitine is that fatty acid uses as energy, play the part of very important role.Moreover the methyl in the carnitine is made of methionine, and its carbon element is made of lysine, and this two seed amino acid has the function that replaces carnitine.When using the aminoacid of presoma to substitute carnitine, for the activity of the synzyme of keeping carnitine, vitamin C and iron ion or the like also are one of indispensable elements.(pediatric surgery, vol.19 no.8, p.1023-1029,1987-8)
The coenzyme Q10 another name is mended enzyme Q1
0 reachesVitamin Q, or be called ubiquinone ubiquinone (ubiquinone) or ubidecarenone (ubidecarenone), meat in the food and eggs contain several μ g/g, then are a synthetic nutrient in organism.Its significant feature is antioxidation, promotes energy to produce, improve respiro circulatory function, promotes immunity and pre-anti-aging or the like.Important component in the electronics that coenzyme Q10 is produced in the energy oxidizing process is especially passed on has that to accelerate the function that saccharide or lipid homenergic source produce also be well known.Moreover, each about 0.01～500mg that is grown up of the intake of coenzyme Q10.
Summary of the invention
Obesity is one of unhealthful reason.As mentioned above, reach the effect of fat-reducing most important be exactly reduce intravital fat.In order to reduce the fat of body accumulation, promoting fat combustion and promoting the energy metabolism all is effective methods.Therefore, the food of safety and picked-up easily extensively is popular required.But the diet product that have this complete function are not still gone public.Purpose of the present invention promptly is to assemble above viewpoint, and providing a kind of has remarkable result for promotion fat combustion, lifting basal metabolism especially, and the diet product that absorb easily.
The present invention with research and develop a kind of by the lemon acid of hydroxyl lemon or its esters, carnitine (carnitine) or its esters with and/or the diet product that constituted of the lysine (lysine) of its presoma or its esters and methionine (methionine).By absorbing this diet product, can not only suppress lipogenesis, decompose and to accumulate fat and to promote metabolism by the fatty acid that fat decomposited, and, reach purpose of the present invention especially at promoting fat combustion and promoting the effect that highly significant is arranged on the energy metabolism.Moreover, add vitamin C, Vitamin B6, nicotinic acid (nicain), irony, adrianol (synephrine), Rhizoma Zingiberis Recens and/or Fructus Capsici again and contain above-mentioned diet product, be to strengthen its effect.Contain in the diet product of the lysine of lemon acid of hydroxyl lemon or its esters and carnitine (carnitine) or its esters and/or its presoma or its esters and methionine, after adding contains coenzyme Q10, Vitamin B1, Rhizoma Zingiberis Recens and Fructus Capsici again, can obviously reduce body weight and effectively improve fat remarkable excellent effect.
Diet product of the present invention are characterised in that and contain the lemon acid of hydroxyl lemon or its esters and carnitine or its esters and/or its presoma.
Above-mentioned diet product are characterised in that the presoma that contains carnitine is the one or both with lysine or its esters and methionine.
Above-mentioned diet product are characterised in that and contain coenzyme Q10.
Above-mentioned diet product are characterised in that and contain vitamin C, Vitamin B6, nicotinic acid (nicain), irony, adrianol, Rhizoma Zingiberis Recens and Fructus Capsici.
Above-mentioned diet product are characterised in that and contain Vitamin B1, Rhizoma Zingiberis Recens and Fructus Capsici.
Above-mentioned diet product are characterised in that to have functions such as can promoting fat combustion and/or quickening energy metabolism.
By the present invention, provide a kind of with research and development and can effectively promote fat combustion and promote the metabolic diet product of energy.
Description of drawings
Fig. 1 is the metabolic measurement result of demonstration energy of expression diet product of the present invention;
Fig. 2 is the measurement result of the body weight change amount of expression diet product of the present invention;
Fig. 3 is the measurement result of the BMI variable quantity of expression diet product of the present invention.
The specific embodiment
The present invention with in the diet product, add hydroxyl lemon lemon acid or its esters (hereinafter to be referred as HCA), carnitine or its esters with and/or compositions such as the lysine of its presoma and methionine after, can mix and can promote fat combustion and have the diet product that promote energy metabolism function.But when the presoma that lysine and salt thereof and methionine are used as carnitine was used, adding vitamin C, Vitamin B6, nicotinic acid, irony etc. again was its ideal.
HCA and its esters content in the diet product is about among every 100g and contains 10～45000mg, ideal amount is 500～30000mg, carnitine and its esters 1～45000mg, and with the amount of lysine and its esters and methionine, lysine hydrochloride is 1～40000mg, and it is ideal that methionine also is all the allotment amount of 1～40000mg.By drinking diet product of the present invention, can effectively promote fat combustion, and reach the basic metabolic purpose of lifting.
Moreover the content of coenzyme Q10 in the diet product is about among every 100g and contains 0.01～15000mg, and is ideal with the amount cooperation of 0.01～2000mg.Contain metabolism that this coenzyme Q10 can activation evergy in the diet product, promote energy source fat combustion, and can effectively promote basal metabolism.
The person of connecing can stimulate adipose cell by adding again, after the essence of the adrianol of the acid that reduces fat and Rhizoma Zingiberis Recens and Fructus Capsici, more can promote steatolysis.Compared with above-mentioned by the lemon acid of hydroxyl lemon or its esters, carnitine or its esters with/and or the metabolism amount of its presoma institute activation, have its more significant effect.
Moreover Vitamin B1 is by its energy of activation metabolic TCA loop and the power conversion that promotes saccharide, can the metabolism of activation energy, advance fat combustion more effective time.
Hydroxyl lemon lemon acid used in the present invention and its esters are one of them salt of hydroxyl lemon lemon acid or its lactone type (lactone) or this.This salt has sodium salt, potassium salt or the like alkaline metal salt for instance, also has magnesium salt, calcium salt or the like kind.Here acid of hydroxyl lemon lemon and its esters can be by obtaining in the synthetics or in the natural goods that is extracted in the fruit.With natural goods, be distributed in the fruit of the Resina garciniae class (Garcinia) of torrid areas, contain many especially this kind elements in its peel.For example Fructus Resina garciniae (Garcinia cambogia), India's Carcinia mangostana L. (Garciniaindica), Garcinia atroviridis or the like.Obtain the method for lemon acid of hydroxyl lemon and its esters, can peel drying with these plants after, utilize pulverizer to obtain; Or utilize ethanol, water or hot water that its fruit is extracted essence, and adding dextrin, the method for making of utilizing spray drying to make it powdered again obtains; In addition, also have other method to obtain according to this method for making.
Carnitine and its esters are the things via gained after chemosynthesis and the optical segmentation, or are the thing that utilizes microbial fermentation later its sophistication to be extracted.For example the ethanol that takes out in composite such as L-carnitine, DL-carnitine, carnitine hydrochloride, L-carnitine L-tartrate, L-carnitine fumaric acid, L-carnitine magnesium citrate, acetyl group L (acettk L)-carnitine hydrochloride or beef by being rich in carnitine and the Carnis caprae seu ovis, by the essence of taking-ups such as water or hot water, add dextrin, the method for making of utilizing spray drying to make it powdered again obtains; In addition, also have other method to obtain according to this method for making.
In addition, the also lysine of available amino acid and its esters, and methionine is used as the presoma of carnitine.Lysine is a kind of of essential amino acids, is the aminoacid of being found by in the milk in early days, is rich in fish and shellfish, meat and liver class or the like.Point out that according to report it can promote glucose metabolism and in-vivo tissue and calcium absorption that very confidential relation is arranged in intravital acting as.And methionine also is a kind of of essential amino acids, is otherwise known as to contain the sulfur-containing amino acid of sulfur, all is rich in methionine in milk, liver and the whole wheat.Show that according to report methionine has the effect of the blood level that can reduce histamine in body, and helps the tissue regeneration of liver or kidney.
By with the acid of these hydroxyl lemon lemons and its esters, carnitine and its esters and or compositions such as the lysine of its presoma and methionine, add coenzyme Q10 together to absorb, can more effective promotion fat combustion, the metabolic purpose of lifting energy.
Coenzyme Q10 another name is mended enzyme Q10 and vitamin Q, or is called ubiquinone ubiquinone or ubidecarenone (ubidecarenone), and meat in the food and eggs contain several μ g/g, then is a synthetic nutrient in vivo.Its significant feature is antioxidation, promotes energy to produce, improve respiro circulatory function, promotes immunity and pre-anti-aging or the like.Employed raw material is, by the pure material that takes out in the natural goods, maybe a part of benzoquinone that will extract thing and synthetic isoprene polymerization later later material or utilize microorganism etc. to make it to ferment, again the material that takes out via essence, also or in order to make it easier processing, make it material of emulsifying or powdered gained or the like, all can bring use.
In addition, by with the acid of these hydroxyl lemon lemons and its esters, carnitine and its esters and or compositions such as the lysine of its presoma and methionine, add vitamin C, Vitamin B6, nicotinic acid, irony, adrianol, Rhizoma Zingiberis Recens with and/or together picked-up such as Fructus Capsici, can reach effective promotion fat combustion, and promote the metabolic purpose of energy.
Vitamin C is the water solublity vitamin, and another name is called ascorbic acid again.Be rich in fresh fruit, vegetable and green tea etc.In the body as be rich in vitamin C, can not only antioxidation, more help the absorption of the synthetic and irony of collagen.It uses raw material to be, oxidized form after the chemosynthesis or reduced form vitamin C, sodium ascorbate, all can bring use for the ascorbic acid 2-glucoside (glucoside) of inductor and by the material of essence such as plant, fruit taking-up etc.
Vitamin B6 is the water solublity vitamin also, is rich in animal, yeast, beans to reach the Grains apoplexy due to endogenous wind.Vitamin B6 be pyridoxol, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine., pyridoxamine and above these materials again with the general name of six kinds of materials of phosphoric acid be combined into.Its function is for using as the benefit enzyme of many enzymes such as the transiminase of amino acid metabolism and decarboxylase.The raw material of its use is, chemosynthesis later Vitamin B6 or be that pyridoxine hydrochloride etc. all can be used.
Nicotinic acid is water solublity vitamin B group, and its chemical name is also referred to as nicotinic acid.By finding in Testa oryzae and the yeast, be that a Buddhist nun restrains aminoacid in animals and plants.Benefit enzyme as energy-producing enzyme uses, with other vitamin B faciation with, essential vitamin group when being saccharide, fat etc. and desiring to change into energy.It uses raw material to be, restrains aminoacid etc. via the nicotinic acid of chemosynthesis or Buddhist nun and all can use.
Irony is one of metallic element, one of micronutrient that all contains for all plants.In plant, major part is a complex compound; Then be the hemoglobin element in the vertebrates erythrocyte in animal body.It uses raw material to be, the yeast of heme iron (heme iron) that animal blood is handled by enzyme and ferrous citrate (ferrous citrate), ferric phrophosphate (ferricpyrophospate), ferric lactate, reinforcement irony, can be used by the pure material that takes out such as plant, Sargassum etc.
Adrianol (synephrine) is a salt-base substances, has the molecular configuration of C8H18NO2.Originally be a kind of of Chinese medicine, specially control dyspepsia, constipation, myocardial infarction, anti-inflammatory or the like symptom.It act as and can promote adrenaline secretion, stimulates the adipose cell acid or the like that reduces fat.No matter being synthetic or natural goods etc., adrianol all can use it.With natural goods for instance, contain many this kind compositions in the citrus, for example Citrus aurantium Linn. (CitrusAurantium L.), citrus reticulata, orange, Fructus Citri Limoniae, flat Fructus Citri tangerinae (Citrus deprssa Hayata), Fructus Citri grandis, Fructus Citri Sarcodactylis, Yi Yuju (Citrus iyo Hort.exort.ex Tanka), must field Fructus Citri tangerinae (Citrussudachi Hort.ex Shiral), Datang Citrus chachiensis Hort. (Citrus sphaerocarpa Hort.ex Tanaka), summer Citrus chachiensis Hort. etc.These fruits ripe or immaturity plant still, peel, seed, leaf, leaf stalk, branch, root and flower etc. are squeezed the juice later or after the drying, are utilized pulverizer to obtain; Or utilize ethanol, water or hot water extraction to go out essence, and adding dextrin, the method for making of utilizing spray drying to make it powdered again obtains; In addition, also have other method to obtain according to this method for making.
Rhizoma Zingiberis Recens is a Zingiberaceae class plant, and formal name used at school Zingiber Officinale is taken as stimulation cycle since ancient times on Europe and China and other places and the medicine that is good for the stomach uses.Contain many compositions in the Rhizoma Zingiberis Recens, wherein more famous have zingiberol (gingerol), shogaol (shogaol) and (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone (zingerone) or the like.(4-hydroxy-3-methoxyphenyl)ethyl methyl ketone is one of pungency component, generally acknowledges effects such as the hormone of stimulation susceptibility lipase, promotion steatolysis are arranged in adipose cell.It uses raw material is after the Cortex Zingiberis drying, to utilize pulverizer to obtain; Or utilize ethanol, water or hot water also or with super critical point to extract essence, and adding dextrin, the method for making of utilizing spray drying to make it powdered again obtains; In addition, also have other method to obtain according to this method for making.But use and comprise the raw material of (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone for the most desirable.
Fructus Capsici is a plant of Solanaceae, formal name used at school Capsicum annuum L. or Capsicumfrutescens.In DIYU daily life such as Central and South America and Asia, extensively absorbed.The acid of Fructus Capsici is strong, and it comprises composition is capsaicin.After capsaicin absorbs in vivo, the nervus centralis in brain and the spinal cord be can stimulate, epinephrine and norepinephrine secreted.These hormone can stimulate adipose cell, promote steatolysis.The raw material of its use is after the epidermis drying with Fructus Capsici, to utilize pulverizer to obtain; Or utilize ethanol, water or hot water extraction to go out essence, and adding dextrin, the method for making of utilizing spray drying to make it powdered again obtains; In addition, also have other method to obtain according to this method for making.The usage ratio of the capsaicin material of above gained is evaluated according to the amount of measuring capsaicin in the material.The amount of capsaicin is 0.01～1500mg in the 100g diet product, and the capsaicin that absorbs 0.02～1000mg is ideal.There are not much effects as the amount that comprises the following capsaicin of 0.01mg for the promotion steatolysis among the diet product 100g; And its zest of words that comprises more than the 1500mg is too strong.
Vitamin B1 another name thiamine, thiamine or aneurine.For preventing beriberic water solublity vitamin.Be rich in meat, frumentum and beans, with the conduction of neural aspect substantial connection arranged, in addition as the metabolic benefit enzyme of energy, promotion saccharide etc. is converted to energy source.The raw material of its use is, later thiamine salt hydrochlorate of chemosynthesis, thiamine nitrate and the essence that extracts as the octane thiamine of inductor, the thiamine of muttering (fursultiamine), benfotiamine (benfotiamine), two benzene vinegar thiamine (bisbentiamine) and by natural goods etc. etc. all can be used.
Vitamin B6 is the water solublity vitamin also, is rich in animal, yeast, beans to reach the Grains apoplexy due to endogenous wind.Vitamin B6 be pyridoxol, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine., pyridoxamine and above these materials again with the general name of the kind material of phosphoric acid be combined into.Its function is for using as the enzyme of many enzymes such as the imino group enzyme of amino acid metabolism and decarboxylase.The material of its use is, later he of chemosynthesis orders B6 or is that pyridoxine hydrochloride etc. all can be used.
Though the structure of above these element chemistry effects can't judge accurately that we can be presumed as follows in detail.Fat is fat main cause, and it is that an adipose cell is hoarded in body.Want to reduce body fat, most important is to reduce fat to make it to be converted to energy and consume.In order to reduce fat, must allow interior the dripping of lipase and adipose cell contact, therefore getting profit stimulates adipose cell with hormone such as norepinephrine and epinephrines.Adrianol can show adrenergic usefulness, decomposites fatty acid by direct stimulation adipose cell; The essence of adding Fructus Capsici, Rhizoma Zingiberis Recens stimulates sympathetic nerve, by promoting epinephrine and secreting of norepinephrine adipose cell is decomposed into fatty acid.Just be converted back to citric acid via the fat acid that decomposites after the carnitine effect again.In order be permanently effective fatty acid change back citric acid, except the interpolation carnitine, more should replenish the propylhomoserin of carnitine raw material and methionine at any time.In addition, can synthesize carnitine in order to make this two seed amino acid, must add compositions such as vitamin C, Vitamin B6, nicotinic acid and irony again, supplying these compositions simultaneously is very important rings.Can transfer energy source to though change back the fat acid of citric acid, but need utilize the acid of hydroxyl lemon lemon to prevent that those are not converted to energy source, synthesize the generation of saccharide fat thing once again, promote body fat acid to be converted to energy source.
Moreover, by the lemon acid of hydroxyl lemon or its esters, carnitine or its esters with and/or the propylhomoserin of its presoma and methionine add coenzyme Q10, Vitamin B1, Rhizoma Zingiberis Recens and Fructus Capsici etc. and together absorb, the independent separately picked-up of ratio more can reach the effect that promotes fat combustion, and can promote energy metabolism.By Rhizoma Zingiberis Recens and Fructus Capsici, stimulate sympathetic nerve earlier, make it to secrete hormone such as epinephrine and norepinephrine.These hormone can stimulate the body fat cell, and neutral fat is decomposed into fatty acid.Decompose fat acid later and be transported in intravital muscle and the liver again, be carnitine with this neccessary composition that is converted to energy source this moment, and carnitine is for allowing fatty acid pass to have the neccessary composition of the mitochondrial inner membrane of energy metabolic function.After passing the fatty acid beta-oxidation of inner membrance, the reception and registration via TCA loop and electronics comes metabolisable energy again.At this moment, coenzyme Q10 in electronics is passed on, play the part of mend enzyme role effect it, in addition, Vitamin B1 has promoted the activation in TCA loop and saccharide TCA loop, promotes energy metabolism more.Moreover, the acid of hydroxyl lemon lemon can effectively suppress to be called the enzyme of ATP citrate-lyase (lyase), preventing that those remaining citric acids that are not converted to energy source from can go back to once again is further to promote the efficient that the fatty acid that decomposites in the body is converted to energy source by fat.By thus and thus reducing fat swimmingly and the switching energy source, the metabolism of the lifting energy that can accelerate further improves fat.
By the power conversion of body fat smoothly like this, can promote fat combustion and further upwards promote the energy metabolism.
Diet product form of the present invention is not particularly limited.Comparatively desirable as the form that beverage, granule, lozenge, capsule and snack categories etc. are edible easily.In addition, the form of food of the present invention comprises in all medical treatment and the field of food, all forms that the utilization general technology just can create.When making with the form of Medicines, the raw material that uses of its preparation is starch, cellulose, dextrin, calcined dolomite in powder, calcium carbonate and dietary fiber or the like excipient; Sucrose fatty acid ester, vegetable oil powder, hard ester acid (stearic acid) magnesium or the like lubricant; Acacia gum, guar gum (Cyamoposis gum), xanthan gum bonding agent such as (xanthan gum); Tranquilizer such as soybean polysaccharides and pectin; And flavoring agent, additive or the like such as saccharide, sugared ether, sweet taste material, organic acid, fruit juice, in common food and pharmaceuticals, all can be used as adding ingredient and use it.
According to the present invention institute institute diet product of research and develop act one example, for example with hydroxyl lemon lemon sour and its esters, carnitine and its esters and or the lysine of its presoma and methionine add vitamin C, Vitamin B6, nicotinic acid, irony, adrianol, Rhizoma Zingiberis Recens and or Fructus Capsici, saccharide, sweet taste material, acid flavoring, fruit juice and spice etc. be dissolved in the water.In addition, it is good to be added into vitamin, minerals etc. again, these raw materials is mixed just can.Pile after the mixing in container, optionally sterilization just can be finished this product later again.Above manufacture method there is no special qualification.
In addition, equally with the acid of hydroxyl lemon lemon and its esters, carnitine and its esters and or the lysine of its presoma and methionine add coenzyme Q10, Vitamin B1, Rhizoma Zingiberis Recens and or Fructus Capsici, excipient and mix lubricant after, utilize water or ether to make it to become graininess, just can finish this product via piling to hard capsule after dry and the one-tenth graininess.Above prilling process and drying means are not particularly limited.
About the usage ratio of each composition of food of the present invention, as according to aforesaid hydroxyl lemon lemon acid or its esters, carnitine or its esters with and/or the usage ratio of its presoma, there is no special qualification.For instance, can wish that this product contains the lemon acid of hydroxyl lemon or its esters of 1 weight portion, the carnitine of 0.005～10 weight portion or its esters with and/or its presoma (for example lysine or its esters or methionine), the vitamin C of 0.005～5 weight portion, the Vitamin B6 of 0.00005～0.1 weight portion, the nicotinic acid of 0.0005～0.1 weight portion, the irony of 0.00005～0.1 weight portion, the adrianol of 0.00005～0.2 weight portion and the Rhizoma Zingiberis Recens or the Fructus Capsici of 0.001～0.5 weight portion.
Or, this product contain the carnitine of the hydroxyl lemon lemon acid of 1 weight portion or its esters, 0.005～10 weight portion or its esters with and/or its presoma (for example lysine or its esters or methionine), the coenzyme Q10 of 0.0001～1 weight portion, the Vitamin B1 of 0.0001～0.5 weight portion, the Rhizoma Zingiberis Recens of 0.001～0.5 weight portion and the Fructus Capsici of 0.001～0.5 weight portion.
Below, by embodiment and experimental example the present invention is described, but the present invention is not limited to this.
Embodiment 1
According to the raw material that table 1 listed, make the diet product of Beverage Service thing 1,2,3 and comparative example 1 and 2 with following method.At first all raw materials are added water and mix, dissolve, make it again to be filled in the container, with 85 ℃ of sterilizations of high temperature 10 minutes.Treat that this diet product have just been finished after the sterilization cooling.The Beverage Service thing 1,2,3 of one jar (50ml) and the diet product heat of comparative example 1 and 2 are 16kacl.
Table 1
| Use raw material | Cooperate example 1 | Cooperate example 2 | Cooperate example 3 | Comparative example 1 | Comparative example 2 |
| The acid of hydroxyl lemon lemon | ??1010mg | ??1000mg | ??1200mg | ??1010mg | ??0mg |
| Adrianol | ??1mg | ??1mg | ??1mg | ??1mg | ??1mg |
| Carnitine | ??15mg | ??0mg | ??10mg | ??0mg | ??10mg |
| Irony | ??4mg | ??4mg | ??4mg | ??4mg | ??4mg |
| + Rhizoma Zingiberis Recens essence | ??10mg | ??10mg | ??10mg | ??10mg | ??10mg |
| Lysine hydrochloride | ??12.5mg | ??12.5mg | ??12.5mg | ??12.5mg | ??12.5mg |
| Methionine | ??10mg | ??10mg | ??10mg | ??10mg | ??10mg |
| The inferior acid of anti-ring | ??50mg | ??50mg | ??50mg | ??50mg | ??50mg |
| Vitamin B6 | ??0.5mg | ??0.5mg | ??0.5mg | ??0.5mg | ??0.5mg |
| Nicotinic acid | ??6mg | ??6mg | ??6mg | ??6mg | ??6mg |
| Citric acid | ??0.5g | ??0.5g | ??0.5g | ??0.5g | ??0.5g |
| Maltose alcohol | ??2.7g | ??2.7g | ??2.7g | ??2.7g | ??2.7g |
| Erithritol | ??2.7g | ??2.7g | ??2.7g | ??2.7g | ??2.7g |
| Trehalose | ??- | ??- | ??- | ??- | ??1.0g |
| Concentrate orange juice | ??0.9g | ??0.9g | ??0.9g | ??0.9g | ??0.9g |
| Fructus Momordicae is quenched and is got thing | ??16mg | ??16mg | ??16mg | ??16mg | ??16mg |
| Spice | ??0.13 | ??0.13 | ??0.13 | ??0.13 | ??0.13 |
| Water | Necessary amount | Necessary amount | Necessary amount | Necessary amount | Necessary amount |
| Full dose | ??50ml | ??50ml | ??50ml | ??50ml | ??50ml |
(test result)
Done following experiment with the diet product that the present invention was researched and developed.Adult female with health is a testee, specifies the dinner of its feed the previous day earlier in test.Again after test is got up at day morning on the same day, settle the quizzee in the control laboratory of a constant temperature and humidity degree 30 minutes, begin to measure the energy metabolism rate before drinking then.After mensuration before drinking was over, diet product and breakfast of these research and development of taking food were again measured once in then per 30 minutes, continued 2 hours, and minute once is 5 minutes.Be set at six days during metabolic.The metabolic mensuration of energy is that the gas of exhalation is adopted in inspection, calculates the energy metabolism amount that is equivalent to a day with this numerical value.
Fig. 1 indicates the metabolic measurement result of energy.The longitudinal axis is represented one day metabolic quantity of energy, transverse axis express time.0 is divided into the metabolism amount of drinking preceding energy, cooperates example 1～3 compared with comparative example 1 and 2 higher energy metabolism to be arranged.Can confirm that thus diet product of the present invention can promote the energy metabolism and quicken fat-splitting effect.
Embodiment 2
According to the raw material that table 2 listed, make the capsule medicament that cooperates example 4 and comparative example 3 and 4 with following method.At first all raw materials are added water and mix, make it to become granule, just can finish this capsule medicament via piling to hard capsule after dry and the one-tenth graininess again.
Table 2 (mg/ of unit percentage ratio)
| Composition | Cooperate example 4 | Comparative example 3 | Comparative example 4 |
| The acid of hydroxyl lemon lemon | ????69.75(41.85) | ????69.58(41.75) | ????0(0) |
| L-carnitine tartrate (carnitine) | ????25.13(16.7) | ????0 | ????0 |
| Coenzyme Q10 emulsifying powder (coenzyme Q10) | ????0.69(0.25) | ????0 | ????0 |
| Fructus Capsici (capsaicin) | ????3(0.015) | ????4.95(0.015) | ????0(0) |
| Vitamin B1 | ????0.11 | ????0 | ????0 |
| Citrus essence is got thing | ????0 | ????43.45 | ????0 |
| Chromium yeast | ????0 | ????4.13 | ????0 |
| Cellulose | ????89.32 | ????73.96 | ????272 |
| Dietary fiber | ????7.5 | ????5.5 | |
| Lactose | ????65.18 | ||
| Sucrose ester | ????4.5 | ????3 | |
| The vegetable oil powder | ????8.25 | ||
| Add up to | ????200 | ????275 | ????275 |
(test result)
Done following table 3 experiment with the capsule medicament that the present invention was researched and developed.With 18～59 years old age, the BMI value was that the adult men and women more than 23.5 is a testee.
[table 3]
| Cooperate example 4 | Comparative example 3 | Comparative example 4 | |
| Subject's number (man/woman) | ????3/2 | ????3/3 | ????1/3 |
| Age | ????38±2 | ????41±5 | ????33±7 |
| ????BMI | ????26.9±1.6 | ????27.2±2.7 | ????26.5±0,4 |
The method of test is a relatively test method of double-blind (Duoble Blind Test), will cooperate the test group of example 4 and comparative example 3 and 4 to be divided into 3 cohorts, allows eat after meal 4 of edible capsule medicaments of one day photograph 3 of each cohort.Mensuration begins to take preceding and takes the numerical value of body weight, height and BMI between 4 weeks afterwards then.So-called BMI is the abbreviation of Body Mass Index (BMI).With the numerical value of body weight, for concluding the foundation of obesity index divided by 2 times of gained of height (m).According to the investigation of Japanese health ministry, be standard to be difficult for most ill numerical value 22 on the statistics, high more its obesity index of numerical value is high more.What can be replenished in addition is, the determinating reference of the fat association of Japan is, BMI is in standard about in the of 22 10%; Also reach in 19.8～24.2 scopes to common, many 10% is higher than at 24.2 o'clock for fat slightly, 20% is higher than at 26.4 o'clock and then is called obesity more than again.
Fig. 2 is the body weight change amount, and Fig. 3 is the result of BMI variable quantity.The difference that body weight before the edible beginning and BMI cut after edible 4 weeks just is its variable quantity.Seeing through this experiment learns and contains lemon acid of hydroxyl lemon and carnitine, add the cooperation example 4 that contains coenzyme Q10, Vitamin B1 and do not comprise carnitine and the comparative example 3 of coenzyme Q10, Vitamin B1 composition and do not comprise the comparative example 4 that promotes burning fat, promotes energy metabolism composition and compare, its body weight and BMI value have all significantly reduced many.Can confirm that thus diet product of the present invention have the effect that reduces body weight and improve obesity.
Claims (6)
1. diet product is characterized in that: contain hydroxyl lemon lemon acid (hydroxycitric acid) or its esters and carnitine or its esters with and/or the salt of its presoma.
2 presomas that contain carnitine have lysine or its esters or the one or both of methionine.
3. diet product according to claim 1 and 2 is characterized in that: contain coenzyme Q10.
4. diet product according to claim 1 and 2 is characterized in that: contain vitamin C, Vitamin B6, nicotinic acid, irony, adrianol, Rhizoma Zingiberis Recens and Fructus Capsici.
5. according to claim 1,2 or 3 described diet product, it is characterized in that: contain Vitamin B1, Rhizoma Zingiberis Recens and Fructus Capsici.
6. according to any described diet product of claim 1～5, it is characterized in that: have can promote fat combustion and/or accelerate the energy metabolism with and/or effectively improve function such as obesity.
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| Application Number | Priority Date | Filing Date | Title |
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| JP2003108492 | 2003-04-11 | ||
| JP2003108492 | 2003-04-11 | ||
| JP2004007050A JP2004321171A (en) | 2003-04-11 | 2004-01-14 | Food and drink |
| JP2004007050 | 2004-01-14 |
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| CN1535605A true CN1535605A (en) | 2004-10-13 |
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| CNA2004100337257A Pending CN1535605A (en) | 2003-04-11 | 2004-04-09 | Drink and food |
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| JP (1) | JP2004321171A (en) |
| CN (1) | CN1535605A (en) |
| HK (1) | HK1061146A2 (en) |
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| WO2009082883A1 (en) * | 2007-12-26 | 2009-07-09 | Guangzhou Konzern Pharmaceutical Co., Ltd. | Antiobesity composition |
| CN102481271A (en) * | 2009-05-11 | 2012-05-30 | 博格生物***有限责任公司 | Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| US9901542B2 (en) | 2013-09-04 | 2018-02-27 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme Q10 |
| US10376477B2 (en) | 2011-04-04 | 2019-08-13 | Berg Llc | Method of treating or preventing tumors of the central nervous system |
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| JP4534579B2 (en) * | 2004-04-28 | 2010-09-01 | 味の素株式会社 | Lysine-containing anti-obesity or anti-hyperlipidemic food, feed or supplement |
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-
2004
- 2004-01-14 JP JP2004007050A patent/JP2004321171A/en active Pending
- 2004-04-03 HK HK04102445A patent/HK1061146A2/en not_active IP Right Cessation
- 2004-04-09 CN CNA2004100337257A patent/CN1535605A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009082883A1 (en) * | 2007-12-26 | 2009-07-09 | Guangzhou Konzern Pharmaceutical Co., Ltd. | Antiobesity composition |
| CN102481271A (en) * | 2009-05-11 | 2012-05-30 | 博格生物***有限责任公司 | Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| US10351915B2 (en) | 2009-05-11 | 2019-07-16 | Berg Llc | Methods for treatment of oncological disorders using an epimetabolic shifter (Coenzyme Q10) |
| US10519504B2 (en) | 2009-05-11 | 2019-12-31 | Berg Llc | Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| US11028446B2 (en) | 2009-05-11 | 2021-06-08 | Berg Llc | Methods for treatment of oncological disorders using an epimetabolic shifter (coenzyme Q10) |
| US10376477B2 (en) | 2011-04-04 | 2019-08-13 | Berg Llc | Method of treating or preventing tumors of the central nervous system |
| US11452699B2 (en) | 2011-04-04 | 2022-09-27 | Berg Llc | Method of treating or preventing tumors of the central nervous system |
| US10933032B2 (en) | 2013-04-08 | 2021-03-02 | Berg Llc | Methods for the treatment of cancer using coenzyme Q10 combination therapies |
| US9901542B2 (en) | 2013-09-04 | 2018-02-27 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme Q10 |
| US11298313B2 (en) | 2013-09-04 | 2022-04-12 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme Q10 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004321171A (en) | 2004-11-18 |
| HK1061146A2 (en) | 2004-08-13 |
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