CN1493273A - Water less hand disinfecting cleaning agent - Google Patents

Abstract

The present development relates to a liquid cleansing product that effectively reduces the level of microbes on the skin in a relatively short wash time and which dries quickly without causing damage and drying to the skin. The sanitizing cleanser composition comprising an effective amount of alcohol to produce a reduction in microorganisms on the surface of the skin, and an additive to maintain the skin pH in the range of from about 4.0 to about 6.0. The cleanser composition may further include silicone to aid further the drying process, and emollients or oils for skin moisturizing.

Description

No sailor's disinfectant detergent

Cross-reference before the application

It is 09/973 that the request of the application's book gives serial number priority, 327 U.S. Patent application, the serial number that this application requires on October 20th, 2000 to submit to is the priority of 60/241,900 U.S. Patent application, and the latter then provides as the reference file in presents.

Invention field

Do not need water to bring into play anti-microbial effect when involved in the present invention is on being applied to skin, can produce the antimicrobial compositions of continuous action in the part.Specifically, what antimicrobial compositions of the present invention used is a kind of alcohol-based solvent, it can make the microorganism on the skin substantially reduce at once, and the silicone additives that it contains helps to accelerate volatilization process, and the emollient that it contains then can make dermal sensation moistening.

Background of invention

As everyone knows, washing one's hands with soap and hot water is a kind of very effective method that reduces the skin surface microorganism.But, if hand washing is not dried later, the water residue of trace can be concealed microorganism.Certainly, this situation can not cause serious threat to people substantially, but in the environment of hospital, people are very easy to infected, so wish to reduce as far as possible any contaminated danger.

In the past few years, research work mainly concentrates on and how to develop a kind of can not making above the liquid cleaning product that water just can be effectively carries out disinfection to skin.Many this liquid cleaning products all contain the alcoholic content of higher concentration or higher weight percentage ratio.Ethanol can make cleaning product do sooner in use, but also can cause xerosis cutis simultaneously, allows the people be difficult to stand, and can make skin allergy, causes dry and cracked and chafes.

Summary of the invention

This exploitation relates to is not based on the liquid cleaning product of water.When being used for local time, cleaning product can reduce the microorganism on the skin effectively in the relatively shorter time.In addition, this cleaning agent can be volatilized fast, uses repeatedly also can not damage and make xerosis cutis to skin.Also having a benefit is exactly that this cleaning product can bring moistening sensation to skin.

The invention provides a kind of cleanser compositions with anti-microbial disinfection function, it comprises the ethanol of the effective dose that can reduce the skin surface microorganism, a kind of additive that can keep the pH value of skin about 4.0 to 6.0 scopes.Specifically, can add the lactic acid of the effective dose that can help balance skin pH value, pyrogenic silica, sodium lactate or their combination.This cleanser compositions can also comprise emollient or the oils and fats that can accelerate evaporable siloxanes when using and be used for moistening skin.The invention still further relates to and use the antimicrobial compositions that continuous action is arranged as described below to reduce the method for micro organism quantity on the skin.

Detailed description of the preferred embodiments

What the present invention relates to is a kind of non-water base hands sterilization detergent combination.This product is based on ethanol, and has added additive, is used for making the pH value of skin to be maintained at about in 4.0 to 6.0 the scope, so just can reduce the microbial count on the skin, and make skin keep normal flora.Also contain siloxanes in this cleanser compositions, it helps to accelerate volatilization process, and can contain and can make skin feel moistening and fresh emollient.Antimicrobial compositions of the present invention is very effective for microbial numbers on the minimizing skin, simultaneously can also moistening and protection skin.In addition, because this cleaning agent does not contain moisture, compare with other water-based clean products, it also has several special advantages.Inappreciable in view of containing in the present composition composition, perhaps contain moisture hardly, cleanser compositions is more even than water-based cleaner from the volatility on the skin.The humidity of outside air can influence the volatilization of moisture.So the cleanser compositions that contains large quantity of moisture will volatilize very slowly from skin under the humidity condition with higher.Like this, not only require the disinfector to use flip cleanser compositions on the skin of more time, also can stay a kind of being clamminess and clammy sensation.Cleanser compositions of the present invention just can not cause these damages, because do not contain moisture in its composition, and the evaporation rate of ethanol and volatile silicone component is not subjected to the influence of humidity in the air.

The hands disinfectant detergent contains one or more pure constituents, and they can provide the antimicrobial function, helps volatilization, and can be used as solvent.And these alcohols are proved to be the skin that can be used for the people, as ethanol, and isopropyl alcohol or their combination etc.These alcohols are that the concentration with about 60wt.%-90wt.% is present in the cleaning agent.Concentration be present in the cleaning agent.

Hand cleaner also contains one or more additives, so that the pH value of skin remains between about 4.0 to 6.0.These additives comprise for example pyrogenic silica, lactic acid, sodium lactate or their combination.In above-mentioned pH value scope, the micro organism quantity on the skin will reduce, and the normal flora on the skin will keep normal level, can be this cleaning agent and brings potential additional anti-microbial effect.The additive component that also contains effective dose in the cleaning agent is used for keeping the skin pH value expected, and according to the additive that is comprised in the prescription or the combination of additive, the content of additive scope can be approximately between the 0wt.% to 12wt.%.

Also contain one or more siloxy group materials in the prescription of hand cleaner, with helping accelerate volatilization process.The evaporation of the siloxanes of employed effumability institute calorific requirement is littler than ethanol in compositions of the present invention, and does not produce on skin as using the not well cooling effect of the viewed people of making of absolute alcohol component prescription.Comprehensive bactericidal effect in addition, uses silicon oxygen alkyl base mass-energy enough to reduce the surface tension of fluid composition, can provide bigger skin contact like this, thereby will have more fluid and contact, so that can be brought into play better with harmful microorganism.This siloxy group material, as Cyclomethicone (cyclomethicone), trimethylsiloxy silicate (trimethylsiloxy silicate) or their combination, concentration with about 4wt.% to 50wt.%, perhaps more preferably, with the concentration of about 5wt.%, even more preferably be present in the cleaning agent prescription to the concentration of 25wt.% with about 11wt.% to 35wt.%.

In common knowledge as industry, adding wetting agent is in order to help the reservation of liquid in the cleaning agent, is in order to regulate the viscosity of cleaning agent and add thickening agent.In the present invention, any ability that can obviously not change prescription can be used with the wetting agent or the thickening agent of the skin pH value of keeping expectation.Such wetting agent can be with the concentration of about 0wt.% to 5wt.%, and such thickening agent can add to the concentration of 6.5wt.% with about 0wt.%.Thickening agent can be based on cellulosic material, and heating silicon dioxide or their combination are as adding the methylcellulose in the compositions into the concentration of about 0wt.% to 1.5wt.%; With add the pyrogenic silica that goes in the compositions into the concentration of about 0wt.% to 5.0wt.%.

Hand cleaner also can be chosen wantonly and comprise that other antimicrobial is to strengthen the bactericidal effect of ethanol.Typical antimicrobial comprises: parachlorometaxylenol (PCMX), chlorhexidine gluconate (chlorhexidene gluconate) (CHG), triclosan, and quaternary ammonium salt are as the antibacterial of generally acknowledging in Benasept, benzethonium chloride and bromine alkanamine and other industries.The content of these antibacterial in compositions can be selected between about 25wt.% and about 10wt.%, perhaps is applied in the cleanser compositions with a concentration that is considered to play antimicrobial effectiveness.PCMX can be used as a representative and nonrestrictive example, with an anti-microbial effect that is considered to provide safe, add in the compositions into of the present invention to the concentration of about 3.75wt.% with about 2wt.%.

As selection, additives such as emollient and refiner, such as aromatic, coloring agent also can add in the disinfectant detergent prescription in one's hands and goes.Can add emollient or wetting agent, aromatic or coloring agent by the required and acceptable concentration of consumer.For example, can comprise in the prescription that concentration is about the aromatic of 0wt.% to 1.5wt.%, stain or their combination.This prescription can also comprise that concentration is about the emollient of 0wt.% to the interpolation of 5wt.%, as tea tree oil, cannabis oil, aloe, lanoline, Simmondsia chinensis oil, Flos Chrysanthemi, caul-fat, herbaceous plant or their combination, they are added in the cleaning agent and go, and can further improve the humidification of skin.

This product is made like this: ethanol, siloxy group material, wetting agent, lactic acid or sodium lactate are placed in the high capacity mixer at ambient temperature, constantly stir to mix fully up to them.Then an alcohol mixture part is moved on in the independent mixer, and add thickening agent, stir up to mixture retrogradation a little.As selection, pyrogenic silica also can add in the thickening agent mixture, so that mixture thickness more.Then thickening agent mixture and the alcohol mixture that is left are mixed, on and on stir simultaneously.The product that generates will have certain viscosity, make product to distribute by hand pump, just as liquid soap dispenser bottle commonly used.For example, under 25 ℃ temperature conditions, range of viscosities is about 100 centipoises (cp) to 100,000 centipoises.Aromatic can be when adding ethanol to, in the time can obtaining better mixed effect, add.

The cleaning agent of making can be packed applicator into as special applications.Use on the sponge of the scouring brush that uses when for example, this cleaning agent can be added in surgical operation.Then, this scouring hand brush that is soaked with cleaning agent just can be used for carrying out aseptic sterilization preparation to patient by surgical personnel before performing a surgical operation.This product can also be immersed on the handkerchief of fabric or non-woven.Such handkerchief both can have been packed also can several packaging together separately.This handkerchief that is soaked with disinfectant detergent can become a kind of product very easily, is used to clean doctor's hands or the patient is being checked part preceding or inspection back cleaning patient.

Below these embodiment are representational examples of hand cleaner manufactured according to the present invention.The antimicrobial properties data of some cleaning agent also are provided, and the cleaning agent that is provided prescription only is illustrative purposes, but not the scope of the invention is imposed any restrictions.

Embodiment 1: this hands disinfectant detergent is mixed with like this: it contains the dehydrated alcohol (the 3%th, isopropyl alcohol) of the 70wt.% that has an appointment, the Dow Corning of about 18.6.wt% ^345 Fluid (Cyclomethicone), the isopropyl myristate of about 4.5wt.%, the lactic acid of about 1.5wt.%, the sodium lactate of about 1.5wt.% (40% is in the state of activation), the Dow Corning of about 1.3wt.% ^749 (Cyclomethicone and trimethylsiloxy silicate products), the Dow Methocel of about 0.6wt.% ^OS (cellulose methylates), and the Cabosil M5 pyrogenic silica of about 2.0wt.%, these all can buy stock from Cabot Corporation company.This product is made like this: at ambient temperature, with dehydrated alcohol, 345Fluid, isopropyl myristate, lactic acid, sodium lactate, and Dow Corning749 is placed on one and equipped at least one agitator, perhaps in the high capacity blending tank of hybrid blade, stirs till this alcohol mixture evenly.Then about 30% alcohol mixture is moved on to one independent, be equipped with in the mixer of hybrid blade, add Methocel ^, stir up to mixture retrogradation a little.Then, add pyrogenic silica to Methocel ^In the mixture, so that mixture becomes thicker.Then with pyrogenic silica/Methocel ^Mixture is admixed together with remaining alcohol mixture, ceaselessly stirs, and fuses in alcohol mixture fully up to the pyrogenic silica mixture.The pH value of the product of making is 4.5, and the viscosity when temperature is 25 ℃ of left and right sides is about 350cp.

Embodiment 2: this hands disinfectant detergent is mixed with like this: it contains the dehydrated alcohol (the 3%th, isopropyl alcohol) of the 77.6wt.% that has an appointment, the Dow Corning of about 15.5.wt% ^345 Fluid (Cyclomethicone), the isopropyl myristate of about 1.5wt.%, the sodium lactate of about 3.6wt.% (40% is in the state of activation), about 1.0wt.%Dow Corning ^749 (Cyclomethicone and trimethylsiloxy silicate product, the Dow Methocel of about 0.5wt.% ^The aromatic of OS and about 0.3wt.%.This product is with dehydrated alcohol, and 345 solution, isopropyl myristate, sodium lactate, Dow Corning749 and aromatic are placed on to mix in the high capacity blending tank and make at ambient temperature.At least will equip an agitator in the blending tank, perhaps one is mixed stirring vane, be stirred to always alcohol mixture evenly till.Then about 30% alcohol mixture being moved on to independent being equipped with mixes Methocel ^Mix with remaining alcohol mixture, continue to stir, up to Methocel ^Mixture fuses in alcohol mixture fully.The pH value of the product of making is 4.3, and the viscosity when temperature is 25 ℃ of left and right sides is about 340cp.

Embodiment 3: except the tea tree oil that uses about 1.5wt.% substitutes dehydrated alcohol (3% is isopropyl alcohol) this point difference of about 1.5wt.%, the product preparation method among the preparation method of this hands disinfectant detergent and the embodiment 2 is just the same.It is as shown in the embodiment 2, adds in the alcohol mixture with tea tree oil and makes.The pH value of the product of making is 4.4, and the viscosity of temperature when being 25 ℃ of left and right sides is about 360cp.

Embodiment 4: except the cannabis oil that uses about 1.8wt.% substitutes dehydrated alcohol (3% is isopropyl alcohol) this point difference of about 1.8wt.%, product preparation method among the preparation method of this hands disinfectant detergent and the embodiment 2 is just the same, and it adds in the alcohol mixture with cannabis oil shown in embodiment 2 and makes.The pH value of the product of making is 4.3, and the viscosity when temperature is about 25 ℃ is 350cp.

Embodiment 5: except at the tea tree oil that uses about 1.0wt.% with approximately the cannabis oil of 0.5wt.% substitutes the dehydrated alcohol (3% is isopropyl alcohol) of about 1.5wt.% this point is different, the product preparation method among the preparation method of this hands disinfectant detergent and the embodiment 2 is just the same.Shown in embodiment 2, it adds in the alcohol mixture with tea tree oil and cannabis oil and makes.The pH of the product of making is 4.3, and the viscosity when temperature is about 25 ℃ is 365cp.

Additional embodiment: prepare the complementary element prescription of several hands disinfectant detergents here according to said procedure, seen table 1 for details.About following form is asked for an interview in the composition and the comment of outward appearance aesthetic qualities of prescription.Unit is the wt.% of total amount.We notice E29 very with interest, and E31, the prescription of E32 and E33 have produced an independent product.This may be because the concentration of ethanol is too low, has only about 40%, and it is lower than concentration of the presently claimed invention.

Table 1

E0???????E1?????????E2????????E3????????E4????????E5???????E6?????????E7

Ethanol, SD3A 77.6 74.70 75.30 76.82 75.00 75.00 76.82 77.4

Isopropyl alcohol----7.10 6.10--

Propanol--------

Butanols--------

Phenethanol--------

Benzyl alcohol--------

PCMX(99％)????????????-???????3.75???????3.00??????1.00???????-?????????-????????-??????????-

CHG (concentration is 20% in the water)--------

Triclosan (100%)------1.00-

QAC-

Benzethonium chloride

(concentration is 50% in the water)-------0.26

Benasept--------

(100％)???????????????-????????-??????????-?????????-?????????-?????????-????????-??????????-

Cetrimide--------

DC345 liquid 15.5 14.92 15.02 15.35 11.00 12.00 15.35 15.46

DC 200 liquid, 0.65cst--------

Propylene glycol--------

Glycerol--------

Sodium lactate 3.6 3.46 3.49 3.57 3.60 3.60 3.57 3.59

Isopropyl myristate 1.5 1.44 1.45 1.49 1.50 1.50 1.49 1.50

DC749????????????????1.0??????0.96???????0.97??????0.99??????1.00??????1.00?????0.99???????1.00

Aloe?Vera?Extract?????-????????-??????????-?????????-?????????-?????????-????????-??????????-

Methocel?OS??????????0.5??????0.48???????0.48??????0.49??????0.50??????0.50?????0.49???????0.50

Spice 0.3 0.29 0.29 0.29 0.30 0.30 0.29 0.29

100.00???100.00?????100.00????100.00????100.00????100.00???100.00?????100.00

Outward appearance settled solution settled solution settled solution settled solution settled solution settled solution settled solution settled solution

Table 1 (continuing)

E8????????E9??????????E10??????E11??????????E12????????E13

Ethanol, SD3A 77.4 75.30 75.00 75.00 75.00 75.00

Isopropyl alcohol------

Propanol---5.00--

Butanols----5.00-

Phenethanol-----5.00

Benzyl alcohol------

PCMX(99％)?????????-?????????-??????????3.00??????-????????????-??????????-

CHG (concentration is 20% in the water)------

Triclosan (100%)------

QAC-

Benzethonium chloride

(concentration is 50% in the water)--0.30---

Benasept 0.26-----

(100％)

Cetrimide-3.00----

DC 345 liquid 15.46 15.02 15.02 13.10 13.10 13.10

DC 200 liquid, 0.65cst------

Propylene glycol------

Glycerol------

Sodium lactate 3.59 3.49 3.49 3.60 3.60 3.60

Isopropyl myristate 1.50 1.45 1.45 1.50 1.50 1.50

DC749?????????????1.00??????0.97????????0.97?????1.00?????????1.00??????1.00

Aloe?Vera?Extract??-?????????-???????????-????????-????????????-??????????-

Methocel?OS???????0.50??????0.48????????0.48?????0.50?????????0.50??????0.50

Spice 0.29 0.29 0.29 0.3 0.3 0.3

100.00????100.00??????100.00???100.00???????100.00????100.00

Outward appearance settled solution settled solution settled solution settled solution settled solution settled solution

Table 1 (continuing)

E14???????E15???????E16???????E17???????E18???????E19???????E20???????E21

Ethanol, SD3A 75.00 75.00 75.00 75.00 75.00 75.00 75.00 75.00

Isopropyl alcohol----8.10---

Propanol--------

Butanols--------

Phenethanol-2.50 2.50-----

Benzyl alcohol 5.00 2.50-----3.50

PCMX(99％)??????????-?????????-????????2.50???????-?????????-?????????-?????????-????????2.50

CHG (concentration is 20% in the water)--------

Triclosan (100%)--------

QAC-

Benzethonium chloride

(concentration is 50% in the water)--------

Benasept

(100％)?????????????-?????????-?????????-?????????-?????????-?????????-?????????-?????????-

Cetrimide--------

DC 345 liquid 13.10 13.10 13.10 13.10 10.00 8.10 8.10 8.10

DC 200 liquid, 0.65cst-----10.00 5.50-

Propylene glycol---5.00--5.50 5.00

Glycerol--------

Sodium lactate 3.60 3.60 3.60 3.60 3.60 3.60 3.60 3.60

Isopropyl myristate 1.50 1.50 1.50 1.50 1.50 1.50 1.50 1.50

DC749??????????????1.00??????1.00??????1.00???????-????????1.00??????1.00???????-?????????-

Aloe?Vera?Extract???-?????????-?????????-????????1.00???????-?????????-?????????-?????????-

Methocel?OS????????0.50??????0.50??????0.50??????0.50??????0.50??????0.50??????0.50??????0.50

Spice 0.3 0.30 0.30 0.30 0.30 0.30 0.30 0.30

100.00????100.00????100.00????100.00????100.00????100.00????100.00????100.00

Outward appearance settled solution settled solution settled solution settled solution settled solution settled solution settled solution settled solution

Table 1 (continuing)

E22??????E23?????????E24??????E25???????E26???????E27???????E28

Ethanol, SD3A 75.00 85.00 80.00 85.00 85.00 60.00 46.55

Isopropyl alcohol--5.00----

Propanol-------

Butanols-------

Phenethanol----1.75--

Benzyl alcohol 3.50------

PCMX(99％)?????????2.50???????-?????????-?????????-????????2.90???????-?????????-

CHG (concentration is 20% in the water)-------

Triclosan (100%)-------

QAC-??????????????????????????????????????????????????????????????????-?????????-

Benzethonium chloride

(concentration is 50% in the water)----0.35--

Benasept

(100％)?????????????-?????????-?????????-?????????-?????????-?????????-?????????-

Cetrimide-------

DC 345 liquid 8.10 8.10 8.10 4.10 4.10 33.10 46.55

DC 200 liquid, 0.65cst 2.50------

Propylene glycol 2.50--5.00---

Glycerol-------

Sodium lactate 3.60 3.60 3.60 3.60 3.60 3.60 3.60

Isopropyl myristate 1.50 1.50 1.50 1.50 1.50 1.50 1.50

DC749???????????????-????????1.00??????1.00???????-????????0.00??????1.00??????1.00

Aloe?Vera?Extract???-?????????-?????????-?????????-

Methocel?OS????????0.50??????0.50??????0.50??????0.50??????0.50??????0.50??????0.50

Spice 0.30 0.30 0.30 0.30 0.30 0.30 0.30

100.00????100.00????100.00????100.00????100.00????100.00????100.00

Outward appearance settled solution settled solution settled solution settled solution settled solution settled solution settled solution

Table 1 (continuing)

E29?????E30???????E31?????E32?????E33?????E34???????E35???????E36

Ethanol, SD3A 30.00 40.00 31.00 31.00 31.00 20.00 35.00 35.00

Isopropyl alcohol-----20.00--

Propanol--------

Butanols--------

Phenethanol-------5.00

Benzyl alcohol------5.00-

PCMX(99％)???????????-???????-?????????-???????-???????-???????-?????????-?????????-

CHG (concentration is 20% in the water)--------

Triclosan (100%)--------

QAC-

Benzethonium chloride

(concentration is 50% in the water)--------

Benasept

(100％)??????????????-???????-?????????-???????-???????-???????-?????????-?????????-

Cetrimide--------

DC 345 liquid 63.10 53.10 31.00 31.00 46.50 53.00 53.00 26.50

DC 200 liquid, 0.65cst-------26.50

Propylene glycol--31.00 15.50 15.50---

Glycerol---15.50----

Sodium lactate 3.60 3.60 3.60 3.60 3.60 3.60 3.60 3.60

Isopropyl myristate 1.50 1.50 1.60 1.60 1.60 1.60 1.60 1.60

DC749????????????????1.00????1.00??????-???????-???????-???????1.00??????1.00??????1.00

Aloe?Vera?Extract????-???????-?????????1.00????1.00????1.00????-?????????-?????????-

Methocel?OS??????????0.50????0.50??????0.50????0.50????0.50????0.50??????0.50??????0.50

Spice 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30

100.00??100.00????100.00??100.00??100.00??100.00????100.00????100.00

Outward appearance layering settled solution layering layering layering settled solution settled solution settled solution

Table 1 (continuing)

E37????????E38??????E39???????E40???????E41???????E42

Ethanol, SD3A 46.50 54.50 54.00 75.00 75.00 75.00

Isopropyl alcohol------

Propanol------

Butanols------

Phenethanol 6.00----5.00

Benzyl alcohol------

PCMX(99％)??????????3.75???????-????????3.00???????-?????????-????????3.75

CHG (concentration is 20% in the water)------

Triclosan (100%)------

QAC-

Benzethonium chloride

(concentration is 50% in the water)--0.75---

Benasept

(100％)??????????????-?????????-?????????-?????????-?????????-?????????-

Cetrimide-3.00----

DC 345 liquid 35.00 31.00 31.00 8.10 8.10 16.25

DC 200 liquid, 0.65cst------

Propylene glycol 2.50 5.00 5.00 10.00 5.00-

Glycerol----5.00-

Sodium lactate 3.20 3.60 3.20 3.60 3.60-

Isopropyl myristate 1.25 1.60 1.25 1.50 1.50-

DC749????????????????-?????????-?????????-?????????-?????????-?????????-

Aloe?Vera?Extract???1.00??????1.00??????1.00??????1.00??????1.00???????-

Methocel?OS?????????0.50??????0.00??????0.50??????0.50??????0.50???????-

Spice 0.30 0.30 0.30 0.30 0.30-

100.00????100.00????100.00????100.00????100.00????100.00

Outward appearance settled solution settled solution settled solution settled solution settled solution

Antimicrobial properties research: the antimicrobial efficacy of hands disinfectant detergent can be assessed with various known methods.For example, can come definite minimum inhibitory concentration that can suppress the cleaning agent of growth of microorganism, also can measure the ability that known microorganisms quantity is killed in cleaning agent fast with a kind of quick sterilization research with minimum inhibitory concentration research.These researchs can utilize the common microorganism and the fungus of listing in table 2 to carry out.

Table 2

Organism	??ATCC	Organism	ATCC
Aspergillus niger (Aspergillus niger)	??6275	Bacillus cereus (Bacillus cereus)	1178
				Streptococcus pneumoniae (Streptococcus pneumoniae)	? ??6303 ?	Staphylococcus epidermidis (Staphyloceus epidermidis)	? 12228 ?
Staphylococcus aureus (staphyloccus aureus)	? ??6538 ?	This special Salmonella of monocyte hyperplasia (Listeria monocytogenes)	? 15313 ?
				Salmonella typhimurium (salmonella typhi)	? ??6539 ?	Haemophilus influenzae (Haemophilus influenzae)	? 19418 ?
Proteus mirabilis belongs to (Proteus mirabilis)	? ??7002 ?	Candida parapsilosis (Candida parapsilosis)	? 22019 ?
				Bacillus pyocyaneus (Pseudomonas aeruginosa)	? ??9027 ?	Campylobacter jejuni (Campylobacter jejuni)	? 33560 ?
White mycocandida (Candida albicans)	? ??10231 ?	Staphylococcus aureus (Staphyloccus aureus) (MRSA)	? 33592 ?
				Escherichia coli (Escherichia coli)	? ??11229 ?	Escherichia coli (Escherichia coli) 0157:H7	? 43895 ?
Klebsiella pneumonia ozena subspecies (Klebsiella pneumonia (sub. species azaenae)	? ? ??11296	Enterococcus faecalis (Enterococcus faecium) (VRE)	? ? 51559

Minimum inhibitory concentration research

Minimum inhibitory concentration (MIC) is the least concentration that an antimicrobial can suppress growth of microorganism.The a series of dilution of combating microorganisms experiment material is carried out in gravy or agar, then the organism of a normal concentration is put into the agar culture dish that contains the dilution experiment material.Test with multiple organism at this material, to determine the maximum dilution degree of this material under the situation that keeps antimicrobial efficacy.

Specifically, for measuring minimal inhibitory concentration the product among the embodiment 2 (" product 2 ") is tested, this experiment is to be under the situation of 1: 2 (by weight) according to certain program at experiment material dilution factor, puts into that Mueller-Hinton gravy or Brain-Heart Infusion Broth gravy carries out.A capacity is in first hole of the diluent of the equal portions of the 200 μ L round that is added to microtitration plate.Then, the dilution of product is from first hole, and the various dilution factors of testing material are contained in every other hole: 1: 2, and 1: 4,1: 8,1: 10,1: 20,1: 50,1: 80,1: 100,1: 150 and 1: 200.In the control wells of microorganism and medium is also included within.

The objective microbe organism is scraped off from culture dish, be about 1.0 * 10 with density then ⁵The cell resuspending is in phosphate buffer.Then each is tested and organicly a kind ofly be about 5 * 10 ⁴The inoculum of CFU (colony-forming units) is all put into the experimental port that forms a line of microtitration plate, and mixes, and microtitration plate was being hatched about 23 hours under 37 ± 2 ℃ the temperature.Table 3 has been summed up microbial growth in the experimental port, with " (+) expression has been grown, not growth of (0) expression ".MIC is considered to repeated trials and shows the wherein complete repressed minimum diluted concentration of microbial growth.

Table 3

Organism	Repeat	The diluent in experiment material hole										Contrast
														? ?? ????ATCC ?	? ????1∶2 ?	? ????1∶4 ?	? ????1∶8 ?	? ????1∶10 ?	? ????1∶20 ?	? ????1∶50 ?	? ????1∶80 ?	? ????1∶100 ?	? ????1∶150 ?	? ????1∶200 ?	Microorganism	Medium
????6303		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????6303													????2	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????6538		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????6538													????2	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????6539		????1	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????6539													????2	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????0
????7002		????1	????0	????0	????+	????0	????+	????+	????+	????+	????+	????+	????+														????0
	????7002													????2	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????0
????9027		????1	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????9027													????2	????0	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????0
????10231 a		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????10231 a													????2	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????11229		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????11229													????2	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????11296		????1	????0	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+														????0
	????11296													????2	????0	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????0
????11778 b		????1	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????11778 b													????2	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????0
????12228		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????12228													????2	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????15313		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????15313													????2	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????19418		????1	????0	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+														????0
	????19418													????2	????0	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????0
????33560 c		????1	????0	????0	????+	????0	????+	????+	????+	????+	????+	????+	????+														????0
	????33560 c													????2	????0	????0	????+	????0	????+	????+	????+	????+	????+	????+	????+	????0
????33592		????1	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????33592													????2	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0
????43895		????1	????0	????0	????+	????0	????+	????+	????+	????+	????+	????+	????+														????0
	????43895													????2	????0	????0	????0	????+	????+	????+	????+	????+	????+	????+	????+	????0
????51559		????1	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????+														????0
	????51559													????2	????0	????+	????+	????+	????+	????+	????+	????+	????+	????+	????+	????0

25 ± 2 ℃ rather than 37 ± 2 ℃ of a incubation temperatures

30 ± 2 ℃ rather than 37 ± 2 ℃ of b incubation temperatures

C is at 5%CO ₂Atmospheric environment under and under 42 ± 2 ℃ incubation temperature, brooding time is about 25.50 hours

Quick sterilization research

Quick sterilization research is used to measure the ability that a kind of antimicrobial reduces known microorganisms quantity fast.A sample aliquot of antimicrobial experiment material was contacted with the experiment microorganism or the mycete of a concentration known in one period scheduled time.With the substances neutralization, just can determine the concentration of survival microorganism then, the effect of antimicrobial then is to calculate on the basis of the percentage ratio of the quantity of can not surviving that is exposed to the microorganism under the antimicrobial.

For example, the product among the embodiment 2 (" product 2 ") is by estimating its quick sterilization activity according to a scheme.It is in 25 ± 1 ℃ the aseptic glass jar that the sample aliquot of a 5mL of still undiluted in this scheme " product 2 " is placed in a temperature, and one chosen in advance, can output be about 10 ⁸The 0.5ml sample of the microorganism gravy culture fluid of the microorganism diluent of CFU/mL mixes with the sample aliquot of antimicrobial material.After a period of time (" open-assembly time ") of placing regulation, the nertralizer solution of 45mL is added in the glass jar, and stirs for 60 seconds.Carry out about 10 from having ^-1-10 times of serial dilutions are to reach about 10 ^-6Remove 1ml equal portions diluent in the jar of the microorganism diluent of dilution.These diluents are put into the double culture dish with " Pour Plate Technique " technology.The culture dish inversion is also carried out 48 ± 2 hours hatching under 35 ± 2 ℃ temperature conditions.Along with the carrying out of hatching, the colony forming unit number of organic every mL (CFU/mL) of survival is counted, and compares with the colony counts in when beginning.In each organic check sample is included in, except product 2 the starting stage of program is not added into, exposure time also carries out according to same program basically.Table 4 has been listed the microorganism of using in quick sterilization research, the unit number that every milliliter of (mL) bacterium colony of control sample and laboratory sample generates (the double report is provided), and by the reduction percentage ratio and the log of organism counting ₁₀The effect of the product that reduction determined 2.

Table 4

Organism ATCC#	Open-assembly time (second)	The counting (CFU/mL) of contrast	Counting to laboratory sample		% reduces	??Log 10Reduce
							Repeat 1 (CFU/mL)	Repeat 2 (CFU/mL)
??06275	????15	????2.0×10 7			????3.2×10 3	????3.4×10 3	????99.98	????3.78
			??06275	????30					????1.7×10 7	????1.4×10 3	????2.3×10 4	????99.93	????3.15
??06275	????60	????1.4×10 7			????1.8×10 4	????5.5×10 3	????99.91	????3.07
??06303	????15	????9.7×10 6			????6.0×10 1	????3.3×10 3	????99.98	????3.76
			??06303	????30					????1.4×10 7	????6.1×10 2	????1.1×10 2	??＞99.99	??＞4.59
??06303	????60	????9.9×10 6			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.00

Table 4 (continuing)

Organism ATCC#	Open-assembly time (second)	The counting (CFU/mL) of contrast	Counting to laboratory sample		% reduces	? ??Log 10Reduce
							Repeat 1 (CFU/mL)	Repeat 2 (CFU/mL)
????06538	????15	????3.4×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.53
			????06538	????30					????3.1×10 7	????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.49
????06538	????60	????3.4×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.53
????06538	????15	????6.0×10 7			????5.0×10 4	????8.4×10 3	????99.95	????3.23
			????06538	????30					????3.7×10 7	????1.6×10 4	????＜1.0×10 1	??＞99.98	??＞3.67
????06538	????60	????4.6×10 7			????1.2×10 2	????5.0×10 1	??＞99.99	???5.73
????06539	????15	????1.9×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.28
			????06539	????30					????1.6×10 7	????6.0×10 3	????＜1.0×10 1	??＞99.98	??＞3.72
????06539	????60	????2.3×10 7			????3.5×10 3	????2.7×10 2	????99.99	????4.08
????07002	????15	????2.0×10 7			????＜1.0×10 1	????1.4×10 3	??＞99.99	??＞4.46
			????07002	????30					????2.6×10 7	????1.1×10 4	????＜1.0×10 1	??＞99.98	??＞3.67
????07002	????60	????2.3×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.36
????09027	????15	????2.0×10 7			????2.9×10 2	????＜1.0×10 1	??＞99.99	??＞5.12
			????09027	????30					????1.4×10 8	????2.4×10 5	????＜1.0×10 1	????99.91	????3.07
????09027	????60	????1.3×10 8			????＜1.0×10 1	????2.8×10 4	??＞99.99	??＞3.96
????09027	????15	????1.3×10 8			????7.0×10 4	????2.3×10 4	????99.97	????3.45
			????09027	????30					????2.0×10 7	????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.30
????09027	????60	????2.8×10 7			????＜1.0×10 1	????1.0×10 1	??＞99.99	??＞6.45
????10231	????15	????1.0×10 6			????1.5×10 4	????1.4×10 3	????99.18	????2.09
			????10231	????30					????1.0×10 6	????8.6×10 2	????1.5×10 1	????99.96	????3.36
????10231	????60	????9.8×10 5			????1.2×10 2	????3.4×10 3	????99.82	????2.73
????10231	????15	????1.1×10 6			????7.5×10 1	????1.3×10 3	????99.94	????3.20
			????10231	????30					????9.8×10 5	????1.8×10 4	????＜1.0×10 1	??＞99.08	??＞2.04
????10231	????60	????8.8×10 5			????2.8×10 2	????1.2×10 2	????99.98	????3.64
????11229	????15	????4.0×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.60
			????11229	????30					????2.8×10 7	????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.45
????11229	????60	????3.6×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.56
????11296	????15	????2.4×10 7			????2.0×10 3	????1.6×10 3	????99.99	????4.12
			????11296	????30					????2.0×10 7	????1.1×10 3	????6.5×10 1	????99.99	????4.54

Table 4 (continuing)

Organism ATCC#	Open-assembly time (second)	The counting (CFU/mL) of contrast	Counting to laboratory sample		% reduces	? ??Log 10Reduce
							Repeat 1 (CFU/mL)	Repeat 2 (CFU/mL)
????11296	????60	????2.1×10 7			????3.8×10 3	????＜1.0×10 1	??＞99.99	??＞4.04
????11778	????15	????8.2×10 5			????1.8×10 3	????＜1.0×10 1	??＞99.89	??＞2.96
			????11778	????30					????8.2×10 5	????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞4.91
????11778	????60	????8.6×10 5			????2.6×10 3	????1.0×10 1	????99.85	????2.82
????12228	????15	????1.4×10 7			????9.6×10 3	????8.4×10 4	????99.66	????2.48
			????12228	????30					????1.2×10 7	????1.5×10 3	????5.0×10 4	????99.78	????2.66
????12228	????60	????1.4×10 7			????1.5×10 1	????7.2×10 3	????99.97	????3.59
????15313	????15	????4.3×10 7			????3.0×10 5	????1.8×10 5	????99.44	????2.25
			????15313	????30					????4.7×10 7	????＜1.0×10 1	????6.9×10 3	??＞99.99	??＞4.14
????15313	????60	????4.8×10 7			????3.4×10 4	????1.7×10 5	????99.79	????2.68
????19418	????15	????1.7×10 7			????3.5×10 2	????4.7×10 3	????99.99	????3.85
			????19418	????30					????1.5×10 7	????1.2×10 4	????5.0×10 4	????99.79	????2.69
????19418	????60	????1.6×10 7			????1.0×10 3	????9.8×10 3	????99.97	????3.47
????22019	????15	????9.0×10 5			????1.0×10 3	????6.0×10 3	????99.61	????2.41
			????22019	????30					????9.5×10 5	????6.2×10 2	????5.4×10 2	????99.94	????3.22
????22019	????60	????1.6×10 6			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞5.20
????33592	????15	????1.4×10 7			????7.4×10 4	????2.6×10 5	????98.78	????1.92
			????33592	????30					????1.1×10 7	????＜1.0×10 1	????2.2×10 3	??＞99.98	??＞4.00
????33592	????60	????1.4×10 7			????1.6×10 3	????1.8×10 3	????99.99	????3.92
????33650	????15	????5.6×10 6			????6.0×10 2	????1.8×10 3	????99.98	????3.67
			????33650	????30					????4.9×10 6	????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞5.69
????33650	????60	????6.2×10 6			????3.0×10 1	????＜1.0×10 1	??＞99.99	??＞5.19
????43895	????15	????4.2×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.62
			????43895	????30					????4.8×10 7	????5.3×10 3	????＜1.0×10 1	??＞99.99	??＞4.27
????43895	????60	????3.0×10 7			????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.48
????51559	????15	????4.0×10 7			????4.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.02
			????51559	????30					????4.6×10 7	????＜1.0×10 1	????＜1.0×10 1	??＞99.99	??＞6.66
????51559	????60	????8.8×10 5			????4.0×10 3	????＜1.0×10 1	??＞99.99	??＞4.30

From the reading of last table, those skilled in the art can characteristic according to the present invention dream up some extension products, for example, can increase other additives on the prescription of this product, to increase the acceptance level of consumer.Such as adding stain, coloring agent, skin softening agents; Derma-Guard is as substance having sun-screening function, for another example for the drying property of alleviation of alcohol; perhaps change the uncomfortable touch feeling and the xerosis cutis that cause by high alcohol content, can add other siloxanes or non-silicone chemical compound or solvent.The mutation product of these and even other this cleaning agent all meets the spirit and scope in the claim of enclosing.

Claims (60)

1. no sailor's disinfectant detergent, it comprises: about 60wt.% is to one or more organic alcohols of about 90wt.%, about 5wt.% is to one or more siloxy group materials of about 35wt.%, one or more wetting agents of maximum about 5wt.%, one or more of about 12wt.% are kept the additive of skin pH value at most, and also contain the thickening agent that one or more add with certain concentration, so that this product keeps 100cp to 100, the viscosity of 000cp under about 25 ℃ temperature.

2. the hand cleaner of claim 1, wherein contained alcohol is selected from dehydrated alcohol, isopropyl alcohol, propanol, butanols; Phenethanol, benzyl alcohol and their combination.

3. the hand cleaner of claim 1, wherein used pH value keep additive that the pH value of skin is maintained at about between 4.0 to 6.0.

4. the hand cleaner of claim 3, wherein said pH value keep additive to be selected from pyrogenic silica, lactic acid, lactate sodium and their combination.

5. the hand cleaner of claim 3, it is pyrogenic silica that wherein said pH value keeps additive.

6. the hand cleaner of claim 5, wherein said pyrogenic silica are to add with the concentration of maximum about 5.0wt.%.

7. the hand cleaner of claim 3, it is lactic acid that wherein said pH value keeps additive.

8. the hand cleaner of claim 7, wherein said lactic acid are to add with the concentration of maximum about 5.0wt.%.

9. the hand cleaner of claim 6, the wherein said lactic acid that adds with the concentration of maximum about 5.0wt.% that also comprises.

10. the hand cleaner of claim 3, it is sodium lactate that wherein said pH value keeps additive.

11. being the concentration with maximum about 2.0wt.%, the hand cleaner of claim 10, wherein said sodium lactate add.

12. the hand cleaner of claim 1, wherein said siloxy group material is a Cyclomethicone, trimethylsiloxy silicate and a kind of their chemical compound.

13. the hand cleaner of claim 1, wherein said wetting agent is an isopropyl myristate.

14. the hand cleaner of claim 1, wherein said thickening agent are the thickening agents of cellulose base.

15. the hand cleaner of claim 14, wherein said thickening agent is a methylcellulose.

16. the hand cleaner of claim 1, wherein said thickening agent is a pyrogenic silica.

17. the hand cleaner of claim 16, wherein said pyrogenic silica are to occur with the concentration of maximum about 5wt.%.

18. the hand cleaner in the claim 1 also contains a kind of aromatic.

19. the hand cleaner of claim 18, wherein said aromatic are to add with the concentration of maximum about 1.5wt.%.

20. the hand cleaner in the claim 1 also includes a kind of coloring agent.

21. the hand cleaner in the claim 1 also includes one or more emollient.

22. the hand cleaner of claim 21, wherein said emollient are to add with the concentration of maximum about 5wt.%.

23. the emollient of the hand cleaner in the claim 22 is selected from tea tree oil, cannabis oil, Aloe base oil and their combination.

24. the scope of the viscosity of the hand cleaner in the claim 1 when temperature is 25 ℃ is to 450cp from about 250cp.

25. the hands disinfectant detergent mainly contains following composition:

A) alcohol mixture, it be by concentration be about 60wt.% to about 90wt.% one or more alcohol with concentration be about 5wt.% one or more siloxy group materials to about 35wt.%, concentration is about the isopropyl myristate of 5wt.% at most, be about the lactic acid of maximum 5.0wt.% with concentration and sodium lactate that concentration is about 2.0wt.% at most mixes under ambient temperature conditions, and make after reaching evenly, and

B) thickened mixt is by the described alcohol mixture of a part is moved on in the independent mixer, and adds the methylcellulose that concentration is about 1.5wt.% at most, ceaselessly stirs simultaneously, make up to mix homogeneously,

Wherein this thickened mixt mixes with this alcohol mixture at ambient temperature, and ceaselessly stirs, and reaches the scope of 250cp to about 450cp approximately up to the viscosity of product under 25 ℃ temperature; This alcohol mixture and this thickened mixt are all made under water-free condition.

26. the hand cleaner in the claim 25, wherein said alcohol is selected from dehydrated alcohol, isopropyl alcohol, propanol, butanols; Phenethanol, benzyl alcohol and their combination.

27. the hand cleaner of claim 25, wherein said siloxy group material is a Cyclomethicone, trimethylsiloxy silicate and their combination.

28. the hand cleaner of claim 25 also contains the pyrogenic silica of the about at most 5wt.% of concentration, it is added in the thickened mixt.

29. also containing with the concentration of maximum about 1.5wt.%, the hand cleaner in the claim 25 adds aromatic in this alcohol mixture to.

30. the hand cleaner of claim 25 also contains one or more emollient of the about at most 5wt.% of concentration, this emollient is selected from tea tree oil, cannabis oil, aloe and their compositions, and this emollient is added in this alcohol mixture.

31. a method for preparing the hands disinfectant detergent mainly may further comprise the steps:

A) concentration is about 60wt.% and is about 5wt.% one or more siloxy group materials to about 35wt.% to one or more alcohols of about 90wt.% and concentration, be about the isopropyl myristate of 5wt.% at most with concentration, be about the lactic acid of 5.0wt.% at most with concentration and sodium lactate that concentration is about 2.0wt.% at most mixes at ambient temperature, until mix homogeneously

B) go in the part of formed mixture in " a) " step above the methylcellulose that concentration is about 1.5wt.% at most adds to, be modulated into uniform mixture, and

C) at ambient temperature, in " a) " step in the formed mixture, constantly stir above the methylcellulose mixture added to, a kind of under 25 ℃ temperature until making, viscosity is about the product of 250cp to 450cp.

32. the hand cleaner in the claim 31, wherein said alcohols is selected from dehydrated alcohol, isopropyl alcohol, propanol, butanols; Phenethanol is in benzyl alcohol and their combination.

33. the hand cleaner in the claim 31, wherein said siloxy group material is a Cyclomethicone, trimethylsiloxy silicate and their combination.

34. the hand cleaner in the claim 31 also contains the pyrogenic silica of the about at most 5wt.% of a kind of concentration, it is added in the thickened mixt.

35. also containing with the concentration of maximum about 1.5wt.%, the hand cleaner in the claim 31 adds aromatic in this alcohol mixture to.

36. the hand cleaner in the claim 31 also contains one or more emollient of the about at most 5wt.% of concentration, this emollient is selected from tea tree oil, cannabis oil, aloe and their combination, and this emollient is added in this alcohol mixture.

37. a hands disinfectant detergent comprises:

Concentration is about 60wt.% one or more alcohols to 90wt.%,

Concentration is about 11wt.% one or more siloxy group materials to 35wt.%,

Concentration is about one or more wetting agents of 5wt.% at most,

Concentration is about one or more antimicrobials of 10wt.% at most

One or more skin pH value that concentration is about 12wt.% at most keep additive; And

The thickening agent that one or more add with certain concentration, it makes this product produce 100cp to 100, the viscosity of 000cp under 25 ℃ temperature.

38. the hand cleaner of claim 37, wherein said alcohols is selected from dehydrated alcohol, isopropyl alcohol, propanol, butanols; Phenethanol, benzyl alcohol and their combination.

39. the hand cleaner in the claim 37, wherein said pH value keep additive that the skin pH value is maintained at about in 4.0 to 6.0 the scope.

40. the hand cleaner in the claim 39, wherein said pH value keep additive to be selected from and include pyrogenic silica, lactic acid, sodium lactate and their combination.

41. it is the pyrogenic silica that adds with the concentration of maximum about 5wt.% that the hand cleaner in the claim 40, wherein said pH value keep additive.

42. it is the lactic acid that adds with the concentration of maximum about 5.0wt.% that the hand cleaner in the claim 40, wherein said pH value keep additive.

43. the hand cleaner in the claim 41 also contains the lactic acid that adds with the concentration of maximum about 5.0wt.%.

44. it is the sodium lactate that the concentration with maximum about 2.0wt.% adds that the hands in the claim 40 cleaning, wherein said pH value keep additive.

45. the siloxy group material of the hand cleaner in the claim 37 is a Cyclomethicone, trimethylsiloxy silicate and their combination.

46. the hand cleaner in the claim 37, wherein said wetting agent is an isopropyl myristate.

47. the hand cleaner in the claim 37, wherein said thickening agent are the cellulose base thickening agents.

48. the hand cleaner in the claim 47, wherein thickening agent is a methylcellulose.

49. hand cleaner in the claim 37, wherein thickening agent is the pyrogenic silica that the concentration with maximum about 5wt.% exists.

50. the hand cleaner in the claim 1 also contains the aromatic that adds with the concentration of maximum about 1.5wt.%.

51. the hand cleaner of claim 1 also contains one or more emollient that adds with the concentration of maximum about 5wt.%.

52. the hand cleaner of claim 51, wherein said emollient are to be selected from tea tree oil, cannabis oil, Aloe base oil and their combination.

53. the hand cleaner in the claim 37, the scope of described viscosity when temperature is 25 ℃ is to about 450cp from about 250cp.

54. the hand cleaner in the claim 37, wherein said antimicrobial are selected from two cresol phenol between chlorine, chlorhexidine gluconate, triclosan, quaternary ammonium salt and their combination.

55. the hand cleaner of claim 37, wherein said antimicrobial are the parachlorometaxylenols that adds to the concentration of about 3.75wt.% with about 2wt.%.

56. the hand cleaner of claim 37, wherein said alcohols is with the concentration of about 74wt.% to about 77wt.%, siloxy group material wherein is with the concentration of about 14wt.% to about 17wt.%, and antimicrobial is to exist respectively to the concentration of about 3.75wt.% with about 1wt.%.

57. the hand cleaner of claim 1 also comprises this product is added to surgical operation with on the ecouvillon.

58. the hand cleaner of claim 37 also comprises this product is added to surgical operation with on the ecouvillon.

59. the hand cleaner of claim 1 also comprises this cleaning agent is added on the handkerchief.

60. the hand cleaner of claim 37 also comprises this cleaning agent is added on the handkerchief.