CN1469926A - Compositions and methods for the therapy and diagnosis of lung cancer - Google Patents

Abstract

Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

Description

The composition and the method for treatment and diagnosing

The invention technical field

The present invention generally relates to the treatment and the diagnosis of cancer such as lung cancer.The present invention relates more specifically to comprise the polypeptide of at least a portion lung tumor protein, and the polynucleotide of this peptide species of encoding.This peptide species and polynucleotide can be used in diagnosis and treatment lung cancer drugs composition such as vaccine and other composition.Background of invention

Lung cancer is the major cause of U.S.'s masculinity and femininity cancer mortality, reports in 1994 and to estimate 172,000 new cases.Disease stadium when not considering to diagnose, the five-year survival rate of all patients with lung cancer only are 13%.This and disease still are limited in the case that local time just found 46% five-year survival rate and form contrast.Yet, only have 16% lung cancer before disease is sent out, to be found.

The early detection difficulty because usually can't see clinical symptom, has reached the progress stage until disease.At present, use chest x-ray, type and the bronchofiberscopy of analyzing contained cell in the phlegm come auxiliary diagnosis.Treatment plan is by the type of cancer and decide by stages, comprises operation, radiotherapy and/or chemotherapy.Although treatment of diseases has been carried out big quantity research, lung cancer still is difficult to treatment.

Therefore, this area still needs to be used for improvement vaccine, methods of treatment and the diagnostic techniques of lung cancer.Summary of the invention

On the one hand, the invention provides the polynucleotide compositions that comprises the sequence that is selected from down group:

(a) SEQ ID NO:217-390,392,394,396,398-420,422-424, the sequence that 428-433 and 440-583 provide;

(b) SEQ ID NO:217-390,392,394,396,398-420,422-424, the complement of the sequence that 428-433 and 440-583 provide;

(c) by SEQ ID N0:217-390,392,394,396,398-420,422-424, at least 20 sequences that continuous residue is formed in the sequence that 428-433 and 440-583 provide;

(d) under medium stringent condition, with SEQ ID NO:217-390,392,394,396,398-420,422-424, the sequence of the sequence hybridization that 428-433 and 440-583 provide;

(e) with SEQ ID NO:217-390,392,394,396,398-420,422-424, the sequence of 428-433 and 440-583 has the sequence of at least 75% identity;

(f) with SEQ ID NO:217-390,392,394,396,398-420,422-424, the sequence of 428-433 and 440-583 has the sequence of at least 90% identity: and

(g) SEQ ID NO:217-390,392,394,396,398-420,422-424, the degeneracy varient of the sequence that 428-433 and 440-583 provide.

In a preferred embodiment, survey in the lung tumor sample about at least 20%, more preferably about at least 30%, most preferably about at least 50% expresses polynucleotide compositions of the present invention, about at least 2 times of its levels than healthy tissues height, preferably about at least 5 times, most preferably about at least 10 times.

The present invention provides the peptide composition that comprises by the aminoacid sequence of above-mentioned polynucleotide sequence coding in yet another aspect.

In specific embodiments, the invention provides to comprise and be selected from SEQ ID NO:391,393,395,397,421,425-427, the peptide composition of the aminoacid sequence of sequence shown in 434-439 and the 584-587.

In some preferred embodiment, polypeptide of the present invention and/or polynucleotide have immunogenicity, and promptly they can cause immunne response, particularly body fluid and/or cellullar immunologic response, as further described herein.

The present invention further provides the fragment of disclosed polypeptide and/or polynucleotide sequence, varient and/or derivative, fragment wherein, preferred its immunogen activity level of varient and/or derivative is SEQ ID NOs:391,393,395,397,421,425-427, peptide sequence shown in 434-439 and the 584-587 or by SEQ ID NOs:217-390,392,394,396,398-420,422-424, the immunogen activity level of the peptide sequence of polynucleotide sequence coding shown in 428-433 and the 440-583 about at least 50%, preferably about at least 70% and more preferably about at least 90%.

The present invention further provides the coding aforementioned polypeptides polynucleotide, comprise the expression vector of this polynucleotide and with the host cell of this expression vector conversion or transfection.

In others, the invention provides and comprise that aforesaid polypeptide or polynucleotide and physiology can accept the pharmaceutical composition of carrier.

In the related fields of the present invention, provide pharmaceutical composition such as vaccine composition to be used for prevention or treatment application.This composition generally includes immunogenic polypeptide of the present invention or polynucleotide and immunostimulant, as adjuvant.

The present invention further provides pharmaceutical composition, having comprised: (a) with polypeptid specificity bonded antibody of the present invention or its Fab, or its fragment; (b) physiology can be accepted carrier.

In others, the invention provides pharmaceutical composition, comprising: (a) antigen presenting cell of expression aforementioned polypeptides and (b) pharmaceutical acceptable carrier or vehicle.The antigen presenting cell of example comprises dendritic cell, scavenger cell, monocyte, inoblast and B cell.

In related aspect, pharmaceutical composition is provided, comprising: (a) antigen presenting cell of expression aforementioned polypeptides and (b) immunostimulant.

In others, the present invention further provides the fusion rotein that comprises at least a aforementioned polypeptides, and the polynucleotide of this fusion rotein of encoding, typically with the form of pharmaceutical composition, as vaccine composition, comprise that physiology can accept carrier and/or immunostimulant.Fusion rotein can comprise a plurality of immunogenic polypeptides or its part/varient, as described here, and may further include one or more expression of polypeptides, purifying and/or immunogenic polypeptide fragments of being beneficial to.

Further, the invention provides stimulates patient's immunne response, and the method for preferred human patients t cell response comprises giving pharmaceutical composition described here.The patient can suffer from lung cancer, and in this case, this method is used for the treatment of disease, or can prophylactically treat the patient who is considered to have this disease risks of trouble.

In others, the invention provides the method that suppresses patient's cancer development, comprise to the patient and use aforementioned pharmaceutical compositions.Described patient can suffer from lung cancer, and this moment, this method was used for the treatment of disease, or is considered to have the patient who suffers from this sick risk and can carries out prophylactic treatment.

In others, the present invention further provides the method for from biological specimen, removing tumour cell, comprise the T cell that makes biological specimen contact and polypeptid specificity reaction of the present invention, wherein contact procedure is implemented the sufficiently long time being enough to allow to remove under the condition of expressing described proteic cell from sample.

In related fields, the method that suppresses patient's cancer development is provided, comprise to the patient and use the biological specimen of handling as mentioned above.

In others, further providing stimulates and/or expands method to the T cell of polypeptid specificity of the present invention, comprises making the following one or more materials of T cells contacting: (i) above-mentioned polypeptide; (ii) the encode polynucleotide of this peptide species; And/or (iii) express the antigen presenting cell of this peptide species; The condition of contact and time are enough to allow to stimulate and/or expand the T cell.Also provide and comprised the isolating T cell mass of the T cell of preparation as mentioned above.

Further, the invention provides the method that suppresses patient's cancer development, comprise the above-mentioned T cell mass of using significant quantity to the patient.

The present invention further provides the method that suppresses patient's cancer development, may further comprise the steps: (a) will be from the isolating CD4+ of patient and/or CD8+T cell and following one or more material co-cultivation: the immunogenicity polypeptide partly that (i) comprises polypeptide disclosed herein at least; (ii) the encode polynucleotide of this peptide species; (iii) express the antigen presenting cell of this peptide species; (b) use the proliferative T cell of significant quantity to the patient, thereby suppress the progress of patient's cancer.Proliferative cell can but need before giving the patient, to clone.

Further, the invention provides and determine that there is or does not exist cancer in the patient, the method for preferred lung cancer comprises that (a) makes biological specimen contact that obtains and the polypeptide bonded wedding agent of as above enumerating from the patient; (b) detect in the sample amount with wedding agent bonded polypeptide; (c) compare the amount and the pre-cutoff value of determining of polypeptide, thereby determine patient's existence or do not have cancer.In preferred embodiments, wedding agent is an antibody, more preferably monoclonal antibody.

In others, the present invention also provides the method for monitoring patient cancer progression.This method may further comprise the steps: the biological specimen that obtains from the patient is contacted and the polypeptide bonded wedding agent of as above enumerating at very first time point; (b) detect in the sample amount with wedding agent bonded polypeptide; (c) use the biological specimen that obtains from the patient to put repeating step (a) and (b) in later time; (d) amount that detects in polypeptide amount that detects in the comparison step (c) and the step (b), thereby the progress of monitoring patient cancer.

In others, the present invention further provides definite patient and existed or do not have method for cancer, may further comprise the steps: the oligonucleotide that (a) makes the biological specimen contact that obtains from the patient and the multi-nucleotide hybrid of code book invention polypeptide; (b) detect in the sample level with the preferred mRNA of polynucleotide of oligonucleotide hybridization; (c) compare and the polynucleotide level of oligonucleotide hybridization and the cutoff value of determining in advance, thereby determine patient's existence or do not have cancer.In certain embodiments, for example use the Oligonucleolide primers of the complement hybridization of the polynucleotide of at least one polypeptide of as above enumerating with coding or this polynucleotide, detect the amount of mRNA by the polymerase chain reaction.In other embodiments, the oligonucleotide probe of the complement hybridization of the polynucleotide of the polypeptide that utilization and coding are as above enumerated or this polynucleotide, the amount of use hybridization technique detection mRNA.

In related fields, the monitoring patient is provided the method for cancer progression, may further comprise the steps: the oligonucleotide that (a) makes the biological specimen contact that obtains from the patient and the multi-nucleotide hybrid of code book invention polypeptide; (b) detect in the sample amount with the polynucleotide of oligonucleotide hybridization; (c) be used in biological specimen repeating step (a) that time point afterwards obtains from the patient and (b); (d) amount that detects in polynucleotide amount that detects in the comparison step (c) and the step (b), thereby the progress of monitoring patient cancer.

Further, the invention provides and above-mentioned polypeptide bonded antibody, for example monoclonal antibody, and the diagnostic kit that comprises this antibody.The diagnostic kit that comprises one or more above-mentioned oligonucleotide probes or primer also is provided.

With reference to following detailed description, these and other aspect of the present invention will become obvious.All reference disclosed herein are incorporated herein by reference with its integral body, as every piece of quilt is introduced separately.Detailed Description Of The Invention

The present invention generally relate to composition and cancer particularly lung cancer treatment and the diagnosis in application.Following further description, exemplified composition of the present invention includes but not limited to polypeptide, immunogenic polypeptide particularly, the polynucleotide of this peptide species of encoding, antibody and other wedding agent, antigen presenting cell (APCs) and immune system cell (as the T cell).

Unless reverse special instructions are arranged, practice of the present invention will be adopted the ordinary method of virusology, immunology, microbiology, molecular biology and recombinant DNA technology in the art technology, wherein manyly be described as example below.This technology has complete explanation in the literature.Referring to for example Sambrook etc., Molecular Cloning:A Laboratory Manual (second edition, 1989); Maniatis etc., Molecular Cloning:ALaboratory Manual (1982); DNA Cloning:A PracticalApproach, vol.I ﹠amp; II (D.Glover chief editor); OligonucleotideSynthesis (N.Gait chief editor, 1984); Nucleic Acid Hybridization (B.Hames ﹠amp; The S.Higgins chief editor, 1985); Transcription andTranslation (B.Hames ﹠amp; The S.Higgins chief editor, 1984); Animal CellCulture (R.Freshney chief editor, 1986); Perbal, A Practical Guideto Molecular Cloning (1984).

All publications, patent and the patent application of quoting here, no matter aforementioned or aftermentioned all is incorporated herein by reference with its complete form at this.

As the use in this specification sheets and the claims, " one (individual) " and " this (individual) " of singulative comprise plural reference, point out not to be like this unless content is clear. Peptide composition

Term used herein " polypeptide " uses its conventional meaning, promptly as the amino acid of a sequence.Polypeptide is not limited to the product of length-specific; Therefore, peptide, oligopeptides and albumen all are included in the definition of polypeptide, and this term can exchange use here, unless specialize.This term also do not refer to or get rid of polypeptide expression after modify, for example, glycosylation, acetylize, phosphorylation or the like, and other modification known in the art comprise spontaneous generation and non-abiogenous.Polypeptide can be intact proteins or its subsequence.Interested especially polypeptide is to comprise the aminoacid sequence that epi-position is an antigenic determinant in the content of the present invention, and described epi-position produces the immunogen characteristic of polypeptide in fact and can excite immunne response.

The polypeptide of the special example of the present invention comprises that those are by SEQ ID NO:217-390,392,394,396,398-420,422-424, the polypeptide of the polynucleotide sequence coding shown in any one among 428-433 and the 440-583, or under the medium stringent condition or alternatively under the height stringent condition, with SEQ ID NOs:217-390,392,394,396,398-420,422-424, the sequence encoded polypeptide of the polynucleotide sequence hybridization among 428-433 and the 440-583 shown in any one.Some other example polypeptide of the present invention comprises the NO:391 as SEQID, 393,395,397,421, and 425-427, the aminoacid sequence shown in any one among 434-439 and the 584-587.

Polypeptide of the present invention is meant lung tumor protein or lung tumor polypeptide sometimes here, represents that identifying to small part of they increases based on its expression level in the lung tumor sample.Therefore, " lung tumor polypeptide " or lung tumor protein " generally be meant peptide sequence of the present invention; or the polynucleotide sequence of this peptide species of encoding; they are expressed in quite most lung tumor sample, it is about 20% for example to account for preferably being higher than of the lung tumor sample that detected, more preferably is approximately higher than 30% greatly; most preferably be higher than about 50% or more; its level is than normal tissue expression level high twice at least, preferably at least five times, such as adopt the representative test that provides here mensuration.Lung tumor polypeptide sequence of the present invention, particularly useful in as diagnostic flag and treatment target based on the increase of its expression level in tumour cell, following further describing.

In some preferred embodiment, polypeptide of the present invention is immunogenic, promptly they can detect in immunoassay (as the test of ELISA or T cytositimulation) react with antiserum(antisera) and/or T cell from patients with lung cancer.Can use the immunogenic screening of technology implementation well known to those skilled in the art.For example, can use as Harlow and Lane, Antibodies:A Labora-tory Manual, Cold Spring HarborLaboratory, the method for describing in 1988 is carried out this screening.In the embodiment of an example, polypeptide can be fixed on the solid support and contact the patients serum and combine with the fixed polypeptide to allow the antibody in the serum.For example can remove unconjugated serum and use then ¹²⁵The albumin A of I mark detects bonded antibody.

As the skilled person will recognize, the immunogenicity of polypeptide disclosed herein partly is also contained among the present invention.Here used " immunogenicity part " is the fragment of immunogenic polypeptide of the present invention, itself can with identification polypeptide B cell and/or t cell surface antigen acceptor generation immunological response (being that specificity combines).Immunogenicity part can be used usually and know technology and identify, Paul for example, and Fundamental Immunology, 3rd ed., 243-247 (Raven Press, 1993) and the reference of quoting are here summed up.This technology comprises the ability of screening polypeptide and antigen-specific antibodies, antiserum(antisera) and/or T clone or cloning reaction.If antiserum(antisera) used herein and antibody they combine with antigen-specific (be they in ELISA or other immunoassay with albumen test, and nothing to do with albumen takes place and can detectedly react), then be antigen-specific ".

In a preferred embodiment, the immunogenicity of polypeptide of the present invention partly is the part that reacts with the level of the reactivity (as in ELISA and/or t cell responses mensuration) that is not less than full-length polypeptide substantially with antiserum(antisera) and/or T cell.Preferably, the immunogenicity level of immunogenicity part is that full-length polypeptide is immunogenic about at least 50%, preferably about at least 70% and most preferably greater than about 90%.In some cases, the immunogenicity level that the preferred immunogenicity of being identified partly has is higher than corresponding full-length polypeptide, as has and be higher than about 100% or 150% or higher immunogenicity.

In some other embodiment, the immunogenicity of example part can comprise the peptide that has lacked N-terminal leader sequence and/or membrane spaning domain.The immunogenicity part of other example will contain little N and/or C-terminal disappearance (as 1-30 amino acid, preferred 5-15 amino acid) with respect to maturation protein.

In another embodiment, peptide composition of the present invention can also comprise one or more and the T cell that produces at polypeptide of the present invention and/or the polypeptide of antibody generation immunological response, the polypeptide that particularly has aminoacid sequence disclosed herein, or its immunogenic fragments or varient.

In another embodiment of the invention, the polypeptide that provides comprises one or more can be caused and the T cell of one or more polypeptide generation immunological responses described herein and/or the polypeptide of antibody, or one or more are by the continuous kernel acid sequence that comprises in the polynucleotide sequence disclosed herein, or its immunogenic fragments or varient, or one or more with these sequences in medium one or more nucleotide sequence encoded polypeptide of hybridizing under the stringent condition to height.

In yet another aspect, the invention provides polypeptide fragment, comprise the peptide composition of enumerating here, SEQ ID NO:391 for example, 393,395,397,421,425-427, the those polypeptides that 434-439 and 584-587 enumerate or by SEQ ID NO:217-390,392,394,396,398-420,422-424 is in the those polypeptides of the polynucleotide sequence coding of enumerating in the sequence of 428-433 and 440-583 about at least 5,10,15,20,25,50 or 100 continuous amino acids, or more, comprise all intermediate lengths.

In yet another aspect, the invention provides the varient of peptide composition described herein.The polypeptide variants that the present invention generally includes typically demonstrates with the peptide sequence of enumerating here has about at least 70%, 75%, 80%, 85%, 90% along its length, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% or higher identity (following determine).

In a preferred embodiment, polypeptide fragment provided by the invention and varient and with the antibody and/or the T cell generation immunological response of the full-length polypeptide enumerated especially here reaction.

In a further preferred embodiment, the immunogenicity level that polypeptide fragment provided by the invention and varient demonstrate be the full-length polypeptide sequence enumerated especially here shown go out immunogenic about at least 50%, preferably about at least 70%, most preferably about at least 90% or higher.

Term polypeptide used herein " varient " is that the typical case is different from the polypeptide of disclosed especially polypeptide here by one or more displacements, disappearance, interpolation and/or insertion.This varient can spontaneous generation maybe can synthesize generation, for example the peptide sequence by modifying one or more the invention described above and as described here and/or use any its immunogenicity of estimating in a large amount of technology well known in the art.

For example, some example varient of polypeptide of the present invention comprises has removed one or more parts, as those of N-terminal leader sequence or membrane spaning domain.Other example varient comprises that wherein sub-fraction (as 1-30 amino acid, preferred 5-15 amino acid) is from those of the N of maturation protein and/or C-terminal removal.

Under many circumstances, varient contains conservative substitution." conservative substitution " is another amino-acid substitution that amino acid is had similar performance, makes the technician in chemistry of peptides field estimate that the secondary structure of this polypeptide and wetting ability do not change substantially.As mentioned above, can in polynucleotide of the present invention and polypeptide structure, modify, and still obtain a coding and have the varient of desired characteristic such as immunogen characteristic or the functional molecular of the polypeptide of deriving.When expectation changes amino acid sequence of polypeptide and produces equivalent, or even when the improved immunogenicity varient of polypeptide of the present invention or part, those skilled in the art can change one or more codons of dna encoding sequence usually according to table 1.

For example, some amino acid can be by other amino-acid substitution in the protein structure, and not obvious forfeiture with as the antigen binding domain of antibody or the structural interaction bonded ability the binding site on the substrate molecule.Owing to be that proteic interaction ability and character define proteic biological function activity, can carry out some aminoacid sequence displacement to the dna encoding sequence on protein sequence and basis thereof, and obtain the albumen of similar performance.Therefore expection can be in the peptide sequence of disclosed composition, or carries out various changes in the dna sequence dna of the described peptide of respective coding, and not obvious forfeiture its biological practicality or activity.Table 1

Amino acid			Codon
				L-Ala	Ala	A	GCA?GCC?GCG?GCU
Halfcystine	Cys	C	UGC?UGU
				Aspartic acid	Asp	D	GAC?GAU
L-glutamic acid	Glu	E	GAA?GAG
				Phenylalanine	Phe	F	UUC?UUU
Glycine	Gly	G	GGA?GGC?GGG?GGU
				Histidine	His	H	CAC?CAU
Isoleucine	Ile	I	AUA?AUC?AUU
				Methionin	Lys	K	AAA?AAG
Leucine	Leu	L	UUA?UUG?CUA?CUC??CUG CUU
				Methionine(Met)	Met	M	AUG
L-asparagine	Asn	N	AAC?AAU
				Proline(Pro)	Pro	P	CCA?CCC?CCG?CCU
Glutamine	Gln	Q	CAA?CAG
				Arginine	Arg	R	AGA??AGG??CGA??CGC??CGG CGU
Serine	Ser	S	AGC?AGU?UCA?UCC?UCG UCU
				Threonine	Thr	T	ACA?ACC?ACG?ACU
Xie Ansuan	Val	V	GUA?GUC?GUG?GUU
				Tryptophane	Trp	W	UGG
Tyrosine	Tyr	Y	UAC?UAU

When carrying out this change, hydrophilic index that can considered amino acid.The hydrophilic amino acid exponential importance of giving the protein interaction biological function be this area usually known to (Kyte and Doolittle, 1982, be incorporated herein by reference here).Accepted amino acid whose relative water-wet behavior and helped the proteic secondary structure of gained, it limits the interaction of albumen and other molecule such as enzyme, substrate, acceptor, DNA, antibody, antigen or the like successively.Based on its hydrophobicity and charge characteristic, each amino acid has been specified hydrophilic index (Kyte and Doolittle, 1982) respectively.These values are: Isoleucine (+4.5); Xie Ansuan (+4.2); Leucine (+3.8); Phenylalanine (+2.8); Halfcystine/Gelucystine (+2.5); Methionine(Met) (+1.9); L-Ala (+1.8); Glycine (0.4); Threonine (0.7); Serine (0.8); Tryptophane (0.9); Tyrosine (1.3); Proline(Pro) (1.6); Histidine (3.2); L-glutamic acid (3.5); Glutamine (3.5); Aspartic acid (3.5); L-asparagine (3.5); Methionin (3.9) and arginine (4.5).

Some amino acid known in the art can also still be produced by other amino-acid substitution with similar hydrophilic index or score value has similar bioactive albumen, promptly still obtains the albumen that biological function is equal to.When carrying out this change, preferred hydrophilic index is ± 2 with interior amino acid whose displacement, and preferred ± 1 is with interior especially, even more preferably ± 0.5 with interior amino acid.This area is also understood based on wetting ability can effectively carry out similar amino acid whose displacement.United States Patent (USP) 4,554,101 (being incorporated herein by reference especially with its complete form here), statement is relevant with proteic biological property by the maximum local average wetting ability of albumen of the wetting ability control of its adjacent amino acid.

United States Patent (USP) 4,554,101 describe amino-acid residue in detail has following hydrophilicity value: arginine (+3.0); Methionin (+3.0); Aspartic acid (+3.0 ± 1); L-glutamic acid (+3.0 ± 1); Serine (+0.3); L-asparagine (+0.2); Glutamine (+0.2); Glycine (0); Threonine (0.4); Proline(Pro) (0.5 ± 1); L-Ala (0.5); Histidine (0.5); Halfcystine (1.0); Methionine(Met) (1.3); Xie Ansuan (1.5); Leucine (1.8); Isoleucine (1.8); Tyrosine (2.3); Phenylalanine (2.5); Tryptophane (3.4).Understood amino acid and can be replaced into another amino acid with similar hydrophilicity value and still obtain biochemical equivalents, particularly immunology is equal to albumen.In this change, the preferred hydrophilic value is ± 2 with interior amino acid whose displacement, and preferred ± 1 is with interior especially, even more preferably ± 0.5 with interior amino acid.

Therefore as top generalized, amino-acid substitution is usually based on the substituent relative similarity of amino acid side chain, for example, and their hydrophobicity, wetting ability, electric charge, size or the like.The demonstration displacement of considering various afore-mentioned characteristics is well known to those skilled in the art and comprises: arginine and Methionin; L-glutamic acid and aspartic acid; Serine and Threonine; Glutamine and l-asparagine; With Xie Ansuan, leucine and Isoleucine.

In addition, can further modify any polynucleotide and be increased in intravital stability.Possible modification includes but not limited at 5 ' and/or 3 ' the terminal flanking sequence that adds; In skeleton, use thiophosphoric acid or 2 ' O-methyl, rather than phosphodiesterase connects; And/or be mingled with unconventional base for example inosine, queosine and wybutosine, and the VITAMIN B4 of ethanoyl, methyl, sulfo-and other modified forms, cytidine, guanine, thymus pyrimidine and uridine.

Can carry out amino-acid substitution based on polarity, electric charge, solubleness, hydrophobicity, wetting ability and/or the amphipathic similarity of residue.For example, electronegative amino acid comprises aspartic acid and L-glutamic acid; Positively charged amino acid comprises Methionin and arginine; Comprise leucine, Isoleucine and Xie Ansuan with the amino acid that has the neutral polar head-group with similar hydrophilicity value; Glycine and L-Ala; L-asparagine and glutamine; With Serine, Threonine, phenylalanine and tyrosine.Can represent conservative other amino acid group that changes to comprise: (1) ala, pro, gly, glu, asp, gln, asn, ser, thr; (2) cys, ser, tyr, thr; (3) val, ile, leu, met, ala, phe; (4) lys, arg, his; (5) phe, tyr, trp, his.Varient also can or selectively contain non-conservative change.In preferred embodiments, the variation polypeptide is different from native sequences owing to five or still less amino acid whose displacement, disappearance or interpolation.Varient also can (or available) be modified, and for example by disappearance or interpolation immunogenicity, secondary structure and the wetting ability of polypeptide is influenced the amino acid of minimum.

As noted above, polypeptide can be included in signal (or leading) sequence of proteic N-terminal, and it is when common translation or instruct albumen to shift after translation.Polypeptide also can combine with joint or other sequence, with synthetic, the purifying that is easy to polypeptide or evaluation (as poly--His), or strengthen combining of polypeptide and solid support.For example, polypeptide can binding domain-immunoglobulin Fc district.

When many peptide sequences,, then claim two sequences " to be equal to " if as described belowly compare that to make maximum aminoacid sequence to seasonable two sequences be identical.Between two sequences more typically by comparative sequences in the contrast window with identify and relatively the sequence similarity of regional area carry out." contrast window " used herein is meant the fragment in about at least 20 continuous sites, and common 30 to about 75,40 to about 50, and wherein with after the best comparison of two sequences, sequence can compare with the reference sequences in the continuous site of similar number.

The best of sequence comparison is compared the Megalign program that can use bioinformation software Lasergene package, and (Madison WI) carries out for DNASTAR, Inc., uses default parameters.This program comprises several comparison schemes, in following reference, describe: Dayhoff, M.O. (1978) A model of evolutionary change in proteins-Matrices for detecting distant relationships.In Dayhoff, M.O. (ed.) Atlas of Protein Sequence and Structure, NationalBiomedical Research Foundation, Washington DC Vol.5, Suppl.3, pp.345-358; Hein J. (1990) Unified Approach toAlignment and Phylogenes 626-645 page or leaf Methods in Enzymology183 volume, Academic Press, Inc., San Diego, CA; Higgins, D.G. and Sharp, P.M. (1989) CABIOS 5:151-153; Myers, E.W. and Muller W. (1988), CABIOS 4:11-17; Robinson, E.D. (1971) Comb.Theor 11:105; Santou, N.Nes, M. (1987) Mol.Biol.Evol.4:406-425; Sneath, P.H.A. and Sokal, R.R. (1973) Numerical Taxonomy-the Principles and Practice ofNuyrierical Taxonomy, Freeman Press, San Francisco, CA; Wilbur, W.J. and Lipman, D.J. (1983) Proc.Natl.Acad., Sci.USA 80:726-730.

Alternatively, implementation sequence the best comparison relatively can be by the local identity algorithm of Smith and Waterman (1981) Add.APL.Math 2:482, the identity alignment algorithm of Needleman and Wunsch (1970) J Mol.Biol.48:443, the retrieval similarity method of Pearson and Lipman (1988) Proc.Natl.Acad.Sci.USA85:2444, (the GAP in the Wisconsin-genetics software package is implemented in the computerize of these algorithms, BESTFIT, BLAST, FASTA, and TFASTA, Genetics Computer Group (GCG), 575 Science Dr., Madison, WI), or by inspecting.

Optimization algorithm example that be fit to determine sequence identity and sequence similarity per-cent is BLAST and BLAST 2.0 algorithms, describes in (1990) J.Mol.215:403-410 such as (1977) Nucl.AcidsRes.25:3389-3402 such as Altschul and Altschul respectively.Can use BLAST and BLAST 2.0, for example use parameter described herein, to determine the sequence identity per-cent of polynucleotide of the present invention and polypeptide.The software that carries out the BLAST analysis can obtain by the National Center for Biotechnology Information public.For aminoacid sequence, can use score matrix computations accumulated value.When: accumulation comparison value is from its maximum value of obtaining decline quantity X; Since the accumulation of one or more negative score value residues comparisons, accumulated value reach zero or below; Or when arriving in two sequences any one end, the extension that word hits on each direction stops.BLAST algorithm parameter W, the susceptibility and the speed of T and X decision comparison.

In a preferred method, " sequence identity per-cent " is decided by the sequences that compare two best comparisons at least in the contrast window in 20 sites, the peptide sequence part that wherein contrasts in the window is compared with the reference sequences (do not comprise and add or disappearance) of the best comparison of two sequences, can comprise percent 20 or interpolation still less or disappearance (being breach), common percent 5 to 15, or percent 10 to 12.The calculating of per-cent is counted to obtain match bit by determining the number of sites that occurs the same amino acid residue in two sequences, and match bit is counted divided by the site sum of reference sequences (being window size), and the result multiply by 100 and obtains sequence identity per-cent.

In other example embodiment, polypeptide can be a fusion polypeptide, and it comprises multiple polypeptides described here, or comprises at least a polypeptide described here and a kind of irrelevant sequence, for example known oncoprotein.Fusion partner can for example assist to provide T to assist epi-position (immunology fusion partner), and the auxiliary epi-position of the T of preferred people's identification maybe can assist albumen to express (expression enhanser) with the output higher than natural recombinant protein.Some preferred fusion partner is immunology simultaneously and expresses the enhancing fusion partner.Can select other fusion partner with the solubleness that increases polypeptide or make polypeptide be oriented to the intracellular region chamber of expectation.The fusion rotein mating partner also comprises affinity labelling, and it helps the purifying of polypeptide.

Usually can adopt standard technique to prepare fusion rotein, comprise Chemical bond.Preferred fusion polypeptide is expressed as recombinant polypeptide, makes that the product level increases to some extent with respect to non-fusion polypeptide in the expression system.In brief, can separately assemble the dna sequence dna of coded polypeptide composition, and be connected in the suitable expression.With the dna sequence dna 3 ' end of a polypeptide composition of coding, with or without peptide linker, be connected with the dna sequence dna 5 ' end of second polypeptide composition of coding, make the reading frame homophase of calling sequence.This allows to be translated as the bioactive single fusion polypeptide that keeps two composition polypeptide.

Can use the peptide linker sequence to be folded into separating distance first and second polypeptide composition of its secondary and tertiary structure with each peptide of sufficient to guarantee.Use standard technique well known in the art that this peptide linker sequence is introduced fusion polypeptide.Suitable peptide linker sequence can be selected based on following factors: it adopts the ability of extending conformation flexibly (1); (2) its do not adopt with first and second polypeptide on the ability of the interactional secondary structure of functional epitope; (3) lack may with the hydrophobicity or the charged residue of polypeptide functional epitope reaction.Preferred peptide linker sequence comprises Gly, Asn and Ser residue.Other nearly neutral amino acids, for example Thr and Ala also can be used for joint sequence.Can be effectively comprise those at Maratea etc. as the aminoacid sequence of joint, Gene 40:39-46,1985; Murphy etc., Proc.Natl.Acad.Sci.USA 83:8258-8262,1986; United States Patent (USP) 4,935,233 and United States Patent (USP) 4,751,180 in disclosed sequence.Joint sequence length usually can be from 1 to about 50 amino acid.When first and second polypeptide have the nonessential N-terminal amino acid district that can be used for the separation function territory and prevent spatial interference, do not need joint sequence.

The bonded dna sequence dna can be operatively connected suitable transcribing or the translational control element.The controlling element of being responsible for the DNA expression only is positioned at 5 ' end of the dna sequence dna of first polypeptide of coding.Similarly, stopping required terminator codon of translation and transcription termination signal also only brings out existing at 3 ' of the dna sequence dna of second polypeptide of coding.

Fusion polypeptide can comprise polypeptide described here and irrelevant immunogenic protein, for example can cause the immunogenic protein of memory response.This proteic example comprises tetanus, pulmonary tuberculosis and hepatitis albumen (referring to as Stoute etc., New Engl.J.Med., 336:86-91,1997).

In a preferred embodiment, the Immune Fusion mating partner is from Mycobacterium, for example from the Ra12 fragment of mycobacterium tuberculosis.Ra12 composition and describe in U.S. Patent application 60/158,585 in the expression and/or the using method in the immunogenicity that strengthen heterologous polynucleotide/peptide sequence, its content is incorporated herein by reference document with complete form here.In brief, Ra12 is meant the polynucleotide district of the subsequence of mycobacterium tuberculosis MTB32A nucleic acid.MTB32A is the serine protease of molecular weight 32KD of the genes encoding of mycobacterium tuberculosis virulent strain and avirulent strain.MTB32A nucleotide sequence and aminoacid sequence are open, and (for example, U.S. Patent application 60/158,585; Also see, Skeiky etc., Infectionand Immun. (1999) 67:3998-4007 is hereby incorporated by document).The C-terminal fragment of MTB32A encoding sequence remains soluble polypeptide with high level expression and in whole purge process.And Ra12 can strengthen the immunogenicity with the alloimmunization originality polypeptide of its fusion.A preferred Ra12 fusion polypeptide comprises the 14kD C-terminal fragment of the amino-acid residue 192 to 323 of corresponding MTB32A.Other preferred Ra12 polynucleotide generally include about at least 15 successive Nucleotide of a coding Ra12 polypeptide part, at least about 30 Nucleotide, about at least 60 Nucleotide, about at least 100 Nucleotide, at least about 200 Nucleotide, or about at least 300 Nucleotide.The Ra12 polynucleotide can comprise that native sequences (promptly encode Ra12 polypeptide or its a part of endogenous sequence) maybe can comprise the varient of this sequence.Ra12 polynucleotide varient can comprise one or more displacements, interpolation, disappearance and/or insertion, and the biological activity of the fusion polypeptide of feasible coding does not reduce basically with respect to the fusion polypeptide that contains natural Ra12 polypeptide.Preferred varient demonstrate and the encode identity of natural Ra12 polypeptide or its a part of polynucleotide sequence about at least 70%, more preferably about at least 80% identity and most preferably about at least 90% identity.

In other embodiment preferred, the Immune Fusion mating partner is from the surface protein (WO 91/18926) of protein D-gram negative bacterium hemophilus influenzae B.Preferably, the protein D derivative comprise approximately this proteic first three/one (as a most preceding N-terminal 100-110 amino acid), and the protein D derivative can fatization.In certain preferred aspects, the most preceding 109 residues of lipoprotein D fusion partner are included in N-terminal, for polypeptide provides other external source t cell epitope and the expression level (therefore working to express enhanser) that is increased in the intestinal bacteria.The lipid afterbody guarantees that antigen presents to the best of antigen presenting cell.Other fusion partner comprises the Nonstructural Protein from influenza virus, NS1 (hemagglutinin).Typically, use 81 amino acid of N-terminal, although can use the different fragments that comprises the auxiliary epi-position of T.

In another embodiment, the Immune Fusion mating partner is known protein LYTA, or its part (preferred C-terminal part).LYTA is from streptococcus pneumoniae, and it synthesizes and is called N-ethanoyl-L-ala amide enzyme of Ntn hydrolase LYTA (by the LytA genes encoding; Gene 43:265-292,1986).LYTA is the autolysin of some key in the specificity degraded peptidoglycan skeleton.The affinity with choline or some cholinomimetics such as DEAE is responsible in the terminal territory of LYTA PROTEIN C.This performance has been utilized the intestinal bacteria C-LYTA expression plasmid of exploitation effective expression fusion rotein.The purifying that contains the segmental hybrid protein of C-LYTA at N-terminal has had description (seeing Biotechnology 10:795-798,1992).In a preferred embodiment, the repeating part of LYTA can mix fusion polypeptide.Find that repeating part begins at C-terminal district residue 178 places.Particularly preferred repeating part mixes residue 188-305.

The embodiment of another example comprises fusion polypeptide and polynucleotides encoding them, and wherein fusion partner comprises and can instruct the targeting signal of polypeptide to endosome/lysosome compartment, as United States Patent (USP) 5,633, described in 234.Immune peptide of the present invention is when merging with this targeting signal, with the more efficient CD4 that also therefore strengthens polypeptid specificity that combines with MHC II quasi-molecule ⁺The body internal stimulus of T cell.

Use any various synthetic and/or recombinant technology of knowing to prepare polypeptide of the present invention, the latter under further describe.Usually can use the technology that those of ordinary skills know and produce with synthesizer less than about 150 amino acid whose polypeptide, its part and other varient.In the embodiment of an example, use the obtainable solid phase technique of any commerce to synthesize this peptide species, as the Merrifield solid phase synthesis process, wherein amino acid adds the amino acid chain of growth in proper order to.See Merrifield, J.Am.Chem.Soc.85:2149-2146,1963.The automatic synthesizer of polypeptide can be buied by commerce from supplier, and for example (Foster City CA), and can operate according to the directions for use of manufacturers PerkinElmer/Applied BioSystems Division.

Usually, peptide composition of the present invention (comprising fusion polypeptide) is isolating." isolating " polypeptide is told from its primal environment.For example, if in naturally occurring albumen or polypeptide and the natural system part or all coexisting substances separate be isolating.Preferred this peptide species can also be purified, as, about at least 90% is pure, and more preferably about at least 95% is pure and mild most preferably about at least 99% pure. Polynucleotide compositions

In others, the invention provides polynucleotide compositions.The term " DNA " and " polynucleotide " that use can exchange here basically, are meant the dna molecular of having separated from specific species total genomic dna." separation " used herein is meant basically and the isolating polynucleotide of other encoding sequence that this dna molecular does not conform to most irrelevant coding DNA, for example macrochromosome fragment or other functional gene or polypeptid coding area.Certainly, this is meant as original isolated DNA molecule, and does not get rid of the gene or the coding region of manually adding to afterwards on the fragment.

As skilled in the art will understand, polynucleotide compositions of the present invention can comprise genome sequence, and sequence that genome is outer and plasmid-encoded and expression maybe can be adapted to the littler modifying gene fragment of expressing protein, polypeptide, peptide or the like.This fragment can be natural isolating, or the synthetic modification.

To recognize also that as those skilled in the art polynucleotide of the present invention can be strands (coding or antisense) or double-stranded, and can be DNA (genome, cDNA or synthetic) or RNA molecule.The RNA molecule can comprise the HnRNA molecule, and it contains intron and corresponding one by one with dna molecular to mRNA molecule, and it does not contain intron.Coding in addition or non-coding sequence can, but be not essential, in polynucleotide of the present invention, occur, polynucleotide can, but be not essential, be connected with other molecule and/or support material.

Polynucleotide can comprise that native sequences (being code book invention polypeptide/albumen or its a part of endogenous sequence) maybe can comprise the sequence of coding varient or derivative, the immunogenicity varient or the derivative of preferred this sequence.

Therefore, according to another aspect of the present invention, the polynucleotide compositions that provides comprises part or all of following polynucleotide sequence: SEQ ID NO:217-390,392,394,396,398-420 422-424, any one cited polynucleotide sequence of 428-433 and 440-583, SEQ ID NO:217-390,392,394; 396,398-420 422-424, the complement of any one cited polynucleotide sequence of 428-433 and 440-583, SEQID NO:217-390,392,394,396,398-420 422-424, the degeneracy varient of any one cited polynucleotide sequence of 428-433 and 440-583.In certain preferred aspects, the polynucleotide sequence coding immunogenic polypeptide of enumerating here, as mentioned above.

In other related embodiment, the invention provides and have and SEQ IDNO:217-390 disclosed herein, 392,394,396,398-420 422-424,428-433 and 440-583 sequence have the polynucleotide varient of quite big identity, for example using method described herein to compare with polynucleotide sequence of the present invention (analyzes as using canonical parameter to carry out BLAST, as described below) comprise at least 70% sequence identity, preferably at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% or higher identity.Those skilled in the art will recognize that and consider codon degeneracy, amino acid similarity, reading frame location or the like, can suitably adjust these values to determine two nucleotide sequence coded proteic corresponding identity.

Typically, the polynucleotide varient will contain one or more displacements, interpolation, disappearance and/or insertion, preferably makes the immunogenicity of polypeptide of this varient polynucleotide encoding not reduce basically with respect to the polypeptide of the polynucleotide sequence coding of enumerating especially here.Term " varient " also is construed as the homologous gene that comprises the xenogenesis source.

In other embodiments, the invention provides polynucleotide passage, continuous one section sequence that it comprises being equal to of all lengths or is complementary to one or more sequences disclosed herein.For example, polynucleotide provided by the invention comprise in one or more sequences disclosed herein about at least 10,15,20,30,40,50,75,100,150,200,300,400,500 or 1000 or more continuous nucleotides and all intermediate lengths between them.Be readily appreciated that in this article, " intermediate length " is meant any length between the fiducial value, for example 16,17,18,19, etc.; 21,22,23, etc.; 30,31,32 etc.; 50,51,52,53 etc.; 100,101,102,103, etc., 150,151,152,153 etc.; Comprise 200-500; 500-1, all integers of 000 or the like.

In another embodiment of the invention, the polynucleotide compositions that provides can medium to the height stringent condition with the polynucleotide sequence or its fragment or its complementary sequence hybridization that provide here.Hybridization technique is that biology field is known.In order to illustrate, the suitable medium stringent condition that detects polynucleotide of the present invention and other multi-nucleotide hybrid is included in 5 * SSC, 0.5%SDS, prewashing in 1.0mM EDTA (pH8.0) solution; At 50 ℃-60 ℃, 5 * SSC hybridization is spent the night; Subsequently 65 ℃ of washed twice, 20 minutes, with respectively contain 2 of 0.1%SDS *, 0.5 * and 0.2 * SSC.The severity that it will be appreciated by those skilled in the art that hybridization can be easy to handle, and for example changes the salts contg of hybridization solution and/or the temperature of hybridizing.For example, in another embodiment, suitable height stringent hybridization condition comprises above-mentioned those, except hybridization temperature raise, for example arrive 60-65 ℃ or 65-70 ℃.

In certain preferred aspects, above-mentioned polynucleotide, for example polynucleotide varient, fragment and hybridization sequences, the polypeptide of coding and the peptide sequence generation immunological cross-reaction of enumerating especially here.In other embodiment preferred, the polypeptide of this polynucleotide encoding has about at least 50% of the peptide sequence enumerated especially here.Preferred about at least 70% and more preferably about at least 90% immunogenicity level.

Polynucleotide of the present invention or its fragment, no matter the length of encoding sequence itself, can combine with other dna sequence dna, for example promotor, polyadenylation signal, other restriction enzyme site, multiple clone site, other encode fragment or the like make that their whole length can noticeable change.Therefore expection can be used the almost nucleic acid fragment of any length, and total length preferably is used for limiting by the easy degree and the making in the recombinant DNA scheme of expectation of preparation.For example, total length about 10,000, about 5000, about 3000, about 2,000, about 1,000, about 500, about 200, about 100, the example polynucleotide passage expection of about 50 base pairs or the like (comprising all intermediate lengths) is to the numerous usefulness that implement of the present invention.

When many nucleotide sequences, if the nucleotide sequence in two sequences is identical during maximum corresponding comparison, then two sequences are called as " being equal to ", and are as described below.Between two sequences more typically by comparative sequences in the contrast window with identify and relatively the sequence similarity of regional area carry out." contrast window " used herein is meant the fragment in about at least 20 continuous sites, and common 30 to about 75,40 to about 50, and wherein after two sequence optimal arrangement, sequence can compare with the reference sequences in the continuous site of similar number.

The best comparison of sequence that is used for comparison can be used the Megalign program of bioinformation software Lasergene package, and (Madison WI) carries out for DNASTAR, Inc., uses default parameters.This program comprises several comparison schemes, in following reference, describe to some extent: Dayhoff, M.O. (1978) A model of evolutionary change inproteins-Matrices for detecting distant relationships.InDayhoff, M.O. (ed.) Atlas of Protein Sequence andStructure, National Biomedical Research Foundation, Washington DC Vol.5, Suppl.3, pp.345-358; Hein J. (1990) Unified Approach to Alignment and Phylogenes 626-645 page or leaf Methods in Enzymology 183 volumes, Academic Press, Inc., SanDiego, CA; Higgins, D.G. and Sharp, P.M. (1989) CABIOS 5:151-153; Myers, E.W. and Muller W. (1988) CABIOS 4:11-17; Robinson, E.D. (1971) Comb.Theor 11:105; Santou, N.Nes.M. (1987) Mol.Biol.Evol.4:406-425; Sneath, P.H.A and Sokal, R.R. (1973) Numerical Taxonomy-the Principles and Practice of NumericalTaxonomy, Freeman Press, San Francisco, CA; Wilbur, W.J. and Lipman, D.J. (1983) Proc.Natl.Acad., Sci.USA 80:726-730.

Alternatively, the enforcement that is used for the best comparison of sequence of comparison can be by the local identity algorithm of Smith and Waterman (1981) Add.APL.Math 2:482, the identity alignment algorithm of Needleman and Wunsch (1970) J Mol.Biol.48:443, the similarity retrieval method of Pearson and Lipman (1988) Proc.Natl.Acad.Sci.USA85:2444, (GAP in the Wisconsin-genetics software package is implemented in the computerize of these algorithms, BESTFIT, BLAST, FASTA, and TFASTA, Genetics Computer Group (GCG), 575 Science Dr., Madison is WI) or by inspecting.

A preferred example be fit to determining the algorithm of sequence identity and sequence similarity per-cent is BLAST and BLAST 2.0 algorithms, describes in (1990) J.Mol.Biol.215:403-410 such as (1977) Nucal.Acids Res.25:3389-3402 such as Altschul and Altschul respectively.Can use BLAST and BLAST 2.0, for example use parameter described herein, to determine the sequence identity per-cent of polynucleotide of the present invention.The software that carries out the BLAST analysis can obtain by the National Center for BiotechnologyInformation public.In an example embodiment, for nucleotide sequence, can operation parameter M (the reward score value of a pair of coupling residue; Usually＞0) and N (the point penalty value of the residue that do not match; Usually＜0) calculate the accumulation score value.When: accumulation comparison value from its maximum value of obtaining quantity X that descended; Owing to accumulated one or more negative score value residues comparisons, accumulated value reach zero or below; Or when arriving in two sequences any one end, the word on each direction hits to extend and stops.BLASTN algorithm parameter W, the susceptibility and the speed of T and X decision comparison.Blast program (for nucleotide sequence) is with 11 word length (W), with 10 expected value (E) as default value, with BLOSUM62 score matrix (seeing Henikoff and Henikoff (1989) Proc.Natl.Acad.Sci.USA 89:10915) comparison, (B) be 50, expected value (E) is 10, M=5, N=-4 also compares two chains.

Preferably, " sequence identity per-cent " is decided by the sequences that compare two best comparisons at least in the contrast window in 20 sites, wherein contrasting the part of polynucleotide sequence in the window compares with the reference sequences (do not comprise and add or disappearance) of the best comparison of two sequences, can comprise percent 20 or interpolation still less or disappearance (being breach), common percent 5 to 15, or percent 10 to 12.The calculating of per-cent is counted to obtain match bit by determining the number of sites that occurs the identical nucleic acid base in two sequences, and match bit is counted divided by the site sum of reference sequences (being window size), and the result multiply by 100 and obtains sequence identity per-cent.

Those of ordinary skills will figure out, and the degeneracy result of genetic code has many nucleotide sequence coded polypeptide described here.The nucleotide sequence of some and any natural gene has minimum homology in these polynucleotide.Yet, because codon usage variance and different polynucleotide comprise in the present invention especially.Further, the allelotrope that the polynucleotide sequence that provides here is provided within the scope of the invention.Allelotrope is owing to one or more sudden changes endogenous gene of changing of nucleotide deletion, interpolation and/or displacement for example.The mRNA of gained and albumen can but be not essential recurring structure or changing function.Use standard technique can identify allelotrope (for example hybridize, amplification and/or database sequence relatively).

Therefore, in another embodiment of the invention, adopt mutafacient system, site-directed mutagenesis for example prepares the immunogenicity varient and/or the derivative of polypeptide described herein.Use this method, undertaken the specificity of peptide sequence is modified by the mutagenesis polynucleotides encoding them.These technology provide preparation and have detected the direct method of sequence variant, for example, introduce one or more aforementioned Considerations by one or more nucleotide sequences being changed the importing polynucleotide.

Site-directed mutagenesis can produce mutant, expect the specific oligonucleotide sequences of the dna sequence dna of sudden change by using coding, and primer sequence and the order complicacy of the adjacent nucleotide of sufficient amount so that enough sizes to be provided, form stable duplex in the both sides, disappearance junction of being crossed.Can in selected polynucleotide sequence, utilize sudden change to improve, change, reduce, modify or change the performance of polynucleotide itself, and/or change performance, activity, composition, the stability of encoded polypeptides, or primary sequence.

In certain embodiments of the invention, the inventor estimates that the disclosed polynucleotide sequence of mutagenesis can change one or more performances of encoded polypeptides, for example immunogenicity of polypeptide vaccine.Side-directed mutagenesis is well known in the art, and is widely used in the varient that produces polypeptide and polynucleotide.For example, usually use site-directed mutagenesis to change the specific part of dna molecular.In this embodiment, use length to comprise about 14 primers to about 25 Nucleotide usually, wherein about 5 to the junction both sides of about 10 residues in sequence to be changed.

Those skilled in the art will figure out, and side-directed mutagenesis usually uses the phage vector that exists with strand and double chain form.The typical carriers that is used for site-directed mutagenesis comprises for example M13 phage of carrier.These phages are easily from commercial acquisition, and its use is normally well known to those skilled in the art.Double-stranded plasmid also is used for site-directed mutagenesis by routine, gets rid of the step of gene of interest being transferred to phage from plasmid.

Usually, the enforcement of the site-directed mutagenesis here is by at first obtaining single-stranded vector or two chains of double-stranded carrier are unwind, and carrier comprises the dna sequence dna of coding expectation peptide in its sequence.Preparation contains the Oligonucleolide primers of expecting mutant nucleotide sequence, passes through synthetic method usually.Then, this primer and single-stranded vector annealing, and add for example Escherichia coli polymerase IKlenow fragment of archaeal dna polymerase, contain the synthetic of sudden change chain to finish.Therefore, formed heteroduplex, former beginning and end mutant nucleotide sequence of chain encoding wherein, the second chain contains the sudden change of expectation.Then this heteroduplex carrier is used to transform suitable cell, Bacillus coli cells for example selects to comprise the clone who contains the recombinant vectors that mutant nucleotide sequence resets.

Use the sequence variant of the dna fragmentation of the selected peptide of site-directed mutagenesis preparation coding, provide and produced the method for the species of potentially useful, and do not mean that restriction has other method can obtain the sequence variant of peptide and their dna sequence dna of coding.For example, can use mutagenic compound, azanol for example, the recombinant vectors of handling the peptide sequence of coding expectation obtains sequence variant.About the detail of these methods and scheme in Maloy etc., 1994; Segal, 1976; Prokop and Bajpai, 1991; Kuby, 1994; With Maniatis etc., find in 1982 the instruction, for that purpose with every piece of introducing here as a reference.

Term used herein " oligonucleotide directed mutagenesis step " is meant template dependency process and carrier mediated propagation, causes the concentration of specific nucleic acid molecule to increase with respect to its initial concentration, or the increase of detectable signal concentration, as amplification.Term used herein " oligonucleotide directed mutagenesis step " is intended to refer to comprise the process that the template dependency of primer molecule is extended.Term template dependency process is meant that the nucleic acid of RNA or dna molecular is synthetic, and wherein the sequence of new synthetic nucleic acid chains is specified (seeing Watson for example, 1987) by the base complementrity pairing rules of knowing.Typically, carrier mediated method comprises nucleic acid fragment imported DNA or RNA carrier, the clonal expansion of carrier and reclaim the nucleic acid fragment of amplification.United States Patent (USP) 4,237,224 provide this methodological example, are incorporated herein by reference especially with its complete form here.

Produce in the method for polypeptide variants of the present invention at another, can use, 458 described recursion sequence reorganization as United States Patent (USP) 5,837.In this method, circulation is implemented reorganization and screening or is selected to have for example immunogenic each polynucleotide varient of the present invention of enhanced with " development " repeatedly.

In other embodiments of the present invention, the polynucleotide sequence that provides here can be advantageously used for the probe or the primer of nucleic acid hybridization.Estimate thus to comprise have the sequence identical with the continuous sequence sequence of 15 Nucleotide of length disclosed herein or with it the nucleic acid fragment of the sequence area of the continuous sequence of about at least 15 Nucleotide of complementary length with particularly useful.Longer successive is equal to or complementary sequence, for example, and about 20,30,40,50,100,200,500,1000 (comprising all intermediate lengths) and even also will be used for some embodiment up to the sequence of full length sequence.

The ability of this nucleic acid probe and sequence-specific interested hybridization will make them can be used in the existence that detects complementary sequence in the given sample.Yet also can envision other purposes, for example sequence information is used to prepare the mutant primer, or be used to prepare the primer of other genetic construction.

Have by 10-14,15-20,30,50, or even 100-200 Nucleotide about the polynucleotide molecule of the sequence area formed of continuous nucleotide section (also comprising intermediate length), be equal to or complementation with polynucleotide sequence disclosed herein, special consideration is used as hybridization probe in as southern blotting technique and RNA trace.This will make gene product or its fragment can analyze in various bacterial cells in the broad variety cell and also.Segmental total size, and the size of complementary section will finally depend on segmental intended use of specific nucleic acid or application.Littler fragment will be generally used in the crossing scheme, and wherein continuously the length in complementary district can change, for example about 15 and about 100 Nucleotide between, but, can use longer continuous complementary section according to the complementary sequence length that expectation detects.

Using length is that the hybridization probe of about 15-25 Nucleotide allows to form and not only stablizes but also duplex molecule selectively.Although for stability and the selectivity that increases hybridization, preferably have the molecule of continuous complementary sequence spanning length usually, and therefore improve the quality and the degree of resulting specific hybridization molecule greater than 15 bases.People understand the nucleic acid molecule that preferred design has the gene complementation section of 15 to 25 continuous nucleotides usually, or the words of expectation even longer.

Hybridization probe can be selected from any part of any sequence disclosed herein.The needed sequence of enumerating here of just browsing, or wish length any sequential portion from about 15-25 Nucleotide to the sequence that comprise full length sequence of utilization as probe or primer.The selection of probe and primer sequence can be subjected to the control of various factors.For example, can wish to use primer from trending towards the complete sequence end.

Can prepare little polynucleotide section or fragment at an easy rate,, as use that automatic oligonucleotide synthesizer is common to carry out for example by the directly synthetic fragment of chemical process.And fragment also can be by using the nucleic acid replication technology, and for example United States Patent (USP) 4,683, the PCR of 202 (being incorporated herein by reference here) ^TMTechnology is used to produce recombinant chou and obtains by biology field technician other recombinant DNA technology known to usually by selected sequence being imported recombinant vectors.

Can use nucleotide sequence of the present invention, because they have the ability that forms the duplex molecule with the complementary section selectivity of complete genome or interested gene fragment.According to the application of anticipation, people can expect to utilize different hybridization conditions to obtain the different choice degree of probe to target sequence usually.For the application that needs highly selective; people can expect to utilize strict relatively condition to form hybrid usually, for example, can select low relatively salt and/or high temperature condition; for example provide from about 0.02M to the about salt concn of 0.15M, from about 50 ℃ to about 70 ℃ temperature.This selective conditions tolerance is few, and if any, probe and template or the mispairing of target interchain will be particularly suitable for separating correlated series.

Certainly, for some application, for example, when expectation utilizes the mutant primer chain of hybridizing with foundation forms to prepare mutant, in order to allow to form the hybridization conditions that heteroduplex typically needs more undemanding (severity reduction).In these cases, can expect to utilize for example salt condition from about 0.15M to about 0.9M salt, temperature range is from about 20 ℃ to about 55 ℃.Therefore can be easy to identify the cross hybridization kind, it positive hybridization signal occurs with respect to contrast hybridization.Under any circumstance, can figure out the methane amide that adds increasing amount usually and can make condition more strict, it makes hybrid double-stranded unstable to increase identical pattern with temperature.Therefore, hybridization conditions can be easy to handle, and this will be a kind of method that depends on the result of expectation and select usually.

According to another embodiment of the invention, provide the polynucleotide compositions that comprises antisense oligonucleotide.Verified antisense oligonucleotide is effective and directed protein synthesis inhibitor, and therefore provides by suppressing to cause that the albumen of disease synthesizes the treatment of diseases method for the treatment of.Antisense oligonucleotide arrestin synthetic effect is proved well.For example, synthetic can the inhibition of polygalacturonase and muscarine 2 type acetylcholine receptors (United States Patent (USP) 5,739,119 and United States Patent (USP) 5,759,829) by antisense oligonucleotide at its mRNA sequence separately.In addition, the example of Antisense Suppression is at the nuclear protein cyclin, and multidrug resistant gene (MDG1), ICAM-1, E-are selected plain, STK-1, striatum GABA _A(Jaskulski etc., Science.1988 Jun10 are confirmed among acceptor and the people EGF; 240 (4858): 1544-6; Vasanthakumar and Ahmed, CancerCommun.1989; 1 (4): 225-32; Peris etc., Brain Res MolBrain Res.1998 Juh 15; 57 (2): 310-20; United States Patent (USP) 5,801,154; United States Patent (USP) 5,789,573; United States Patent (USP) 5,718,709 and United States Patent (USP) 5,610,288).Also describe antisense constructs and suppressed and can be used for treating multiple abnormal cell proliferation, for example cancer (United States Patent (USP) 5,747,470; United States Patent (USP) 5,591,317 and United States Patent (USP) 5,783,683).

Therefore, in certain embodiments, the invention provides oligonucleotide sequence, it comprise all or part of can specificity in conjunction with any sequence of polynucleotide sequence described herein or its complement.In one embodiment, antisense oligonucleotide comprises the DNA or derivatives thereof.In another embodiment, oligonucleotide comprises the RNA or derivatives thereof.In the 3rd embodiment, oligonucleotide is the modified DNA that comprises thiophosphoric acid modification skeleton.In the 4th embodiment, oligonucleotide sequence comprises the peptide nucleic acid(PNA) or derivatives thereof.In each case, preferred composition comprises complementary and more preferably complementary substantially and even the more preferably complete complementary sequence area with one or more parts of polynucleotide disclosed herein.Selection is determined Tm, bound energy and relative stability to what the specific antisense composition of given gene order was based on the analysis of selected target sequence and secondary structure.The antisense composition can based on its do not form relatively can reduce or forbid with host cell in the ability of purpose mRNA specificity bonded dimer, hair clip or other secondary structure select.The target area of mRNA very preferably be positioned at or near the AUG translation initiation codon and basically with mRNA 5 ' district those sequences of complementary.V.4 and/or BLASTN2.0.5 algorithm software (Altschul etc., Nucleic Acids Res.1997,25 (17): 3389-402) implement these secondary structure analysis and target site for example select to consider to use OLIGO primer analysis software.

Also can consider to adopt and use the small peptide carrier, the antisense that is called MPG (27 residues) send the method for passing.The MPG peptide contains from HIV gp41 with from hydrophobic region (Morris etc., the Nucleic Acids Res.1997Jul 15 of the fusion sequence of the antigenic nuclear localization sequence hydrophilic area of SV40 T; 25 (14): 2730-6).Verified several MPG peptide molecule bag also can be delivered in the mammalian cell of cultivation with high relatively efficient (90%) in less than 1 hour by antisense oligonucleotide.In addition, the interaction with MPG increases oligonucleotide strongly to the stability of nuclease and the ability of passing plasma membrane.

According to another embodiment of the invention, polynucleotide compositions described herein is used for relating to and prepare ribozyme molecule to be used to suppress the expression at tumour cell of oncopeptide of the present invention and albumen.Ribozyme is the RNA-protein complexes that cuts nucleic acid in the locus specificity mode.Ribozyme have and possess the active specificity catalytic domain of endonuclease (Kim and Cech, ProcNatl Acad Sci U S is Dec A.1987; 84 (24): 8788-92; Forster and Symons, Cell.1987 Apr 24; 49 (2): 211-20).For example, a large amount of ribozymes quicken phosphoester transfer with high degree of specificity, usually only cut one of several phosphoric acid ester in the oligonucleotide substrate (Cech etc., Cell.1981 Dec; 27 (3 Pt 2): 487-96; Michel and Westhof, J Mol Biol.1990 Dec 5; 216 (3): 585-610; Reinhold-Hurek and Shub, Nature.1992 May 14; 357 (6374): 173-6).This specificity requirement substrate before chemical reaction interacts in conjunction with the inside homing sequence (" IGS ") of ribozyme by the specificity base pairing.

Six basic mutation of the enzyme RNA of known natural generation now.Every kind can be in the hydrolysis of (so can cut other RNA molecule) in transit of catalysis RNA phosphodiester bond under the physiological condition.Usually, enzyme nucleic acid is by playing a role in conjunction with target RNA earlier.This combination occurs in the target bound fraction of enzyme nucleic acid, and it is approaching with the enzyme part of the described molecule of cutting target RNA.Therefore, enzyme nucleic acid is at first discerned and is then matched in conjunction with target RNA by base complementrity, in case be attached to correct site, promptly brings into play enzymatic action cutting target DNA.The tactic cutting of this target RNA will destroy the synthetic ability that it instructs proteins encoded.Behind the combination of enzyme nucleic acid and its RNA target of cutting, it is discharged to make a return journey by that RNA and searches other target and can repeat the combination target new with cutting.

The zymologic property of ribozyme has superiority than many technology, and antisense technology (wherein nucleic acid molecule only bind nucleic acid target block its translation) for example is because treat the concentration that necessary ribozyme concentration is lower than antisense oligonucleotide.This advantage has reflected the ability that ribozyme carries out enzymatic action.Therefore, single ribozyme molecule can cut many target RNA molecules.And ribozyme is the high degree of specificity inhibitor, and its inhibition specificity not only depends on the base pairing mechanism in conjunction with target RNA, but also depends on the mechanism of target RNA cutting.The catalytic activity that can eliminate ribozyme fully near the single mispairing or the base substitution of cleavage site.In the antisense molecule similarly mispairing can not stop its effect (Woolf etc., Proc Natl Acad Sci U S is Aug 15 A.1992; 89 (16): 7305-9).Therefore, the specificity of ribozyme effect is higher than the antisense oligonucleotide in conjunction with identical RNA site.

The enzyme nucleic acid molecule can form hammerhead shape, hair clip shape, hepatitis Γ virus, I group intron or RNA enzyme P RNA (relevant with the RNA guide sequence) or neurospora VS RNA primitive.The example of hammerhead shape primitive is at .Nucleic Acids Res.1992 Sep11 such as Rossi; 20 (17): describe among the 4559-65.The example of hair clip shape primitive is documented in (European patent application publication No. EP 0360257) such as Hampel, Hampel and Tritz, Biochemistry 1989 Jun 13; 28 (12): 4929-33; Hampel etc., NucleicAcids Res.1990 Jan 25; 18 (2): 299-304 and United States Patent (USP) 5,631,359.Hepatitis Γ virus primitive is at Perrotta and Been, Biochemi stry.1992 Dec 1; 31 (47): describe among the 11843-52; The example of RNA enzyme P primitive is at Guerrier-Takada etc., Cell.1983 Dec; 35 (3 Pt 2): describe among the 849-57; Neurospora VS RNA ribozyme primitive is at Collins (Saville and Collins, Cell.1990 May18; 61 (4): 685-96; Saville and Collins, Proc Natl AcadSci USA.1991 Oct 1; 88 (19): 8826-30; Collins and Olive, Biochemistry.1993 Mar 23; 32 (11): describe 2795-9); And I group intron is described in (United States Patent (USP) 4,987,071).In enzyme nucleic acid molecule of the present invention importantly it have with one or more and target gene RNA district complementary specific substrate binding site and it in this substrate binding site or have the nucleotide sequence of giving described molecule RNA nicking activity on every side.Therefore, the ribozyme construct special primitive that is not necessarily limited to mention here.

Can described in International Patent Application Publication No. WO 93/23569 and International Patent Application Publication No. WO 94/02595, design ribozyme (every piece of special introducing is used for referencial use here), and synthesize as described to detect in vitro and in vivo.This ribozyme also can be optimized and is used to send.Although concrete example is provided, those skilled in the art will recognize that and to utilize RNA target equal in other species when needing.

Ribozyme activity can be optimized, by changing the length of ribozyme brachium conjunctivum, or the chemosynthesis ribozyme, have prevent its by the modification of serum Yeast Nucleic Acid enzyme liberating (as seeing International Patent Application Publication No. WO 92/07065; International Patent Application Publication No. WO 93/15187; International Patent Application Publication No. WO 91/03162; European patent application publication No. 92110298.4; United States Patent (USP) 5,334,711; With International Patent Application Publication No. WO 94/13688, these document descriptions the various chemically modifieds that can carry out the sugar moieties of enzyme RNA molecule), strengthen the modification of their effects in cell and remove stem district II base to shorten the RNA generated time and to reduce chemical requirement.

Sullivan etc. (International Patent Application Publication No. WO 94/02595) have described the general method of enzyme delivery RNA molecule.Ribozyme can give cell by the whole bag of tricks known to the those of ordinary skill in the art, includes but not limited to, and liposome packing, iontophoresis or introduce other carrier is as hydrogel, cyclodextrin, biodegradable micro-capsule and bioadhesive microsphere.For some indication, ribozyme can with or directly exsomatize to send without aforementioned bearer and pass cell or tissue.Alternatively, the RNA/ carrier combinations can be by directly suction, direct injection or use conduit, and infusion pump or support part are sent and are passed.Other send that the approach of passing includes but not limited in the blood vessel, intramuscular, subcutaneous or joint injection, aerosol suck, send in oral (tablet or pill), part, whole body, eye, intraperitoneal and/or the sheath and pass.Ribozyme send to pass with being described in more detail in International Patent Application Publication No. WO 94/02595 and International Patent Application Publication No. WO 93/23569 of administration and provides, every piece of special introducing here as a reference.

Another method of accumulation high density ribozyme is that the sequence of encoding ribozyme is mixed in the DNA expression vector in cell.Ribozyme sequence transcribe promoters driven by eucaryotic RNA polysaccharase I (pol I), rna plymerase ii (pol II) or rna plymerase iii (pol III).From the transcript of pol II or pol III promotor will be in all cells high level expression; Near the character (enhanser, silencer etc.) of the gene regulating sequence that will exist the given level of pol II promotor in given cell type will depend on.Also can use the prokaryotic rna polymerase promotor, as long as prokaryotic rna polymerase is expressed in suitable cell.Shown that the ribozyme by this promoter expression has function in mammalian cell.This transcription unit can be incorporated in the various carriers and import mammalian cell, include but not limited to the plasmid DNA carrier, viral DNA carrier (for example adenovirus or adeno-associated virus vector), or viral rna vector (as retrovirus, match nurse niche forest virus, sindbis virus carrier).

In another embodiment of the invention, provide peptide nucleic acid(PNA) (PNAs) composition.PNA is the analog D NA (Good and Nielsen, Antisense Nucleic Acid Drug Dev.1997 7 (4) 431-37) that the nuclear base links to each other with pseudopeptide backbone.PNA can be used in many methods that tradition is used RNA or DNA.Usually the PNA sequence shows better than corresponding RNA or dna sequence dna in technology and has non-RNA or DNA inherent purposes.The summary of preparation method, feature and using method that comprises PNA is by Corey (TrendsBiotechnol 1997 Jun; 15 (6): 224-9) provide.Thus in certain embodiments, can prepare one or more part complementary PNA sequences with ACE mRNA sequence, and this PNA composition can be used to regulate, change, reduce or reduce the translation of ACE specific mrna, and therefore changes the ACE activity level in the host cell of using this PNA composition.

PNA has 2-aminoethyl glycine bonding (Nielsen etc., Science 1991 Dec 6 that replace the normal DNA phosphodiester backbone; 254 (5037): 1497-500; Hanvey etc., Science.1992 Nov 27; 258 (5087): 1481-5; Hyrup and Nielsen, Bioorg Med Chem.1996 Jan; 4 (1): 5-23).This chemical structure has three important results: at first, compare with DNA or phosphorothioate oligonucleotide, PNA is a neutral molecule; Secondly, PNA is an achirality, avoids carrying out solid and selects the synthetic needs; With the 3rd, synthetic solid-phase peptide synthetic standard Boc or the Fmoc scheme used of PNA was although also once used other method to comprise the Merrifield method of improvement.

(Framingham MA) can commercial buy PNA monomer or ready-made oligomer from PerSeptive Biosystems.All be to use artificial or automatic scheme directly synthetic (Norton etc., Bioorg Med Chem.1995 Apr with Boc or the synthetic PNA of Fmoc scheme; 3 (4): 437-45).Manual approach makes and himself produces through the PNA of chemically modified or synthetic closely-related simultaneously PNA family.

Synthetic for peptide, specific PNA synthetic successfully depends on the performance of selected sequence.For example, although the PNA combination that can mix any nucleotide base in theory, the existence of contiguous purine can cause one or more residues disappearances in the product.Predict this difficulty, suggestion should repeat the residue of the invalid adding of coupling possibility when generation has the PNA of contiguous purine.Should provide to be similar to observed product output and purity in the peptide building-up process with anti-phase high pressure liquid chromatography purifying PNA after this.

PNA modified to be connected with the N-terminal amine of exposure by the compound that coupling amino acid during solid phase synthesis maybe will contain hydroxy-acid group at given application finish.Alternatively, can modify PNA by the Methionin or the halfcystine that are coupled to introducing in synthetic back.PNAs can be easy to be modified be beneficial to it is optimized to has better solubleness or at special function needs.In case after synthetic, can carry out the evaluation of PNAs and its derivative with mass spectrometry.Several researchs have prepared and have utilized the modification of PNA.(for example, Norton etc., Bioorg Med Chem.1995 Apr; 3 (4): 437-45; Petersen etc., J.Pept Sci.1995 May-Jun; 1 (3): 175-83; Orum etc., Biotechniques.1995 Sep; 19 (3): 472-80; Footer etc., Biochemistry.1996 Aug 20; 35 (33): 10673-9; Griffith etc., Nucleic Acids Res.1995 Aug 11; 23 (15): 3003-8; Pardridge etc., Proc Natl Acad Sci USA.1995 Jun 6; 92 (12): 5592-6; Boffa etc., Proc Natl Acad Sci U S is Mar 14 A.1995; 92 (6): 1901-5; Gambacorti-Passerini etc., Blood.1996 Aug15; 88 (4): 1411-7; Armitage etc., Proc Natl Acad Sci U SA.1997 NoV 11; 94 (23): 12320-5; Seeger etc., Biotechniques.1997 Sep; 23 (3): 512-7).United States Patent (USP) 5,700,922 have discussed PNA-DNA-PNA chimeric molecule and the albumen in diagnosis, adjusting organism and treatment thereof to treating the purposes in the responsive illness.

At Rose (Anal Chem.1993 Dec 15; 65 (24): 3545-9) and (Biochemistry.1997 Apr 22 such as Jensen; 36 (16): the method that characterizes the antisense bonding properties of PNA has been discussed 5072-7).Rose uses capillary gel electrophoresis to determine combining of PNA and its complementary oligonucleotide, measures relative binding kinetics and stoichiometry, and Jensen etc. use BIAcore ^TMTechnology has been carried out the measurement of similar type.

Other application with PNA will be clearly to those skilled in the art that described comprises and is used for the separating of the intrusion of DNA chain, Antisense Suppression, mutation analysis, transcriptional enhancer, nucleic acid purification, transcriptional activity gene, the blocking-up of transcription factor bonded, genome cutting, biosensor, in situ hybridization or the like. Polynucleotide are identified, are characterized and express

The technology of using various establishments is (generally referring to Sambrook etc., MolecularCloning:A Laboratory Manual, Cold Spring HarborLaboratories, Cold Spring Harbor, NY, 1989 and other similar reference) in anyly can identify, prepare and/or operate polynucleotide compositions of the present invention.For example, can identify polynucleotide, following more detailed description by the tumour correlated expression in the screening cDNA microarray (that is, using the representative test that provides to be determined at the high expression of twice at least in the tumour than in healthy tissues) here.Can use for example Affymetrix, Inc. (Santa Clara, CA) microarray technology, according to the operation instruction of manufacturers (substantially as Schena etc., Proc.Natl.Acad.Sci.USA 93:10614-10619,1996 and Heller etc., Proc.Natl.Acad.Sci.USA 94:2150-2155,1997 is described) implement this screening.Alternatively, can be by the cDNA amplification polynucleotide that from express proteic cell described here such as tumour cell, prepare.

The interested target sequence that many template dependency methods exist in can amplified sample.One of amplification method of knowing the most is polymerase chain reaction (PCR ^TM), at United States Patent (USP) 4,683, describe in detail in 195,4,683,202 and 4,800,159, introduce here as a reference with its complete form for every piece.In brief, at PCR ^TMIn, two primer sequences of the regional complementarity on the opposed complementary chain of preparation and target sequence.In reaction mixture, add excessive deoxynucleoside triphosphate, and archaeal dna polymerase (as the Taq polysaccharase).If there is target sequence in the sample, primer will combine with target, and the logical plus nucleotide that attaches of polysaccharase makes primer prolong the target sequence extension.By improving and reduce the temperature of reaction mixture, the primer of extension will with the target formation reaction product of dissociating, excessive primer will combine with target and reaction product, repeat this process.For the amount of the mRNA of quantitative amplification, preferably can implement reverse transcription and PCR ^TMAmplification step.Polymerase chain reaction method is well known in the art.

Any method in a large amount of other template dependency methods, wherein many is PCR ^TMThe modification of amplification technique is that this area is known easily and utilized.Illustrate, some this methods comprise ligase chain reaction (LCR) (being called LCR), describe in for example European patent application publication No. 320,308 and United States Patent (USP) 4,883,750; The Qbeta replicative enzyme is described in pct international patent application publication number PCT/US87/00880; Strand displacement amplification (SDA) and reparation chain reaction (RCR).There is other amplification method in GB Patent Application No. 2202328 and pct international patent application publication number PCT/US89/01025, to describe again.Other nucleic acid amplification step comprises based on the amplification system of transcribing (TAS) (pct international patent application publication number WO 88/10315), comprises amplification (NASBA) and 3SR based on nucleotide sequence.European patent application publication No. 329,822 has been described a kind of nucleic acid amplification method and has been comprised circulation synthesizing single-stranded RNA (" ssRNA "), ssDNA and double-stranded DNA (dsDNA).Pct international patent application publication number WO 89/06700 has described the amplification of nucleic acid sequences scheme, based on the hybridization of promotor/primer sequence and target single stranded DNA (" ssRNA "), transcribes many RNA copies of this sequence then.Other amplification method for example " RACE " (Frohman, 1990) and " sex-limited PCR (one-sided PCR) " (Ohara, 1989) also is well known to those skilled in the art.

The technology that use is known, the amplification part of polynucleotide of the present invention can be used for (as tumour cDNA library) separation full-length gene from suitable library.In this technology, use the one or more polynucleotide probes or primer screening library (cDNA or the genome) that are fit to amplification.Preferably, the library is selected by size, comprises than macromole.Also preferably 5 ' and upstream of random primer library identified gene.Preferred gene group library is used to obtain intron and extends 5 ' sequence.

For hybridization technique, can use know the technical mark partial sequence (as, by nick translation or usefulness ³²The P end mark).Usually the filter lawn of plaque (or contain) screening bacterium or the phage library that contains the sex change bacterium colony with label probe hybridization (seen Sambrook etc., Molecular Cloning:A Laboratory Manual then; Cold SpringHarbor Laboratories, Cold Spring Harbor, NY, 1989).Select and expand the bacterium colony or the plaque of hybridization, DNA isolation is done further to analyze.Can analyze the amount that cDNA clone determines appended sequence, for example by using from the primer of partial sequence with from the PCR of the primer of carrier.Can produce restriction map and partial sequence and identify one or more overlapping clones.Determine complete sequence with standard technique then, described technology can comprise a series of deletion clones of generation.The gained overlap can be assembled into single continuous sequence then.Technical battery's suitable fragment of joint is known in use can produce the full-length cDNA molecule.

Alternatively, amplification technique, as previously discussed those can be in order to obtain complete encoding sequence from Partial cDNA Sequence.A kind of such amplification technique is inverse PCR (seeing Triglia etc., Nucl.Acids Res.16:8186,1988), and its uses Restriction Enzyme to be created in fragment in the known region of gene.Connect with this fragment cyclisation and as using the template of carrying out PCR from the dispersion primer of known zone by intramolecularly then.In alternative method, using increases at the primer of joint sequence with to the specific primer of known region can regain the sequence contiguous with partial sequence.Usually the sequence of amplification is carried out second and take turns amplification, use identical joint primer and the specific second primer of known region.Described the modification of this step among the WO 96/38591, it utilizes two primers that begin in the opposite direction to extend from known array.This technology is known is " rapid amplifying cDNA end " or RACE for another.This technology comprises uses inner primer and outer primer, and it and polyadenylic acid district or carrier sequence hybridization are with 5 ' and 3 ' the sequence of evaluation at known array.Other technology comprises catches PCR (Lagerstrom etc., PCR Methods Applic.l:111-19,1991) and walking PCR (Parker etc., Nucl.Acids.Res.19:3055-60,1991).Also can adopt other method of utilizing amplification to obtain full length cDNA sequence.

In some cases, by the sequence that provides in expressed sequence mark (EST) database is provided, for example the sequence that can obtain from GenBank may obtain full length cDNA sequence.Usually can use and know program (as NCBI BLAST retrieval) and retrieve overlapping ESTs, and this ESTs can be used to produce the successive full length sequence.Analyzing gene group fragment also can obtain the full length DNA sequence.

In other embodiments of the present invention, the polynucleotide sequence of code book invention polypeptide or fusion rotein or its functionally equivalent or its fragment can be used for recombinant DNA molecules to instruct the expression of polypeptide in appropriate host cell.Because the intrinsic degeneracy of genetic code, other dna sequence dna and these sequences that can produce the aminoacid sequence of encode basic identical or functional equivalent can be used to clone and express given polypeptide.

As skilled in the art will understand, have non-natural and exist the nucleotide sequence of the coded polypeptide of codon to have advantage producing in some cases.For example, can select the preferred codon of specific protokaryon or eucaryon host to increase the recombinant RNA transcript that protein expression rate or generation have expected performance, for example the transformation period is than long from the natural transcript that exists sequence to produce.

In addition, change the sequence of coded polypeptide for a variety of causes, can use the method for this area known to general to transform polynucleotide sequence of the present invention, include but not limited to change clone, processing and/or the expression of gene product.For example, re-assembly as PCR by random fracture with gene fragment and synthetic oligonucleotide and carry out DNA reorganization and can be used to transform nucleotide sequence.In addition, site-directed mutagenesis can be used for inserting new restriction site, changes glycosylation pattern, changes codon and selects, produces splice variant or import sudden change or the like.

In another embodiment of the invention, nucleotide sequence natural, that modify or reorganization can be connected with encoding fusion protein with heterologous sequence.For example, for screening the inhibitor that peptide library obtains polypeptide active, it can be used for encoding and can obtain the chimeric protein that antibody is discerned for commerce.Also can transform fusion rotein it is contained at the sequence of coded polypeptide and the cleavage site between the heterologous protein sequence, make polypeptide to be cut and purifying from the allos part.

Use chemical process well known in the art (to see Caruthers, (1980) Nucl.Acids Res.Symp.Ser.215-223 such as M.H., Horn, T. etc. (1980) Nucl.Acids Res.Symp.Ser.225-232) sequence that can all or part of composite coding expectation polypeptide.Alternatively, can produce albumen itself with the synthetic amino acid sequence of polypeptide of chemical process or its part.For example, can use various solid phase techniques to carry out peptide synthetic (Roberge, J.Y. etc. (1995) Science 269:202-204), and automatic synthesis method for example can use ABI 431A peptide synthesizer, and (Perkin Elmer, PaloAlto CA) finish.

With preparation type high performance liquid chromatography (as Creighton, T. (1983) Proteins, Structures and Molecular Principles, WH Freeman and Co., New York, N.Y.) or available other similar techniques in this area new synthetic peptide of purifying basically.The composition of synthetic peptide can confirm by amino acid analysis or order-checking (as the Edman degradation method).In addition, the aminoacid sequence of polypeptide or its any part can change and/or use chemical process and combined sequence from other albumen or its any part in direct building-up process, produce the variation polypeptide.

In order to express the polypeptide of expectation, the nucleotide sequence of coded polypeptide or its functionally equivalent can be inserted in the suitable expression vector,, contains the carrier of the essential element of the encoding sequence of transcribing and translate insertion that is.Can make up the sequence that contains the interested polypeptide of encoding and suitable expression vector of transcribing with the translational control element with method well known to those skilled in the art.These methods comprise extracorporeal recombinant DNA technology, synthetic technology and vivo gene reorganization.This technology is at for example Sambrook, (1989) Molecular Cloning such as J., A LaboratoryManual, Cold Spring Harbor Press, Plainview, N.Y., and Ausubel, (1989) Current Protocols in MolecularBiology such as F.M., John Wiley ﹠amp; Sons describes among the New York N.Y..

Can utilize various expression vector/host system to comprise and express polynucleotide sequence.These include but not limited to microorganism, as the bacterium that transforms with recombinant phage, plasmid or cosmid DNA expression vector; Yeast with the Yeast expression carrier conversion; Insect cell system with virus expression carrier (as baculovirus) infection; With virus expression carrier (as cauliflower mosaic virus, CaMV; Tobacco mosaic virus (TMV) is TMV) or with bacterial expression vector (as Ti or pBR322 plasmid) plant transformed cell system; Or zooblast system.

" controlling element " that exists in the expression vector or " regulating and controlling sequence " are that protein-interacting is transcribed and translated in non-translational region-enhanser, promotor, 5 ' and 3 ' non-translational region-they and the host cell of carrier.The intensity of this element and specificity can change.According to carrier system that is utilized and host, can use any amount of suitable element of transcribing and translate, comprise composing type and inducible promoter.For example, when in bacterial system, cloning, can use inducible promoter for example the PBLUESCRIPT phagemid (Stratagene, La Jolla, Calif.) or PSPORT1 plasmid (Gibco BRL, Gaithersburg, heterozygosis lacZ promotor MD) etc.In the mammalian cell system, usually preferably from mammalian genes or from the promotor of mammalian virus.Produce the clone of the sequence that contains the multiple copied coded polypeptide if desired, but use carrier to have advantage based on SV40 or EBV with suitable selective marker is common.

In the bacterium system, can select in the multiple expression vector any according to the purposes of expressed polypeptide tendency.For example, when requirement is big, for example be used to induce generation antibody, the carrier of fusion rotein that can the easy purifying of instruction high level expression.This carrier includes but not limited to, multi-functional escherichia coli cloning and expression vector, BLUESCRIPT (Stratagene) for example, the sequence of the polypeptide of interest of wherein encoding can be connected in the carrier, the frame that meets the sequence of the N-terminal Met of beta-galactosidase enzymes and 7 residues subsequently, thus hybrid protein produced; PIN carrier (Van Heeke, G. and S.M.Schuster (1989) J.Biol.Chem; 264:5503-5509); Or the like.(Promega, Madison is Wis.) as the external polypeptide of expressing fusion protein that forms with glutathione S-transferase (GST) also can to use the pGEX carrier.Usually, this fusion rotein is soluble, and by being easy to purifying from the dissolved cell with gsh-sepharose 4B absorption back wash-out in the presence of free glutathione.The albumen for preparing can be designed to comprise heparin, zymoplasm or factor XA proteolytic enzyme cutting site in this system, make interested cloned polypeptide arbitrarily partly to separate with GST.

At yeast, in the cereuisiae fermentum, can use and contain composing type or inducible promoter, as the variety carrier of alpha factor, alcohol oxidase and PGH.Summary is seen (1987) Methods Enzymol.153:516-544 such as Ausubel etc. (above) and Grant.

Using under the situation of plant expression vector, the expression of the sequence of coded polypeptide can be driven by in the multiple promotor any one.For example, the 35S of viral promotors such as CaMV and 19S promotor can use separately or be used in combination with omega homing sequence from TMV that (Takamatsu, N. (1987) EMBO J.6:307-311.Alternatively, can use the small subunit of plant promoter such as RUBISCO or heat-shocked promotor (Coruzzi, G. etc. (1984) EMBO J.3:1671-1680; Broglie, R. etc. (1984) Science 224:838-843; And Winter, J. etc. (1991) ResultsProbl.Cell Differ.17:85-105).These constructs can import vegetable cell by the transfection that direct DNA transforms or pathogenic agent mediates.This technology in many pieces of common obtainable summaries, state (see, for example, Hobbs, S. or Murry, L.E.in McGrawHill Yearbook of Science and Technology (1992) McGraw Hill, New York, N.Y.; Pp.191-196).

Also can use the insect system to express interested polypeptide.For example, in such system, autographa california nuclear polyhedrosis virus (AcNPV) is expressed alien gene as carrier at the fall army worm cell or in the cabbage looper larva.The sequence of coded polypeptide can be cloned in the nonessential region of virus, polyhedron gene for example, and place under the control of polyhedrin promotor.The successful insertion of the sequence of coded polypeptide will make the polyhedron gene inactivation and produce the recombinant virus that lacks coat protein.Recombinant virus can be used to infect for example fall army worm cell or cabbage looper larva then, can express polypeptide of interest (Engelhard, E.K. etc. (1994) Proc.Natl.Acad.Sci.91:3224-3227) therein.

In mammalian host cell, many expression systems based on virus can obtain usually.For example, as under the situation of expression vector, the sequence of coding polypeptide of interest can be connected to the adenovirus of being made up of late promoter and tripartite leader[and transcribe/translate in the complex body in adenovirus.Can be inserted into virus genomic nonessential E1 or E3 district, obtain can be in the host cell that infects the live virus (Logan, J. and Shenk, T. (1984) Proc.Natl.Acad.Sci.81:3655-3659) of express polypeptide.In addition, can use transcriptional enhancer, for example Rous sarcoma virus (RSV) enhanser is to be increased in the expression in the mammalian host cell.

Special start signal also can be used to make the sequence translation of coding polypeptide of interest more effective, and sort signal comprises ATG initiator codon and flanking sequence.Under sequence, its initiator codon and the upstream sequence of coded polypeptide is inserted into situation in the suitable expression, can not need other transcribing or the translational control signal.Yet, under the situation of having only encoding sequence or its part to insert, should provide external source translational control signal to comprise the ATG initiator codon.And initiator codon should be arranged in correct reading frame to guarantee to translate complete insertion fragment.External source translation element and initiator codon can be various sources, comprise natural and synthetic.Comprise the enhanser that is fit to employed specific cells system, (Scharf, D. etc. (19943 Results Probl.Cell Differ.20:125-162) can improve expression efficiency described in document.

In addition, can regulate the expression of insertion sequence in the expectation mode or process expressed proteic ability and select host cell strain according to it.The modification of this peptide species includes but not limited to, acetylize, carboxylation, glycosylation, phosphorylation, lipidization (lipidation) and acidylate.Cutting " preceding former (prepro) " proteic translation post-treatment of form also can be used for helping correct insertion, folding and/or performance function.Different host cells is CHO for example, COS, and HeLa, MDCK, HEK293 and WI38 have this translation active special cells device in back of generation and characteristic mechanism, can be selected to guarantee correct modification of foreign protein and processing.

For the extended high rate amount is produced recombinant protein, usually preferred stable expression.For example, but can use in same or independent carrier, contain viral source duplicate and/or the expression vector of endogenous Expression element and selectable marker gene transforms the clone of stably express polynucleotide interested.After carrier imports, cell was grown 1-2 days before converting selective medium in enriched medium.The purpose of alternative mark provides the selection resistance, and it exists the growth and the recovery of the cell that allows successful expression importing sequence.The tissue culture technique that can use the pair cell type to be fit to is bred the resistance clone of stable transformed cells.

Can use any amount of selective system to reclaim cell transformed system.These include but not limited to be used in respectively the hsv thymidine kinase (Wigler in tk.sup.-or the aprt.sup.-cell, (1977) Cell 11:223-32 such as M.) and adenine phosphoribosyltransferase (Lowy, I. etc. (1990) Cell 22:817-23) gene.Antimetabolite, microbiotic or Herbicid resistant also can be with the bases that elects; For example, dhfr provides the resistance to methotrexate (Wigler, M. etc. (1980) Proc.Natl.Acad.Sci.77:3567-70); Npt provides the resistance of aminoglycoside, Xin Meisu and G-418 (Colbere-Garapin, F. etc. (1981) J.Mol.Biol.150:1-14); With als or pat provide respectively resistance to chlorsulfuron (chlorsulfuron) and phosphinothricin acetyl transferase (Murry, above).The other gene selected has been described, for example, trpB, it allows cell to utilize indoles to replace tryptophane, or hisD, it allows cell to utilize histidinol (histinol) to replace Histidine (Hartman, S.C. and R.C.Mulligan (1988) Proc.Natl.Acad.Sci.85:8047-31).Witness marking generally uses, as anthocyanin, beta-Glucuronidase and substrate GUS thereof, with luciferase and substrate fluorescein thereof, not only be widely used in the evaluation transformant, also be used for quantitatively being attributable to the amount (Rhodes of the instantaneous or stable protein expression of specific support system, (1995) Methods Mol such as C.A., Biol.55:121-131).

Do not exist although exist/do not exist marker gene to express the interested gene of prompting yet, may need to confirm its existence and expression.For example, if the sequence of coded polypeptide is inserted in the marker gene sequence, the disappearance of marker gene function can be identified the reconstitution cell that contains sequence.Alternatively, marker gene can the be contacted sequence of coded polypeptide places under the single promoter regulation.As the marker gene of inducing or selecting to reply being expressed usually also indication polyphone expression of gene.

Alternatively, can identify the host cell that contains and express the expectation polynucleotide sequence with the various steps known to those skilled in the art.These steps include but not limited to that DNA-DNA or DNA-RNA hybridization and protein biology are measured or immunoassay, comprise for example being used to detect and/or quantitative nucleic acid or proteic technology based on film, solution or chip.

Use is to the specific polyclone of product or monoclonal antibody detects and the various schemes of the expression of mensuration polynucleotide encoding product are known in the art.Example comprises enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA) and fluorescence amplifying cell separator (FACS).For some application may preferably utilize with given polypeptide on the dibit point of monoclonal antibody of two non-interference epi-position reactions based on monoclonal immunoassay, but also can use CBA.These and other is measured especially at Hampton, and R. etc. (1990; Serological Methods, a Laboratory Manual, APS Press, StPaul.Minn.) and Maddox, D.E. etc. (1983, describe in J.Exp.Med.158:1211-1216).

Multiple mark and coupling technology are well known by persons skilled in the art, and can be used for various nucleic acid and determined amino acid.Produce the method that the hybridization probe of mark or PCR probe be used to detect the sequence relevant with polynucleotide and comprise that few mark (oligo-labeling), nick translation, end mark or applying marking Nucleotide carry out pcr amplification.Alternatively, sequence or its any part can be cloned and be entered carrier generation mRNA probe.This carrier is known in the art, can obtain from commercial, and can be by adding suitable RNA polymerase such as T7, the Nucleotide of T3 or SP6 and mark is used for the vitro synthesized RNA probe.These steps can use the available test kit of various commerce to carry out.Operable suitable reporter molecule or mark comprise radionuclide, enzyme, fluorescence, chemoluminescence or developer and substrate, cofactor, inhibitor, magnetic-particle or the like.

Can from cell culture, express and reclaim under the proteic condition and cultivate being fit to interested nucleotide sequence transformed host cells.The sequence and/or the carrier that depend on use, the albumen that reconstitution cell produces can be secreted or be contained in the cell.As skilled in the art will understand, the expression vector that contains polynucleotide of the present invention can be designed to comprise and instruct coded polypeptide to pass through protokaryon or eukaryotic cell membrane excretory signal sequence.Can use other recombination structure that the sequence of coding polypeptide of interest and the nucleotide sequence that coding is beneficial to the polypeptide structure territory of soluble protein purifying are coupled together.This structural domain that is beneficial to purifying includes but not limited to metal chelating peptide, for example allow the Histidine-tryptophane assembly of purifying on fixing metal, the albumin A structural domain of permission purifying on fixing immunoglobulin (Ig), with at FLAGS extension/affinity purification system (ImmunexCorp., Seattle, Wash.) the middle structural domain that utilizes.Can between purification structure territory and coded polypeptide, comprise the joint sequence that can cut, as (Invitrogen.San-Diego Calif.) is beneficial to purifying to factor XA or the specific sequence of enteropeptidase.A this expression vector provides Expression of Fusion Protein, and described fusion rotein contains the nucleic acid of 6 histidine residues before polypeptide of interest and the coding Trx or enteropeptidase cleavage site.Histidine residues is beneficial at IMIAC (fixed metal ion affinity chromatography) and goes up purifying, as Porath, J. etc. (1992, Prot.Exp.Purif.3:263-281) described, and the enteropeptidase cleavage site provides the method for purifying expectation polypeptide from fusion rotein.Kroll, D.J. etc. (1993; DNA Cell Biol.12:441-453) discussion about the carrier that contains fusion rotein has been proposed.

Except recombinant method for production, can use solid phase technique (Merrifield J. (1963) J.Am.Chem.Soc.85:2149-2154) to synthesize and produce polypeptide of the present invention and its fragment by direct peptide.Can use manual skill or automatization to carry out albumen synthesizes.Automatically the synthetic Applied Biosystems 431A peptide synthesizer (Perkin Elmer) that for example can use is finished.Alternatively, can distinguish various fragments of chemosynthesis and use chemical process in conjunction with to produce full-length molecule. Antibody compositions, its fragment and other wedding agent

According to another aspect, the present invention further provides with oncopeptide disclosed herein or its part, varient or derivative immune bonded wedding agent has taken place, for example antibody and its Fab.Antibody or its Fab are stated to combining with polypeptid specificity of the present invention ", " immunity in conjunction with " and/or have " immunologic competence "; if but it with polypeptide with detection level (for example in ELISA measures) reaction, but and under simulated condition nothing to do with polypeptide generation detection reaction not.

Immunity used herein is in conjunction with typically referring to immunoglobulin molecules and the immunoglobulin (Ig) noncovalent interaction to institute's occurrence type between its specific antigen.The intensity or the avidity of immunity binding interactions can be with interactional dissociation constant (K _d) represent wherein less K _dRepresent bigger avidity.Use the immune bonding properties that method well known in the art can quantitative selected polypeptide.This method need be measured antigen binding site/antigenic complex and form and dissociated speed, wherein those rate dependent in the concentration of complex body mating partner, interactional avidity and on both direction to the equal geometry parameter of speed influence.Therefore, " open rate constant (K by calculating concentration with in conjunction with determining with dissociated actual speed rate _On) " and " shutdown rate constant (K _Off) ".K _Off/ K _OnRatio can eliminate the irrelevant parameter of all and avidity, therefore be equal to dissociation constant Kd.Usually see Davies etc. (1990) AnnualRev.Biochem.59:439-473.

" antigen binding site " of antibody or " bound fraction " are meant a part that participates in antigen bonded immunoglobulin molecules.Antigen binding site is formed by the amino-acid residue of the N-terminal variable region (" V ") of heavy chain (" H ") and light chain (" L ").Three difference in height fragments in the V district of heavy chain and light chain are called " hypervariable region ", and it is inserted between the flanking fragment of more conservative being called " framework region " or " FRs ".Therefore term " FR " is meant the aminoacid sequence that between the hypervariable region and contiguous hypervariable region is found naturally in the immunoglobulin (Ig).In antibody molecule, three hypervariable regions of light chain and three hypervariable regions of heavy chain are arranged relative to each other on three-dimensional space and form the antigen mating surface.The three-dimensional surface complementation of antigen mating surface and institute's conjugated antigen, three hypervariable regions of every heavy chain and light chain are called " complementary determining region " or " CDRs ".

Here the representative test provide is provided, and wedding agent can further can be distinguished to be suffered from and the patient of cancer stricken such as lung cancer not.For example, will be preferably suffer among the patient of disease with oncoprotein bonded antibody or other wedding agent and to produce the signal that the indication cancer exists, more preferably about at least 30% patient about at least 20%.Alternatively, or in addition, antibody will produce the negative signal that there is not disease in indication in about at least 90% not cancered individuality.In order to determine whether wedding agent meets this requirement, can as mensuration described here from suffer from and not cancered patient's (determining) biological specimen (as blood, serum, phlegm, urine and/or tumor biopsy) with the standard clinical test in whether exist and wedding agent bonded polypeptide.Preferably, suffering from and the sample of the disease that do not take a disease of the quantity that has significance on the statistics will be measured.Every kind of wedding agent should satisfy above-mentioned standard; Yet, one of skill in the art will recognize that wedding agent can be used in combination to improve susceptibility.

Any reagent that satisfies above-mentioned requirements all can be wedding agent.For example, wedding agent can be the rrna that contains or do not contain peptide component, RNA molecule or polypeptide.In preferred embodiments, wedding agent is antibody or its Fab.Can prepare antibody with any method in the whole bag of tricks known to those of ordinary skills, as see Harlow and Lane, Antibodies:A Laboratory Manual, Cold Spring HarborLaboratory, 1988.Usually, cell culture technology can produce antibody, comprise producing monoclonal antibody described here, or in order to allow recombinant antibodies to produce, by with the antibody gene transfection in suitable bacterium or mammalian cell host.In a technology, the immunogen that will comprise polypeptide is at first injected to any in the multiple Mammals (as mouse, rat, rabbit, sheep or goat).In this step, polypeptide of the present invention can be used as the immunogen of not doing modification.Alternatively, particularly for relatively short polypeptide, if polypeptide and carrier proteins for example bovine serum albumin or keyhole limpet hemocyanin be connected, can cause stronger immunne response.Immunogen is injected to the animal host, preferably mix the one or many booster immunization according to predetermined scheme, and the regular bloodletting of animal.Then, can carry out affinity chromatography by for example using with suitable solid support bonded polypeptide, purifying is to the polyclonal antibody of polypeptid specificity from this antiserum(antisera).

Can be by for example using Kohler and Milstein to the specific monoclonal antibody of interested antigenic peptide, Eur.J.Immunol.6:511-519,1976 and its improvement technology preparation.In brief, these methods comprise that preparation can produce and have the expectation specificity immortal cell line of the antibody of the reactivity of polypeptide of interest (that is, with).This clone can be for example always produces from the splenocyte of the animal of immunity as mentioned above.Then, make the splenocyte infinite multiplication by for example merging with myeloma cell's fusion partner, preferred described myeloma cell and immune animal are isogenic.Can use multiple integration technology.For example, splenocyte and myeloma cell can with the nonionic detergent mixed for several minutes, be layered on low density then and support the hybrid cell growth but do not support on the selective medium that the myeloma cell grows.Preferred selection technology uses HAT (xanthoglobulin, aminopterin, thymidine) to select.Through after the enough time, in usually about 1-2 week, observe the hybridization colony.Select single colony and detect its culture supernatant active at the combination of polypeptide.Preferably have hyperergy and specific hybridoma.

Can from the supernatant of hybridoma colony of growth, separate monoclonal antibody.In addition, can use various technology to increase output, for example hybridoma cell line is expelled to suitable vertebrate host for example in the abdominal cavity of mouse.Can from ascites or blood, gather in the crops monoclonal antibody then.Can from antibody, remove pollutent with routine techniques such as chromatography, gel-filtration, precipitation and extraction.Polypeptide of the present invention can be used for purge process, for example in the affinity chromatography step.

The molecule that therepic use is arranged in a large number known in the art, it comprises the antigen binding site that can demonstrate immune binding characteristic of antibody molecule.The proteolytic ferment papoid preferably cuts the IgG molecule and produces several fragments, and wherein two (" F (ab) " fragments) respectively contain the covalency heterodimer that comprises complete antigen binding site.Stomach en-can cut the IgG molecule and obtain several fragments, comprises " the F (ab ') that contains two antigen binding sites ₂" fragment.By optimization protein hydrolysis cutting IgM, cut IgG or IgA immunoglobulin molecules once in a while, can produce " Fv " fragment.Yet more common use recombinant technology known in the art obtains the Fv fragment.The Fv fragment comprises the non-covalent V that contains antigen binding site _H∷ V _LHeterodimer, it keeps the most antigen recognition and the binding ability of natural antibody molecule.Inbar etc. (1972) Proc.Nat.Acad.Sci.USA 69:2659-2662; Hochman etc. (1976) Biochem 15:2706-2710; With (1980) Biochem 19:4091-4096 such as Ehrlich.

Strand Fv (" sFv ") polypeptide is covalently bound V _H∷ V _LHeterodimer, it is from comprising the V by the joint connection of encoded peptide _H-and V _LThe gene fusion expression of-encoding gene.Huston etc., (1988) Proc.Nat.Acad.Sci.USA 85 (16): 5879-5883.Described big metering method and distinguished chemical structure, with will from the natural gathering in antibody V district-but chemically separated-light polypeptide chain and heavy polypeptide chain be transformed into and can be folded into and the basic similarly sFv molecule of three-dimensional structure of antigen binding site structure.As see the United States Patent (USP) 5,091,513 and 5,132 of Huston etc., 405; United States Patent (USP) 4,946,778 with Ladner etc.

Above-mentioned each molecule comprises heavy chain and light chain CDR group, is inserted in respectively to CDRS to provide support and limit between the heavy chain and light chain FR group of CDRs spatial relation relative to each other.Term used herein " CDR group " is meant three hypervariable regions in heavy chain or light chain V district.From heavy chain or light chain N-terminal, these zones are called " CDR1 " respectively, " CDR2 " and " CDR3 ".Therefore, antigen binding site comprises six CDRs, comprises the CDR group from each heavy chain and light chain V district.The polypeptide that comprises single CDR (as CDR1, CDR2 or CDR3) is called " molecular recognition unit " here.The amino-acid residue that the crystallographic analysis of a large amount of antigen-antibody complexeses has been proved CDRs forms extensive the contact with the institute conjugated antigen, and wherein antigen contact the most widely is and heavy chain CDR3.Therefore, molecular recognition unit mainly is responsible for the specificity of antigen binding site.

Term used herein " FR group " is meant four flanking amino acid sequences of the CDRs framework that constitutes heavy chain or light chain V district CDR group.Some FR residues may contact institute's conjugated antigen; Yet FRs mainly is responsible for the V district and is folded into antigen binding site, the particularly direct FR residue adjacent with CDRs.In FRs, some amino residue and some constitutional features high conservative.In this respect, all V region sequences all contain the inside two sulphur rings of about 90 amino-acid residues.When the V district is folded into binding site, CDRs is rendered as the outstanding cyclic group unit that forms the antigen mating surface.It has been generally acknowledged that the accurate cdr amino acid sequence of the shape that the conserved structure district that has FRs influences CDR ring and be folded into some " standard " structure-do not consider.And known some FR residue participates in non-covalent contact the between stabilization of antibodies heavy chain and light chain interactive domains.

Many " humanization " antibody molecule that comprises from the antigen binding site of non-human immunoglobulin has been described, comprise have that the relevant CDRs with it in rodent V district and human constant region merge chimeric antibody (Winter etc. (1991) Nature 349:293-299; Lobuglio etc. (1989) Proc.Nat.Acad.Sci.USA 86:4220-4224; Shaw etc. (1987) J Immunol.138:4534-4538; With (1987) .Cancer Res.47:3577-3583 such as Brown), before merging, be implanted into rodent CDRs (Riechmann etc. (1988) the Nature 332:323-327 that the people supports FR with suitable people's antibody constant region; Verhoeyen etc. (1988) Science 239:1534-1536; With (1986) Nature 321:522-525 such as Jones) and the rodent CDRs (European Patent Publication No 519,596, on December 23rd, 1992 is open) that supports of the rodent FRs that closes by the reorganization edge.Design these " humanization " molecules and will drop to minimum to the immunne response of not expecting that the anti-human antibody molecules of rodent produces, these reactions limit those parts and treat time length and the validity of using in people's acceptors.

Term used herein " edge closes FRs " and " reorganization edge close FRs " be meant for the heterologous molecule of the antigen binding site that comprises basic reservation all natural FR polypeptide pleated sheet structure is provided, and personnel selection FR residue selectivity replaces the FR residue in rodent heavy chain freely or light chain V district.Edge closes technology and is mainly decided with relative arrangement by the structure of heavy chain in the antigen mating surface with light chain CDR group based on the part binding characteristic of understanding antigen binding site.Davies etc. (1990) Ann.Rev.Biochem.59:439-473.Therefore, only wherein the CDR structure, they each other interaction and the interaction of the rest part in they and V plot structure territory carefully keep, antigen-binding specificity just can be retained in the humanized antibody.By using edge to close technology, the displacement of personnel selection residue selectivity meets with immune outside (as can be near solvent) easily, and the FR residue contains weak immunogenicity to provide, or the edge of basic non-immunogenicity closes the hybrid molecule on surface.

Edge closes method and uses Kabat etc., Sequences of Proteins ofImmunological Interest, the 4th edition, (U.S.Dept.of Health andHuman Services, U.S.Government Printing Office, 1987) sequence data of Hui Bian people's antibody variable region, Kabat be new database and other enterable U.S. and foreign databases (nucleic acid and albumen) more.The amino acid whose solvent accessibility in V district can be inferred out from people and the segmental known three-dimensional structure of mouse antibodies.Closing at edge has two common steps in the mouse antigen binding site.At first, the FRs of interested antibody molecule variable region is compared with the corresponding FR sequence of the people variable region that obtains from above-mentioned source.Then will homologous people V district with mouse amino acid accordingly one by one residue compare.Use recombinant technology well known in the art, the different residue of corresponding part with the people among the residue displacement mouse FR that exists in the personnel selection part.Only, carefully carry out to have the tertiary structure in V plot structure territory for example displacement of proline(Pro), glycine and charge residue of amino-acid residue of remarkably influenced to carry out the residue conversion to small part exposed portions (solvent can be approaching).

By this way, gained " edge closes " mouse antigen binding site is designed to keep mouse CDR residue thus, the residue of basic contiguous CDRs, be accredited as and bury or major part is buried the residue of (solvent can not be approaching), it is believed that and participate in the residue that non-covalent between heavy chain and the light chain structural domain (as static with hydrophobic) contact and think influencing the residue from the conserved structure district of FRs of " standard " tertiary structure that CDR encircles.Then these standards are used to prepare recombinant nucleotide sequence, it can be used for the recombinant human antibody that transfection mammalian cell is expressed the antigen-specific that shows the mouse antibodies molecule with the FRs that the CDRs of murine heavy chain and light chain antigen binding site incorporates into proper manners.

In another embodiment of the invention, monoclonal antibody of the present invention can with one or more therapeutical agent couplings.The suitable medicament of this respect comprises radionuclide, differentiating inducer, medicine, toxin and its derivative.Preferred radionuclide comprises ⁹⁰Y, ¹²³I, ¹²⁵I, ¹³¹I, ¹⁸⁶Re, ¹⁸⁸Re, ²¹¹At and ²¹²Bi.Preferred agents comprises methotrexate and pyrimidine and purine analogue.Preferred differentiating inducer comprises phorbol ester and butyric acid.Preferred toxin comprises ricin, toxalbumin, diphtheria toxin, Toxins,exo-, cholera, gelonin (ribosome inactivating protein of plant), Rhodopseudomonas extracellular toxin, Shigella toxin and Pokeweed antiviral protein.

Therapeutical agent can direct or indirect with suitable monoclonal antibody (as by the joint group) coupling (as covalent bonding).When each all has the substituting group that can react with another kind when medicament and antibody, may directly react between the two.For example, the nucleophilic group above, as amino or sulfydryl, may with carbonyl group-containing groups such as acid anhydrides or the acyl halide above another, or the alkyl (as halogenide) that contains good leavings group reacts.

Alternatively, preferably therapeutical agent and antibody pass through the coupling of joint group.The joint group can play interval action makes antibody and reagent away to avoid the interference to binding ability.The joint group also can be used for increasing the substituent chemical reactivity on reagent or the antibody, therefore increases joint efficiency.The chemical reactivity increase also can help the utilization of the functional group on reagent or the reagent, otherwise with impossible.

Multiple difunctional or poly functional reagent comprises congenerous and exclusive-OR function (as at PierceChemical Co., Rockford, those described in the IL catalogue), all can be used as the joint group, and this for those skilled in the art will be clearly.Can for example realize coupling by amino, carboxyl, sulfydryl or carbohydrate oxidation using residue.Many reference have been described this method, as the United States Patent (USP) 4,671,958 of Rodwell etc.

When therapeutical agent is more effective when the antibody moiety of immunoconjugates of the present invention breaks away from, preferably use in the process of internalization to the cell or the joint group of cleavable at that time.Multiple different cleavable joint group has been described.The mechanism that reagent breaks away from from these joint groups in cell comprises by disulfide bond reduction (as the United States Patent (USP) 4,489,710 of Spitler), irradiation is to the key (as the United States Patent (USP) 4,625,014 of Senter etc.) of photo-labile, the hydrolysis of derivative amino side chain (as the United States Patent (USP) 4,638,045 of Kohn etc.), the hydrolysis of serum complement mediation is (as the United States Patent (USP) 4 of Rodwell etc., 671,958), and acid-catalyzed hydrolysis (as the United States Patent (USP) 4 of Blattler etc., 569,789) and cracking.

Preferably with various medicaments and antibody coupling.In one embodiment, with a plurality of molecules and an antibody molecule coupling of medicament.In another embodiment, can be with medicament and antibody coupling of more than one types.Do not consider specific embodiment, can contain the immune conjugate of more than one medicaments with the several different methods preparation.For example, more than one medicaments can be directly and the antibody molecule coupling, maybe can use the joint that a plurality of connection site are provided.Alternatively, can use carrier.

Carrier can carry medicament with the whole bag of tricks, comprises directly or pass through the covalent bonding of joint group.Suitable carriers comprises albumen such as albumin (as the United States Patent (USP) 4,507,234 of Kato etc.), and peptide and polysaccharide be glycosaminoglycan (as the U.S. Patent number 4,699,784 of Shih etc.) for example.Carrier also can or be sealed by non-covalent bonding, for example wraps into lipid somatocyst interior (as United States Patent (USP) 4,429,008 and 4,873,088) and the carrying medicament.The small molecules and the chelate compound that the carrier of the radionuclide agent opposite sex are comprised radiohalogenization.For example, United States Patent (USP) 4,735,792 disclose the small molecules of representative radiohalogenization and synthetic.The radionuclide inner complex can by chelating comprise those contain nitrogen and sulphur atom as donor atom with the compound of bond or metal oxide, radionuclide and form.For example, the United States Patent (USP) 4,673,562 of Davison etc. discloses representational chelate compound and synthetic. The T cell composition

, provide aspect another in the present invention oncopeptide disclosed herein or its varient or the specific T cell of derivative.This cell can use standard step in external or prepared ex vivo usually.For example, can assign to separate the T cell, adopt commercial obtainable cellular segregation system, for example Isolex from the level of patient's marrow, peripheral blood or marrow or peripheral blood ^TMSystem, from Nexell Therapeutics, Inc. (Irvine, CA; Also see United States Patent (USP) 5,240,856; United States Patent (USP) 5,215,926; WO 89/06280; WO 91/16116 and WO 92/07243).Alternatively, the T cell can come autocorrelation or irrelevant people, non-human mammal, clone or culture.

Can stimulate the T cell with the polynucleotide of polypeptide, coded polypeptide and/or the antigen presenting cell (APC) of expressing this peptide species.This stimulation is carried out time enough being enough to allow to produce under the condition of the specific T cell to polypeptide of interest.Preferably, oncopeptide of the present invention or polynucleotide are present in the delivery vectors, as microsphere, are beneficial to specific T-cells and produce.

If T cell-specific propagation, secrete cytokines or kill the target cell of being wrapped up or expressing the gene of this polypeptide of coding by polypeptide thinks that the T cell is specific to polypeptide of the present invention.Can use the specificity of any estimation T cell in the multiple standards technology.For example, in chromium release assay or proliferation assay, compare with negative control, stimulation index shows the T cell-specific increase twice in dissolving and/or propagation more than.This mensuration can be as for example Chen etc., Cancer Res.54:1065-1070,1994 described carrying out.Alternatively, can finish with various known technologies the detection of T cell proliferation.For example, can detect T cell proliferation by measuring DNA synthesis rate increase (as by also measuring the tritium thymidine amount that contains that is incorporated among the DNA) with containing tritium thymidine pulse labelling T cell culture.Usually can make T cell proliferation increase twice at least in 3-7 days with oncopeptide (100ng/ml-100 μ g/ml, preferred 200ng/ml-25 μ g/ml) contact.Contact 2-3 hour as mentioned above and should cause the T cell activation, as use the standard cell lines factorial experiment to measure, wherein cytokine (as TNF or IFN-γ) emission levels increases twice and represents that the T cell activation (sees Coligan etc., Current Protocols in Immunology, vol.1, Wiley Interscience (Greene 1998)).The APC of oncopeptide, polynucleotide or express polypeptide produced reply and the activated T cell can be CD4 ⁺And/or CD8 ⁺Can use standard technique to expand to the specific T cell of oncopeptide.In preferred embodiments, the T cell is from patient, relevant donor or irrelevant donor, and stimulate and expand after give the patient.

For therapeutic purpose, can be in external or body will reply and the CD4 that breeds oncopeptide, polynucleotide or APC ⁺Or CD8 ⁺The T cell carries out quantity and expands.Can in all sorts of ways and finish this T cells in vitro propagation.For example, the T cell can contact oncopeptide again or corresponding to this immunogenicity of polypeptides small peptide partly, add or do not add T cell growth factor, the irritation cell of for example interleukin-2, and/or synthetic oncopeptide.Alternatively, can expand the quantity of one or more T cells of in the presence of oncopeptide, breeding by the clone.The method of clone cell is well known in the art, and comprises limiting dilution. Pharmaceutical composition

In other embodiments, the present invention relates to one or more polynucleotide disclosed herein, polypeptide, T cell and/or the preparation of antibody compositions in pharmaceutical acceptable carrier, make up separately or with one or more other form of therapy, be applied to cell or animal.

It should be understood that if expect composition disclosed herein also can carry out administration with other medicament combination, for example, other albumen or polypeptide or various pharmaceutically active agents.In fact, other composition that can comprise without limits is not as long as other medicament is to producing tangible detrimental action with contacting of target cell or host tissue.Therefore composition can send with required various other medicaments of particular case and pass.This composition can be from host cell or other biogenetic derivation purifying, or alternatively can be as chemosynthesis described here.Equally, this composition can further comprise replacement or derived RNA or DNA composition.

Therefore, in another aspect of the present invention, provide pharmaceutical composition, it comprises one or more polynucleotide described herein, polypeptide, antibody and/or T cell composition and physiology can be accepted carrier combinations.In some preferred embodiment, pharmaceutical composition of the present invention comprises immunogenicity polynucleotide of the present invention and/or peptide composition is used for preventative and therapeutic vaccine is used.Vaccine preparation for example M.F.Powell and M.J.Newman chief editor, is described among " Vaccine Design (the subunit and adjuvant approach), " Plenum Press (NY, 1995) usually.Usually, this composition will comprise one or more polynucleotide of the present invention and peptide composition and the combination of one or more immunostimulant.

Any pharmaceutical composition clearly described herein can comprise the pharmaceutically acceptable salt of polynucleotide of the present invention and polypeptide.This salt can be accepted nontoxic alkali from for example pharmacy, comprises that organic bases (as the salt of one-level, secondary and tertiary amine and basic aminoacids) and mineral alkali (as sodium, potassium, lithium, ammonium, calcium and magnesium salts) prepare.

In another embodiment, exemplary immunization originality composition of the present invention comprises the DNA of one or more polypeptide described herein of encoding as vaccine composition, makes polypeptide produce in position.As noted above, polynucleotide can give in multiple known to those of ordinary skills sent delivery system any.In fact, well known many gene delivery technology, Rolland Crit.Rev.Therap.Drug Carrier Systems 15:143-198 for example, 1998 describe and the reference that quote the there.Suitable polynucleotide expression system will be included in the essential regulating DNA regulating and controlling sequence (for example suitable promotor and termination signal) of expression among the patient certainly.Alternatively, the bacterium immunogenicity part sending delivery system to comprise to be applied in its cell surface expression polypeptide or the bacterium that secretes this epi-position (genus bacillus-Calmette-Guerrin) for example.

Therefore, in certain embodiments, use in the multiple known system in the mammalian cell any, that the polynucleotide importing of coding immunogenic polypeptide described herein is suitable and express based on virus.In the embodiment of an example, retrovirus provides convenience and effective platform for gene delivery system.Use technology known in the art, the nucleotide sequence of selected code book invention polypeptide can be inserted carrier and be packaged in the retroviral particle.Can and send and pass the experimenter the recombinant virus separation then.The retrovirus system of having described a large amount of examples is (as United States Patent (USP) 5,219,740; Miller and Rosman (1989) BioTechniques 7:980-990; Miller, A.D. (1990) Human GeneTherapy 1:5-14; Scarpa etc. (1991) Virology 180:849-852; Burns etc. (1993) Proc.Natl.Acad.Sci.USA 90:8033-8037; With Boris-Lawrie and Temin (1993) Cur.Opin.Genet.Develop.3:102-109).

The system based on adenovirus of a large amount of examples has also been described in addition.Different with the retrovirus in being incorporated into host genome, adenovirus is present in outside the karyomit(e) all the time, therefore makes the risk relevant with inserting mutagenesis reduce to minimum (Haj-Ahmad and Graham (1986) J.Virol.57:267-274; Bett etc. (1993) J.Virol.67:5911-5921; Mittereder etc. (1994) Human Gene Therapy 5:717-729; Seth etc. (1994) J.Virol.68:933-940; Barr etc. (1994) GeneTherapy 1:51-58; Berkner, K.L. (1988) BioTechniques 6:616-629; With (1993) Human Gene Therapy 4:461-476 such as Rich).

Various adeno associated viruss (AAV) carrier system has also developed to be used to send passs polynucleotide.Can make up the AAV carrier at an easy rate with technology well known in the art.As see United States Patent (USP) 5,173,414 and 5,139,941; International publication number WO 92/01070 and WO93/03769; Lebkowski etc. (1988) Molec.Cell.Biol.8:3988-3996; Vincent etc. (1990) Vaccines 90 (Cold Spring HarborLaboratory Press); Carter, B.J. (1992) Current Opinion inBiotechnology 3:533-539; Muzyczka, N. (1992) CurrentTopics in Microbiol.and Immunol.158:97-129; Kotin, R.M. (1994) Human Gene Therapy 5:793-801; Shelling and Smith (1994) Gene Therapy 1:165-169; With (1994) J.Exp.Med.179:1867-1875 such as Zhou.

Other can be used for sending the virus vector of the polynucleotide of passing code book invention polypeptide to comprise those virus from poxvirus family, for example vaccinia virus and avipoxvirus by transgenosis.For instance, vaccinia virus recombinant that can following construction expression recruit.At first the DNA with coded polypeptide is inserted in the appropriate carriers, makes its be close to cowpox promotor and flank cowpox dna sequence dna, as the sequence of coding thymidine kinase (TK).The cell that infects with cowpox simultaneously with this carrier transfection then.Homologous recombination is inserted into the gene of cowpox promotor and coding polypeptide of interest in the viral genome.By culturing cell in the presence of 5-bromouracil deoxyribose and select anti-its viral plaque, can select TK.sup. (-) recombinant chou of gained.

Can use infection/transfection system to provide one or more polypeptide described herein in the host cell of organism, to carry out derivable transient expression or coexpression easily based on cowpox.In this particular system, at first at vaccinia virus recombinant infection's cell of external use coding phage t7 RNA polymerase.This polysaccharase shows sharp susceptibility, and it only transcribes the template of carrying the T7 promotor.After the infection, with described polynucleotide or interested polynucleotide transfectional cell, by the T7 promoters driven.That expresses in tenuigenin is transcribed into RNA from the polysaccharase of vaccinia virus recombinant with the DNA of transfection, is translated as polypeptide by host's body translation then.This method provides the high level of a large amount of RNA and translation product thereof, instantaneous, the generation in tenuigenin.As see Elroy-Stein and Moss, Proc.Natl.Acad.Sci.USA (1990) 87:6743-6747; Proc.Natl.Acad.Sci.USA such as Fuerst (1986) 83:8122-8126.

Alternatively, fowlpox virus, for example chicken pox and yellowbird poxvirus also can be used to send and pass interested encoding sequence.Known expression is from the immunogenic recombinant fowlpox virus of Mammals pathogenic agent, when giving non-bird species, can provide protective immunity.It is desirable especially that the fowl pox carrier is used for people and other mammalian species, can only produce in susceptible bird kind and duplicate because fowl pox belongs to the member, therefore do not have infectivity in mammalian cell.The method that produces recombinant fowlpox virus is known in the art and utilizes gene recombination, the generation of relevant vaccinia virus as mentioned above.As see WO 91/12882; WO 89/03429 and WO 92/03545.

Also can use in a large amount of Alphavirus carriers any one to send and pass polynucleotide compositions of the present invention, for example in United States Patent (USP) 5,843,723; 6,015,686; Those carriers of describing in 6,008,035 and 6,015,694.Also can use some carrier based on Venezuela's type equine encephalitis virus (VEE), the example can be at United States Patent (USP) 5,505, finds in 947 and 5,643,576.

In addition, molecule is puted together carrier, for example the adenovirus chimeric vector of describing among Proc.Natl.Acad.Sci.USA (1992) 89:6099-6103 such as J.Biol.Chem. (1993) 268:6866-6869 such as Michael and Wagner also can be used for the gene delivery under the present invention.

Find Fisher-Hoch etc. for example, Proc.Natl.Acad.Sci.USA 86:317-321,1989 in can offering hereinafter about these and other known other descriptive information that send delivery system based on virus; Flexner etc., Ann.N.Y.Acad.Sci569:86-103,1989; Flexner etc., Vaccine 8:17-21,1990; United States Patent (USP) 4,603,112,4,769,330 and 5,017,487; WO 89/01973; United States Patent (USP) 4,777,127; GB 2,200, and 651; EP 0,345, and 242; WO91/02805; Berkner, Biotechniques 6:616-627,1988; Rosenfeld etc., Science 252:431-434,1991; Kolls etc., Proc.Natl.Acad.Sci.USA 91:215-219,1994; Kass-Eisler etc., Proc.Natl.Acad.Sci.USA 90:11498-11502,1993; Guzman etc., Circulation 88:2838-2848,1993; With Guzman etc., Cir.Res.73:1202-1207,1993.

In certain embodiments, polynucleotide can be incorporated in the genome of target cell.This integration can occur in specific position and direction by homologous recombination (gene substitution), or can at random, non-specific position (gene increase) integrate.In other embodiment, polynucleotide can be used as that independent dissociative DNA fragment is stable to remain in the cell.The sequence of this polynucleotide passage or " episome " coding be enough to allow to be independent of the host cell cycle or with the Maintenance and Replication of host cell cycle synchronisation.Expression construct is sent to pass to the pattern of cell and polynucleotide and is retained in the type that the expression construct of use is depended in position in the cell.

In another embodiment of the invention, polynucleotide are used/are sent and pass as " exposing " DNA, Ulmer etc. for example, Science 259:1745-1749,1993 described and Cohen, Science 259:1691-1692,1993 summary.DNA is wrapped the picked-up that can increase naked DNA on the biodegradable pearl that is gone into cell to effective transhipment.

In another embodiment, can send by the particle bombardment method and pass composition of the present invention, wherein many existing descriptions.In the example of an explanation, the sub-acceleration of gas drive kinetochore can be with (Oxford is UK) with Powderject Vacciries Inc. (Madison as Powderject Pharmaceuticals PLC, WI) those devices of Zhi Zaoing are finished, the some of them example is in United States Patent (USP) 5,846,796; 6,010,478,5,865,796; 5,584,807; With description in the European patent 0500799.This method provides needleless to send the method for passing, the dry powder doses of micro-particle wherein, and for example polynucleotide or polypeptide particle accelerate in the helium flow that is produced by hand gear at a high speed, promote particle and enter interested target tissue.

In relevant embodiment, other apparatus and method that can effectively carry out the gas-powered Needleless injection present composition comprise Bioject, and (the some of them example is in United States Patent (USP) 4,790,824 for Portland, OR) those that provide for Inc.; 5,064,413; 5,312,335; 5,383,851; 5,399,163; Describe in 5,520,639 and 5,993,412.

According to another embodiment, pharmaceutical composition described herein also will comprise one or more immunostimulant except comprising immunogenicity polynucleotide of the present invention, polypeptide, antibody, T cell and/or APC composition.Immunostimulant is meant any basically enhancing or strengthens material to the antigenic immunne response of external source (antibody and/or cell-mediated).A kind of immunostimulant of preferred type comprises adjuvant.Many adjuvants contain and are designed to protect antigen that quick catabolic material does not take place, for example aluminium hydroxide or mineral oil and immunne response stimulant, for example lipid A, from the albumen of Bordetella pertussis or mycobacterium tuberculosis.Some adjuvant is commercial available, for example Freund's incomplete adjuvant and Freund's complete adjuvant (DifcoLaboratories, Detroit, MI); The Merck adjuvant 65 (Merck and Company, Inc., Rahway, NJ); AS-2 (SmithKline Beecham, Philadelphia, PA); Aluminium salt is aluminum hydroxide gel (alum) or aluminum phosphate for example; Calcium, iron or zinc salt; The insoluble suspension of acidylate tyrosine; Acidylate sugar; Positively charged ion or anionic derivative polysaccharide; Polyphosphonitrile; Biodegradable microsphere; Monophosphoryl lipid A and quil A.Cytokine, for example GM-CSF, interleukin-2 ,-7 ,-12 and other similar somatomedin also can be used as adjuvant.

In certain embodiments of the present invention, the preferred adjuvant composition is mainly induced Th1 type immunne response.High level Th1 cytokines (as IFN-γ, TNF α, IL-2 and IL-12) tends to induce the cell-mediated immune responses at institute's administration of antigens.In contrast to this, high-level Th2 cytokines (as IL-4, IL-5, IL-6 and IL-10) tends to induce humoral immunoresponse(HI).Use as behind the vaccine that provides here, the patient will support to comprise the immunne response that Th1 and Th2 type are replied.In preferred embodiments, wherein mainly be replying of Th1 type, the level of Th1 cytokines will be increased to the degree than the higher level of Th2 cytokines.Use standard test to be easy to estimate the level of these cytokines.The summary of cytokine family is seen Mosmann and Coffman, Ann.Rev.Immunol.7:145-173,1989.

Some adjuvant that causes mainly that preferably the Th1 type is replied comprises for example monophosphoryl lipid A, preferred 3-takes off-and the combination of O-acyl monophosphoryl lipid A and aluminium salt.MPL ^_Adjuvant can obtain (Seattle, WA from Corixa company; For example see United States Patent (USP) 4,436,727; 4,877,611; 4,866,034 and 4,912,094).The oligonucleotide (wherein CpG dinucleotides right and wrong are methylated) that contains CpG also mainly induces Th1 to reply.This oligonucleotide be know and at for example WO 96/02555, describe in WO 99/33488 and the United States Patent (USP) 6,008,200 and 5,856,462.The immunostimulating dna sequence dna is also at for example Sato etc., and Science273:352 describes in 1996.Another kind of preferred adjuvants comprises saponin, QuilA for example, or derivatives thereof, comprise QS21 and QS7 (Aquila BiopharmaceuticalsInc., Framingham, MA); Aescine; Digitin; Or Gypsophila or Chenopodium quinoa saponin.Other preferred formulation comprises more than one saponin in adjunvant composition of the present invention, the combination of at least two kinds of following saponins: QS21 for example, QS7, Quil A, β-Aescine or digitin.

Alternatively, saponin preparation can make up with vaccine carrier, described vaccine carrier comprises chitosan or other polycationic polymer, polylactide and polylactide-altogether-glycollide particulate, based on the polymeric matrix of poly-N acetylglucosamine, the particulate that comprises the polysaccharide of polysaccharide or chemically modified, liposome and based on the particulate of lipid comprises the particulate of monoglyceride etc.Saponin also can be prepared in the presence of cholesterol to form microgranular texture such as liposome or ISCOMs.In addition, saponin can be prepared jointly with Soxylat A 25-7 or ester, in non-particulate solution or suspension, or microgranular texture as few layer liposome or ISCOM in.Saponin also can with vehicle Carbopol for example ^RCommon preparation with increase viscosity, or can be mixed with dry powder form jointly with powdery vehicle such as lactose.

In a preferred embodiment, adjuvant system comprises the combination of monophosphoryl lipid A and saponin derivative, for example QS21 and 3D-MPL ^_The adjuvant combination, as described in WO 94/00153, or the lower composition of reactionogenicity, wherein QS21 cholesterol cancellation is as described in WO 96/33739.Other preferred preparation comprises O/w emulsion and tocopherol.QS21, the 3D-MPL of another particularly preferred use in O/w emulsion described among the WO 95/17210 ^_The adjuvant formulation of adjuvant and tocopherol.

Another strengthens adjuvant system and comprises that being combined among the WO 00/09159 of the combination that contains CpG oligonucleotide and saponin derivative, particularly CpG and QS21 is open.Preferred formulation comprises O/w emulsion and tocopherol in addition.

The example adjuvant that is used in the pharmaceutical composition of the present invention in addition comprises MontanideISA 720 (Seppic, France), SAF (Chiron, California, the U.S.), ISCOMS (CSL), MF-59 (Chiron), SBAS adjuvant series is (as SBAS-2 or SBAS-4, can be from SmithKline Beecham, Rixensart, Belgium obtains), Detox (Enhanzyn ^_) (Corixa, Hamilton, MT), RC-529 (Corixa, Hamilton, MT) and other aminoalkyl glucosaminide 4-phosphoric acid salt (AGPs), those that in the U.S. Patent Application Serial 08/853,826 and 09/074,720 of pending trial, describe for example, it is open introduces here as a reference with its complete form, and Soxylat A 25-7 adjuvant those as describing in WO 99/52549A1.

Other preferred adjuvant comprises general formula (I): HO (CH ₂CH ₂O) _nThe adjuvant molecule of-A-R, wherein n is 1-50, A be a key or-C (O)-, R is C _1-50Alkyl or phenyl C _1-50Alkyl.

One embodiment of the invention are made up of the vaccine preparation of the Soxylat A 25-7 that comprises general formula (I), wherein n between 1 and 50, preferred 4-24, most preferably 9; R is C _1-50, preferred C ₄-C ₂₀Alkyl and C most preferably ₁₂Alkyl, A are keys.The concentration of Soxylat A 25-7 should be in the scope of 0.1-20%, and preferred 0.1-10% is most preferably in the scope of 0.1-1%.Preferred Soxylat A 25-7 is selected from down group: polyoxyethylene-9-lauryl ether, polyoxyethylene-9-stearyl ether, polyoxyethylene-8-stearyl ether, polyoxyethylene-4-lauryl ether, polyoxyethylene-35-lauryl ether and polyoxyethylene-23-lauryl ether.Merck index (12 ^ThVersion; For example polyoxyethylene laurel ether of Soxylat A 25-7 has been described entry 7717).These adjuvant molecules have been described among the WO 99/52549.

If expectation, according to the Soxylat A 25-7 of top general formula (I) can with another kind of adjuvant combination.For example, the preferred adjuvants combination preferably contains the described CpG just like the UK Patent Application GB9820956.2 of pending trial.

According to another embodiment of the invention, immunogenic composition described herein send as dendritic cell, scavenger cell, B cell, monocyte and other cell that can be transformed into effective APCs by antigen presenting cell (APCs) and passs the host.This cell can but be not must be by genetic modification increasing the ability of antigen-presenting, improving activation and/or to keep t cell response, with itself have antitumous effect and/or with recipient's immune-compatible (the HLA haplotype that promptly matches).APCs can separate from multiple biological fluid and organ any usually, comprises the other tissue of tumour and tumour, and can be from body, allochthonous, isogenic or heterogenic cell.

Some preferred embodiment of the present invention uses dendritic cell or its progenitor cell as antigen presenting cell.Dendritic cell are very effective APCs (Banchereau and Steinman, Nature 392:245-251,1998) and show and effectively to cause preventative or therapeutic anti-tumour immune (seeing Timmerman and Levy, Ann.Rev.Med 50:507-529,1999) as the physiology adjuvant.Usually, dendritic cell can be based on its typical proterties (being starlike, in the external tangible tenuigenin projection (dendron) of seeing) in position, and it efficiently absorbs, the ability of processing and antigen-presenting and activate the ability of inmature t cell response and identify.Certainly transform dendritic cell expressing usually in vivo or undiscovered specific cell surface receptor or part in the stripped dendritic cell, and the dendritic cell of this modification comprise in the present invention.As the refill of dendritic cell, in vaccine, can use the carrying secretion antigenic dendritic cell of vesica (being called exosome) (seeing Zitvogel etc., Nature Med.4:594-600,1998).

Dendritic cell and progenitor cell can obtain from peripheral blood, marrow, tumor-infiltrated cell, other tumor tissues infiltration cell, lymphoglandula, spleen, skin, Cord blood or other suitable tissue or liquid.For example, by the combination to adding cytokine such as GM-CSF, IL-4, IL-13 and/or TNF α from the monocyte cultures of peripheral blood results, dendritic cell can ex vivo differentiation.Alternatively, by other combination of compounds that adds GM-CSF, IL-3, TNF α, CD40 part, LPS, flt3 part and/or induce dendritic cell differentiation, maturation and breed in substratum, the CD34 positive cell of gathering in the crops from peripheral blood, Cord blood or marrow can be divided into dendritic cell.

Dendritic cell are divided into " prematurity " and " maturation " cell easily, and it provides distinguishes two kinds and characterize the clearly simple method of phenotype.Yet this name should not be interpreted as getting rid of all possible differentiation intermediate stage.The prematurity dendritic cell are characterized by antigen uptake and the high APC of working ability, and it is relevant with the mannose receptor high expression level with Fc γ acceptor.The typical feature of ripe phenotype is that these sign expression are low, but is responsible for the cell surface molecule of T cell activation such as the expression height of I class and II class MHC, adhesion molecule (as CD54 and CD11) and costimulatory molecules (as CD40, CD80, CD86 and 4-1BB).

Usually can make encoded polypeptides or its immunogenicity part at cell surface expression with polynucleotide of the present invention (or its part or other varient) transfection APCs.This transfection can take place in external, and the pharmaceutical composition that comprises this transfectional cell then can be used for the treatment of purpose, as described here.Alternatively, the gene delivery carrier that is oriented to dendritic cell or other antigen presenting cell can be applied to the patient, causes esoteric transfection.Usually can use for example any method known in the art to carry out in the body and stripped transfection dendritic cell, the method of describing among the WO 97/24447 for example, or Mahvi etc., Immunology and cellBiology 75:456-460, the 1997 particle gun methods of describing.Dendritic cell carryings antigen can by with dendritic cell or progenitor cell with oncopeptide, DNA (exposed or in plasmid vector) or RNA incubation; Or finish with the recombinant bacteria of antigen expressed or the common incubation of virus (as cowpox, fowl pox, adenovirus or lentiviral vectors).Before the carrying, polypeptide can with immune mating partner (as the carrier molecule) covalent attachment that t helper cell is provided.Alternatively, can be separately or in the presence of polypeptide, with unconjugated immune mating partner dendritic cell are carried out pulse.

Although any suitable carrier known to those of ordinary skills can be used for pharmaceutical composition of the present invention, bearer type can depend on administering mode and difference usually.Composition of the present invention can be prepared and be used for any suitable administering mode, for example comprises, local, oral, nose, mucous membrane, intravenously, encephalic, intraperitoneal, subcutaneous and intramuscular administration.

The carrier that is used for this pharmaceutical composition is a biocompatibility, and can also be biodegradable.In certain embodiments, preferred formulation provides the activeconstituents emission levels constant relatively.Yet, in other embodiments, may expect to take place immediately to discharge faster after the administration.Being formulated in the level that those of ordinary skills use known technology of this composition.The effective example carrier of this respect comprises poly-(lactide-co-glycolide) particulate, polyacrylic ester, latex, starch, Mierocrystalline cellulose, dextran or the like.The carrier that the delay of other example discharges comprises the supramolecule bio-carrier, it comprise the hydrophilic core of on-liquid (as cross-linked polysaccharides or oligose) and, the optional skin that comprises amphipathic compound such as phosphatide is (as seeing United States Patent (USP) 5,151,254 and PCT application WO 94/20078, WO/94/23701 and WO96/06638).The amount of contained active compound depends on the time length and the character to be treated or the prevention illness of position, release rate and the expectation of implantation in sustained release preparation.

In the embodiment of another example, use the carrier of biodegradable microsphere (as the polylactic acid poly glycolate) as the present composition.Suitable biodegradable microsphere is at for example United States Patent (USP) 4,897,268; 5,075,109; 5,928,647; 5,811,128; 5,820,883; 5,853,763; Open in 5,814,344,5,407,609 and 5,942,252.Improved HBc protein carrier system, for example described in the document that quote WO/99 40934 and there, also will be in many application effectively.Another example carrier/send the system of passing to use the carrier that comprises the granule protein complex body, for example United States Patent (USP) 5,928, those described in 647, it can induce I class restrictive cell toxic T lymphocyte to reply in the host.

Pharmaceutical composition of the present invention will further comprise one or more damping fluids (as neutral buffered saline or phosphate-buffered saline), carbohydrate (as glucose, seminose, sucrose or dextran), N.F,USP MANNITOL, albumen, polypeptide or amino acid such as glycine, antioxidant, fungistat, sequestrant such as EDTA or gsh, adjuvant (as aluminium hydroxide) usually, make preparation and acceptor blood etc. ooze, hypotonic or weak height oozes solute, suspension agent, thickening material and/or sanitas.Alternatively, composition of the present invention can be mixed with the lyophilize thing.

Pharmaceutical composition described herein may reside in unitary dose or the multi-dose container, for example Mi Feng ampoule or bottle.The sterility of the packaged type maintenance preparation of common this container and stability are when using.Usually, preparation can be preserved with the suspension agent in oily or the aqueous carrier, solution or emulsion form.Alternatively, pharmaceutical composition can be preserved under the lyophilize condition that only need add sterile liquid carrier before use immediately.

The suitable dose and the treatment plan of particular composition described herein used in exploitation in various treatment plans, comprise as in oral, parenteral, intravenously, the nose and intramuscular administration and preparation, be well known in the art, concise and to the point below some that discuss are wherein made the general remark purpose.

In some applications, pharmaceutical composition disclosed herein can pass through the orally give animal.For this reason, these compositions can be prepared jointly with the non-activity thinner or with assimilating edible carrier, or they can wrap in duricrust or the soft shell gelatin capsules, or they can be pressed into tablet, or they can directly mix in the meals food.

Active compound even can use with the vehicle fusion and can take in tablet, buccal tablet, lozenge, capsule, elixir, suspension agent, syrup, wafer or the like form and (see Mathiowitz etc. for example, Nature 1997 Mar 27; 386 (6623): 410-4; Crit Rev Ther Drug Carrier Syst 1998 such as Hwang; 15 (3): 243-84; United States Patent (USP) 5,641,515; United States Patent (USP) 5,580,579 and United States Patent (USP) 5,792,451).Tablet, lozenge, pill, capsule or the like also can contain any composition in the multiple other composition, for example, can add tackiness agent, as tragacanth gum, gum arabic, W-Gum or gelatin; Vehicle is as Lin Suanergai; Disintegrating agent is as W-Gum, yam starch, alginic acid or the like; Lubricant is as Magnesium Stearate; And sweeting agent, as sucrose, lactose or asccharin, or seasonings, as peppermint, wintergreen oil or cherry seasonings.When dosage unit form was capsule, except the material of the above-mentioned type, it can also contain liquid vehicle.Can there be the physical form of various other materials as dressing or improvement dose unit.For example, tablet, pill or capsule can be used lac, sugar or the two dressing.Certainly, any material that is used to prepare any dosage unit form should be that the pure and employed amount of pharmacy is nontoxic substantially.In addition, active compound can mix in the sustained release preparation.

Typically, these preparations contain about at least 0.1% active compound or more, although Zong the per-cent of activeconstituents certainly changes and can be easily weight of formulation or volume about 1 or 2% to about 60% 70% or higher between.Nature can prepare in every kind of treatment compositions useful the amount of active compound and make in any given unitary dose compound and can obtain proper dosage.As solubleness, bioavailability, biological half-life, route of administration, shelf life of products, and other pharmacy Consideration will be that the technician who prepares this field of pharmaceutical preparations can expect desirable thus multiple dosage and treatment plan.

For oral, composition of the present invention can optionally be the form of mouth wash shua, toothpaste, buccal tablet, mouth spray or hypogloeeis oral preparations with one or more vehicle fusion.Alternatively, activeconstituents can mix in the oral liquid, as the solution of boronic acid containing sodium, glycerine and saleratus, or be dispersed in the toothpaste, or with the treatment significant quantity join in the composition, composition can comprise water, tackiness agent, abrasive, seasonings, whipping agent and wetting agent.Alternatively, composition can form and can place the hypogloeeis or in orally-dissolvable tablet or solution form.

In some cases, can expect parenteral, intravenously, intramuscular or even intraperitoneal send and pass pharmaceutical composition disclosed herein.This method is well known to those skilled in the art, and some of them are further at for example United States Patent (USP) 5,543,158; United States Patent (USP) 5,641,515 and United States Patent (USP) 5,399,363 in describe.In certain embodiments, can be in water suitable mixed surfactant, usually prepare solution as hydroxy propyl cellulose as the active compound of free alkali or pharmaceutically acceptable salt.Also can in glycerine, liquid polyethylene glycol and its mixture and oil, prepare dispersion agent.Under common preservation and working conditions, these preparations will contain sanitas usually to prevent microorganism growth.

The example medicament forms that is fit to the injection use comprises the sterile powder (for example, seeing United States Patent (USP) 5,466,468) of aseptic aqueous solution or dispersion agent and interim preparation aseptic injectable solution or dispersion agent.In all cases, used form must aseptic and mobile must be able to the injection easily.Under manufacturing and preservation condition, it must be stablized and must keep the effect of opposing microbiological contamination, as bacterium and fungi.Carrier can be to contain for example water, ethanol, polyvalent alcohol (as glycerine, propylene glycol and liquid polyethylene glycol or the like), its suitable mixture, and/or the solvent of vegetables oil or dispersion medium.Can be for example by using dressing such as Yelkin TTS, under the situation of dispersion agent by keeping required particle size and/or by using tensio-active agent to keep suitable flowability.Various antiseptic-germicides and anti-mycotic agent, for example parabens, butylene-chlorohydrin, phenol, Sorbic Acid, Thiomersalate or the like can be beneficial to and prevent microbial process.In many cases, will preferably include isotonic agent, for example sugar or sodium-chlor.Use in the composition and postpone the absorption delay that absorption agent can make injectable composition, for example monostearate aluminium and gelatin.

In one embodiment, for carrying out parenteral admin with the aqueous solution, if desired, solution should suitably cushion, and at first makes liquid diluent etc. ooze with enough salt solution or glucose.These specific aqueous solution are particularly suitable for intravenously, intramuscular, subcutaneous and intraperitoneal administration.Relevant therewith, according to of the present invention open, one skilled in the art will know that spendable sterile aqueous media.For example, dosage can be dissolved in 1ml etc. and ooze and add 1000ml h inf liquid in the NaCl solution or in plan input position injection, (for example seeing " Remington ' s Pharmaceutical Sciences " 15 editions, 1035-1038 page or leaf and 1570-1580 page or leaf).According to the experimenter's who is treated situation, will do necessary change to dosage.In addition, use for human body, preparation will preferably satisfy sterility, pyrogen and Generally Recognized as safe and the purity rubric that FDA biological standard office requires certainly.

In another embodiment of the invention, composition disclosed herein can be mixed with neutrality or salt form.The pharmaceutically acceptable salt of example comprise acid salt (forming) with proteic free amine group and with the formed salt of mineral acid, mineral acid example hydrochloric acid or phosphoric acid, or the salt that forms with organic acid such as acetic acid, oxalic acid, tartrate, tussol or the like.The salt that forms with free carboxy also can be from mineral alkali, for example, and sodium, potassium, ammonium, calcium or ferric oxyhydroxide and organic bases such as Isopropylamine, Trimethylamine 99, Histidine, PROCAINE HCL, PHARMA GRADE or the like.After the preparation, solution will carry out administration with mode compatible with dosage particles and treatment significant quantity.

Carrier can further comprise any and all solvents, dispersion medium, carrier, dressing, thinner, antiseptic-germicide and anti-mycotic agent, isotonic agent and absorption delay agent, damping fluid, carrier soln, suspension agent, colloid or the like.Thisly be used for the medium of pharmaceutically active substance and the use of reagent is well known in the art.Except with inconsistent any conventional media of activeconstituents or reagent, can estimate its use in therapeutic composition.Additional activeconstituents also can be incorporated in the composition.Phrase " pharmacy can be accepted " is meant when being applied to human body, does not produce the molecular entity and the composition of irritated or similar adverse effect.

In certain embodiments, can send the drug delivery composition by nose internal spraying, suction and/or other aerosol delivery vectors.Described by the nose arosol spray and directly sent the method for passing to lung with gene, nucleic acid and peptide combinations, for example, at United States Patent (USP) 5,756,353 and United States Patent (USP) 5,804,212 in.Similarly, use finely divided resin (Takenaga etc., JControlled Release 1998 Mar 2 in the nose; 52 (1-2): 81-7) sending drug delivery with lysophosphatidyl glycerol compound (United States Patent (USP) 5,725,871) also is that pharmaceutical field is known.Similarly, United States Patent (USP) 5,780,045 has described striding mucous membrane with tetrafluoroethylene supported matrix form and sending drug delivery of example.

In certain embodiments, use liposome, microcapsule, particulate, lipid particles, vesica or the like that composition of the present invention is imported proper host cell/organism.Particularly, composition of the present invention can be mixed with and wrap into lipid particles, liposome, vesica, microsphere or microparticle or the like and send and pass.Alternatively, composition of the present invention can covalently or non-covalently be bonded to this carrier surface.

Liposome and liposome sample preparation are that those skilled in the art (for example see Lasic, Trends Biotechnol 1998Jul known to usually as the formation of active drug carrier and use; 16 (7): 307-21; Takakura, Nippon Rinsho 1998 Mar; 56 (3): 691-5; Chandran etc., Indian J Exp Biol.1997 Aug; 35 (8): 801-9; Margalit, Crit Rev Ther Drug Carrier Syst.1995; 12 (2-3): 233-61; United States Patent (USP) 5,567,434; United States Patent (USP) 5,552,157; United States Patent (USP) 5,565,213; United States Patent (USP) 5,738,868 and United States Patent (USP) 5,795,587, introduce here as a reference so that its complete form is special for every piece).

Liposome successfully has been used for being difficult to usually the many cell types with other method transfection, comprises the T cell suspension, primary hepatocyte culture and PC12 cell (Renneisen etc., J.Biol Chem.1990 Sep 25; 265 (27): 16337-42; Muller etc., DNA Cell Biol.1990 Apr; 9 (3): 221-9).In addition, liposome is not subjected to the restriction of DNA length, and the latter is typical feature for the delivery system that send based on virus.Liposome has been effective to gene, various medicine, radiotherapy dose, enzyme, virus, transcription factor, allosteric effector etc. are imported in multiple culturing cell system and the animal.In addition, use liposome to send and pass back as if do not occur together autoimmune response or unacceptable toxicity at whole body.

In certain embodiments, liposome is by phospholipid form that is scattered in water-bearing media and the automatic double-deck vesica (term is also referred to as multilamellar vesicle (MLVs)) of multilayer concentric that forms.

Alternatively, in other embodiments, the pharmacy that the invention provides the present composition can be accepted microcapsule formulation.Microcapsule usually can with stable and repeatably mode wrap into compound and (see Quintanar-Guerrero etc. for example, Drug Dev Ind Pharm.1998 Dec; 24 (12): 1113-28).For fear of because the side effect that cell interpolymer overload causes, can use can degradation in vivo this ultrafine particulate of polymer design (the about 0.1 μ m of size).This particulate can be as for example Couvreur etc., Crit RevTher Drug Carrier Syst.1988; 5 (1): 1-20; Zur Muhlen etc., Eur J Pharm Biopharm.1998 Mar; 45 (2): 149-55; J Controlled Release.1998 Jan 2 such as Zambaux; 50 (1-3): 31-40; With United States Patent (USP) 5,145,684 described preparations. Cancer treatment method

The present invention further aspect, pharmaceutical composition described herein can be used for the treatment of cancer, especially for the immunotherapy of lung cancer.In this method, pharmaceutical composition described herein is applied to the patient, be typically warm-blooded animal, preferably the people.The patient can suffer from or not suffer from cancer.Therefore, top pharmaceutical composition can be used for the patient that preventing cancer takes place or cancer is suffered from treatment.Pharmaceutical composition and vaccine can the exenterate primary tumo(u)r and/or give radiotherapy for example or the treatment of conventional chemotherapy medicine before or after give.As discussed above, can be with any suitable method drug administration composition, comprise in intravenously, intraperitoneal, intramuscular, subcutaneous, the nose, intradermal, anus, vagina, part and oral administration.

In certain embodiments, immunotherapy can be an active immunity treatment, and wherein treatment depends on and gives in vivo to stimulate endogenous host immune system to take place antineoplastic reaction behind the immunne response improving agent (polypeptide that for example provides and polynucleotide) here.

In other embodiments, immunotherapy can be a passive immunotherapy, and wherein treatment comprises sending to pass and can directly or indirectly mediate anti-tumour effect and needn't rely on the active reagent of the definite tumour immunity of having of complete host immune system (for example effector cell or antibody).Effector cell's example comprises T cell as discussed above, T lymphocyte (CD8 for example ⁺Cytotoxic T lymphocyte and CD4 ⁺T assists tumor infiltrating lymphocyte), killer cell (as natural killer cell and lymphokine activated killer cell), the antigen presenting cell (as dendritic cell and scavenger cell) of the polypeptide that B cell and expression provide here.To the TXi Baoshouti of the polypeptid specificity quoted here and antigen receptor can be by the clone, express and transfer to and carry out adoptive immunotherapy among other carrier or the effector cell.Here the polypeptide that provides also can be used to produce antibody or antiidiotypic antibody (as mentioned above with at United States Patent (USP) 4,918,164 in) and carry out passive immunotherapy.

Be used for adoptive immunotherapy as the effector cell that can obtain sufficient amount usually described here by growth in vitro.With single antigen-specific effector cell quantity extend to tens and the culture condition of retention body endoantigen identification be well known in the art.This condition of in vitro culture typically uses usually in cytokine (as IL-2) and does not divide and use the antigen discrete stimulus in the presence of the feeder cell.As noted above, in order to produce the cell of the sufficient amount that is used for immunotherapy, can be with the immuno active polypeptide rapid expansion T cells with antigenic specificity culture that provides here.Particularly, can use standard technique well known in the art, to antigen presenting cell, for example dendritic cell, scavenger cell, monocyte, inoblast and/or B cell carry out pulse or carry out transfection with one or more polynucleotide with immuno active polypeptide.For example, available have a polynucleotide transfection antigen presenting cell that is fit to be increased in expression promoter in recombinant virus or other expression system.The effector cell of the cultivation that is used for the treatment of must be able to grow and extensively distribution and long-term surviving in vivo.Research shown can inducing culture with the antigen repetitive stimulation that replenishes IL-2 the effector cell grow in vivo and with considerable quantity long-term surviving (seeing Cheever etc. for example, Immunological Reviews 157:177,1997).

Alternatively, the carrier of expressing the polypeptide quote here can import the antigen presenting cell of taking from the patient and the clonal propagation that exsomatizes to plant back to same patient.Can use any means known in the art that transfectional cell is imported the patient once more, preferably with sterile form by in intravenously, the chamber, use in intraperitoneal or the tumour.

The route of administration of therapeutic composition described herein and frequency, and dosage will be different between individuality and individuality, use standard technique can be easy to determine.Usually, can be by (as by sucking) or orally give pharmaceutical composition and vaccine in injection (as intracutaneous, intramuscular, intravenously or subcutaneous), the nose.Preferably, in 52 weeks, can give 1 to 10 dosage.Preferably give 6 dosage, can periodically give booster immunization thereafter with 1 month interval.The alternative scheme may be fit to individual patient.Proper dosage is after giving as mentioned above, and the amount of compound can promote anti-tumor immune response, and at least at baseline (i.e. not treatment) the above 10-50% of level.Can be by measuring patient's anti-tumour antibody or monitoring this reaction by producing in external vaccine dependency of killing the cytolysis effector cell of patient tumors cell.Do not compare with inoculating the patient, the inoculation the patient in this vaccine should also can cause make clinical effectiveness improve (as more frequent alleviation, wholly or in part or the longer time anosis survival) immunne response.Usually, for pharmaceutical composition that contains one or more polypeptide and vaccine, the weight range of the every peptide species that exists in the dosage is from the about 25 μ g to 5mg of per kilogram host.The big young pathbreaker of proper dosage is with patient's size variation, but typical scope is from the extremely about 5mL of 0.1mL.

Usually, suitable dosage and treatment plan amount that active compound is provided enough provides and treats and/or prevents income.This reaction can compare with untreated patient by the patient of treatment determine clinical effectiveness improve (as more frequent alleviation, wholly or in part or the anosis survival of longer time) monitor.Increase to the immunne response of the preexist of oncoprotein is relevant with the clinical effectiveness improvement usually.Usually can use propagation, cytotoxicity or the cytokine assay of standard to estimate this immunne response, described mensuration can use the sample that derives from the patient treatment front and back to implement. Cancer detection and diagnosis composition, method and test kit

Usually, can be based on existing one or more lung tumor proteins and/or this proteic polynucleotide of encoding in the patient, to detect cancer in the biological specimen that derives from the patient (for example, blood, serum, phlegm, urine and/or tumor biopsy).In other words, this albumen can exist or non-existent sign as indication cancer such as lung cancer.In addition, this albumen can be used for detecting other cancer.Here the wedding agent that provides allows in the detection of biological sample and wedding agent bonded antigen levels usually.Polynucleotide primer and probe can be used to detect the proteic mRNA level of codes for tumor, and it also is that cancer exists or non-existent sign.Usually, the lung tumor sequence should be to exist to be higher than healthy tissues triple level at least in tumor tissues.

There are various mensuration forms known to multiple those of ordinary skills to use wedding agent to detect polypeptide sign in the sample.As see Harlow and Lane, Antibodies:ALaboratory Manual, Cold Spring Harbor Laboratory, 1988.Usually, can be by (a) feasible biological specimen contact wedding agent from the patient; (b) detect in the sample and wedding agent bonded polypeptide level; (c) polypeptide level and predetermined cutoff value are compared to determine that there is or does not exist cancer in the patient.

In preferred embodiments, mensuration comprises that the wedding agent that use is fixed on the solid support separates in conjunction with polypeptide and with all the other compositions of sample.Then can be with containing the reporter gene group and combining polypeptide with wedding agent/complex of polypeptides specificity bonded detection reagent detection.This detection reagent can comprise, for example, with polypeptid specificity bonded wedding agent or antibody or with other material of wedding agent specificity bonded, as anti-immunoglobulin, Protein G, albumin A or lectin.Alternatively, can adopt competitive assay, wherein use the reporter group labeling polypeptide and behind wedding agent and sample incubation, make polypeptide in conjunction with the fixed wedding agent.The sample composition suppresses the reactivity of polypeptide and the wedding agent bonded degree indication sample and the fixed wedding agent of mark.The polypeptide that is suitable for this mensuration comprises total length lung tumor protein and it and wedding agent bonded polypeptide portion, as mentioned above.

Solid support can be any material that the oncoprotein known to those of ordinary skills can adhere to.For example, solid support can be detection hole or nitrocellulose filter or other suitable membrane in the microtiter plate.Alternatively, this support can be pearl or dish, for example glass, glass fibre, latex or plastic material, for example polystyrene or polyvinyl chloride.Support also can be magnetic-particle or fiber optic transmitter, for example at United States Patent (USP) 5,359, and those disclosed in 681.Can use various technology well known by persons skilled in the art that wedding agent is fixed on the solid support, described method is fully described in patent and scientific and technical literature.In content of the present invention, term " is fixed " and is meant non-covalent combination as absorption, with covalent attachment (can be reagent with direct between functional group on the support be connected maybe can be that method by cross-linking reagent connects).Preferably be adsorbed in fixing in the hole of titer plate or on the film.In this case, in suitable damping fluid, make wedding agent contact one suitable period with solid support and can finish absorption.Vary with temperature duration of contact, but typically between about 1 hour to about 1 day.Usually, the hole of plastics titer plate (as polystyrene or polyvinyl chloride) is with approximately 10ng is to about 10 μ g scopes, and preferably approximately 100ng is enough to the fixedly wedding agent of capacity to the wedding agent contact of about 1 μ g.

The covalent attachment of wedding agent and solid support can be finished with will reacting with the bifunctional reagent of functional group on support and the wedding agent such as hydroxyl or amino reaction by at first making support usually.For example, use benzoquinones, or the support that aldehyde radical and amine on the binding partners and active hydrogen condensation on the support, wedding agent is covalently attached to have suitable polymer coating is (as seeing Pierce Immunotechnology Catalog and Handbook, 1991, A12-A13).

In certain embodiments, mensuration is that double antibodies sandwich is measured.The enforcement of this mensuration can at first make be fixed on solid support normally the antibody in the hole of titer plate contact with sample, make polypeptide in the sample in conjunction with fixed antibody.Then from fixed polypeptide-antibody complex body, remove unconjugated sample, and add the detection reagent that contains reporter group (preferably can be attached to different loci on the polypeptide two anti-).Measure the amount that keeps the bonded detection reagent with solid support with the method that is fit to specific reporter group then.

More specifically, in case after antibody was fixed on the support as mentioned above, remaining protein binding site typically was closed on the support.The known any suitable encapsulant of those of ordinary skills is as bovine serum albumin or Tween 20 ^TM(Sigma Chemical Co., St.Louis, MO).Then, fixed antibody and sample incubation make the polypeptide binding antibody.Before the incubation, can use suitable dilution dilution agent sample, as phosphate-buffered saline (PBS).Usually, suitable duration of contact (being the incubation time) is for some time of enough detecting the existence of polypeptide in the sample that obtains from the lung cancer individuality.Preferably, enough reach duration of contact combination and not in conjunction with reach between polypeptide equilibrated about at least 95% in conjunction with level.Those of ordinary skills will appreciate that to measure and carry out can being easy to determine to reach the balance required time in conjunction with level after for some time.At room temperature, about 30 minutes usually incubation time is just enough.

Then, can remove unconjugated sample with suitable damping fluid washing solid support, as contain 0.1%Tween 20 ^TMPBS.Then can be with the two anti-solid supports that add that contain reporter group.Preferred reporter group comprises above-cited those groups.

Then, detection reagent is enough to detect for some time that combines polypeptide with fixed antibody-polypeptide complex body incubation.Usually can measure and determine the suitable time in conjunction with level after for some time.Then remove unconjugated detection reagent and detect the bonded detection reagent with reporter group.The method that detects the reporter group use depends on the character of reporter group.For the radioactivity group, scintillation counting or radioautograph method are normally suitable.Spectroscopic method can be used to detect dyestuff, luminophore and fluorophor.Can use different reporter group (normally radioactivity or fluorophor or enzyme) the detection of biological element of avidin coupling.Add substrate (carrying out specific for some time usually), carry out spectroscopy analysis or other analysis of reaction product subsequently, can detect the enzyme reporter group usually.

For the existence of determining cancer such as lung cancer or do not exist, usually will be from keeping detected signal of bonded reporter group and signal to compare corresponding to predetermined cutoff value with solid support.In a preferred embodiment, the cutoff value that detects cancer is when sessile antibody and the mean value of gained signal when not having patient's sample incubation of cancer.Usually, think that the generation signal is cancer positives above the sample of three standard deviations of predetermined cutoff value.In alternative preferred embodiment, determine cutoff value with Receiver Operator Curve, according to Sackett etc., Clinical Epidemiology:A Basic Science forClinical Medicine, Little Brown and Co., 1985, the method for 106-7 page or leaf.In brief, in this embodiment, can determine cutoff value from the paired True Positive Rate (being susceptibility) of each possible cutoff value of being equivalent to the diagnostic detection result and the figure of false positive rate (100%-specificity).With cutoff value (promptly surrounding the value of maximum area) on the immediate figure in the upper left corner be cutoff value the most accurately, can think that producing the sample that signal is higher than the cutoff value of determining with this method is the positive.Alternatively, cutoff value can be moved to the left along figure, makes false positive rate reduce to minimum, or moves right, and makes false negative rate reduce to minimum.It has been generally acknowledged that the sample that the generation signal is higher than with the definite cutoff value of this method is the cancer positive.

In a relevant embodiment, measure with circulation or banded test format, wherein wedding agent is fixed on the film, as nitrocellulose.In the circulation test, when sample process film, the polypeptide in the sample combines with the fixed wedding agent.Then, when the solution stream that contains second kind of wedding agent during through film, the wedding agent of second kind of mark combines with wedding agent-complex of polypeptides.Can carry out the detection of second kind of wedding agent of bonded as mentioned above then.In banded test format, an end of wedding agent bonded film is immersed in the solution that contains sample.Sample moves by containing the regional of second kind of wedding agent and arriving fixed wedding agent district along film.Existence in the concentration indication cancer of second kind of wedding agent of fixed antibody regions.Typically, second kind of wedding agent concentration in that position produces the pattern that can naked eyes reads, as line.There is not this modal representation negative findings.Usually, the amount of selecting to be fixed on the wedding agent on the film makes when biological specimen contains the polypeptide level and is enough in the double antibodies sandwich of form is measured as discussed above the generation positive signal, produces the pattern that the naked eyes of form as discussed above can be distinguished.The wedding agent that preferably is used for this test is antibody and Fab thereof.Preferably, the weight range that is fixed on the antibody on the film is from about 25ng to about 1 μ g, more preferably from the extremely about 500ng of about 50ng.Usually available very a spot of biological specimen carries out this test.

Certainly, there are many other testing programs that are fit to oncoprotein of the present invention or wedding agent.Top explanation only is intended to demonstration.For example, will be clearly to those of ordinary skills, can be easy to improve such scheme, with in the oncopeptide detection of biological sample in conjunction with the antibody of this peptide species.The specific detection of antibodies of this oncoprotein may exist relevant with cancer.

Also can, or alternatively, based on detecting cancer with the existence of the T cell of oncoprotein generation specific reaction in the biological specimen.In some method, will be from the isolating CD4 that contains of patient ⁺And/or CD8 ⁺The biological specimen of T cell is with the polynucleotide of oncopeptide, this peptide species of encoding and/or express the APC incubation of the immunogenicity part of this peptide species at least, and detects and have or do not exist the specific, activated of T cell.Suitable biological sample includes but not limited to isolating T cell.For example, can separate the T cell from the patient with routine techniques (for example by Ficoll/Hypaque density gradient centrifugation peripheral blood lymphocyte).The T cell can be cultivated 2-9 days (common 4 days) at external 37 ℃ with polypeptide (as 5-25 μ g/ml).May preferably cultivate the T cell sample that there is not oncopeptide in another equal portions in contrast.For CD4 ⁺The T cell is preferably by estimating that T cell proliferation detects activation.For CD8 ⁺The T cell is preferably by estimating that active detection of dissolved cell activates.At least twice and/or dissolved cell activity level show that than no patient's height at least 20% there is cancer in the patient to the propagation level than no patient's height.

As noted above, also can, or alternatively, detect cancer based on the proteic mRNA level of codes for tumor in the biological specimen.For example, in based on the mensuration of polymerase chain reaction (PCR), can use at least two Oligonucleolide primers, amplification is from the part of the tumour cDNA of biological specimen, and wherein at least one Oligonucleolide primers has specificity (promptly with its hybridization) to the proteic polynucleotide of codes for tumor.Then, with technical point well known in the art from the cDNA that detects amplification, as gel electrophoresis.Similarly, can be used for cross experiment existing with the oligonucleotide probe of the proteic polynucleotide specific hybrid of codes for tumor with the proteic polynucleotide of detection of biological sample codes for tumor.

In order to allow under condition determination, to hybridize, Oligonucleolide primers and probe should comprise a polynucleotide part (at least 10 Nucleotide of length with code book invention oncoprotein, preferred at least 20 Nucleotide) have about at least 60%, preferred about at least 75% and the more preferably oligonucleotide sequence of about at least 90% identity.The polynucleotide of the polypeptide that preferred Oligonucleolide primers and/or probe and coding are described here are hybridized under medium stringent condition, are defined as above.Can be effective to the Oligonucleolide primers of diagnostic method described here and/or probe preferred length 10-40 Nucleotide at least.In a preferred embodiment, Oligonucleolide primers comprises and has here openly at least 10 continuous nucleotides of the dna molecular of sequence, more preferably at least 15 successive Nucleotide.The mensuration of PCR-based and the technology of cross experiment are well known in the art (as seeing Mullis etc., Cold Spring Harbor Symp.Quant.Biol., 51:263,1987; Erlich ed., PCR Technology, Stockton Press, NY, 1989).

Preferred mensuration is used RT-PCR, and wherein PCR and reverse transcription are united use.Typically, from biological specimen such as biopsy, extract RNA, and reverse transcription produces the cDNA molecule.Use the pcr amplification of at least one Auele Specific Primer to produce the cDNA molecule, it can separate and observation with for example gel electrophoresis.Can increase with the biological specimen of taking from the individuality of not suffering from cancer to taking from test patient.Can carry out amplified reaction to the several dilution cDNA that crosses over two orders of magnitude.Compare with same dilution no cancer sample, expressing in several dilution test patient samples increases twice or higher, is commonly referred to be the positive.

In another embodiment, composition described here can be as the mark of cancer progression.In this embodiment, can implement the mensuration of aforesaid diagnosing cancer along with the time, the change of response estimator polypeptide or polynucleotide level.For example, can measure in every 24-72 hour, continue 6 months to 1 year, implement as required thereafter.Usually, among those patients of increasing in time of the polypeptide of detection or polynucleotide level cancer in progress.By contrast, when reactive polypeptide or the polynucleotide level remains unchanged or when reducing in time, cancer is progress not.

Some in-vivo diagnostic test can directly be carried out on tumour.A this test comprises makes tumour cell contact wedding agent.Then, can directly or pass through reporter group indirect detection bonded wedding agent.This wedding agent also can be used for histology and use.Alternatively, in this application, can use polynucleotide probes.

As noted above, in order to improve susceptibility, in given sample, can measure a plurality of oncoprotein marks.Clearly, in single test, can make up wedding agent here to the different protein-specifics that provide.In addition, can use a plurality of primers or probe simultaneously.Selection oncoprotein mark can be based on routine test to determine to produce the combination of best susceptibility.And, or alternatively, the oncoprotein that provides here is provided can be measured combination with other known tumour antigen.

The present invention further provides test kit and be used for any top diagnostic method.This test kit typical case comprises the necessary composition of two or more enforcement diagnostic assays.Composition can be compound, reagent, container and/or device.For example, a container in the test kit can contain and oncoprotein specificity bonded monoclonal antibody or its fragment.Can provide this antibody or fragment and supporting body material to adhere to, as mentioned above.One or more other containers can comprise component, as measure stand-by reagent or damping fluid.This test kit is also passable, or alternatively, contains the aforesaid detection reagent that is fit to directly or indirectly detect the reporter group of antibodies that contains.

Alternatively, can design test kit with the proteic mRNA level of codes for tumor in the detection of biological sample.This test kit generally include at least one with the oligonucleotide probe or the primer of the proteic multi-nucleotide hybrid of codes for tumor, as mentioned above.This oligonucleotide for example can be used in PCR or the cross experiment.The other composition that can exist in this test kit comprises that second kind of oligonucleotide and/or diagnostic reagent or container are beneficial to detect the proteic polynucleotide of codes for tumor.

Provide following enforcement to be used for illustrating, be not used for limiting.

Embodiment 1

Usage variance shows that RT-PCR prepares lung tumor specificity cDNA sequence

This embodiment has illustrated the cDNA molecule that adopts mRNA differential display mRNA screening preparation coding lung tumor specific polypeptide.

There are the patient's of lung cancer lung tumor and healthy tissues to prepare tissue samples in the back of taking a sample from the patient from the pathology confirmation on one's body.Extract normal ribonucleic acid and tumour RNA from sample, separating mRNA is also used (dT) ₁₂AG (SEQ ID NO:47) grappling 3 ' primer changes cDNA into.Then with selecting primer (SEQ ID NO:48) to carry out differential display-PCR at random.Amplification condition is to contain 1.5mM MgCl ₂Standard buffer solution, 20 pmol primers, 500 pmol dNTP and 1 Taq of unit archaeal dna polymerase (Perkin--Elmer, Branchburg, NJ).Adopt 94 ℃ of sex change 30 seconds, 42 ℃ of annealing were extended and were carried out 40 amplification cycles in 30 seconds in 1 minute and 72 ℃.Downcut that silver dyes that repeated observation in the gel arrives to the specific band of tumour RNA finger printing pattern, subclone to the pGEM-T carrier (Promega, Madison, WI) in and check order.Isolating 3 ' sequence provides in SEQ ID NO:1-6.

With the BLASTN program sequence in these sequences and the public database is compared, show that the sequence that provides with SEQ ID NO:1-11 does not have tangible homology.Known to the contriver, none had been presented at before once that expression level is higher than normal lung tissue in the human lung cancer tissue separated DNA sequence.

Embodiment 2

Use the antigenic dna sequence dna of patients serum's identification code lung tumor

This embodiment has illustrated by the expression screening that carries out the lung tumor sample with patient's autoserum and has separated the antigenic cDNA sequence of coding lung tumor.

(Stratagene, La Jolla CA) make up the directed cDNA expression library of human lung cancer to use Lambda ZAP Express expression system.Total RNA in library takes from people's tesselated epithelium lung cancer that late period, the SCID mouse was gone down to posterity, and (Gibco BRL, Gaithersburg MD) separate polyadenylic acid+RNA with Message Maker test kit.The patient's autoserum that absorbs with intestinal bacteria screens the gained library, as (Molecular.Cloning:ALaboratory Manual as described in Sambrook etc., Cold Spring Harbor Laboratories, ColdSpring Harbor, NY, 1989), the anti-human IgG-A-M of goat (H+L) two anti-and alkaline phosphatase couplings are developed with NBT/BCIP (Gibco BRL).Purifying is expressed the positive plaque of immuno-activated-antigen.The nucleotide sequence of regaining the phagemid in the plaque and determining to clone.

Separate 15 clones, below be called LT86-1-LT86-15.SEQ ID NO:17-24 and 26-31 provide LT86-1-LT86-8 and the isolating cDNA sequence of LT86-10-LT86-15 respectively, and SEQ ID NO:32-39 and 41-46 provide corresponding predicted amino acid sequence respectively.SEQ ID NO:25 provides the cDNA sequence of determining of LT86-9, SEQ ID NO:40 and 65 provides respectively accordingly from 3 ' and 5 ' terminal predicted amino acid sequence.As mentioned above those sequences in these sequences and the gene pool are compared.Find clone LT86-3, LT86-6-LT86-9, LT86-11-LT86-13 and LT86-15 (are respectively SEQ ID NO:19,22-25,27-29 and 31) demonstrates some homologys with the expressed sequence tag of identifying in the past (ESTs), clone LT86-6, LT86-8, LT86-11, LT86-12 seems similar each other with LT86-15 or is equal to.Find that clone LT86-3 and people's transcription repressor demonstrate some homologys.Find clone LT86-6,8,9,11,12 and 15 and yeast rna Pol II transcriptional control amboceptor demonstrate some homologys.Find that clone LT86-13 and C.Elegans leucine aminopeptidase(LAP) demonstrate some homologys.Clone LT86-9 it seems that containing two inserts fragment, and its 5 ' sequence demonstrates homology with the antisense sequences of the interferon alpha-induced P27 that identified in the past, and 3 ' sequence and LT86-6 are similar.Find the β-Nei Xiananmei A site that clone LT86-14 (SEQ ID NO:30) and trithorax gene demonstrate some homologys and have " RGD " cell adhesion sequence and work in penicillin hydrolysis.Find clone LT86-1, LT86-2, LT86-4, LT86-5 and LT86-10 (being respectively SEQ ID NOS:17,18,20,21 and 26) demonstrated homology with former genes identified.SEQ ID NO:66 provides the extension cDNA sequence of the LT86-4 that determined afterwards, and SEQ ID NO:67 provides its corresponding predicted amino acid sequence.

Other five clones' separation is led in research afterwards, is called LT86-20, LT86-21, LT86-22, LT86-26 and LT86-27.SEQ ID NO:68 and 70-72 provide LT86-20 respectively, LT86-22,5 ' cDNA sequence of the mensuration of LT86-26 and LT86-27,3 ' the cDNA sequence that SEQ ID NO:69 provides LT86-21 to measure.SEQ ID NO:73-77 provide LT86-20 respectively, LT86-21, LT86-22, the corresponding predicted amino acid sequence of LT86-26 and LT86-27.Find that LT86-22 and LT86-27 are closely similar each other.With the sequence in these sequences and the gene pool relatively, demonstration and LT86-22 and LT86-27 do not have tangible homology as mentioned above.Find LT86-20, LT86-21 and LT86-26 and former genes identified demonstrate homology.

Further in the research, use mRNA to prepare the cDNA expression library, screen as mentioned above, with two small cell carcinoma of lung patients' pooled serum from the small cell carcinoma of lung clone in the lambda ZAP Express expression vector (Stratagene).Absorb pooled serum and in serum, add the protein binding of finding in human PBMC's lysate blocking antibody and the healthy tissues with the intestinal bacteria lysate.73 clones have been separated.SEQ ID NO:290-362 provides these clones' mensuration cDNA sequence.Find SEQ ID NO:289-292,294,296-297,300,302,303,305,307-315,317-320,322-325,327-332,334,335,338-341,343-352,354-358,360 and 362 sequence and former isolating gene demonstrate some homologys.Find SEQ IDNO:293,295,298,299,301,304,306,316,321,326,333,336,337,342,353,359 and 361 sequence demonstrates some homologys with the ESTs that identifies in the past.

Embodiment 3

Use the antigenic dna sequence dna of mouse resisting anteserum identification code lung tumor

This embodiment has set forth by separating the antigenic cDNA sequence of coding lung tumor with mouse anti tumour serum screening lung tumor cDNA library.

The as above directed cDNA lung tumor of embodiment 2 described preparations expression library.Serum gets the people's squamous cell that goes down to posterity self-contained late period and the SCID mouse of gland cancer tumour.Mixing these serum and injection gives normal mouse to produce anti-lung tumor serum.With this antiserum(antisera) never increase screen in the library about 200,000PFUs.Goat anti-mouse IgG-A-M (H+L) alkaline phosphatase two that uses NBT/BCIP (BRL Labs.) to develop is anti-, has identified about 40 positive plaques.Purifying phage and excision have the phagemid that inserts segmental 9 clones to be used for expressing at protokaryon or eukaryotic cell in the pBK-CMV carrier.

SEQ ID NO:49-55 provide 7 isolating clones (below be called L86S-3, L86S-12, L86S-16, L86S-25, L86S-36, L86S-40 and L86S-46) the cDNA sequence of mensuration, SEQ ID NO:56-62 provides corresponding predicted amino acid sequence respectively.SEQ ID NO:63 and 64 provides 5 ' cDNA sequence of 2 clones of residue (below be called L86S-30 and L86S-41).Determined L86S-36 and the identical gene of L86S-46 representative afterwards.As mentioned above with the sequence in these sequences and the public database relatively, show the L86S-30 with the clone, L86S-36 and L86S-46 (being respectively SEQ ID NO:63,53 and 55) do not have tangible homology.Find that L86S-16 (SEQ ID NO:51) and the EST that identifies in the past demonstrate some homologys in tire lung and germinoma.Find that residue clone and the people's gene of identifying in the past demonstrate homology at least to a certain degree.SEQ ID NO:78-80 provides the L86S-12 that determined afterwards respectively, the extension cDNA sequence of L86S-36 and L86S-46, and SEQ ID NO:81-83 provides corresponding predicted amino acid sequence.

5 ' the cDNA sequence of having determined nine other clones afterwards is called L86S-6, L86S-11, L86S-14, L86S-29, L86S-34, L86S-39, L86S-47, L86S-49 and L86S-51 (being respectively SEQ ID NO:84-92).SEQ ID NO:93-101 provides corresponding predicted amino acid sequence respectively.Find L86S-30, L86S-39 is similar each other with L86S-47.As mentioned above relatively, show with L86S-14 there is not tangible homology with the sequence in these sequences and the gene pool.Find that L86S-29 and the EST that identifies in the past demonstrate some homologys.Find L86S-6, L86S-11, L86S-34, L86S-39, L86S-47, L86S-49 and L86S-51 and former genes identified demonstrate some homologys.

In further studying, make up directed cDNA library with the Stratagene test kit of being with Lambda Zap Express carrier.Separate the total RNA in library from two primary squamous cell lung tumors, separate polyadenylic acid+RNA with oligo dT post.Use pooled serum in normal mouse, to produce antiserum(antisera) from three SCID mouse transplanting people's prognosis of squamous cell lung cancer.The mouse anti SCID tumour serum that absorbs with intestinal bacteria never increase screen in the library about 700,000PFUs.Identify positive plaque as mentioned above.Purifying phage and excision have the phagemid that inserts segmental 180 clones to be used for expressing at protokaryon or eukaryotic cell in the pBK-CMV carrier.

SEQ ID NO:126-148 provides the cDNA sequence of the mensuration of 23 separating clones.As mentioned above with the sequence in these sequences and the public database relatively, demonstration does not have tangible homology with the sequence of SEQID NO:139 and 143-148.The sequence of finding SEQ IDNO:126-138 and 140-142 demonstrates homology with people's polynucleotide sequence of identifying in the past.

Embodiment 4

Use the lung tumor library of mouse resisting anteserum screening by the preparation of SCID mouse

This embodiment has set forth by separating the antigenic cDNA sequence of coding lung tumor with the screening of mouse anti tumour serum from the lung tumor cDNA library of SCID mouse preparation.

Stratagene test kit with band Lambda Zap Express carrier prepares directed cDNA lung tumor expression library.The total RNA in library takes from the adenocarcinoma of lung that goes down to posterity in late period of growing in the SCID mouse.Separate polyadenylic acid+RNA with Message Maker test kit (Gibco BRL).Serum derives from two SCID mouse of transplanting adenocarcinoma of lung.Mixing these serum and injection gives normal mouse to produce anti-lung tumor serum.Screen in the library that the mouse anti SCID tumour serum that absorbs with intestinal bacteria never increases about 700,000PFUs.Goat anti-mouse IgG-A-M (H+L) alkaline phosphatase two that develops with NBT/BCIP (Gibco BRL) resists the positive plaque of evaluation.Purifying phage and excision have the phagemid that inserts segmental 100 clones to be used for expressing at protokaryon or eukaryotic cell in the pBK-CMV carrier.

SEQ ID NO:149-181 provides 5 ' cDNA sequence of 33 isolating clones' mensuration.SEQ ID NO:182,183,186,188-193 and 194-215 provide SEQ ID NO:149 respectively, and 150,152-154, the corresponding predicted amino acid sequence of 156-158 and 160-181.The clone's (being called SAL-25) who finds SEQ ID NO:151 contains two open reading-frame (ORF)s (ORFs).SEQ ID NO:184 and 185 provides the predicted amino acid sequence of these ORFs codings.Find that clone's (being called SAL-50) of SEQ ID NO:153 contains the open reading-frame (ORF) of the predicted amino acid sequence of two coding SEQ ID NO:187 and 216.Similarly, find that clone's (being called SAL-66) of SEQ ID NO:155 contains the open reading-frame (ORF) of the predicted amino acid sequence of two coding SEQ ID NO:189 and 190.The sequence of isolating sequence and public database is compared, show and SEQ ID NO:151 that 153 and 154 sequence does not have tangible homology.Find SEQ ID NO:149,152,156,157 and 158 sequence and former isolating expressed sequence tag (ESTs) demonstrate some homologys.Find SEQ ID NO:150,155 and the sequence of 159-181 demonstrate homology with the sequence of in the people, identifying in the past.With above-mentioned step, prepare two directed cDNA libraries (being called LT46-90 and LT86-21) and use the serum screening that obtains from the SCID mouse of transplanting people's prognosis of squamous cell lung cancer by two that in the SCID mouse, the grow lung squamous cancers that go down to posterity late period.SEQ ID NO:217-237 and 286-289 provide the mensuration cDNA sequence of separating clone.Find that SEQ ID NO:286 is the longer sequence of LT4690-71 (SEQ ID NO:237).The relatively demonstration of the sequence in these sequences and the public database and sequence SEQ ID NO:219,220,225,226,287 and 288 do not have known homology.Find SEQ ID NO:218,221,222 and 224 sequence demonstrates some homologys with the sequence of the Unknown Function of identifying in the past.Find that sequence SEQ ID NO:236 and known mouse mRNA sequence demonstrate homology.SEQ IDNO:217,223,227-237,286 and 289 sequence and known people DNA and/or RNA sequence demonstrate some homologys.

In further studying, use above-mentioned technology, the mouse anti SCID tumour serum that absorbs with intestinal bacteria screens an above-mentioned cDNA library (LT86-21).This serum must use by oneself 3 parts of serum taking from the SCID mouse of transplanting people's prognosis of squamous cell lung cancer mixing immune normal mouse.SEQ ID NO:238-285 provides the mensuration cDNA sequence of separating clone.The relatively demonstration of the sequence of these sequences and public database and SEQ ID NO:253,260,277 and 285 sequence does not have tangible homology.Find SEQ ID NO:249,250,256,266,276 and 282 sequence and former isolating expressed sequence tag (ESTs) demonstrate some homologys.Find SEQ ID NO:238-248,251,252,254,255,257-259,261-263,265,267-275,278-281,283 and 284 sequence demonstrates some homologys with DNA or the RNA sequence identified in the past.

Expression level and relatively with microarray technology the determining of expression level in healthy tissues of isolating some antigen in the lung tumor tissue.The result of these researchs shows in following table 2, together with the database analysis to these sequences.Table 2

The clone	?SEQ?ID?NO：	Explanation	??LT+F/N	??SCC+M/N	??Squa/N	??Adeno/N
							??2LT-3	?238	Unknown (KIAA0712)	??2.2	??3.8	??3.3	??-
??2LT-6	?239	Lactic acid DH B	??2.3	??3.8	??4.1	??-
							??2LT-22	?240	Fumarate hydratase	??-	??3.0	??-	??-
??2LT-26	?242	??CG1-39	??-	??-	??12.8	??-
							??2LT-31	?243	??ADH7	??-	??-	??8.4	??2.2
??2LT-36	?244	??ADH7	??-	??2.4	??2.0	??-
							??2LT-42	?245	The HMG-CoA synthase	??2.2	??2.6	??2.2	??-
??2LT-54	?247	(mouse) ninein	??-	??2.1	??-	??-
							??2LT-55	?248	Ubiqutin	??2.2	??-	??2.5	??2.0
??2LT-57	?249	New	??2.1	??2.9	??2.4	??-

??2LT-58	??250	New	??2.3	??4.0	??2.9	??-
							??2LT-59	??251	Unknown KIAA0784	??2.4	??3.0	??2.3	??2.0
??2LT-62	??252	Nuclear pore complex Rapsyn TPR	??-	??-	??-	??2.1
							??2LT-70	??256	Unknown KIAA0871	??-	??2.5	??2.2	??2.1
??2LT-73	??257	The combination of mouse polyadenylic acid	??-	??2.0	??-	??-
							??2LT-76	??259	Trans-Golgi p230	??2.1	??-	??2.6	??-
??2LT-85	??263	Ribosomal protein (LS29)	??-	??-	??-	??2.1
							??2LT-89	??265	Unknown PAC212G6	??-	??2.0	??-	??-
??2LT-98	??268	Melanoma differentiation related protein 9	??-	??-	??-	??2.2
							??2LT-100	??269	Mouse collagen alpha VI	??-	??-	??-	??2.1
??2LT-105	??271	NY-CO-7 antigen	??-	??3.2	??-	??-
							??2LT-108	??273	Unknown PG363M04	??-	??3.1	??-	??-
??2LT-124	??279	Galectin-9 (excretory)	??2.3	??2.7	??2.0	??-
							??2LT-126	??280	L1 element L1.33 p40	??2.5	??-	??3.1	??-
??2LT-128	??282	New (kappa B-ras 2)	??2.3+	??-	??20.4	??2.5
							??2LT-133	??284	Alpha II spectrin	??-	??2.3	??-	??-

The LT+F/N=lung tumor adds fetal tissue and adds transfer ratio healthy tissues Squa/N=squamous cell lung tumor than healthy tissues SC+M/N=small cell carcinoma of lung and compare healthy tissues than healthy tissues Aden/N=gland cancer

The total length of antigen 2LT-128 (SEQ ID NO:282) order-checking research is obtained the separation of the full length cDNA sequence that SEQ IDNO:392 provides.SEQ ID NO:393 provides this aminoacid sequence by this full length cDNA sequence coding.This antigen demonstrates 20 times of overexpressions in squamous cell carcinoma, 2.5 times of overexpressions in adenocarcinoma of lung.This gene has been stated is potential ras oncogene (Science such as Fenwick, 287:869-873,2000).

Obtain clone 2LT-3 (SEQ ID NO:238), 2LT-26 (SEQ-ID NO:242), 2LT-57 (SEQ ID NO:249), 2LT-58 (SEQ ID-NO:250), the extension sequence information of 2LT-98 (SEQ ID NO:268) and 2LT-124 (SEQ ID NO:279).These clones' extension cDNA sequence is enumerated in SEQ ID NOs:428-433 respectively, the peptide sequence that the SEQ ID NOs:434-439 that encodes respectively enumerates.

Embodiment 5

The tissue-specific of lung tumor polypeptide determined

Use gene-specific primer, detect the mRNA expression level of representative lung tumor polypeptide in the various normal and tumor tissues with RT-PCR.

In brief, with the Trizol reagent total RNA of extraction from various normal and tumor tissues.Carried out the synthetic of article one chain with total RNA of 2 μ g and SuperScript II reversed transcriptive enzyme (BRL Life Technologies) in 1 hour 42 ℃ of reactions.Pass through pcr amplification cDNA with gene-specific primer then.In order to ensure the sxemiquantitative character of RT-PCR, beta-actin is detected the internal reference of tissue as each.Use the cDNA of the dilution in 1: 30 of 1 μ l to make that the beta-actin template can linearity range amplification and enough responsive to reflect the difference of initial copy number.Use these conditions, each reverse transcription reaction of each tissue is determined the beta-actin level.Guarantee PCR result's feminine gender with the processing of DNA enzyme with when using article one chain cDNA that does not add the reversed transcriptive enzyme preparation and minimum is reduced in the DNA pollution.

Detect five different types of tumors tissues (from 3 patients' lung squamous cell tumor, adenocarcinoma of lung, tumor of prostate, colon tumor and lung tumor), with different healthy tissuess, comprise from the mRNA expression level in four patients' lung, prostate gland, brain, kidney, liver, ovary, skeletal muscle, skin, small intestine, cardiac muscle, retina and the testis.Find L86S-46 in lung squamous cell tumor, colon tumor and tumor of prostate with high level expression, and in other tissue that detects detection less than.Find to express among L86S-5 2 in lung tumor sample and 4 normal lung samples, but in other the normal or tumor tissues that detects, do not express.Find expression during the institute of L86S-16 removing normal hepatocytes and normal stomach in a organized way.Use PCR in real time, find L86S-46 overexpression in lung flaser texture and normal tonsilla, in all other tissues that detect, express low or detection less than.

Embodiment 6

Separate the antigenic dna sequence dna of coding lung tumor

The antigenic dna sequence dna that the potential participation squamous cell lung tumor of encoding forms separates as follows.

(Stratagene, La Jolla CA) make up the directed cDNA expression library of lung tumor to use Lambda ZAP Express expression system.The total RNA in library takes from the mixture of two people's tesselated epithelium lung cancer, and (Gibco BRL, Gaithersburg MD) separate polyadenylic acid+RNA with the oligo-dT Mierocrystalline cellulose.Regain phagemid at random and measure the cDNA sequence of separating clone.

SEQ ID NO:102 provides the mensuration cDNA sequence of clone SLT-Tl, and SEQ IDNO:103-110 provides clone SLT-T2 respectively, SLT-T3, SLT-T5, SLT-T7, SLT-T9, S-LT-T10,5 ' cDNA sequence of the mensuration of SLT-T11 and SLT-T12.SEQID NO:111-115 provides SLT-T1 respectively, SLT-T2, SLT-T3, the aminoacid sequence of the corresponding prediction of SLT-T10 and SLT-T12.As mentioned above with SLT-T2, SLT-T3, SLT-T5, SLT-T7, the sequence of SLT-T9 and SLT-T11 and those sequences in the public database relatively, showing does not have tangible homology.The sequence of finding SLT-T10 and SLT-T12 demonstrates some homologys with the sequence of identifying in the past in the people.

Determine that the sequence of SLT-T1 and the pac clone of protein function the unknown demonstrate some homologys.The cDNA sequence (SEQ ID NO:102) of finding SLT-T1 contains and increases change (MUTT) structural domain.Known this structural domain can cause during the A transversion is for the guanine for the damage of G and works (as seeing el-Deiry, W.S., 1997 Curr.Opin.Oncol.9:79-87 removing from DNA; Okamoto, 1996 Int.J.Cancer 65:437-41 such as K.; Wu, 1995 Biochem.Biophys.Res.Commun.214:1239-45 such as C.; Porter, 1996 Chem.Res.Toxicol.9:1375-81 such as D.W.).Therefore SLT-Tl can be used for the treatment of by cause or the relevant with it lung cancer of destruction in the DNA reparation by gene therapy.

In further studying, the antigenic dna sequence dna that the potential participation gland cancer lung tumor of encoding forms separates as follows.(Stratagene, La Jolla CA) make up the directed cDNA expression library of human lung cancer to use Lambda ZAP Express expression system.The total RNA in library takes from the human adenocarcinoma that late period, the SCID mouse was gone down to posterity, and (Gibco BRL, Gaithersburg MD) separate polyadenylic acid+RNA with Message Maker test kit.Regain phagemid at random and measure the cDNA sequence of separating clone.

SEQ ID NO:116-120 provides five separating clones mensuration 5 ' cDNA sequence of (being called SALT-T3, SALT-T4, SALT-T7, SALT-T8 and SALT-T9), and SEQID NO:121-125 provides corresponding predicted amino acid sequence.Find that SALT-T3 and the human transducin sample enhanser albumen TLE2 that identifies in the past demonstrate 98% identity.It seems that SALT-T4 be people's homologue of mouse H β 58 genes.Find that SALT-T7 and people's 3-mercaptopyruvate sulfurtransferase have 97% identity, find that SALT-T8 and human interferon inducible protein 1-8U demonstrate homology.SALT-T9 and people's Saliva Orthana MUC 5B demonstrate about 90% identity.

The antigenic cDNA sequence that the potential participation small cell lung cancer of encoding takes place is separated as follows.Use Lambda ZAP Express expression system (Stratagene, La Jolla, CA), being used for (all can be from American Type Culture Collection from small cell lung cancer clone NCIH69, NCIH128 and DMS79, Manassas, VA obtains) mRNA construction cDNA expression library.Regain the cDNA sequence of phagemid and definite 27 separating clones at random.The relatively demonstration of the cDNA sequence of measuring does not have tangible homology with the sequence of SEQ ID NO:372 and 373.SEQ ID NO:364,369,377,379 and 386 sequence and former isolating ESTs demonstrate some homologys.20 clones' of residue sequence demonstrated some homologys with former genes identified.SEQ ID NO:363,365-368,370,371,374-376,378,380-385 and 387-389 provide these clones' cDNA sequence, SEQ ID NO:363 wherein, 366-368,370,375,376,378,380-382,384 and 385 is full length sequences.

Relatively the cDNA sequence of SEQ ID NO:372 shows that this clone (being called 128T1) is a newcomer of the seven-transmembrane protein family of inferring.Particularly, the algorithm PSORT that uses a computer predicts that this albumen is IIIA type plasma membrane seven-transmembrane albumen.Identified genomic clone in the Genbank database, it contains 58 amino acid of N-terminal of the prediction that SEQ ID NO:372 amino acid sequence coded lacked.SEQ ID NO:390 provides the 128T1 clone's who measures full length cDNA sequence, and SEQ ID NO:391 provide amino acid sequence corresponding.

With microarray technology measure some separate antigen in the lung tumor tissue with the expression level of in healthy tissues, comparing.These results of study show in following table 3, together with the database analysis to these sequences.Table 3

The clone	SEQ?ID?NO：	Explanation	LT+F/N	SCC+M/N	Squa/N	Adeno/N
							DMS79-T1	363	The STAT-ind inhibition of cytokine	-	2.0	-	-
DMS79-T6	367	Neuronal cell is dead relevant	-	2.2	-	-
							DMS79-T9	369	New	-	2.2	-	-
DMS79-T10	370	The ubiqutin carrier proteins	-	3.9	2.2	-
							DMS79-T11	371	HPV16E1 pro is conjugated protein	-	2.1	-	-
128-T9	378	EF-1 α	-	2.7	-	-
							128-T11	380	Malate dehydrogenase (malic acid dehydrogenase)	-	2.3	2.0	-
128-T12	381	Remove purine/remove pyrimidine nucleic acid restriction endonuclease	-	5.4	-	-
							NCIH69-T3	382	Sm sample PROTEIN C aSm	-	-	2.4	-
NCIH69-T6	384	Transcription factor BTF3a	-	?2.5	-	-

The LT+F/N=lung tumor adds fetal tissue and adds transfer ratio healthy tissues Squa/N=squamous cell lung tumor than healthy tissues SC+M/N=small cell carcinoma of lung and compare healthy tissues than healthy tissues Aden/N=gland cancer

Embodiment 7

Synthesizing of polypeptide

Can on Perkin Elmer/AppliedBiosystems DiVision 430A peptide synthesizer, synthesize polypeptide with FMOC chemical process and HPTU (O-benzotriazole-N, N, N ', N '-tetramethyluronium phosphofluoric acid) activation.The Gly-Cys-Gly sequence can link to each other with the N-terminal of peptide coupling to be provided, to be bonded to the method for fixed surface or mark peptide.Can use following cleavage mixture: trifluoroacetic acid: ethylene dithiol phenol: thioanisole: water: phenol (40: 1: 2: 2: 3) downcuts peptide from solid support.Cut after 2 hours, can be in cold methyl tertiary butyl ether precipitation of peptides.The peptide precipitation can be dissolved in the water that contains 0.1% trifluoroacetic acid (TFA) and lyophilize before with C18 reversed-phase HPLC purifying then.Can use the gradient elution peptide of 0%-60% acetonitrile (containing 0.1%TFA) in water (containing 0.1%TFA).After the pure fraction of lyophilize, use the mass spectrometry and the amino acid analysis of electrospray or other type to characterize peptide.

Embodiment 8

By T cell expressing clone and separate and the antigenic dna sequence dna of sign coding lung tumor

Also can identify lung tumor antigen with T cell expressing clone.The tumour since the excision of people's corrective surgery is come in a source of tumour-specific T cell.

With nonsmall-cell lung cancer chopping and enzymatic digestion several hrs lymphocyte (tumor-infiltrated T cell, or TILs) with release tumor cell and infiltration.Also (100%/75%/HBSS) discontinuous gradient is to separate non-activity cell and tumour cell and lymphocyte by Ficoll for washed cell in the HBSS damping fluid.Gather in the crops two bands from interface; Band mainly contains tumour cell above the 75%/HBSS interface, and band contains most of lymphocytes below 100%/75%/HBSS interface.Cultivate and expand TILs, in 24 orifice plates that contain the substratum that adds 10ng/ml IL-7 and 100U/ml IL-2, or alternatively, wrapping in advance with CD 3-resisting monoclonal antibody OKT3 in 24 orifice plates of quilt.Is CD8 with facs analysis gained TIL culture with what confirm to account for high per-cent ⁺T cell (by more than 90% of colony), CD4 ⁺Cell only accounts for little per-cent.

In addition, use standard technique to cultivate and expand non-small cell lung cancer cell, confirmed through immunohistochemical analysis that it was a lung cancer cell line afterwards to set up tumor cell line (being called LT391-06).Come expressing human CD80 with retroviral vector this tumor cell line of transduceing, and characterize by facs analysis and to confirm its CD80, the high expression level of I class MHC and II class MHC molecule.

Release of cytokines measure (IFN-γ and TNF-α) and ⁵¹Cr discharges to measure proves that TIL is the ability of specific recognition self lung tumor.In brief, from the til cell of the 21st day culture and self or allochthonous tumour cell, EBV-immortalization LCL, or control cells is Daudi and K562 co-cultivation, with the existence of ELISA monitoring culture supernatant cytokine.TIL specific recognition self tumour but the allochthonous tumour of nonrecognition.In addition, nonrecognition EBV-immortalization LCL or control cells system, show TIL system be tumour-specific and potential identification by the tumour antigen of self MHC molecular presentation.

LCLs that use solubility anti-cd 3 antibodies and the EBV through shining transform in culture and PBL feeder cell extend to suitable quantity with the system of the tumour-specific TIL through characterizing and clone to carry out the T cell expressing in the presence of 20U/ml IL-2.Produce the clone of the expansion TIL system of hanging oneself with the standard limiting dilution technique.Specifically, til cell is seeded in the 96 hole U base plates with 0.5 cells/well and with self tumour cell of CD-80 transduction, LCL and PBL feeder cell that EBV transforms stimulate in the presence of 50U/ml IL-2.With ⁵¹Cr microcytotoxicity test and IFN-γ biological assay confirm the specificity of these clones to self tumour.

These ctl clones of antibody blocking evidence are that HLA-B/C is restrictive.Detect representational ctl clone on allogeneic lung cancer plate, it discerns self tumour and squamous cell lung carcinoma (936T).Because unique I class MHC molecule that these tumours have jointly is HLA-Cw1203, this shows that this is the employed limiting factor of CTL.CTL identification has confirmed this discovery with the multiple allogeneic lung cancer of the retroviral vector transduction of coding HLA-Cw1203.

Use Message Maker (Life Technologies; Rockville is MD) from being called the preparation polyadenylic acid mRNA of lung tumor cell system of LT391-06.Comprise the cDNA synthetic afterwards step carry out according to Life Technologies clone guide (the SuperScript Plasmid System of the synthetic and plasmid clone of cDNA).The following scheme of carrying out is improved.In adding the connector step, displacement EcoRI-XmnI linker (New England Biolabs; Beverly, MA).The cDNAs of size fractionation is connected to expression vector system HisMax A, B, C (Invitrogen; Carlsbad, CA) in to optimize the protein expression in whole three coding frameworks.Then, with about 100CFU/ hole the library plasmid is distributed to the sealing of 96 holes and the liquid amplification of spending the night.From these cultures, automatic robot (Qiagen; Valencia, CA) preparation glycerine stoste and mixing plasmid.The concentration of determining plasmid DNA in each hole of library plate is about 150ng/ul.24 original transformant of random sequencing and with institute's calling sequence at utilizing database to carry out BLAST retrieval, tentatively characterize the cDNA expression library.SEQ ID NO:443-480 provides the cDNA sequence of measuring, and the BLAST result for retrieval provides in table 4.Table 4

The clone	SEQ?ID?NO：	The GenBank accession number	Explanation
				55163	458，459		Be new in Genbank
55158	452		Be new in Genbank
				Homology with the known array of Unknown Function
55153	443，444	7018516	Homo sapiens mRNA; CDNA DKFZp434M035
				55154	445，446	6437562	Homo sapiens chromosome 22q11 pac clone p393
55157	450，451	2887408	Homo sapiens KIAA0417 mRNA
				55165	462，463	3970871	Homo sapiens HRIHFB2122 mRNA
Homology with the known known array of function
				55155	?447	7677405	Homo sapiens F-box albumen FBS (FBS)
55156	?448，449	3929584	Homo sapiens EEN pseudogene
				55161	?454，455	4503350	Homo sapiens cdna (the methyltransgerase 1 (DNMT1) of cytosine(Cyt)-5-)

				55162	456，457	31220	The ERK1 mRNA of albumen serine/threonine kinase
55164	460，461	6677666	Homo sapiens's rna binding protein (autoantigen) (RALY)
				55166	464，465	3249540	Homo sapiens's Yeast Nucleic Acid acid P protein protomer p40 (RPP40)
55167	466，467	7657497	Homo sapiens's tumor of kidney antigen (RAGE)
				55168	468，469	2873376	Homo sapiens exportin t mRNA
55169	470，471	3135472	Conjugated protein sample 2 mRNA of homo sapiens Cre
				55171	474	4759151	Homo sapiens's spermine synthase (SMS)
55173	476	6688148	The proteic part mRNA of homo sapiens NICE-3
				55174	477，478	531394	People's transcriptional coactivator PC4
55175	479	6563201	Homo sapiens's translation initiation factor eIF-2b delta subunit
				55176	480	29860	The hCENP-B gene, kinetochore autoantigen B (CENP-B)
Homology with ribosomal protein
				55159	453	337494	The big Subunit mRNA of ribosome protein L 7/L a (surf 3)
55170	472，473	4506648	The mRNA of homo sapiens's ribosomal protein L 3
				55172	475	388031	Homo sapiens's ribosomal protein L 11

For the T cell screening, lipid Fugene is mixed also duplicate transfection to the COS-7 cell with about 80ng library plasmid DNA and 80ng HLA-Cw1203 plasmid DNA according to the operation instruction of manufacturers.37 ℃ cultivate 48 hours after, remove transfection mixture and in each hole, be added in 10,000 LT391-06 CTL in the fresh culture that contains human serum.

6 hours (TNF-α, WEHI biological assay) back or 24 hours (IFN-γ, ELISA) after, estimate antigenic ability in the T cell recognition library by release of cytokines.In the COS-7 cell, screen about 2.0 * 10 with this system ⁵Individual clone (100 plasmid storehouses).Three plasmid storehouses (being called 14F10,19A4 and 20E10) of LT391-06 CTL identification have been identified.These plasmid storehouse transfections make in the COS-7 cell IFN-γ that produces from LT391-06 CTL and TNF-a level apparently higher than background.14F10,19A4 and 20E10 storehouse " decomposition " are a hundreds of independent plasmid DNA and repeated test.SEQ ID NO:481-511 provides from the sequence of isolating 24 new clones in 14F10 storehouse.

A plasmid (3D9) in 14F10 storehouse, and plasmid in 20E10 storehouse and 5 plasmids in 19A4 storehouse (2A6,2E11,2F12,3F4 3H8) can reconstitute the T cell recognition.Thereby these plasmid order-checkings have been identified that 7.8kB cDNA inserts fragment (being called clone 14F10), and 2.2kB cDNA inserts fragment and (is called clone 19A4; SEQ ID NO; 440) and be called the clone of 20E10.SEQ ID NO:441 provides the full length cDNA sequence of 14F10.Clone 14F10 is not contained in 5 ' terminal preceding two " G " Nucleotide of finding of 19A4, and 24 bp of the 3 ' near-end of 19A4 are different with the respective regions (Nucleotide 2145-2165) of 14F10.3 ' the additional sequences of having separated in addition, 14F10 clone's 3837bp.SEQID NO:442 provides 5 ' the terminal cDNA sequence (337bp) of clone 20E10.At 5 ' least significant end, 20E10 contains extra 3 Nucleotide (comparing with 19A4).5 ' the terminal additional sequences of clone 20E10 contains " ATG ", therefore it seems the translation initiation site that contains new open reading-frame (ORF).The BLAST retrieval analysis of GenBank database is identified that these sequences and brachymemma people Gelucystine/L-glutamic acid reporter gene have significant homology.Yet, not resembling disclosed sequence, clone 14F10 and 19A4 contain the uniqueness 5 ' end of being made up of 181 Nucleotide.This new sequence replaces disclosed 5 ' district, has caused removing two other amino acid of initial methionine of reporting (initiator codon) and the translocator of reporting.Therefore, the translation product of clone 14F10 and 19A4 is different with Gelucystine/glutamate transporter.In addition, other lung tumor of T cell recognition proves that other tumour also expresses this antigen.

Reconstituting the clone 19A4 of the anti-LT391-06 cell of T cell recognition and the epi-position and the aminoacid sequence of the interior coding of 14F10 maps as follows.Titer cDNA with 80ng/ hole HLA-Cw1203 and coding clone 19A4, be positioned at the potential open reading-frame (ORF) of the uniqueness 5 ' end of 19A4, or the open reading-frame (ORF) of Gelucystine/L-glutamic acid (Cys-Glu) transporter gene, be cloned into transfection Cos-7 cell in the carrier for expression of eukaryon, and detect the stimulation of anti-LT391-06 T cell in the TNF mensuration.As positive control, with HLA-Cw1203 and above-mentioned positive plasmid clone 19A4 cotransfection Cos-7 cell.Use is template to the known ORF specific 5 ' and the 3 ' primer of translocator with 19A4, adopts PCR separation of C ys-Glu translocator expression construct.In addition, each 5 ' primer contains Kozak translation initiation site and initial methionine to drive the translation of polypeptide.The transfectant of Cys-Glu translocator construct is expressed in the CTL nonrecognition of anti-LT391-06, but the transfectant of the 5 ' ORF of certain recognition expression 19A4 and 19A4.

In experiment afterwards, with 80ng/ hole HLA-Cw1203 respectively with the titer DNA cotransfection Cos-7 cell of swivel base mutant F10 and C12, and detect TNF measure in the stimulation of anti-LT391-06T cell.As positive control, with 5 ' the ORF clone cotransfection Cos-7 cell of HLA-Cw1203 and 19A4.Obtain swivel base mutant F10 and C12 by 14F10 clone's transposon-mediated sudden change and by sequential analysis screening insertion site.The transposon of mutant F10 is inserted into the about 304bp of 5 ' the EcoRI cloning site place from 14F10 cDNA.This sudden change does not interrupt the translation of t cell epitope.By contrast, find that the transposon of mutant C12 inserts from the about 116bp of 5 ' the EcoRI cloning site place of 14F10 cDNA, interrupted the translation of t cell epitope.Therefore with the epitope mapping among the 14F10 between these two transposon insertion sites.SEQ ID NO:586 provides the aminoacid sequence in zone between C12 and the F10 transposon insertion site.

A series of 11 eclipsed 16-aggressiveness and 15-mer peptides and detect the stimulation of anti-LT391-06 cell in the zone shown in the preparation SEQ ID NO:586, release of cytokines is determined in being measured by TNF and IFN-γ.The peptide stimulating cytokine that has only SEQ ID NO:587 (the residue 5-20 that is equivalent to SEQ ID NO:586) to provide discharges.These studies have shown that and contain the antigenic HLA-Cw1203 restricted epitope of LT391-06 among the SEQID NO:587.

Embodiment 9

Subduing (PCR subtraction) by PCR separates and the antigenic dna sequence dna of sign coding lung tumor

This embodiment has described the separation and the sign of subduing the cDNA clone that expression library obtains from the PCT of above-mentioned human lung cancer's clone LT391-06 preparation.

As mentioned above from clone LT391-06 preparation test polyadenylic acid mRNA.From from non-pneumonocyte and do not known others acute T chronic myeloid leukemia/T lymphocyte clone (Jurkat) and separate and drive polyadenylic acid mRNA by the LT391-06 reaction-ive T cell.(Palo Alto CA) subdues, and makes the following changes: 1) use enzyme mixture (MscI, PvuII, StuI and DraI) to finish cDNA restrictive diges-tion reaction for the second time according to the method for Clontech.This is additional and the single Restriction Enzyme digestion of carrying out with RsaI that is independent of that Clonetch recommends.Each restrictive diges-tion group is handled to guarantee that finally mixed library contains the eclipsed fragment as independent library.Therefore, the epi-position of T cell recognition should be present on the fragment in the library and not destroy because of the existence of single restriction site wherein.2) in hybridization step, increase the ratio that drives with test cDNA and subdue severity with increase.In order to analyze the efficient of subduing, pcr amplification Actin muscle from the dilution of the PCR sample subduing and do not subdue.Amplification step is used the primer that is obtained by those normal primer modifications of using for the second time.Designing three nested PCR primers makes it contain cut EcoRI site (not using) in one of three frameworks in clone's process.Therefore, the amplification of carrying out with these primers second time has produced the product that can be directly connected among the eukaryon expression plasmid pcDNA4His/Max-Topo (Invitrogen).This subdues PCR and fragment somewhere in the library of increasing meets frame.Because the mechanism of subduing is correct direction with the fragment that only has 50%.Subdue expression library from the PCR of final blending, be called that 96 cloning and sequencings of random choose characterize library complicacy and Feng Yuxing among the LT391-6PCR.Analyze these sequences (SEQ ID NO:512-581) (table 5) by utilizing sequence in the database to make comparisons with the public.Table 5

The clone	SEQ?ID?NO：	The GenBank accession number	Explanation
				57235	?532		Be new in Genbank
57255	?547		Be new in Genbank
				57264	?554		Be new in Genbank
Homology with the known array of Unknown Function
				57215	?518	?5689540	The proteic mRNA of homo sapiens KIAA1102
57223	?522	?2341006	3 ' the end of people Xq 13 PAC92E23
				57227	?524	?7022540	Homo sapiens cDNA FLJl0480 fis, clone NT2RP2000126
?57238	?535	?6807795	Homo sapiens mRNA;

			cDNA?DKFZp761?G02121
				57239	536	5757546	Homo sapiens clone DJ0823F17
57243	539	7023805	Homo sapiens cDNA FLJ11259 fis, clone PLACE1009045
				57245	540	4884472	Homo sapiens mRNA; CDNA DKFZp58602223
57267	557	6808218	Homo sapiens mRNA; CDNA DKFZp43401519
				57268	558	10040400	The sequence 12 of patent WO9954460
57270	560	7959775	Homo sapiens PR01489 mRNA
				57271	561	4500158	Homo sapiens mRNA; CDNA DKFZp586B0918
57281	567	6560920	Homo sapiens clone RP11-50107
				57283	569	285962	The mRNA of people KIAA0108 gene
57285	570	7019813	Homo sapiens cDNA FLJ20002 fis, clone ADKA01577
				Homology with the known known array of function
57207	512	517176	Homo sapiens YAP65 mRNA
				57210	514	6841233	Homo sapiens HSPC292 mRNA
57211	515	2606093	Homo sapiens Cyr61 albumen (CYR61) mRNA
				57212	516	339648	Trx (TXN) mRNA
57219	519	4504616	Homo sapiens's insulin-like growth factor binding protein 3 (IGFBP3)
				57221	520	7274241	The retinal pigment epithelium albumen (NORPEG) that the homo sapiens is new
57222	521	189564	The people, Type 1 plasminogen activator inhibitor-1 gene
				57228	525	4757755	Homo sapiens's annexin A2 (ANXA2)
57230	527	180800	People α-1 IV Collagen Type VI gene, exon 52
				57232	529	6729061	The homo sapiens is from the clone RPC11-98D12 of 7q31
57233	530	338391	Spermidine/spermine N1-acetyltransferase

??57234	??531	??7305302	Homo sapiens NCK Rapsyn 1 (NCKAP1)
				??57236	??533	??4929722	Homo sapiens CGI-127 albumen
??57242	??538	??4503558	Homo sapiens's epithelial membrane albumen 1 (EMP1)
				??57248	??541	??183585	People's pregnancy specific β glycoprotein c
??57250	??543	??4759283	Homo sapiens's ubiqutin C-terminal esterase Ll (UCHL1)
				??57251	??544	??1236321	Human laminin γ 2 chain genes (LAMC2)
??57253	??545	??213831	Homo sapiens's lysyl hydroxylase isoform 2 (PLOD2)
				??57254	??546	??536897	People's FSTL3 precursor mRNA
??57257	??548	??339656	The human endothelial cell thrombomodulin
				??57258	??549	??190467	Human prion protein (PrP) mRNA
??57261	??551	??338031	People's serglycan gene
				??57262	??552	??178430	People alphoid DNA (alphoid tumor-necrosis factor glycoproteins)
??57265	??555	??4502562	Homo sapiens's calpain, big polypeptide L2 (CAPN2)
				??57266	??556	??398163	The mRNA of homo sapiens's IGFBP-3
??57269	??559	??7262375	H. Procaine esterase 2 (intestines, liver) (CES2)
				??57272	??562	??467560	The mRNA of homo sapiens's cysteine dioxygenase 1 type
??57274	??563	??482664	Homo sapiens's annexin A 3 (ANXA3)
				??57275	??564	??2281904	Homo sapiens Bruton ' s Tyrosylprotein kinase (BTK), α-D-Ban Rutangganmei A (GLA)
??57277	??565	??4557498	Conjugated protein 2 (CTBP2) of homo sapiens's C-terminal
				??57282	??568	??189245	The people, NAD (P) H: vitamin k4 oxydo-reductase mRNA
??57287	??571	??28525	The mRNA of people's alzheimer's disease amyloid A 4 precursors
				??57288	??572	??4757755	Homo sapiens's annexin A2 (ANXA2)
??57289	??573	??5729841	Homo sapiens's GLO-I (GL01) mRNA
				??57290	??574	??6103642	Homo sapiens F-box albumen FBX3 mRNA
??57295	??576	??182513	People's ferritin L chain mRNA

??57299	??579	??37137	The mRNA of human blood platelets reactive protein
				??57301	??580	??179682	People (clone A12) the conjugated protein β chain of C4b
??57302	??581	??6042205	Homo sapiens's film Zinc metalloproteinase (neutral endopeptidase, enkephalinase, CALLA, CD10) (MME)
				??57213	??517	??2665791	Homo sapiens's caveolin-2 mRNA
??57259	??550	??2665791	Homo sapiens's caveolin-2 mRNA
				??57225	??523	??179765	People's calcyclin gene
??57229	??526	??179765	People's calcyclin gene
				??57237	??534	??186962	Human laminin B2 chain gene
??57249	??542	??186962	Human laminin B2 chain gene
				??57231	??528	??4972626	Homo sapiens's caveolin 1 (CAV1) gene
??57296	??577	??4972626	Homo sapiens's caveolin 1 (CAV1) gene
				??57297	??578	??4972626	Homo sapiens's caveolin 1 (CAV1) gene
??57240	??537	??266237	Insulin-like growth factor binding protein 3
				??57292	??575	??184522	White-3 genes of human insulin-like growth factor binding protein
??57263	??553	??4504618	Homo sapiens's insulin-like growth factor binding protein 7 (IGFBP7)
				??57280	??566	??4504618	Homo sapiens's insulin-like growth factor binding protein 7 (IGFBP7)
Homology with ribosomal protein
				??57209	??513	??337504	The mRNA of human rebosomal protein S24

Embodiment 10

Separate and characterize from TXi Baoshouti to the T cell clone of lung tumor antigen-specific

This embodiment has described to lung tumor cell being TXi Baoshouti (TCR) α of CD8 T cell clone of the antigen-specific expressed of LT391-06 and clone and the order-checking of β.The life-span of T cell is limited.The clone of TCR chain and transfer subsequently will make the T cell-specific can infinite multiplication basically.The clone of tumour antigen TCR chain allows transspecific is given from the isolating T cell of the patient with TCR MHC restriction allele.This then T cell transfer techniques that can expand and be used to into to continue carries the patient that expresses this antigenic tumour (as seeing J.Immunol.163:507 (1999) such as Clay) so that specific for tumour antigen is imported.

Generation is the specific cytotoxic T lymphocyte of LT391-06 (CTL) clone to lung tumor cell.Use Trizol reagent from 15 this clones' 2 * 10 ⁶Separate total mRNA in the individual cell, and synthesize cDNA with Ready-to-Go test kit (Pharmacia).In order to determine Va and the Vb sequence among these clones, synthetic a series of Va and Vb hypospecificity primer also are used for from the RT-PCR reaction of the cDNA of each clone's generation.Each clonal expression common of RT-PCR reaction proof is corresponding to the Vb sequence of Vb13 subtribe.Use determines that from the cDNA that one of clone (being called 1105) produces expressed Va sequence is Va22.For from cloning 1105 full TCR α of clone and β chains, design the TCR Nucleotide that primer is crossed over initial son of coding and terminator.With from ctl clone synthetic cDNA and primer, and PWO (BMB) sets up 35 circulation RT-PCR reactions of standard as heat-resisting polymerase.The specific band (about 850bp of α chain and the about 950bp of β chain) of gained is connected to PCR flush end carrier (Invitrogen) and is converted into intestinal bacteria.Identify the intestinal bacteria that transform with the plasmid that contains total length α and β chain, the corresponding plasmid of mass preparation.The plasmid that contains total length TCR α and β chain is checked order.SEQ ID NO:583 and 582 provides the cDNA sequence of the mensuration of α and β chain respectively, and SEQ ID NO:584 and 585 provides amino acid sequence corresponding respectively.

Will be appreciated that from aforementioned,, can carry out various modification and without departing from the spirit and scope of the present invention although illustrative purposes has for example been described specific embodiments of the present invention here.Therefore, except claims, the present invention is unrestricted.

Sequence table

<110>Corixa?Corporation

Reed，Steven?G.

Henderson，Robert?A.

Lodes，Michael?J.

Fling，Steven?P.

Mohamath，Raodoh

Algate，Paul?A.

Secrist，Heather

Indirias，Carol?Yoseph

Benson，Darin?R.

Elliot，Mark

Mannion，Jane

Kalos，Michael?D.

＜120〉composition and the method for treatment and diagnosing

<130>210121.47501PC

<140>PCT

<141>2001-03-38

<160>587

<170>FastSEQ?for?Windows?Version?3.0

<210>1

<211>339

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>1gtactcagac?aggatagtca?tcatgtagca?caaagcamat?cctgtttcta?tacttgtagt?????60ttgctctcac?tcagtggcat?ratcattact?atacagtgta?gaatgttrtt?atgtagcata????120gatgtggggt?ctctagccca?cagctctsta?cctttgtcta?gcactcctgt?cctcatacct????180ragtggcctg?tccatcagca?tgtttctcat?ctactttgct?tgtccagtcc?actgtggtcc????240tcccttgccc?tctcccttat?gtggcagagt?ggaaccagct?gtcctgagac?ttgagttcaa????300catctggttc?gcccatytgc?atgtttgtgg?tctgagtac???????????????????????????339

<210>2

<211>698

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(698)

＜223〉n=A, T, C or G

<400>2gtactcagac?cacgactgca?ttttctccac?tgctgacggg?tctaatacca?gctgcttccc?????60tttcttggag?gcagagctng?tgaccttgag?aaagtgacct?gtgaccatca?tgtgggtagt????120gagctgctgc?aaggtgtcat?gggagctccc?acactccatg?cactttwaga?tctgggactt????180gcaggcctca?ractgccagg?tgtagctcgc?tccattttgg?tagccatagc?gsttgttgga????240ggacaactgc?aagttggcgt?tcttctgaga?agaaaaagaa?tctgcaaaag?atcctgtggt????300tgaatcgggg?gaacacggcc?gattgacatc?aaaaacgcgt?ttcttagccc?gggtgaccat????360tttcgaggaa?atggttgggg?actggctcct?tcaaaggcac?tttttggtta?tgttttgttt????420yaatcatgtk?gacgctccaa?tcttggragg?gaatcgaang?rantcnccnc?caaaacatrc????480stttcagraa?ccttttgarc?atcctctttt?ttccgtrtcc?cggmaargcc?cytttccckg????540ggctttgaaa?wyagcctsgt?tgggttctta?aattaccart?ccacnwgttg?gaattccccg????600ggccccctgc?ccggktccaa?ccaattttgg?graaaacccc?cncansccgt?tkggantgcn????660acaacntggn?ntttttcntt?tcgtgntccc?ctngaacc????????????????????????????698

<210>3

<211>697

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(697)

＜223〉n=A, T, C or G

<400>3gtactcagac?ccccaacctc?gaacagccag?aagacaggtt?gtctcctggg?ccttggacac?????60agccngccag?gccattgaag?ganaagcaaa?gacgaagcga?accatctctc?tccattgtgg????120gggccaagta?gctgcantan?ccttcagtcc?cagttgcatt?gggttaaaga?gctcatacat????180actatgtgtn?aggggtacag?aagcttttcc?tcatagggca?tgagctctcc?nagagttgac????240cttttgcctn?aacttggggt?ttctgtggtt?cataaagttn?ggatatgtat?tttttttcaa????300atggaanaaa?atccgtattt?ggcaaaaaga?ctccaggggg?atgatactgt?ccttgccact????360tacagtccaa?angatnttcc?ccaaagaata?gacatttttt?cctctcatca?cttctggatg????420caaaatcttt?tatttttttc?ctttctcgca?ccnccccaga?ccccttnnag?gttnaaccgc????480ttcccatctc?ccccattcca?cacgatnttg?aattngcann?ncgttgntgg?tcgggtcccn????540nccgaaaggg?tntttttatt?cggggtnctg?anttnnnaac?cnctnagttg?aatccgcggg????600gcggccnngn?gggttnnacc?atgntgggga?naactncccn?ccgcgnttgg?aatgccanag????660ccttgaaant?tttcttttgg?tcgccccccn?gagattc?????????????????????????????697

<210>4

<211>712

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(712)

＜223〉n=A, T, C or G

<400>4gtactcagac?aaccaatagg?tgtgttyctc?anatctgaaa?cacaaaaaga?ttctagctna?????60taatgttsaa?tggttgaggg?tttaagtgat?cttggtatgt?tngatttagc?agcgatnggc????120cgggtgcggt?ggctcacgca?tgtatcccag?cactttggga?ggccgaggca?ggaggatcac????180ctgaggtcag?gagtttgaga?ccagcctggc?cgacatggtn?aaaccccgtc?tctactanga????240atacanaaat?tagcccgggc?atagtggcgc?gtgcctrtga?cctcsgctac?tttggggatt????300ctcctgagga?agaattgctt?gaactcaggg?aagtggargt?ttgcagtgag?cttaaatcaa????360gccactggca?ctcccagcct?gggktaacag?agccamgact?ctkgccgaaa?aaaaaraama????420cgacggagaa?nmagntctgt?tattccatgg?gaaattkgaa?tttccttcyt?tkaaatatct????480taaaatnggt?cctcctwaaa?aaagttcggc?tggggcccgk?tggctcacat?tttkttaycc????540cycccccttt?tggggarggc?caarggccgg?kttgawtnnc?ccttgagggg?ccanaactcc????600agnaaccrgn?cccgggccar?smgwkgkstr?armccctttc?cyyccmaraa?aawwcsmaaa????660wwttycccsc?cygsykggct?ggkasckgtt?myyyyygmtm?csyagcttgc?tt????????????712

<210>5

<211>679

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(679)

＜223〉n=A, T, C or G

<400>5gtactcagac?cacctcacat?gcagggtnag?aaacatggag?tgtgcggcag?catcctcctc?????60acatcccttt?gtgagcacgg?ctgctccgga?atactgacca?tctgggctag?cacgacctaa????120cagagggttc?tgcaggatgt?gctattttaa?agcagctggg?tgcaacttgt?gaaaacggga????180atctngaagc?agaacatgtn?atcagcgatg?gctgggattg?gtggacagga?ttgacaggag????240tatttgaggc?tctaccaggc?ctgtctacag?gacagcttca?tcgaagggac?attttttaac????300ctgttatttt?anatnccaca?tatntttttt?aatgctnaag?catacaggtt?gaatttctgg????360atcgtaacta?ctagtgactt?ctgaggttta?cagttngaat?atgttctcnn?aggtttatca????420agttntgtta?ttgatgatng?gtaatctaca?cctctggaag?ctgtngaatg?tgaaaaagat????480ncntncanct?gaccagtttg?nagggcactc?tcttctggna?agnaatccgn?ccaaaaaaat????540tgtttcnagg?gggcntgggg?ggtttaaaaa?aatgtttctn?ttnccntaaa?aatgtttacc????600cnnctattga?aaaaatgggg?gtcgnggggg?gcttnaaatc?cccnanttnt?gaatnttnta????660tccggaanct?tggtttccc?????????????????????????????????????????????????679

<210>6

<211>369

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(369)

＜223〉n=A, T, C or G

<400>6tcagtccagt?catgggtcct?ataagagaag?tcactctgtg?agtttccatg?gaggaagaaa?????60aagcttcatt?tctttaccct?gcagcaacag?cggagggagg?gagagcctat?cttctttgca????120aattcattaa?ctttgtggtt?gaagggagca?gcgtcngaaa?ctgctttagc?acagtgggag????180gaaaacaaac?agattcatct?ccggaaacca?aaggaaaggg?tragtgggtt?tttattagcc????240agctgtatcc?tagatggtca?atttccagtg?gatgaataca?ccttacgtac?gtttctcttg????300cttcctacct?nggcctgatc?agctnggcac?ttraatcatt?ccgtnggggt?wgctgtnaca????360ctggactga????????????????????????????????????????????????????????????369

<210>7

<211>264

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(264)

＜223〉n=A, T, C or G

<400>7tgctggatra?gggatggggc?acgggagcac?agatmgactt?taactgcccc?cacgttntcm?????60aggaaaggat?tacaggcgtg?agccactgcg?cccggcctct?tctccacttt?cataggttcc????120agtctctggt?tcttctttct?cagtttgttg?tttttgcttc?ttaaatmatg?gagatnagaa????180tgaacactac?actcggaatc?aggaagccct?gcctggcgcc?tctgtcacct?gtctaggggc????240ttcttctcac?tgagtcatcc?agca????????????????????????????????????????????264

<210>8

<211>280

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(280)

＜223〉n=A, T, C or G

<400>8acctcaactg?cccanaacan?aactgttgta?caagatttga?ggatttaaca?atatttcaca?????60tgaaatattt?cagacctacg?ngagggctta?aagacnaatt?aaatgagcac?cngtgtgccc????120accgccccna?ttaagaatta?gagcaagcag?tgaggtgaag?ccttgtcctt?gcttttaaca????180tagaaagtga?tccaaattca?ccaaacttga?cttnnggttt?tgcagtgtgg?cctcctgatt????240ctagacnctg?gcgaaacatt?tgatgggcaa?aaaaaaaaaa??????????????????????????280

<210>9

<211>449

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(449)

＜223〉n=A, T, C or G

<400>9tcgtcaactc?caggatggct?ttgaaaatna?atggacacag?atctctcctg?ttttgatrat?????60ntgcagtgct?natgactggc?tttgcagttn?attttgattc?aggcaacaga?tgttcctttt????120ggttccctgt?ctcccatggg?cgtcatttca?tgttgtcctc?tgccttcccc?cagatattct????180aagttcagga?cacaagcttc?tggcccatgc?agagcagagg?ccatgagggg?tcacagcatg????240ggtacgggag?gaaacactgg?gctnacccag?atnctggact?tgagtcttgc?ctctgctgct????300tgctgcacag?cttctgtcat?ggtgctaaac?ctgtgacctg?cctcacaggc?ttagagcatg????360cccgtagaag?tactctnaac?taaratgctt?tccacaaatg?agatggtttc?atgaaaactt????420caaatagagg?gcctgggcaa?aaaaaaaaa??????????????????????????????????????449

<210>10

<211>538

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(538)

＜223〉n=A, T, C or G

<400>10tttttttttt?ttcccaaagg?cctcaraaca?ctagtcttct?aattccaagc?agaaagttac?????60atccgccggg?atacatgcca?cttggtttga?taaatcaaaa?tacagcatcc?ttcagatccc????120tttgctgagc?aatacaatta?tttgtatatg?ttactttttt?ttctgtttgg?ctnaaagatt????180tgatatgagc?tgaggaaaat?gaagccntta?ctgctatnag?atctnatccc?tttccaccac????240ctttcaggga?tnttggcact?gcayatattc?agaattcccc?nnagtcgctn?gtgataaaaa????300tgtcttcaga?gatggcagaa?tatgtttcct?ttggtacatg?ttcattaaaa?atatacacgt????360gctcactact?gtggatatgt?atgtnttgac?cgatnacaca?ggctgattta?gggaagagat????420aaaagcacac?ttngaattta?ttagcctttc?accnagacta?anattctgaa?attaagaatg????480tattccttgg?tcaacaattt?tcctcttctc?ttagccctct?tacattgtan?tggactga??????538

<210>11

<211>543

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(543)

＜223〉n=A, T, C or G

<400>11tttttttttt?ttgcccacag?ctgccatctt?tgtgtgataa?ggccaacctt?ctatgggaat?????60caaccctcgc?catcccagca?aatcccctct?ctcccttctc?atgggagtgc?cttgtattca????120tcaggcatct?gggacttgat?gtgggtntgg?gatttgaaat?cagagcacct?nggtctctst????180caccattctn?tcacttatta?gctctnacct?tgggtnaata?cctgccttag?tgtcntaggt????240acaatatgaa?tattgtctat?ttctcaggga?ttgcaatgac?nagtnnatna?gtgcatgaga????300gggtaaaacc?acagggtact?ccgctcctcc?naagaatgga?gaattttttc?tagaagccca????360natntgcttg?gaaggttggc?caccnagagc?cnnaatcttc?ttttatttnc?cactgaangc????420ctaagaggna?attctgaact?catccccnna?tgacctctcc?cgaatmagaa?tatctctggc????480acttaccata?ttttcttgcc?ctcttccact?tacnaaactc?ctttattcct?taacnggacg????540aaa??????????????????????????????????????????????????????????????????543

<210>12

<211>329

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>12cgatgacttg?ggcagtgagt?gggcctcctg?ccaggtggca?gggcacagct?tagaccaaac?????60ccttggcctc?ccccctctgc?agstacctct?gaccaagaag?gaaactagca?agcctatgct????120ggcaagacca?taggtggggt?gctgggaatc?ctcggggccg?gctggcaccc?actcctggtg????180ctcaagggag?agacccactt?gttcagatgc?atrggcctca?ggcggttcaa?ggcrgtctta????240gagccacaga?gtcaaataaa?aatcaatttt?gagagaccac?agcacctgct?gctttgatcg????300tgatgttcaa?ggcaagttgc?aagtcatcg??????????????????????????????????????329

<210>13

<211>314

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(314)

＜223〉n=A, T, C or G

<400>13cgatgacttg?cacccgggag?ctgtgacagt?ggcctggaag?cagatggcag?ccccgtcaag?????60gcgggagtgg?agaccaccaa?accctccaaa?cagagcaaca?actagtacgc?ggccagcagc????120tacctgagcc?tgacgcccga?gcagtggaag?tcccacagaa?gctacagctg?ccaggtcacg????180catgaaggga?gcaccgtgga?gaagacagtg?gcccctacag?aatgttcata?ggttcccnac????240tctnacccca?cccacgggag?cctgganctg?cangatcccg?ggggaagggt?ctctctcccc????300atcccaagtc?atcg??????????????????????????????????????????????????????314

<210>14

<211>691

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(691)

＜223〉n=A, T, C or G

<400>14cgattacttg?cacaatgcan?attagaaccc?aaatgaaggg?tacaacccag?atcttctggc?????60ttccagttca?gtgctgctgg?gtttttctta?ctaaaccaaa?acaatkaaga?gcatagaagg????120gaagagaaga?ataaagtcta?ttttggtctt?tggtagcchg?ggtaangaga?atgctstcac????180tctacnagaa?aacccnaagt?gaacccggct?aatcaggacc?gtgcttggga?agggagcagg????240ggcattacct?ttcaacacca?gaggttcttt?gccttctctc?tgcagggact?cgargactat????300gtgaagtggc?tgggarggca?tcactcggct?tggttcattg?gtrttctcat?cataaactat????360natttctttg?gaaaaagatc?ctcttgaaag?artccttgcc?ttccctacag?gaaatcaagt????420ctaggacagt?gatcttgccc?ctgcttgcas?tctccgccgg?ctgatcttat?csgscccagt????480tkatgtgsam?cgctccttgg?atrtkactct?tgttttwctc?cvaggaaggg?gcytgcmagt????540ccnwtnaatg?amssgggccc?ttaactccgg?scrggtnamy?ncttgsctsc?rattttgggt????600ycytcttcyt?ttgsccmggt?tcktcnaaac?cacttngttr?aattccccgg?sccgcctkgc????660nggtycaacc?wttttgggaa?mamcyccccc?c???????????????????????????????????691

<210>15

<211>355

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(355)

＜223〉n=A, T, C or G

<400>15acctgaactg?tgtgttgaag?agtgatgtcc?tgctgcctgg?agctcaagtc?actactgatg?????60accgtgccta?tgtccgacag?ctagttncct?ccatggatgt?gactgagacc?aatgtcttct????120tcyaccctcg?gctcttacct?ttgacnaagt?ctcccgttga?gagtactacc?gaaccaccag????180cagttcgagc?ctctnaagag?cgtctaagcg?atggggatat?atatttactg?gagaatgggc????240tcaacctctt?cctctgggtg?ggagcaagcg?tccagcaggg?tgttgtccag?agccttttca????300gcgtctcctc?cttcagtcag?atcaccagtg?gtntgagtgt?tctgccagtt?caggt?????????355

<210>16

<211>522

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(522)

＜223〉n=A, T, C or G

<400>16tcagtccagt?gaggtggaag?acttcgaggc?tcgtgggagc?cgcttctcca?agtctgctga?????60tgagagacag?cgcatgctgg?tgcagcgtan?ggacgaactc?ctccagcaag?ctcgcagacg????120tttcttgaac?aaaagttctg?aagatgatgc?ggcctcagag?agcttcctcc?cctcggaagg????180tgcgtcctct?gaccccgtga?ccctncgtcg?aangatgctg?gctgccgccg?cggaacggan????240gcttcagaag?cagcagacct?cctngcgctc?ccttgccttc?ctcagctgcc?tcctgcgccc????300tgtgcccggc?tgactggagg?aggcctgtcc?aattctgccc?gccccatgga?aaagcgggct????360tgactgcatt?gccgctgtat?naaagcatgt?ggtcttacag?tgttnggacn?gctnatnaat????420ttnatcctnc?tntgtaatac?ttcctatgtg?acatttctct?tccccttgga?aacactgcan????480attttaactg?tgagtttgat?ctcttctngt?gttactggac?tg????????????????????????522

<210>17

<211>317

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>17gtgtcgcgaa?ttcgcggtgg?tgctaagaaa?aggaagaaga?agtcttacac?cactcccaag?????60aaggataagc?accagagaaa?gaaggttcag?ccggccgtcc?tgaaatatta?taaggtggat????120gagaatggca?aaattagttg?ccttcgtcga?gagtgcccct?ctgatgaatg?tggtgctggg????180gtgtttatgg?caagtcactt?tgacagacat?tattgtggca?aatgttgtct?gacccactgt????240ttcaactaac?cagaagacaa?gtaactgtat?gagttaatta?aagacatgaa?ctaaaaaaaa????300aaaaaaaaaa?actcgag???????????????????????????????????????????????????317

<210>18

<211>392

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>18tggagatttc?taatgaggtg?aggaagttcc?gtacattgac?agaattgatc?ctcgatgctc?????60aggaacatgt?taaaaatcct?tacaaaggca?aaaaactcaa?gaaacaccca?gacttcccca????120agaagcccct?gaccccttat?ttccgcttct?tcatggagaa?gcgggccaag?tatgcgaaac????180tccaccctca?gatgagcaac?ctggacctga?ccaagattct?gtccaagaaa?tacaaggagc????240ttccggagaa?gaagaagatg?aaatatgttc?cggacttcca?gagaagagaa?acaggagttc????300gagcgaaacc?tggcccgatt?cagggaggat?cacccccacc?ttatccagaa?tgccaagaat????360cggacatccc?agagaagccc?caagaccccc?cg??????????????????????????????????392

<210>19

<211>2624

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>19gaaacagtga?gaaggagatt?cctgtgctca?atgagctgcc?agtccccatg?gtggcccgct??????60acattcgcat?aaaccctcag?tcctggtttg?ataacgggag?catctgcatg?aggatggaga?????120tcttgggctg?cccactgccg?gatcctaata?actattatca?ccgacgtaat?gagatgacca?????180ccacggatga?cctggatttt?aagcaccaca?actattagga?aatgcgccag?ttgatgaagg?????240ttgtcaatga?aatgtgcccc?aatattacca?ggatttacaa?cattggcaaa?agccaccagg?????300gcctgaaatt?gtatgcggta?gagatctctg?accatcctgg?ggaacatgaa?gttggtgagc?????360ccgagttcca?ctacatcgca?ggggcccacg?gcaatgaggt?tctgggacga?gaactgctgc?????420tgctgctgct?gcacttcctc?tgccaggaat?actcggcgca?gaacgcacgc?atcgtccgct?????480tggtggagga?gactcgaatc?cacattctac?cctccctcaa?tcctgatggc?tatgagaagg?????540cctatgaagg?aggttccgag?ttgggaggct?ggtccctggg?acgttggacc?catgatggca?????600tcgatatcaa?caacaacttt?ccggatttaa?actcgctgct?ctgggaggca?gaggaccagc?????660agaatgcccc?aaggaaggtc?cccaaccact?acattgccat?ccctgagtgg?tttctgtctg?????720agaatgccac?agtggccaca?gagaccagag?ccgtcatcgc?ctggatggag?aagatcccgt?????780ttgtgctggg?aggcaaccta?caggggggtg?agctggtcgt?ggcatacccc?tatgacatgg?????840tgcggtccct?gtggaagacc?caggagcaca?ccccaacacc?tgatgatcat?gtgttccgct?????900ggctggcgta?ttcctacgcc?tccactcacc?gcctcatgac?agatgccagg?aggcgagtgt?????960gccacacgga?agattttcag?aaggaggagg?gcaccgtcaa?tggggcttcc?tggcacacag????1020tggctggaag?tctaaacgat?ttcagctacc?tccatacaaa?ctgctttgag?ctgtccatct????1080acgtgggctg?tgataaatac?ccacacgaga?gcgagctgcc?ggaggaatgg?gagaataacc????1140gggagtctct?gattgtgttc?atggagcagg?ttcatcgagg?catcaaaggc?atagtgagag????1200atttacaagg?gaaagggatt?tcaaatgctg?tcatctctgt?ggaaggtgtt?aaccatgaca????1260tccggacagc?cagcgatggg?gattactggc?gtctactgaa?ccctggcgaa?tatgtggtca????1320cagccaaggc?ggaaggcttt?atcacttcca?ccaagaactg?catggttggc?tatgatatgg????1380gagctactcg?gtgtgacttc?accctcacaa?agaccaacct?ggctaggata?agagaaatta????1440tggagacatt?tgggaagcag?cctgtcagcc?taccctccag?gcgcctgaag?ctgcggggac????1500ggaaaaggcg?gcagcgtggg?tgaccctgtc?ggacacttga?gacatacccc?agaccgtgca????1560aataaaaatc?cactccagta?gtaactctgt?agcaggcttt?ccctgttgtt?ttgactgtaa????1620ttcaagagac?actcaggagc?atacctgcat?ggcttggctg?accccaaagg?ggagggctgg????1680tggctcaggg?tgttttgttt?tttgtttttt?gttttttcct?ttgttctcat?ttatccaaat????1740accttgaaca?gagcagcaga?gaaaggccgg?tggcagtgag?ggaattaatt?cagtgagtca????1800gtctgagatt?ctaaaaaggg?tgcttgacca?ctggccagga?agggaaatca?ggccttcccc????1860catttgcgtg?acattcaagc?ttcccagtgc?atttgcaagt?ggcacagttg?acattgcagc????1920acccagggaa?tcctttgccc?cagatgttat?catttgagat?gctcttatgc?agcctaagaa????1980aatccatcct?ctctggcccc?aggggacaag?ccaagctgct?atgtacacac?tcggtgttct????2040attgacaata?gaggcattta?ttaccaagtg?tgcatcgctg?agtcctaaat?cagctctgtt????2100cctttttcca?acaaagcttg?tcttcctaag?agcagacaga?agtggagagc?acccaagaat????2160gagtgctggg?cagcagaccc?tgggggaggg?ggcttgctat?cccagaaagc?ccctaaaccc????2220tttgctgctc?cattagccct?ggggtgagga?gagccagaca?tgttaggagg?ccagagcagt????2280cagtcagggc?atcttggaaa?agaccttgaa?ggaagcaaac?cctgggttcc?ttttgctcca????2340gaatgtgaga?gctccaagtt?ggccccaatc?aggaggggag?taatgatgaa?catacagacg????2400gccacatctt?gccaatcaag?catcatctga?tgaaaaagaa?agcaatctta?ggattacctg????2460ggacacgtca?gtctgggaga?ggtggttgaa?tcattgtgta?agggaatagt?gtatctaatc????2520tgtgttgatc?ctgctgcctt?gttgacctgg?agagaatgaa?acaaacaaac?acataaacaa????2580ataaagcaaa?tggtaagatt?aaaaaaaaaa?aaaaaaaact?cgag?????????????????????2624

<210>20

<211>488

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>20ctttcaaccc?gcgctcgccg?gctccagccc?cgcgcgcccc?caccccttgc?cctcccggcg?????60gctccgcagg?gtgaggtggc?tttgaccccg?ggttgcccgg?ccagcacgac?cgaggaggtg????120gctggacagc?tggaggatga?acggagaagc?cgactgcccc?acagacctgg?aaatggccgc????180ccccagaggc?caagaccgtt?ggtcccagga?agacatgctg?actttgctgg?aatgcatgaa????240gaacaacctt?ccatccaatg?acagctccca?gttcaaaacc?acccaaacac?acatggaccg????300ggaaaaagtt?gcattgaaag?acttttctgg?agacatgtgc?aagctcaaat?gggtcgagat????360ctctaatgag?gtgaggaagt?tccgtacatt?gacagaattg?atcctcgata?ctcaggaaca????420tgtttaaaat?ccttacaaag?gcaaaaaatc?aagaaacacc?ccgacttccc?cgagaaagcc????480cctaaccc?????????????????????????????????????????????????????????????488

<210>21

<211>391

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>21atggaattgt?ggttttctct?ttgggatcaa?tggtctcaga?aattccagag?aagaaagctg?????60tggcgattgc?tgatgctttg?ggcaaaatcc?ctcagacagt?cctgtggcgg?tacactggaa????120cccgaccatc?gaatcttgcg?aacaacacga?tacttgttca?gtggctaccc?caaaacgatc????180tgcttggtca?cccaatgacc?cgtgccttta?tcacccatgc?tagttcccat?ggtgttaatg????240aaagcatatg?caatggcgtt?cccatggtga?tgataccctt?atttggtgat?cagatggaca????300atgcaaagcg?cagggagact?aagggagctg?gagtgaccct?gaatgttctg?gagatgactt????360ctgaagatct?agaagatgct?ctgaagagca?g???????????????????????????????????391

<210>22

<211>1320

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>22aatctgctgg?gaatttcttg?ggttgacagc?tcttggatcc?ctattttgaa?cagtggtagt??????60gtcctggatt?acttttcaga?aagaagtaat?cctttttatg?acagaacatg?taataatgaa?????120gtggtcaaaa?tgcagaggct?aacattagaa?cacttgaatc?agatggttgg?aatcgagtac?????180atccttttgc?atgctcaaga?gcccattctt?ttcatcattc?ggaagcaaca?gcggcagtcc?????240cctgcccaag?ttatcccact?agctgattac?tatatcattg?ctggagtgat?ctatcaggca?????300ccagacttgg?gatcagttat?aaactctaga?gtgcttactg?cagtgcatgg?tattcagtca?????360gcttttgatg?aagctatgtc?atactgtcga?tatcatcctt?ccaaagggta?ttggtggcac?????420ttcaaagatc?atgaagagca?agataaagtc?agacctaaag?ccaaaaggaa?agaagaacca?????480agctctattt?ttcagagaca?acgtgtggat?gctttacttt?tagacctcag?acaaaaattt?????540ccacccaaat?ttgtgcagct?aaagcctgga?gaaaagcctg?ttccagtgga?tcaaacaaag?????600aaagaggcag?aacctatacc?agaaactgta?aaacctgagg?agaaggagac?cacaaagaat?????660gtacaacaga?cagtgagtgc?taaaggcccc?cctgaaaaac?ggatgagact?tcagtgagta?????720ctggacaaaa?gagaagcctg?gaagactcct?catgctagtt?atcatacctc?agtactgtgg?????780ctcttgagct?ttgaagtact?ttattgtaac?cttcttattt?gtatggaatg?cgcttatttt?????840ttgaaaggat?attaggccgg?atgtggtggc?tcacgcctgt?aatcccagca?ctttgggagg?????900ccatggcggg?tggatcactt?gaggtcagaa?gttcaagacc?agcctgacca?atatggtgaa?????960accccgtctc?tactaaaaat?acaaaaatta?gccgggcgtg?gtggcgggcg?cccatagtcc????1020cagctactcg?ggaggctgag?acaggagact?tgcttgaacc?cgggaggtgg?aggttgccct????1080gagctgatca?tcctgctgtt?gcactccagc?ttgggcgaaa?gagcgagact?ttgtctctat????1140aaagaaggaa?agatattatt?cccatcatga?tttcttgtga?atatttgtaa?tatgtttttt????1200gtaacctttc?ctttcccgga?cttgagcaac?ctacacactc?acatgtttaa?tggtagatat????1260gttttaaagc?aagataaagg?tattggtttt?aaaaaaaaaa?aaaaaaaaaa?aaaactcgag????1320

<210>23

<211>633

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>23ctaagggcag?tgaaggtgaa?aaccctctca?cggtcccagg?gagggagaag?gaaggcatgc?????60tgatgggggt?taagccgggg?gaggacgcat?cggggcctgc?tgaagacctt?gtgagaagat????120ctgagaaaga?tactgcagct?gttgtctcca?gacagggcag?ctccctgaac?ctctttgaag????180atgtgcagat?cacagaacca?gaagctgagc?cagagtccaa?gtctgaaccg?agacctccaa????240tttcctctcc?gagggctccc?cagaccagag?ctgtcaagcc?ccgacttcat?cctgtgaagc????300caatgaatgc?cacggccacc?aaggttgcta?actgcagctt?gggaactgcc?accatcatcg????360gtgagaactt?gaacaatgag?gtcatgatga?agaaatacag?cccctcggac?cctgcatttg????420catatgcgca?gctgacccac?gatgagctga?ttcagctggt?cctcaaacag?aaggaaacga????480taagcaagaa?ggagttccag?gtccgcgagc?tggaagacta?cattgacaac?ctgctcgtca????540gggtcatgga?agaaaccccc?aatatcctcc?gcatcccgac?tcaggttggc?aaaaaagcag????600gaaagatgta?aattagcaga?aaaaaaactc?gag?????????????????????????????????633

<210>24

<211>1328

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>24gtaaacgctc?tcggaattat?ggcggcggtg?gatatccgag?acaatctgct?gggaatttct??????60tgggttgaca?gctcttggat?ccctattttg?aacagtggta?gtgtcctgga?ttacttttca?????120gaaagaagta?atccttttta?tgacagaaca?tgtaataatg?aagtggtcaa?aatgcagagg?????180ctaacattag?aacacttgaa?tcagatggtt?ggaatcgagt?acatcctttt?gcatgctcaa?????240gagcccattc?ttttcatcat?tcggaagcaa?cagcggcagt?cccctgccca?agttatccca?????300ctagctgatt?actatatcat?tgctggagtg?atctatcagg?caccagactt?gggatcagtt?????360ataaactcta?gagtgcttac?tgcagtgcat?ggtattcagt?cagcttttga?tgaagctatg?????420tcatactgtc?gatatcatcc?ttccaaaggg?tattggtggc?acttcaaaga?tcatgaagag?????480caagataaag?tcagacctaa?agccaaaagg?aaagaagaac?caagctctat?ttttcagaga?????540caacgtgtgg?atgctttact?tttagacctc?agacaaaaaa?tttccaccca?aatttgtgca?????600gtggatcaaa?caaagaaaga?ggcagaacct?ataccagaaa?ctgtaaaacc?tgaggagaag?????660gagaccacaa?agaatgtaca?acagacagtg?agtgctaaag?gcccccctga?aaaacggatg?????720agacttcagt?gagtactgga?caaaagagaa?gcctggaaga?ctcctcatgc?tagttatcat?????780acctcagtac?tgtggctctt?gagctttgaa?gtactttatt?gtaaccttct?tatttgtatg?????840gaatgcgctt?atttttttga?aaggatatta?ggccggatgt?ggtggctcac?gcctgtaatc?????900ccagcacttt?gggaggccat?ggcgggtgga?tcacttgagg?tcagaagttc?aagaccagcc?????960tgaccaatat?ggtgaaaccc?cgtctctact?aaaaatacaa?aaattagccg?ggcgtggtgg????1020cgggcgccca?tagtcccagc?tactcgggag?gctgagacag?gagacttgct?tgaacccggg????1080aggtggaggt?tgccctgagc?tgattatcat?gctgttgcac?tccagcttgg?gcgacagagc????1140gagactttgt?ctcaaaaaag?aagaaaagat?attattccca?tcatgatttc?ttgtgaatat????1200ttgtgatatg?tcttctgtaa?cctttcctct?cccggacttg?agcaacctac?acactcacat????1260gtttactggt?agatatgttt?aaaagcaaaa?taaaggtatt?tgtataaaaa?aaaaaaaaaa????1320aaactcga?????????????????????????????????????????????????????????????1328

<210>25

<211>1758

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>25gttttttttt?tttttttttt?aaagagttgc?aacaattcat?ctttatttct?tattttcctc??????60tggagatgca?gaatttggta?tatttcaccc?caagtatatt?tgggatagtt?ggctcctcgc?????120tgggtcagga?tggctgggtg?ccttctcccc?tggcatggtt?ctcttctctg?cagggcgagg?????180ggcagggagc?tagtaaaacc?tcgcaatgac?agccgcaatg?gcagacccaa?tggagcccag?????240gatgaacttg?gtcaatccgg?agagtccagt?tgctcccagt?gactgcagag?tagccacaag?????300gctgcccgag?gcaactccac?ccccattggc?aatggccgcc?gcggacatca?tcttggctgc?????360tatggaggac?gaggcgattc?ccgccgcagt?gaagcccatg?gcactgagtg?gcggcggtgg?????420atatccgaga?caatctgctg?ggaatttctt?gggttgacag?ctcttggatc?cctattttga?????480acagtggtag?tgtcctggat?tacttttcag?aaagaagtaa?tcctttttat?gacagaacat?????540gtaataatga?agtggtcaaa?atgcagaggc?taacattaga?acacttgaat?cagatggttg?????600gaatcgagta?catccttttg?catgctcaag?agcccattct?tttcatcatt?cggaagcaac?????660agcggcagtc?ccctgcccaa?gttatcccac?tagctgatta?ctatatcatt?gctggagtga?????720tctatcaggc?accagacttg?ggatcagtta?taaactctag?agtgcttact?gcagtgcatg?????780gtattcagtc?agcttttgat?gaagctatgt?catactgtcg?atatcatcct?tccaaagggt?????840attggtggca?cttcaaagat?catgaagagc?aagataaagt?cagacctaaa?gccaaaagga?????900aagaagaacc?aagctctatt?tttcagagac?aacgtgtgga?tgctttactt?ttagacctca?????960gacaaaaatt?tccacccaaa?tttgtgcagc?taaagcctgg?agaaaagcct?gttccagtgg????1020atcaaacaaa?gaaagaggca?gaacctatac?cagaaactgt?aaaacctgag?gagaaggaga????1080ccacaaagaa?tgtacaacag?acagtgagtg?ctaaaggccc?ccctgaaaaa?cggatgagac????1140ttcagtgagt?actggacaaa?agagaagcct?ggaagactcc?tcatgctagt?tatcatacct????1200cagtactgtg?gctcttgagc?tttgaagtac?tttattgtaa?ccttcttatt?tgtatggaat????1260gcgcttattt?tttgaaagga?tattaggccg?gatgtggtgg?ctcacgcctg?taatcccagc????1320actttgggag?gccatggcgg?gtggatcact?tgaggtcaga?agttcaagac?cagcctgacc????1380aatatggtga?aaccccgtct?ctactaaaaa?tacaaaaatt?agccgggcgt?ggtggcgggc????1440gcccatagtc?ccagctactc?gggaggctga?gacaggagac?ttgcttgaac?ccgggaggtg????1500gaggttgccc?tgagctgatt?atcatgctgt?tgcactccag?cttgggcgac?agagcgagac????1560tttgtctcaa?aaaagaagaa?aagatattat?tcccatcatg?atttcttgtg?aatatttgtt????1620atatgtcttc?tgttaccttt?cctctcccgg?aattgagcaa?cctacacact?cacatgttta????1680ctggtagata?tgtttaaaag?caaataaagg?tattggtata?tattgcttca?aaaaaaaaaa????1740aaaaaaaaaa?aactcgag??????????????????????????????????????????????????1758

<210>26

<211>493

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>26gaggcgagcg?gcagggcctg?gtggcgagag?cgcggctgtc?actgcgcccg??agcatcccag?????60agctttccga?gcggacgagc?cggccgtgcc?gggcatcccc?agcctcgcta??ccctcgcagc????120acacgtcgag?ccccgcacag?gcaagggtcc?ggaacttagc?ccaaagcacg?tttcccctgg????180cagcgcagga?gacgcccggc?cgcgcgccgg?cgcacgcccc?cctctcctcc?tttgttccgg????240gggtcggcgg?ccgctctcct?gccagcgtcg?ggatctcggc?cccgggaggc?gggccgtcgg????300gcgcagccgc?gaagattccg?ttggaactga?cgcagagccg?agtgcagaag?atctgggtgc????360ccgtggacca?caggccctcg?ttgcccagat?cctgtgggcc?aaagctgacc?aactcccccg????420ccgtcttcgt?catggtgggc?ctcccccgcc?cggggcaaga?cctacttctc?cacgaaagct????480tactcgctgc?ctc???????????????????????????????????????????????????????493

<210>27

<211>1331

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>27ggtggatatc?cgagacaatc?tgctgggaat?ttcttgggtt?gacagctctt?ggatccctat??????60tttgaacagt?ggtagtgtcc?tggattactt?ttcagaaaga?agtaatcctt?tttatgacag?????120aacatgtaat?aatgaagtgg?tcaaaatgca?gaggctaaca?ttagaacact?tgaatcagat?????180ggttggaatc?gagtacatcc?ttttgcatgc?tcaagagccc?attcttttca?tcattcggaa?????240gcaacagcgg?cagtcccctg?cccaagttat?cccactagct?gattactata?tcattgctgg?????300agtgatctat?caggcaccag?acttgggatc?agttataaac?tctagagtgc?ttactgcagt?????360gcatggtatt?cagtcagctt?ttgatgaagc?tatgtcatac?tgtcgatatc?atccttccaa?????420agggtattgg?tggcacttca?aagatcatga?agagcaagat?aaagtcagac?ctaaagccaa?????480aaggaaagaa?gaaccaagct?ctatttttca?gagacaacgt?gtggatgctt?tacttttaga?????540cctcagacaa?aaatttccac?ccaaatttgt?gcagctaaag?cctggagaaa?agcctgttcc?????600agtggatcaa?acaaagaaag?aggcagaacc?tataccagaa?actgtaaaac?ctgaggagaa?????660ggagaccaca?aagaatgtac?aacagacagt?gagtgctaaa?ggcccccctg?aaaaacggat?????720gagacttcag?tgagtactgg?acaaaagaga?agcctggaag?actcctcatg?ctagttatca?????780tacctcagta?ctgtggctct?tgagctttga?agtactttat?tgtaaccttc?ttatttgtat?????840ggaatgcgct?tattttttga?aaggatatta?ggccggatgt?ggtggctcac?gcctgtaatc?????900ccagcacttt?gggaggccat?ggcgggtgga?tcacttgagg?tcagaagttc?aagaccagcc?????960tgaccaatat?ggtgaaaccc?cgtctctact?aaaaatacaa?aaattagccg?ggcgtggtgg????1020cgggcgccca?tagtcccagc?tactcgggag?gctgagacag?gagacttgct?tgaacccggg????1080aggtggaggt?tgccctgagc?tgattatcat?gctgttgcac?tccagcttgg?gcgacagagc????1140gagactttgt?ctcaaaaaaa?gaagaaaaga?tattattccc?atcatgattt?cttgtgaata????1200tttgttatat?gtcttctgta?acctttcctc?tcccggactt?gagcaaccta?cacactcaca????1260tgtttactgg?tagatatgtt?taaaagcaaa?ataaaggtat?tggtataaaa?aaaaaaaaaa????1320aaaaactcga?g?????????????????????????????????????????????????????????1331

<210>28

<211>1333

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>28cggcggtgga?tatccgagac?aatctgctgg?gaatttcttg?ggttgacagc?tcttggatcc??????60ctattttgaa?cagtggtagt?gtcctggatt?acttttcaga?aagaagtaat?cctttttatg?????120acagaacatg?taataatgaa?gtggtcaaaa?tgcagaggct?aacattagaa?cacttgaatc?????180agatggttgg?aatcgagtac?atccttttgc?atgctcaaga?gcccattctt?ttcatcattc?????240ggaagcaaca?gcggcagtcc?cctgcccaag?ttatcccact?agctgattac?tatatcattg?????300ctggagtgat?ctatcaggca?ccagacttgg?gatcagttat?aaactctaga?gtgcttactg?????360cagtgcatgg?tattcagtca?gcttttgatg?aagctatgtc?atactgtcga?tatcatcctt?????420ccaaagggta?ttggtggcac?ttcaaagatc?atgaagagca?agataaagtc?agacctaaag?????480ccaaaaggaa?agaagaacca?agctctattt?ttcagagaca?acgtgtggat?gctttacttt?????540tagacctcag?acaaaaattt?ccacccaaat?ttgtgcagct?aaagcctgga?gaaaagcctg?????600ttccagtgga?tcaaacaaag?aaagaggcag?aacctatacc?agaaactgta?aaacctgagg?????660agaaggagac?cacaaagaat?gtacaacaga?cagtgagtgc?taaaggcccc?cctgaaaaac?????720ggatgagact?tcagtgagta?ctggacaaaa?gagaagcctg?gaagactcct?catgctagtt?????780atcatacctc?agtactgtgg?ctcttgagct?ttgaagtact?ttattgtaac?cttcttattt?????840gtatggaatg?cgcttatttt?ttgaaaggat?attaggccgg?atgtggtggc?tcacgcctgt?????900aatcccagca?ctttgggagg?ccatggcggg?tggatcactt?gaggtcagaa?gttcaagacc?????960agcctgacca?atatggtgaa?accccgtctc?tactaaaaat?acaaaaatta?gccgggcgtg????1020gtggcgggcg?cccatagtcc?cagctactcg?ggaggctgag?acaggagact?tgcttgaacc????1080cgggaggtgg?aggttgccct?gagctgatta?tcatgctgtt?gcactccagc?ttgggcgaca????1140gagcgagact?ttgtctcaaa?aaagaagaaa?agatattatt?cccatcatga?tttcttgtga????1200atatttgtga?tatgtcttct?gtaacctttc?ctctcccgga?cttgagcaac?ctacacactc????1260acatgtttac?tggtagatat?gtttaaaagc?aaaataaagg?tatttgtata?aaaaaaaaaa????1320aaaaaaactc?gag???????????????????????????????????????????????????????1333

<210>29

<211>813

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>29ctgagctgca?cttcagcgaa?ttcacctcgg?ctgtggctga?catgaagaac?tccgtggcgg?????60accgagacaa?cagccccagc?tcctgtgctg?gcctcttcat?tgcttcacac?atcgggtttg????120actggcccgg?ggtctgggtc?cacctggaca?tcgctgctcc?agtgcatgct?ggcgagcgag????180ccacaggctt?tggggtggct?ctcctactgg?ctctttttgg?ccgtgcctcc?gaggacccgc????240tgctgaacct?ggtatccccg?ctggactgtg?aggtggatgc?ccaggaaggc?gacaacatgg????300ggcgtgactc?caagagacgg?aggctcgtgt?gagggctact?tcccagctgg?tgacacaggg????360ttccttacct?cattttgcac?tgactgattt?taagcaattg?aaagattaac?taactcttaa????420gatgagtttg?gcttctcctt?ctgtgcccag?tggtgacagg?agtgagccat?tcttctctta????480gaagcagctt?aggggcttgg?tggggtctgg?agaaaattgt?cacagacccc?ataggtctcc????540atctgtaagc?tctgtccctt?gtcctccacc?ctggtcttta?gagccacctc?aggtcaccct????600ctgtagtgag?tgtacttcct?gacccaggcc?cttgctcaag?ctggggctcc?ctggggtgtc????660taaccagccc?tgggtagatg?tgactggctg?ttagggaccc?cattctgtga?agcaggagac????720cctcacagct?cccaccaacc?cccagttcac?ttgaagttga?attaaatatg?gccacaacat????780aaaaaaaaaa?aaaaaaaaaa?aaaaaaactc?gag?????????????????????????????????813

<210>30

<211>1316

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>30caggcgccca?gtcatggccc?aagagacagc?accaccgtgt?ggcccagtct?caaggggtga??????60cagtccaatc?atagaaaaga?tggaaaaaag?gacatgtgcc?ctgtgccctg?aaggccacga?????120gtggagtcaa?atatactttt?caccatcagg?aaatatagtt?gctcatgaaa?actgtttgct?????180gtattcatca?ggactggtgg?agtgtgagac?tcttgatcta?cgtaatacaa?ttagaaactt?????240tgatgtcaaa?tctgtaaaga?aagagatctg?gagaggaaga?agattgaaat?gctcattctg?????300taacaaagga?ggcgccaccg?tggggtgtga?tttatggttc?tgtaagaaga?gttaccacta?????360tgtctgtgcc?aaaaaggacc?aagcaattct?tcaagttgat?ggaaaccatg?gaacttacaa?????420attattttgc?ccagaacatt?ctccagaaca?agaagaggcc?actgaaagtg?ctgatgaccc?????480aagcatgaag?aagaagagag?gaaaaaacaa?acgcctctca?tcaggccctc?ctgcacagcc?????540aaaaacgatg?aaatgtagta?acgccaaaag?acatatgaca?gaagagcctc?atggtcacac?????600agatgcagct?gtcaaatctc?cttttcttaa?gaaatgccag?gaagcaggac?ttcttactga?????660actatttgaa?cacatactag?aaaatatgga?ttcagttcat?ggaagacttg?tggatgagac?????720tgcctcagag?tcggactatg?aagggatcga?gaccttactg?tttgactgtg?gattatttaa?????780agacacacta?agaaaattcc?aagaagtaat?caagagtaaa?gcttgtgaat?gggaagaaag?????840gcaaaggcag?atgaagcagc?agcttgaggc?acttgcagac?ttacaacaaa?gcttgtgctc?????900atttcaagaa?aatggggacc?tggactgctc?aagttctaca?tcaggatcct?tgctacctcc?????960tgaggaccac?cagtaaaagc?tgttcctcag?gaaaactgga?tggggcctcc?atgttctcca????1020aggatcgagg?aagtcttcct?gcctaccctg?cccaccccag?tcaagggcag?caacaccaga????1080gctttgctca?gccttaaatg?gaatcttaga?gctttctctt?gcttctgcta?ctcctacaga????1140tggcctcatc?atggtctcca?ctcagtatta?ataactccat?cagcatagag?caaactcaac????1200actgtgcatt?gcacactgtt?accatgggtt?tatgctcact?atcatatcac?attgccaata????1260tttagcacac?ttaataaatg?cttgtcaaaa?cccaaaaaaa?aaaaaaaaaa?ctcgag????????1316

<210>31

<211>1355

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>31cggcggtgga?tatccgagac?aatctgctgg?gaatttcttg?ggttgacagc?tcttggatcc??????60ctattttgaa?cagtggtagt?gtcctggatt?acttttcaga?aagaagtaat?cctttttatg?????120acagaacatg?taataatgaa?gtggtcaaaa?tgcagaggct?aacattagaa?cacttgaatc?????180agatggttgg?aatcgagtac?atccttttgc?atgctcaaga?gcccattctt?ttcatcattc?????240ggaagcaaca?gcggcagtcc?cctgcccaag?ttatcccact?agctgattac?tatatcattg?????300ctggagtgat?ctatcaggca?ccagacttgg?gatcagttat?aaactctaga?gtgcttactg?????360cagtgcatgg?tattcagtca?gcttttgatg?aagctatgtc?atactgtcga?tatcatcctt?????420ccaaagggta?ttggtggcac?ttcaaagatc?atgaagagca?agataaagtc?agacctaaag?????480ccaaaaggaa?agaagaacca?agctctattt?ttcagagaca?acgtgtggat?gctttacttt?????540tagacctcag?acaaaaattt?ccacccaaat?ttgtgcagct?aaagcctgga?gaaaagcctg?????600ttccagtgga?tcaaacaaag?aaagaggcag?aacctatacc?agaaactgta?aaacctgagg?????660agaaggagac?cacaaagaat?gtacaacaga?cagtgagtgc?taaaggcccc?cctgaaaaac?????720ggatgagact?tcagtgagta?ctggacaaaa?gagaagcctg?gaagactcct?catgctagtt?????780atcatacctc?agtactgtgg?ctcttgagct?ttgaagtact?ttattgtaac?cttcttattt?????840gtatggaatg?cgcttatttt?ttgaaaggat?attaggccgg?atgtggtggc?tcacgcctgt?????900aatcccagca?ctttgggagg?ccatggcggg?tggatcactt?gaggtcagaa?gttcaagacc?????960agcctgacca?atatggtgaa?accccgtctc?tactaaaaat?acaaaaatta?gccgggcgtg????1020gtggcgggcg?cccatagtcc?cagctactcg?ggaggctgag?acaggagact?tgcttgaacc????1080cgggaggtgg?aggttgccct?gagctgatta?tcatgctgtt?gcactccagc?ttgggcgaca????1140gaacgagact?ttgtctcaaa?aaaagaagaa?aagatattat?tcccatcatg?atttcttgtg????1200aatatttgtt?atatgtcttc?tggtaacctt?tcctctcccg?gacttgaagc?aacctcacac????1260actcacatgt?ttactggtag?atatgtttta?aaagcaaaat?aaaggtattt?gtttttccaa????1320aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaac?tcgag???????????????????????????????1355

<210>32

<211>80

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>32Val?Ser?Arg?Ile?Arg?Gly?Gly?Ala?Lys?Lys?Arg?Lys?Lys?Lys?Ser?Tyr?1???????????????5??????????????????10??????????????????15Thr?Thr?Pro?Lys?Lys?Asp?Lys?His?Gln?Arg?Lys?Lys?Val?Gln?Pro?Ala

20??????????????????25??????????????????30Val?Leu?Lys?Tyr?Tyr?Lys?Val?Asp?Glu?Asn?Gly?Lys?Ile?Ser?Cys?Leu

35??????????????????40??????????????????45Arg?Arg?Glu?Cys?Pro?Ser?Asp?Glu?Cys?Gly?Ala?Gly?Val?Phe?Met?Ala

50??????????????????55??????????????????60Ser?His?Phe?Asp?Arg?His?Tyr?Cys?Gly?Lys?Cys?Cys?Leu?Thr?His?Cys65??????????????????70??????????????????75??????????????????80

<210>33

<211>130

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>33Glu?Ile?Ser?Asn?Glu?Val?Arg?Lys?Phe?Arg?Thr?Leu?Thr?Glu?Leu?Ile?1???????????????5??????????????????10??????????????????15Leu?Asp?Ala?Gln?Glu?His?Val?Lys?Asn?Pro?Tyr?Lys?Gly?Lys?Lys?Leu

20??????????????????25??????????????????30Lys?Lys?His?Pro?Asp?Phe?Pro?Lys?Lys?Pro?Leu?Thr?Pro?Tyr?Phe?Arg

35??????????????????40??????????????????45Phe?Phe?Met?Glu?Lys?Arg?Ala?Lys?Tyr?Ala?Lys?Leu?His?Pro?Gln?Met

50??????????????????55??????????????????60Ser?Asn?Leu?Asp?Leu?Thr?Lys?Ile?Leu?Ser?Lys?Lys?Tyr?Lys?Glu?Leu65??????????????????70??????????????????75??????????????????80Pro?Glu?Lys?Lys?Lys?Met?Lys?Tyr?Val?Pro?Asp?Phe?Gln?Arg?Arg?Glu

85??????????????????90??????????????????95Thr?Gly?Val?Arg?Ala?Lys?Pro?Gly?Pro?Ile?Gln?Gly?Gly?Ser?Pro?Pro

100?????????????????105?????????????????110Pro?Tyr?Pro?Glu?Cys?Gln?Glu?Ser?Asp?Ile?Pro?Glu?Lys?Pro?Gln?Asp

115?????????????????120?????????????????125Pro?Pro

130

<210>34

<211>506

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>34Asn?Ser?Glu?Lys?Glu?Ile?Pro?Val?Leu?Asn?Glu?Leu?Pro?Val?Pro?Met?1???????????????5??????????????????10??????????????????15Val?Ala?Arg?Tyr?Ile?Arg?Ile?Asn?Pro?Gln?Ser?Trp?Phe?Asp?Asn?Gly

20??????????????????25??????????????????30Ser?Ile?Cys?Met?Arg?Met?Glu?Ile?Leu?Gly?Cys?Pro?Leu?Pro?Asp?Pro

35??????????????????40??????????????????45Asn?Asn?Tyr?Tyr?His?Arg?Arg?Asn?Glu?Met?Thr?Thr?Thr?Asp?Asp?Leu

50??????????????????55??????????????????60Asp?Phe?Lys?His?His?Asn?Tyr?Lys?Glu?Met?Arg?Gln?Leu?Met?Lys?Val65??????????????????70??????????????????75??????????????????80Val?Asn?Glu?Met?Cys?Pro?Asn?Ile?Thr?Arg?Ile?Tyr?Asn?Ile?Gly?Lys

85??????????????????90??????????????????95Ser?His?Gln?Gly?Leu?Lys?Leu?Tyr?Ala?Val?Glu?Ile?Ser?Asp?His?Pro

100?????????????????105?????????????????110Gly?Glu?His?Glu?Val?Gly?Glu?Pro?Glu?Phe?His?Tyr?Ile?Ala?Gly?Ala

115?????????????????120?????????????????125His?Gly?Asn?Glu?Val?Leu?Gly?Arg?Glu?Leu?Leu?Leu?Leu?Leu?Leu?His

130?????????????????135?????????????????140Phe?Leu?Cys?Gln?Glu?Tyr?Ser?Ala?Gln?Asn?Ala?Arg?Ile?Val?Arg?Leu145?????????????????150?????????????????155?????????????????160Val?Glu?Glu?Thr?Arg?Ile?His?Ile?Leu?Pro?Ser?Leu?Asn?Pro?Asp?Gly

165?????????????????170?????????????????175Tyr?Glu?Lys?Ala?Tyr?Glu?Gly?Gly?Ser?Glu?Leu?Gly?Gly?Trp?Ser?Leu

180?????????????????185?????????????????190Gly?Arg?Trp?Thr?His?Asp?Gly?Ile?Asp?Ile?Asn?Asn?Asn?Phe?Pro?Asp

195?????????????????200?????????????????205Leu?Asn?Ser?Leu?Leu?Trp?Glu?Ala?Glu?Asp?Gln?Gln?Asn?Ala?Pro?Arg

210?????????????????215?????????????????220Lys?Val?Pro?Asn?His?Tyr?Ile?Ala?Ile?Pro?Glu?Trp?Phe?Leu?Ser?Glu225?????????????????230?????????????????235?????????????????240Asn?Ala?Thr?Val?Ala?Thr?Glu?Thr?Arg?Ala?Val?Ile?Ala?Trp?Met?Glu

245?????????????????250?????????????????255Lys?Ile?Pro?Phe?Val?Leu?Gly?Gly?Asn?Leu?Gln?Gly?Gly?Glu?Leu?Val

260?????????????????265?????????????????270Val?Ala?Tyr?Pro?Tyr?Asp?Met?Val?Arg?Ser?Leu?Trp?Lys?Thr?Gln?Glu

275?????????????????280?????????????????285His?Thr?Pro?Thr?Pro?Asp?Asp?His?Val?Phe?Arg?Trp?Leu?Ala?Tyr?Ser

290?????????????????295?????????????????300Tyr?Ala?Ser?Thr?His?Arg?Leu?Met?Thr?Asp?Ala?Arg?Arg?Arg?Val?Cys305?????????????????310?????????????????315?????????????????320His?Thr?Glu?Asp?Phe?Gln?Lys?Glu?Glu?Gly?Thr?Val?Asn?Gly?Ala?Ser

325?????????????????330?????????????????335Trp?His?Thr?Val?Ala?Gly?Ser?Leu?Asn?Asp?Phe?Ser?Tyr?Leu?His?Thr

340?????????????????345?????????????????350Asn?Cys?Phe?Glu?Leu?Ser?Ile?Tyr?Val?Gly?Cys?Asp?Lys?Tyr?Pro?His

355?????????????????360?????????????????365Glu?Ser?Glu?Leu?Pro?Glu?Glu?Trp?Glu?Asn?Asn?Arg?Glu?Ser?Leu?Ile

370?????????????????375?????????????????380Val?Phe?Met?Glu?Gln?Val?His?Arg?Gly?Ile?Lys?Gly?Ile?Val?Arg?Asp385?????????????????390?????????????????395?????????????????400Leu?Gln?Gly?Lys?Gly?Ile?Ser?Asn?Ala?Val?Ile?Ser?Val?Glu?Gly?Val

405?????????????????410?????????????????415Asn?His?Asp?Ile?Arg?Thr?Ala?Ser?Asp?Gly?Asp?Tyr?Trp?Arg?Leu?Leu

420?????????????????425?????????????????430Asn?Pro?Gly?Glu?Tyr?Val?Val?Thr?Ala?Lys?Ala?Glu?Gly?Phe?Ile?Thr

435?????????????????440?????????????????445Ser?Thr?Lys?Asn?Cys?Met?Val?Gly?Tyr?Asp?Met?Gly?Ala?Thr?Arg?Cys

450?????????????????455?????????????????460Asp?Phe?Thr?Leu?Thr?Lys?Thr?Asn?Leu?Ala?Arg?Ile?Arg?Glu?Ile?Met465?????????????????470?????????????????475?????????????????480Glu?Thr?Phe?Gly?Lys?Gln?Pro?Val?Ser?Leu?Pro?Ser?Arg?Arg?Leu?Lys

485?????????????????490?????????????????495Leu?Arg?Gly?Arg?Lys?Arg?Arg?Gln?Arg?Gly

500?????????????????505

<210>35

<211>96

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>35Met?Asn?Gly?Glu?Ala?Asp?Cys?Pro?Thr?Asp?Leu?Glu?Met?Ala?Ala?Pro?1???????????????5??????????????????10??????????????????15Arg?Gly?Gln?Asp?Arg?Trp?Ser?Gln?Glu?Asp?Met?Leu?Thr?Leu?Leu?Glu

20??????????????????25??????????????????30Cys?Met?Lys?Asn?Asn?Leu?Pro?Ser?Asn?Asp?Ser?Ser?Gln?Phe?Lys?Thr

35??????????????????40??????????????????45Thr?Gln?Thr?His?Met?Asp?Arg?Glu?Lys?Val?Ala?Leu?Lys?Asp?Phe?Ser

50??????????????????55??????????????????60Gly?Asp?Met?Cys?Lys?Leu?Lys?Trp?Val?Glu?Ile?Ser?Asn?Glu?Val?Arg65??????????????????70??????????????????75??????????????????80Lys?Phe?Arg?Thr?Leu?Thr?Glu?Leu?Ile?Leu?Asp?Thr?Gln?Glu?His?Val

85??????????????????90??????????????????95

<210>36

<211>129

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>36Gly?Ile?Val?Val?Phe?Ser?Leu?Gly?Ser?Met?Val?Ser?Glu?Ile?Pro?Glu?1???????????????5??????????????????10??????????????????15Lys?Lys?Ala?Val?Ala?Ile?Ala?Asp?Ala?Leu?Gly?Lys?Ile?Pro?Gln?Thr

20??????????????????25??????????????????30Val?Leu?Trp?Arg?Tyr?Thr?Gly?Thr?Arg?Pro?Ser?Asn?Leu?Ala?Asn?Asn

35??????????????????40??????????????????45Thr?Ile?Leu?Val?Gln?Trp?Leu?Pro?Gln?Asn?Asp?Leu?Leu?Gly?His?Pro

50??????????????????55??????????????????60Met?Thr?Arg?Ala?Phe?Ile?Thr?His?Ala?Ser?Ser?His?Gly?Val?Asn?Glu65??????????????????70??????????????????75??????????????????80Ser?Ile?Cys?Asn?Gly?Val?Pro?Met?Val?Met?Ile?Pro?Leu?Phe?Gly?Asp

85??????????????????90??????????????????95Gln?Met?Asp?Asn?Ala?Lys?Arg?Arg?Glu?Thr?Lys?Gly?Ala?Gly?Val?Thr

100?????????????????105?????????????????110Leu?Asn?Val?Leu?Glu?Met?Thr?Ser?Glu?Asp?Leu?Glu?Asp?Ala?Leu?Lys

115?????????????????120?????????????????125Ser

<210>37

<211>238

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>37Asn?Leu?Leu?Gly?Ile?Ser?Trp?Val?Asp?Ser?Ser?Trp?Ile?Pro?Ile?Leu?1???????????????5??????????????????10??????????????????15Asn?Ser?Gly?Ser?Val?Leu?Asp?Tyr?Phe?Ser?Glu?Arg?Ser?Asn?Pro?Phe

20??????????????????25??????????????????30Tyr?Asp?Arg?Thr?Cys?Asn?Asn?Glu?Val?Val?Lys?Met?Gln?Arg?Leu?Thr

35??????????????????40??????????????????45Leu?Glu?His?Leu?Asn?Gln?Met?Val?Gly?Ile?Glu?Tyr?Ile?Leu?Leu?His

50??????????????????55??????????????????60Ala?Gln?Glu?Pro?Ile?Leu?Phe?Ile?Ile?Arg?Lys?Gln?Gln?Arg?Gln?Ser65??????????????????70??????????????????75??????????????????80Pro?Ala?Gln?Val?Ile?Pro?Leu?Ala?Asp?Tyr?Tyr?Ile?Ile?Ala?Gly?Val

85??????????????????90??????????????????95Ile?Tyr?Gln?Ala?Pro?Asp?Leu?Gly?Ser?Val?Ile?Asn?Ser?Arg?Val?Leu

100?????????????????105?????????????????110Thr?Ala?Val?His?Gly?Ile?Gln?Ser?Ala?Phe?Asp?Glu?Ala?Met?Ser?Tyr

115?????????????????120?????????????????125Cys?Arg?Tyr?His?Pro?Ser?Lys?Gly?Tyr?Trp?Trp?His?Phe?Lys?Asp?His

130?????????????????135?????????????????140Glu?Glu?Gln?Asp?Lys?Val?Arg?Pro?Lys?Ala?Lys?Arg?Lys?Glu?Glu?Pro145?????????????????150?????????????????155?????????????????160Ser?Ser?Ile?Phe?Gln?Arg?Gln?Arg?Val?Asp?Ala?Leu?Leu?Leu?Asp?Leu

165?????????????????170?????????????????175Arg?Gln?Lys?Phe?Pro?Pro?Lys?Phe?Val?Gln?Leu?Lys?Pro?Gly?Glu?Lys

180?????????????????185?????????????????190Pro?Val?Pro?Val?Asp?Gln?Thr?Lys?Lys?Glu?Ala?Glu?Pro?Ile?Pro?Glu

195?????????????????200?????????????????205Thr?Val?Lys?Pro?Glu?Glu?Lys?Glu?Thr?Thr?Lys?Asn?Val?Gln?Gln?Thr

210?????????????????215?????????????????220Val?Ser?Ala?Lys?Gly?Pro?Pro?Glu?Lys?Arg?Met?Arg?Leu?Gln225?????????????????230?????????????????235

<210>38

<211>202

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>38Lys?Gly?Ser?Glu?Gly?Glu?Asn?Pro?Leu?Thr?Val?Pro?Gly?Arg?Glu?Lys?1???????????????5??????????????????10??????????????????15Glu?Gly?Met?Leu?Met?Gly?Val?Lys?Pro?Gly?Glu?Asp?Ala?Ser?Gly?Pro

20??????????????????25??????????????????30Ala?Glu?Asp?Leu?Val?Arg?Arg?Ser?Glu?Lys?Asp?Thr?Ala?Ala?Val?Val

35??????????????????40??????????????????45Ser?Arg?Gln?Gly?Ser?Ser?Leu?Asn?Leu?Phe?Glu?Asp?Val?Gln?Ile?Thr

50??????????????????55??????????????????60Glu?Pro?Glu?Ala?Glu?Pro?Glu?Ser?Lys?Ser?Glu?Pro?Arg?Pro?Pro?Ile65??????????????????70??????????????????75??????????????????80Ser?Ser?Pro?Arg?Ala?Pro?Gln?Thr?Arg?Ala?Val?Lys?Pro?Arg?Leu?His

85??????????????????90??????????????????95Pro?Val?Lys?Pro?Met?Asn?Ala?Thr?Ala?Thr?Lys?Val?Ala?Asn?Cys?Ser

100?????????????????105?????????????????110Leu?Gly?Thr?Ala?Thr?Ile?Ile?Gly?Glu?Asn?Leu?Asn?Asn?Glu?Val?Met

115?????????????????120?????????????????125Met?Lys?Lys?Tyr?Ser?Pro?Ser?Asp?Pro?Ala?Phe?Ala?Tyr?Ala?Gln?Leu

130?????????????????135?????????????????140Thr?His?Asp?Glu?Leu?Ile?Gln?Leu?Val?Leu?Lys?Gln?Lys?Glu?Thr?Ile145?????????????????150?????????????????155?????????????????160Ser?Lys?Lys?Glu?Phe?Gln?Val?Arg?Glu?Leu?Glu?Asp?Tyr?Ile?Asp?Asn

165?????????????????170?????????????????175Leu?Leu?Val?Arg?Val?Met?Glu?Glu?Thr?Pro?Asn?Ile?Leu?Arg?Ile?Pro

180?????????????????185?????????????????190Thr?Gln?Val?Gly?Lys?Lys?Ala?Gly?Lys?Met

195?????????????????200

<210>39

<211>243

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>39Val?Asn?Ala?Leu?Gly?Ile?Met?Ala?Ala?Val?Asp?Ile?Arg?Asp?Asn?Leu?1???????????????5??????????????????10??????????????????15Leu?Gly?Ile?Ser?Trp?Val?Asp?Ser?Ser?Trp?Ile?Pro?Ile?Leu?Asn?Ser

20??????????????????25??????????????????30Gly?Ser?Val?Leu?Asp?Tyr?Phe?Ser?Glu?Arg?Ser?Asn?Pro?Phe?Tyr?Asp

35??????????????????40??????????????????45Arg?Thr?Cys?Asn?Asn?Glu?Val?Val?Lys?Met?Gln?Arg?Leu?Thr?Leu?Glu

50??????????????????55??????????????????60His?Leu?Asn?Gln?Met?Val?Gly?Ile?Glu?Tyr?Ile?Leu?Leu?His?Ala?Gln65??????????????????70??????????????????75??????????????????80Glu?Pro?Ile?Leu?Phe?Ile?Ile?Arg?Lys?Gln?Gln?Arg?Gln?Ser?Pro?Ala

85??????????????????90??????????????????95Gln?Val?Ile?Pro?Leu?Ala?Asp?Tyr?Tyr?Ile?Ile?Ala?Gly?Val?Ile?Tyr

100?????????????????105?????????????????110Gln?Ala?pro?Asp?Leu?Gly?Ser?Val?Ile?Asn?Ser?Arg?Val?Leu?Thr?Ala

115?????????????????120?????????????????125Val?His?Gly?Ile?Gln?Ser?Ala?Phe?Asp?Glu?Ala?Met?Ser?Tyr?Cys?Arg

130?????????????????135?????????????????140Tyr?His?Pro?Ser?Lys?Gly?Tyr?Trp?Trp?His?Phe?Lys?Asp?His?Glu?Glu145?????????????????150?????????????????155?????????????????160Gln?Asp?Lys?Val?Arg?Pro?Lys?Ala?Lys?Arg?Lys?Glu?Glu?Pro?Ser?Ser

165?????????????????170?????????????????175Ile?Phe?Gln?Arg?Gln?Arg?Val?Asp?Ala?Leu?Leu?Leu?Asp?Leu?Arg?Gln

180?????????????????185?????????????????190Lys?Ile?Ser?Thr?Gln?Ile?Cys?Ala?Val?Asp?Gln?Thr?Lys?Lys?Glu?Ala

195?????????????????200?????????????????205Glu?Pro?Ile?Pro?Glu?Thr?Val?Lys?Pro?Glu?Glu?Lys?Glu?Thr?Thr?Lys

210?????????????????215?????????????????220Asn?Val?Gln?Gln?Thr?Val?Ser?Ala?Lys?Gly?Pro?Pro?Glu?Lys?Arg?Met225?????????????????230?????????????????235?????????????????240Arg?Leu?Gln

<210>40

<211>245

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>40Ala?Ala?Val?Asp?Ile?Arg?Asp?Asn?Leu?Leu?Gly?Ile?Ser?Trp?Val?Asp?1???????????????5??????????????????10??????????????????15Ser?Ser?Trp?Ile?Pro?Ile?Leu?Asn?Ser?Gly?Ser?Val?Leu?Asp?Tyr?Phe

20??????????????????25??????????????????30Ser?Glu?Arg?Ser?Asn?Pro?Phe?Tyr?Asp?Arg?Thr?Cys?Asn?Asn?Glu?Val

35??????????????????40??????????????????45Val?Lys?Met?Gln?Arg?Leu?Thr?Leu?Glu?His?Leu?Asn?Gln?Met?Val?Gly

50??????????????????55??????????????????60Ile?Glu?Tyr?Ile?Leu?Leu?His?Ala?Gln?Glu?Pro?Ile?Leu?Phe?Ile?Ile65??????????????????70??????????????????75??????????????????80Arg?Lys?Gln?Gln?Arg?Gln?Ser?Pro?Ala?Gln?Val?Ile?Pro?Leu?Ala?Asp

85??????????????????90??????????????????95Tyr?Tyr?Ile?Ile?Ala?Gly?Val?Ile?Tyr?Gln?Ala?Pro?Asp?Leu?Gly?Ser

100?????????????????105?????????????????110Val?Ile?Asn?Ser?Arg?Val?Leu?Thr?Ala?Val?His?Gly?Ile?Gln?Ser?Ala

115?????????????????120?????????????????125Phe?Asp?Glu?Ala?Met?Ser?Tyr?Cys?Arg?Tyr?His?Pro?Ser?Lys?Gly?Tyr

130?????????????????135?????????????????140Trp?Trp?His?Phe?Lys?Asp?His?Glu?Glu?Gln?Asp?Lys?Val?Arg?Pro?Lys145?????????????????150?????????????????155?????????????????160Ala?Lys?Arg?Lys?Glu?Glu?Pro?Ser?Ser?Ile?Phe?Gln?Arg?Gln?Arg?Val

165?????????????????170?????????????????175Asp?Ala?Leu?Leu?Leu?Asp?Leu?Arg?Gln?Lys?Phe?Pro?Pro?Lys?Phe?Val

180?????????????????185?????????????????190Gln?Leu?Lys?Pro?Gly?Glu?Lys?Pro?Val?Pro?Val?Asp?Gln?Thr?Lys?Lys

195?????????????????200?????????????????205Glu?Ala?Glu?Pro?Ile?Pro?Glu?Thr?Val?Lys?Pro?Glu?Glu?Lys?Glu?Thr

210?????????????????215?????????????????220Thr?Lys?Asn?Val?Gln?Gln?Thr?Val?Ser?Ala?Lys?Gly?Pro?Pro?Glu?Lys225?????????????????230?????????????????235?????????????????240Arg?Met?Arg?Leu?Gln

245

<210>41

<211>163

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>41Gly?Glu?Arg?Gln?Gly?Leu?Val?Ala?Arg?Ala?Arg?Leu?Ser?Leu?Arg?Pro?1???????????????5??????????????????10??????????????????15Ser?Ile?Pro?Glu?Leu?Ser?Glu?Arg?Thr?Ser?Arg?Pro?Cys?Arg?Ala?Ser

20??????????????????25??????????????????30Pro?Ala?Ser?Leu?Pro?Ser?Gln?His?Thr?Ser?Ser?Pro?Ala?Gln?Ala?Arg

35??????????????????40??????????????????45Val?Arg?Asn?Leu?Ala?Gln?Ser?Thr?Phe?Pro?Leu?Ala?Ala?Gln?Glu?Thr

50??????????????????55??????????????????60Pro?Gly?Arg?Ala?Pro?Ala?His?Ala?Pro?Leu?Ser?Ser?Phe?Val?Pro?Gly65??????????????????70??????????????????75??????????????????80Val?Gly?Gly?Arg?Ser?Pro?Ala?Ser?Val?Gly?Ile?Ser?Ala?Pro?Gly?Gly

85??????????????????90??????????????????95Gly?Pro?Ser?Gly?Ala?Ala?Ala?Lys?Ile?Pro?Leu?Glu?Leu?Thr?Gln?Ser

100?????????????????105?????????????????110Arg?Val?Gln?Lys?Ile?Trp?Val?Pro?Val?Asp?His?Arg?Pro?Ser?Leu?Pro

115?????????????????120?????????????????125Arg?Ser?Cys?Gly?Pro?Lys?Leu?Thr?Asn?Ser?Pro?Ala?Val?Phe?Val?Met

130?????????????????135?????????????????140Val?Gly?Leu?Pro?Arg?Pro?Gly?Gln?Asp?Leu?Leu?Leu?His?Glu?Ser?Leu145?????????????????150?????????????????155?????????????????160Leu?Ala?Ala

<210>42

<211>243

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>42Val?Asp?Ile?Arg?Asp?Asn?Leu?Leu?Gly?Ile?Ser?Trp?Val?Asp?Ser?Ser?1???????????????5??????????????????10??????????????????15Trp?Ile?Pro?Ile?Leu?Asn?Ser?Gly?Ser?Val?Leu?Asp?Tyr?Phe?Ser?Glu

20??????????????????25??????????????????30Arg?Ser?Asn?Pro?Phe?Tyr?Asp?Arg?Thr?Cys?Asn?Asn?Glu?Val?Val?Lys

35??????????????????40??????????????????45Met?Gln?Arg?Leu?Thr?Leu?Glu?His?Leu?Asn?Gln?Met?Val?Gly?Ile?Glu

50??????????????????55??????????????????60Tyr?Ile?Leu?Leu?His?Ala?Gln?Glu?Pro?Ile?Leu?Phe?Ile?Ile?Arg?Lys65??????????????????70??????????????????75??????????????????80Gln?Gln?Arg?Gln?Ser?Pro?Ala?Gln?Val?Ile?Pro?Leu?Ala?Asp?Tyr?Tyr

85??????????????????90??????????????????95Ile?Ile?Ala?Gly?Val?Ile?Tyr?Gln?Ala?Pro?Asp?Leu?Gly?Ser?Val?Ile

100?????????????????105?????????????????110Asn?Ser?Arg?Val?Leu?Thr?Ala?Val?His?Gly?Ile?Gln?Ser?Ala?Phe?Asp

115?????????????????120?????????????????125Glu?Ala?Met?Ser?Tyr?Cys?Arg?Tyr?His?Pro?Ser?Lys?Gly?Tyr?Trp?Trp

130?????????????????135?????????????????140His?Phe?Lys?Asp?His?Glu?Glu?Gln?Asp?Lys?Val?Arg?Pro?Lys?Ala?Lys145?????????????????150?????????????????155?????????????????160Arg?Lys?Glu?Glu?Pro?Ser?Ser?Ile?Phe?Gln?Arg?Gln?Arg?Val?Asp?Ala

165?????????????????170?????????????????175Leu?Leu?Leu?Asp?Leu?Arg?Gln?Lys?Phe?Pro?Pro?Lys?Phe?Val?Gln?Leu

180?????????????????185?????????????????190Lys?Pro?Gly?Glu?Lys?Pro?Val?Pro?Val?Asp?Gln?Thr?Lys?Lys?Glu?Ala

195?????????????????200?????????????????205Glu?Pro?Ile?Pro?Glu?Thr?Val?Lys?Pro?Glu?Glu?Lys?Glu?Thr?Thr?Lys

210?????????????????215?????????????????220Asn?Val?Gln?Gln?Thr?Val?Ser?Ala?Lys?Gly?Pro?Pro?Glu?Lys?Arg?Met225?????????????????230?????????????????235?????????????????240Arg?Leu?Gln

<210>43

<2ll>244

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>43Ala?Val?Asp?Ile?Arg?Asp?Asn?Leu?Leu?Gly?Ile?Ser?Trp?Val?Asp?Ser?1???????????????5??????????????????10??????????????????15Ser?Trp?Ile?Pro?Ile?Leu?Asn?Ser?Gly?Ser?Val?Leu?Asp?Tyr?Phe?Ser

20??????????????????25??????????????????30Glu?Arg?Ser?Asn?Pro?Phe?Tyr?Asp?Arg?Thr?Cys?Asn?Asn?Glu?Val?Val

35??????????????????40??????????????????45Lys?Met?Gln?Arg?Leu?Thr?Leu?Glu?His?Leu?Asn?Gln?Met?Val?Gly?Ile

50??????????????????55??????????????????60Glu?Tyr?Ile?Leu?Leu?His?Ala?Gln?Glu?Pro?Ile?Leu?Phe?Ile?Ile?Arg65??????????????????70??????????????????75??????????????????80Lys?Gln?Gln?Arg?Gln?Ser?Pro?Ala?Gln?Val?Ile?Pro?Leu?Ala?Asp?Tyr

85??????????????????90??????????????????95Tyr?Ile?Ile?Ala?Gly?Val?Ile?Tyr?Gln?Ala?Pro?Asp?Leu?Gly?Ser?Val

100?????????????????105?????????????????110Ile?Asn?Ser?Arg?Val?Leu?Thr?Ala?Val?His?Gly?Ile?Gln?Ser?Ala?Phe

115?????????????????120?????????????????125Asp?Glu?Ala?Met?Ser?Tyr?Cys?Arg?Tyr?His?Pro?Ser?Lys?Gly?Tyr?Trp

130?????????????????135?????????????????140Trp?His?Phe?Lys?Asp?His?Glu?Glu?Gln?Asp?Lys?Val?Arg?Pro?Lys?Ala145?????????????????150?????????????????155?????????????????160Lys?Arg?Lys?Glu?Glu?Pro?Ser?Ser?Ile?Phe?Gln?Arg?Gln?Arg?Val?Asp

165?????????????????170?????????????????175Ala?Leu?Leu?Leu?Asp?Leu?Arg?Gln?Lys?Phe?Pro?Pro?Lys?Phe?Val?Gln

180?????????????????185?????????????????190Leu?Lys?Pro?Gly?Glu?Lys?Pro?Val?Pro?Val?Asp?Gln?Thr?Lys?Lys?Glu

195?????????????????200?????????????????205Ala?Glu?Pro?Ile?Pro?Glu?Thr?Val?Lys?Pro?Glu?Glu?Lys?Glu?Thr?Thr

210?????????????????215?????????????????220Lys?Asn?Val?Gln?Gln?Thr?Val?Ser?Ala?Lys?Gly?Pro?Pro?Glu?Lys?Arg225?????????????????230?????????????????235?????????????????240Met?Arg?Leu?Gln

<210>44

<211>109

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>44Glu?Leu?His?Phe?Ser?Glu?Phe?Thr?Ser?Ala?Val?Ala?Asp?Met?Lys?Asn?1???????????????5??????????????????10??????????????????15Ser?Val?Ala?Asp?Arg?Asp?Asn?Ser?Pro?Ser?Ser?Cys?Ala?Gly?Leu?Phe

20??????????????????25??????????????????30Ile?Ala?Ser?His?Ile?Gly?Phe?Asp?Trp?Pro?Gly?Val?Trp?Val?His?Leu

35??????????????????40??????????????????45Asp?Ile?Ala?Ala?Pro?Val?His?Ala?Gly?Glu?Arg?Ala?Thr?Gly?Phe?Gly

50??????????????????55??????????????????60Val?Ala?Leu?Leu?Leu?Ala?Leu?Phe?Gly?Arg?Ala?Ser?Glu?Asp?Pro?Leu65??????????????????70??????????????????75??????????????????80Leu?Asn?Leu?Val?Ser?Pro?Leu?Asp?Cys?Glu?Val?Asp?Ala?Gln?Glu?Gly

85??????????????????90??????????????????95Asp?Asn?Met?Gly?Arg?Asp?Ser?Lys?Arg?Arg?Arg?Leu?Val

100?????????????????105

<210>45

<211>324

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>45Arg?Arg?Pro?Val?Met?Ala?Gln?Glu?Thr?Ala?Pro?Pro?Cys?Gly?Pro?Val?l???????????????5??????????????????10??????????????????15Ser?Arg?Gly?Asp?Ser?Pro?Ile?Ile?Glu?Lys?Met?Glu?Lys?Arg?Thr?Cys

20??????????????????25??????????????????30Ala?Leu?Cys?Pro?Glu?Gly?His?Glu?Trp?Ser?Gln?Ile?Tyr?Phe?Ser?Pro

35??????????????????40??????????????????45Ser?Gly?Asn?Ile?Val?Ala?His?Glu?Asn?Cys?Leu?Leu?Tyr?Ser?Ser?Gly

50??????????????????55??????????????????60Leu?Val?Glu?Cys?Glu?Thr?Leu?Asp?Leu?Arg?Asn?Thr?Ile?Arg?Asn?Phe65??????????????????70??????????????????75??????????????????80Asp?Val?Lys?Ser?Val?Lys?Lys?Glu?Ile?Trp?Arg?Gly?Arg?Arg?Leu?Lys

85??????????????????90??????????????????95Cys?Ser?Phe?Cys?Asn?Lys?Gly?Gly?Ala?Thr?Val?Gly?Cys?Asp?Leu?Trp

100?????????????????105?????????????????110Phe?Cys?Lys?Lys?Ser?Tyr?His?Tyr?Val?Cys?Ala?Lys?Lys?Asp?Gln?Ala

115?????????????????120?????????????????125Ile?Leu?Gln?Val?Asp?Gly?Asn?His?Gly?Thr?Tyr?Lys?Leu?Phe?Cys?Pro

130?????????????????135?????????????????140Glu?His?Ser?Pro?Glu?Gln?Glu?Glu?Ala?Thr?Glu?Ser?Ala?Asp?Asp?Pro145?????????????????150?????????????????155?????????????????160Ser?Met?Lys?Lys?Lys?Arg?Gly?Lys?Asn?Lys?Arg?Leu?Ser?Ser?Gly?Pro

165?????????????????170?????????????????175Pro?Ala?Gln?Pro?Lys?Thr?Met?Lys?Cys?Ser?Asn?Ala?Lys?Arg?His?Met

180?????????????????185?????????????????190Thr?Glu?Glu?Pro?His?Gly?His?Thr?Asp?Ala?Ala?Val?Lys?Ser?Pro?Phe

195?????????????????200?????????????????205Leu?Lys?Lys?Cys?Gln?Glu?Ala?Gly?Leu?Leu?Thr?Glu?Leu?Phe?Glu?His

210?????????????????215?????????????????220Ile?Leu?Glu?Asn?Met?Asp?Ser?Val?His?Gly?Arg?Leu?Val?Asp?Glu?Thr225?????????????????230?????????????????235?????????????????240Ala?Ser?Glu?Ser?Asp?Tyr?Glu?Gly?Ile?Glu?Thr?Leu?Leu?Phe?Asp?Cys

245?????????????????250?????????????????255Gly?Leu?Phe?Lys?Asp?Thr?Leu?Arg?Lys?Phe?Gln?Glu?Val?Ile?Lys?Ser

260?????????????????265?????????????????270Lys?Ala?Cys?Glu?Trp?Glu?Glu?Arg?Gln?Arg?Gln?Met?Lys?Gln?Gln?Leu

275?????????????????280?????????????????285Glu?Ala?Leu?Ala?Asp?Leu?Gln?Gln?Ser?Leu?Cys?Ser?Phe?Gln?Glu?Asn

290?????????????????295?????????????????300Gly?Asp?Leu?Asp?Cys?Ser?Ser?Ser?Thr?Ser?Gly?Ser?Leu?Leu?Pro?Pro305?????????????????310?????????????????315?????????????????320Glu?Asp?His?Gln

<210>46

<211>244

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>46Ala?Val?Asp?Ile?Arg?Asp?Asn?Leu?Leu?Gly?Ile?Ser?Trp?Val?Asp?Ser?1???????????????5??????????????????10??????????????????15Ser?Trp?Ile?Pro?Ile?Leu?Asn?Ser?Gly?Ser?Val?Leu?Asp?Tyr?Phe?Ser

20??????????????????25??????????????????30Glu?Arg?Ser?Asn?Pro?Phe?Tyr?Asp?Arg?Thr?Cys?Asn?Asn?Glu?Val?Val

35??????????????????40??????????????????45Lys?Met?Gln?Arg?Leu?Thr?Leu?Glu?His?Leu?Asn?Gln?Met?Val?Gly?Ile

50??????????????????55??????????????????60Glu?Tyr?Ile?Leu?Leu?His?Ala?Gln?Glu?Pro?Ile?Leu?Phe?Ile?Ile?Arg65??????????????????70??????????????????75??????????????????80Lys?Gln?Gln?Arg?Gln?Ser?Pro?Ala?Gln?Val?Ile?Pro?Leu?Ala?Asp?Tyr

85??????????????????90??????????????????95Tyr?Ile?Ile?Ala?Gly?Val?Ile?Tyr?Gln?Ala?Pro?Asp?Leu?Gly?Ser?Val

100?????????????????105?????????????????110Ile?Asn?Ser?Arg?Val?Leu?Thr?Ala?Val?His?Gly?Ile?Gln?Ser?Ala?Phe

115?????????????????120?????????????????125Asp?Glu?Ala?Met?Ser?Tyr?Cys?Arg?Tyr?His?Pro?Ser?Lys?Gly?Tyr?Trp

130?????????????????135?????????????????140Trp?His?Phe?Lys?Asp?His?Glu?Glu?Gln?Asp?Lys?Val?Arg?Pro?Lys?Ala145?????????????????150?????????????????155?????????????????160Lys?Arg?Lys?Glu?Glu?Pro?Ser?Ser?Ile?Phe?Gln?Arg?Gln?Arg?Val?Asp

165?????????????????170?????????????????175Ala?Leu?Leu?Leu?Asp?Leu?Arg?Gln?Lys?Phe?Pro?Pro?Lys?Phe?Val?Gln

180?????????????????185?????????????????190Leu?Lys?Pro?Gly?Glu?Lys?Pro?Val?Pro?Val?Asp?Gln?Thr?Lys?Lys?Glu

195?????????????????200?????????????????205Ala?Glu?Pro?Ile?Pro?Glu?Thr?Val?Lys?Pro?Glu?Glu?Lys?Glu?Thr?Thr

210?????????????????215?????????????????220Lys?Asn?Val?Gln?Gln?Thr?Val?Ser?Ala?Lys?Gly?Pro?Pro?Glu?Lys?Arg225?????????????????230?????????????????235?????????????????240Met?Arg?Leu?Gln

<210>47

<211>14

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>47tttttttttt?ttag?????????????????????????????????????????????????????14

<210>48

<211>10

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>48cttcaacctc???????????????????????????????????????????????????????????10

<210>49

<211>496

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>49gcaccatgta?ccgagcactt?cggctcctcg?cgcgctcgcg?tcccctcgtg?cgggctccag?????60ccgcagcctt?agcttcggct?cccggcttgg?gtggcgcggc?cgtgccctcg?ttttggcctc????120cgaacgcggc?tcgaatggca?agccaaaatt?ccttccggat?agaatatgat?acctttggtg????180aactaaaggt?gccaaatgat?aagtattatg?gcgcccagac?cgtgagatct?acgatgaact????240ttaagattgg?aggtgtgaca?gaacgcatgc?caaccccagt?tattaaagct?tttggcatct????300tgaagcgagc?ggccgctgaa?gtaaaccagg?attatggtct?tgatccaaag?attgctaatg????360caataatgaa?ggcagcagat?gaggtagctg?aaggtaaatt?aaatgatcat?tttcctctcg????420tggtatggca?gactggatca?ggaactcaga?caaatatgaa?tgtaaatgaa?gtcattagcc????480aatagagcaa?ttgaaa????????????????????????????????????????????????????496

<210>50

<211>499

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>50agaaaaagtc?tatgtttgca?gaaatacaga?tccaagacaa?agacaggatg?ggcactgctg?????60gaaaagttat?taaatgcaaa?gcagctgtgc?tttgggagca?gaagcaaccc?ttctccattg????120aggaaataga?agttgcccca?ccaaagacta?aagaagttcg?cattaagatt?ttggccacag????180gaatctgtcg?cacagatgac?catgtgataa?aaggaacaat?ggtgtccaag?tttccagtga????240ttgtgggaca?tgaggcaact?gggattgtag?agagcattgg?agaaggagtg?actacagtga????300aaccaggtga?caaagtcatc?cctctctttc?tgccacaatg?tagagaatgc?aatgcttgtc????360gcaacccaga?tggcaacctt?tgcattagga?gcgatattac?tggtcgtgga?gtactggctg????420atggcaccac?cagatttaca?tgcaagggcg?aaccagtcca?ccacttcatg?aacaccagta????480catttaccga?gtacacagt?????????????????????????????????????????????????499

<210>51

<211>887

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>51gagtctgagc?agaaaggaaa?agcagccttg?gcagccacgt?tagaggaata?caaagccaca?????60gtggccagtg?accagataga?gatgaatcgc?ctgaaggctc?agctggagaa?tgaaaagcag????120aaagtggcag?agctgtattc?tatccataac?tctggagaca?aatctgatat?tcaggacctc????180ctggagagtg?tcaggctgga?caaagaaaaa?gcagagactt?tggctagtag?cttgcaggaa????240gatctggctc?atacccgaaa?tgatgccaat?cgattacagg?atgccattgc?taaggtagag????300gatgaatacc?gagccttcca?agaagaagct?aagaaacaaa?ttgaagattt?gaatatgacg????360ttagaaaaat?taagatcaga?cctggatgaa?aaagaaacag?aaaggagtga?catgaaagaa????420accatctttg?aacttgaaga?tgaagtagaa?caacatcgtg?ctgtgaaact?tcatgacaac????480ctcattattt?ctgatctaga?gaatacagtt?aaaaaactcc?aggaccaaaa?gcacgacatg????540gaaagagaaa?taaagacact?ccacagaaga?cttcgggaag?aatctgcgga?atggcggcag????600tttcaggctg?atctccagac?tgcagtagtc?attgcaaatg?acattaaatc?tgaagcccaa????660gaggagattg?gtgatctaaa?gcgccggtta?catgaggctc?aagaaaaaaa?tgagaaactc????720acaaaagaat?tggaggaaat?aaagtcacgc?aagcaagagg?aggagcgagg?cgggtataca????780attacatgaa?tgccgttgag?agagatttgg?cagccttaag?gcagggaatg?ggactgagta????840gaaggtcctc?gacttcctca?gagccaactc?ctacagtaaa?aaccctc??????????????????887

<210>52

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>52ggcacgagct?tttccaaaaa?tcatgctgct?cctttctcta?aagttcttac?attttataga?????60aaggaacctt?tcactcttga?ggcctactac?agctctcctc?aggatttgcc?ctatccagat????120cctgctatag?ctcagttttc?agttcagaaa?gtcactcctc?agtctgatgg?ctccagttca????180aaagtgaaag?tcaaagttcg?agtaaatgtc?catggcattt?tcagtgtgtc?cagtgcatct????240ttagtggagg?ttcacaagtc?tgaggaaaat?gaggagccaa?tggaaacaga?tcagaatgca????300aaggaggaag?agaagatgca?agtggaccag?gaggaaccac?atgttgaaga?gcaacagcag????360cagacaccag?gcagaaaata?aggcagagtc?tgaagaaatg?gagacctctc?aagctggatc????420caaggataaa?aagatggacc?aaccacccca?agccaagaag?gcaaaagtga?agaccagtac????480tgtggacctg?g?????????????????????????????????????????????????????????491

<210>53

<211>787

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>53aagcagttga?gtaggcagaa?aaaagaacct?cttcattaag?gattaaaatg?tataggccag?????60cacgtgtaac?ttcgacttca?agatttctga?atccatatgt?agtatgtttc?attgtcgtcg????120caggggtagt?gatcctggca?gtcaccatag?ctctacttgt?ttacttttta?gcttttgatc????180aaaaatctta?cttttatagg?agcagttttc?aactcctaaa?tgttgaatat?aatagtcagt????240taaattcacc?agctacacag?gaatacagga?ctttgagtgg?aagaattgaa?tctctgatta????300ctaaaacatt?caaagaatca?aatttaagaa?atcagttcat?cagagctcat?gttgccaaac????360tgaggcaaga?tggtagtggt?gtgagagcgg?atgttgtcat?gaaatttcaa?ttcactagaa????420ataacaatgg?agcatcaatg?aaaagcagaa?ttgagtctgt?tttacgacaa?atgctgaata????480actctggaaa?cctggaaata?aacccttcaa?ctgagataac?atcacttact?gaccaggctg????540cagcaaattg?gcttattaat?gaatgtgggg?ccggtccaga?cctaataaca?ttgtctgagc????600agagaatcct?tggaggcact?gaggctgagg?agggaagctg?gccgtggcaa?gtcagtctgc????660ggctcaataa?tgcccaccac?tgtggaggca?gcctgatcaa?taacatgtgg?atcctgacag????720cagctcactg?cttcagaagc?aactctaatc?ctcgtgactg?gattgccacg?tctggtattt????780ccacaac??????????????????????????????????????????????????????????????787

<210>54

<211>386

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>54ggcattttca?gtgtgtccag?tgcatcttta?gtggaggttc?acaagtctga?ggaaaatgag?????60gagccaatgg?aaacagatca?gaatgcaaag?gaggaagaga?agatgcaagt?ggaccaggag????120gaaccacatg?ttgaagagca?acagcagcag?acaccagcag?aaaataaggc?agagtctgaa????180gaaatggaga?cctctcaagc?tggatccaag?gataaaaaga?tggaccaacc?accccaagcc????240aagaaggcaa?aagtgaagac?cagtactgtg?gacctgccaa?tcgagaatca?gctattatgg????300cagatagaca?gagagatgct?caacttgtac?attgaaaatg?agggtaagat?gatcatgcag????360gataaactgg?agaaggagcg?gaatga?????????????????????????????????????????386

<210>55

<211>1462

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>55aagcagttga?gtaggcagaa?aaaagaacct?cttcattaag?gattaaaatg?tataggccag??????60cacgtgtaac?ttcgacttca?agatttctga?atccatatgt?agtatgtttc?attgtcgtcg?????120caggggtagt?gatcctggca?gtcaccatag?ctctacttgt?ttacttttta?gcttttgatc?????180aaaaatctta?cttttatagg?agcagttttc?aactcctaaa?tgttgaatat?aatagtcagt?????240taaattcacc?agctacacag?gaatacagga?ctttgagtgg?aagaattgaa?tctctgatta?????300ctaaaacatt?caaagaatca?aatttaagaa?atcagttcat?cagagctcat?gttgccaaac?????360tgagggaaga?tggtagtggt?gtgagagcgg?atgttgtcat?gaaatttcaa?ttcactagaa?????420ataacaatgg?agcatcaatg?aaaagcagaa?ttgagtctgt?tttacgacaa?atgctgaata?????480actctggaaa?cctggaaata?aacccttcaa?ctgagataac?atcacttact?gaccaggctg?????540cagcaaattg?gcttattaat?gaatgtgggg?ccggtccaga?cctaataaca?ttgtctgagc?????600agagaatcct?tggaggcact?gaggctgagg?agggaagctg?gccgtggcaa?gtcagtctgc?????660ggctcaataa?tgcccaccac?tgtggaggca?gcctgatcaa?taacatgtgg?atcctgacag?????720cagctcactg?cttcagaagc?aactctaatc?ctcgtgactg?gattgccacg?tctggtattt?????780ccacaacatt?tcctaaacta?agaatgagag?taagaaatat?tttaattcat?aacaattata?????840aatctgcaac?tcatgaaaat?gacattgcac?ttgtgagact?tgagaacagt?gtcaccttta?????900ccaaagatat?ccatagtgtg?tgtctcccag?ctgctaccca?gaatattcca?cctggctcta?????960ctgcttatgt?aacaggatgg?ggcgctcaag?aatatgctgg?ccacacagtt?ccagagctaa????1020ggcaaggaca?ggtcagaata?ataagtaatg?atgtatgtaa?tgcaccacat?agttataatg????1080gagccatctt?gtctggaatg?ctgtgtgctg?gagtacctca?aggtggagtg?gacgcatgtc????1140agggtgactc?tggtggccca?ctagtacaag?aagactcacg?gcggctttgg?tttattgtgg????1200ggatagtaag?ctggggagat?cagtgtggcc?tgccggataa?gccaggagtg?tatactcgag????1260tgacagcata?cattgactgg?attaggcaac?aaactgggat?ctagtgcaac?aagtgcatcc????1320ctgttgcaaa?gtctgtatgc?aggtgtgcct?gtcttaaatt?ccaaagcttt?acatttcaac????1380tgaaaaagaa?actagaaatg?tcctaattta?acatcttgtt?acataaatat?ggtttaacaa????1440aaaaaaaaaa?aaaaaactcg?ag?????????????????????????????????????????????1462

<210>56

<211>159

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>56Thr?Met?Tyr?Arg?Ala?Leu?Arg?Leu?Leu?Ala?Arg?Ser?Arg?Pro?Leu?Val?1???????????????5??????????????????10??????????????????15Arg?Ala?Pro?Ala?Ala?Ala?Leu?Ala?Ser?Ala?Pro?Gly?Leu?Gly?Gly?Ala

20??????????????????25??????????????????30Ala?Val?Pro?Ser?Phe?Trp?Pro?Pro?Asn?Ala?Ala?Arg?Met?Ala?Ser?Gln

35??????????????????40??????????????????45Asn?Ser?Phe?Arg?Ile?Glu?Tyr?Asp?Thr?Phe?Gly?Glu?Leu?Lys?Val?Pro

50??????????????????55??????????????????60Asn?Asp?Lys?Tyr?Tyr?Gly?Ala?Gln?Thr?Val?Arg?Ser?Thr?Met?Asn?Phe65??????????????????70??????????????????75??????????????????80Lys?Ile?Gly?Gly?Val?Thr?Glu?Arg?Met?Pro?Thr?Pro?Val?Ile?Lys?Ala

85??????????????????90??????????????????95Phe?Gly?Ile?Leu?Lys?Arg?Ala?Ala?Ala?Glu?Val?Asn?Gln?Asp?Tyr?Gly

100?????????????????105?????????????????110Leu?Asp?Pro?Lys?Ile?Ala?Asn?Ala?Ile?Met?Lys?Ala?Ala?Asp?Glu?Val

115?????????????????120?????????????????125Ala?Glu?Gly?Lys?Leu?Asn?Asp?His?Phe?Pro?Leu?Val?Val?Trp?Gln?Thr

130?????????????????135?????????????????140Gly?Ser?Gly?Thr?Gln?Thr?Asn?Met?Asn?Val?Asn?Glu?Val?Ile?Ser145?????????????????150?????????????????155

<210>57

<211>165

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>57Lys?Lys?Ser?Met?Phe?Ala?Glu?Ile?Gln?Ile?Gln?Asp?Lys?Asp?Arg?Met?1???????????????5??????????????????10??????????????????15Gly?Thr?Ala?Gly?Lys?Val?Ile?Lys?Cys?Lys?Ala?Ala?Val?Leu?Trp?Glu

20??????????????????25??????????????????30Gln?Lys?Gln?Pro?Phe?Ser?Ile?Glu?Glu?Ile?Glu?Val?Ala?Pro?Pro?Lys

35??????????????????40??????????????????45Thr?Lys?Glu?Val?Arg?Ile?Lys?Ile?Leu?Ala?Thr?Gly?Ile?Cys?Arg?Thr

50??????????????????55??????????????????60Asp?Asp?His?Val?Ile?Lys?Gly?Thr?Met?Val?Ser?Lys?Phe?Pro?Val?Ile65??????????????????70??????????????????75??????????????????80Val?Gly?His?Glu?Ala?Thr?Gly?Ile?Val?Glu?Ser?Ile?Gly?Glu?Gly?Val

85??????????????????90??????????????????95Thr?Thr?Val?Lys?Pro?G1y?Asp?Lys?Val?Ile?Pro?Leu?Phe?Leu?Pro?Gln

100?????????????????105?????????????????110Cys?Arg?Glu?Cys?Asn?Ala?Cys?Arg?Asn?Pro?Asp?Gly?Asn?Leu?Cys?Ile

115?????????????????120?????????????????125Arg?Ser?Asp?Ile?Thr?Gly?Arg?Gly?Val?Leu?Ala?Asp?Gly?Thr?Thr?Arg

130?????????????????135?????????????????140Phe?Thr?Cys?Lys?Gly?Glu?Pro?Val?His?His?Phe?Met?Asn?Thr?Ser?Thr145?????????????????150?????????????????155?????????????????160Phe?Thr?Glu?Tyr?Thr

165

<210>58

<211>259

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>58Glu?Ser?Glu?Gln?Lys?Gly?Lys?Ala?Ala?Leu?Ala?Ala?Thr?Leu?Glu?Glu?1???????????????5??????????????????10??????????????????15Tyr?Lys?Ala?Thr?Val?Ala?Ser?Asp?Gln?Ile?Glu?Met?Asn?Arg?Leu?Lys

20??????????????????25??????????????????30Ala?Gln?Leu?Glu?Asn?Glu?Lys?Gln?Lys?Val?Ala?Glu?Leu?Tyr?Ser?Ile

35??????????????????40??????????????????45His?Asn?Ser?Gly?Asp?Lys?Ser?Asp?Ile?Gln?Asp?Leu?Leu?Glu?Ser?Val

50??????????????????55??????????????????60Arg?Leu?Asp?Lys?Glu?Lys?Ala?Glu?Thr?Leu?Ala?Ser?Ser?Leu?Gln?Glu65??????????????????70??????????????????75??????????????????80Asp?Leu?Ala?His?Thr?Arg?Asn?Asp?Ala?Asn?Arg?Leu?Gln?Asp?Ala?Ile

85??????????????????90??????????????????95Ala?Lys?Val?Glu?Asp?Glu?Tyr?Arg?Ala?Phe?Gln?Glu?Glu?Ala?Lys?Lys

100?????????????????105?????????????????110Gln?Ile?Glu?Asp?Leu?Asn?Met?Thr?Leu?Glu?Lys?Leu?Arg?Ser?Asp?Leu

115?????????????????120?????????????????125Asp?Glu?Lys?Glu?Thr?Glu?Arg?Ser?Asp?Met?Lys?Glu?Thr?Ile?Phe?Glu

130?????????????????135?????????????????140Leu?Glu?Asp?Glu?Val?Glu?Gln?His?Arg?Ala?Val?Lys?Leu?His?Asp?Asn145?????????????????150?????????????????155?????????????????160Leu?Ile?Ile?Ser?Asp?Leu?Glu?Asn?Thr?Val?Lys?Lys?Leu?Gln?Asp?Gln

165?????????????????170?????????????????175Lys?His?Asp?Met?Glu?Arg?Glu?Ile?Lys?Thr?Leu?His?Arg?Arg?Leu?Arg

180?????????????????185?????????????????190Glu?Glu?Ser?Ala?Glu?Trp?Arg?Gln?Phe?Gln?Ala?Asp?Leu?Gln?Thr?Ala

195?????????????????200?????????????????205Val?Val?Ile?Ala?Asn?Asp?Ile?Lys?Ser?Glu?Ala?Gln?Glu?Glu?Ile?Gly

210?????????????????215?????????????????220Asp?Leu?Lys?Arg?Arg?Leu?His?Glu?Ala?Gln?Glu?Lys?Asn?Glu?Lys?Leu225?????????????????230?????????????????235?????????????????240Thr?Lys?Glu?Leu?Glu?Glu?Ile?Lys?Ser?Arg?Lys?Gln?Glu?Glu?Glu?Arg

245?????????????????250?????????????????255Gly?Gly?Tyr

<210>59

<211>125

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>59Gly?Thr?Ser?Phe?Ser?Lys?Asn?His?Ala?Ala?Pro?Phe?Ser?Lys?Val?Leu?1???????????????5??????????????????10??????????????????15Thr?Phe?Tyr?Arg?Lys?Glu?Pro?Phe?Thr?Leu?Glu?Ala?Tyr?Tyr?Ser?Ser

20??????????????????25??????????????????30Pro?Gln?Asp?Leu?Pro?Tyr?Pro?Asp?Pro?Ala?Ile?Ala?Gln?Phe?Ser?Val

35??????????????????40??????????????????45Gln?Lys?Val?Thr?Pro?Gln?Ser?Asp?Gly?Ser?Ser?Ser?Lys?Val?Lys?Val

50??????????????????55??????????????????60Lys?Val?Arg?Val?Asn?Val?His?Gly?Ile?Phe?Ser?Val?Ser?Ser?Ala?Ser65??????????????????70??????????????????75??????????????????80Leu?Val?Glu?Val?His?Lys?Ser?Glu?Glu?Asn?Glu?Glu?Pro?Met?Glu?Thr

85??????????????????90??????????????????95Asp?Gln?Asn?Ala?Lys?Glu?Glu?Glu?Lys?Met?Gln?Val?Asp?Gln?Glu?Glu

100?????????????????105?????????????????110Pro?His?Val?Glu?Glu?Gln?Gln?Gln?Gln?Thr?Pro?Gly?Arg

115?????????????????120?????????????????125

<210>60

<211>246

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>60Met?Tyr?Arg?Pro?Ala?Arg?Val?Thr?Ser?Thr?Ser?Arg?Phe?Leu?Asn?Pro?1???????????????5??????????????????10??????????????????15Tyr?Val?Val?Cys?Phe?Ile?Val?Val?Ala?Gly?Val?Val?Ile?Leu?Ala?Val

20??????????????????25??????????????????30Thr?Ile?Ala?Leu?Leu?Val?Tyr?Phe?Leu?Ala?Phe?Asp?Gln?Lys?Ser?Tyr

35??????????????????40??????????????????45Phe?Tyr?Arg?Ser?Ser?Phe?Gln?Leu?Leu?Asn?Val?Glu?Tyr?Asn?Ser?Gln

50??????????????????55??????????????????60Leu?Asn?Ser?Pro?Ala?Thr?Gln?Glu?Tyr?Arg?Thr?Leu?Ser?Gly?Arg?Ile65??????????????????70??????????????????75??????????????????80Glu?Ser?Leu?Ile?Thr?Lys?Thr?Phe?Lys?Glu?Ser?Asn?Leu?Arg?Asn?Gln

85??????????????????90??????????????????95Phe?Ile?Arg?Ala?His?Val?Ala?Lys?Leu?Arg?Gln?Asp?Gly?Ser?Gly?Val

100?????????????????105?????????????????110Arg?Ala?Asp?Val?Val?Met?Lys?Phe?Gln?Phe?Thr?Arg?Asn?Asn?Asn?Gly

115?????????????????120?????????????????125Ala?Ser?Met?Lys?Ser?Arg?Ile?Glu?Ser?Val?Leu?Arg?Gln?Met?Leu?Asn

130?????????????????135?????????????????140Asn?Ser?Gly?Asn?Leu?Glu?Ile?Asn?Pro?Ser?Thr?Glu?Ile?Thr?Ser?Leu145?????????????????150?????????????????155?????????????????160Thr?Asp?Gln?Ala?Ala?Ala?Asn?Trp?Leu?Ile?Asn?Glu?Cys?Gly?Ala?Gly

165?????????????????170?????????????????175Pro?Asp?Leu?Ile?Thr?Leu?Ser?Glu?Gln?Arg?Ile?Leu?Gly?Gly?Thr?Glu

180?????????????????185?????????????????190Ala?Glu?Glu?Gly?Ser?Trp?Pro?Trp?Gln?Val?Ser?Leu?Arg?Leu?Asn?Asn

195?????????????????200?????????????????205Ala?His?His?Cys?Gly?Gly?Ser?Leu?Ile?Asn?Asn?Met?Trp?Ile?Leu?Thr

210?????????????????215?????????????????220Ala?Ala?His?Cys?Phe?Arg?Ser?Asn?Ser?Asn?Pro?Arg?Asp?Trp?Ile?Ala225?????????????????230?????????????????235?????????????????240Thr?Ser?Gly?Ile?Ser?Thr

245

<210>61

<211>128

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>6lGly?Ile?Phe?Ser?Val?Ser?Ser?Ala?Ser?Leu?Val?Glu?Val?His?Lys?Ser?1???????????????5??????????????????10??????????????????15Glu?Glu?Asn?Glu?Glu?Pro?Met?Glu?Thr?Asp?Gln?Asn?Ala?Lys?Glu?Glu

20??????????????????25??????????????????30Glu?Lys?Met?Gln?Val?Asp?Gln?Glu?Glu?Pro?His?Val?Glu?Glu?Gln?Gln

35??????????????????40??????????????????45Gln?Gln?Thr?Pro?Ala?Glu?Asn?LVs?Ala?Glu?Ser?Glu?Glu?Met?Glu?Thr

50??????????????????55??????????????????60Ser?Gln?Ala?Gly?Ser?Lys?Asp?Lys?Lys?Met?Asp?Gln?Pro?Pro?Gln?Ala65??????????????????70??????????????????75??????????????????80Lys?Lys?Ala?Lys?Val?Lys?Thr?Ser?Thr?Val?Asp?Leu?Pro?Ile?Glu?Asn

85??????????????????90??????????????????95Gln?Leu?Leu?Trp?Gln?Ile?Asp?Arg?Glu?Met?Leu?Asn?Leu?Tyr?Ile?Glu

100?????????????????105?????????????????110Asn?Glu?Gly?Lys?Met?Ile?Met?Gln?Asp?Lys?Leu?Glu?Lys?Glu?Arg?Asn

115?????????????????120?????????????????125

<210>62

<211>418

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>62Met?Tyr?Arg?Pro?Ala?Arg?Val?Thr?Ser?Thr?Ser?Arg?Phe?Leu?Asn?Pro?1???????????????5??????????????????10??????????????????15Tyr?Val?Val?Cys?Phe?Ile?Val?Val?Ala?Gly?Val?Val?Ile?Leu?Ala?Val

20??????????????????25??????????????????30Thr?Ile?Ala?Leu?Leu?Val?Tyr?Phe?Leu?Ala?Phe?Asp?Gln?Lys?Ser?Tyr

35??????????????????40??????????????????45Phe?Tyr?Arg?Ser?Ser?Phe?Gln?Leu?Leu?Asn?Val?Glu?Tyr?Asn?Ser?Gln

50??????????????????55??????????????????60Leu?Asn?Ser?Pro?Ala?Thr?Gln?Glu?Tyr?Arg?Thr?Leu?Ser?Gly?Arg?Ile65??????????????????70??????????????????75??????????????????80Glu?Ser?Leu?Ile?Thr?Lys?Thr?Phe?Lys?Glu?Ser?Asn?Leu?Arg?Asn?Gln

85??????????????????90??????????????????95Phe?Ile?Arg?Ala?His?Val?Ala?Lys?Leu?Arg?Gln?Asp?Gly?Ser?Gly?Val

100?????????????????105?????????????????110Arg?Ala?Asp?Val?Val?Met?Lys?Phe?Gln?phe?Thr?Arg?Asn?Asn?Asn?Gly

115?????????????????120?????????????????125Ala?Ser?Met?Lys?Ser?Arg?Ile?Glu?Ser?Val?Leu?Arg?Gln?Met?Leu?Asn

130?????????????????135?????????????????140Asn?Ser?Gly?Asn?Leu?Glu?Ile?Asn?Pro?Ser?Thr?Glu?Ile?Thr?Ser?Leu145?????????????????150?????????????????155?????????????????160Thr?Asp?Gln?Ala?Ala?Ala?Asn?Trp?Leu?Ile?Asn?Glu?Cys?Gly?Ala?Gly

165?????????????????170?????????????????175Pro?Asp?Leu?Ile?Thr?Leu?Ser?Glu?Gln?Arg?Ile?Leu?Gly?Gly?Thr?Glu

180?????????????????185?????????????????190Ala?Glu?Glu?Gly?Ser?Trp?Pro?Trp?Gln?Val?Ser?Leu?Arg?Leu?Asn?Asn

195?????????????????200?????????????????205Ala?His?His?Cys?Gly?Gly?Ser?Leu?Ile?Asn?Asn?Met?Trp?Ile?Leu?Thr

210?????????????????215?????????????????220Ala?Ala?His?Cys?Phe?Arg?Ser?Asn?Ser?Asn?Pro?Arg?Asp?Trp?Ile?Ala225?????????????????230?????????????????235?????????????????240Thr?Ser?Gly?Ile?Ser?Thr?Thr?Phe?Pro?Lys?Leu?Arg?Met?Arg?Val?Arg

245?????????????????250?????????????????255Asn?Ile?Leu?Ile?His?Asn?Asn?Tyr?Lys?Ser?Ala?Thr?His?Glu?Asn?Asp

260?????????????????265?????????????????270Ile?Ala?Leu?Val?Arg?Leu?Glu?Asn?Ser?Val?Thr?Phe?Thr?Lys?Asp?Ile

275?????????????????280?????????????????285His?Ser?Val?Cys?Leu?Pro?Ala?Ala?Thr?Gln?Asn?Ile?Pro?Pro?Gly?Ser

290?????????????????295?????????????????300Thr?Ala?Tyr?Val?Thr?Gly?Trp?Gly?Ala?Gln?Glu?Tyr?Ala?Gly?His?Thr305?????????????????310?????????????????315?????????????????320Val?Pro?Glu?Leu?Arg?Gln?Gly?Gln?Val?Arg?Ile?Ile?Ser?Asn?Asp?Val

325?????????????????330?????????????????335Cys?Asn?Ala?Pro?His?Ser?Tyr?Asn?Gly?Ala?Ile?Leu?Ser?Gly?Met?Leu

340?????????????????345?????????????????350Cys?Ala?Gly?Val?Pro?Gln?Gly?Gly?Val?Asp?Ala?Cys?Gln?Gly?Asp?Ser

355?????????????????360?????????????????365Gly?Gly?Pro?Leu?Val?Gln?Glu?Asp?Ser?Arg?Arg?Leu?Trp?Phe?Ile?Val

370?????????????????375?????????????????380Gly?Ile?Val?Ser?Trp?Gly?Asp?Gln?Cys?Gly?Leu?Pro?Asp?Lys?Pro?Gly385?????????????????390?????????????????395?????????????????400Val?Tyr?Thr?Arg?Val?Thr?Ala?Tyr?Ile?Asp?Trp?Ile?Arg?Gln?Gln?Thr

405?????????????????410?????????????????415Gly?Ile

<210>63

<211>776

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>63cacagatggt?gatagaggaa?tccatcttgc?agtcagataa?agccctcact?gatagagaga?????60aggcagtagc?agtggatcgg?gccaagaagg?aggcagctga?gaaggaacag?gaacttttaa????120aacagaaatt?acaggagcag?ccagcaacag?atggaggctc?aagataagag?tcgcaaggaa????180aactagccaa?ctgaaggaga?agctgcagat?ggagagagaa?cacctactga?gagagcagat????240tatgatgttg?gagcacacgc?agaaggtcca?aaatgattgg?cttcatgaag?gatttaagaa????300gaagtatgag?gagatgaatg?cagagataag?tcaatttaaa?cgtatgattg?atactacaaa????360aaatgatgat?actccctgga?ttgcacgaac?cttggacaac?cttgccgatg?agctaactgc????420aatattgtct?gctcctgcta?aattaattgg?tcatggtgtc?aaaggtgtga?gctcactctt????480taaaaagcat?aagctcccct?tttaaggata?ttatagattg?tacatatatg?ctttggacta????540tttttgatct?gtatgttttt?cattttcatt?cagcaagttt?tttttttttt?tcagagtctt????600actctgttgc?ccaggctgga?gtacagtggt?gcaatctcag?ctcactgcaa?cctctgcctc????660ctgggttcaa?gagattcacc?tgcctcagcc?ccctagtagc?tgggattata?ggtgtacacc????720accacaccca?gctaattttt?gtatttttag?tagagatggg?gtttcactat?gttggc????????776

<210>64

<211>160

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>64gcagcgctct?cggttgcagt?acccactgga?aggacttagg?cgctcgcgtg?gacaccgcaa?????60gcccctcagt?agcctcggcc?caagaggcct?gctttccact?cgctagcccc?gccgggggtc????120cgtgtcctgt?ctcggtggcc?ggacccgggc?ccgagcccga??????????????????????????160

<210>65

<211>72

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>65Leu?Ser?Ala?Met?Gly?Phe?Thr?Ala?Ala?Gly?Ile?Ala?Ser?Ser?Ser?Ile?l???????????????5??????????????????10??????????????????15Ala?Ala?Lys?Met?Met?Ser?Ala?Ala?Ala?Ile?Ala?Asn?Gly?Gly?Gly?Val

20??????????????????25??????????????????30Ala?Ser?Gly?Ser?Leu?Val?Ala?Thr?Leu?Gln?Ser?Leu?Gly?Ala?Thr?Gly

35??????????????????40??????????????????45Leu?Ser?Gly?Leu?Thr?Lys?Phe?Ile?Leu?Gly?Ser?Ile?Gly?Ser?Ala?Ile

50??????????????????55??????????????????60Ala?Ala?Val?Ile?Ala?Arg?Phe?Tyr65??????????????????70

<210>66

<211>2581

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>66ctttcaaccc?gcgctcgccg?gctccagccc?cgcgcgcccc?caccccttgc?cctcccggcg??????60gctccgcagg?gtgaggtggc?tttgaccccg?ggttgcccgg?ccagcacgac?cgaggaggtg?????120gctggacagc?tggaggatga?acggagaagc?cgactgcccc?acagacctgg?aaatggccgc?????180ccccaaaggc?caagaccgtt?ggtcccagga?agacatgctg?actttgctgg?aatgcatgaa?????240gaacaacctt?ccatccaatg?acagctccaa?gttcaaaacc?accgaatcac?acatggactg?????300ggaaaaagta?gcatttaaag?acttttctgg?agacatgtgc?aagctcaaat?gggtggagat?????360ttctaatgag?gtgaggaagt?tccgtacatt?gacagaattg?atcctcgatg?ctcaggaaca?????420tgttaaaaat?ccttacaaag?gcaaaaaact?caagaaacac?ccagacttcc?caaagaagcc?????480cctgacccct?tatttccgct?tcttcatgga?gaagcgggcc?aagtatgcga?aactccaccc?????540tgagatgagc?aacctggacc?taaccaagat?tctgtccaag?aaatacaagg?agcttccgga?????600gaagaagaag?atgaaatata?ttcaggactt?ccagagagag?aaacaggagt?tcgagcgaaa?????660cctggcccga?ttcagggagg?atcaccccga?cctaatccag?aatgccaaga?aatcggacat?????720cccagagaag?cccaaaaccc?cccagcagct?gtggtacacc?cacgagaaga?aggtgtatct?????780caaagtgcgg?ccagatgcca?ctacgaagga?ggtgaaggac?tccctgggga?agcagtggtc?????840tcagctctcg?gacaaaaaga?ggctgaaatg?gattcataag?gccctggagc?agcggaagga?????900gtacgaggag?atcatgagag?actatatcca?gaagcaccca?gagctgaaca?tcagtgagga?????960gggtatcacc?aagtccaccc?tcaccaaggc?cgaacgccag?ctcaaggaca?agtttgacgg????1020gcgacccacc?aagccacctc?cgaacagcta?ctcgctgtac?tgcgcagagc?tcatggccaa????1080catgaaggac?gtgcccagca?cagagcgcat?ggtgctgtgc?agccagcagt?ggaagctgct????1140gtcccagaag?gagaaggacg?cctatcacaa?gaagtgtgat?cagaaaaaga?aagattacga????1200ggtggagctg?ctccgtttcc?tcgagagcct?gcctgaggag?gagcagcagc?gggtcttggg????1260ggaagagaag?atgctgaaca?tcaacaagaa?gcaggccacc?agccccgcct?ccaagaagcc????1320agcccaggaa?gggggcaagg?gcggctccga?gaagcccaag?cggcccgtgt?cggccatgtt????1380catcttctcg?gaggagaaac?ggcggcagct?gcaggaggag?cggcctgagc?tctccgagag????1440cgagctgacc?cgcctgctgg?cccgaatgtg?gaacgacctg?tctgagaaga?agaaggccaa????1500gtacaaggcc?cgagaggcgg?cgctcaaggc?tcagtcggag?aggaagcccg?gcggggagcg????1560cgaggaacgg?ggcaagctgc?ccgagtcccc?caaaagagct?gaggagatct?ggcaacagag????1620cgttatcggc?gactacctgg?cccgcttcaa?gaatgaccgg?gtgaaggcct?tgaaagccat????1680ggaaatgacc?tggaataaca?tggaaaagaa?ggagaaactg?atgtggatta?agaaggcagc????1740cgaagaccaa?aagcgatatg?agagagagct?gagtgagatg?cgggcacctc?cagctgctac????1800aaattcttcc?aagaagatga?aattccaggg?agaacccaag?aagcctccca?tgaacggtta????1860ccagaagttc?tcccaggagc?tgctgtccaa?tggggagctg?aaccacctgc?cgctgaagga????1920gcgcatggtg?gagatcggca?gtcgctggca?gcgcatctcc?cagagccaga?aggagcacta????1980caaaaagctg?gccgaggagc?agcaaaagca?gtacaaggtg?cacctggacc?tctgggttaa????2040gagcctgtct?ccccaggacc?gtgcagcata?taaagagtac?atctccaata?aacgtaagag????2100catgaccaag?ctgcgaggcc?caaaccccaa?atccagccgg?actactctgc?agtccaagtc????2160ggagtccgag?gaggatgatg?aagaggatga?ggatgacgag?gacgaggatg?aagaagagga????2220agatgatgag?aatggggact?cctctgaaga?tggcggcgac?tcctctgagt?ccagcagcga????2280ggacgagagc?gaggatgggg?atgagaatga?agaggatgac?gaggacgaag?acgacgacga????2340ggatgacgat?gaggatgaag?ataatgagtc?cgagggcagc?agctccagct?cctcctcctt????2400aggggactcc?tcagactttg?actccaactg?aggcttagcc?ccaccccagg?ggagccaggg????2460agagcccagg?agctcccctc?cccaactgac?cacctttgtt?tcttccccat?gttctgtccc????2520ttgcccccct?ggcctccccc?actttctttc?tttctttaaa?aaaaaaaaaa?aaaaactcga????2580g????????????????????????????????????????????????????????????????????2581

<210>67

<211>764

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>67Met?Asn?Gly?Glu?Ala?Asp?Cys?Pro?Thr?Asp?Leu?Glu?Met?Ala?Ala?Pro?1???????????????5??????????????????10??????????????????15Lys?Gly?Gln?Asp?Arg?Trp?Ser?Gln?Glu?Asp?Met?Leu?Thr?Leu?Leu?Glu

20??????????????????25??????????????????30Cys?Met?Lys?Asn?Asn?Leu?Pro?Ser?Asn?Asp?Ser?Ser?Lys?Phe?Lys?Thr

35??????????????????40??????????????????45Thr?Glu?Ser?His?Met?Asp?Trp?Glu?Lys?Val?Ala?Phe?Lys?Asp?Phe?Ser

50??????????????????55??????????????????60Gly?Asp?Met?Cys?Lys?Leu?Lys?Trp?Val?Glu?Ile?Ser?Asn?Glu?Val?Arg65??????????????????70??????????????????75??????????????????80Lys?Phe?Arg?Thr?Leu?Thr?Glu?Leu?Ile?Leu?Asp?Ala?Gln?Glu?His?Val

85??????????????????90??????????????????95Lys?Asn?Pro?Tyr?Lys?Gly?Lys?Lys?Leu?Lys?Lys?His?Pro?Asp?Phe?Pro

100?????????????????105?????????????????110Lys?Lys?Pro?Leu?Thr?Pro?Tyr?Phe?Arg?Phe?Phe?Met?Glu?Lys?Arg?Ala

115?????????????????120?????????????????125Lys?Tyr?Ala?Lys?Leu?His?Pro?Glu?Met?Ser?Asn?Leu?Asp?Leu?Thr?Lys

130?????????????????135?????????????????140Ile?Leu?Ser?Lys?Lys?Tyr?Lys?Glu?Leu?Pro?Glu?Lys?Lys?Lys?Met?Lys145?????????????????150?????????????????155?????????????????160Tyr?Ile?Gln?Asp?Phe?Gln?Arg?Glu?Lys?Gln?Glu?Phe?Glu?Arg?Asn?Leu

165?????????????????170?????????????????175Ala?Arg?Phe?Arg?Glu?Asp?His?Pro?Asp?Leu?Ile?Gln?Asn?Ala?Lys?Lys

180?????????????????185?????????????????190Ser?Asp?Ile?Pro?Glu?Lys?Pro?Lys?Thr?Pro?Gln?Gln?Leu?Trp?Tyr?Thr

195?????????????????200?????????????????205His?Glu?Lys?Lys?Val?Tyr?Leu?Lys?Val?Arg?Pro?Asp?Ala?Thr?Thr?Lys

210?????????????????215?????????????????220Glu?Val?Lys?Asp?Ser?Leu?Gly?Lys?Gln?Trp?Ser?Gln?Leu?Ser?Asp?Lys225?????????????????230?????????????????235?????????????????240Lys?Arg?Leu?Lys?Trp?Ile?His?Lys?Ala?Leu?Glu?Gln?Arg?Lys?Glu?Tyr

245?????????????????250?????????????????255Glu?Glu?Ile?Met?Arg?Asp?Tyr?Ile?Gln?Lys?His?Pro?Glu?Leu?Asn?Ile

260?????????????????265?????????????????270Ser?Glu?Glu?Gly?Ile?Thr?Lys?Ser?Thr?Leu?Thr?Lys?Ala?Glu?Arg?Gln

275?????????????????280?????????????????285Leu?Lys?Asp?Lys?Phe?Asp?Gly?Arg?Pro?Thr?Lys?Pro?Pro?Pro?Asn?Ser

290?????????????????295?????????????????300Tyr?Ser?Leu?Tyr?Cys?Ala?Glu?Leu?Met?Ala?Asn?Met?Lys?Asp?Val?Pro305?????????????????310?????????????????315?????????????????320Ser?Thr?Glu?Arg?Met?Val?Leu?Cys?Ser?Gln?Gln?Trp?Lys?Leu?Leu?Ser

325?????????????????330?????????????????335Gln?Lys?Glu?Lys?Asp?Ala?Tyr?His?Lys?Lys?Cys?Asp?Gln?Lys?Lys?Lys

340?????????????????345?????????????????350Asp?Tyr?Glu?Val?Glu?Leu?Leu?Arg?Phe?Leu?Glu?Ser?Leu?Pro?Glu?Glu

355?????????????????360?????????????????365Glu?Gln?Gln?Arg?Val?Leu?Gly?Glu?Glu?Lys?Met?Leu?Asn?Ile?Asn?Lys

370?????????????????375?????????????????380Lys?Gln?Ala?Thr?Ser?Pro?Ala?Ser?Lys?Lys?Pro?Ala?Gln?Glu?Gly?Gly385?????????????????390?????????????????395?????????????????400Lys?Gly?Gly?Ser?Glu?Lys?Pro?Lys?Arg?Pro?Val?Ser?Ala?Met?Phe?Ile

405?????????????????410?????????????????415Phe?Ser?Glu?Glu?Lys?Arg?Arg?Gln?Leu?Gln?Glu?Glu?Arg?Pro?Glu?Leu

420?????????????????425?????????????????430Ser?Glu?Ser?Glu?Leu?Thr?Arg?Leu?Leu?Ala?Arg?Met?Trp?Asn?Asp?Leu

435?????????????????440?????????????????445Ser?Glu?Lys?Lys?Lys?Ala?Lys?Tyr?Lys?Ala?Arg?Glu?Ala?Ala?Leu?Lys

450?????????????????455?????????????????460Ala?Gln?Ser?Glu?Arg?Lys?Pro?Gly?Gly?Glu?Arg?Glu?Glu?Arg?Gly?Lys465?????????????????470?????????????????475?????????????????480Leu?Pro?Glu?Ser?Pro?Lys?Arg?Ala?Glu?Glu?Ile?Trp?Gln?Gln?Ser?Val

485?????????????????490?????????????????495Ile?Gly?Asp?Tyr?Leu?Ala?Arg?Phe?Lys?Asn?Asp?Arg?Val?Lys?Ala?Leu

500?????????????????505?????????????????510Lys?Ala?Met?Glu?Met?Thr?Trp?Asn?Asn?Met?Glu?Lys?Lys?Glu?Lys?Leu

515?????????????????520?????????????????525Met?Trp?Ile?Lys?Lys?Ala?Ala?Glu?Asp?Gln?Lys?Arg?Tyr?Glu?Arg?Glu

530?????????????????535?????????????????540Leu?Ser?Glu?Met?Arg?Ala?Pro?Pro?Ala?Ala?Thr?Asn?Ser?Ser?Lys?Lys545?????????????????550?????????????????555?????????????????560Met?Lys?Phe?Gln?Gly?Glu?Pro?Lys?Lys?Pro?Pro?Met?Asn?Gly?Tyr?Gln

565?????????????????570?????????????????575Lys?Phe?Ser?Gln?Glu?Leu?Leu?Ser?Asn?Gly?Glu?Leu?Asn?His?Leu?Pro

580?????????????????585?????????????????590Leu?Lys?Glu?Arg?Met?Val?Glu?Ile?Gly?Ser?Arg?Trp?Gln?Arg?Ile?Ser

595?????????????????600?????????????????605Gln?Ser?Gln?Lys?Glu?His?Tyr?Lys?Lys?Leu?Ala?Glu?Glu?Gln?Gln?Lys

610?????????????????615?????????????????620Gln?Tyr?Lys?Val?His?Leu?Asp?Leu?Trp?Val?Lys?Ser?Leu?Ser?Pro?Gln625?????????????????630?????????????????635?????????????????640Asp?Arg?Ala?Ala?Tyr?Lys?Glu?Tyr?Ile?Ser?Asn?Lys?Arg?Lys?Ser?Met

645?????????????????650?????????????????655Thr?Lys?Leu?Arg?Gly?Pro?Asn?Pro?Lys?Ser?Ser?Arg?Thr?Thr?Leu?Gln

660?????????????????665?????????????????670Ser?Lys?Ser?Glu?Ser?Glu?Glu?Asp?Asp?Glu?Glu?Asp?Glu?Asp?Asp?Glu

675?????????????????680?????????????????685Asp?Glu?Asp?Glu?Glu?Glu?Glu?Asp?Asp?Glu?Asn?Gly?Asp?Ser?Ser?Glu

690?????????????????695?????????????????700Asp?Gly?Gly?Asp?Ser?Ser?Glu?Ser?Ser?Ser?Glu?Asp?Glu?Ser?Glu?Asp705?????????????????710?????????????????715?????????????????720Gly?Asp?Glu?Asn?Glu?Glu?Asp?Asp?Glu?Asp?Glu?Asp?Asp?Asp?Glu?Asp

725?????????????????730?????????????????735Asp?Asp?Glu?Asp?Glu?Asp?Asn?Glu?Ser?Glu?Gly?Ser?Ser?Ser?Ser?Ser

740?????????????????745?????????????????750Ser?Ser?Leu?Gly?Asp?Ser?Ser?Asp?Phe?Asp?Ser?Asn

755?????????????????760

<210>68

<211>434

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>68ctaagatgct?ggatgctgaa?gacatcgtcg?gaactgcccg?gccagatgag?aaagccatta?????60tgacttatgt?gtctagcttc?tatcatgcct?tctctggagc?ccagaaggca?gaaacagcag????120ccaatcgcat?ctgcaaagtg?ttggcggtca?atcaagagaa?cgagcagctt?atggaagact????180atgagaagct?ggccagtgat?ctgttggagt?ggatccgccg?caccatccca?tggctggaga????240atcgggtgcc?tgagaacacc?atgcatgcca?tgcagcagaa?gctggaggac?ttccgagact????300atagacgcct?gcacaagccg?cccaaggtgc?aggagaagtg?ccagctggag?atcaacttta????360acacgctgca?gaccaaactg?cggctcagca?accggcctgc?cttcatgccc?tccgagggca????420ggatggtctc?ggat??????????????????????????????????????????????????????434

<210>69

<211>244

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>69aggcagcatg?ctcgttgaga?gtcatcacca?ctccctaatc?tcaagtacgc?agggacacaa?????60acactgcgga?aggccgcagg?gtcctctgcc?taggaaaacc?agagaccttt?gttcacttgt????120ttatgtgctg?accttccctc?cactattgtc?ctgtgaccct?gccaaatccc?cctttgtgag????180aaacacccaa?gaatgatcaa?taaaaaataa?attaatttag?gaaaaaaaaa?aaaaaaaact????240cgag?????????????????????????????????????????????????????????????????244

<210>70

<211>437

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>70ctgggacggg?agcgtccagc?gggactcgaa?ccccagatgt?gaaggcgttt?ctggaaagtc?????60cttggtccct?ggatccagcg?tcggccagcc?cagagcccgt?gccgcacatc?cttgcgtcct????120ccaggcagtg?ggaccccgcg?agctgcacgt?ccctgggcac?ggacaagtgt?gaggcactgt????180tggggctgtg?ccaggtgcgg?ggtgggctgc?cccctttctc?agaaccttcc?agcctggtgc????240cgtggccccc?aggccggagt?cttcctaagg?ctgtgaggcc?acccctgtcc?tggcctccgt????300tctcgcagca?gcagaccttg?cccgtgatga?gcggggaggc?ccttggctgg?ctgggccagg????360ctggttccct?ggccatgggg?gctgcacctc?tgggggagcc?agccaaggag?gaccccatgc????420tggcgcagga?agccggg???????????????????????????????????????????????????437

<210>71

<211>271

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>71gcgcagagtt?ctgtcgtcca?ccatcgagtg?aggaagagag?cattggttcc?cctgagatag?????60aagagatggc?tctcttcagt?gcccagtctc?catacattaa?cccgatcatc?ccctttactg????120gaccaatcca?aggagggctg?caggagggac?ttcaggtgac?cctccagggg?actaccgaga????180gttttgcaca?aaagtttgtg?gtgaactttt?cagaacagct?tcaatggaga?tgacttggcc????240ttccacttca?accccggtta?tgaggaagga?g???????????????????????????????????271

<210>72

<211>290

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>72ccgagcccta?cccggaggtc?tccagaatcc?ccaccgtcag?gggatgcaac?ggctccctgt?????60ctggtgccct?ctcctgctgc?gaggactcgg?cccagggctc?gggcccgccc?aaggccccta????120cggtggccga?gggtcccagc?tcctgccttc?ggcggaacgt?gatcagcgag?agggagcgca????180ggaagcggat?gtcgttgagc?tgtgagcgtc?tgcgggccct?gctgccccag?ttcgatggcc????240ggcgggagga?catggcctcg?gtcctggaga?tgtctgttgc?aattcctgcg???????????????290

<210>73

<211>144

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>73Lys?Met?Leu?Asp?Ala?Glu?Asp?Ile?Val?Gly?Thr?Ala?Arg?Pro?Asp?Glu?1???????????????5??????????????????10??????????????????15Lys?Ala?Ile?Met?Thr?Tyr?Val?Ser?Ser?Phe?Tyr?His?Ala?Phe?Ser?Gly

20??????????????????25??????????????????30Ala?Gln?Lys?Ala?Glu?Thr?Ala?Ala?Asn?Arg?Ile?Cys?Lys?Val?Leu?Ala

35??????????????????40??????????????????45Val?Asn?Gln?Glu?Asn?Glu?Gln?Leu?Met?Glu?Asp?Tyr?Glu?Lys?Leu?Ala

50??????????????????55??????????????????60Ser?Asp?Leu?Leu?Glu?Trp?Ile?Arg?Arg?Thr?Ile?Pro?Trp?Leu?Glu?Asn65??????????????????70??????????????????75??????????????????80Arg?Val?Pro?Glu?Asn?Thr?Met?His?Ala?Met?Gln?Gln?Lys?Leu?Glu?Asp

85??????????????????90??????????????????95Phe?Arg?Asp?Tyr?Arg?Arg?Leu?His?Lys?Pro?Pro?Lys?Val?Gln?Glu?Lys

100?????????????????105?????????????????110Cys?Gln?Leu?Glu?Ile?Asn?Phe?Asn?Thr?Leu?Gln?Thr?Lys?Leu?Arg?Leu

115?????????????????120?????????????????125Ser?Asn?Arg?Pro?Ala?Phe?Met?Pro?Ser?Glu?Gly?Arg?Met?Val?Ser?Asp

130?????????????????135?????????????????140

<210>74

<211>64

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>74Gly?Ser?Met?Leu?Val?Glu?Ser?His?His?His?Ser?Leu?Ile?Ser?Ser?Thr?1???????????????5??????????????????10??????????????????15Gln?Gly?His?Lys?His?Cys?Gly?Arg?Pro?Gln?Gly?Pro?Leu?Pro?Arg?Lys

20??????????????????25??????????????????30Thr?Arg?Asp?Leu?Cys?Ser?Leu?Val?Tyr?Val?Leu?Thr?Phe?Pro?Pro?Leu

35??????????????????40??????????????????45Leu?Ser?Cys?Asp?Pro?Ala?Lys?Ser?Pro?Phe?Val?Arg?Asn?Thr?Gln?Glu

50??????????????????55??????????????????60

<210>75

<211>145

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>75Gly?Thr?Gly?Ala?Ser?Ser?Gly?Thr?Arg?Thr?Pro?Asp?Val?Lys?Ala?Phe?1???????????????5??????????????????10??????????????????15Leu?Glu?Ser?Pro?Trp?Ser?Leu?Asp?Pro?Ala?Ser?Ala?Ser?Pro?Glu?Pro

20??????????????????25??????????????????30Val?Pro?His?Ile?Leu?Ala?Ser?Ser?Arg?Gln?Trp?Asp?Pro?Ala?Ser?Cys

35??????????????????40??????????????????45Thr?Ser?Leu?Gly?Thr?Asp?Lys?Cys?Glu?Ala?Leu?Leu?Gly?Leu?Cys?Gln

50??????????????????55??????????????????60Val?Arg?Gly?Gly?Leu?Pro?Pro?Phe?Ser?Glu?Pro?Ser?Ser?Leu?Val?Pro65??????????????????70??????????????????75??????????????????80Trp?Pro?Pro?Gly?Arg?Ser?Leu?Pro?Lys?Ala?Val?Arg?Pro?Pro?Leu?Ser

85??????????????????90??????????????????95Trp?Pro?Pro?Phe?Ser?Gln?Gln?Gln?Thr?Leu?Pro?Val?Met?Ser?Gly?Glu

100?????????????????105?????????????????110Ala?Leu?Gly?Trp?Leu?Gly?Gln?Ala?Gly?Ser?Leu?Ala?Met?Gly?Ala?Ala

115?????????????????120?????????????????125Pro?Leu?Gly?Glu?Pro?Ala?Lys?Glu?Asp?Pro?Met?Leu?Ala?Gln?Glu?Ala

130?????????????????135?????????????????140Gly145

<210>76

<211>69

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>76Ala?Glu?Phe?Cys?Arg?Pro?Pro?Ser?Ser?Glu?Glu?Glu?Ser?Ile?Gly?Ser?1???????????????5??????????????????10??????????????????15Pro?Glu?Ile?Glu?Glu?Met?Ala?Leu?Phe?Ser?Ala?Gln?Ser?Pro?Tyr?Ile

20??????????????????25??????????????????30Asn?Pro?Ile?Ile?Pro?Phe?Thr?Gly?Pro?Ile?Gln?Gly?Gly?Leu?Gln?Glu

35??????????????????40??????????????????45Gly?Leu?Gln?Val?Thr?Leu?Gln?Gly?Thr?Thr?Glu?Ser?Phe?Ala?Gln?Lys

50??????????????????55??????????????????60Phe?Val?Val?Asn?Phe65

<210>77

<211>96

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>77Glu?Pro?Tyr?Pro?Glu?Val?Ser?Arg?Ile?Pro?Thr?Val?Arg?Gly?Cys?Asn?1???????????????5??????????????????10??????????????????15Gly?Ser?Leu?Ser?Gly?Ala?Leu?Ser?Cys?Cys?Glu?Asp?Ser?Ala?Gln?Gly

20??????????????????25??????????????????30Ser?Gly?Pro?Pro?Lys?Ala?Pro?Thr?Val?Ala?Glu?Gly?Pro?Ser?Ser?Cys

35??????????????????40??????????????????45Leu?Arg?Arg?Asn?Val?Ile?Ser?Glu?Arg?Glu?Arg?Arg?Lys?Arg?Met?Ser

50??????????????????55??????????????????60Leu?Ser?Cys?Glu?Arg?Leu?Arg?Ala?Leu?Leu?Pro?Gln?Phe?Asp?Gly?Arg65??????????????????70??????????????????75??????????????????80Arg?Glu?Asp?Met?Ala?Ser?Val?Leu?Glu?Met?Ser?Val?Ala?Ile?Pro?Ala

85??????????????????90??????????????????95

<210>78

<211>2076

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>78agaaaaagtc?tatgtttgca?gaaatacaga?tccaagacaa?agacaggatg?ggcactgctg??????60gaaaagttat?taaatgcaaa?gcagctgtgc?tttgggagca?gaagcaaccc?ttctccattg?????120aggaaataga?agttgcccca?ccaaagacta?aagaagttcg?cattaagatt?ttggccacag?????180gaatctgtcg?cacagatgac?catgtgataa?aaggaacaat?ggtgtccaag?tttccagtga?????240ttgtgggaca?tgaggcaact?gggattgtag?agagcattgg?agaaggagtg?actacagtga?????300aaccaggtga?caaagtcatc?cctctctttc?tgccacaatg?tagagaatgc?aatgcttgtc?????360gcaacccaga?tggcaacctt?tgcattagga?gcgatattac?tggtcgtgga?gtactggctg?????420atggcaccac?cagatttaca?tgcaagggca?aaccagtcca?ccacttcatg?aacaccagta?????480catttaccga?gtacacagtg?gtggatgaat?cttctgttgc?taagattgat?gatgcagctc?????540ctcctgagaa?agtctgttta?attggctgtg?ggttttccac?tggatatggc?gctgctgtta?????600aaactggcaa?ggtcaaacct?ggttccactt?gcgtcgtctt?tggcctgaga?ggagttggcc?????660tgtcagtcat?catgggctgt?aagtcagctg?gtgcatctag?gatcattggg?attgacctca?????720acaaagacaa?atttgagaag?gccatggctg?taggtgccac?tgagtgtatc?agtcccaagg?????780actctaccaa?acccatcagt?gaggtgctgt?cagaaatgac?aggcaacaac?gtgggataca?????840cctttgaagt?tattgggcat?cttgaaacca?tgattgatgc?cctggcatcc?tgccacatga?????900actatgggac?cagcgtggtt?gtaggagttc?ctccatcagc?caagatgctc?acctatgacc?????960cgatgttgct?cttcactgga?cgcacatgga?agggatgtgt?ctttggaggt?ttgaaaagca????1020gagatgatgt?cccaaaacta?gtgactgagt?tcctggcaaa?gaaatttgac?ctggaccagt????1080tgataactca?tgtcttacca?tttaaaaaaa?tcagtgaagg?atttgagctg?ctcaattcag????1140gacaaagcat?tcgaacggtc?ctgacgtttt?gagatccaaa?gtggcaggag?gtctgtgttg????1200tcatggtgaa?ctggagtttc?tcttgtgaga?gttccctcat?ctgaaatcat?gtatctgtct????1260cacaaataca?agcataagta?gaagatttgt?tgaagacata?gaacccttat?aaagaattat????1320taacctttat?aaacatttaa?agtcttgtga?gcacctggga?attagtataa?taacaatgtt????1380aatatttttg?atttacattt?tgtaaggcta?taattgtatc?ttttaagaaa?acatacactt????1440ggatttctat?gttgaaatgg?agatttttaa?gagttttaac?cagctgctgc?agatatatat????1500ctcaaaacag?atatagcgta?taaagatata?gtaaatgcat?ctcctagagt?aatattcact????1560taacacattg?aaactattat?tttttagatt?tgaatataaa?tgtatttttt?aaacacttgt????1620tatgagttaa?cttggattac?attttgaaat?cagttcattc?catgatgcat?attactggat????1680tagattaaga?aagacagaaa?agattaaggg?acgggcacat?ttttcaacga?ttaagaatca????1740tcattacata?acttggtgaa?actgaaaaag?tatatcatat?gggtacacaa?ggctatttgc????1800cagcatatat?taatatttta?gaaaatattc?cttttgtaat?actgaatata?aacatagagc????1860tagaatcata?ttatcatact?tatcataatg?ttcaatttga?tacagtagaa?ttgcaagtcc????1920ttaagtccct?attcactgtg?cttagtagtg?actccattta?ataaaaagtg?tttttagttt????1980ttaacaacta?cactgatgta?tttatatata?tttataacat?gttaaaaatt?tttaaggaaa????2040ttaaaaatta?tataaaaaaa?aaaaaaaaaa?ctcgag??????????????????????????????2076

<210>79

<211>2790

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>79aagcagttga?gtaggcagaa?aaaagaacct?cttcattaag?gattaaaatg?tataggccag??????60cacgtgtaac?ttcgacttca?agatttctga?atccatatgt?agtatgtttc?attgtcgtcg?????120caggggtagt?gatcctggca?gtcaccatag?ctctacttgt?ttacttttta?gcttttgatc?????180aaaaatctta?cttttatagg?agcagttttc?aactcctaaa?tgttgaatat?aatagtcagt?????240taaattcacc?agctacacag?gaatacagga?ctttgagtgg?aagaattgaa?tctctgatta?????300ctaaaacatt?caaagaatca?aatttaagaa?atcagttcat?cagagctcat?gttgccaaac?????360tgaggcaaga?tggtagtggt?gtgagagcgg?atgttgtcat?gaaatttcaa?ttcactagaa?????420ataacaatgg?agcatcaatg?aaaagcagaa?ttgagtctgt?tttacgacaa?atgctgaata?????480actctggaaa?cctggaaata?aacccttcaa?ctgagataac?atcacttact?gaccaggctg?????540cagcaaattg?gcttattaat?gaatgtgggg?ccggtccaga?cctaataaca?ttgtctgagc?????600agagaatcct?tggaggcact?gaggctgagg?agggaagctg?gccgtggcaa?gtcagtctgc?????660ggctcaataa?tgcccaccac?tgtggaggca?gcctgatcaa?taacatgtgg?atcctgacag?????720cagctcactg?cttcagaagc?aactctaatc?ctcgtgactg?gattgccacg?tctggtattt?????780ccacaacatt?tcctaaacta?agaatgagag?taagaaatat?tttaattcat?aacaattata?????840aatctgcaac?tcatgaaaat?gacattgcac?ttgtgagact?tgagaacagt?gtcaccttta?????900ccaaagatat?ccatagtgtg?tgtctcccag?ctgctaccca?gaatattcca?cctggctcta?????960ctgcttatgt?aacaggatgg?ggcgctcaag?aatatgctgg?ccacacagtt?ccagagctaa????1020ggcaaggaca?ggtcagaata?ataagtaatg?atgtatgtaa?tgcaccacat?agttataatg????1080gagccatctt?gtctggaatg?ctgtgtgctg?gagtacctca?aggtggagtg?gacgcatgtc????1140agggtgactc?tggtggccca?ctagtacaag?aagactcacg?gcggctttgg?tttattgtgg????1200ggatagtaag?ctggggagat?cagtgtggcc?tgccggataa?gccaggagtg?tatactcgag????1260tgacagccta?ccttgactgg?attaggcaac?aaactgggat?ctagtgcaac?aagtgcatcc????1320ctgttgcaaa?gtctgtatgc?aggtgtgcct?gtcttaaatt?ccaaagcttt?acatttcaac????1380tgaaaaagaa?actagaaatg?tcctaattta?acatcttgtt?acataaatat?ggtttaacaa????1440acactgttta?acctttcttt?attattaaag?gttttctatt?ttctccagag?aactatatga????1500atgttgcata?gtactgtggc?tgtgtaacag?aagaaacaca?ctaaactaat?tacaaagtta????1560acaatttcat?tacagttgtg?ctaaatgccc?gtagtgagaa?gaacaggaac?cttgagcatg????1620tatagtagag?gaacctgcac?aggtctgatg?ggtcagaggg?gtcttctctg?ggtttcactg????1680aggatgagaa?gtaagcaaac?tgtggaaaca?tgcaaaggaa?aaagtgatag?aataatattc????1740aagacaaaaa?gaacagtatg?aggcaagaga?aatagtatgt?atttaaaatt?tttggttact????1800caatatctta?tacttagtat?gagtcctaaa?attaaaaatg?tgaaactgtt?gtactatacg????1860tataacctaa?ccttaattat?tctgtaagaa?catgcttcca?taggaaatag?tggataattt????1920tcagctattt?aaggcaaaag?ctaaaatagt?tcactcctca?actgagaccc?aaagaattat????1980agatattttt?catgatgacc?catgaaaaat?atcactcatc?tacataaagg?agagactata????2040tctattttat?agagaagcta?agaaatatac?ctacacaaac?ttgtcaggtg?ctttacaact????2100acatagtact?ttttaacaac?aaaataataa?ttttaagaat?gaaaaattta?atcatcggga????2160agaacgtccc?actacagact?tcctatcact?ggcagttata?tttttgagcg?taaaagggtc????2220gtcaaacgct?aaatctaagt?aatgaattga?aagtttaaag?agggggaaga?gttggtttgc????2280aaaggaaaag?tttaaatagc?ttaatatcaa?tagaatgatc?ctgaagacag?aaaaaacttt????2340gtcactcttc?ctctctcatt?ttctttctct?ctctctcccc?ttctcataca?catgcctccc????2400cgaccaaaga?atataatgta?aattaaatcc?actaaaatgt?aatggcatga?aaatctctgt????2460agtctgaatc?actaatattc?ctgagttttt?atgagctcct?agtacagcta?aagtttgcct????2520atgcatgatc?atctatgcgt?cagagcttcc?tccttctaca?agctaactcc?ctgcatctgg????2580gcatcaggac?tgctccatac?atttgctgaa?aacttcttgt?atttcctgat?gtaaaattgt????2640gcaaacacct?acaataaagc?catctacttt?tagggaaagg?gagttgaaaa?tgcaaccaac????2700tcttggcgaa?ctgtacaaac?aaatctttgc?tatactttat?ttcaaataaa?ttctttttga????2760aatgaaaaaa?aaaaaaaaaa?aaaactcgag?????????????????????????????????????2790

<210>80

<211>1460

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>80ctcaaagcag?ttgagtaggc?agaaaaaaga?acctcttcat?taaggattaa?aatgtatagg??????60ccagcacgtg?taacttcgac?ttcaagattt?ctgaatccat?atgtagtatg?tttcattgtc?????120gtcgcagggg?tagtgatcct?ggcagtcacc?atagctctac?ttgtttactt?tttagctttt?????180gatcaaaaat?cttactttta?taggagcagt?tttcaactcc?taaatgttga?atataatagt?????240cagttaaatt?caccagctac?acaggaatac?aggactttga?gtggaagaat?tgaatctctg?????300attactaaaa?cattcaaaga?atcaaattta?agaaatcagt?tcatcagagc?tcatgttgcc?????360aaactgaggc?aagatggtag?tggtgtgaga?gcggatgttg?tcatgaaatt?tcaattcact?????420agaaataaca?atggagcatc?aatgaaaagc?agaattgagt?ctgttttacg?acaaatgctg?????480aataactctg?gaaacctgga?aataaaccct?tcaactgaga?taacatcact?tactgaccag?????540gctgcagcaa?attggcttat?taatgaatgt?ggggccggtc?cagacctaat?aacattgtct?????600gagcagagaa?tccttggagg?cactgaggct?gaggagggaa?gctggccgtg?gcaagtcagt?????660ctgcggctca?ataatgccca?ccactgtgga?ggcagcctga?tcaataacat?gtggatcctg?????720acagcagctc?actgcttcag?aagcaactct?aatcctcgtg?actggattgc?cacgtctggt?????780atttccacaa?catttcctaa?actaagaatg?agagtaagaa?atattttaat?tcataacaat?????840tataaatctg?caactcatga?aaatgacatt?gcacttgtga?gacttgagaa?cagtgtcacc?????900tttaccaaag?atatccatag?tgtgtgtctc?ccagctgcta?cccagaatat?tccacctggc?????960tctactgctt?atgtaacagg?atggggcgct?caagaatatg?ctggccacac?agttccagag????1020ctaaggcaag?gacaggtcag?aataataagt?aatgatgtat?gtaatgcacc?acatagttat????1080aatggagcca?tcttgtctgg?aatgctgtgt?gctggagtac?ctcaaggtgg?agtggacgca????1140tgtcagggtg?actctggtgg?cccactagta?caagaagact?cacggcggct?ttggtttatt????1200gtggggatag?taagctgggg?agatcagtgt?ggcctgccgg?ataagccagg?agtgtatact????1260cgagtgacag?cctaccttga?ctggattagg?caacaaactg?ggatctagtg?caacaagtgc????1320atccctgttg?caaagtctgt?atgcaggtgt?gcctgtctta?aattccaaag?ctttacattt????1380caactgaaaa?agaaactaga?aatgtcctaa?tttaacatct?tgttacataa?atatggttta????1440acaaaaaaaa?aaaaaaaaaa????????????????????????????????????????????????1460

<210>81

<211>386

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>81Met?Phe?Ala?Glu?Ile?Gln?Ile?Gln?Asp?Lys?Asp?Arg?Met?Gly?Thr?Ala?1???????????????5??????????????????10??????????????????15Gly?Lys?Val?Ile?Lys?Cys?Lys?Ala?Ala?Val?Leu?Trp?Glu?Gln?Lys?Gln

20??????????????????25??????????????????30Pro?Phe?Ser?Ile?Glu?Glu?Ile?Glu?Val?Ala?Pro?Pro?Lys?Thr?Lys?Glu

35??????????????????40??????????????????45Val?Arg?Ile?Lys?Ile?Leu?Ala?Thr?Gly?Ile?Cys?Arg?Thr?Asp?Asp?His

50??????????????????55??????????????????60Val?Ile?Lys?Gly?Thr?Met?Val?Ser?Lys?Phe?Pro?Val?Ile?Val?Gly?His65??????????????????70??????????????????75??????????????????80Glu?Ala?Thr?Gly?Ile?Val?Glu?Ser?Ile?Gly?Glu?Gly?Val?Thr?Thr?Val

85??????????????????90??????????????????95Lys?Pro?Gly?Asp?Lys?Val?Ile?Pro?Leu?Phe?Leu?Pro?Gln?Cys?Arg?Glu

100?????????????????105?????????????????110Cys?Asn?Ala?Cys?Arg?Asn?Pro?Asp?Gly?Asn?Leu?Cys?Ile?Arg?Ser?Asp

115?????????????????120?????????????????125Ile?Thr?Gly?Arg?Gly?Val?Leu?Ala?Asp?Gly?Thr?Thr?Arg?Phe?Thr?Cys

130?????????????????135?????????????????140Lys?Gly?Lys?Pro?Val?His?His?Phe?Met?Asn?Thr?Ser?Thr?Phe?Thr?Glu145?????????????????150?????????????????155?????????????????160Tyr?Thr?Val?Val?Asp?Glu?Ser?Ser?Val?Ala?Lys?Ile?Asp?Asp?Ala?Ala

165?????????????????170?????????????????175Pro?Pro?G1u?Lys?Val?Cys?Leu?Ile?Gly?Cys?Gly?Phe?Ser?Thr?Gly?Tyr

180?????????????????185?????????????????190Gly?Ala?Ala?Val?Lys?Thr?Gly?Lys?Val?Lys?Pro?Gly?Ser?Thr?Cys?Val

195?????????????????200?????????????????205Val?Phe?Gly?Leu?Arg?Gly?Val?Gly?Leu?Ser?Val?Ile?Met?Gly?Cys?Lys

210?????????????????215?????????????????220Ser?Ala?Gly?Ala?Ser?Arg?Ile?Ile?Gly?Ile?Asp?Leu?Asn?Lys?Asp?Lys225?????????????????230?????????????????235?????????????????240Phe?Glu?Lys?Ala?Met?Ala?Val?Gly?Ala?Thr?Glu?Cys?Ile?Ser?Pro?Lys

245?????????????????250?????????????????255Asp?Ser?Thr?Lys?Pro?Ile?Ser?Glu?Val?Leu?Ser?Glu?Met?Thr?Gly?Asn

260?????????????????265?????????????????270Asn?Val?Gly?Tyr?Thr?Phe?Glu?Val?Ile?Gly?His?Leu?Glu?Thr?Met?Ile

275?????????????????280?????????????????285Asp?Ala?Leu?Ala?Ser?Cys?His?Met?Asn?Tyr?Gly?Thr?Ser?Val?Val?Val

290?????????????????295?????????????????300Gly?Val?Pro?Pro?Ser?Ala?Lys?Met?Leu?Thr?Tyr?Asp?Pro?Met?Leu?Leu305?????????????????310?????????????????315?????????????????320Phe?Thr?Gly?Arg?Thr?Trp?Lys?Gly?Cys?Val?Phe?Gly?Gly?Leu?Lys?Ser

325?????????????????330?????????????????335Arg?Asp?Asp?Val?Pro?Lys?Leu?Val?Thr?Glu?Phe?Leu?Ala?Lys?Lys?Phe

340?????????????????345?????????????????350Asp?Leu?Asp?Gln?Leu?Ile?Thr?His?Val?Leu?Pro?Phe?Lys?Lys?Ile?Ser

355?????????????????360?????????????????365Glu?Gly?Phe?Glu?Leu?Leu?Asn?Ser?Gly?Gln?Ser?Ile?Arg?Thr?Val?Leu

370?????????????????375?????????????????380Thr?Phe385

<210>82

<211>418

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>?82Met?Tyr?Arg?Pro?Ala?Arg?Val?Thr?Ser?Thr?Ser?Arg?Phe?Leu?Asn?Pro?1???????????????5??????????????????10??????????????????15Tyr?Val?Val?Cys?Phe?Ile?Val?Val?Ala?Gly?Val?Val?Ile?Leu?Ala?Val

20??????????????????25??????????????????30Thr?Ile?Ala?Leu?Leu?Val?Tyr?Phe?Leu?Ala?Phe?Asp?Gln?Lys?Ser?Tyr

35??????????????????40??????????????????45Phe?Tyr?Arg?Ser?Ser?Phe?Gln?Leu?Leu?Asn?Val?Glu?Tyr?Asn?Ser?Gln

50??????????????????55??????????????????60Leu?Asn?Ser?Pro?Ala?Thr?Gln?Glu?Tyr?Arg?Thr?Leu?Ser?Gly?Arg?Ile65??????????????????70??????????????????75??????????????????80Glu?Ser?Leu?Ile?Thr?Lys?Thr?Phe?Lys?Glu?Ser?Asn?Leu?Arg?Asn?Gln

85??????????????????90??????????????????95Phe?Ile?Arg?Ala?His?Val?Ala?Lys?Leu?Arg?Gln?Asp?Gly?Ser?Gly?Val

100?????????????????105?????????????????110Arg?Ala?Asp?Val?Val?Met?Lys?Phe?Gln?Phe?Thr?Arg?Asn?Asn?Asn?Gly

115?????????????????120?????????????????125Ala?Ser?Met?Lys?Ser?Arg?Ile?Glu?Ser?Val?Leu?Arg?Gln?Met?Leu?Asn

130?????????????????135?????????????????140Asn?Ser?Gly?Asn?Leu?Glu?Ile?Asn?Pro?Ser?Thr?Glu?Ile?Thr?Ser?Leu145?????????????????150?????????????????155?????????????????160Thr?Asp?Gln?Ala?Ala?Ala?Asn?Trp?Leu?Ile?Asn?Glu?Cys?Gly?Ala?Gly

165?????????????????170?????????????????175Pro?Asp?Leu?Ile?Thr?Leu?Ser?Glu?Gln?Arg?Ile?Leu?Gly?Gly?Thr?Glu

180?????????????????185?????????????????190Ala?Glu?Glu?Gly?Ser?Trp?Pro?Trp?Gln?Val?Ser?Leu?Arg?Leu?Asn?Asn

195?????????????????200?????????????????205Ala?His?His?Cys?Gly?Gly?Ser?Leu?Ile?Asn?Asn?Met?Trp?Ile?Leu?Thr

210?????????????????215?????????????????220Ala?Ala?His?Cys?Phe?Arg?Ser?Asn?Ser?Asn?Pro?Arg?Asp?Trp?Ile?Ala225?????????????????230?????????????????235?????????????????240Thr?Ser?Gly?Ile?Ser?Thr?Thr?Phe?Pro?Lys?Leu?Arg?Met?Arg?Val?Arg

245?????????????????250?????????????????255Asn?Ile?Leu?Ile?His?Asn?Asn?Tyr?Lys?Ser?Ala?Thr?His?Glu?Asn?Asp

260?????????????????265?????????????????270Ile?Ala?Leu?Val?Arg?Leu?Glu?Asn?Ser?Val?Thr?Phe?Thr?Lys?Asp?Ile

275?????????????????280?????????????????285His?Ser?Val?Cys?Leu?Pro?Ala?Ala?Thr?Gln?Asn?Ile?Pro?Pro?Gly?Ser

290?????????????????295?????????????????300Thr?Ala?Tyr?Val?Thr?Gly?Trp?Gly?Ala?Gln?Glu?Tyr?Ala?Gly?His?Thr305?????????????????310?????????????????315?????????????????320Val?Pro?Glu?Leu?Arg?Gln?Gly?Gln?Val?Arg?Ile?Ile?Ser?Asn?Asp?Val

325?????????????????330?????????????????335Cys?Asn?Ala?Pro?His?Ser?Tyr?Asn?Gly?Ala?Ile?Leu?Ser?Gly?Met?Leu

340?????????????????345?????????????????350Cys?Ala?Gly?Val?Pro?Gln?Gly?Gly?Val?Asp?Ala?Cys?Gln?Gly?Asp?Ser

355?????????????????360?????????????????365Gly?Gly?Pro?Leu?Val?Gln?Glu?Asp?Ser?Arg?Arg?Leu?Trp?Phe?Ile?Val

370?????????????????375?????????????????380Gly?Ile?Val?Ser?Trp?Gly?Asp?Gln?Cys?Gly?Leu?Pro?Asp?Lys?Pro?Gly385?????????????????390?????????????????395?????????????????400Val?Tyr?Thr?Arg?Val?Thr?Ala?Tyr?Leu?Asp?Trp?Ile?Arg?Gln?Gln?Thr

405?????????????????410?????????????????415Gly?Ile

<210>83

<211>418

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>83Met?Tyr?Arg?Pro?Ala?Arg?Val?Thr?Ser?Thr?Ser?Arg?Phe?Leu?Asn?Pro?1???????????????5??????????????????10??????????????????15Tyr?Val?Val?Cys?Phe?Ile?Val?Val?Ala?Gly?Val?Val?Ile?Leu?Ala?Val

20??????????????????25??????????????????30Thr?Ile?Ala?Leu?Leu?Val?Tyr?Phe?Leu?Ala?Phe?Asp?Gln?Lys?Ser?Tyr

35??????????????????40??????????????????45Phe?Tyr?Arg?Ser?Ser?Phe?Gln?Leu?Leu?Asn?Val?Glu?Tyr?Asn?Ser?Gln

50??????????????????55??????????????????60Leu?Asn?Ser?Pro?Ala?Thr?Gln?Glu?Tyr?Arg?Thr?Leu?Ser?Gly?Arg?Ile65??????????????????70??????????????????75??????????????????80Glu?Ser?Leu?Ile?Thr?Lys?Thr?Phe?Lys?Glu?Ser?Asn?Leu?Arg?Asn?Gln

85??????????????????90??????????????????95Phe?Ile?Arg?Ala?His?Val?Ala?Lys?Leu?Arg?Gln?Asp?Gly?Ser?Gly?Val

100?????????????????105?????????????????110Arg?Ala?Asp?Val?Val?Met?Lys?Phe?Gln?Phe?Thr?Arg?Asn?Asn?Asn?Gly

115?????????????????120?????????????????125Ala?Ser?Met?Lys?Ser?Arg?Ile?Glu?Ser?Val?Leu?Arg?Gln?Met?Leu?Asn

130?????????????????135?????????????????140Asn?Ser?Gly?Asn?Leu?Glu?Ile?Asn?Pro?Ser?Thr?Glu?Ile?Thr?Ser?Leu145?????????????????150?????????????????155?????????????????160Thr?Asp?Gln?Ala?Ala?Ala?Asn?Trp?Leu?Ile?Asn?Glu?Cys?Gly?Ala?Gly

165?????????????????170?????????????????175Pro?Asp?Leu?Ile?Thr?Leu?Ser?Glu?Gln?Arg?Ile?Leu?Gly?Gly?Thr?Glu

180?????????????????185?????????????????190Ala?Glu?Glu?Gly?Ser?Trp?Pro?Trp?Gln?Val?Ser?Leu?Arg?Leu?Asn?Asn

195?????????????????200?????????????????205Ala?His?His?Cys?Gly?Gly?Ser?Leu?Ile?Asn?Asn?Met?Trp?Ile?Leu?Thr

210?????????????????215?????????????????220Ala?Ala?His?Cys?Phe?Arg?Ser?Asn?Ser?Asn?Pro?Arg?Asp?Trp?Ile?Ala225?????????????????230?????????????????235?????????????????240Thr?Ser?Gly?Ile?Ser?Thr?Thr?Phe?Pro?Lys?Leu?Arg?Met?Arg?Val?Arg

245?????????????????250?????????????????255Asn?Ile?Leu?Ile?His?Asn?Asn?Tyr?Lys?Ser?Ala?Thr?His?Glu?Asn?Asp

260?????????????????265?????????????????270Ile?Ala?Leu?Val?Arg?Leu?Glu?Asn?Ser?Val?Thr?Phe?Thr?Lys?Asp?Ile

275?????????????????280?????????????????285His?Ser?Val?Cys?Leu?Pro?Ala?Ala?Thr?Gln?Asn?Ile?Pro?Pro?Gly?Ser

290?????????????????295?????????????????300Thr?Ala?Tyr?Val?Thr?Gly?Trp?Gly?Ala?Gln?Glu?Tyr?Ala?Gly?His?Thr305?????????????????310?????????????????315?????????????????320Val?Pro?Glu?Leu?Arg?Gln?Gly?Gln?Val?Arg?Ile?Ile?Ser?Asn?Asp?Val

325?????????????????330?????????????????335Cys?Asn?Ala?Pro?His?Ser?Tyr?Asn?Gly?Ala?Ile?Leu?Ser?Gly?Met?Leu

340?????????????????345?????????????????350Cys?Ala?Gly?Val?Pro?Gln?Gly?Gly?Val?Asp?Ala?Cys?Gln?Gly?Asp?Ser

355?????????????????360?????????????????365Gly?Gly?Pro?Leu?Val?Gln?Glu?Asp?Ser?Arg?Arg?Leu?Trp?Phe?Ile?Val

370?????????????????375?????????????????380Gly?Ile?Val?Ser?Trp?Gly?Asp?Gln?Cys?Gly?Leu?Pro?Asp?Lys?Pro?Gly385?????????????????390?????????????????395?????????????????400Val?Tyr?Thr?Arg?Val?Thr?Ala?Tyr?Leu?Asp?Trp?Ile?Arg?Gln?Gln?Thr

405?????????????????410?????????????????415Gly?Ile

<210>84

<211>489

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>84aaaagggtaa?gcttgatgat?taccaggaac?gaatgaacaa?aggggaaagg?cttaatcaag?????60atcagctgga?tgccgtttct?aagtaccagg?aagtcacaaa?taatttggag?tttgcaaaag????120aattacagag?gagtttcatg?gcactaagtc?aagatattca?gaaaacaata?aagaagacag????180cacgtcggga?gcagcttatg?agagaagaag?ctgaacagaa?acgtttaaaa?actgtacttg????240agctacagta?tgttttggac?aaattgggag?atgatgaagt?gcggactgac?ctgaaacaag????300gtttgaatgg?agtgccaata?ttgtccgaag?aggagttgtc?attgttggat?gaattctata????360agctagtaga?ccctgaacgg?gacatgagct?tgaggttgaa?tgaacagtat?gaacatgcct????420ccattcacct?gtgggacctg?ctggaaggga?aggaaaaacc?tgtatgtgga?accacctata????480aagttctaa????????????????????????????????????????????????????????????489

<210>85

<211>304

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>85gggacctgga?ggaggccacg?ctgcagcatg?aagccacagc?agccaccctg?aggaagaagc?????60acgcggacag?cgtggccgag?ctcggggagc?agatcgacaa?cctgcagcgg?gtgaagcaga????120agctggagaa?ggagaagagc?gagatgaaga?tggagatcga?tgacctcgct?tgtaacatgg????180aggtcatctc?caaatctaag?ggaaaccttg?agaagatgtg?ccgcacactg?gaggaccaag????240tgagtgagct?gaagacccag?gaggaggaac?agcagcggct?gatcaatgaa?ctgactgcgc????300agag?????????????????????????????????????????????????????????????????304

<210>86

<211>296

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>86gaaaatcctt?cctttgaatg?ggaatctcca?agcagttgaa?ttgggcgaaa?aaagaacctc?????60ttccttaagg?attaaaatgt?ttagggcaac?acgtgttact?tccacttcca?gatttctgaa????120tccatatgtt?gtatgtttcc?ttgtcctccc?aggggttgtg?atcctggcag?tccccatagc????180tctacttgtt?tactttttag?cttttgatca?aaaatcttac?ttttattgga?gcaattttcc????240actcccaaat?gttgaatata?atagtccgtt?taattccccc?gcttcaccgg?gaattc????????296

<210>87

<211>904

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>87gtgtccagga?aacgattcat?gaacataaca?agcttgctgc?aaattcagat?catctcatgc?????60agattcaaaa?atgtgagttg?gtcttgatcc?acacctaccc?agttggtgaa?gacagccttg????120tatctgatcg?ttctaaaaaa?gagttgtccc?cggttttaac?cagtgaagtt?catagtgttc????180gtgcaggacg?gcatcttgct?accaaattga?atattttagt?acagcaacat?tttgacttgg????240cttcaactac?tattacaaat?attccaatga?aggaagaaca?gcatgctaac?acatctgcca????300attatgatgt?ggagctactt?catcacaaag?atgcacatgt?agatttcctg?aaaagtggtg????360attcgcatct?aggtggcggc?agtcgagaag?gctcgtttaa?agaaacaata?acattaaagt????420ggtgtacacc?aaggacaaat?aacattgaat?tacactattg?tactggagct?tatcggattt????480cacctgtaga?tgtaaatagt?agaccttcct?cctgccttac?taattttctt?ctaaatggtc????540gttctgtttt?attggaacaa?ccacgaaagt?caggttctaa?agtcattagt?catatgctta????600gtagccatgg?aggagagatt?tttttgcacg?tccttagcag?ttctcgatcc?attctagaag????660atccaccttc?aattagtgaa?ggatgtggag?gaagagttac?agactaccgg?attacagatt????720ttggtgaatt?tatgagggga?aaacagatta?actccttttc?tacaccccag?atataaaatc????780gatggaagtc?ttgaggtccc?tttggaaccg?agccaaaaga?tcagttaaaa?aaacataccc????840gttactggcc?tatgatttca?aaaacccacc?atttttaaca?tgcaagcggt?agttccgtta????900acca?????????????????????????????????????????????????????????????????904

<210>88

<211>387

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>88cgtctctccc?ccagtttgcc?gttcacccgg?agcgctcggg?acttgccgat?agtggtgacg?????60gcggcaacat?gtctgtggct?ttcgcggccc?cgaggcagcg?aggcaagggg?gagatcactc????120ccgctgcgat?tcagaagatg?ttggatgaca?ataaccatct?tattcagtgt?ataatggact????180ctcagaataa?aggaaagacc?tcagagtgtt?ctcagtatca?gcagatgttg?cacacaaact????240tggtatacct?tgctacaata?gcagattcta?atcaaaatat?gcagtctctt?ttaccagcac????300cacccacaca?gaatatgcct?atgggtcctg?gagggatgaa?tcagagcggg?cctcccccac????360ctccacgctc?tcacaacatg?ccttcaa????????????????????????????????????????387

<210>89

<211>481

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>89tgttcttgga?cctgcggtgc?tatagagcag?gctcttctag?gttggcagtt?gccatggaat?????60ctggacccaa?aatgttggcc?cccgtttgcc?tggtggaaaa?taacaatgag?cagctattgg????120tgaaccagca?agctatacag?attcttgaaa?agatttctca?gccagtggtg?gtggtggcca????180ttgtaggact?gtaccgtaca?gggaaatcct?acttgatgaa?ccatctggca?ggacagaatc????240atggcttccc?tctgggctcc?acggtgcagt?ctgaaaccaa?gggcatctgg?atgtggtgcg????300tgccccaccc?atccaagcca?aaccacaccc?tggtccttct?ggacaccgaa?ggtctgggcg????360atgtggaaaa?gggtgaccct?aagaatgact?cctggatctt?tgccctggct?gtgctcctgt????420gcagcacctt?tgtctacaac?agcatgagca?ccatcaacca?ccaggccctg?gagcagctgc????480a????????????????????????????????????????????????????????????????????481

<210>90

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>90tgaaaactgt?tcttggacct?gcggtgctat?agagcaggtt?ggcagttgcc?atggaatctg?????60gacccaaaat?gttggccccc?gtttgcctgg?tggaaaataa?caatgagcag?ctattggtga????120accagcaagc?tatacagatt?cttgaaaaga?tttctcagcc?agtggtggtg?gtggccattg????180taggactgta?ccgtacaggg?aaatcctact?tgatgaacca?tctggcagga?cagaatcatg????240gcttccctct?gggctccacg?gtgcagtctg?aaaccaaggg?catctggatg?tggtgcgtgc????300cccacccatc?caagccaaac?cacaccctgg?tccttctgga?caccgaaggt?ctgggcgatg????360tggaaaaggg?tgaccctaag?aatgactcct?ggatctttgc?cctggctgtg?ctcctgtgca????420gcacctttgt?ctacaacagc?atgagcacca?tcaaccacca?agccctggag?cagctgcatt????480atgtgacgga?c?????????????????????????????????????????????????????????491

<210>91

<211>488

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>91ttcgacagtc?agccgcatct?tcttttgcgt?cgccagccga?gccacatcgc?tcagacacca?????60tggggaaggt?gaaggtcgga?gtcaacggat?ttggtcgtat?tgggcgcctg?gtcaccaggg????120ctgcttttaa?ctctggtaaa?gtggatattg?ttgccatcaa?tgaccccttc?attgacctca????180actacatggt?ttacatgttc?caatatgatt?ccacccatgg?caaattccat?ggcaccgtcg????240aggctgagaa?cgggaagctt?gtcatcaatg?gaaatcccat?caccatcttc?caggagcgag????300atccctccaa?aatcaagtgg?ggcgatgctg?gcgctgagta?cgtcgtggag?tccactggcg????360tcttcaccac?catggagaag?gctggggctc?atttgcaggg?gggagccaaa?agggtcatca????420tctctgcccc?tctgctgatg?ccccatgttc?gtcatgggtg?tgaaccatga?gaagtatgac????480acagcctc?????????????????????????????????????????????????????????????488

<210>92

<211>384

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>92gacagtcagc?cgcatcttct?tttgcgtcgc?cagccgagcc?acatcgctca?gacaccatgg?????60ggaaggtgaa?ggtcggagtc?aacggatttg?gtcgtattgg?gcgcctggtc?accagggctg????120cttttaactc?tggtaaagtg?gatattgttg?ccatcaatga?ccccttcatt?gacctcaact????180acatggttta?catgttccaa?tatgattcca?cccatggcaa?attccatggc?accgtcgagg????240ctgagaacgg?gaagcttgtc?atcaatggaa?atcccatcac?catcttccag?gagcgagatc????300cctccaaaat?caagtggggc?gatactggcg?ctgagtacgt?cgtggagtcc?actggcgtct????360tcaccaccat?ggagaaggct?gggg???????????????????????????????????????????384

<210>93

<211>162

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>93Lys?Gly?Lys?Leu?Asp?Asp?Tyr?Gln?Glu?Arg?Met?Asn?Lys?Gly?Glu?Arg?1???????????????5??????????????????10??????????????????15Leu?Asn?Gln?Asp?Gln?Leu?Asp?Ala?Val?Ser?Lys?Tyr?Gln?Glu?Val?Thr

20??????????????????25??????????????????30Asn?Asn?Leu?Glu?Phe?Ala?Lys?Glu?Leu?Gln?Arg?Ser?Phe?Met?Ala?Leu

35??????????????????40??????????????????45Ser?Gln?Asp?Ile?Gln?Lys?Thr?Ile?Lys?Lys?Thr?Ala?Arg?Arg?Glu?Gln

50??????????????????55??????????????????60Leu?Met?Arg?Glu?Glu?Ala?Glu?Gln?Lys?Arg?Leu?Lys?Thr?Val?Leu?Glu65??????????????????70??????????????????75??????????????????80Leu?Gln?Tyr?Val?Leu?Asp?Lys?Leu?Gly?Asp?Asp?Glu?Val?Arg?Thr?Asp

85??????????????????90??????????????????95Leu?Lys?Gln?Gly?Leu?Asn?Gly?Val?Pro?Ile?Leu?Ser?Glu?Glu?Glu?Leu

100?????????????????105?????????????????110Ser?Leu?Leu?Asp?Glu?Phe?Tyr?Lys?Leu?Val?Asp?Pro?Glu?Arg?Asp?Met

115?????????????????120?????????????????125Ser?Leu?Arg?Leu?Asn?Glu?Gln?Tyr?Glu?His?Ala?Ser?Ile?His?Leu?Trp

130?????????????????135?????????????????140Asp?Leu?Leu?Glu?Gly?Lys?Glu?Lys?Pro?Val?Cys?Gly?Thr?Thr?Tyr?Lys145?????????????????150?????????????????155?????????????????160Val?Leu

<210>94

<211>100

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>94Asp?Leu?Glu?Glu?Ala?Thr?Leu?Gln?His?Glu?Ala?Thr?Ala?Ala?Thr?Leu?l???????????????5??????????????????10??????????????????15Arg?Lys?Lys?His?Ala?Asp?Ser?Val?Ala?Glu?Leu?Gly?Glu?Gln?Ile?Asp

20??????????????????25??????????????????30Asn?Leu?Gln?Arg?Val?Lys?Gln?Lys?Leu?Glu?Lys?Glu?Lys?Ser?Glu?Met

35??????????????????40??????????????????45Lys?Met?Glu?Ile?Asp?Asp?Leu?Ala?Cys?Asn?Met?Glu?Val?Ile?Ser?Lys

50??????????????????55??????????????????60Ser?Lys?Gly?Asn?Leu?Glu?Lys?Met?Cys?Arg?Thr?Leu?Glu?Asp?Gln?Val65??????????????????70??????????????????75??????????????????80Ser?Glu?Leu?Lys?Thr?Gln?Glu?Glu?Glu?Gln?Gln?Arg?Leu?Ile?Asn?Glu

85??????????????????90??????????????????95Leu?Thr?Ala?Gln

100

<210>95

<211>99

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>95Lys?Ile?Leu?Pro?Leu?Asn?Gly?Asn?Leu?Gln?Ala?Val?Glu?Leu?Gly?Glu?1???????????????5??????????????????10??????????????????15Lys?Arg?Thr?Ser?Ser?Leu?Arg?Ile?Lys?Met?Phe?Arg?Ala?Thr?Arg?Val

20??????????????????25??????????????????30Thr?Ser?Thr?Ser?Arg?Phe?Leu?Asn?Pro?Tyr?Val?Val?Cys?Phe?Leu?Val

35??????????????????40??????????????????45Leu?Pro?Gly?Val?Val?Ile?Leu?Ala?Val?Pro?Ile?Ala?Leu?Leu?Val?Tyr

50??????????????????55??????????????????60Phe?Leu?Ala?Phe?Asp?Gln?Lys?Ser?Tyr?Phe?Tyr?Trp?Ser?Asn?Phe?Pro65??????????????????70??????????????????75??????????????????80Leu?Pro?Asn?Val?Glu?Tyr?Asn?Ser?Pro?Phe?Asn?Ser?Pro?Ala?Ser?Pro

85??????????????????90??????????????????95Gly?Ile?Pro

<210>96

<211>257

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>96Val?Gln?Glu?Thr?Ile?His?Glu?His?Asn?Lys?Leu?Ala?Ala?Asn?Ser?Asp?1???????????????5??????????????????10??????????????????15His?Leu?Met?Gln?Ile?Gln?Lys?Cys?Glu?Leu?Val?Leu?Ile?His?Thr?Tyr

20??????????????????25??????????????????30Pro?Val?Gly?Glu?Asp?Ser?Leu?Val?Ser?Asp?Arg?Ser?Lys?Lys?Glu?Leu

35??????????????????40??????????????????45Ser?Pro?Val?Leu?Thr?Ser?Glu?Val?His?Ser?Val?Arg?Ala?Gly?Arg?His

50??????????????????55??????????????????60Leu?Ala?Thr?Lys?Leu?Asn?Ile?Leu?Val?Gln?Gln?His?Phe?Asp?Leu?Ala65??????????????????70??????????????????75??????????????????80Ser?Thr?Thr?Ile?Thr?Asn?Ile?Pro?Met?Lys?Glu?Glu?Gln?His?Ala?Asn

85??????????????????90??????????????????95Thr?Ser?Ala?Asn?Tyr?Asp?Val?Glu?Leu?Leu?His?His?Lys?Asp?Ala?His

100?????????????????105?????????????????ll0Val?Asp?Phe?Leu?Lys?Ser?Gly?Asp?Ser?His?Leu?Gly?Gly?Gly?Ser?Arg

115?????????????????120?????????????????125Glu?Gly?Ser?Phe?Lys?Glu?Thr?Ile?Thr?Leu?Lys?Trp?Cys?Thr?Pro?Arg

130?????????????????135?????????????????140Thr?Asn?Asn?Ile?Glu?Leu?His?Tyr?Cys?Thr?Gly?Ala?Tyr?Arg?Ile?Ser145?????????????????150?????????????????155?????????????????160Pro?Val?Asp?Val?Asn?Ser?Arg?Pro?Ser?Ser?Cys?Leu?Thr?Asn?Phe?Leu

165?????????????????170?????????????????175Leu?Asn?Gly?Arg?Ser?Val?Leu?Leu?Glu?Gln?Pro?Arg?Lys?Ser?Gly?Ser

180?????????????????185?????????????????190Lys?Val?Ile?Ser?His?Met?Leu?Ser?Ser?His?Gly?Gly?Glu?Ile?Phe?Leu

195?????????????????200?????????????????205His?Val?Leu?Ser?Ser?Ser?Arg?Ser?Ile?Leu?Glu?Asp?Pro?Pro?Ser?Ile

210?????????????????215?????????????????220Ser?Glu?Gly?Cys?Gly?Gly?Arg?Val?Thr?Asp?Tyr?Arg?Ile?Thr?Asp?Phe225?????????????????230?????????????????235?????????????????240Gly?Glu?Phe?Met?Arg?Gly?Lys?Gln?Ile?Asn?Ser?Phe?Ser?Thr?Pro?Gln

245?????????????????250?????????????????255Ile

<210>97

<211>128

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>97Ser?Leu?Pro?Gln?Phe?Ala?Val?His?Pro?Glu?Arg?Ser?Gly?Leu?Ala?Asp?1???????????????5??????????????????10??????????????????15Ser?Gly?Asp?Gly?Gly?Asn?Met?Ser?Val?Ala?Phe?Ala?Ala?Pro?Arg?Gln

20??????????????????25??????????????????30Arg?Gly?Lys?Gly?Glu?Ile?Thr?Pro?Ala?Ala?Ile?Gln?Lys?Met?Leu?Asp

35??????????????????40??????????????????45Asp?Asn?Asn?His?Leu?Ile?Gln?Cys?Ile?Met?Asp?Ser?Gln?Asn?Lys?Gly

50??????????????????55??????????????????60Lys?Thr?Ser?Glu?Cys?Ser?Gln?Tyr?Gln?Gln?Met?Leu?His?Thr?Asn?Leu65??????????????????70??????????????????75??????????????????80Val?Tyr?Leu?Ala?Thr?Ile?Ala?Asp?Ser?Asn?Gln?Asn?Met?Gln?Ser?Leu

85??????????????????90??????????????????95Leu?Pro?Ala?Pro?Pro?Thr?Gln?Asn?Met?Pro?Met?Gly?Pro?Gly?Gly?Met

100?????????????????105?????????????????1l0Asn?Gln?Ser?Gly?Pro?Pro?Pro?Pro?Pro?Arg?Ser?His?Asn?Met?Pro?Ser

115?????????????????120?????????????????125

<210>98

<211>159

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>98Phe?Leu?Asp?Leu?Arg?Cys?Tyr?Arg?Ala?Gly?Ser?Ser?Arg?Leu?Ala?Val?1???????????????5??????????????????10??????????????????15Ala?Met?Glu?Ser?Gly?Pro?Lys?Met?Leu?Ala?Pro?Val?Cys?Leu?Val?Glu

20??????????????????25??????????????????30Asn?Asn?Asn?Glu?Gln?Leu?Leu?Val?Asn?Gln?Gln?Ala?Ile?Gln?Ile?Leu

35??????????????????40??????????????????45Glu?Lys?Ile?Ser?Gln?Pro?Val?Val?Val?Val?Ala?Ile?Val?Gly?Leu?Tyr

50??????????????????55??????????????????60Arg?Thr?Gly?Lys?Ser?Tyr?Leu?Met?Asn?His?Leu?Ala?Gly?Gln?Asn?His65??????????????????70??????????????????75??????????????????80Gly?Phe?Pro?Leu?Gly?Ser?Thr?Val?Gln?Ser?Glu?Thr?Lys?Gly?Ile?Trp

85??????????????????90??????????????????95??Met?Trp?Cys?Val?Pro?His?Pro?Ser?Lys?Pro?Asn?His?Thr?Leu?Val?Leu

100?????????????????105?????????????????110Leu?Asp?Thr?Glu?Gly?Leu?Gly?Asp?Val?Glu?Lys?Gly?Asp?Pro?Lys?Asn

115?????????????????120?????????????????125Asp?Ser?Trp?Ile?Phe?Ala?Leu?Ala?Val?Leu?Leu?Cys?Ser?Thr?Phe?Val

130?????????????????135?????????????????140Tyr?Asn?Ser?Met?Ser?Thr?Ile?Asn?His?Gln?Ala?Leu?Glu?Gln?Leu145?????????????????150?????????????????155

<210>99

<21l>147

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>99Met?Glu?Ser?Gly?Pro?Lys?Met?Leu?Ala?Pro?Val?Cys?Leu?Val?Glu?Asn?l???????????????5??????????????????10??????????????????15Asn?Asn?Glu?Gln?Leu?Leu?Val?Asn?Gln?Gln?Ala?Ile?Gln?Ile?Leu?Glu

20??????????????????25??????????????????30Lys?Ile?Ser?Gln?Pro?Val?Val?Val?Val?Ala?Ile?Val?Gly?Leu?Tyr?Arg

35??????????????????40??????????????????45Thr?Gly?Lys?Ser?Tyr?Leu?Met?Asn?His?Leu?Ala?Gly?Gln?Asn?His?Gly

50??????????????????55??????????????????60Phe?Pro?Leu?Gly?Ser?Thr?Val?Gln?Ser?Glu?Thr?Lys?Gly?Ile?Trp?Met65??????????????????70??????????????????75??????????????????80Trp?Cys?Val?Pro?His?Pro?Ser?Lys?Pro?Asn?His?Thr?Leu?Val?Leu?Leu

85??????????????????90??????????????????95Asp?Thr?Glu?Gly?Leu?Gly?Asp?Val?Glu?Lys?Gly?Asp?Pro?Lys?Asn?Asp

100?????????????????105?????????????????110Ser?Trp?Ile?Phe?Ala?Leu?Ala?Val?Leu?Leu?Cys?Ser?Thr?Phe?Val?Tyr

115?????????????????120?????????????????125Asn?Ser?Met?Ser?Thr?Ile?Asn?His?Gln?Ala?Leu?Glu?Gln?Leu?His?Tyr

130?????????????????135?????????????????140Val?Thr?Asp145

<210>100

<211>124

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>100Met?Gly?Lys?Val?Lys?Val?Gly?Val?Asn?Gly?Phe?Gly?Arg?Ile?Gly?Arg?1???????????????5??????????????????10??????????????????15Leu?Val?Thr?Arg?Ala?Ala?Phe?Asn?Ser?Gly?Lys?Val?Asp?Ile?Val?Ala

20??????????????????25??????????????????30Ile?Asn?Asp?Pro?Phe?Ile?Asp?Leu?Asn?Tyr?Met?Val?Tyr?Met?Phe?Gln

35??????????????????40??????????????????45Tyr?Asp?Ser?Thr?His?Gly?Lys?Phe?His?Gly?Thr?Val?Glu?Ala?Glu?Asn

50??????????????????55??????????????????60Gly?Lys?Leu?Val?Ile?Asn?Gly?Asn?Pro?Ile?Thr?Ile?Phe?Gln?Glu?Arg65??????????????????70??????????????????75??????????????????80Asp?Pro?Ser?Lys?Ile?Lys?Trp?Gly?Asp?Ala?Gly?Ala?Glu?Tyr?Val?Val

85??????????????????90??????????????????95Glu?Ser?Thr?Gly?Val?Phe?Thr?Thr?Met?Glu?Lys?Ala?Gly?Ala?His?Leu

100?????????????????105?????????????????110Gln?Gly?Gly?Ala?Lys?Arg?Val?Ile?Ile?Ser?Ala?Pro

115?????????????????120

<210>101

<211>127

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>101Gln?Ser?Ala?Ala?Ser?Ser?Phe?Ala?Ser?Pro?Ala?Glu?Pro?His?Arg?Ser?1???????????????5??????????????????10??????????????????15Asp?Thr?Met?Gly?Lys?Val?Lys?Val?Gly?Val?Asn?Gly?Phe?Gly?Arg?Ile

20??????????????????25??????????????????30Gly?Arg?Leu?Val?Thr?Arg?Ala?Ala?Phe?Asn?Ser?Gly?Lys?Val?Asp?Ile

35??????????????????40??????????????????45Val?Ala?Ile?Asn?Asp?Pro?Phe?Ile?Asp?Leu?Asn?Tyr?Met?Val?Tyr?Met

50??????????????????55??????????????????60Phe?Gln?Tyr?Asp?Ser?Thr?His?Gly?Lys?Phe?His?Gly?Thr?Val?Glu?Ala65??????????????????70??????????????????75??????????????????80Glu?Asn?Gly?Lys?Leu?Val?Ile?Asn?Gly?Asn?Pro?Ile?Thr?Ile?Phe?Gln

85??????????????????90??????????????????95Glu?Arg?Asp?Pro?Ser?Lys?Ile?Lys?Trp?Gly?Asp?Thr?Gly?Ala?Glu?Tyr

100?????????????????105?????????????????110Val?Val?Glu?Ser?Thr?Gly?Val?Phe?Thr?Thr?Met?Glu?Lys?Ala?Gly

115?????????????????120?????????????????125

<210>102

<211>1225

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>102atggcggcgc?ggtcgtcgtc?gggggtggcg?gcggcagagg?gggcggcggc?cctggcggca??????60gcggagacgg?cagccgtgac?ggtggcagcg?gcggcgcggg?acctgggcct?gggggaatga?????120ggcggccgcg?gcgggccagc?ggcggagccg?tgtagcggag?aagctccccc?tccctgcttc?????180ccttggccga?gccgggggcg?cgcgcgcacg?cggccgtcca?gagcgggctc?cccacccctc?????240gactcctgcg?acccgcaccg?cacccccacc?cgggcccgga?ggatgatgaa?gctcaagtcg?????300aaccagaccc?gcacctacga?cggcgacggc?tacaagaagc?gggccgcatg?cctgtgtttc?????360cgcagcgaga?gcgaggagga?ggtgctactc?gtgagcagta?gtcgccatcc?agacagatgg?????420attgtccctg?gaggaggcat?ggagcccgag?gaggagccaa?gtgtggcagc?agttcgtgaa?????480gtctgtgagg?aggctggagt?aaaagggaca?ttgggaagat?tagttggaat?ttttgagaac?????540caggagagga?agcacaggac?gtatgtctat?gtgctcattg?tcactgaagt?gctggaagac?????600tgggaagatt?cagttaacat?tggaaggaag?agggaatggt?ttaaaataga?agacgccata?????660aaagtgctgc?agtatcacaa?acccgtgcag?gcatcatatt?ttgaaacatt?gaggcaaggc?????720tactcagcca?acaatggcac?cccagtcgtg?gccaccacat?actcggtttc?tgctcagagc?????780tcgatgtcag?gcatcagatg?actgaagact?tcctgtaaga?gaaatggaaa?ttggaaacta?????840gactgaagtg?caaatcttcc?ctctcaccct?ggctctttcc?acttctcaca?ggcctcctct?????900ttcaaataag?gcatggtggg?cagcaaagaa?agggtgtatt?gataatgttg?ctgtttggtg?????960ttaagtgatg?gggctttttc?ttctgttttt?attgagggtg?ggggttgggt?gtgtaatttg????1020taagtacttt?tgtgcatgat?ctgtccctcc?ctcttcccac?ccctgcagtc?ctctgaagag????1080aggccaacag?ccttcccctg?ccttggattc?tgaagtgttc?ctgtttgtct?tatcctggcc????1140ctggccagac?gttttctttg?atttttaatt?tttttttttt?attaaaagat?accagtatga????1200gaaaaaaaaa?aaaaaaaaac?tcgag??????????????????????????????????????????1225

<210>103

<211>741

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>103agaaacctca?atcggattca?gcaaaggaat?ggtgttatta?tcactacata?ccaaatgtta?????60atcaataact?ggcagcaact?ttcaagcttt?aggggccaag?agtttgtgtg?ggactatgtc????120atcctcgatg?aagcacataa?aataaaaacc?tcatctacta?agtcagcaat?atgtgctcgt????180gctattcctg?caagtaatcg?cctcctcctc?acaggaaccc?caatccagaa?taatttacaa????240gaactatggt?ccctatttga?ttttgcttgt?caagggtccc?tgctgggaac?attaaaaact????300tttaagatgg?agtatgaaaa?tcctattact?agagcaagag?agaaggatgc?taccccagga????360gaaaaagcct?tgggatttaa?aatatctgaa?aacttaatgg?caatcataaa?accctatttt????420ctcaggagga?ctaaagaaga?cgtacagaag?aaaaagtcaa?gcaacccaga?ggccagactt????480aatgaaaaga?atccagatgt?tgatgccatt?tgtgaaatgc?cttccctttc?caggagaaat????540gatttaatta?tttggatacg?acttgtgcct?ttacaagaag?aaatatacag?gaaatttgtg????600tctttagatc?atatcaagga?gttgctaatg?gagacgcgct?cacctttggc?tgagctaggt????660gtcttaaaga?agctgtgtga?tcatcctagg?ctgctgtctg?cacgggcttg?ttgtttgcta????720aatcttggga?cattctctgc?t??????????????????????????????????????????????741

<210>104

<211>321

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>104ttgctctgcg?tcatcaaaga?caccaaactg?ctgtgctata?aaagttccaa?ggaccagcag?????60cctcagatgg?aactgccact?ccaaggctgt?aacattacgt?acatcccgaa?agacagcaaa????120aagaagaagc?acgagctgaa?gattactcag?cagggcacgg?acccgcttgt?tctcgccgtc????180cagagcaagg?aacaggccga?gcagtggctg?aaggtgatca?aagaagccta?cagtggttgt????240agtggccccg?tggattcaga?gtgtcctcct?ccaccaagct?ccccggtgca?caaggcagaa????300ctggagaaga?aactgtcttc?a??????????????????????????????????????????????321

<210>105

<211>389

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>105cagcactggc?cacactataa?aattcaggtt?cagaaaaaca?gggtaagtca?cagacagcaa?????60cgcttccagc?atttattttc?tttgcaccca?tgggcaattt?gagaaaattt?acctttagaa????120cgaactctgt?taaaggtaca?gacagtacaa?tactttttat?tcagaaggtt?tctgcataaa????180ggtgatagtc?ttttgactta?atatattatt?gtctcctgcc?ttgtgtttct?ggaatgaatg????240aaggtcatta?tttagaagat?aatctgggtt?gtatttgtgt?cgtcagattg?aattttcatt????300gcacatgcta?cttaatgtct?ttaccaaata?ataacaaagg?gaaagaaaac?caaatataga????360tgtataataa?ggaaaagctg?gcctataga??????????????????????????????????????389

<210>106

<211>446

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>106gccacatttg?ccctggtcat?agtttaaaca?ccaggtcctg?tgtcacatct?ttttggtgcc?????60acaagtatca?ctccattgtt?cagagagtaa?tgtattagtt?ctgcccaatt?cattcttcac????120ttttatttct?tccatttcat?tagcatttat?atcagctcaa?gaagttaagg?ttagaaaatt????180ttccacttca?aattttcagt?acagaaatgt?gctgtgatgt?ttgacaagac?tatttcatag????240taagtgagtt?aatgtttatt?ggcctctgct?ctcctctgtg?tcagacctag?gaagcctgag????300gattacttag?ttgttctgtc?tctgggtcca?caggcagaat?ttggcccatc?caaagactgg????360ccaagtgcca?aaaaaaggcc?tgattaggcc?ctgaaattca?gtgaaattct?gcctgaagaa????420acctcttatt?gaatttgaaa?accata?????????????????????????????????????????446

<210>107

<211>467

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>107ccgccgctgc?cgtcgccttc?ctgggattgg?agtctcgagc?tttcttcgtt?cgttcgccgg?????60cgggttcgcg?cccttctcgc?gcctcggggc?tgcgaggctg?gggaaggggt?tggagggggc????120tgttgatcgc?cgcgtttaag?ttgcgctcgg?ggcggccatg?tcggccggcg?aggtcgagcg????180cctagtgtcg?gagctgagcg?gcgggaccgg?aggggatgag?gaggaagagt?ggctctatgg????240cgatgaagat?gaagttgaaa?ggccagaaga?agaaaatgcc?agtgctaatc?ctccatctgg????300aattgaagat?gaaactgctg?aaaatggtgt?accaaaaccg?aaagtgactg?agaccgaaga????360tgatagtgat?agtgacagcg?atgatgatga?agatgatgtg?catgtcacta?taggagacat????420taaaacggga?gcaccacagt?atgggagtta?tggtacagca?cctgtaa??????????????????467

<210>108

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>108gaaagataca?acttccccaa?cccaaacccg?tttgtggagg?acgacatgga?taagaatgaa?????60atcgcctctg?ttgcgtaccg?ttaccgcagg?tggaagcttg?gagatgatat?tgaccttatt????120gtccgttgtg?agcacgatgg?cgtcatgact?ggagccaacg?gggaagtgtc?cttcatcaac????180atcaagacac?tcaatgagtg?ggattccagg?cactgtaatg?gcgttgactg?gcgtcagaag????240ctggactctc?agcgaggggc?tgtcattgcc?acggagctga?agaacaacag?ctacaagttg????300gcccggtgga?cctgctgtgc?tttgctggct?ggatctgagt?acctcaagct?tggttatgtg????360tctcggtacc?acgtgaaaga?ctcctcacgc?cacgtcatcc?taggcaccca?gcagttcaag????420cctaatgagt?ttgccagcca?gatcaacctg?agcgtggaga?atgcctgagg?cattttacgc????480tgcgtcattg?a?????????????????????????????????????????????????????????491

<210>109

<211>489

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>109ctcagatagt?actgaaccct?ttatcaacta?tgttttttca?gtctgacaac?caaggcggct?????60actaagtgac?taaggggcag?gtagtataca?gtgtggataa?gcaggacaaa?ggggtgattc????120acatcccagg?caggacagag?caggagatca?tgagatttca?tcactcagga?tggcttgtga????180tttattttat?tttattcttt?tttttttttg?agatggagtc?tcactcttgc?ccaggctgga????240gtgcagtggt?gcgatcttgg?ctcactgcaa?cctctgcctc?ctgggttcaa?gcagttctcc????300tgcctcagcc?tcccaagtag?ctgggattac?aggcgtccgc?caccatgccc?agccaatttt????360tgtactttta?gtagagatgg?ggtttcacca?tgttggccag?gctggtctcg?aactcctgac????420ctcaggtgat?ccactcgcct?cggcctccca?aagtgctggg?attataggca?tgcgccacca????480tgcccgggc????????????????????????????????????????????????????????????489

<210>110

<211>391

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>110gcggagtccg?ctggctgacc?cgagcgctgg?tctccgccgg?gaaccctggg?gcatggagag?????60gtctgagtac?ctcggccgcg?gcgcacgctg?catcgcggag?ccaggctgcc?gctgtcccag????120tggagttcca?ggagcaccac?ctgagtgagg?tgcagaatat?ggcatctgag?gagaagctgg????180agcaggtgct?gagttccatg?aaggagaaca?aagtggccat?cattggaaag?attcataccc????240cgatggagta?taagggggag?ctagcctcct?atgatatgcg?gctgaggcgt?aagttggact????300tatttgccaa?cgtaatccat?gtgaagtcac?ttcctgggta?tatgactcgg?cacaacaatc????360tagacctggt?gatcattcga?gagcagacag?a???????????????????????????????????391

<210>111

<211>172

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>111Met?Met?Lys?Leu?Lys?Ser?Asn?Gln?Thr?Arg?Thr?Tyr?Asp?Gly?Asp?Gly?1???????????????5??????????????????10??????????????????15Tyr?Lys?Lys?Arg?Ala?Ala?Cys?Leu?Cys?Phe?Arg?Ser?Glu?Ser?Glu?Glu

20??????????????????25??????????????????30Glu?Val?Leu?Leu?Val?Ser?Ser?Ser?Arg?His?Pro?Asp?Arg?Trp?Ile?Val

35??????????????????40??????????????????45Pro?Gly?Gly?Gly?Met?Glu?Pro?Glu?Glu?Glu?Pro?Ser?Val?Ala?Ala?Val

50??????????????????55??????????????????60Arg?Glu?Val?Cys?Glu?Glu?Ala?Gly?Val?Lys?Gly?Thr?Leu?Gly?Arg?Leu65??????????????????70??????????????????75??????????????????80Val?Gly?Ile?Phe?Glu?Asn?Gln?Glu?Arg?Lys?His?Arg?Thr?Tyr?Val?Tyr

85??????????????????90??????????????????95Val?Leu?Ile?Val?Thr?Glu?Val?Leu?Glu?Asp?Trp?Glu?Asp?Ser?Val?Asn

100?????????????????105?????????????????110Ile?Gly?Arg?Lys?Arg?Glu?Trp?Phe?Lys?Ile?Glu?Asp?Ala?Ile?Lys?Val

115?????????????????120?????????????????125Leu?Gln?Tyr?His?Lys?Pro?Val?Gln?Ala?Ser?Tyr?Phe?Glu?Thr?Leu?Arg

130?????????????????135?????????????????140Gln?Gly?Tyr?Ser?Ala?Asn?Asn?Gly?Thr?Pro?Val?Val?Ala?Thr?Thr?Tyr145?????????????????150?????????????????155?????????????????160Ser?Val?Ser?Ala?Gln?Ser?Ser?Met?Ser?Gly?Ile?Arg

165?????????????????170

<210>112

<211>247

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>112Arg?Asn?Leu?Asn?Arg?Ile?Gln?Gln?Arg?Asn?Gly?Val?Ile?Ile?Thr?Thr?1???????????????5??????????????????10??????????????????15Tyr?Gln?Met?Leu?Ile?Asn?Asn?Trp?Gln?Gln?Leu?Ser?Ser?Phe?Arg?Gly

20??????????????????25??????????????????30Gln?Glu?Phe?Val?Trp?Asp?Tyr?Val?Ile?Leu?Asp?Glu?Ala?His?Lys?Ile

35??????????????????40??????????????????45Lys?Thr?Ser?Ser?Thr?Lys?Ser?Ala?Ile?Cys?Ala?Arg?Ala?Ile?Pro?Ala

50??????????????????55??????????????????60Ser?Asn?Arg?Leu?Leu?Leu?Thr?Gly?Thr?Pro?Ile?Gln?Asn?Asn?Leu?Gln65??????????????????70??????????????????75??????????????????80Glu?Leu?Trp?Ser?Leu?Phe?Asp?Phe?Ala?Cys?Gln?Gly?Ser?Leu?Leu?Gly

85??????????????????90??????????????????95Thr?Leu?Lys?Thr?Phe?Lys?Met?Glu?Tyr?Glu?Asn?Pro?Ile?Thr?Arg?Ala

100?????????????????105?????????????????110Arg?Glu?Lys?Asp?Ala?Thr?Pro?Gly?Glu?Lys?Ala?Leu?Gly?Phe?Lys?Ile

115?????????????????120?????????????????125Ser?Glu?Asn?Leu?Met?Ala?Ile?Ile?Lys?Pro?Tyr?Phe?Leu?Arg?Arg?Thr

130?????????????????135?????????????????140Lys?Glu?Asp?Val?Gln?Lys?Lys?Lys?Ser?Ser?Asn?Pro?Glu?Ala?Arg?Leu145?????????????????150?????????????????155?????????????????160Asn?Glu?Lys?Asn?Pro?Asp?Val?Asp?Ala?Ile?Cys?Glu?Met?Pro?Ser?Leu

165?????????????????170?????????????????175Ser?Arg?Arg?Asn?Asp?Leu?Ile?Ile?Trp?Ile?Arg?Leu?Val?Pro?Leu?Gln

180?????????????????185?????????????????190Glu?Glu?Ile?Tyr?Arg?Lys?Phe?Val?Ser?Leu?Asp?His?Ile?Lys?Glu?Leu

195?????????????????200?????????????????205Leu?Met?Glu?Thr?Arg?Ser?Pro?Leu?Ala?Glu?Leu?Gly?Val?Leu?Lys?Lys

210?????????????????215?????????????????220Leu?Cys?Asp?His?Pro?Arg?Leu?Leu?Ser?Ala?Arg?Ala?Cys?Cys?Leu?Leu225?????????????????230?????????????????235?????????????????240Asn?Leu?Gly?Thr?Phe?Ser?Ala

245

<210>113

<211>107

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>113Leu?Leu?Cys?Val?Ile?Lys?Asp?Thr?Lys?Leu?Leu?Cys?Tyr?Lys?Ser?Ser?1???????????????5??????????????????10??????????????????15Lys?Asp?Gln?Gln?Pro?Gln?Met?Glu?Leu?Pro?Leu?Gln?Gly?Cys?Asn?Ile

20??????????????????25??????????????????30Thr?Tyr?Ile?Pro?Lys?Asp?Ser?Lys?Lys?Lys?Lys?His?Glu?Leu?Lys?Ile

35??????????????????40??????????????????45Thr?Gln?Gln?Gly?Thr?Asp?Pro?Leu?Val?Leu?Ala?Val?Gln?Ser?Lys?Glu

50??????????????????55??????????????????60Gln?Ala?Glu?Gln?Trp?Leu?Lys?Val?Ile?Lys?Glu?Ala?Tyr?Ser?Gly?Cys65??????????????????70??????????????????75??????????????????80Ser?Gly?Pro?Val?Asp?Ser?Glu?Cys?Pro?Pro?Pro?Pro?Ser?Ser?Pro?Val

85??????????????????90??????????????????95His?Lys?Ala?Glu?Leu?Glu?Lys?Lys?Leu?Ser?Ser

100?????????????????105

<210>114

<211>155

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>114Glu?Arg?Tyr?Asn?Phe?Pro?Asn?Pro?Asn?Pro?Phe?Val?Glu?Asp?Asp?Met?1???????????????5??????????????????10??????????????????15Asp?Lys?Asn?Glu?Ile?Ala?Ser?Val?Ala?Tyr?Arg?Tyr?Arg?Arg?Trp?Lys

20??????????????????25??????????????????30Leu?Gly?Asp?Asp?Ile?Asp?Leu?Ile?Val?Arg?Cys?Glu?His?Asp?Gly?Val

35??????????????????40??????????????????45Met?Thr?Gly?Ala?Asn?Gly?Glu?Val?Ser?Phe?Ile?Asn?Ile?Lys?Thr?Leu

50??????????????????55??????????????????60Asn?Glu?Trp?Asp?Ser?Arg?His?Cys?Asn?Gly?Val?Asp?Trp?Arg?Gln?Lys65??????????????????70??????????????????75??????????????????80Leu?Asp?Ser?Gln?Arg?Gly?Ala?Val?Ile?Ala?Thr?Glu?Leu?Lys?Asn?Asn

85??????????????????90??????????????????95Ser?Tyr?Lys?Leu?Ala?Arg?Trp?Thr?Cys?Cys?Ala?Leu?Leu?Ala?Gly?Ser

100?????????????????105?????????????????110Glu?Tyr?Leu?Lys?Leu?Gly?Tyr?Val?Ser?Arg?Tyr?His?Val?Lys?Asp?Ser

115?????????????????120?????????????????125Ser?Arg?His?Val?Ile?Leu?Gly?Thr?Gln?Gln?Phe?Lys?Pro?Asn?Glu?Phe

130?????????????????135?????????????????140Ala?Ser?Gln?Ile?Asn?Leu?Ser?Val?Glu?Asn?Ala145?????????????????150?????????????????155

<210>115

<211>129

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>115Gly?Val?Arg?Trp?Leu?Thr?Arg?Ala?Leu?Val?Ser?Ala?Gly?Asn?Pro?Gly?1???????????????5??????????????????10??????????????????15Ala?Trp?Arg?Gly?Leu?Ser?Thr?Ser?Ala?Ala?Ala?His?Ala?Ala?Ser?Arg

20??????????????????25??????????????????30Ser?Gln?Ala?Ala?Ala?Val?Pro?Val?Glu?Phe?Gln?Glu?His?His?Leu?Ser

35??????????????????40??????????????????45Glu?Val?Gln?Asn?Met?Ala?Ser?Glu?Glu?Lys?Leu?Glu?Gln?Val?Leu?Ser

50??????????????????55??????????????????60Ser?Met?Lys?Glu?Asn?Lys?Val?Ala?Ile?Ile?Gly?Lys?Ile?His?Thr?Pro65??????????????????70??????????????????75??????????????????80Met?Glu?Tyr?Lys?Gly?Glu?Leu?Ala?Ser?Tyr?Asp?Met?Arg?Leu?Arg?Arg

85??????????????????90??????????????????95Lys?Leu?Asp?Leu?Phe?Ala?Asn?Val?Ile?His?Val?Lys?Ser?Leu?Pro?Gly

100?????????????????105?????????????????110Tyr?Met?Thr?Arg?His?Asn?Asn?Leu?Asp?Leu?Val?Ile?Ile?Arg?Glu?Gln

115?????????????????120?????????????????125Thr

<210>116

<211>550

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>116gaattcggca?ccagcctcag?agccccccag?cccggctacc?accccctgcg?gaaaggtacc?????60catctgcatt?cctgcccgtc?gggacctggt?ggacagtcca?gcctccttgg?cctctagcct????120tggctcaccg?ctgcctagag?ccaaggagct?catcctgaat?gaccttcccg?ccagcactcc????180tgcctccaaa?tcctgtgact?cctccccgcc?ccaggacgct?tccaccccca?ggcccagctc????240ggccagtcac?ctctgccagc?ttgctgccaa?gccagcacct?tccacggaca?gcgtcgccct????300gaggagcccc?ctgactctgt?ccagtccctt?caccacgtcc?ttcagcctgg?gctcccacag????360cactctcaac?ggagacctct?ccgtgcccag?ctcctacgtc?agcctccacc?tgtcccccca????420ggtcagcagc?tctgtggtgt?acggacgctc?ccccgtgatg?gcatttgagt?ctcatcccca????480tctccgaggg?tcatccgtct?cttcctccct?acccagcatc?cctgggggaa?agccggccta????540ctccttccac???????????????????????????????????????????????????????????550

<210>117

<211>154

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>117ttctgaggga?aagccgagtg?gagtgggcga?cccggcggcg?gtgacaatga?gttttcttgg?????60aggctttttt?ggtcccattt?gtgagattga?tgttgccctt?aatgatgggg?aaaccaggaa????120aatggcagaa?atgaaaactg?aggatggcaa?agta????????????????????????????????154

<210>118

<211>449

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>118gaattcggca?ccagggcccg?cagcccgagt?gtcgccgcca?tggcttcgcc?gcagctctgc?????60cgcgcgctgg?tgtcggcgca?atgggtggcg?gaggcgctgc?gggccccgcg?cgctgggcag????120cctctgcagc?tgctggscgc?ctcctggtsc?ctgccgaagc?tggggcgcga?cgcgcgscgc????180gagttcgagg?agcgccacat?cccgggcgcc?gctttcttcg?scatcgacca?gtgcagcgac????240cgcacctcgc?cctacgacca?catgctgccc?ggggccgagc?atttcgcgga?gtacgcaggc????300cgcctgggcg?tgggcgcggc?cacccacgtc?gtgatctacg?scgccagcga?ccagggcctc????360tactccgccc?cgcgcgtctg?gtggatgttc?cgcgccttcg?gccaccacgc?cgtgtcactg????420cttgatggcg?gcctccgcca?ctggctgcg??????????????????????????????????????449

<210>119

<211>642

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>119gaattcggca?cgagcagtaa?cccgaccgcc?gctggtcttc?gctggacacc?atgaatcaca?????60ctgtccaaac?cttcttctct?cctgtcaaca?gtggccagcc?ccccaactat?gagatgctca????120aggaggagca?cgaggtggct?gtgctggggg?cgccccacaa?ccctgctccc?ccgacgtcca????180ccgtgatcca?catccgcagc?gagacctccg?tgcccgacca?tgtcgtctgg?tccctgttca????240acaccctctt?catgaacccc?tgctgcctgg?gcttcatagc?attcgcctac?tccgtgaagt????300ctagggacag?gaagatggtt?ggcgacgtga?ccggggccca?ggcctatgcc?tccaccgcca????360agtgcctgaa?catctgggcc?ctgattctgg?gcatcctcat?gaccattctg?ctcatcgtca????420tcccagtgct?gatcttccag?gcctatggat?agatcaggag?gcatcactga?ggccaggagc????480tctgcccatg?acctgtatcc?cacgtactcc?aacttccatt?cctcgccctg?cccccggagc????540cgagtcctgt?atcagccctt?tatcctcaca?cgcttttcta?caatggcatt?caataaagtg????600cacgtgtttc?tggtgaaaaa?aaaaaaaaaa?aaaaaactcg?ag???????????????????????642

<210>120

<211>603

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>120gaattcggca?cgagccacaa?cagccactac?gactgcatcc?actggatcca?cggccacccc?????60gtcctccacc?ccgggaacag?ctccccctcc?caaagtgctg?accagcccgg?ccaccacacc????120catgtccacc?atgtccacaa?tccacacctc?ctctactcca?gagaccaccc?acacctccac????180agtgctgacc?accacagcca?ccatgacaag?ggccaccaat?tccacggcca?caccctcctc????240cactctgggg?acgacccgga?tcctcactga?gctgaccaca?acagccacta?caactgcagc????300cactggatcc?acggccaccc?tgtcctccac?cccagggacc?acctggatcc?tcacagagcc????360gagcactata?gccaccgtga?tggtgcccac?cggttccacg?gccaccgcct?cctccactct????420gggaacagct?cacaccccca?aagtggtgac?caccatggcc?actatgccca?cagccactgc????480ctccacggtt?cccagctcgt?ccaccgtggg?gaccacccgc?acccctgcag?tgctccccag????540cagcctgcca?accttcagcg?tgtccactgt?gtcctcctca?gtcctcacca?ccctgagacc????600cac??????????????????????????????????????????????????????????????????603

<210>121

<211>178

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>121Ser?Glu?Pro?Pro?Ser?Pro?Ala?Thr?Thr?Pro?Cys?Gly?Lys?Val?Pro?Ile?l???????????????5??????????????????l0??????????????????15Cys?Ile?Pro?Ala?Arg?Arg?Asp?Leu?Val?Asp?Ser?Pro?Ala?Ser?Leu?Ala

20??????????????????25??????????????????30Ser?Ser?Leu?Gly?Ser?Pro?Leu?Pro?Arg?Ala?Lys?Glu?Leu?Ile?Leu?Asn

35??????????????????40??????????????????45Asp?Leu?Pro?Ala?Ser?Thr?Pro?Ala?Ser?Lys?Ser?Cys?Asp?Ser?Ser?Pro

50??????????????????55??????????????????60Pro?Gln?Asp?Ala?Ser?Thr?Pro?Arg?Pro?Ser?Ser?Ala?Ser?His?Leu?Cys65??????????????????70??????????????????75??????????????????80Gln?Leu?Ala?Ala?Lys?Pro?Ala?Pro?Ser?Thr?Asp?Ser?Val?Ala?Leu?Arg

85??????????????????90??????????????????95Ser?Pro?Leu?Thr?Leu?Ser?Ser?Pro?Phe?Thr?Thr?Ser?Phe?Ser?Leu?Gly

100?????????????????105?????????????????110Ser?His?Ser?Thr?Leu?Asn?Gly?Asp?Leu?Ser?Val?Pro?Ser?Ser?Tyr?Val

115?????????????????120?????????????????125Ser?Leu?His?Leu?Ser?Pro?Gln?Val?Ser?Ser?Ser?Val?Val?Tyr?Gly?Arg

130?????????????????135?????????????????140Ser?Pro?Val?Met?Ala?Phe?Glu?Ser?His?Pro?His?Leu?Arg?Gly?Ser?Ser145?????????????????150?????????????????155?????????????????160Val?Ser?Ser?Ser?Leu?Pro?Ser?Ile?Pro?Gly?Gly?Lys?Pro?Ala?Tyr?Ser

165?????????????????170?????????????????175Phe?His

<210>122

<211>36

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>122Met?Ser?Phe?Leu?Gly?Gly?Phe?Phe?Gly?Pro?Ile?Cys?Glu?Ile?Asp?Val?1???????????????5??????????????????10??????????????????15Ala?Leu?Asn?Asp?Gly?Glu?Thr?Arg?Lys?Met?Ala?Glu?Met?Lys?Thr?Glu

20??????????????????25??????????????????30Asp?Gly?Lys?Val

35

<210>123

<211>136

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>123Met?Ala?Ser?Pro?Gln?Leu?Cys?Arg?Ala?Leu?Val?Ser?Ala?Gln?Trp?Val?1???????????????5??????????????????10??????????????????15Ala?Glu?Ala?Leu?Arg?Ala?Pro?Arg?Ala?Gly?Gln?Pro?Leu?Gln?Leu?Leu

20??????????????????25??????????????????30Asp?Ala?Ser?Trp?Tyr?Leu?Pro?Lys?Leu?Gly?Arg?Asp?Ala?Arg?Arg?Glu

35??????????????????40??????????????????45Phe?Glu?Glu?Arg?His?Ile?Pro?Gly?Ala?Ala?Phe?Phe?Asp?Ile?Asp?Gln

50??????????????????55??????????????????60Cys?Ser?Asp?Arg?Thr?Ser?Pro?Tyr?Asp?His?Met?Leu?Pro?Gly?Ala?Glu65??????????????????70??????????????????75??????????????????80His?Phe?Ala?Glu?Tyr?Ala?Gly?Arg?Leu?Gly?Val?Gly?Ala?Ala?Thr?His

85??????????????????90??????????????????95Val?Val?Ile?Tyr?Asp?Ala?Ser?Asp?Gln?Gly?Leu?Tyr?Ser?Ala?Pro?Arg

100?????????????????105?????????????????110Val?Trp?Trp?Met?Phe?Arg?Ala?Phe?Gly?His?His?Ala?Val?Ser?Leu?Leu

115?????????????????120?????????????????125Asp?Gly?Gly?Leu?Arg?His?Trp?Leu

130?????????????????135

<210>124

<211>133

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>124Met?Asn?His?Thr?Val?Gln?Thr?Phe?Phe?Ser?Pro?Val?Asn?Ser?Gly?Gln?1???????????????5??????????????????10??????????????????15Pro?Pro?Asn?Tyr?Glu?Met?Leu?Lys?Glu?Glu?His?Glu?Val?Ala?Val?Leu

20??????????????????25??????????????????30Gly?Ala?Pro?His?Asn?Pro?Ala?Pro?Pro?Thr?Ser?Thr?Val?Ile?His?Ile

35??????????????????40??????????????????45Arg?Ser?Glu?Thr?Ser?Val?Pro?Asp?His?Val?Val?Trp?Ser?Leu?Phe?Asn

50??????????????????55??????????????????60Thr?Leu?Phe?Met?Asn?Pro?Cys?Cys?Leu?Gly?Phe?Ile?Ala?Phe?Ala?Tyr65??????????????????70??????????????????75??????????????????80Ser?Val?Lys?Ser?Arg?Asp?Arg?Lys?Met?Val?Gly?Asp?Val?Thr?Gly?Ala

85??????????????????90??????????????????95Gln?Ala?Tyr?Ala?Ser?Thr?Ala?Lys?Cys?Leu?Asn?Ile?Trp?Ala?Leu?Ile

100?????????????????105?????????????????110Leu?Gly?Ile?Leu?Met?Thr?Ile?Leu?Leu?Ile?Val?Ile?Pro?Val?Leu?Ile

115?????????????????120?????????????????125Phe?Gln?Ala?Tyr?Gly

130

<210>125

<211>195

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>125Thr?Thr?Ala?Thr?Thr?Thr?Ala?Ser?Thr?Gly?Ser?Thr?Ala?Thr?Pro?Ser?1???????????????5??????????????????10??????????????????15Ser?Thr?Pro?Gly?Thr?Ala?Pro?Pro?Pro?Lys?Val?Leu?Thr?Ser?Pro?Ala

20??????????????????25??????????????????30Thr?Thr?Pro?Met?Ser?Thr?Met?Ser?Thr?Ile?His?Thr?Ser?Ser?Thr?Pro

35??????????????????40??????????????????45Glu?Thr?Thr?His?Thr?Ser?Thr?Val?Leu?Thr?Thr?Thr?Ala?Thr?Met?Thr

50??????????????????55??????????????????60Arg?Ala?Thr?Asn?Ser?Thr?Ala?Thr?Pro?Ser?Ser?Thr?Leu?Gly?Thr?Thr65??????????????????70??????????????????75??????????????????80Arg?Ile?Leu?Thr?Glu?Leu?Thr?Thr?Thr?Ala?Thr?Thr?Thr?Ala?Ala?Thr

85??????????????????90??????????????????95Gly?Ser?Thr?Ala?Thr?Leu?Ser?Ser?Thr?Pro?Gly?Thr?Thr?Trp?Ile?Leu

100?????????????????105?????????????????110Thr?Glu?Pro?Ser?Thr?Ile?Ala?Thr?Val?Met?Val?Pro?Thr?Gly?Ser?Thr

115?????????????????120?????????????????125Ala?Thr?Ala?Ser?Ser?Thr?Leu?Gly?Thr?Ala?His?Thr?Pro?Lys?Val?Val

130?????????????????135?????????????????140Thr?Thr?Met?Ala?Thr?Met?Pro?Thr?Ala?Thr?Ala?Ser?Thr?Val?Pro?Ser145?????????????????150?????????????????155?????????????????160Ser?Ser?Thr?Val?Gly?Thr?Thr?Arg?Thr?Pro?Ala?Val?Leu?Pro?Ser?Ser

165?????????????????170?????????????????175Leu?Pro?Thr?Phe?Ser?Val?Ser?Thr?Val?Ser?Ser?Ser?Val?Leu?Thr?Thr

180?????????????????185?????????????????190Leu?Arg?Pro

195

<210>126

<211>509

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>126gaattcggca?cgagccaagt?accccctgag?gaatctgcag?cctgcatctg?agtacaccgt?????60atccctcgtg?gccataaagg?gcaaccaaga?gagccccaaa?gccactggag?tctttaccac????120actgcagcct?gggagctcta?ttccacctta?caacaccgag?gtgactgaga?ccaccattgt????180gatcacatgg?acgcctgctc?caagaattgg?ttttaagctg?ggtgtacgac?caagccaggg????240aggagaggca?ccacgagaag?tgacttcaga?ctcaggaagc?atcgttgtgt?ccggcttgac????300tccaggagta?gaatacgtct?acaccatcca?agtcctgaga?gatggacagg?aaagagatgc????360gccaattgta?aacaaagtgg?tgacaccatt?gtctccacca?acaaacttgc?atctggaggc????420aaaccctgac?actggagtgc?tcacagtctc?ctggagagga?gcaccacccc?agacattact????480gggtatagaa?ttaccacaac?ccctacaaa??????????????????????????????????????509

<210>127

<211>500

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>127gaattcggca?cgagccactg?atgtccgggg?agtcagccag?gagcttgggg?aagggaagcg?????60cgcccccggg?gccggtcccg?gagggctcga?tccgcatcta?cagcatgagg?ttctgcccgt????120ttgctgagag?gacgcgtcta?gtcctgaagg?ccaagggaat?caggcatgaa?gtcatcaata????180tcaacctgaa?aaataagcct?gagtggttct?ttaagaaaaa?tccctttggt?ctggtgccag????240ttctggaaaa?cagtcagggt?cagctgatct?acgagtctgc?catcacctgt?gagtacctgg????300atgaagcata?cccagggaag?aagctgttgc?cggatgaccc?ctatgagaaa?gcttgccaga????360agatgatctt?agagttgttt?tctaaggtgc?catccttggt?aggaagcttt?attagaagcc????420aaaataaaga?agactatgct?ggcctaaaag?aagaatttcg?taaagaattt?accaagctag????480aggaggttct?gactaataag????????????????????????????????????????????????500

<210>128

<211>500

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>128agctttcctc?tgctgccgct?cggtcacgct?tgtgcccgaa?ggaggaaaca?gtgacagacc?????60tggagactgc?agttctctat?ccttcacaca?gctctttcac?catgcctgga?tcacttcctt????120tgaatgcaga?agcttgctgg?ccaaaagatg?tgggaattgt?tgcccttgag?atctattttc????180cttctcaata?tgttgatcaa?gcagagttgg?aaaaatatga?tggtgtagat?gctggaaagt????240ataccattgg?cttgggccag?gccaagatgg?gcttctgcac?agatagagaa?gatattaact????300ctctttgcat?gactgtggtt?cagaatctta?tggagagaaa?taacctttcc?tatgattgca????360ttgggcggct?ggaagttgga?acagagacaa?tcatcgacaa?atcaaagtct?gtgaagacta????420atttgatgca?gctgtttgaa?gagtctggga?atacagatat?agaaggaatc?gacacaacta????480atgcatgcta?tggaggcaca????????????????????????????????????????????????500

<210>129

<211>497

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>129gaattcggca?cgagcagagg?tctccagagc?cttctctctc?ctgtgcaaaa?tggcaactct?????60taaggaaaaa?ctcattgcac?cagttgcgga?agaagaggca?acagttccaa?acaataagat????120cactgtagtg?ggtgttggac?aagttggtat?ggcgtgtgct?atcagcattc?tgggaaagtc????180tctggctgat?gaacttgctc?ttgtggatgt?tttggaagat?aagcttaaag?gagaaatgat????240ggatctgcag?catgggagct?tatttcttca?gacacctaaa?attgtggcag?ataaagatta????300ttctgtgacc?gccaattcta?agattgtagt?ggtaactgca?ggagtccgtc?agcaagaagg????360ggagagtcgg?ctcaatctgg?tgcagagaaa?tgttaatgtc?ttcaaattca?ttattcctca????420gatcgtcaag?tacagtcctg?attgcatcat?aattgtggtt?tccaacccag?tggacattct????480tacgtatgtt?acctgga???????????????????????????????????????????????????497

<210>130

<211>383

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>130gaattcggca?cgagggccgc?ggctgccgac?tgggtcccct?gccgctgtcg?ccaccatggc?????60tccgcaccgc?cccgcgcccg?cgctgctttg?cgcgctgtcc?ctggcgctgt?gcgcgctgtc????120gctgcccgtc?cgcgcggcca?ctgcgtcgcg?gggggcgtcc?caggcggggg?cgccccaggg????180gcgggtgccc?gaggcgcggc?ccaacagcat?ggtggtggaa?caccccgagt?tcctcaaggc????240agggaaggag?cctggcctgc?agatctggcg?tgtggagaaa?gttcgatctg?gtggcccgtg????300cccaccaacc?tttatggaga?cttcttcacg?ggcgacgcct?acgtcatcct?gaagacagtg????360cagcttaaga?acggaaaatc?ttg????????????????????????????????????????????383

<210>131

<211>509

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>131gaattcggca?cgagagtcag?ccgcatcttc?ttttgcgtcg?ccagccgagc?cacatcgctc?????60agacaccatg?gggaaggtga?aggtcggagt?caacggattt?ggtcgtattg?ggcgcctggt????120caccagggct?gcttttaact?ctggtaaagt?ggatattgtt?gccatcaatg?accccttcat????180tgacctcaac?tacatggttt?acatgttcca?atatgattcc?acccatggca?aattccatgg????240caccgtcaag?gctgagaacg?ggaagcttgt?catcaatgga?aatcccatca?ccatcttcca????300ggagcgagat?ccctccaaaa?tcaagtgggg?cgatgctggc?gctgagtacg?tcgtggagtc????360cactggccgt?cttcaccacc?atggagaagg?ctggggctca?tttgcagggg?ggagccaaaa????420gggtcatcat?ctctgccccc?tctgctgacg?cccccatgtt?cgtcatgggt?gtgaaccatg????480agaagtatga?caacagcctc?aagatcatc??????????????????????????????????????509

<210>132

<211>357

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>132gaattcggca?cgagtaagaa?gaagccccta?gaccacagct?ccacaccatg?gactggacct?????60ggaggatcct?cttcttggtg?gcagcagcaa?caggtgccca?ctcccaggtg?caactggtgc????120aatctgggtc?tgagttgaag?aagcctgggg?cctcagtgaa?ggtttcctgc?aaggcttctg????180gacacatctt?cagtatctat?ggtttgaatt?gggtgcgaca?ggcccctggt?caaggccttg????240agtggatggg?atggatcaaa?gtcgacactg?cgaacccaac?gtatgcccag?ggcttcacag????300gacgatttgt?cttctccctg?gacacctctg?tcagcacggc?atatctgcag?atcagca???????357

<210>133

<211>468

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>133gaattcggca?cgaggcgccc?cgaaccgtcc?tcctgctgct?ctcggcggcc?ctggccctga?????60ccgagacctg?ggccggctcc?cactccatga?ggtatttcga?caccgccatg?tcccggcccg????120gccgcgggga?gccccgcttc?atctcagtgg?gctacgtgga?cgacacgcag?ttcgtgaggt????180tcgacagcga?cgccgcgagt?ccgagagagg?agccgcgggc?gccgtggata?gagcaggagg????240ggccggagta?ttgggaccgg?aacacacaga?tcttcaagac?caacacacag?actgaccgag????300agagcctgcg?gaacctgcgc?ggctactaca?accagagcga?ggccgggtct?cacaccctcc????360agagcatgta?cggctgcgac?gtggggccgg?acgggcgcct?cctccgcggg?cataaccagt????420acgcctacga?cggcaaggat?tacatcgccc?tgaacgagga?cctgcgct?????????????????468

<210>134

<211>214

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>134gaattcggca?cgagctgcgt?cctgctgagc?tctgttctct?ccagcacctc?ccaacccact?????60agtgcctggt?tctcttgctc?caccaggaac?aagccaccat?gtctcgccag?tcaagtgtgt????120ccttccggag?cgggggcagt?cgtagcttca?gcaccgcctc?tgccatcacc?ccgtctgtct????180cccgcaccag?cttcacctcc?gtgtcccggt?ccgg????????????????????????????????214

<210>135

<211>355

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>135gaattcggca?cgaggtgaac?aggacccgtc?gccatgggcc?gtgtgatccg?tggacagagg?????60aagggcgccg?ggtctgtgtt?ccgcgcgcac?gtgaagcacc?gtaaaggcgc?tgcgcgcctg????120cgcgccgtgg?atttcgctga?gcggcacggc?tacatcaagg?gcatcgtcaa?ggacatcatc????180cacgacccgg?gccgcggcgc?gcccctcgcc?aaggtggtct?tccgggatcc?gtatcggttt????240aagaagcgga?cggagctgtt?cattgccgcc?gagggcattc?acacgggcca?gtttgtgtat????300tgcggcaaga?aggcccagct?caacattggc?aatgtgctcc?ctgtgggcac?catgc?????????355

<210>136

<211>242

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>136gaattcggca?cgagccagct?cctaaccgcg?agtgatccgc?cagcctccgc?ctcccgaggt?????60gcccggattg?cagacggagt?ctccttcact?cagtgctcaa?tggtgcccag?gctggagtgc????120agtggtgtga?tctcggctcg?ctacaacatc?cacctcccag?cagcctgcct?tggcctccca????180aagtgccgag?attgcagctc?tctgcccggc?cgccacccct?gtctgggaag?tgaggatgct????240gt???????????????????????????????????????????????????????????????????242

<210>137

<211>424

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>137gaattcggca?cgagcccaga?tcccgaggtc?cgacagcgcc?cggcccagat?ccccacgcct?????60gccaggagca?agccgagagc?cagccggccg?gcgcactccg?actccgagca?gtctctgtcc????120ttcgacccga?gccccgcgcc?ctttccggga?cccctgcccc?gcgggcagcg?ctgccaacct????180gccggccatg?gagaccccgt?cccagcggcg?cgccacccgc?agcggggcgc?aggccagctc????240cactccgctg?tcgcccaccc?gcatcacccg?gctgcaggag?aaggaggacc?tgcaggagct????300caatgatcgc?ttggcggtct?acatcgaccg?tgtgcgctcg?ctggaaacgg?agaacgcagg????360gctgcgcctt?cgcatcaccg?agtctgaaga?ggtggtcagc?cgcgaggtgt?ccggcatcaa????420ggcc?????????????????????????????????????????????????????????????????424

<210>138

<211>448

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>138gaattcggca?cgagcctgtg?ttccaggagc?cgaatcagaa?atgtcatcct?caggcacgcc?????60agacttacct?gtcctactca?ccgatttgaa?gattcaatat?actaagatct?tcataaacaa????120tgaatggcat?gattcagtga?gtggcaagaa?atttcctgtc?tttaatcctg?caactgagga????180ggagctctgc?caggtagaag?aaggagataa?ggaggatgtt?gacaaggcag?tgaaggccgc????240aagacaggct?tttcagattg?gatccccgtg?gcgtactatg?gatgcttccg?agagggggcg????300actattatac?aagttggctg?atttaatcga?aagagatcgt?ctgctgctgg?ccgacaatgg????360agtcaatgaa?tggtggaaaa?ctctattcca?atgcatatct?gaatgattta?gcaggctgca????420tcaaaacatt?gcgctactgt?gcaggttg???????????????????????????????????????448

<210>139

<211>510

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>139gaattcggca?cgaggttccg?tgcagctcac?ggagaagcga?atggacaaag?tcggcaagta?????60ccccaaggag?ctgcgcaagt?gctgcgagga?cggcatgcgg?gagaacccca?tgaggttctc????120gtgccagcgc?cggacccgtt?tcatctccct?ggcgaggcgt?gcaagaaggt?cttcctggac????180tgctgcaact?acatcacaga?gctgcggcgg?cagcacgcgc?gggccagcca?cctggcctgc????240caggagtaac?ctggatgagg?acatcattgc?agaagagaac?atcgtttccc?gaagtgagtt????300cccagagagc?tggctgtgga?acgttgagga?cttgaaagag?ccaccgaaaa?atggaatctc????360tacgaagctc?atgaatatat?ttttgaaaga?ctccatcacc?acgtgggaga?ttctggctgt????420gagcatgtcg?gacaagaaag?ggatctgtgt?ggcagacccc?ttcgaggtca?cagtaatgca????480ggacttcttc?atcgacctgc?ggctacccta?????????????????????????????????????510

<210>140

<211>360

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>140gaattcggca?cgagcggtaa?ctaccccggc?tgcgcacagc?tcggcgctcc?ttcccgctcc?????60ctcacacacc?ggcctcagcc?cgcaccggca?gtagaagatg?gtgaaagaaa?caacttacta????120cgatgttttg?ggggtcaaac?ccaatgctac?tcaggaagaa?ttgaaaaagg?cttataggaa????180actggctttg?aagtaccatc?ctgataagaa?cccaaatgaa?ggagagaagt?ttaaacagat????240ttctcaagct?tacgaagttc?tctctgatgc?aaagaaaagg?gaattatatg?acaaaggagg????300agaacaggca?attaaagagg?gtggagcagg?tggcggtttt?ggctccccca?tggacatctt????360

<210>141

<211>483

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>141gaattcggca?cgagagcaga?ggctgatctt?tgctggaaaa?cagctggaag?atgggctgca?????60ccctgtctga?ctacaacatc?cagaaagagt?ccaccctgca?cctggtgctc?cgtctcagag????120gtgggatgca?aatcttcgtg?aagacactca?ctggcaagac?catcaccctt?gaggtggagc????180ccagtgacac?catcgagaac?gtcaaagcaa?agatccagga?caaggaaggc?attcctcctg????240accagcagag?gttgatcttt?gccggaaagc?agctggaaga?tgggcgcacc?ctgtctgact????300acaacatcca?gaaagagtct?accctgcacc?tggtgctccg?tctcagaggt?gggatgcaga????360tcttcgtgaa?gaccctgact?ggtaagacca?tcaccctcga?ggtggagccc?agtgacacca????420tcgagaatgt?caaggcaaag?atccaagata?aggaaggcat?tcctcctgat?cagcagaggt????480tga??????????????????????????????????????????????????????????????????483

<210>142

<211>500

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>142gaattcggca?cgaggcggcg?acgaccgccg?ggagcgtgtg?cagcggcggc?ggcggaagtg?????60gccggcgagc?ccggtccccg?ccggcaccat?gcttcccttg?tcactgctga?agacggctca????120gaatcacccc?atgttggtgg?agctgaaaaa?tggggagacg?tacaatggac?acctggtgag????180ctgcgacaac?tggatgaaca?ttaacctgcg?agaagtcatc?tgcacgtcca?gggacgggga????240caagttctgg?cggatgcccg?agtgctacat?ccgcggcagc?accatcaagt?acctgcgcat????300ccccgacgag?atcatcgaca?tggtcaagga?ggaggtggtg?gccaagggcc?gcggccgcgg????360aggcctgcag?cagcagaagc?agcagaaagg?ccgcggcatg?ggcggcgctg?gccgaggtgt????420gtttggtggc?cggggccgag?gtgggatccc?gggcacaggc?agaagccagc?cagagaagaa????480gcctggcaga?caggcgggca????????????????????????????????????????????????500

<210>143

<211>400

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>143gaattcggca?cgagctcgga?tgtcagcagg?cgtcccaacc?cagcaggaac?tggctcaatt?????60ctcagaagaa?agcgatcggc?cccgaggcag?gaaggccggc?tccggtgcag?ggcgcgccgc????120ctgcgggctg?cttcgggcca?gggtcgaccc?gagggccagc?gcaagcagcg?gcaacaggag????180cgccaggagg?acatgaggct?ctgcctgcag?tcagcaactt?ggaatattca?gacttcagac????240cagcatcaca?gattataacc?ctccgtaaat?catctgcatc?ccagctccca?tcaaaagcca????300gcctgaagga?cccatggaca?cgtgactcca?gtgttctcaa?caacatctta?gatcaagttg????360gtttgcacaa?catttgcatc?tacttgggac?aaagcaagaa??????????????????????????400

<210>144

<211>243

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>144gaattcggca?cgagccagct?cctaaccgcg?agtgatccgc?cagcctccgc?ctcccgaggt?????60gcccggattg?cagacggagt?ctccttcact?cagtgctcaa?tggtgcccag?gctggagtgc????120agtggtgtga?tctcggctcg?ctacaacatc?cacctcccag?cagcctgcct?tggcctccca????180aagtgccgag?attgcagcct?ctgcccggcc?gtcaccccgt?ctgggaagtg?aggagcgttt????240ctg??????????????????????????????????????????????????????????????????243

<210>145

<211>450

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>145gaattcggca?cgaggacagc?aggaccgtgg?aggccgcggc?aggggtggca?gtggtggcgg?????60cggcggcggc?ggcggtggtg?gttacaaccg?cagcagtggt?ggctatgaac?ccagaggtcg????120tggaggtggc?cgtggaggca?gaggtggcat?gggcggaagt?gaccgtggtg?gcttcaataa????180atttggtggc?cctcgggacc?aaggatcacg?tcatgactcc?gaacaggata?attcagacaa????240caacaccatc?tttgtgcaag?gcctgggtga?gaatgttaca?attgagtctg?tggctgatta????300cttcaagcag?attggtatta?ttaagacaaa?caagaaaacg?ggacagccca?tgattaattt????360gtacacagac?agggaaactg?gcaagctgaa?gggagaggca?acggtctctt?ttgatgaccc????420accttcagct?aaagcagcct?attgactggt?????????????????????????????????????450

<210>146

<211>451

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>146gaattcggca?cgagccatcg?agtccctgcc?tttcgacttg?cagagaaatg?tctcgctgat?????60gcgggagatc?gacgcgaaat?accaagagat?cctgaaggag?ctagacgagt?gctacgagcg????120cttcagtcgc?gagacagacg?gggcgcagaa?gcggcggatg?ctgcactgtg?tgcagcgcgc????180gctgatccgc?accaggagct?gggcgacgag?aagatccaga?tcgtgagcca?gatggtggag????240ctggtggaga?accgcacgcg?gcaggtggac?agccacgtgg?agctgttcga?ggcgcagcag????300gagctgggcg?acacagcggg?caacagcggc?aaggctggcg?cggacaggcc?caaaggcgag????360gcggcagcgc?aggctgacaa?gcccaacagc?aagcgctcac?ggcggcagcg?caacaacgag????420aaccgtgaga?acgcgtccag?caaccacgac?c???????????????????????????????????451

<210>147

<211>400

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>147gaattcggca?cgagctcgga?tgtcagcagg?cgtcccaacc?cagcaggaac?tggctcaatt?????60ctcagaagaa?agcgatcggc?cccgaggcag?gaaggccggc?tccggtgcag?ggcgcgccgc????120ctgcgggctg?cttcgggcca?gggtcgaccc?gagggccagc?gcaagcagcg?gcaacaggag????180cgccaggagg?acatgaggct?ctgcctgcag?tcagcaactt?ggaatattca?gacttcagac????240cagcatcaca?gattataacc?ctccgtaaat?catctgcatc?ccagctccca?tcaaaagcca????300gcctgaagga?cccatggaca?cgtgactcca?gtgttctcaa?caacatctta?gatcaagttg????360gtttgcacaa?catttgcatc?tacttgggac?aaagcaagaa??????????????????????????400

<210>148

<211>503

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>148aaaagaattc?ggcacgagcg?gcgccgctca?tccccctctc?ccagcagatt?cccactggaa?????60attcgttgta?tgaatcttat?tacaagcagg?tcgatccggc?atacacaggg?agggtggggg????120cgagtgaagc?tgcgcttttt?ctaaagaagt?ctggcctctc?ggacattatc?cttgggaaga????180tatgggactt?ggccgatcca?gaaggtaaag?ggttcttgga?caaacagggt?ttctatgttg????240cactgagact?ggtggcctgt?gcacagagtg?gccatgaagt?taccttgagc?aatctgaatt????300tgagcatgcc?accgcctaaa?tttcacgaca?ccagcagccc?tctgatggtc?acaccgccct????360ctgcagaggc?ccactgggct?gtgagggtgg?aagaaaaggc?caaatttgat?gggatttttg????420aaagcctctt?gcccatcaat?ggtttgctct?ctggagacaa?agtcaagcca?gtcctcatga????480actcaaagct?gcctcttgat?gtc????????????????????????????????????????????503

<210>149

<211>1061

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>149gaattcggca?cgaggccttt?tccagcaacc?ccaaggtcca?ggtggaggcc?atcgaagggg??????60gagccctgca?gaagctgctg?gtcatcctgg?ccacggagca?gccgctcact?gcaaagaaga?????120aggtcctgtt?tgcactgtgc?tccctgctgc?gccacttccc?ctatgcccag?cggcagttcc?????180tgaagctcgg?ggggctgcag?gtcctgagga?ccctggtgca?ggagaagggc?acggaggtgc?????240tcgccgtgcg?cgtggtcaca?ctgctctacg?acctggtcac?ggagaagatg?ttcgccgagg?????300aggaggctga?gctgacccag?gagatgtccc?cagagaagct?gcagcagtat?cgccaggtac?????360acctcctgcc?aggcctgtgg?gaacagggct?ggtgcgagat?cacggcccac?ctcctggcgc?????420tgcccgagca?tgatgcccgt?gagaaggtgc?tgcagacact?gggcgtcctc?ctgaccacct?????480gccgggaccg?ctaccgtcag?gacccccagc?tcggcaggac?actggccagc?ctgcaggctg?????540agtaccaggt?gctggccagc?ctggagctgc?aggatggtga?ggacgagggc?tacttccagg?????600agctgctggg?ctctgtcaac?agcttgctga?aggagctgag?atgaggcccc?acaccagtac?????660tggactggga?tgccgctagt?gaggctgagg?ggtgccagcg?tgggtgggct?tctcaggcag?????720gaggacatct?tggcagtgct?ggcttggcca?ttaaatggaa?acctgaaggc?catcctcttt?????780ctgctgtgtg?tctgtgtaga?ctgggcacag?ccctgtggcc?ggggggtcag?gtgagtggtt?????840gggtgatggg?ctctgctgac?gtgcagggct?cagcccaggg?catccaggaa?caggctccag?????900ggcaggaacc?tgggcccagg?agttgcaagt?ctctgcttct?taccaagcag?cagctctgta?????960ccttgggaag?tcgcttaatt?gctctgagct?tgtttcctca?tctgtcagga?gtgccattaa????1020aggagaaaaa?tcacgtaaaa?aaaaaaaaaa?aaaaactcga?g????????????????????????1061

<210>150

<211>781

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>150gaattcggca?cgagaaatgg?cggcaggggt?cgaagcggca?gccgaagtgg?cggcgacaga?????60acccaaaatg?gaggaagaga?gcggcgcgcc?ctgcgtgccg?agcggcaacg?gagctccggg????120cccgaagggt?gaagaacgac?ctactcagaa?tgagaagagg?aaggagaaaa?acataaaaag????180aggaggcaat?cgctttgagc?catattccaa?cccaactaaa?agatacagag?ccttcattac????240aaatatacct?tttgatgtga?aatggcagtc?acttaaagac?ctggttaaag?aaaaagttgg????300tgaggtaaca?tacgtggagc?tcttaatgga?cgctgaagga?aagtcaaggg?gatgtgctgt????360tgttgaattc?aagatggagg?agagcatgaa?aaaagctgct?gaagttctaa?acaagcatag????420tctgagtgga?aggccactga?aagtcaagga?agatcctgat?ggtgaacatg?caaggagagc????480aatgcaaaag?gctggaagac?ttggaagcac?agtatttgta?gcaaatctgg?attataaagt????540tggctggaag?aaactgaagg?aagtatttag?tatggctggt?gtggtggtcc?gagcagacat????600tctggaagat?aaagatggga?aaagtcgtgg?aataggcatt?gtgacttttg?aacagtccat????660tgaagctgtg?caagcaatat?ctatgtttaa?tggccagttg?ctgtttgata?gaccgatgca????720cgtcaagatg?gatgagaggg?ctttaccaaa?gggagacttt?tttcctcctg?aacgccacag????780c????????????????????????????????????????????????????????????????????781

<210>151

<211>3275

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>151cttaagtgga?tcctgcatca?ggagggagca?gacaccggag?aaagaaaaac?aagttgtgct??????60gtttgaggaa?gcaagttgga?cctgcactcc?agcctgtgga?gatgaaccta?ggactgtgat?????120tctgctatcc?agtatgttgg?ctgaccacag?gctcaaactg?gaggattata?aggatcgcct?????180gaaaagtgga?gagcatctta?atccagacca?gttggaagct?gtagagaaat?atgaagaagt?????240gctacataat?ttggaatttg?ccaaggagct?tcaaaaaacc?ttttctgggt?tgagcctaga?????300tctactaaaa?gcgcaaaaga?aggcccagag?aagggagcac?atgctaaaac?ttgaggctga?????360gaagaaaaag?cttcgaacta?tacttcaagt?tcagtatgta?ttgcagaact?tgacacagga?????420gcacgtacaa?aaagacttca?aagggggttt?gaatggtgca?gtgtatttgc?cttcaaaaga?????480acttgactac?ctcattaagt?tttcaaaact?gacctgccct?gaaagaaatg?aaagtctgag?????540acaaacactt?gaaggatcta?ctgtctaaat?tgctgaactc?aggctatttt?gaaagtatcc?????600cagttcccaa?aaatgccaag?gaaaaggaag?taccactgga?ggaagaaatg?ctaatacaat?????660cagagaaaaa?aacacaatta?tcgaagactg?aatctgtcaa?agagtcagag?tctctaatgg?????720aatttgccca?gccagagata?caaccacaag?agtttcttaa?cagacgctat?atgacagaag?????780tagattattc?aaacaaacaa?ggcgaagagc?aaccttggga?agcagattat?gctagaaaac?????840caaatctccc?aaaacgttgg?gatatgctta?ctgaaccaga?tggtcaagag?aagaaacagg?????900agtcctttaa?gtcctgggag?gcttctggta?agcaccagga?ggtatccaag?cctgcagttt?????960ccttagaaca?gaggaaacaa?gacacctcaa?aactcaggtc?tactctgccg?gaagagcaga????1020agaagcagga?gatctccaaa?tccaagccat?ctcctagcca?gtggaagcaa?gatacaccta????1080aatccaaagc?agggtatgtt?caagaggaac?aaaagaaaca?ggagacacca?aagctgtggc????1140cagttcagct?gcagaaagaa?caagatccaa?agaagcaaac?tccaaagtct?tggacacctt????1200ccatgcagag?cgaacagaac?accaccaagt?catggaccac?tcccatgtgt?gaagaacagg????1260attcaaaaca?gccagagact?ccaaaatcct?gggaaaacaa?tgttgagagt?caaaaacact????1320ctttaacatc?acagtcacag?atttctccaa?agtcctgggg?agtagctaca?gcaagcctca????1380taccaaatga?ccagctgctg?cccaggaagt?tgaacacaga?acccaaagat?gtgcctaagc????1440ctgtgcatca?gcctgtaggt?tcttcctcta?cccttccgaa?ggatccagta?ttgaggaaag????1500aaaaactgca?ggatctgatg?actcagattc?aaggaacttg?taactttatg?caagagtctg????1560ttcttgactt?tgacaaacct?tcaagtgcaa?ttccaacgtc?acaaccgcct?tcagctactc????1620caggtagccc?cgtagcatct?aaagaacaaa?atctgtccag?tcaaagtgat?tttcttcaag????1680agccgttaca?ggtatttaac?gttaatgcac?ctctgcctcc?acgaaaagaa?caagaaataa????1740aagaatcccc?ttattcacct?ggctacaatc?aaagttttac?cacagcaagt?acacaaacac????1800caccccagtg?ccaactgcca?tctatacatg?tagaacaaac?tgtccattct?caagagactg????1860cagcaaatta?tcatcctgat?ggaactattc?aagtaagcaa?tggtagcctt?gccttttacc????1920cagcacagac?gaatgtgttt?cccagaccta?ctcagccatt?tgtcaatagc?cggggatctg????1980ttagaggatg?tactcgtggt?gggagattaa?taaccaattc?ctatcggtcc?cctggtggtt????2040ataaaggttt?tgatacttat?agaggactcc?cttcaatttc?caatggaaat?tatagccagc????2100tgcagttcca?agctagagag?tattctggag?caccttattc?ccaaagggat?aatttccagc????2160agtgttataa?gcgaggaggg?acatctggtg?gtccacgagc?aaattcgaga?gcagggtgga????2220gtgattcttc?tcaggtgagc?agcccagaaa?gagacaacga?aacctttaac?agtggtgact????2280ctggacaagg?agactcccgt?agcatgaccc?ctgtggatgt?gccagtgaca?aatccagcag????2340ccaccatact?gccagtacac?gtctaccctc?tgcctcagca?gatgcgagtt?gccttctcag????2400cagccagaac?ctctaatctg?gcccctggaa?ctttagacca?acctattgtg?tttgatcttc????2460ttctgaacaa?cttaggagaa?acttttgatc?ttcagcttgg?tagatttaat?tgcccagtga????2520atggcactta?cgttttcatt?tttcacatgc?taaagctggc?agtgaatgtg?ccactgtatg????2580tcaacctcat?gaagaatgaa?gaggtcttgg?tatcagccta?tgccaatgat?ggtgctccag????2640accatgaaac?tgctagcaat?catgcaattc?ttcagctctt?ccagggagac?cagatatggt????2700tacgtctgca?caggggagca?atttatggaa?gtagctggaa?atattctacg?ttttcaggct????2760atcttcttta?tcaagattga?aagtcagtac?agtattgaca?ataaaaggat?ggtgttctaa????2820ttagtgggat?tgaaggaaaa?gtagtctttg?ccctcatgac?tgattggttt?aggaaaatgt????2880ttttgttcct?agagggagga?ggtccttact?tttttgtttt?ccttcctgag?gtgaaaaatc????2940aagctgaatg?acaattagca?ctaatctggc?actttataaa?ttgtgatgta?gcctcgctag????3000tcaagctgtg?aatgtatatt?gtttgcactt?aatccttaac?tgtattaacg?ttcagcttac????3060taaactgact?gcctcaagtc?caggcaagtt?acaatgcctt?gttgtgcctc?aataaaaaag????3120ttacatgcaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa????3180aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa????3240aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaac?tcgag???????????????????????????????3275

<210>152

<211>2179

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>152gaattcggca?ccaggcacta?ttaaatgtga?ggcagcctcc?atctactaca?acatttgtgc??????60tgaatcaaat?aaatcatctt?ccacccttgg?gatctacaat?tgtaatgact?aaaacaccac?????120ctgtaacaac?caacaggcaa?accatcactt?taactaagtt?tatccagact?actgcaagca?????180cacgcccgtc?agtctcagca?ccaacagtac?gaaatgccat?gacctctgca?ccttcaaaag?????240accaagttca?gcttaaagat?ctactgaaaa?ataatagtct?taatgaactg?atgaaactaa?????300agccacctgc?taatattgct?cagccagtag?caacagcagc?tactgatgta?agcaatggta?????360cagtaaagaa?agagtcttct?aataaagaag?gagctagaat?gtggataaac?gacatgaaga?????420tgaggagttt?ttccccaacc?atgaaggttc?ctgttgtaaa?agaagatgat?gaaccagagg?????480aagaagatga?agaagaaatg?ggtcatgcag?aaacctatgc?agaatacatg?ccaataaaat?????540taaaaattgg?cctacgtcat?ccagatgctg?tagtggaaac?cagctcttta?tccagtgtta?????600ctcctcctga?tgtttggtac?aaaacatcca?tttctgagga?aaccattgat?aatggctggt?????660tatcagcatt?gcagcttgag?gcaattacat?atgcagccca?gcaacatgaa?actttcctac?????720ctaatggaga?tcgtgctggc?ttcttaatag?gtgatggtgc?cggtgtagga?aaaggaagga?????780cgatagcagg?aatcatctat?gaaaattatt?tgttgagtag?aaaacgagca?ttgtggttta?????840gtgtttcaaa?tgacttaaag?tatgatgctg?aaagagattt?aagggatatt?ggagcaaaaa?????900acattttggt?tcattcgtta?aataagttta?aatacggaaa?aatttcttcc?aaacataatg?????960ggagtgtgaa?aaagggtgtt?atttttgcta?cttactcttc?acttattggt?gaaagccagt????1020ctggcggcaa?gtataaaact?aggttaaaac?aacttctgca?ttggtgcggt?gatgacttcg????1080atggagtgat?agtgtttgat?gagtgtcata?aagccaaaaa?cttatgtcct?gttggttctt????1140caaagccaac?caagacaggc?ttagcagttt?tagagcttca?gaacaaattg?ccaaaagcca????1200gagttgttta?tgctagtgca?actggtgctt?ctgaaccacg?caacatggcc?tatatgaacc????1260gtcttggcat?atggggtgag?ggtactccat?ttagagaatt?cagtgatttt?attcaagcag????1320tagaacggag?aggagttggt?gccatggaaa?tagttgctat?ggatatgaag?cttagaggaa????1380tgtacattgc?tcgacaactg?agctttactg?gagtgacctt?caaaattgag?gaagttcttc????1440tttctcagag?ctacgttaaa?atgtataaca?aagctgtcaa?gctgtgggtc?attgccagag????1500agcggtttca?gcaagctgca?gatctgattg?atgctgagca?acgaatgaag?aagtccatgt????1560ggggtcagtt?ctggtctgct?caccagaggt?tcttcaaata?cttatgcata?gcatccaaag????1620ttaaaagggt?tgtgcaacta?gctcgagagg?aaatcaagaa?tggaaaatgt?gttgtaattg????1680gtctgcagtc?tacaggagaa?gctagaacat?tagaagcttt?ggaagagggc?gggggagaat????1740tgaatgattt?tgtttcaact?gccaaaggtg?tgttgcagtc?actcattgaa?aaacattttc????1800ctgctccaga?caggaaaaaa?ctttatagtt?tactaggaat?cgatttgaca?gctccaagta????1860acaacagttc?gccaagagat?agtccttgta?aagaaaataa?aataaagaag?cggaaaggtg????1920aagaaataac?tcgagaagcc?aaaaaagcac?gaaaagtagg?tggccttact?ggtagcagtt????1980ctgacgacag?tggaagtgaa?tctgatgcct?ctgataatga?agaaagtgac?tatgagagct????2040ctaaaaacat?gagttctgga?gatgatgacg?atttcaaccc?atttttagat?gagtctaatg????2100aggatgatga?aaatgatccc?tggttaatta?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa????2160aaaaaaaaaa?aaactcgag?????????????????????????????????????????????????2179

<210>153

<211>2109

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>153cagagagccc?caggcatcga?ggagaaggcg?gcggagaatg?gggccctggg?gtcccccgag??????60agagaagaga?aagtgctgga?gaatggggag?ctgacacccc?caaggaggga?ggagaaagcg?????120ctggagaatg?gggagctgag?gtccccagag?gccggggaga?aggtgctggt?gaatgggggc?????180ctgacacccc?caaagagcga?ggacaaggtg?tcagagaatg?ggggcctgag?attccccagg?????240aacacggaga?ggccaccaga?gactgggcct?tggagagccc?cagggccctg?ggagaagacg?????300cccgagagtt?ggggtccagc?ccccacgatc?ggggagccag?ccccagagac?ctctctggag?????360agagcccctg?cacccagcgc?agtggtctcc?tcccggaacg?gcggggagac?agcccctggc?????420ccccttggcc?cagcccccaa?gaacgggacg?ctggaacccg?ggaccgagag?gagagccccc?????480gagactgggg?gggcgccgag?agccccaggg?gctgggaggc?tggacctcgg?gagtgggggc?????540cgagccccag?tgggcacggg?gacggccccc?ggcggcggcc?ccggaagcgg?cgtggacgca?????600aaggccggat?gggtagacaa?cacgaggccg?cagccaccgc?cgccaccgct?gccaccgcca?????660ccggaggcac?agccgaggag?gctggagcca?gcgcccccga?gagccaggcc?ggaggtggcc?????720cccgagggag?agcccggggc?cccagacagc?agggccggcg?gagacacggc?actcagcgga?????780gacggggacc?cccccaagcc?cgagaggaag?ggccccgaga?tgccacgact?attcttggac?????840ttgggacccc?ctcaggggaa?cagcgagcag?atcaaagcca?ggctctcccg?gctctcgctg?????900gcgctgccgc?cgctcacgct?cacgccattc?ccggggccgg?gcccgcggcg?gcccccgtgg?????960gagggcgcgg?acgccggggc?ggctggcggg?gaggccggcg?gggcgggagc?gccggggccg????1020gcggaggagg?acggggagga?cgaggacgag?gacgaggagg?aggacgagga?ggcggcggcg????1080ccgggcgcgg?cggcggggcc?gcggggcccc?gggagggcgc?gagcagcccc?ggtgcccgtc????1140gtggtgagca?gcgccgacgc?ggacgcggcc?cgcccgctgc?gggggctgct?caagtctccg????1200cgcggggccg?acgagccaga?ggacagcgag?ctggagagga?agcgcaagat?ggtctccttc????1260cacggggacg?tgaccgtcta?cctcttcgac?caggagacgc?caaccaacga?gctgagcgtc????1320caggcccccc?ccgaggggga?cacggacccg?tcaacgcctc?cagcgccccc?gacacctccc????1380caccccgcca?cccccggaga?tgggtttccc?agcaacgaca?gcggctttgg?aggcagtttc????1440gagtgggcgg?aggatttccc?cctcctcccc?cctccaggcc?ccccgctgtg?cttctcccgc????1500ttctccgtct?cgcctgcgct?ggagaccccg?gggccacccg?cccgggcccc?cgacgcccgg????1560cccgcaggcc?ccgtggagaa?ttgattcccc?gaagacccga?ccccgctgca?ccctcagaag????1620aggggttgag?aatggaatcc?tctgtggatg?acggcgccac?tgccaccacc?gcagacgccg????1680cctctgggga?ggcccccgag?gctgggccct?ccccctccca?ctcccctacc?atgtgccaaa????1740cgggaggccc?cgggcccccg?cccccccagc?cccccagatg?gctcccctga?cccccctgac????1800cccctcggag?ccaaatgagg?caggaatccc?cccgcccctc?catagagagc?cgcctttctc????1860ggaactgaac?tgaactcttt?tgggcctgga?gcccctcgac?acagcggagg?tccctcctca????1920cccactcctg?gcccaagaca?ggggccgcag?gcttcgggga?cccggacccc?ccatttcgcg????1980tctccccttt?ccctccccag?cccggcccct?ggaggggcct?ctggttcaaa?ccttcgcgtg????2040gcattttcac?attatttaaa?aaagacaaaa?acaacttttt?ggaggaaaaa?aaaaaaaaaa????2100aaactcgag????????????????????????????????????????????????????????????2109

<210>154

<211>1411

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>154gaattcggca?ccaggggaga?tgaggaagtt?cgatgttcct?agcatggagt?ctacccttaa??????60ccagccagcc?atgctagaga?cgttatactc?agatccacat?taccgagccc?atttccccaa?????120cccaagacct?gatacaaata?aggatgtata?caaagtattg?ccagaatcca?agaaggcacc?????180gggcagtggt?gcagtatttg?agaggaacgg?accacatgct?agcagtagtg?gggtgctccc?????240tttgggactc?cagcctgcgc?ctggactttc?caagtcacta?tcctctcagg?tgtggcaacc?????300aagtcctgac?ccttggcatc?ctggagaaca?atcctgtgaa?ctcagtactt?gtcgacagca?????360gttggaattg?atccgtttac?agatggagca?aatgcagctt?cagaacggag?ccatgtgtca?????420ccatcctgct?gctttcgctc?cattactgcc?caccctagag?ccagcacagt?ggctcagcat?????480cctgaacagt?aacgagcatc?tcctgaagga?gaaggagctc?ctcattgaca?agcaaaggaa?????540gcatatctct?cagctggagc?agaaagtgcg?agagagtgaa?ctgcaagtcc?acagtgccct?????600tttgggccgc?cctgccccct?ttggggatgt?ctgcttattg?aggctacagg?agttgcagcg?????660agagaacact?ttcttacggg?cacagtttgc?acagaagaca?gaagccctga?gcaaggagaa?????720gatggagctt?gaaaagaaac?tctctgcatc?tgaagttgaa?attcagctca?ttagggagtc?????780tctaaaagtg?acactacaga?agcattcgga?ggaggggaag?aaacaggagg?aaagggtcaa?????840aggtcgtgat?aaacatatca?ataatttgaa?aaagaaatgt?cagaaggaat?cagagcagaa?????900ccgggagaag?cagcagcgta?ttgaaacctt?ggagcgctat?ctagctgacc?tgcccaccct?????960agaagaccat?cagaaacaga?cggagcagct?taaggacgct?gaattaaaga?acacagaact????1020gcaagagaga?gtggctgagc?tggagacttt?gctggaggac?acccaggcaa?cctgcagaga????1080gaaggaggtt?cagctggaaa?gtctgagaca?aagagaagca?gacctctcct?ctgctagaca????1140taggtaatgc?cctgtgtact?tgggggaagg?agggagttcg?gttctggtgc?tctgttaact????1200cttgtgtgtt?caacagtgtt?catttcaagt?tcctttcttc?taagagcttt?gtgttctttg????1260aattgaaagt?cacttatggc?cgggtgtggt?ggcgcacacc?tttaatccca?gcacttggga????1320gtcagaggca?ggctaatttc?tgagtttcag?gacagccagg?gctatacaga?gaaaccctgt????1380ctcaaacaaa?aaaaaaaaaa?aaaaactcga?g???????????????????????????????????1411

<210>155

<211>678

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>155ctggagtgaa?gggagctagt?ggtaaaggga?gctggtggag?gggtggcggc?aggggtaagg?????60ggcaggggac?accctctaga?cggagagcgg?gctccgaggt?cctggctggc?cctcggtgcg????120cccgcccctg?tgttggtccc?acaatccctg?gcaatgagag?gccagggttt?attggacaga????180gtcagttgtg?gggttcagag?ggtcagcaat?caatcaatcc?tccgaatcca?gagatttaga????240cccagtcgtc?cgtattagga?ctggaggggg?gtcaataggt?tcagtgtttg?agatgccaag????300ggaacctgtc?ttttgatttg?gggttcaaca?tacagagttc?aggtacctgc?aggaatttgc????360ccccctaggc?acagggggtg?gtctttacca?ttttcgagac?cagatcctgg?ctgggagccc????420cgaggcattc?ttcgtgctca?atgctgatgt?ctgctccgac?ttccccttga?gtgctatgtt????480ggaagcccac?cgacgccagc?gtcacccttt?cttactcctt?ggcactacgg?ctaacaggac????540gcaatccctc?aactacggct?gcatcgttga?gaatccacag?acacacgagg?tattgcacta????600tgtggagaaa?cccagcacat?ttatcagtga?catcatcaac?tgcggcacct?acctcttttc????660tcctgaagcc?ttgaagcc??????????????????????????????????????????????????678

<210>156

<211>2668

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>156gggaaggcgg?ctgcgctgct?gggcgggggc?gggagctgga?gccggagctg?gagccggggc??????60cggggcccgg?gtcagcgctt?gagccgggag?aagagtttga?gatcgtggac?cgaagccagc?????120tgcccggccc?aggcgacctg?cggagcgcaa?cgaggccgcg?ggcggccgag?ggctggtcgg?????180cgcccatcct?gaccctggca?cgcagggcca?ccgggaacct?gtcggcgagc?tgcgggagcg?????240cgctgcgcgc?ggccgcgggg?ctgggcggcg?gggacagcgg?ggacggcacg?gcgcgcgcag?????300cttctaagtg?ccagatgatg?gaggagcgtg?ccaacctgat?gcacatgatg?aaactcagca?????360tcaaggtgtt?gctccagtcg?gctctgagcc?tgggccgcag?cctggatgcg?gaccatgccc?????420ccttgcagca?gttctttgta?gtgatggagc?actgcctcaa?acatgggctg?aaagttaaga?????480agagttttat?tggccaaaat?aaatcattct?ttggtccttt?ggagctggtg?gagaaacttt?????540gtccagaagc?atcagatata?gcgactagtg?tcagaaatct?tccagaatta?aagacagctg?????600tgggaagagg?ccgagcgtgg?ctttatcttg?cactcatgca?aaagaaactg?gcagattatc?????660tgaaagtgct?tatagacaat?aaacatctct?taagcgagtt?ctatgagcct?gaggctttaa?????720tgatggagga?agaagggatg?gtgattgttg?gtctgctggt?gggactcaat?gttctcgatg?????780ccaatctctg?cttgaaagga?gaagacttgg?attctcaggt?tggagtaata?gatttttccc?????840tctaccttaa?ggatgtgcag?gatcttgatg?gtggcaagga?gcatgaaaga?attactgatg?????900tccttgatca?aaaaaattat?gtggaagaac?ttaaccggca?cttgagctgc?acagttgggg?????960atcttcaaac?caagatagat?ggcttggaaa?agactaactc?aaagcttcaa?gaagagcttt????1020cagctgcaac?agaccgaatt?tgctcacttc?aagaagaaca?gcagcagtta?agagaacaaa????1080atgaattaat?tcgagaaaga?agtgaaaaga?gtgtagagat?aacaaaacag?gataccaaag????1140ttgagctgga?gacttacaag?caaactcggc?aaggtctgga?tgaaatgtac?agtgatgtgt????1200ggaagcagct?aaaagaggag?aagaaagtcc?ggttggaact?ggaaaaagaa?ctggagttac????1260aaattggaat?gaaaaccgaa?atggaaattg?caatgaagtt?actggaaaag?gacacccacg????1320agaagcagga?cacactagtt?gccctccgcc?agcagctgga?agaagtcaaa?gcgattaatt????1380tacagatgtt?tcacaaagct?cagaatgcag?agagcagttt?gcagcagaag?aatgaagcca????1440tcacatcctt?tgaaggaaaa?accaaccaag?ttatgtccag?catgaaacaa?atggaagaaa????1500ggttgcagca?ctcggagcgg?gcgaggcagg?gggctgagga?gcggagccac?aagctgcagc????1560aggagctggg?cgggaggatc?ggcgccctgc?agctgcagct?ctcccagctg?cacgagcaat????1620gctcaagcct?ggagaaagaa?ttgaaatcag?aaaaagagca?aagacaggct?cttcagcgcg????1680aattacagca?cgagaaagac?acttcctctc?tactcaggat?ggagctgcaa?caagtggaag????1740gactgaaaaa?ggagttgcgg?gagcttcagg?acgagaaggc?agagctgcag?aagatctgcg????1800aggagcagga?acaagccctc?caggaaatgg?gcctgcacct?cagccagtcc?aagctgaaga????1860tggaagatat?aaaagaagtg?aaccaggcac?tgaagggcca?cgcctggctg?aaagatgacg????1920aagcgacaca?ctgtaggcag?tgtgagaagg?agttctccat?ttcccggaga?aagcaccact????1980gccggaactg?tggccacatc?ttctgcaaca?cctgctccag?caacgagctg?gccctgccct????2040cctaccccaa?gccggtgcga?gtgtgcgaca?gctgccacac?cctgctcctg?cagcgctgct????2100cctccacggc?ctcctgaacg?tccgtcctca?ggagcacagc?ctcacggaca?gtgccaaacc????2160ctgtgggtct?ccaggggctt?gggaaatgtg?ttctttccca?agagtatcaa?aggaaagaat????2220caaatttctt?gcccggtcac?tggcactcca?gaagacagcg?tgccggaacc?ggcagctctc????2280acctttctgt?gacttgttcg?gaattaactc?ctctggatgg?aaacttccat?cttacttggt????2340tacatcacgg?ctctggttca?gatacaactt?catgattttg?ctactatcat?ttttcacttt????2400tcaaagaatt?taacctattt?tacagcagtt?cagttctgct?agtgagtagt?tttcctctcc????2460taccttcctt?ctaaaaacct?gattcatgca?cagcgtttga?cacacatgga?gtctgccagt????2520gtgccttctc?tgcttcagac?aagagatctg?ccatttcatg?cccttgtgac?tacctatcat????2580tggccctgca?ataaaatcat?ttatttttca?aaaaaaaaaa?aaaaaaaaaa?aaaaaaaaaa????2640aaaaaaaaaa?aaaaaaaaaa?aactcgag???????????????????????????????????????2668

<210>157

<211>2313

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>157gaattcggca?ccaggccggg?cgggcgcctc?agccatggcc?ctgcgcaagg?aactgctcaa??????60gtccatctgg?tacgccttta?ccgcgctgga?cgtggagaag?agtggcaaag?tctccaagtc?????120ccagctcaag?gtgctgtccc?acaacctgta?cacggtcctg?cacatccccc?atgaccccgt?????180ggccctggag?gaacacttcc?gagatgatga?tgacggccct?gtgtccagcc?agggatacat?????240gccctacctc?aacaagtaca?tcctggacaa?ggtggaggag?ggggcttttg?ttaaagagca?????300ctttgatgag?ctgtgctgga?cgctgacggc?caagaagaac?tatcgggcag?atagcaacgg?????360gaacagtatg?ctctccaatc?aggatgcctt?ccgcctctgg?tgcctcttca?acttcctgtc?????420tgaggacaag?taccctctga?tcatggttcc?tgatgaggtg?gaatacctgc?tgaaaaaggt?????480actcagcagc?atgagcttgg?aggtgagctt?gggtgagctg?gaggagcttc?tggcccagga?????540ggcccaggtg?gcccagacca?ccggggggct?cagcgtctgg?cagttcctgg?agctcttcaa?????600ttcgggccgc?tgcctgcggg?gcgtgggccg?ggacaccctc?agcatggcca?tccacgaggt?????660ctaccaggag?ctcatccaag?atgtcctgaa?gcagggctac?ctgtggaagc?gagggcacct?????720gagaaggaac?tgggccgaac?gctggttcca?gctgcagccc?agctgcctct?gctactttgg?????780gagtgaagag?tgcaaagaga?aaaggggcat?tatcccgctg?gatgcacact?gctgcgtgga?????840ggtgctgcca?gaccgcgacg?gaaagcgctg?catgttctgt?gtgaagacag?ccacccgcac?????900gtatgagatg?agcgcctcag?acacgcgcca?gcgccaggag?tggacagctg?ccatccagat?????960ggcgatccgg?ctgcaggccg?aggggaagac?gtccctacac?aaggacctga?agcagaaacg????1020gcgcgagcag?cgggagcagc?gggagcggcg?ccgggcggcc?aaggaagagg?agctgctgcg????1080gctgcagcag?ctgcaggagg?agaaggagcg?gaagctgcag?gagctggagc?tgctgcagga????1140ggcgcagcgg?caggccgagc?ggctgctgca?ggaggaggag?gaacggcgcc?gcagccagca????1200ccgcgagctg?cagcaggcgc?tcgagggcca?actgcgcgag?gcggagcagg?cccgggcctc????1260catgcaggct?gagatggagc?tgaaggagga?ggaggctgcc?cggcagcggc?agcgcatcaa????1320ggagctggag?gagatgcagc?agcggttgca?ggaggccctg?caactagagg?tgaaagctcg????1380gcgagatgaa?gaatctgtgc?gaatcgctca?gaccagactg?ctggaagagg?aggaagagaa????1440gctgaagcag?ttgatgcagc?tgaaggagga?gcaggagcgc?tacatcgaac?gggcgcagca????1500ggagaaggaa?gagctgcagc?aggagatggc?acagcagagc?cgctccctgc?agcaggccca????1560gcagcagctg?gaggaggtgc?ggcagaaccg?gcagagggct?gacgaggatg?tggaggctgc????1620ccagagaaaa?ctgcgccagg?ccagcaccaa?cgtgaaacac?tggaatgtcc?agatgaaccg????1680gctgatgcat?ccaattgagc?ctggagataa?gcgtccggtc?acaagcagct?ccttctcagg????1740cttccagccc?cctctgcttg?cccaccgtga?ctcctcccta?aagcgcctga?cccgctgggg????1800atcccagggc?aacaggaccc?cctcgcccaa?cagcaatgag?cagcagaagt?ccctcaatgg????1860tggggatgag?gctcctgccc?cggcttccac?ccctcaggaa?gataaactgg?atccagcacc????1920agaaaattag?cctctcttag?ccccttgttc?ttcccaatgt?catatccacc?aggacctggc????1980cacagctggc?ctgtgggtga?tcccagctct?tactaggaga?gggagctgag?gtcctggtgc????2040caggggccca?ggccctccaa?ccataaacag?tccaggatgg?aacctggttc?acccttcata????2100ccagctccaa?gccccagacc?atgggagctg?tctgggatgt?tgatccttga?gaacttggcc????2160ctgtgcttta?gacccaagga?cccgattcct?gggctaggaa?agagagaaca?agcaagccgg????2220ggctacctgc?ccccaggtgg?ccaccaagtt?gtggaagcac?atttctaaat?aaaaactgct????2280cttagaatga?aaaaaaaaaa?aaaaaaactc?gag?????????????????????????????????2313

<210>158

<211>2114

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>158gaattcggca?cgaggaagaa?ctcgcctctg?ttgagtgtaa?gtagccaaac?aataaccaag??????60gagaataaca?gaaatgtcca?tttggagcac?tcagagcaga?atcctggttc?atcagcaggt?????120gacacctcag?cagcgcacca?ggtggtttta?ggagaaaact?tgatagccac?agccctttgt?????180ctttctggca?gtgggtctca?gtctgatttg?aaggatgtgg?ccagcacagc?aggagaggag?????240ggggacacaa?gccttcggga?gagcctccat?ccagtcactc?ggtctcttaa?ggcagggtgc?????300catactaagc?agcttgcctc?caggaattgc?tctgaagaga?aatccccaca?aacctccatc?????360ctaaaggaag?gtaacaggga?cacaagcttg?gatttccgac?ctgtagtgtc?tccagcaaat?????420ggggttgaag?gagtccgagt?ggatcaggat?gatgatcaag?atagctcttc?cctgaagctt?????480tctcagaaca?ttgctgtaca?gactgacttt?aagacagctg?attcagaggt?aaacacagat?????540caagatattg?aaaagaattt?ggataaaatg?atgacagaga?gaaccctgtt?gaaagagcgt?????600taccaggagg?tcctggacaa?acagaggcaa?gtggagaatc?agctccaagt?gcaattaaag?????660cagcttcagc?aaaggagaga?agaggaaatg?aagaatcacc?aggagatatt?aaaggctatt?????720caggatgtga?caataaagcg?ggaagaaaca?aagaagaaga?tagagaaaga?gaagaaggag?????780tttttgcaga?aggagcagga?tctgaaagct?gaaattgaga?agctttgtga?gaagggcaga?????840agagaggtgt?gggaaatgga?actggataga?ctcaagaatc?aggatggcga?aataaatagg?????900aacattatgg?aagagactga?acgggcctgg?aaggcagaga?tcttatcact?agagagccgg?????960aaagagttac?tggtactgaa?actagaagaa?gcagaaaaag?aggcagaatt?gcaccttact????1020tacctcaagt?caactccccc?aacactggag?acagttcgtt?ccaaacagga?gtgggagacg????1080agactgaatg?gagttcggat?aatgaaaaag?aatgttcgtg?accaatttaa?tagtcatatc????1140cagttagtga?ggaacggagc?caagctgagc?agccttcctc?aaatccctac?tcccacttta????1200cctccacccc?catcagagac?agacttcatg?cttcaggtgt?ttcaacccag?tccctctctg????1260gctcctcgga?tgcccttctc?cattgggcag?gtcacaatgc?ccatggttat?gcccagtgca????1320gatccccgct?ccttgtcttt?cccaatcctg?aaccctgccc?tttcccagcc?cagccagcct????1380tcctcacccc?ttcctggctc?ccatggcaga?aatagccctg?gcttgggttc?ccttgtcagc????1440cctggtgccg?aattcggcac?gaggtaccac?tggtctgtgt?gctagaggag?ggtgttgcca????1500tagaaccagt?ggccacagtt?gtggtggtgg?tggtcagcac?tgtgggggtg?tgggtggtcc????1560ccgggacgga?ggagggggtc?accgtgaagc?cactggttgt?gggtgtggtg?gttgtgctga????1620tccacactgg?aggcgtgcgt?gccgtccctg?ggctgaagga?gggggtgact?gtgaagcccg????1680tggttgtggt?agtcggcact?ttggtagtgt?gagctgttcc?tggggtggaa?gagggggtgg????1740ccacagagcc?ggtggccctg?gttgtggtgg?ccgtggtggt?aagcactgtg?gaggtgtggg????1800cagtctctgg?agtggaggag?ggtgtggctg?tggacatggt?ggccgtgggt?gtggtggtct????1860gtgataggcg?ggtccaggtg?gtgcccaggg?aggaggaggg?gatggctgta?aagctggtag????1920ctgtgggtgt?ggtggctgtg?cttctcagtg?ctggaagggc?ggttgcagtc?cctggactgg????1980agaagggagt?ggctttggag?ctggtgactg?tgggtgtcgt?ggccgtggtg?ctcacatgtg????2040gggtgccagc?agttgcctgg?gtggaggagg?cggtggccgt?ggatccggtg?ggcaccgtca????2100cgggagtact?tcta??????????????????????????????????????????????????????2114

<210>159

<211>278

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>159gaattcggca?caggtaactt?tgcctggggt?atttaaaaaa?aaaaaaaaaa?aaaaaaaaag?????60tcaaatatct?gagtactaat?ttcctgaaaa?gtatgttccg?atagatgaac?agatcattaa????120tgcagaatga?gaatcactcc?taaaataggt?aatggtaaaa?attaaattga?caattacctc????180tctctatgca?gaaggaaata?tcacctatat?gacatcatca?tcatctattg?atacttgctg????240gcagtgctaa?taatggtttt?aatgccaatt?tgtaagaa????????????????????????????278

<210>160

<211>848

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>160gaattcggca?cgagccccag?aggagctcgg?cctgcgctgc?gccacgatgt?ccggggagtc?????60agccaggagc?ttggggaagg?gaagcgcgcc?cccggggccg?gtcccggagg?gctcgatccg????120catctacagc?atgaggttct?gcccgtttgc?tgagaggacg?cgtctagtcc?tgaaggccaa????180gggaatcagg?catgaagtca?tcaatatcaa?cctgaaaaat?aagcctgagt?ggttctttaa????240gaaaaatccc?tttggtctgg?tgccagttct?ggaaaacagt?cagggtcagc?tgatctacga????300gtctgccatc?acctgtgagt?acctggatga?agcataccca?gggaagaagc?tgttgccgga????360tgacccctat?gagaaagctt?gccagaagat?gatcttagag?ttgttttcta?aggtgccatc????420cttggtagga?agctttatta?gaagccaaaa?taaagaagac?tatgctggcc?taaaagaaga????480atttcgtaaa?gaatttacca?agctagagga?ggttctgact?aataagaaga?cgaccttctt????540tggtggcaat?tctatctcta?tgattgatta?cctcatctgg?ccctggtttg?aacggctgga????600agcaatgaag?ttaaatgagt?gtgtagacca?cactccaaaa?ctgaaactgt?ggatggcagc????660catgaaggaa?gatcccacag?tctcagccct?gcttactagt?gagaaagact?ggcaaggttt????720cctagagctc?tacttacaga?acagccctga?ggcctgtgac?tatgggctct?gaagggggca????780ggagtcagca?ataaagctat?gtctgatatt?ttccttcact?aaaaaaaaaa?aaaaaaaaaa????840aactcgag?????????????????????????????????????????????????????????????848

<210>161

<211>432

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>161gaattcggca?cgagggcaga?ccaagatcct?ggaggaggac?ctggaacaga?tcaagctgtc?????60cttgagagag?cgaggccggg?agctgaccac?tcagaggcag?ctgatgcagg?aacgggcaga????120ggaagggaag?ggcccaagta?aagcacagcg?cgggagccta?gagcacatga?agctgatcct????180gcgtgataag?gagaaggagg?tggaatgtca?gcaggagcat?atccatgaac?tccaggagct????240caaagaccag?ctggagcagc?agctccaggg?cctgcacagg?aaggtaggtg?agaccagcct????300cctcctgtcc?cagcgagagc?aggaaatagt?ggtcctgcag?cagcaactgc?aggaagccag????360ggaacaaggg?gagctgaagg?agcagtcact?tcagagtcaa?ctggatgagg?cccagagagc????420cctagcccag?ag????????????????????????????????????????????????????????432

<210>162

<211>433

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>162gattcggcac?gagccggagc?tgggttgctc?ctgctcccgt?ctccaagtcc?tggtacctcc?????60ttcaagctgg?gagagggctc?tagtccctgg?ttctgaacac?tctggggttc?tcgggtgcag????120gccgccatga?gcaaacggaa?ggcgccgcag?gagactctca?acgggggaat?caccgacatg????180ctcacagaac?tcgcaaactt?tgagaagaac?gtgagccaag?ctatccacaa?gtacaatgct????240tacagaaaag?cagcatctgt?tatagcaaaa?tacccacaca?aaataaagag?tggagctgaa????300gctaagaaat?tgcctggagt?aggaacaaaa?attgctgaaa?agattgatga?gtttttagca????360actggaaaat?tacgtaaact?ggaaaagatt?cggcaggatg?atacgagttc?atccatcaat????420ttcctgactc?gag???????????????????????????????????????????????????????433

<210>163

<211>432

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>163gaattcggca?ccagatgagg?ccaacgaggt?gacggacagc?gcgtacatgg?gctccgagag?????60cacctacagt?gagtgtgaga?ccttcacgga?cgaggacacc?agcaccctgg?tgcaccctga????120gctgcaacct?gaaggggacg?cagacagtgc?cggcggctcg?gccgtgccct?ctgagtgcct????180ggacgccatg?gaggagcccg?accatggtgc?cctgctgctg?ctcccaggca?ggcctcaccc????240ccatggccag?tctgtcatca?cggtgatcgg?gggcgaggag?cactttgagg?actacggtga????300aggcagtgag?gcggagctgt?ccccagagac?cctatgcaac?gggcagctgg?gctgcagtga????360ccccgctttc?ctcacgccca?gtccgacaaa?gcggctctcc?agcaagaagg?tggcaaggta????420cctgcaccag?tc????????????????????????????????????????????????????????432

<210>164

<211>395

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>164gacacttgaa?tcatgggtga?cgttaaaaat?tttctgtatg?cctggtgtgg?caaaaggaag?????60atgaccccat?cctatgaaat?tagagcagtg?gggaacaaaa?acaggcagaa?attcatgtgt????120gaggttcagg?tggaaggtta?taattacact?ggcatgggaa?attccaccaa?taaaaaagat????180gcacaaagca?atgctgccag?agactttgtt?aactatttgg?ttcgaataaa?tgaaataaag????240agtgaagaag?ttccagcttt?tggggtagca?tctccgcccc?cacttactga?tactcctgac????300actacagcaa?atgctgaagg?catcttgttg?acatcgaata?tgactttgat?aataaatacc????360ggttcctgaa?aaaaaaaaaa?aaaaaaaaac?tcgag???????????????????????????????395

<210>165

<211>503

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>165gaattcggca?ccaggaacgc?tcggtgagag?gcggaggagc?ggtaactacc?ccggttgcgc?????60acagctcggc?gctccttccc?gctccctcac?acaccggcct?cagcccgcac?cggcagtaga????120agatggtgaa?agaaacaact?tactacgatg?ttttgggggt?caaacccaat?gctactcagg????180aagaattgaa?aaaggcttat?aggaaactgg?ccttgaagta?ccatcctgat?aagaacccaa????240atgaaggaga?gaagtttaaa?cagatttctc?aagcttacga?agttctctct?gatgcaaaga????300aaagggaatt?atatgacaaa?ggaggagaac?aggcaattaa?agagggtgga?gcaggtggcg????360gttttggctc?ccccatggac?atctttgata?tgttttttgg?aggaggagga?aggatgcaga????420gagaaaggag?aggtaaaaat?gttgtacatc?agctctcagt?aaccctagaa?gacttatata????480atggtgcaac?aagaaaactg?gct????????????????????????????????????????????503

<210>166

<211>893

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>166gaattcggca?cgagaggaac?ttctcttgac?gagaagagag?accaaggagg?ccaagcaggg?????60gctgggccag?aggtgccaac?atggggaaac?tgaggctcgg?ctcggaaggg?tgagagtgag????120actacatctc?aaaaaaaaaa?aaaaaaaaaa?aaaagaaaga?aaagaaaaga?aaaaagaaag????180aacggaagta?gttgtaggta?gtggtatggt?ggtatgagtc?tgttttctgt?tacttataac????240aacaacaaca?acaaaaaacg?ctgaaactgg?gtaatttata?aagaaaagga?aaaaaagcag????300aaaaaaatca?ggaagaagag?aaaggaaaag?aagacaaata?aatgaaattt?atgtattaca????360gttctgaagg?ctgagacatc?ccaggtcaag?ggtccacact?tggcgagggc?tttcttgctg????420gtggagactc?tttgtggagt?cctgggacag?tgcagaagga?tcacgcctcc?ctaccgctcc????480aagcccagcc?ctcagccatg?gcatgccccc?tggatcaggc?cattggcctc?ctcgtggcca????540tcttccacaa?gtactccggc?agggagggtg?acaagcacac?cctgagcaag?aaggagctga????600aggagctgat?ccagaaggag?ctcaccattg?gctcgaagct?gcaggatgct?gaaattgcaa????660ggctgatgga?agacttggac?cggaacaagg?accaggaggt?gaacttccag?gagtatgtca????720ccttcctggg?ggccttggct?ttgatctaca?atgaagccct?caagggctga?aaataaatag????780ggaagatgga?gacaccctct?gggggtcctc?tctgagtcaa?atccagtggt?gggtaattgt????840acaataaatt?ttttttggtc?aaatttaaaa?aaaaaaaaaa?aaaaaaactc?gag???????????893

<210>167

<211>549

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>167gaattcggca?cgagcccaga?tcccgaggtc?cgacagcgcc?cggcccagat?ccccacgcct?????60gccaggagca?agccgagagc?cagccggccg?gcgcactccg?actccgagca?gtctctgtcc????120ttcgacccga?gccccgcgcc?ctttccggga?cccctgcccc?gcgggcagcg?ctgccaacct????180gccggccatg?gagaccccgt?cccagcggcg?cgccacccgc?agcggggcgc?aggccagctc????240cactccgctg?tcgcccaccc?gcatcacccg?gctgcaggag?aaggaggacc?tgcaggagct????300caatgatcgc?ttggcggtct?acatcgaccg?tgtgcgctcg?ctggaaacgg?agaacgcagg????360gctgcgcctt?cgcatcaccg?agtctgaaga?ggtggtcagc?cgcgaggtgt?ccggcatcaa????420ggccgcctac?gaggccgagc?tcggggatgc?ccgcaagacc?cttgactcag?tagccaagga????480gcgcgcccgc?ctgcagctgg?agctgagcaa?agtgcgtgaa?gagtttaagg?agctgaaagc????540gcgcaatac????????????????????????????????????????????????????????????549

<210>168

<211>547

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>168gaattcggca?cgagatggcg?gcaggggtcg?aagcggcggc?ggaggtggcg?gcgacggaga?????60tcaaaatgga?ggaagagagc?ggcgcgcccg?gcgtgccgag?cggcaacggg?gctccgggcc????120ctaagggtga?aggagaacga?cctgctcaga?atgagaagag?gaaggagaaa?aacataaaaa????180gaggaggcaa?tcgctttgag?ccatatgcca?atccaactaa?aagatacaga?gccttcatta????240caaacatacc?ttttgatgtg?aaatggcagt?cacttaaaga?cctggttaaa?gaaaaagttg????300gtgaggtaac?atacgtggag?ctcttaatgg?acgctgaagg?aaagtcaagg?ggatgtgctg????360ttgttgaatt?caagatggaa?gagagcatga?aaaaagctgc?ggaagtccta?aacaagcata????420gtctgagcgg?aagaccactg?aaagtcaaag?aagatcctga?tggtgaacat?gccaggagag????480caatgcaaaa?ggctggaaga?cttggaagca?cagtatttgt?agcaaatctg?gattataaag????540ttggctg??????????????????????????????????????????????????????????????547

<210>169

<211>547

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>169gaattcggca?ccaggagtcc?gactgtgctc?gctgctcagc?gccgcacccg?gaagatgagg?????60ctcgccgtgg?gagccctgct?ggtctgcgcc?gtcctggggc?tgtgtctggc?tgtccctgat????120aaaactgtga?gatggtgtgc?agtgtcggag?catgaggcca?ctaagtgcca?gagtttccgc????180gaccatatga?aaagcgtcat?tccatccgat?ggtcccagtg?ttgcttgtgt?gaagaaagcc????240tcctaccttg?attgcatcag?ggccattgcg?gcaaacgaag?cggatgctgt?gacactggat????300gcaggtttgg?tgtatgatgc?ttacctggct?cccaataacc?tgaagcctgt?ggtggcagag????360ttctatgggt?caaaagagga?tccacagact?ttctattatg?ctgttgctgt?ggtgaagaag????420gatagtggct?tccagatgaa?ccagcttcga?ggcaagaagt?cctgccacac?gggtctaggc????480aggtccgctg?ggtggaacat?ccccataggc?ttactttact?gtgacttacc?tgagccacgt????540aaacctc??????????????????????????????????????????????????????????????547

<210>170

<211>838

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>170gaattcggca?ccagaggagc?tcggcctgcg?ctgcgccacg?atgtccgggg?agtcagccag?????60gagcttgggg?aagggaagcg?cgcccccggg?gccggtcccg?gagggctcga?tccgcatcta????120cagcatgagg?ttctgcccgt?ttgctgagag?gacgcgtcta?gtcctgaagg?ccaagggaat????180caggcatgaa?gtcatcaata?tcaacctgaa?aaataagcct?gagtggttct?ttaagaaaaa????240tccctttggt?ctggtgccag?ttctggaaaa?cagtcagggt?cagctgatct?acgagtctgc????300catcacctgt?gagtacctgg?atgaagcata?cccagggaag?aagctgttgc?cggatgaccc????360ctatgagaaa?gcttgccaga?agatgatctt?agagttgttt?tctaaggtgc?catccttggt????420aggaagcttt?attagaagcc?aaaataaaga?agactatgat?ggcctaaaag?aagaatttcg????480taaagaattt?accaagctag?aggaggttct?gactaataag?aagacgacct?tctttggtgg????540caattctatc?tctatgattg?attacctcat?ctggccctgg?tttgaacggc?tggaagcaat????600gaagttaaat?gagtgtgtag?accacactcc?aaaactgaaa?ctgtggatgg?cagccatgaa????660ggaagatccc?acagtctcag?ccctgcttac?tagtgagaaa?gactggcaag?gtttcctaga????720gctctactta?cagaacagcc?ctgaggcctg?tgactatggg?ctctgaaggg?ggcaggagtc????780agcaataaag?ctatgtctga?tattttcctt?cactaaaaaa?aaaaaaaaaa?aactcgag??????838

<210>171

<211>547

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>171gaattcggca?ccagcgggat?ttgggtcgca?gttcttgttt?gtggattgct?gtgatcgtca?????60cttgacaatg?cagatcttcg?tgaagactct?gactggtaag?accatcaccc?tcgaggttga????120gcccagtgac?accatcgaga?atgtcaaggc?aaagatccaa?gataaggaag?gcatccctcc????180tgaccagcag?aggctgatct?ttgctggaaa?acagctggaa?gatgggcgca?ccctgtctga????240ctacaacatc?cagaaagagt?ccaccctgca?cctggtgctc?cgtctcagag?gtgggatgca????300aatcttcgtg?aagacactca?ctggcaagac?catcaccctt?gaggtcgagc?ccagtgacac????360catcgagaac?gtcaaagcaa?agatccagga?caaggaaggc?attcctcctg?accagcagag????420gttgatcttt?gccggaaagc?agctggaaga?tgggcgcacc?ctgtctgact?acaacatcca????480gaaagagtct?accctgcacc?tggtgctccg?tctcagaggt?gggatgcaga?tcttcgtgaa????540gaccctg??????????????????????????????????????????????????????????????547

<210>172

<211>608

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>172gaattcggca?ccagagactt?ctccctctga?ggcctgcgca?cccctcctca?tcagcctgtc?????60caccctcatc?tacaatggtg?ccctgccatg?tcagtgcaac?cctcaaggtt?cactgagttc????120tgagtgcaac?cctcatggtg?gtcagtgcct?gtgcaagcct?ggagtggttg?ggcgccgctg????180tgacctctgt?gcccctggct?actatggctt?tggccccaca?ggctgtcaag?gcgcttgcct????240gggctgccgt?gatcacacag?ggggtgagca?ctgtgaaagg?tgcattgctg?gtttccacgg????300ggacccacgg?ctgccatatg?ggggccagtg?ccggccctgt?ccctgtcctg?aaggccctgg????360gagccaacgg?cactttgcta?cttcttgcca?ccaggatgaa?tattcccagc?agattgtgtg????420ccactgccgg?gcaggctata?cggggctgcg?atgtgaagct?tgtgcccctg?ggcactttgg????480ggacccatca?aggccaggtg?gccggtgcca?actgtgtgag?tgcagtggga?acattgaccc????540aatggatcct?gatgcctgtg?acccccacac?ggggcaatgc?ctgcgctgtt?tacaccacac????600agagggtc?????????????????????????????????????????????????????????????608

<210>173

<211>543

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>173gaattcggca?ccagagatca?tccgccagca?gggtctggcc?tcctacgact?acgtgcgccg?????60ccgcctcacg?gctgaggacc?tgttcgaggc?tcggatcatc?tctctcgaga?cctacaacct????120gctccgggag?ggcaccagga?gcctccgtga?ggctctcgag?gcggagtccg?cctggtgcta????180cctctatggc?acgggctccg?tggctggtgt?ctacctgccc?ggttccaggc?agacactgag????240catctaccag?gctctcaaga?aagggctgct?gagtgccgag?gtggcccgcc?tgctgctgga????300ggcacaggca?gccacaggct?tcctgctgga?cccggtgaag?ggggaacggc?tgactgtgga????360tgaagctgtg?cggaagggcc?tcgtggggcc?cgaactgcac?gaccgcctgc?tctcggctga????420gcgggcggtc?accggctacc?gtgaccccta?caccgagcag?accatctcgc?tcttccaggc????480catgaagaag?gaactgatcc?ctactgagga?ggccctgcgg?ctgtggatgc?ccagctggcc????540acc??????????????????????????????????????????????????????????????????543

<210>174

<211>548

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>174gaattcggca?cgagaaatgg?cggcaggggt?cgaagcggcg?gcggaggtgg?cggcgacgga?????60gatcaaaatg?gaggaagaga?gcggcgcgcc?cggcgtgccg?agcggcaacg?gggctccggg????120ccctaagggt?gaaggagaac?gacctgctca?gaatgagaag?aggaaggaga?aaaacataaa????180aagaggaggc?aatcgctttg?agccatatgc?caatccaact?aaaagataca?gagccttcat????240tacaaacata?ccttttgatg?tgaaatggca?gtcacttaaa?gacctggtta?aagaaaaagt????300tggtgaggta?acatacgtgg?agctcttaat?ggacgctgaa?ggaaagtcaa?ggggatgtgc????360tgttgttgaa?ttcaagatgg?aagagagcat?gaaaaaagct?gcggaagtcc?taaacaagca????420tagtctgagc?ggaagaccac?tgaaagtcaa?agaagatcct?gatggtgaac?atgccaggag????480agcaatgcaa?aaggtgatgg?ctacgactgg?tgggatgggt?atgggaccag?gtggcccagg????540aatgatta?????????????????????????????????????????????????????????????548

<210>175

<211>604

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>175gaattcggca?ccagaggacc?tccaggacat?gttcatcgtc?cataccatcg?aggagattga?????60gggcctgatc?tcagcccatg?accagttcaa?gtccaccctg?ccggacgccg?atagggagcg????120cgaggccatc?ctggccatcc?acaaggaggc?ccagaggatc?gctgagagca?accacatcaa????180gctgtcgggc?agcaacccct?acaccaccgt?caccccgcaa?atcatcaact?ccaagtggga????240gaaggtgcag?cagctggtgc?caaaacggga?ccatgccctc?ctggaggagc?agagcaagca????300gcagtccaac?gagcacctgc?gccgccagtt?cgccagccag?gccaatgttg?tggggccctg????360gatccagacc?aagatggagg?agatcgggcg?catctccatt?gagatgaacg?ggaccctgga????420ggaccagctg?agccacctga?agcagtatga?acgcagcatc?gtggactaca?agcccaacct????480ggacctgctg?gagcagcagc?accagcttat?ccaggaggcc?ctcatcttcg?acaacaagca????540caccaactat?accatggagc?acatccgcgt?gggctgggag?cagctgctca?ccaccattgc????600ccgg?????????????????????????????????????????????????????????????????604

<210>176

<211>486

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>176gaattcggca?ccagccaagc?tcactattga?atccacgccg?ttcaatgtcg?cagaggggaa?????60ggaggttctt?ctactcgccc?acaacctgcc?ccagaatcgt?attggttaca?gctggtacaa????120aggcgaaaga?gtggatggca?acagtctaat?tgtaggatat?gtaataggaa?ctcaacaagc????180taccccaggg?cccgcataca?gtggtcgaga?gacaatatac?cccaatgcat?ccctgctgat????240ccagaacgtc?acccagaatg?acacaggatt?ctatacccta?caagtcataa?agtcagatct????300tgtgaatgaa?gaagcaaccg?gacagttcca?tgtatacccg?gagctgccca?agccctccat????360ctccagcaac?aactccaacc?ccgtggagga?caaggatgct?gtggccttca?cctgtgaacc????420tgaggttcag?aacacaacct?acctgtggtg?ggtaaatggt?cagagcctcc?cggtcagtcc????480caaggc???????????????????????????????????????????????????????????????486

<210>177

<211>387

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>177gaattcggca?ccagggacag?cagaccagac?agtcacagca?gccttgacaa?aacgttcctg?????60gaactcaagc?tcttctccac?agaggaggac?agagcagaca?gcagagacca?tggagtctcc????120ctcggcccct?ccccacagat?ggtgcatccc?ctggcagagg?ctcctgctca?cagcctcact????180tctaaccttc?tggaacccgc?ccaccactgc?caagctcact?attgaatcca?cgccgttcaa????240tgtcgcagag?gggaaggagg?tgcttctact?tgtccacaat?ctgccccagc?atctttttgg????300ctacagctgg?tacaaaggtg?aaagagtgga?tggcaaccgt?caaattatag?gatatgtaat????360aggaactcaa?caagctaccc?cagggcc????????????????????????????????????????387

<210>178

<211>440

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>178gaattcggca?cgaggagaag?cagaaaaaca?aggaatttag?ccagacttta?gaaaatgaga?????60aaaatacctt?actgagtcag?atatcaacaa?aggatggtga?actaaaaatg?cttcaggagg????120aagtaaccaa?aatgaacctg?ttaaatcagc?aaatccaaga?agaactctct?agagttacca????180aactaaagga?gacagcagaa?gaagagaaag?atgatttgga?agagaggctt?atgaatcaat????240tagcagaact?taatggaagc?attgggaatt?actgtcagga?tgttacagat?gcccaaataa????300aaaatgagct?attggaatct?gaaatgaaga?accttaaaaa?gtgtgtgagt?gaattggaag????360aagaaaagca?gcagttagtc?aaggaaaaaa?ctaaggtgga?atcagaaata?cgaaaggaat????420atttggagaa??aatacaaggt???????????????????????????????????????????????440

<210>179

<211>443

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>179gaattcggca?ccagcggggg?gctacggcgg?cggctacggc?ggcgtcctga?ccgcgtccga?????60cgggctgctg?gcgggcaacg?agaagctaac?catgcagaac?ctcaacgacc?gcctggcctc????120ctacctggac?aaggtgcgcg?ccctggaggc?ggccaacggc?gagctagagg?tgaagatccg????180cgactggtac?cagaagcagg?ggcctgggcc?ctcccgcgac?tacagccact?actacacgac????240catccaggac?ctgcgggaca?agattcttgg?tgccaccatt?gagaactcca?ggattgtcct????300gcagatcgac?aacgcccgtc?tggctgcaga?tgacttccga?accaagtttg?agacggaaca????360ggctctgcgc?atgagcgtgg?aggccgacat?caacggcctg?cgcagggtgc?tggatgagct????420gaccctggcc?aggaccgacc?tgg????????????????????????????????????????????443

<210>180

<211>403

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>180gaattcggca?cgaggttatg?agagtcgact?tcaatgttcc?tatgaagaac?aaccagataa?????60caaacaacca?gaggattaag?gctgctgtcc?caagcatcaa?attctgcttg?gacaatggag????120ccaagtcggt?agtccttatg?agccacctag?gccggcctga?tggtgtgccc?atgcctgaca????180agtactcctt?agagccagtt?gctgtagaac?tcagatctct?gctgggcaag?gatgttctgt????240tcttgaagga?ctgtgtaggc?ccagaagtgg?agaaagcctg?tgccaaccca?gctgctgggt????300ctgtcatcct?gctggagaac?ctccgctttc?atgtggagga?agaagggaag?ggaaaagatg????360cttctgggaa?caaggttaaa?gccgagccag?ccaaaataga?agc??????????????????????403

<210>181

<211>493

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>181gaattcggca?ccagcagagg?tctccagagc?cttctctctc?ctgtgcaaaa?tggcaactct?????60taaggaaaaa?ctcattgcac?cagttgcgga?agaagaggca?acagttccaa?acaataagat????120cactgtagtg?ggtgttggac?aagttggtat?ggcgtgtgct?atcagcattc?tgggaaagtc????180tctggctgat?gaacttgctc?ttgtggatgt?tttggaagat?aagcttaaag?gagaaatgat????240ggatctgcag?catgggagct?tatttcttca?gacacctaaa?attgtggcag?ataaagatta????300ttctgtgacc?gccaattcta?agattgtagt?ggtaactgca?ggagtccgtc?agcaagaagg????360ggagagtcgg?ctcaatctgg?tgcagagaaa?tgttaatgtc?ttcaaattca?ttattcctca????420gatcgtcaag?tacagtcctg?attgcatcat?aattgtggtt?tccaacccag?tggacattct????480tacgtatgtt?acc???????????????????????????????????????????????????????493

<210>182

<211>209

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>182Ala?Phe?Ser?Ser?Asn?Pro?Lys?Val?Gln?Val?Glu?Ala?Ile?Glu?Gly?Gly?1???????????????5??????????????????10??????????????????15Ala?Leu?Gln?Lys?Leu?Leu?Val?Ile?Leu?Ala?Thr?Glu?Gln?Pro?Leu?Thr

20??????????????????25??????????????????30Ala?Lys?Lys?Lys?Val?Leu?Phe?Ala?Leu?Cys?Ser?Leu?Leu?Arg?His?Phe

35??????????????????40??????????????????45Pro?Tyr?Ala?Gln?Arg?Gln?Phe?Leu?Lys?Leu?Gly?Gly?Leu?Gln?Val?Leu

50??????????????????55??????????????????60Arg?Thr?Leu?Val?Gln?Glu?Lys?Gly?Thr?Glu?Val?Leu?Ala?Val?Arg?Val65??????????????????70??????????????????75??????????????????80Val?Thr?Leu?Leu?Tyr?Asp?Leu?Val?Thr?Glu?Lys?Met?Phe?Ala?Glu?Glu

85??????????????????90??????????????????95Glu?Ala?Glu?Leu?Thr?Gln?Glu?Met?Ser?Pro?Glu?Lys?Leu?Gln?Gln?Tyr

100?????????????????105?????????????????110Arg?Gln?Val?His?Leu?Leu?Pro?Gly?Leu?Trp?Glu?Gln?Gly?Trp?Cys?Glu

115?????????????????120?????????????????125Ile?Thr?Ala?His?Leu?Leu?Ala?Leu?Pro?Glu?His?Asp?Ala?Arg?Glu?Lys

130?????????????????135?????????????????140Val?Leu?Gln?Thr?Leu?Gly?Val?Leu?Leu?Thr?Thr?Cys?Arg?Asp?Arg?Tyr145?????????????????150?????????????????155?????????????????160Arg?Gln?Asp?Pro?Gln?Leu?Gly?Arg?Thr?Leu?Ala?Ser?Leu?Gln?Ala?Glu

165?????????????????170?????????????????175Tyr?Gln?Val?Leu?Ala?Ser?Leu?Glu?Leu?Gln?Asp?Gly?Glu?Asp?Glu?Gly

180?????????????????185?????????????????190Tyr?Phe?Gln?Glu?Leu?Leu?Gly?Ser?Val?Asn?Ser?Leu?Leu?Lys?Glu?Leu

195?????????????????200?????????????????205Arg

<210>183

<211>255

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>183Met?Ala?Ala?Gly?Val?Glu?Ala?Ala?Ala?Glu?Val?Ala?Ala?Thr?Glu?Pro?1???????????????5??????????????????10??????????????????15Lys?Met?Glu?Glu?Glu?Ser?Gly?Ala?Pro?Cys?Val?Pro?Ser?Gly?Asn?Gly

20??????????????????25??????????????????30Ala?Pro?Gly?Pro?Lys?Gly?Glu?Glu?Arg?Pro?Thr?Gln?Asn?Glu?Lys?Arg

35??????????????????40??????????????????45Lys?Glu?Lys?Asn?Ile?Lys?Arg?Gly?Gly?Asn?Arg?Phe?Glu?Pro?Tyr?Ser

50??????????????????55??????????????????60Asn?Pro?Thr?Lys?Arg?Tyr?Arg?Ala?Phe?Ile?Thr?Asn?Ile?Pro?Phe?Asp65??????????????????70??????????????????75??????????????????80Val?Lys?Trp?Gln?Ser?Leu?Lys?Asp?Leu?Val?Lys?Glu?Lys?Val?Gly?Glu

85??????????????????90??????????????????95Val?Thr?Tyr?Val?Glu?Leu?Leu?Met?Asp?Ala?Glu?Gly?Lys?Ser?Arg?Gly

100?????????????????105?????????????????110Cys?Ala?Val?Val?Glu?Phe?Lys?Met?Glu?Glu?Ser?Met?Lys?Lys?Ala?Ala

115?????????????????120?????????????????125Glu?Val?Leu?Asn?Lys?His?Ser?Leu?Ser?Gly?Arg?Pro?Leu?Lys?Val?Lys

130?????????????????135?????????????????140Glu?Asp?Pro?Asp?Gly?Glu?His?Ala?Arg?Arg?Ala?Met?Gln?Lys?Ala?Gly145?????????????????150?????????????????155?????????????????160Arg?Leu?Gly?Ser?Thr?Val?Phe?Val?Ala?Asn?Leu?Asp?Tyr?Lys?Val?Gly

165?????????????????170?????????????????175Trp?Lys?Lys?Leu?Lys?Glu?Val?Phe?Ser?Met?Ala?Gly?Val?Val?Val?Arg

180?????????????????185?????????????????190Ala?Asp?Ile?Leu?Glu?Asp?Lys?Asp?Gly?Lys?Ser?Arg?Gly?Ile?Gly?Ile

195?????????????????200?????????????????205Val?Thr?Phe?Glu?Gln?Ser?Ile?Glu?Ala?Val?Gln?Ala?Ile?Ser?Met?Phe

210?????????????????215?????????????????220Asn?Gly?Gln?Leu?Leu?Phe?Asp?Arg?Pro?Met?His?Val?Lys?Met?Asp?Glu225?????????????????230?????????????????235?????????????????240Arg?Ala?Leu?Pro?Lys?Gly?Asp?Phe?Phe?Pro?Pro?Glu?Arg?His?Ser

245?????????????????250?????????????????255

<210>184

<211>188

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>184Leu?Ser?Gly?Ser?Cys?Ile?Arg?Arg?Glu?Gln?Thr?Pro?Glu?Lys?Glu?Lys?1???????????????5??????????????????10??????????????????15Gln?Val?Val?Leu?Phe?Glu?Glu?Ala?Ser?Trp?Thr?Cys?Thr?Pro?Ala?Cys

20??????????????????25??????????????????30Gly?Asp?Glu?Pro?Arg?Thr?Val?Ile?Leu?Leu?Ser?Ser?Met?Leu?Ala?Asp

35??????????????????40??????????????????45His?Arg?Leu?Lys?Leu?Glu?Asp?Tyr?Lys?Asp?Arg?Leu?Lys?Ser?Gly?Glu

50??????????????????55??????????????????60His?Leu?Asn?Pro?Asp?Gln?Leu?Glu?Ala?Val?Glu?Lys?Tyr?Glu?Glu?Val65??????????????????70??????????????????75??????????????????80Leu?His?Asn?Leu?Glu?Phe?Ala?Lys?Glu?Leu?Gln?Lys?Thr?Phe?Ser?Gly

85??????????????????90??????????????????95Leu?Ser?Leu?Asp?Leu?Leu?Lys?Ala?Gln?Lys?Lys?Ala?Gln?Arg?Arg?Glu

100?????????????????105?????????????????110His?Met?Leu?Lys?Leu?Glu?Ala?G1u?Lys?Lys?Lys?Leu?Arg?Thr?Ile?Leu

115?????????????????120?????????????????125Gln?Val?Gln?Tyr?Val?Leu?Gln?Asn?Leu?Thr?Gln?Glu?His?Val?Gln?Lys

130?????????????????135?????????????????140Asp?Phe?Lys?Gly?Gly?Leu?Asn?Gly?Ala?Val?Tyr?Leu?Pro?Ser?Lys?Glu145?????????????????150?????????????????155?????????????????160Leu?Asp?Tyr?Leu?Ile?Lys?Phe?Ser?Lys?Leu?Thr?Cys?Pro?Glu?Arg?Asn

165?????????????????170?????????????????175Glu?Ser?Leu?Arg?Gln?Thr?Leu?Glu?Gly?Ser?Thr?Val

180?????????????????185

<210>185

<211>746

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>185Asp?Lys?His?Leu?Lys?Asp?Leu?Leu?Ser?Lys?Leu?Leu?Asn?Ser?Gly?Tyr?1???????????????5??????????????????10??????????????????15Phe?Glu?Ser?Ile?Pro?Val?Pro?Lys?Asn?Ala?Lys?Glu?Lys?Glu?Val?Pro

20??????????????????25??????????????????30Leu?Glu?Glu?Glu?Met?Leu?Ile?Gln?Ser?Glu?Lys?Lys?Thr?Gln?Leu?Ser

35??????????????????40??????????????????45Lys?Thr?Glu?Ser?Val?Lys?Glu?Ser?Glu?Ser?Leu?Met?Glu?Phe?Ala?Gln

50??????????????????55??????????????????60Pro?Glu?Ile?Gln?Pro?Gln?Glu?Phe?Leu?Asn?Arg?Arg?Tyr?Met?Thr?Glu65??????????????????70??????????????????75??????????????????80Val?Asp?Tyr?Ser?Asn?Lys?Gln?Gly?Glu?Glu?Gln?Pro?Trp?Glu?Ala?Asp

85??????????????????90??????????????????95Tyr?Ala?Arg?Lys?Pro?Asn?Leu?Pro?Lys?Arg?Trp?Asp?Met?Leu?Thr?Glu

100?????????????????105?????????????????110Pro?Asp?Gly?Gln?Glu?Lys?Lys?Gln?Glu?Ser?Phe?Lys?Ser?Trp?Glu?Ala

115?????????????????120?????????????????125Ser?Gly?Lys?His?Gln?Glu?Val?Ser?Lys?Pro?Ala?Val?Ser?Leu?Glu?Gln

130?????????????????135?????????????????140Arg?Lys?Gln?Asp?Thr?Ser?Lys?Leu?Arg?Ser?Thr?Leu?Pro?Glu?Glu?Gln145?????????????????150?????????????????155?????????????????160Lys?Lys?Gln?Glu?Ile?Ser?Lys?Ser?Lys?Pro?Ser?Pro?Ser?Gln?Trp?Lys

165?????????????????170?????????????????175Gln?Asp?Thr?Pro?Lys?Ser?Lys?Ala?Gly?Tyr?Val?Gln?Glu?Glu?Gln?Lys

180?????????????????185?????????????????190Lys?Gln?Glu?Thr?Pro?Lys?Leu?Trp?Pro?Val?Gln?Leu?Gln?Lys?Glu?Gln

195?????????????????200?????????????????205Asp?Pro?Lys?Lys?Gln?Thr?Pro?Lys?Ser?Trp?Thr?Pro?Ser?Met?Gln?Ser

210?????????????????215?????????????????220Glu?Gln?Asn?Thr?Thr?Lys?Ser?Trp?Thr?Thr?Pro?Met?Cys?Glu?Glu?Gln225?????????????????230?????????????????235?????????????????240Asp?Ser?Lys?Gln?Pro?Glu?Thr?Pro?Lys?Ser?Trp?Glu?Asn?Asn?Val?Glu

245?????????????????250?????????????????255Ser?Gln?Lys?His?Ser?Leu?Thr?Ser?Gln?Ser?Gln?Ile?Ser?Pro?Lys?Ser

260?????????????????265?????????????????270Trp?Gly?Val?Ala?Thr?Ala?Ser?Leu?Ile?Pro?Asn?Asp?Gln?Leu?Leu?Pro

275?????????????????280?????????????????285Arg?Lys?Leu?Asn?Thr?Glu?Pro?Lys?Asp?Val?Pro?Lys?Pro?Val?His?Gln

290?????????????????295?????????????????300Pro?Val?Gly?Ser?Ser?Ser?Thr?Leu?Pro?Lys?Asp?Pro?Val?Leu?Arg?Lys305?????????????????310?????????????????315?????????????????320Glu?Lys?Leu?Gln?Asp?Leu?Met?Thr?Gln?Ile?Gln?Gly?Thr?Cys?Asn?Phe

325?????????????????330?????????????????335Met?Gln?Glu?Ser?Val?Leu?Asp?Phe?Asp?Lys?Pro?Ser?Ser?Ala?Ile?Pro

340?????????????????345?????????????????350Thr?Ser?Gln?Pro?Pro?Ser?Ala?Thr?Pro?Gly?Ser?Pro?Val?Ala?Ser?Lys

355?????????????????360?????????????????365Glu?Gln?Asn?Leu?Ser?Ser?Gln?Ser?Asp?Phe?Leu?Gln?Glu?Pro?Leu?Gln

370?????????????????375?????????????????380Val?Phe?Asn?Val?Asn?Ala?Pro?Leu?Pro?Pro?Arg?Lys?Glu?Gln?Glu?Ile385?????????????????390?????????????????395?????????????????400Lys?Glu?Ser?Pro?Tyr?Ser?Pro?Gly?Tyr?Asn?Gln?Ser?Phe?Thr?Thr?Ala

405?????????????????410?????????????????415Ser?Thr?Gln?Thr?Pro?Pro?Gln?Cys?Gln?Leu?Pro?Ser?Ile?His?Val?Glu

420?????????????????425?????????????????430Gln?Thr?Val?His?Ser?Gln?Glu?Thr?Ala?Ala?Asn?Tyr?His?Pro?Asp?Gly

435?????????????????440?????????????????445Thr?Ile?Gln?Val?Ser?Asn?Gly?Ser?Leu?Ala?Phe?Tyr?Pro?Ala?Gln?Thr

450?????????????????455?????????????????460Asn?Val?Phe?Pro?Arg?Pro?Thr?Gln?Pro?Phe?Val?Asn?Ser?Arg?Gly?Ser465?????????????????470?????????????????475?????????????????480Val?Arg?Gly?Cys?Thr?Arg?Gly?Gly?Arg?Leu?Ile?Thr?Asn?Ser?Tyr?Arg

485?????????????????490?????????????????495Ser?Pro?Gly?Gly?Tyr?Lys?Gly?phe?Asp?Thr?Tyr?Arg?Gly?Leu?Pro?Ser

500?????????????????505?????????????????510Ile?Ser?Asn?Gly?Asn?Tyr?Ser?Gln?Leu?Gln?Phe?Gln?Ala?Arg?Glu?Tyr

515?????????????????520?????????????????525Ser?Gly?Ala?Pro?Tyr?Ser?Gln?Arg?Asp?Asn?Phe?Gln?Gln?Cys?Tyr?Lys

530?????????????????535?????????????????540Arg?Gly?Gly?Thr?Ser?Gly?Gly?Pro?Arg?Ala?Asn?Ser?Arg?Ala?Gly?Trp545?????????????????550?????????????????555?????????????????560Ser?Asp?Ser?Ser?Gln?Val?Ser?Ser?Pro?Glu?Arg?Asp?Asn?Glu?Thr?Phe

565?????????????????570?????????????????575Asn?Ser?Gly?Asp?Ser?Gly?Gln?Gly?Asp?Ser?Arg?Ser?Met?Thr?Pro?Val

580?????????????????585?????????????????590Asp?Val?Pro?Val?Thr?Asn?Pro?Ala?Ala?Thr?Ile?Leu?Pro?Val?His?Val

595?????????????????600?????????????????605Tyr?Pro?Leu?Pro?Gln?Gln?Met?Arg?Val?Ala?Phe?Ser?Ala?Ala?Arg?Thr

610?????????????????615?????????????????620Ser?Asn?Leu?Ala?Pro?GlV?Thr?Leu?Asp?Gln?Pro?Ile?Val?Phe?Asp?Leu625?????????????????630?????????????????635?????????????????640Leu?Leu?Asn?Asn?Leu?Gly?Glu?Thr?Phe?Asp?Leu?Gln?Leu?Gly?Arg?Phe

645?????????????????650?????????????????655Asn?Cys?Pro?Val?Asn?Gly?Thr?Tyr?Val?Phe?Ile?Phe?His?Met?Leu?Lys

660?????????????????665?????????????????670Leu?Ala?Val?Asn?Val?Pro?Leu?Tyr?Val?Asn?Leu?Met?Lys?Asn?Glu?Glu

675?????????????????680?????????????????685Val?Leu?Val?Ser?Ala?Tyr?Ala?Asn?Asp?Gly?Ala?Pro?Asp?His?Glu?Thr

690?????????????????695?????????????????700Ala?Ser?Asn?His?Ala?Ile?Leu?Gln?Leu?Phe?Gln?Gly?Asp?Gln?Ile?Trp705?????????????????710?????????????????715?????????????????720Leu?Arg?Leu?His?Arg?Gly?Ala?Ile?Tyr?Gly?Ser?Ser?Trp?Lys?Tyr?Ser

725?????????????????730?????????????????735Thr?Phe?Ser?Gly?Tyr?Leu?Leu?Tyr?Gln?Asp

740?????????????????745

<210>186

<211>705

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>186Ala?Leu?Leu?Asn?Val?Arg?Gln?Pro?Pro?Ser?Thr?Thr?Thr?Phe?Val?Leu?1???????????????5??????????????????10??????????????????15Asn?Gln?Ile?Asn?His?Leu?Pro?Pro?Leu?Gly?Ser?Thr?Ile?Val?Met?Thr

20??????????????????25??????????????????30Lys?Thr?Pro?Pro?Val?Thr?Thr?Asn?Arg?Gln?Thr?Ile?Thr?Leu?Thr?Lys

35??????????????????40??????????????????45Phe?Ile?Gln?Thr?Thr?Ala?Ser?Thr?Arg?Pro?Ser?Val?Ser?Ala?Pro?Thr

50??????????????????55??????????????????60Val?Arg?Asn?Ala?Met?Thr?Ser?Ala?Pro?Ser?Lys?Asp?Gln?Val?Gln?Leu65??????????????????70??????????????????75??????????????????80Lys?Asp?Leu?Leu?Lys?Asn?Asn?Ser?Leu?Asn?Glu?Leu?Met?Lys?Leu?Lys

85??????????????????90??????????????????95Pro?Pro?Ala?Asn?Ile?Ala?Gln?Pro?Val?Ala?Thr?Ala?Ala?Thr?Asp?Val

100?????????????????105?????????????????110Ser?Asn?Gly?Thr?Val?Lys?Lys?Glu?Ser?Ser?Asn?Lys?Glu?Gly?Ala?Arg

115?????????????????120?????????????????125Met?Trp?Ile?Asn?Asp?Met?Lys?Met?Arg?Ser?Phe?Ser?Pro?Thr?Met?Lys

130?????????????????135?????????????????140Val?Pro?Val?Val?Lys?Glu?Asp?Asp?Glu?Pro?Glu?Glu?Glu?Asp?Glu?Glu145?????????????????150?????????????????155?????????????????160Glu?Met?Gly?His?Ala?Glu?Thr?Tyr?Ala?Glu?Tyr?Met?Pro?Ile?Lys?Leu

165?????????????????170?????????????????175Lys?Ile?Gly?Leu?Arg?His?Pro?Asp?Ala?Val?Val?Glu?Thr?Ser?Ser?Leu

180?????????????????185?????????????????190Ser?Ser?Val?Thr?Pro?Pro?Asp?Val?Trp?Tyr?Lys?Thr?Ser?Ile?Ser?Glu

195?????????????????200?????????????????205Glu?Thr?Ile?Asp?Ash?Gly?Trp?Leu?Ser?Ala?Leu?Gln?Leu?Glu?Ala?Ile

210?????????????????215?????????????????220Thr?Tyr?Ala?Ala?Gln?Gln?His?Glu?Thr?Phe?Leu?Pro?Asn?Gly?Asp?Arg225?????????????????230?????????????????235?????????????????240Ala?Gly?Phe?Leu?Ile?Gly?Asp?Gly?Ala?Gly?Val?Gly?Lys?Gly?Arg?Thr

245?????????????????250?????????????????255Ile?Ala?Gly?Ile?Ile?Tyr?Glu?Asn?Tyr?Leu?Leu?Ser?Arg?Lys?Arg?Ala

260?????????????????265?????????????????270Leu?Trp?Phe?Ser?Val?Ser?Asn?Asp?Leu?Lys?Tyr?Asp?Ala?Glu?Arg?Asp

275?????????????????280?????????????????285Leu?Arg?Asp?Ile?Gly?Ala?Lys?Asn?Ile?Leu?Val?His?Ser?Leu?Asn?Lys

290?????????????????295?????????????????300Phe?Lys?Tyr?Gly?Lys?Ile?Ser?Ser?Lys?His?Asn?Gly?Ser?Val?Lys?Lys305?????????????????310?????????????????315?????????????????320Gly?Val?Ile?Phe?Ala?Thr?Tyr?Ser?Ser?Leu?Ile?Gly?Glu?Ser?Gln?Ser

325?????????????????330?????????????????335Gly?Gly?Lys?Tyr?Lys?Thr?Arg?Leu?Lys?Gln?Leu?Leu?His?Trp?Cys?Gly

340?????????????????345?????????????????350Asp?Asp?Phe?Asp?Gly?Val?Ile?Val?Phe?Asp?Glu?Cys?His?Lys?Ala?Lys

355?????????????????360?????????????????365Asn?Leu?Cys?Pro?Val?Gly?Ser?Ser?Lys?Pro?Thr?Lys?Thr?Gly?Leu?Ala

370?????????????????375?????????????????380Val?Leu?Glu?Leu?Gln?Asn?Lys?Leu?Pro?Lys?Ala?Arg?Val?Val?Tyr?Ala385?????????????????390?????????????????395?????????????????400Ser?Ala?Thr?Gly?Ala?Ser?Glu?Pro?Arg?Asn?Met?Ala?Tyr?Met?Asn?Arg

405?????????????????410?????????????????415Leu?Gly?Ile?Trp?Gly?Glu?Gly?Thr?Pro?Phe?Arg?Glu?Phe?Ser?Asp?Phe

420?????????????????425?????????????????430Ile?Gln?Ala?Val?Glu?Arg?Arg?Gly?Val?Gly?Ala?Met?Glu?Ile?Val?Ala

435?????????????????440?????????????????445Met?Asp?Met?Lys?Leu?Arg?Gly?Met?Tyr?Ile?Ala?Arg?Gln?Leu?Ser?Phe

450?????????????????455?????????????????460Thr?Gly?Val?Thr?Phe?Lys?Ile?Glu?Glu?Val?Leu?Leu?Ser?Gln?Ser?Tyr465?????????????????470?????????????????475?????????????????480Val?Lys?Met?Tyr?Asn?Lys?Ala?Val?Lys?Leu?Trp?Val?Ile?Ala?Arg?Glu

485?????????????????490?????????????????495Arg?Phe?Gln?Gln?Ala?Ala?Asp?Leu?Ile?Asp?Ala?Glu?Gln?Arg?Met?Lys

500?????????????????505?????????????????510Lys?Ser?Met?Trp?Gly?Gln?Phe?Trp?Ser?Ala?His?Gln?Arg?Phe?Phe?Lys

515?????????????????520?????????????????525Tyr?Leu?Cys?Ile?Ala?Ser?Lys?Val?Lys?Arg?Val?Val?Gln?Leu?Ala?Arg

530?????????????????535?????????????????540Glu?Glu?Ile?Lys?Asn?Gly?Lys?Cys?Val?Val?Ile?Gly?Leu?Gln?Ser?Thr545?????????????????550?????????????????555?????????????????560Gly?Glu?Ala?Arg?Thr?Leu?Glu?Ala?Leu?Glu?Glu?Gly?Gly?Gly?Glu?Leu

565?????????????????570?????????????????575Asn?Asp?Phe?Val?Ser?Thr?Ala?Lys?Gly?Val?Leu?Gln?Ser?Leu?Ile?Glu

580?????????????????585?????????????????590Lys?His?Phe?Pro?Ala?Pro?Asp?Arg?Lys?Lys?Leu?Tyr?Ser?Leu?Leu?Gly

595?????????????????600?????????????????605Ile?Asp?Leu?Thr?Ala?Pro?Ser?Asn?Asn?Ser?Ser?Pro?Arg?Asp?Ser?Pro

610?????????????????615?????????????????620Cys?Lys?Glu?Asn?Lys?Ile?Lys?Lys?Arg?Lys?Gly?Glu?Glu?Ile?Thr?Arg625?????????????????630?????????????????635?????????????????640Glu?Ala?Lys?Lys?Ala?Arg?Lys?Val?Gly?Gly?Leu?Thr?Gly?Ser?Ser?Ser

645?????????????????650?????????????????655Asp?Asp?Ser?Gly?Ser?Glu?Ser?Asp?Ala?Ser?Asp?Asn?Glu?Glu?Ser?Asp

660?????????????????665?????????????????670Tyr?Glu?Ser?Ser?Lys?Asn?Met?Ser?Ser?Gly?Asp?Asp?Asp?Asp?Phe?Asn

675?????????????????680?????????????????685Pro?Phe?Leu?Asp?Glu?Ser?Asn?Glu?Asp?Asp?Glu?Asn?Asp?Pro?Trp?Leu

690?????????????????695?????????????????700Ile705

<210>187

<211>595

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>187Glu?Ser?Pro?Arg?His?Arg?Gly?Glu?Gly?Gly?Gly?Glu?Trp?Gly?Pro?Gly?1???????????????5??????????????????10??????????????????15Val?Pro?Arg?Glu?Arg?Arg?Glu?Ser?Ala?Gly?Glu?Trp?Gly?Ala?Asp?Thr

20??????????????????25??????????????????30Pro?Lys?Glu?Gly?Gly?Glu?Ser?Ala?Gly?Glu?Trp?Gly?Ala?Glu?Val?Pro

35??????????????????40??????????????????45Arg?Gly?Arg?Gly?Glu?Gly?Ala?Gly?Glu?Trp?Gly?Pro?Asp?Thr?Pro?Lys

50??????????????????55??????????????????60Glu?Arg?Gly?Gln?Gly?Val?Arg?Glu?Trp?Gly?Pro?Glu?Ile?Pro?Gln?Glu65??????????????????70??????????????????75??????????????????80His?Gly?Glu?Ala?Thr?Arg?Asp?Trp?Ala?Leu?Glu?Ser?Pro?Arg?Ala?Leu

85??????????????????90??????????????????95Gly?Glu?Asp?Ala?Arg?Glu?Leu?Gly?Ser?Ser?Pro?His?Asp?Arg?Gly?Ala

100?????????????????105?????????????????110Ser?Pro?Arg?Asp?Leu?Ser?Gly?Glu?Ser?Pro?Cys?Thr?Gln?Arc?Ser?Gly

115?????????????????120?????????????????125Leu?Leu?Pro?Glu?Arg?Arg?Gly?Asp?Ser?Pro?Trp?Pro?Pro?Trp?Pro?Ser

130?????????????????135?????????????????140Pro?Gln?Glu?Arg?Asp?Ala?Gly?Thr?Arg?Asp?Arg?Glu?Glu?Ser?Pro?Arg145?????????????????150?????????????????155?????????????????160Asp?Trp?Gly?Gly?Ala?Glu?Ser?Pro?Arg?Gly?Trp?Glu?Ala?Gly?Pro?Arg

165?????????????????170?????????????????175Glu?Trp?Gly?Pro?Ser?Pro?Ser?Gly?His?Gly?Asp?Gly?Pro?Arg?Arg?Arg

180?????????????????185?????????????????190Pro?Arg?Lys?Arg?Arg?Gly?Arg?Lys?Gly?Arg?Met?Gly?Arg?Gln?His?Glu

195?????????????????200?????????????????205Ala?Ala?Ala?Thr?Ala?Ala?Thr?Ala?Ala?Thr?Ala?Thr?Gly?Gly?Thr?Ala

210?????????????????215?????????????????220Glu?Glu?Ala?Gly?Ala?Ser?Ala?Pro?Glu?Ser?Gln?Ala?Gly?Gly?Gly?Pro225?????????????????230?????????????????235?????????????????240Arg?Gly?Arg?Ala?Arg?Gly?Pro?Arg?Gln?Gln?Gly?Arg?Arg?Arg?His?Gly

245?????????????????250?????????????????255Thr?Gln?Arg?Arg?Arg?Gly?Pro?Pro?Gln?Ala?Arg?Glu?Glu?Gly?Pro?Arg

260?????????????????265?????????????????270Asp?Ala?Thr?Thr?Ile?Leu?Gly?Leu?Gly?Thr?Pro?Ser?Gly?Glu?Gln?Arg

275?????????????????280?????????????????285Ala?Asp?Gln?Ser?Gln?Ala?Leu?Pro?Ala?Leu?Ala?Gly?Ala?Ala?Ala?Ala

290?????????????????295?????????????????300His?Ala?His?Ala?Ile?Pro?Gly?Ala?Gly?Pro?Ala?Ala?Ala?Pro?Val?Gly305?????????????????310?????????????????315?????????????????320Gly?Arg?Gly?Arg?Arg?Gly?Gly?Trp?Arg?Gly?Gly?Arg?Arg?Gly?Gly?Ser

325?????????????????330?????????????????335Ala?Gly?Ala?Gly?Gly?Gly?Gly?Arg?Gly?Gly?Arg?Gly?Arg?Gly?Arg?Gly

340?????????????????345?????????????????350Gly?Gly?Arg?Gly?Gly?Gly?Gly?Ala?Gly?Arg?Gly?Gly?Gly?Ala?Ala?Gly

355?????????????????360?????????????????365Pro?Arg?Glu?Gly?Ala?Ser?Ser?Pro?Gly?Ala?Arg?Arg?Gly?Glu?Gln?Arg

370?????????????????375?????????????????380Arg?Arg?Gly?Arg?Gly?Pro?Pro?Ala?Ala?Gly?Ala?Ala?Gln?Val?Ser?Ala385?????????????????390?????????????????395?????????????????400Arg?Gly?Arg?Arg?Ala?Arg?Gly?Gln?Arg?Ala?Gly?Glu?Glu?Ala?Gln?Asp

405?????????????????410?????????????????415Gly?Leu?Leu?Pro?Arg?Gly?Arg?Asp?Arg?Leu?Pro?Leu?Arg?Pro?Gly?Asp

420?????????????????425?????????????????430Ala?Asn?Gln?Arg?Ala?Glu?Arg?Pro?Gly?Pro?Pro?Arg?Gly?Gly?His?Gly

435?????????????????440?????????????????445Pro?Val?Asn?Ala?Ser?Ser?Ala?Pro?Asp?Thr?Ser?Pro?Pro?Arg?His?Pro

450?????????????????455?????????????????460Arg?Arg?Trp?Val?Ser?Gln?Gln?Arg?Gln?Arg?Leu?Trp?Arg?Gln?Phe?Arg465?????????????????470?????????????????475?????????????????480Val?Gly?Gly?Gly?Phe?Pro?Pro?Pro?Pro?Pro?Ser?Arg?Pro?Pro?Ala?Val

485?????????????????490?????????????????495Leu?Leu?Pro?Leu?Leu?Arg?Leu?Ala?Cys?Ala?Gly?Asp?Pro?Gly?Ala?Thr

500?????????????????505?????????????????510Arg?Pro?Gly?Pro?Arg?Arg?Pro?Ala?Arg?Arg?Pro?Arg?Gly?Glu?Leu?Ile

515?????????????????520?????????????????525Pro?Arg?Arg?Pro?Asp?Pro?Ala?Ala?Pro?Ser?Glu?Glu?Gly?Leu?Arg?Met

530?????????????????535?????????????????540Glu?Ser?Ser?Val?Asp?Asp?Gly?Ala?Thr?Ala?Thr?Thr?Ala?Asp?Ala?Ala545?????????????????550?????????????????555?????????????????560Ser?Gly?Glu?Ala?Pro?Glu?Ala?Gly?Pro?Ser?Pro?Ser?His?Ser?Pro?Thr

565?????????????????570?????????????????575Met?Cys?Gln?Thr?Gly?Gly?Pro?Gly?Pro?Pro?Pro?Pro?Gln?Pro?Pro?Arg

580?????????????????585?????????????????590Trp?Leu?Pro

595

<210>188

<211>376

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>188Glu?Met?Arg?Lys?Phe?Asp?Val?Pro?Ser?Met?Glu?Ser?Thr?Leu?Asn?Gln?1???????????????5??????????????????10??????????????????15Pro?Ala?Met?Leu?Glu?Thr?Leu?Tyr?Ser?Asp?Pro?His?Tyr?Arg?Ala?His

20??????????????????25??????????????????30Phe?Pro?Asn?Pro?Arg?Pro?Asp?Thr?Asn?Lys?Asp?Val?Tyr?Lys?Val?Leu

35??????????????????40??????????????????45Pro?Glu?Ser?Lys?Lys?Ala?Pro?Gly?Ser?Gly?Ala?Val?Phe?Glu?Arg?Asn

50??????????????????55??????????????????60Gly?Pro?His?Ala?Ser?Ser?Ser?Gly?Val?Leu?Pro?Leu?Gly?Leu?Gln?Pro65??????????????????70??????????????????75??????????????????80Ala?Pro?Gly?Leu?Ser?Lys?Ser?Leu?Ser?Ser?Gln?Val?Trp?Gln?Pro?Ser

85??????????????????90??????????????????95Pro?Asp?Pro?Trp?His?Pro?Gly?Glu?Gln?Ser?Cys?Glu?Leu?Ser?Thr?Cys

100?????????????????105?????????????????110Arg?Gln?Gln?Leu?Glu?Leu?Ile?Arg?Leu?Gln?Met?Glu?Gln?Met?Gln?Leu

115?????????????????120?????????????????125Gln?Asn?Gly?Ala?Met?Cys?His?His?Pro?Ala?Ala?Phe?Ala?Pro?Leu?Leu

130?????????????????135?????????????????140Pro?Thr?Leu?Glu?Pro?Ala?Gln?Trp?Leu?Ser?Ile?Leu?Asn?Ser?Asn?Glu145?????????????????150?????????????????155?????????????????160His?Leu?Leu?Lys?Glu?Lys?Glu?Leu?Leu?Ile?Asp?Lys?Gln?Arg?Lys?His

165?????????????????170?????????????????175Ile?Ser?Gln?Leu?Glu?Gln?Lys?Val?Arg?Glu?Ser?Glu?Leu?Gln?Val?His

180?????????????????185?????????????????190Ser?Ala?Leu?Leu?Gly?Arg?Pro?Ala?Pro?Phe?Gly?Asp?Val?Cys?Leu?Leu

195?????????????????200?????????????????205Arg?Leu?Gln?Glu?Leu?Gln?Arg?Glu?Asn?Thr?Phe?Leu?Arg?Ala?Gln?Phe

210?????????????????215?????????????????220Ala?Gln?Lys?Thr?Glu?Ala?Leu?Ser?Lys?Glu?Lys?Met?Glu?Leu?Glu?Lys225?????????????????230?????????????????235?????????????????240Lys?Leu?Ser?Ala?Ser?Glu?Val?Glu?Ile?Gln?Leu?Ile?Arg?Glu?Ser?Leu

245?????????????????250?????????????????255Lys?Val?Thr?Leu?Gln?Lys?His?Ser?Glu?Glu?Gly?Lys?Lys?Gln?Glu?Glu

260?????????????????265?????????????????270Arg?Val?Lys?Gly?Arg?Asp?Lys?His?Ile?Asn?Asn?Leu?Lys?Lys?Lys?Cys

275?????????????????280?????????????????285Gln?Lys?Glu?Ser?Glu?Gln?Asn?Arg?Glu?Lys?Gln?Gln?Arg?Ile?Glu?Thr

290?????????????????295?????????????????300Leu?Glu?Arg?Tyr?Leu?Ala?Asp?Leu?Pro?Thr?Leu?Glu?Asp?His?Gln?Lys305?????????????????310?????????????????315?????????????????320Gln?Thr?Glu?Gln?Leu?Lys?Asp?Ala?Glu?Leu?Lys?Asn?Thr?Glu?Leu?Gln

325?????????????????330?????????????????335Glu?Arg?Val?Ala?Glu?Leu?Glu?Thr?Leu?Leu?Glu?Asp?Thr?Gln?Ala?Thr

340?????????????????345?????????????????350Cys?Arg?Glu?Lys?Glu?Val?Gln?Leu?Glu?Ser?Leu?Arg?Gln?Arg?Glu?Ala

355?????????????????360?????????????????365Asp?Leu?Ser?Ser?Ala?Arg?His?Arg

370?????????????????375

<210>189

<211>160

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>189Met?Leu?Glu?Ala?His?Arg?Arg?Gln?Arg?His?Pro?Phe?Leu?Leu?Leu?Gly?1???????????????5??????????????????10??????????????????15Thr?Thr?Ala?Asn?Arg?Thr?Gln?Ser?Leu?Asn?Tyr?Gly?Cys?Ile?Val?Glu

20??????????????????25??????????????????30Asn?Pro?Gln?Thr?His?Glu?Val?Leu?His?Tyr?Val?Glu?Lys?Pro?Ser?Thr

35??????????????????40??????????????????45Phe?Ile?Ser?Asp?Ile?Ile?Asn?Cys?Gly?Ile?Tyr?Leu?Phe?Ser?Pro?Glu

50??????????????????55??????????????????60Ala?Leu?Lys?Pro?Leu?Arg?Asp?Val?Phe?Gln?Arg?Asn?Gln?Gln?Asp?Gly65??????????????????70??????????????????75??????????????????80Gln?Leu?Glu?Asp?Ser?Pro?Gly?Leu?Trp?Pro?Gly?Ala?Gly?Thr?Ile?Arg

85??????????????????90??????????????????95Leu?Glu?Gln?Asp?Val?Phe?Ser?Ala?Leu?Ala?Gly?Gln?Gly?Gln?Ile?Tyr

100?????????????????105?????????????????110Val?His?Leu?Thr?Asp?Gly?Ile?Trp?Ser?Gln?Ile?Lys?Ser?Ala?Gly?Ser

115?????????????????120?????????????????125Ala?Leu?Tyr?Ala?Ser?Arg?Leu?Tyr?Leu?Ser?Arg?Tyr?Gln?Asp?Thr?His

130?????????????????135?????????????????140Pro?Glu?Arg?Leu?Ala?Lys?His?Thr?Pro?Gly?Gly?Pro?Trp?Ile?Arg?Gly145?????????????????150?????????????????155?????????????????160

<210>190

<211>146

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>190Met?Asp?Pro?Arg?Ala?Ser?Leu?Leu?Leu?Leu?Gly?Asn?Val?Tyr?Ile?His?1???????????????5??????????????????10??????????????????15Pro?Thr?Ala?Lys?Val?Ala?Pro?Ser?Ala?Val?Leu?Gly?Pro?Asn?Val?Ser

20??????????????????25??????????????????30Ile?Gly?Lys?Gly?Val?Thr?Val?Gly?Glu?Gly?Val?Arg?Leu?Arg?Glu?Ser

35??????????????????40??????????????????45Ile?Val?Leu?His?Gly?Ala?Thr?Leu?Gln?Glu?His?Thr?Cys?Val?Leu?His

50??????????????????55??????????????????60Ser?Ile?Val?Gly?Trp?Gly?Ser?Thr?Val?Gly?Arg?Trp?Ala?Arg?Val?Glu65??????????????????70??????????????????75??????????????????80Gly?Thr?Pro?Ser?Asp?Pro?Asn?Pro?Asn?Asp?Pro?Arg?Ala?Arg?Met?Asp

85??????????????????90??????????????????95Ser?Glu?Ser?Leu?Phe?Lys?Asp?Gly?Lys?Leu?Leu?Pro?Ala?Ile?Thr?Ile

100?????????????????105?????????????????1l0Leu?Gly?Cys?Arg?Val?Arg?Ile?Pro?Ala?Glu?Val?Leu?Ile?Leu?Asn?Ser

115?????????????????120?????????????????125Ile?Val?Leu?Pro?His?Lys?Glu?Leu?Ser?Arg?Ser?Phe?Thr?Asn?Gln?Ile

130?????????????????135?????????????????140Ile?Leu145

<210>191

<211>704

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>191Glu?Gly?Gly?Cys?Ala?Ala?Gly?Arg?Gly?Arg?Glu?Leu?Glu?Pro?Glu?Leu?1???????????????5??????????????????10??????????????????15Glu?Pro?Gly?Pro?Gly?Pro?Gly?Ser?Ala?Leu?Glu?Pro?Gly?Glu?Glu?Phe

20??????????????????25??????????????????30Glu?Ile?Val?Asp?Arg?Ser?Gln?Leu?Pro?Gly?Pro?Gly?Asp?Leu?Arg?Ser

35??????????????????40??????????????????45Ala?Thr?Arg?Pro?Arg?Ala?Ala?Glu?Gly?Trp?Ser?Ala?Pro?Ile?Leu?Thr

50??????????????????55??????????????????60Leu?Ala?Arg?Arg?Ala?Thr?Gly?Asn?Leu?Ser?Ala?Ser?Cys?Gly?Ser?Ala65??????????????????70??????????????????75??????????????????80Leu?Arg?Ala?Ala?Ala?Gly?Leu?Gly?Gly?Gly?Asp?Ser?Gly?Asp?Gly?Thr

85??????????????????90??????????????????95Ala?Arg?Ala?Ala?Ser?Lys?Cys?Gln?Met?Met?Glu?Glu?Arg?Ala?Asn?Leu

100?????????????????105?????????????????110Met?His?Met?Met?Lys?Leu?Ser?Ile?Lys?Val?Leu?Leu?Gln?Ser?Ala?Leu

115?????????????????120?????????????????125Ser?Leu?Gly?Arg?Ser?Leu?Asp?Ala?Asp?His?Ala?Pro?Leu?Gln?Gln?Phe

130?????????????????135?????????????????140Phe?Val?Val?Met?Glu?His?Cys?Leu?Lys?His?Gly?Leu?Lys?Val?Lys?Lys145?????????????????150?????????????????155?????????????????160Ser?Phe?Ile?Gly?Gln?Asn?Lys?Ser?Phe?Phe?Gly?Pro?Leu?Glu?Leu?Val

165?????????????????170?????????????????175Glu?Lys?Leu?Cys?Pro?Glu?Ala?Ser?Asp?Ile?Ala?Thr?Ser?Val?Arg?Asn

180?????????????????185?????????????????190Leu?Pro?Glu?Leu?Lys?Thr?Ala?Val?Gly?Arg?Gly?Arg?Ala?Trp?Leu?Tyr

195?????????????????200?????????????????205Leu?Ala?Leu?Met?Gln?Lys?Lys?Leu?Ala?Asp?Tyr?Leu?Lys?Val?Leu?Ile

210?????????????????215?????????????????220Asp?Asn?Lys?His?Leu?Leu?Ser?Glu?Phe?Tyr?Glu?Pro?Glu?Ala?Leu?Met225?????????????????230?????????????????235?????????????????240Met?Glu?Glu?Glu?Gly?Met?Val?Ile?Val?Gly?Leu?Leu?Val?Gly?Leu?Asn

245?????????????????250?????????????????255Val?Leu?Asp?Ala?Asn?Leu?Cys?Leu?Lys?Gly?Glu?Asp?Leu?Asp?Ser?Gln

260?????????????????265?????????????????270Val?Gly?Val?Ile?Asp?Phe?Ser?Leu?Tyr?Leu?Lys?Asp?Val?Gln?Asp?Leu

275?????????????????280?????????????????285Asp?Gly?Gly?Lys?Glu?His?Glu?Arg?Ile?Thr?Asp?Val?Leu?Asp?Gln?Lys

290?????????????????295?????????????????300Asn?Tyr?Val?Glu?Glu?Leu?Asn?Arg?His?Leu?Ser?Cys?Thr?Val?Gly?Asp305?????????????????310?????????????????315?????????????????320Leu?Gln?Thr?Lys?Ile?Asp?Gly?Leu?Glu?Lys?Thr?Asn?Ser?Lys?Leu?Gln

325?????????????????330?????????????????335Glu?Glu?Leu?Ser?Ala?Ala?Thr?Asp?Arg?Ile?Cys?Ser?Leu?Gln?Glu?Glu

340?????????????????345?????????????????350Gln?Gln?Gln?Leu?Arg?Glu?Gln?Asn?Glu?Leu?Ile?Arg?Glu?Arg?Ser?Glu

355?????????????????360?????????????????365Lys?Ser?Val?Glu?Ile?Thr?Lys?Gln?Asp?Thr?Lys?Val?Glu?Leu?Glu?Thr

370?????????????????375?????????????????380Tyr?Lys?Gln?Thr?Arg?Gln?Gly?Leu?Asp?Glu?Met?Tyr?Ser?Asp?Val?Trp385?????????????????390?????????????????395?????????????????400Lys?Gln?Leu?Lys?Glu?Glu?Lys?Lys?Val?Arg?Leu?Glu?Leu?Glu?Lys?Glu

405?????????????????410?????????????????415Leu?Glu?Leu?Gln?Ile?Gly?Met?Lys?Thr?Glu?Met?Glu?Ile?Ala?Met?Lys

420?????????????????425?????????????????430Leu?Leu?Glu?Lys?Asp?Thr?His?Glu?Lys?Gln?Asp?Thr?Leu?Val?Ala?Leu

435?????????????????440?????????????????445Arg?Gln?Gln?Leu?Glu?Glu?Val?Lys?Ala?Ile?Asn?Leu?Gln?Met?Phe?His

450?????????????????455?????????????????460Lys?Ala?Gln?Asn?Ala?Glu?Ser?Ser?Leu?Gln?Gln?Lys?Asn?Glu?Ala?Ile465?????????????????470?????????????????475?????????????????480Thr?Ser?Phe?Glu?Gly?Lys?Thr?Asn?Gln?Val?Met?Ser?Ser?Met?Lys?Gln

485?????????????????490?????????????????495Met?Glu?Glu?Arg?Leu?Gln?His?Ser?Glu?Arg?Ala?Arg?Gln?Gly?Ala?Glu

500?????????????????505?????????????????510Glu?Arg?Ser?His?Lys?Leu?Gln?Gln?Glu?Leu?Gly?Gly?Arg?Ile?Gly?Ala

515?????????????????520?????????????????525Leu?Gln?Leu?Gln?Leu?Ser?Gln?Leu?His?Glu?Gln?Cys?Ser?Ser?Leu?Glu

530?????????????????535?????????????????540Lys?Glu?Leu?Lys?Ser?Glu?Lys?Glu?Gln?Arg?Gln?Ala?Leu?Gln?Arg?Glu545?????????????????550?????????????????555?????????????????560Leu?Gln?His?Glu?Lys?Asp?Thr?Ser?Ser?Leu?Leu?Arg?Met?Glu?Leu?Gln

565?????????????????570?????????????????575Gln?Val?Glu?Gly?Leu?Lys?Lys?Glu?Leu?Arg?Glu?Leu?Gln?Asp?Glu?Lys

580?????????????????585?????????????????590Ala?Glu?Leu?Gln?Lys?Ile?Cys?Glu?Glu?Gln?Glu?Gln?Ala?Leu?Gln?Glu

595?????????????????600?????????????????605Met?Gly?Leu?His?Leu?Ser?Gln?Ser?Lys?Leu?Lys?Met?Glu?Asp?Ile?Lys

6l0?????????????????615?????????????????620Glu?Val?Asn?Gln?Ala?Leu?Lys?Gly?His?Ala?Trp?Leu?Lys?Asp?Asp?Glu625?????????????????630?????????????????635?????????????????640Ala?Thr?His?Cys?Arg?Gln?Cys?Glu?Lys?Glu?Phe?Ser?Ile?Ser?Arg?Arg

645?????????????????650?????????????????655Lys?His?His?Cys?Arg?Asn?Cys?Gly?His?Ile?Phe?Cys?Asn?Thr?Cys?Ser

660?????????????????665?????????????????670Ser?Asn?Glu?Leu?Ala?Leu?Pro?Ser?Tyr?Pro?Lys?Pro?Val?Arg?Val?Cys

675?????????????????680?????????????????685Asp?Ser?Cys?His?Thr?Leu?Leu?Leu?Gln?Arg?Cys?Ser?Ser?Thr?Ala?Ser

690?????????????????695?????????????????700

<210>192

<211>331

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>192Arg?Ala?Gly?Ala?Ser?Ala?Met?Ala?Leu?Arg?Lys?Glu?Leu?Leu?Lys?Ser?1???????????????5??????????????????10??????????????????15Ile?Trp?Tyr?Ala?Phe?Thr?Ala?Leu?Asp?Val?Glu?Lys?Ser?Gly?Lys?Val

20??????????????????25??????????????????30Ser?Lys?Ser?Gln?Leu?Lys?Val?Leu?Ser?His?Asn?Leu?Tyr?Thr?Val?Leu

35??????????????????40??????????????????45His?Ile?Pro?His?Asp?Pro?Val?Ala?Leu?Glu?Glu?His?Phe?Arg?Asp?Asp

50??????????????????55??????????????????60Asp?Asp?Gly?Pro?Val?Ser?Ser?Gln?Gly?Tyr?Met?Pro?Tyr?Leu?Asn?Lys65??????????????????70??????????????????75??????????????????80Tyr?Ile?Leu?Asp?Lys?Val?Glu?Glu?Gly?Ala?Phe?Val?Lys?Glu?His?Phe

85??????????????????90??????????????????95Asp?Glu?Leu?Cys?Trp?Thr?Leu?Thr?Ala?Lys?Lys?Asn?Tyr?Arg?Ala?Asp

100?????????????????105?????????????????110Ser?Asn?Gly?Asn?Ser?Met?Leu?Ser?Asn?Gln?Asp?Ala?Phe?Arg?Leu?Trp

115?????????????????120?????????????????125Cys?Leu?Phe?Asn?Phe?Leu?Ser?Glu?Asp?Lys?Tyr?Pro?Leu?Ile?Met?Val

130?????????????????135?????????????????140Pro?Asp?Glu?Val?Glu?Tyr?Leu?Leu?Lys?Lys?Val?Leu?Ser?Ser?Met?Ser145?????????????????150?????????????????155?????????????????160Leu?Glu?Val?Ser?Leu?Gly?Glu?Leu?Glu?Glu?Leu?Leu?Ala?Gln?Glu?Ala

165?????????????????170?????????????????175Gln?Val?Ala?Gln?Thr?Thr?Gly?Gly?Leu?Ser?Val?Trp?Gln?Phe?Leu?Glu

180?????????????????185?????????????????190Leu?Phe?Asn?Ser?Gly?Arg?Cys?Leu?Arg?Gly?Val?Gly?Arg?Asp?Thr?Leu

195?????????????????200?????????????????205Ser?Met?Ala?Ile?His?Glu?Val?Tyr?Gln?Glu?Leu?Ile?Gln?Asp?Val?Leu

210?????????????????215?????????????????220Lys?Gln?Gly?Tyr?Leu?Trp?Lys?Arg?Gly?His?Leu?Arg?Arg?Asn?Trp?Ala225?????????????????230?????????????????235?????????????????240Glu?Arg?Trp?Phe?Gln?Leu?Gln?Pro?Ser?Cys?Leu?Cys?Tyr?Phe?Gly?Ser

245?????????????????250?????????????????255Glu?Glu?Cys?Lys?Glu?Lys?Arg?Gly?Ile?Ile?Pro?Leu?Asp?Ala?His?Cys

260?????????????????265?????????????????270Cys?Val?Glu?Val?Leu?Pro?Asp?Arg?Asp?Gly?Lys?Arg?Cys?Met?Phe?Cys

275?????????????????280?????????????????285Val?Lys?Thr?Ala?Thr?Arg?Thr?Tyr?Glu?Met?Ser?Ala?Ser?Asp?Thr?Arg

290?????????????????295?????????????????300Gln?Arg?Gln?Glu?Trp?Thr?Ala?Ala?Ile?Gln?Met?Ala?Ile?Arg?Leu?Gln305?????????????????310?????????????????315?????????????????320Ala?Glu?Gly?Lys?Thr?Ser?Leu?His?Lys?Asp?Leu

325?????????????????330

<210>193

<211>475

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>193Lys?Asn?Ser?Pro?Leu?Leu?Ser?Val?Ser?Ser?Gln?Thr?Ile?Thr?Lys?Glu?1???????????????5??????????????????l0??????????????????15Asn?Asn?Arg?Asn?Val?His?Leu?Glu?His?Ser?Glu?Gln?Asn?Pro?Gly?Ser

20??????????????????25??????????????????30Ser?Ala?Gly?Asp?Thr?Ser?Ala?Ala?His?Gln?Val?Val?Leu?Gly?Glu?Asn

35??????????????????40??????????????????45Leu?Ile?Ala?Thr?Ala?Leu?Cys?Leu?Ser?Gly?Ser?Gly?Ser?Gln?Ser?Asp

50??????????????????55??????????????????60Leu?Lys?Asp?Val?Ala?Ser?Thr?Ala?Gly?Glu?Glu?Gly?Asp?Thr?Ser?Leu65??????????????????70??????????????????75??????????????????80Arg?Glu?Ser?Leu?His?Pro?Val?Thr?Arg?Ser?Leu?Lys?Ala?Gly?Cys?His

85??????????????????90??????????????????95Thr?Lys?Gln?Leu?Ala?Ser?Arg?Asn?Cys?Ser?Glu?Glu?Lys?Ser?Pro?Gln

100?????????????????105?????????????????110Thr?Ser?Ile?Leu?Lys?Glu?Gly?Asn?Arg?Asp?Thr?Ser?Leu?Asp?Phe?Arg

115?????????????????120?????????????????125Pro?Val?Val?Ser?Pro?Ala?Asn?Gly?Val?Glu?Gly?Val?Arg?Val?Asp?Gln

130?????????????????135?????????????????140Asp?Asp?Asp?Gln?Asp?Ser?Ser?Ser?Leu?Lys?Leu?Ser?Gln?Asn?Ile?Ala145?????????????????150?????????????????155?????????????????160Val?Gln?Thr?Asp?Phe?Lys?Thr?Ala?Asp?Ser?Glu?Val?Asn?Thr?Asp?Gln

165?????????????????170?????????????????175Asp?Ile?Glu?Lys?Asn?Leu?Asp?Lys?Met?Met?Thr?Glu?Arg?Thr?Leu?Leu

180?????????????????185?????????????????190Lys?Glu?Arg?Tyr?Gln?Glu?Val?Leu?Asp?Lys?Gln?Arg?Gln?Val?Glu?Asn

195?????????????????200?????????????????205Gln?Leu?Gln?Val?Gln?Leu?Lys?Gln?Leu?Gln?Gln?Arg?Arg?Glu?Glu?Glu

210?????????????????215?????????????????220Met?Lys?Asn?His?Gln?Glu?Ile?Leu?Lys?Ala?Ile?Gln?Asp?Val?Thr?Ile225?????????????????230?????????????????235?????????????????240Lys?Arg?Glu?Glu?Thr?Lys?Lys?Lys?Ile?Glu?Lys?Glu?Lys?Lys?Glu?Phe

245?????????????????250?????????????????255Leu?Gln?Lys?Glu?Gln?Asp?Leu?Lys?Ala?Glu?Ile?Glu?Lys?Leu?Cys?Glu

260?????????????????265?????????????????270Lys?Gly?Arg?Arg?Glu?Val?Trp?Glu?Met?Glu?Leu?Asp?Arg?Leu?Lys?Asn

275?????????????????280?????????????????285Gln?Asp?Gly?Glu?Ile?Asn?Arg?Asn?Ile?Met?Glu?Glu?Thr?Glu?Arg?Ala

290?????????????????295?????????????????300Trp?Lys?Ala?Glu?Ile?Leu?Ser?Leu?Glu?Ser?Arg?Lys?Glu?Leu?Leu?Val305?????????????????310?????????????????315?????????????????320Leu?Lys?Leu?Glu?Glu?Ala?Glu?Lys?Glu?Ala?Glu?Leu?His?Leu?Thr?Tyr

325?????????????????330?????????????????335Leu?Lys?Ser?Thr?Pro?Pro?Thr?Leu?Glu?Thr?Val?Arg?Ser?Lys?Gln?Glu

340?????????????????345?????????????????350Trp?Glu?Thr?Arg?Leu?Asn?Gly?Val?Arg?Ile?Met?Lys?Lys?Asn?Val?Arg

35S?????????????????360?????????????????365Asp?Gln?Phe?Asn?Ser?His?Ile?Gln?Leu?Val?Arg?Asn?Gly?Ala?Lys?Leu

370?????????????????375?????????????????380Ser?Ser?Leu?Pro?Gln?Ile?Pro?Thr?Pro?Thr?Leu?Pro?Pro?Pro?Pro?Ser385?????????????????390?????????????????395?????????????????400Glu?Thr?Asp?Phe?Met?Leu?Gln?Val?Phe?Gln?Pro?Ser?Pro?Ser?Leu?Ala

405?????????????????410?????????????????415Pro?Arg?Met?Pro?Phe?Ser?Ile?Gly?Gln?Val?Thr?Met?Pro?Met?Val?Met

420?????????????????425?????????????????430Pro?Ser?Ala?Asp?Pro?Arg?Ser?Leu?Ser?Phe?Pro?Ile?Leu?Asn?Pro?Ala

435?????????????????440?????????????????445Leu?Ser?Gln?Pro?Ser?Gln?Pro?Ser?Ser?Pro?Leu?Pro?Gly?Ser?His?Gly

450?????????????????455?????????????????460Arg?Asn?Ser?Pro?Gly?Leu?Gly?Ser?Leu?Val?Ser465?????????????????470?????????????????475

<210>194

<211>241

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>194Met?Ser?Gly?Glu?Ser?Ala?Arg?Ser?Leu?Gly?Lys?Gly?Ser?Ala?Pro?Pro?1???????????????5??????????????????10??????????????????15Gly?Pro?Val?Pro?Glu?Gly?Ser?Ile?Arg?Ile?Tyr?Ser?Met?Arg?Phe?Cys

20??????????????????25??????????????????30Pro?Phe?Ala?Glu?Arg?Thr?Arg?Leu?Val?Leu?Lys?Ala?Lys?Gly?Ile?Arg

35??????????????????40??????????????????45His?Glu?Val?Ile?Asn?Ile?Asn?Leu?Lys?Asn?Lys?Pro?Glu?Trp?Phe?Phe

50??????????????????55??????????????????60Lys?Lys?Asn?Pro?Phe?Gly?Leu?Val?Pro?Val?Leu?Glu?Asn?Ser?Gln?Gly65??????????????????70??????????????????75??????????????????80Gln?Leu?Ile?Tyr?Glu?Ser?Ala?Ile?Thr?Cys?Glu?Tyr?Leu?Asp?Glu?Ala

85??????????????????90??????????????????95Tyr?Pro?Gly?Lys?Lys?Leu?Leu?Pro?Asp?Asp?Pro?Tyr?Glu?Lys?Ala?Cys

100?????????????????105?????????????????110Gln?Lys?Met?Ile?Leu?Glu?Leu?Phe?Ser?Lys?Val?Pro?Ser?Leu?Val?Gly

115?????????????????120?????????????????125Ser?Phe?Ile?Arg?Ser?Gln?Asn?Lys?Glu?Asp?Tyr?Ala?Gly?Leu?Lys?Glu

130?????????????????135?????????????????140Glu?Phe?Arg?Lys?Glu?Phe?Thr?Lys?Leu?Glu?Glu?Val?Leu?Thr?Asn?Lys145?????????????????150?????????????????155?????????????????160Lys?Thr?Thr?Phe?Phe?Gly?Gly?Asn?Ser?Ile?Ser?Met?Ile?Asp?Tyr?Leu

165?????????????????170?????????????????175Ile?Trp?Pro?Trp?Phe?Glu?Arg?Leu?Glu?Ala?Met?Lys?Leu?Asn?Glu?Cys

180?????????????????185?????????????????190Val?Asp?His?Thr?Pro?Lys?Leu?Lys?Leu?Trp?Met?Ala?Ala?Met?Lys?Glu

195?????????????????200?????????????????205Asp?Pro?Thr?Val?Ser?Ala?Leu?Leu?Thr?Ser?Glu?Lys?Asp?Trp?Gln?Gly

210?????????????????215?????????????????220Phe?Leu?Glu?Leu?Tyr?Leu?Gln?Asn?Ser?Pro?Glu?Ala?Cys?Asp?Tyr?Gly225?????????????????230?????????????????235?????????????????240Leu

<210>195

<211>138

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>195Gln?Thr?Lys?Ile?Leu?Glu?Glu?Asp?Leu?Glu?Gln?Ile?Lys?Leu?Ser?Leu?1???????????????5??????????????????10??????????????????15Arg?Glu?Arg?Gly?Arg?Glu?Leu?Thr?Thr?Gln?Arg?Gln?Leu?Met?Gln?Glu

20??????????????????25??????????????????30Arg?Ala?Glu?Glu?Gly?Lys?Gly?Pro?Ser?Lys?Ala?Gln?Arg?Gly?Ser?Leu

35??????????????????40??????????????????45Glu?His?Met?Lys?Leu?Ile?Leu?Arg?Asp?Lys?Glu?Lys?Glu?Val?Glu?Cys

50??????????????????55??????????????????60Gln?Gln?Glu?His?Ile?His?Glu?Leu?Gln?Glu?Leu?Lys?Asp?Gln?Leu?Glu65??????????????????70??????????????????75??????????????????80Gln?Gln?Leu?Gln?Gly?Leu?His?Arg?Lys?Val?Gly?Glu?Thr?Ser?Leu?Leu

85??????????????????90??????????????????95Leu?Ser?Gln?Arg?Glu?Gln?Glu?Ile?Val?Val?Leu?Gln?Gln?Gln?Leu?Gln

100?????????????????105?????????????????110Glu?Ala?Arg?Glu?Gln?Gly?Glu?Leu?Lys?Glu?Gln?Ser?Leu?Gln?Ser?Gln

115?????????????????120?????????????????125Leu?Asp?Glu?Ala?Gln?Arg?Ala?Leu?Ala?Gln

130?????????????????135

<210>196

<211>102

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>196Met?Ser?Lys?Arg?Lys?Ala?Pro?Gln?Glu?Thr?Leu?Asn?Gly?Gly?Ile?Thr?1???????????????5??????????????????10??????????????????15Asp?Met?Leu?Thr?Glu?Leu?Ala?Asn?Phe?Glu?Lys?Asn?Val?Ser?Gln?Ala

20??????????????????25??????????????????30Ile?His?Lys?Tyr?Asn?Ala?Tyr?Arg?Lys?Ala?Ala?Ser?Val?Ile?Ala?Lys

35??????????????????40??????????????????45Tyr?Pro?His?Lys?Ile?Lys?Ser?Gly?Ala?Glu?Ala?Lys?Lys?Leu?Pro?Gly

50??????????????????55??????????????????60Val?Gly?Thr?Lys?Ile?Ala?Glu?Lys?Ile?Asp?Glu?Phe?Leu?Ala?Thr?Gly65??????????????????70??????????????????75??????????????????80Lys?Leu?Arg?Lys?Leu?Glu?Lys?Ile?Arg?Gln?Asp?Asp?Thr?Ser?Ser?Ser

85??????????????????90??????????????????95Ile?Asn?Phe?Leu?Thr?Arg

100

<210>197

<211>138

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>197Glu?Ala?Asn?Glu?Val?Thr?Asp?Ser?Ala?Tyr?Met?Gly?Ser?Glu?Ser?Thr?1???????????????5??????????????????10??????????????????15Tyr?Ser?Glu?Cys?Glu?Thr?Phe?Thr?Asp?Glu?Asp?Thr?Ser?Thr?Leu?Val

20??????????????????25??????????????????30His?Pro?Glu?Leu?Gln?Pro?Glu?Gly?Asp?Ala?Asp?Ser?Ala?Gly?Gly?Ser

35??????????????????40??????????????????45Ala?Val?Pro?Ser?Glu?Cys?Leu?Asp?Ala?Met?Glu?Glu?Pro?Asp?His?Gly

50??????????????????55??????????????????60Ala?Leu?Leu?Leu?Leu?Pro?Gly?Arg?Pro?His?Pro?His?Gly?Gln?Ser?Val65??????????????????70??????????????????75??????????????????80Ile?Thr?Val?Ile?Gly?Gly?Glu?Glu?His?Phe?Glu?Asp?Tyr?Gly?Glu?Gly

85??????????????????90??????????????????95Ser?Glu?Ala?Glu?Leu?Ser?Pro?Glu?Thr?Leu?Cys?Asn?Gly?Gln?Leu?Gly

100?????????????????105?????????????????110Cys?Ser?Asp?Pro?Ala?Phe?Leu?Thr?Pro?Ser?Pro?Thr?Lys?Arg?Leu?Ser

115?????????????????120?????????????????125Ser?Lys?Lys?Val?Ala?Arg?Tyr?Leu?His?Gln

130?????????????????135

<210>198

<211>100

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>198Met?Gly?Asp?Val?Lys?Asn?Phe?Leu?Tyr?Ala?Trp?Cys?Gly?Lys?Arg?Lys?1???????????????5??????????????????10??????????????????15Met?Thr?Pro?Ser?Tyr?Glu?Ile?Arg?Ala?Val?Gly?Asn?Lys?Asn?Arg?Gln

20??????????????????25??????????????????30Lys?Phe?Met?Cys?Glu?Val?Gln?Val?Glu?Gly?Tyr?Asn?Tyr?Thr?Gly?Met

35??????????????????40??????????????????45Gly?Asn?Ser?Thr?Asn?Lys?Lys?Asp?Ala?Gln?Ser?Asn?Ala?Ala?Arg?Asp

50??????????????????55??????????????????60Phe?Val?Asn?Tyr?Leu?Val?Arg?Ile?Asn?Glu?Ile?Lys?Ser?Glu?Glu?Val65??????????????????70??????????????????75??????????????????80Pro?Ala?Phe?Gly?Val?Ala?Ser?Pro?Pro?Pro?Leu?Thr?Asp?Thr?Pro?Asp

85??????????????????90??????????????????95Thr?Thr?Ala?Asn

100

<210>199

<211>127

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>199Met?Val?Lys?Glu?Thr?Thr?Tyr?Tyr?Asp?Val?Leu?Gly?Val?Lys?Pro?Asn?1???????????????5??????????????????10??????????????????15Ala?Thr?Gln?Glu?Glu?Leu?Lys?Lys?Ala?Tyr?Arg?Lys?Leu?Ala?Leu?Lys

20??????????????????25??????????????????30Tyr?His?Pro?Asp?Lys?Asn?Pro?Asn?Glu?Gly?Glu?Lys?Phe?Lys?Gln?Ile

35??????????????????40??????????????????45Ser?Gln?Ala?Tyr?Glu?Val?Leu?Ser?Asp?Ala?Lys?Lys?Arg?Glu?Leu?Tyr

50??????????????????55??????????????????60Asp?Lys?Gly?Gly?Glu?Gln?Ala?Ile?Lys?Glu?Gly?Gly?Ala?Gly?Gly?Gly65??????????????????70??????????????????75??????????????????80Phe?Gly?Ser?Pro?Met?Asp?Ile?Phe?Asp?Met?Phe?Phe?Gly?Gly?Gly?Gly

85??????????????????90??????????????????95Arg?Met?Gln?Arg?Glu?Arg?Arg?Gly?Lys?Asn?Val?Val?His?Gln?Leu?Ser

100?????????????????105?????????????????110Val?Thr?Leu?Glu?Asp?Leu?Tyr?Asn?Gly?Ala?Thr?Arg?Lys?Leu?Ala

115?????????????????120?????????????????125

<210>200

<211>90

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>200Met?Ala?Cys?Pro?Leu?Asp?Gln?Ala?Ile?Gly?Leu?Leu?Val?Ala?Ile?Phe?l???????????????5??????????????????l0??????????????????15His?Lys?Tyr?Ser?Gly?Arg?Glu?Gly?Asp?Lys?His?Thr?Leu?Ser?Lys?Lys

20??????????????????25??????????????????30Glu?Leu?Lys?Glu?Leu?Ile?Gln?Lys?Glu?Leu?Thr?Ile?Gly?Ser?Lys?Leu

35??????????????????40??????????????????45Gln?Asp?Ala?Glu?Ile?Ala?Arg?Leu?Met?Glu?Asp?Leu?Asp?Arg?Asn?Lys

50??????????????????55??????????????????60Asp?Gln?Glu?Val?Asn?Phe?Gln?Glu?Tyr?Val?Thr?Phe?Leu?Gly?Ala?Leu65??????????????????70??????????????????75??????????????????80Ala?Leu?Ile?Tyr?Asn?Glu?Ala?Leu?Lys?Gly

85??????????????????90

<210>201

<211>120

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>201Met?Glu?Thr?Pro?Ser?Gln?Arg?Arg?Ala?Thr?Arg?Ser?Gly?Ala?Gln?Ala?1???????????????5??????????????????10??????????????????15Ser?Ser?Thr?Pro?Leu?Ser?Pro?Thr?Arg?Ile?Thr?Arg?Leu?Gln?Glu?Lys

20??????????????????25??????????????????30Glu?Asp?Leu?Gln?Glu?Leu?Asn?Asp?Arg?Leu?Ala?Val?Tyr?Ile?Asp?Arg

35??????????????????40??????????????????45Val?Arg?Ser?Leu?Glu?Thr?Glu?Asn?Ala?Gly?Leu?Arg?Leu?Arg?Ile?Thr

50??????????????????55??????????????????60Glu?Ser?Glu?Glu?Val?Val?Ser?Arg?Glu?Val?Ser?Gly?Ile?Lys?Ala?Ala65??????????????????70??????????????????75??????????????????80Tyr?Glu?Ala?Glu?Leu?Gly?Asp?Ala?Arg?Lys?Thr?Leu?Asp?Ser?Val?Ala

85??????????????????90??????????????????95Lys?Glu?Arg?Ala?Arg?Leu?Gln?Leu?Glu?Leu?Ser?Lys?Val?Arg?Glu?Glu

100?????????????????105?????????????????110Phe?Lys?Glu?Leu?Lys?Ala?Arg?Asn

115?????????????????120

<210>202

<211>177

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>202Met?Ala?Ala?Gly?Val?Glu?Ala?Ala?Ala?Glu?Val?Ala?Ala?Thr?Glu?Ile?1???????????????5??????????????????l0??????????????????15Lys?Met?Glu?Glu?Glu?Ser?Gly?Ala?Pro?Gly?Val?Pro?Ser?Gly?Asn?Gly

20??????????????????25??????????????????30Ala?Pro?Gly?Pro?Lys?Gly?Glu?Gly?Glu?Arg?Pro?Ala?Gln?Asn?Glu?Lys

35??????????????????40??????????????????45Arg?Lys?Glu?Lys?Asn?Ile?Lys?Arg?Gly?Gly?Asn?Arg?Phe?Glu?Pro?Tyr

50??????????????????55??????????????????60Ala?Asn?Pro?Thr?Lys?Arg?Tyr?Arg?Ala?Phe?Ile?Thr?Asn?Ile?Pro?Phe65??????????????????70??????????????????75??????????????????80Asp?Val?Lys?Trp?Gln?Ser?Leu?Lys?Asp?Leu?Val?Lys?Glu?Lys?Val?Gly

85??????????????????90??????????????????95Glu?Val?Thr?Tyr?Val?Glu?Leu?Leu?Met?Asp?Ala?Glu?Gly?Lys?Ser?Arg

100?????????????????105?????????????????110Gly?Cys?Ala?Val?Val?Glu?Phe?Lys?Met?Glu?Glu?Ser?Met?Lys?Lys?Ala

115?????????????????120?????????????????125Ala?Glu?Val?Leu?Asn?Lys?His?Ser?Leu?Ser?Gly?Arg?Pro?Leu?Lys?Val

130?????????????????135?????????????????140Lys?Glu?Asp?Pro?Asp?Gly?Glu?His?Ala?Arg?Arg?Ala?Met?Gln?Lys?Ala145?????????????????150?????????????????155?????????????????160Gly?Arg?Leu?Gly?Ser?Thr?Val?Phe?Val?Ala?Asn?Leu?Asp?Tyr?Lys?Val

165?????????????????170?????????????????175Gly

<210>203

<211>164

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>203Met?Arg?Leu?Ala?Val?Gly?Ala?Leu?Leu?Val?Cys?Ala?Val?Leu?Gly?Leu?1???????????????5??????????????????10??????????????????15Cys?Leu?Ala?Val?Pro?Asp?Lys?Thr?Val?Arg?Trp?Cys?Ala?Val?Ser?Glu

20??????????????????25??????????????????30His?Glu?Ala?Thr?Lys?Cys?Gln?Ser?Phe?Arg?Asp?His?Met?Lys?Ser?Val

35??????????????????40??????????????????45Ile?Pro?Ser?Asp?Gly?Pro?Ser?Val?Ala?Cys?Val?Lys?Lys?Ala?Ser?Tyr

50??????????????????55??????????????????60Leu?Asp?Cys?Ile?Arg?Ala?Ile?Ala?Ala?Asn?Glu?Ala?Asp?Ala?Val?Thr65??????????????????70??????????????????75??????????????????80Leu?Asp?Ala?Gly?Leu?Val?Tyr?Asp?Ala?Tyr?Leu?Ala?Pro?Asn?Asn?Leu

85??????????????????90??????????????????95Lys?Pro?Val?Val?Ala?Glu?Phe?Tyr?Gly?Ser?Lys?Glu?Asp?Pro?Gln?Thr

100?????????????????105?????????????????110Phe?Tyr?Tyr?Ala?Val?Ala?Val?Val?Lys?Lys?Asp?Ser?Gly?Phe?Gln?Met

115?????????????????120?????????????????125Asn?Gln?Leu?Arg?Gly?Lys?Lys?Ser?Cys?His?Thr?Gly?Leu?Gly?Arg?Ser

130?????????????????135?????????????????140Ala?Gly?Trp?Asn?Ile?Pro?Ile?Gly?Leu?Leu?Tyr?Cys?Asp?Leu?Pro?Glu145?????????????????150?????????????????155?????????????????160Pro?Arg?Lys?Pro

<210>204

<211>241

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>204Met?Ser?Gly?Glu?Ser?Ala?Arg?Ser?Leu?Gly?Lys?Gly?Ser?Ala?Pro?Pro?1???????????????5??????????????????10??????????????????15Gly?Pro?Val?Pro?Glu?Gly?Ser?Ile?Arg?Ile?Tyr?Ser?Met?Arg?Phe?Cys

20??????????????????25??????????????????30Pro?Phe?Ala?Glu?Arg?Thr?Arg?Leu?Val?Leu?Lys?Ala?Lys?Gly?Ile?Arg

35??????????????????40??????????????????45His?Glu?Val?Ile?Asn?Ile?Asn?Leu?Lys?Asn?Lys?Pro?Glu?Trp?Phe?Phe

50??????????????????55??????????????????60Lys?Lys?Asn?Pro?Phe?Gly?Leu?Val?Pro?Val?Leu?Glu?Asn?Ser?Gln?Gly65??????????????????70??????????????????75??????????????????80Gln?Leu?Ile?Tyr?Glu?Ser?Ala?Ile?Thr?Cys?Glu?Tyr?Leu?Asp?Glu?Ala

85??????????????????90??????????????????95Tyr?Pro?Gly?Lys?Lys?Leu?Leu?Pro?Asp?Asp?Pro?Tyr?Glu?Lys?Ala?Cys

100?????????????????105?????????????????110Gln?Lys?Met?Ile?Leu?Glu?Leu?Phe?Ser?Lys?Val?Pro?Ser?Leu?Val?Gly

115?????????????????120?????????????????125Ser?Phe?Ile?Arg?Ser?Gln?Asn?Lys?Glu?Asp?Tyr?Asp?Gly?Leu?Lys?Glu

130?????????????????135?????????????????140Glu?Phe?Arg?Lys?Glu?Phe?Thr?Lys?Leu?Glu?Glu?Val?Leu?Thr?Asn?Lys145?????????????????150?????????????????155?????????????????160Lys?Thr?Thr?Phe?Phe?Gly?Gly?Asn?Ser?Ile?Ser?Met?Ile?Asp?Tyr?Leu

165?????????????????170?????????????????175Ile?Trp?Pro?Trp?Phe?Glu?Arg?Leu?Glu?Ala?Met?Lys?Leu?Asn?Glu?Cys

180?????????????????185?????????????????190Val?Asp?His?Thr?Pro?Lys?Leu?Lys?Leu?Trp?Met?Ala?Ala?Met?Lys?Glu

195?????????????????200?????????????????205Asp?Pro?Thr?Val?Ser?Ala?Leu?Leu?Thr?Ser?Glu?Lys?Asp?Trp?Gln?Gly

210?????????????????215?????????????????220Phe?Leu?Glu?Leu?Tyr?Leu?Gln?Asn?Ser?Pro?Glu?Ala?Cys?Asp?Tyr?Gly225?????????????????230?????????????????235?????????????????240Leu

<210>205

<211>160

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>205Met?Gln?Ile?Phe?Val?Lys?Thr?Leu?Thr?Gly?Lys?Thr?Ile?Thr?Leu?Glu?1???????????????5??????????????????10??????????????????15Val?Glu?Pro?Ser?Asp?Thr?Ile?Glu?Asn?Val?Lys?Ala?Lys?Ile?Gln?Asp

20??????????????????25??????????????????30Lys?Glu?Gly?Ile?Pro?Pro?Asp?Gln?Gln?Arg?Leu?Ile?Phe?Ala?Gly?Lys

35??????????????????40??????????????????45Gln?Leu?Glu?Asp?Gly?Arg?Thr?Leu?Ser?Asp?Tyr?Asn?Ile?Gln?Lys?Glu

50??????????????????55??????????????????60Ser?Thr?Leu?His?Leu?Val?Leu?Arg?Leu?Arg?Gly?Gly?Met?Gln?Ile?Phe65??????????????????70??????????????????75??????????????????80Val?Lys?Thr?Leu?Thr?Gly?Lys?Thr?Ile?Thr?Leu?Glu?Val?Glu?Pro?Ser

85??????????????????90??????????????????95Asp?Thr?Ile?Glu?Asn?Val?Lys?Ala?Lys?Ile?Gln?Asp?Lys?Glu?Gly?Ile

100?????????????????105?????????????????110Pro?Pro?Asp?Gln?Gln?Arg?Leu?Ile?Phe?Ala?Gly?Lys?Gln?Leu?Glu?Asp

115?????????????????120?????????????????125Gly?Arg?Thr?Leu?Ser?Asp?Tyr?Asn?Ile?Gln?Lys?Glu?Ser?Thr?Leu?His

130?????????????????135?????????????????140Leu?Val?Leu?Arg?Leu?Arg?Gly?Gly?Met?Gln?Ile?Phe?Val?Lys?Thr?Leu145?????????????????150?????????????????155?????????????????160

<210>206

<211>197

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>206Thr?Ser?Pro?Ser?Glu?Ala?Cys?Ala?Pro?Leu?Leu?Ile?Ser?Leu?Ser?Thr?1???????????????5??????????????????10??????????????????15Leu?Ile?Tyr?Asn?Gly?Ala?Leu?Pro?Cys?Gln?Cys?Asn?Pro?Gln?Gly?Ser

20??????????????????25??????????????????30Leu?Ser?Ser?Glu?Cys?Asn?Pro?His?Gly?Gly?Gln?Cys?Leu?Cys?Lys?Pro

35??????????????????40??????????????????45Gly?Val?Val?Gly?Arg?Arg?Cys?Asp?Leu?Cys?Ala?Pro?Gly?Tyr?Tyr?Gly

50??????????????????55??????????????????60Phe?Gly?Pro?Thr?Gly?Cys?Gln?Gly?Ala?Cys?Leu?Gly?Cys?Arg?Asp?His65??????????????????70??????????????????75??????????????????80Thr?Gly?Gly?Glu?His?Cys?Glu?Arg?Cys?Ile?Ala?Gly?Phe?His?Gly?Asp

85??????????????????90??????????????????95Pro?Arg?Leu?Pro?Tyr?Gly?Gly?Gln?Cys?Arg?Pro?Cys?Pro?Cys?Pro?Glu

100?????????????????105?????????????????110Gly?Pro?Gly?Ser?Gln?Arg?His?Phe?Ala?Thr?Ser?Cys?His?Gln?Asp?Glu

115?????????????????120?????????????????125Tyr?Ser?Gln?Gln?Ile?Val?Cys?His?Cys?Arg?Ala?Gly?Tyr?Thr?Gly?Leu

130?????????????????135?????????????????140Arg?Cys?Glu?Ala?Cys?Ala?Pro?Gly?His?Phe?Gly?Asp?Pro?Ser?Arg?Pro145?????????????????150?????????????????155?????????????????160Gly?Gly?Arg?Cys?Gln?Leu?Cys?Glu?Cys?Ser?Gly?Asn?Ile?Asp?Pro?Met

165?????????????????170?????????????????175Asp?Pro?Asp?Ala?Cys?Asp?Pro?His?Thr?Gly?Gln?Cys?Leu?Arg?Cys?Leu

180?????????????????185?????????????????190His?His?Thr?Glu?Gly

195

<210>207

<211>175

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>207Ile?Ile?Arg?Gln?Gln?Gly?Leu?Ala?Ser?Tyr?Asp?Tyr?Val?Arg?Arg?Arg?1???????????????5??????????????????10??????????????????15Leu?Thr?Ala?Glu?Asp?Leu?Phe?Glu?Ala?Arg?Ile?Ile?Ser?Leu?Glu?Thr

20??????????????????25??????????????????30Tyr?Asn?Leu?Leu?Arg?Glu?Gly?Thr?Arg?Ser?Leu?Arg?Glu?Ala?Leu?Glu

35??????????????????40??????????????????45Ala?Glu?Ser?Ala?Trp?Cys?Tyr?Leu?Tyr?Gly?Thr?Gly?Ser?Val?Ala?Gly

50??????????????????55??????????????????60Val?Tyr?Leu?Pro?Gly?Ser?Arg?Gln?Thr?Leu?Ser?Ile?Tyr?Gln?Ala?Leu65??????????????????70??????????????????75??????????????????80Lys?Lys?Gly?Leu?Leu?Ser?Ala?Glu?Val?Ala?Arg?Leu?Leu?Leu?Glu?Ala

85??????????????????90??????????????????95Gln?Ala?Ala?Thr?Gly?Phe?Leu?Leu?Asp?Pro?Val?Lys?Gly?Glu?Arg?Leu

100?????????????????105?????????????????110Thr?Val?Asp?Glu?Ala?Val?Arg?Lys?Gly?Leu?Val?Gly?Pro?Glu?Leu?His

115?????????????????120?????????????????125Asp?Arg?Leu?Leu?Ser?Ala?Glu?Arg?Ala?Val?Thr?Gly?Tyr?Arg?Asp?Pro

130?????????????????135?????????????????140Tyr?Thr?Glu?Gln?Thr?Ile?Ser?Leu?Phe?Gln?Ala?Met?Lys?Lys?Glu?Leu145?????????????????150?????????????????155?????????????????160Ile?Pro?Thr?Glu?Glu?Ala?Leu?Arg?Leu?Trp?Met?Pro?Ser?Trp?Pro

165?????????????????170?????????????????175

<210>208

<211>177

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>208Met?Ala?Ala?Gly?Val?Glu?Ala?Ala?Ala?Glu?Val?Ala?Ala?Thr?Glu?Ile?1???????????????5??????????????????10??????????????????15Lys?Met?Glu?Glu?Glu?Ser?Gly?Ala?Pro?Gly?Val?Pro?Ser?Gly?Asn?Gly

20??????????????????25??????????????????30Ala?Pro?Gly?Pro?Lys?Gly?Glu?Gly?Glu?Arg?Pro?Ala?Gln?Asn?Glu?Lys

35??????????????????40??????????????????45Arg?Lys?Glu?Lys?Asn?Ile?Lys?Arg?Gly?Gly?Asn?Arg?Phe?Glu?Pro?Tyr

50??????????????????55??????????????????60Ala?Asn?Pro?Thr?Lys?Arg?Tyr?Arg?Ala?Phe?Ile?Thr?Asn?Ile?Pro?Phe65??????????????????70??????????????????75??????????????????80Asp?Val?Lys?Trp?Gln?Ser?Leu?Lys?Asp?Leu?Val?Lys?Glu?Lys?Val?Gly

85??????????????????90??????????????????95Glu?Val?Thr?Tyr?Val?Glu?Leu?Leu?Met?Asp?Ala?Glu?Gly?Lys?Ser?Arg

100?????????????????105?????????????????110Gly?Cys?Ala?Val?Val?Glu?Phe?Lys?Met?Glu?Glu?Ser?Met?Lys?Lys?Ala

115?????????????????120?????????????????125Ala?Glu?Val?Leu?Asn?Lys?His?Ser?Leu?Ser?Gly?Arg?Pro?Leu?Lys?Val

130?????????????????135?????????????????140Lys?Glu?Asp?Pro?Asp?Gly?Glu?His?Ala?Arg?Arg?Ala?Met?Gln?Lys?Val145?????????????????150?????????????????155?????????????????160Met?Ala?Thr?Thr?Gly?Gly?Met?Gly?Met?Gly?Pro?Gly?Gly?Pro?Gly?Met

165?????????????????170?????????????????175Ile

<210>209

<211>196

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>209Asp?Leu?Gln?Asp?Met?Phe?Ile?Val?His?Thr?Ile?Glu?Glu?Ile?Glu?Gly?1???????????????5??????????????????10??????????????????15Leu?Ile?Ser?Ala?His?Asp?Gln?Phe?Lys?Ser?Thr?Leu?Pro?Asp?Ala?Asp

20??????????????????25??????????????????30Arg?Glu?Arg?Glu?Ala?Ile?Leu?Ala?Ile?His?Lys?Glu?Ala?Gln?Arg?Ile

35??????????????????40??????????????????45Ala?Glu?Ser?Asn?His?Ile?Lys?Leu?Ser?Gly?Ser?Asn?Pro?Tyr?Thr?Thr

50??????????????????55??????????????????60Val?Thr?Pro?Gln?Ile?Ile?Asn?Ser?Lys?Trp?Glu?Lys?Val?Gln?Gln?Leu65??????????????????70??????????????????75??????????????????80Val?Pro?Lys?Arg?Asp?His?Ala?Leu?Leu?Glu?Glu?Gln?Ser?Lys?Gln?Gln

85??????????????????90??????????????????95Ser?Asn?Glu?His?Leu?Arg?Arg?Gln?Phe?Ala?Ser?Gln?Ala?Asn?Val?Val

100?????????????????105?????????????????110Gly?Pro?Trp?Ile?Gln?Thr?Lys?Met?Glu?Glu?Ile?Gly?Arg?Ile?Ser?Ile

115?????????????????120?????????????????125Glu?Met?Asn?Gly?Thr?Leu?Glu?Asp?Gln?Leu?Ser?His?Leu?Lys?Gln?Tyr

130?????????????????135?????????????????140Glu?Arg?Ser?Ile?Val?Asp?Tyr?Lys?Pro?Asn?Leu?Asp?Leu?Leu?Glu?Gln145?????????????????150?????????????????155?????????????????160Gln?His?Gln?Leu?Ile?Gln?Glu?Ala?Leu?Ile?Phe?Asp?Asn?Lys?His?Thr

165?????????????????170?????????????????175Asn?Tyr?Thr?Met?Glu?His?Ile?Arg?Val?Gly?Trp?Glu?Gln?Leu?Leu?Thr

180?????????????????185?????????????????190Thr?Ile?Ala?Arg

195

<210>210

<211>156

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>210Lys?Leu?Thr?Ile?Glu?Ser?Thr?Pro?Phe?Asn?Val?Ala?Glu?Gly?Lys?Glu?1???????????????5??????????????????10??????????????????15Val?Leu?Leu?Leu?Ala?His?Asn?Leu?Pro?Gln?Asn?Arg?Ile?Gly?Tyr?Ser

20??????????????????25??????????????????30Trp?Tyr?Lys?Gly?Glu?Arg?Val?Asp?Gly?Asn?Ser?Leu?Ile?Val?Gly?Tyr

35??????????????????40??????????????????45Val?Ile?Gly?Thr?Gln?Gln?Ala?Thr?Pro?Gly?Pro?Ala?Tyr?Ser?Gly?Arg

50??????????????????55??????????????????60Glu?Thr?Ile?Tyr?Pro?Asn?Ala?Ser?Leu?Leu?Ile?Gln?Asn?Val?Thr?Gln65??????????????????70??????????????????75??????????????????80Asn?Asp?Thr?Gly?Phe?Tyr?Thr?Leu?Gln?Val?Ile?Lys?Ser?Asp?Leu?Val

85??????????????????90??????????????????95Asn?Glu?Glu?Ala?Thr?Gly?Gln?Phe?His?Val?Tyr?Pro?Glu?Leu?Pro?Lys

100?????????????????105?????????????????110Pro?Ser?Ile?Ser?Ser?Asn?Asn?Ser?Asn?Pro?Val?Glu?Asp?Lys?Asp?Ala

115??????????????????120??????????????????125Val?Ala?Phe?Thr?Cys?Glu?Pro?Glu?Val?Gln?Asn?Thr?Thr?Tyr?Leu?Trp

130?????????????????135?????????????????140Trp?Val?Asn?Gly?Gln?Ser?Leu?Pro?Val?Ser?Pro?Lys145?????????????????150?????????????????155

<210>211

<211>92

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>211Met?Glu?Ser?Pro?Ser?Ala?Pro?Pro?His?Arg?Trp?Cys?Ile?Pro?Trp?Gln?1???????????????5??????????????????10??????????????????15Arg?Leu?Leu?Leu?Thr?Ala?Ser?Leu?Leu?Thr?Phe?Trp?Asn?Pro?Pro?Thr

20??????????????????25??????????????????30Thr?Ala?Lys?Leu?Thr?Ile?Glu?Ser?Thr?Pro?Phe?Asn?Val?Ala?Glu?Gly

35??????????????????40??????????????????45Lys?Glu?Val?Leu?Leu?Leu?Val?His?Asn?Leu?Pro?Gln?His?Leu?Phe?Gly

50??????????????????55??????????????????60Tyr?Ser?Trp?Tyr?Lys?Gly?Glu?Arg?Val?Asp?Gly?Asn?Arg?Gln?Ile?Ile65??????????????????70??????????????????75??????????????????80Gly?Tyr?Val?Ile?Gly?Thr?Gln?Gln?Ala?Thr?Pro?Gly

85??????????????????90

<210>212

<211>142

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>212Glu?Lys?Gln?Lys?Asn?Lys?Glu?Phe?Ser?Gln?Thr?Leu?Glu?Asn?Glu?Lys?1???????????????5??????????????????10??????????????????15Asn?Thr?Leu?Leu?Ser?Gln?Ile?Ser?Thr?Lys?Asp?Gly?Glu?Leu?Lys?Met

20??????????????????25??????????????????30Leu?Gln?Glu?Glu?Val?Thr?Lys?Met?Asn?Leu?Leu?Asn?Gln?Gln?Ile?Gln

35??????????????????40??????????????????45Glu?Glu?Leu?Ser?Arg?Val?Thr?Lys?Leu?Lys?Glu?Thr?Ala?Glu?Glu?Glu

50??????????????????55??????????????????60Lys?Asp?Asp?Leu?Glu?Glu?Arg?Leu?Met?Asn?Gln?Leu?Ala?Glu?Leu?Asn65??????????????????70??????????????????75??????????????????80Gly?Ser?Ile?Gly?Asn?Tyr?Cys?Gln?Asp?Val?Thr?Asp?Ala?Gln?Ile?Lys

85??????????????????90??????????????????95Asn?Glu?Leu?Leu?Glu?Ser?Glu?Met?Lys?Asn?Leu?Lys?Lys?Cys?Val?Ser

100?????????????????105?????????????????110Glu?Leu?Glu?Glu?Glu?Lys?Gln?Gln?Leu?Val?Lys?Glu?Lys?Thr?Lys?Val

115?????????????????120?????????????????125Glu?Ser?Glu?Ile?Arg?Lys?Glu?Tyr?Leu?Glu?Lys?Ile?Gln?Gly

130?????????????????135?????????????????140

<210>213

<211>142

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>213Gly?Gly?Tyr?Gly?Gly?Gly?Tyr?Gly?Gly?Val?Leu?Thr?Ala?Ser?Asp?Gly?1???????????????5??????????????????10??????????????????15Leu?Leu?Ala?Gly?Asn?Glu?Lys?Leu?Thr?Met?Gln?Asn?Leu?Asn?Asp?Arg

20??????????????????25??????????????????30Leu?Ala?Ser?Tyr?Leu?Asp?Lys?Val?Arg?Ala?Leu?Glu?Ala?Ala?Asn?Gly

35??????????????????40??????????????????45Glu?Leu?Glu?Val?Lys?Ile?Arg?Asp?Trp?Tyr?Gln?Lys?Gln?Gly?Pro?Gly

50??????????????????55??????????????????60Pro?Ser?Arg?Asp?Tyr?Ser?His?Tyr?Tyr?Thr?Thr?Ile?Gln?Asp?Leu?Arg65??????????????????70??????????????????75??????????????????80Asp?Lys?Ile?Leu?Gly?Ala?Thr?Ile?Glu?Asn?Ser?Arg?Ile?Val?Leu?Gln

85??????????????????90??????????????????95Ile?Asp?Asn?Ala?Arg?Leu?Ala?Ala?Asp?Asp?Phe?Arg?Thr?Lys?Phe?Glu

100?????????????????105?????????????????110Thr?Glu?Gln?Ala?Leu?Arg?Met?Ser?Val?Glu?Ala?Asp?Ile?Asn?Gly?Leu

115?????????????????120?????????????????125Arg?Arg?Val?Leu?Asp?Glu?Leu?Thr?Leu?Ala?Arg?Thr?Asp?Leu

130?????????????????135?????????????????140

<210>214

<211>129

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>214Val?Met?Arg?Val?Asp?Phe?Asn?Val?Pro?Met?Lys?Asn?Asn?Gln?Ile?Thr?1???????????????5??????????????????10??????????????????15Asn?Asn?Gln?Arg?Ile?Lys?Ala?Ala?Val?Pro?Ser?Ile?Lys?Phe?Cys?Leu

20??????????????????25??????????????????30Asp?Asn?Gly?Ala?Lys?Ser?Val?Val?Leu?Met?Ser?His?Leu?Gly?Arg?Pro

35??????????????????40??????????????????45Asp?Gly?Val?Pro?Met?Pro?Asp?Lys?Tyr?Ser?Leu?Glu?Pro?Val?Ala?Val

50???????????????????55?????????????????60Glu?Leu?Arg?Ser?Leu?Leu?Gly?Lys?Asp?Val?Leu?Phe?Leu?Lys?Asp?Cys65??????????????????70??????????????????75??????????????????80Val?Gly?Pro?Glu?Val?Glu?Lys?Ala?Cys?Ala?Asn?Pro?Ala?Ala?Gly?Ser

85??????????????????90??????????????????95Val?Ile?Leu?Leu?Glu?Asn?Leu?Arg?Phe?His?Val?Glu?Glu?Glu?Gly?Lys

100?????????????????105?????????????????110Gly?Lys?Asp?Ala?Ser?Gly?Asn?Lys?Val?Lys?Ala?Glu?Pro?Ala?Lys?Ile

115?????????????????120?????????????????125Glu

<210>215

<211>148

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>215Met?Ala?Thr?Leu?Lys?Glu?Lys?Leu?Ile?Ala?Pro?Val?Ala?Glu?Glu?Glu?1???????????????5??????????????????10??????????????????15Ala?Thr?Val?Pro?Asn?Asn?Lys?Ile?Thr?Val?Val?Gly?Val?Gly?Gln?Val

20??????????????????25??????????????????30Gly?Met?Ala?Cys?Ala?Ile?Ser?Ile?Leu?Gly?Lys?Ser?Leu?Ala?Asp?Glu

35??????????????????40??????????????????45Leu?Ala?Leu?Val?Asp?Val?Leu?Glu?Asp?Lys?Leu?Lys?Gly?Glu?Met?Met

50??????????????????55??????????????????60Asp?Leu?Gln?His?Gly?Ser?Leu?Phe?Leu?Gln?Thr?Pro?Lys?Ile?Val?Ala65??????????????????70??????????????????75??????????????????80Asp?Lys?Asp?Tyr?Ser?Val?Thr?Ala?Asn?Ser?Lys?Ile?Val?Val?Val?Thr

85??????????????????90??????????????????95Ala?Gly?Val?Arg?Gln?Gln?Glu?Gly?Glu?Ser?Arg?Leu?Asn?Leu?Val?Gln

100?????????????????105?????????????????110Arg?Asn?Val?Asn?Val?Phe?Lys?Phe?Ile?Ile?Pro?Gln?Ile?Val?Lys?Tyr

115?????????????????120?????????????????125Ser?Pro?Asp?Cys?Ile?Ile?Ile?Val?Val?Ser?Asn?Pro?Val?Asp?Ile?Leu

130?????????????????135?????????????????140Thr?Tyr?Val?Thr145

<210>216

<211>527

<212>PRT

＜213〉homo sapiens (Homo sapiens)

<400>216Gln?Arg?Ala?Pro?Gly?Ile?Glu?Glu?Lys?Ala?Ala?Glu?Asn?Gly?Ala?Leu?1???????????????5??????????????????10??????????????????15Gly?Ser?Pro?Glu?Arg?Glu?Glu?Lys?Val?Leu?Glu?Asn?Gly?Glu?Leu?Thr

20??????????????????25??????????????????30Pro?Pro?Arg?Arg?Glu?Glu?Lys?Ala?Leu?Glu?Asn?Gly?Glu?Leu?Arg?Ser

35??????????????????40??????????????????45Pro?Glu?Ala?Gly?Glu?Lys?Val?Leu?Val?Asn?Gly?Gly?Leu?Thr?Pro?Pro

50??????????????????55??????????????????60Lys?Ser?Glu?Asp?Lys?Val?Ser?Glu?Asn?Gly?Gly?Leu?Arg?Phe?Pro?Arg65??????????????????70??????????????????75??????????????????80Asn?Thr?Glu?Arg?Pro?Pro?Glu?Thr?Gly?Pro?Trp?Arg?Ala?Pro?Gly?Pro

85??????????????????90??????????????????95Trp?Glu?Lys?Thr?Pro?Glu?Ser?Trp?Gly?Pro?Ala?Pro?Thr?Ile?Gly?Glu

100?????????????????105?????????????????110Pro?Ala?Pro?Glu?Thr?Ser?Leu?Glu?Arg?Ala?Pro?Ala?Pro?Ser?Ala?Val

115?????????????????120?????????????????125Val?Ser?Ser?Arg?Asn?Gly?Gly?Glu?Thr?Ala?Pro?Gly?Pro?Leu?Gly?Pro

130?????????????????135?????????????????140Ala?Pro?Lys?Asn?Gly?Thr?Leu?Glu?Pro?Gly?Thr?Glu?Arg?Arg?Ala?Pro145?????????????????150?????????????????155?????????????????160Glu?Thr?Gly?Gly?Ala?Pro?Arg?Ala?Pro?Gly?Ala?Gly?Arg?Leu?Asp?Leu

165?????????????????170?????????????????175Gly?Ser?Gly?Gly?Arg?Ala?Pro?Val?Gly?Thr?Gly?Thr?Ala?Pro?Gly?Gly

180?????????????????185?????????????????190Gly?Pro?Gly?Ser?Gly?Val?Asp?Ala?Lys?Ala?Gly?Trp?Val?Asp?Asn?Thr

195?????????????????200?????????????????205Arg?Pro?Gln?Pro?Pro?Pro?Pro?Pro?Leu?Pro?Pro?Pro?Pro?Glu?Ala?Gln

210?????????????????215?????????????????220Pro?Arg?Arg?Leu?Glu?Pro?Ala?Pro?Pro?Arg?Ala?Arg?Pro?Glu?Val?Ala225?????????????????230?????????????????235?????????????????240Pro?Glu?Gly?Glu?Pro?Gly?Ala?Pro?Asp?Ser?Arg?Ala?Gly?Gly?Asp?Thr

245?????????????????250?????????????????255Ala?Leu?Ser?Gly?Asp?Gly?Asp?Pro?Pro?Lys?Pro?Glu?Arg?Lys?Gly?Pro

260?????????????????265?????????????????270Glu?Met?Pro?Arg?Leu?Phe?Leu?Asp?Leu?Gly?Pro?Pro?Gln?Gly?Asn?Ser

275?????????????????280?????????????????285Glu?Gln?Ile?Lys?Ala?Arg?Leu?Ser?Arg?Leu?Ser?Leu?Ala?Leu?Pro?Pro

290?????????????????295?????????????????300Leu?Thr?Leu?Thr?Pro?Phe?Pro?Gly?Pro?Gly?Pro?Arg?Arg?Pro?Pro?Trp305?????????????????310?????????????????315?????????????????320Glu?Gly?Ala?Asp?Ala?Gly?Ala?Ala?Gly?Gly?Glu?Ala?Gly?Gly?Ala?Gly

325?????????????????330?????????????????335Ala?Pro?Gly?Pro?Ala?Glu?Glu?Asp?Gly?Glu?Asp?Glu?Asp?Glu?Asp?Glu

340?????????????????345?????????????????350Glu?Glu?Asp?Glu?Glu?Ala?Ala?Ala?Pro?Gly?Ala?Ala?Ala?Gly?Pro?Arg

355?????????????????360?????????????????365Gly?Pro?Gly?Arg?Ala?Arg?Ala?Ala?Pro?Val?Pro?Val?Val?Val?Ser?Ser

370?????????????????375?????????????????380Ala?Asp?Ala?Asp?Ala?Ala?Arg?Pro?Leu?Arg?Gly?Leu?Leu?Lys?Ser?Pro385?????????????????390?????????????????395?????????????????400Arg?Gly?Ala?Asp?Glu?Pro?Glu?Asp?Ser?Glu?Leu?Glu?Arg?Lys?Arg?Lys

405?????????????????410?????????????????415Met?Val?Ser?Phe?His?Gly?Asp?Val?Thr?Val?Tyr?Leu?Phe?Asp?Gln?Glu

420?????????????????425?????????????????430Thr?Pro?Thr?Asn?Glu?Leu?Ser?Val?Gln?Ala?Pro?Pro?Glu?Gly?Asp?Thr

435?????????????????440?????????????????445Asp?Pro?Ser?Thr?Pro?Pro?Ala?Pro?Pro?Thr?Pro?Pro?His?Pro?Ala?Thr

450?????????????????455?????????????????460Pro?Gly?Asp?Gly?Phe?Pro?Ser?Asn?Asp?Ser?Gly?Phe?Gly?Gly?Ser?Phe465?????????????????470?????????????????475?????????????????480Glu?Trp?Ala?Glu?Asp?Phe?Pro?Leu?Leu?Pro?Pro?Pro?Gly?Pro?Pro?Leu

485?????????????????490?????????????????495Cys?Phe?Ser?Arg?Phe?Ser?Val?Ser?Pro?Ala?Leu?Glu?Thr?Pro?Gly?Pro

500?????????????????505?????????????????510Pro?Ala?Arg?Ala?Pro?Asp?Ala?Arg?Pro?Ala?Gly?Pro?Val?Glu?Asn

515?????????????????520?????????????????525

<210>217

<211>466

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>217gaatggtgcc?tgtcctgctg?tctctgctgc?tgcttctggg?tcctgctgtc?ccccaggaga?????60accaagatgg?tcgttactct?ctgacctata?tctacactgg?gctgtccaag?catgttgaag????120acgtccccgc?gtttcaggcc?cttggctcac?tcaatgacct?ccagttcttt?agatacaaca????180gtaaagacag?gaagtctcag?cccatgggac?tctggagaca?ggtggaagga?atggaggatt????240ggaagcagga?cagccaactt?cagaaggcca?gggaggacat?ctttatggag?accctgaaag????300acatcgtgga?gtattacaac?gacagtaacg?ggtctcacgt?attgcaggga?aggtttggtt????360gtgagatcga?gaataacaga?agcagcggag?cattctggaa?atattactat?gatggaaagg????420actacattga?attcaacaaa?gaaatcccag?cctgggtccc?cttcga???????????????????466

<210>218

<211>381

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>218gagtttcctt?cgcaagttca?tgtggggtac?cttcccaggc?tgcctggctg?accagctggt?????60tttaaagcgc?cggggtaacc?agttggagat?ctgtgccgtg?gtcctgaggc?agttgtctcc????120acacaagtac?tacttcctcg?tgggctacag?tgaaactttg?ctgtcctact?tttacaaatg????180tcctgtgcga?ctccacctcc?aaactgtgcc?ctcaaaggtt?gtgtataagt?acctctagaa????240caatcccctt?ttttccatca?agctgtagcc?tgcagagaat?ggaaacgtgg?gaaaggaatg????300gtatgtgggg?gaaatgcatc?ccctcagagg?actgaggcat?agtctctcat?ctgctattga????360ataaagacct?tctatcttgt?a??????????????????????????????????????????????381

<210>219

<211>1293

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>219gaggggaggc?gcatggcggg?gatggcgctg?gcgcgggcct?ggaagcagat?gtcctggttc??????60tactaccagt?acctgctggt?cacggcgctc?tacatgctgg?agccctggga?gcggacggtg?????120ttcaattcca?tgctggtttc?cattgtgggg?atggcactat?acacaggata?cgtcttcatg?????180ccccagcaca?tcatggcgat?attgcactac?tttgaaatcg?tacaatgacc?aagatgcgac?????240caggatcaga?ggttccttgg?ggaagaccca?ccctacgaag?ttggaatgag?accatcagat?????300gtgataagaa?actcttctag?atgtcaacat?aaccaacctt?ataaagacta?aaattcatga?????360gtagaacagg?aaaatcatcc?tgactcatgt?gttgtgttct?ttatttttaa?ttttcaaaga?????420ggctcttgta?tagcagtttt?tgtctatttt?aacattgtag?tcatttgtac?tttgatatca?????480gtattttctt?aacctttgtg?actgtttcaa?tattaccccc?gtgaaagctt?ttcttaatgt?????540aactttgagt?acattttaat?tgccttctat?ttttaaaact?caaaatcatt?agttgggctt?????600tactgttctt?gctattgtat?ggcatataca?tctgcctgga?tatatttcta?ctcttgacca?????660aagttttgta?aagaacaata?taagatttcg?ggtaggggta?tggggaggga?agatatttta?????720ttgagaacta?cttaacaaaa?gatttatctg?taagcttgaa?ctcaggagta?cagttttagc?????780tatctagact?ctaacagctt?ttgctttaaa?attattaaag?tgtttcttaa?tgaaaaagaa?????840aagatcttgc?taaagttaaa?ataaggaaca?tttcaccttt?taaatattta?attcttatgt?????900ggacttattt?ccagaaaact?ttggtgataa?ttcttgagac?aaaaggtggt?taagtagcat?????960tattatgtaa?tgcttatata?ccatagagtt?tttaatagaa?gagaaatcca?tttcctccga????1020gggtcactat?taacaatgta?cttccttaaa?tttagtttaa?tgattgtaat?gggtgctgca????1080tttgcacatt?gcattaagtt?atgatgagac?gaattgttgt?taaaaattat?agcaaaaaga????1140aatgtaaact?tggttaaaat?cctttcactc?tttgtattgt?tttttttaag?gtttttattc????1200cttaaatgta?aaatgactac?ctaatttttt?gatgtaaata?cattaaattc?aaagagaaaa????1260aaaatcaaaa?aaaaaaaaaa?aaaaaaactc?gag?????????????????????????????????1293

<210>220

<211>983

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>220caggttattc?tgatcctgcc?gcctgtcttc?cctgtaagag?tggagcctcg?aggtgtacct?????60taaagtgacc?ggaatgttag?agatgcaatt?tgcagagctg?gggcaaggaa?gggctccttg????120tcactgtagt?tactttcctt?gcagtggcca?aatgcccaat?aagaaggaat?acatgaccac????180tgctgtgggg?agtcagcagg?tgcgtgatgc?agctggccac?actccatcca?cggccatgac????240ataaaacaga?caagaagtaa?ggctggactg?taacacctca?aggcctgctc?cagtgaccca????300ctttcttcag?agaggctcta?ccacacacac?aaccaccttc?caaatttaca?ctcagatcac????360tacaccatgt?ctcccaagtt?aaaacatgta?tccacctaga?ctttaaatgt?gctttgtaac????420tgttgatggc?actgtacaga?gggccaaagt?atttcccatc?agatagcatt?tttctgaacc????480catgcctctt?gggacgagat?cacaggactt?gacccatcat?caaataggac?caggtgacct????540acagagacat?cacaatgatg?gcttcctaca?gtcaagtcca?tttccaataa?tgctctcatc????600taagagaacc?catgaacctt?atttgaatcc?tggttcaaac?aaaaacctta?aattatttat????660gagacaatta?taaacttgat?agattttgat?gtgtgaaggt?atttatgaat?atttttagtc????720agtgatggta?tactgttaag?gaaaaggttc?atattttagg?gacaaaggct?gaaacattta????780tggacagagt?gatatgatat?ctgggatttg?ttttaggatg?aagtgggagg?gaggaaatga????840atggaaatag?tgttgaaaca?gtattggcca?cgagtcagct?attgtgtgct?aagacgctcc????900tcacaccagt?ctactctgta?tgtgtttgaa?tatctctgta?ataaacttaa?caaggaaaaa????960aaaaaaaaaa?aaaaaaactc?gag????????????????????????????????????????????983

<210>221

<211>373

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>221cattttatgg?gttaattttt?tattaaatag?caataagata?cttttataac?tcaataaaat?????60tattcaatga?tacattcgga?aaataaatgt?ataaaatatg?aaaaagtact?aaaaagcatt????120tttcagtact?tttaggtaag?attaatccaa?ctaaacacta?gcatatgtta?tacagtaata????180ataaggggaa?aatacaataa?tgttgagaaa?gcaaactcaa?agcatagatc?aatgaaaaaa????240ttgagaaatg?gacataaatg?atttagtatt?tttaaagaga?gtgaaaaatc?attattttat????300gcttttgtgt?agcgttagat?gaattaaata?acatatgcac?atatagcttt?gcgatacaaa????360tttccagacc?ata???????????????????????????????????????????????????????373

<210>222

<211>544

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>222cagagatgct?gctgctacaa?aggatcggtg?taagcagtta?acccaggaaa?tgatgacaga?????60gaaagaaaga?agcaatgtgg?ttataacaag?gatgaaagat?cgaattggaa?cattagaaaa????120ggaacataat?gtatttcaaa?acaaaataca?tgtcagttat?caagagactc?aacagatgca????180gatgaagttt?cagcaagttc?gtgagcagat?ggaggcagag?atagctcact?tgaagcagga????240aaatggtata?ctgagagatg?cagtcagcaa?cactacaaat?caactggaaa?gcaagcagtc????300tgcagaacta?aataaactac?gccaggatta?tgctaggttg?gtgaatgagc?tgactgagaa????360aacaggaaag?ctacagcaag?aggaagtcca?aaagaagaat?gctgagcaag?cagctactca????420gttgaaggtt?caactacaag?aagctgagag?aaggtgggaa?gaagttcaga?gctacatcag????480gaagagaaca?gcggaacatg?aggcagcaca?gctagattta?cagagtaaat?ttgtggccaa????540agaa?????????????????????????????????????????????????????????????????544

<210>223

<211>316

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>223gaggcaaggg?atatgcttta?gtgcctatta?tagttaattc?ttcaactcca?aagtctaaaa?????60cagttgaatc?tgctgaagga?aaatctgaag?aagtaaatga?aacattagtt?atacccactg????120aggaagcaga?aatggaagaa?agtggacgaa?gtgcaactcc?tgttaactgt?gaacagcctg????180atatcttggt?ttcttctaca?ccaataaatg?aaggacagac?tgtgttagac?aaggtggctg????240agcagtgtga?acctgctgaa?agtcagccag?aagcacttct?gagaggaaga?tgtttgcaag????300gtaactctaa?cagttg????????????????????????????????????????????????????316

<210>224

<211>1583

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>224cagaccacgt?ctgccctcgc?cgctctagcc?ctgcgcccca?gcccggccgc?ggcacctccg??????60cctcgccgcc?gctaggtcgg?ccggctccgc?ccggctgccg?cctaggatga?atatcatgga?????120cttcaacgtg?aagaagctgg?cggccgacgc?aggcaccttc?ctcagtcgcg?ccgtgcagtt?????180cacagaagaa?aagcttggcc?aggctgagaa?gacagaattg?gatgctcact?tagagaacct?????240ccttagcaaa?gctgaatgta?ccaaaatatg?gacagaaaaa?ataatgaaac?aaactgaagt?????300gttattgcag?ccaaatccaa?atgccaggat?agaagaattt?gtttatgaga?aactggatag?????360aaaagctcca?agtcgtataa?acaacccaga?acttttggga?caatatatga?ttgatgcagg?????420gactgagttt?ggcccaggaa?cagcttatgg?taatgccctt?attaaatgtg?gagaaaccca?????480aaaaagaatt?ggaacagcag?acagagaact?gattcaaacg?tcagccttaa?attttcttac?????540tcctttaaga?aactttatag?aaggagatta?caaaacaatt?gctaaagaaa?ggaaactatt?????600gcaaaataag?agactggatt?tggatgctgc?aaaaacgaga?ctaaaaaagg?caaaagctgc?????660agaaactaga?aattcatctg?aacaggaatt?aagaataact?caaagtgaat?ttgatcgtca?????720agcagagatt?accagacttc?tgctagaggg?aatcagcagt?acacatgccc?atcaccttcg?????780ctgtctgaat?gactttgtag?aagcccagat?gacttactat?gcacagtgtt?accagtatat?????840gttggacctc?cagaaacaac?tgggaagttt?tccatccaat?tatcttagta?acaacaatca?????900gacttctgtg?acacctgtac?catcagtttt?accaaatgcg?attggttctt?ctgccatggc?????960ttcaacaagt?ggcctagtaa?tcacctctcc?ttccaacctc?agtgacctta?aggagtgtag????1020tggcagcaga?aaggccaggg?ttctctatga?ttatgatgca?gcaaacagta?ctgaattatc????1080acttctggca?gatgaggtga?tcactgtgtt?cagtgttgtt?ggaatggatt?cagactggct????1140aatgggggaa?aggggaaacc?agaagggcaa?ggtgccaatt?acctacttag?aactgctcaa????1200ttaagtaggt?ggactatgga?aaggttgccc?atcatgactt?tgtatttata?tacaattaac????1260tctaaataaa?gcaggttaag?tatcttccat?gttaatgtgt?taagagactg?aaaataccag????1320ccatcagaaa?ctggcctttt?tgccaataaa?gttgcatggt?aaatatttca?ttacagaatt????1380tatgttagag?ctttcatgcc?aagaatgttt?tcttacaaaa?ttctcttttt?attgaggttt????1440cactaataag?cagcttctac?ttttgagcct?caacttaaag?cagaactgtt?ttttactgga????1500tttttcatta?acagcaagct?ttttttttta?tgtaaaataa?atctattgtg?aattgaaaaa????1560aaaaaaaaaa?aaaaaaactc?gag????????????????????????????????????????????1583

<210>225

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>225gaacaacatc?atcttgaatc?actagataga?ctcttgacgg?aaagcaaagg?ggaaatgaaa?????60aaggaaaata?tgaagaaaga?tgaagcttta?aaagcattac?agaaccaagt?atctgaagaa????120acaatcaagg?ttaggcaact?agattcagca?ttggaaattt?gtaaggaaga?acttgtcttg????180catttgaatc?aattggaagg?aaataaggaa?aagtttgaaa?aacagttaaa?gaagaaatct????240gaagaggtat?attgtttaca?gaaagagcta?aagataaaaa?atcacagtct?tcaagagact????300tctgagcaaa?acgttattct?acagcatact?cttcagcaac?agcagcaaat?gttacaacaa????360gagacaatta?gaaatggaga?gctagaagat?actcaaacta?aacttgaaaa?acaggtgtca????420aaactggaac?aagaacttca?aaaacaaagg?gaaagttcag?ctgaaaagtt?gagaaaaatg????480gaggagaaat?g?????????????????????????????????????????????????????????491

<210>226

<211>483

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>226cagccgcacg?ccgcggagca?ggggctcgga?ggtcccggga?ttacggtgct?cgagcacgct?????60ggtgggaaag?gacccgggac?ttgaacagtg?ttgtgcggcg?ccatgcaggt?ctccagcctc????120aatgaggtga?agatttacag?cctcagctgc?ggcaagtccc?ttcctgagtg?gctttctgat????180aggaagaaga?gagcgctaca?gaagaaagat?gtagatgtcc?gtaggagaat?tgaacttatt????240caggactttg?aaatgcctac?tgtgtgtacc?actattaagg?tgtcaaaaga?tggacagtac????300attttagcaa?ctggaacata?taaacctcgg?gttcgatgtt?atgacaccta?tcaattatcc????360ttgaagtttg?aaaggtgttt?agattcagaa?gttgtcacct?ttgaaatttt?gtctgatgac????420tactcaaaga?ttgtcttctt?acataatgat?agatacattg?aatttcattc?gcaatcaggt????480ttt??????????????????????????????????????????????????????????????????483

<210>227

<211>486

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>227gagcctcgct?aagctccgac?tctgggcggc?accgggcgtc?ccacgatgcc?gaagaacaag?????60aagcggaaca?ctccccaccg?cggtagcagt?gctggcggcg?gcgggtcagg?agcagccgca????120gcgacggcgg?cgacagcagg?tggccagcat?cgaaatgttc?agccttttag?tgatgaagat????180gcatcaattg?aaacagtgag?ccattgcagt?ggttatagcg?atccttccag?ttttgctgaa????240gatggaccag?aagtccttga?tgaggaagga?actcaagaag?acctagagta?caagttgaag????300ggattaattg?acctaaccct?ggataagagt?gcgaagacaa?ggcaagcagc?tcttgaaggt????360attaaaaatg?cactggcttc?aaaaatgctg?tatgaattta?ttctggaaag?gagaatgact????420ttaactgata?gcattgaacg?ctgcctgaaa?aaaggtaaga?gtgatgagca?acgtgcagct????480gcagcg???????????????????????????????????????????????????????????????486

<210>228

<211>494

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>228gaggccagga?ctccgggaat?gcgagcaggc?cccttattct?cccagtggcc?tcggtctgtc?????60cccacagcgg?cccggtcagg?gttgcccgag?ccccaaggcg?gggggcggca?ccggggtgct????120gaaagggaca?gaatgctttg?acctccaagc?tgttttaaat?ctagtagata?agccagatcc????180tgtgttgcca?taagcccttg?gcccacattt?aagtgggaat?gcagctagct?tggatgtctg????240aaactttgta?agcgccttct?gtctgaatcc?tgaacacagg?caccaagact?actgaagaag????300ctcgtcattc?ttgtgcaggg?atagccacac?aagcaaacat?gtttgcaaaa?cttgaaagaa????360agaaaattgc?agaaagaaga?cttgctgttc?ttaagaggcc?caggaaggtg?ctacttagga????420atcccaccgg?cttgtgaagc?aagggaatca?agtttgcctt?caatggggaa?cttgacttca????480ggaaaatgaa?cttt??????????????????????????????????????????????????????494

<210>229

<211>465

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>229gtcagagagc?tggtataacc?tcctgttgga?catgcagaac?cgactcaata?aggtcatcaa?????60aagcgtgggc?aagattgagc?actccttctg?gagatccttt?cacactgagc?gaaagacaga????120accagccaca?ggcttcatcg?atggtgatct?gattgaaagt?ttcctagata?tcagccgccc????180taagatgcag?gaggttgtgg?caaacttgca?gtatgatgat?ggcagtggta?tgaagcggga????240ggcaactgca?gatgacctca?tcaaagtcgt?ggaggaacta?actcggatcc?attagccaag????300gacaggatct?cttttcctga?ccctcctaaa?ggcgttgccc?tcctatcctc?ccttccttgc????360ccacccttgg?tttctttggc?atgggaaggt?tttccttaac?cacttgccct?agagccacca????420gtgaccttgt?gtggaaacag?ggtttttttt?acttaaaaca?gttca????????????????????465

<210>230

<211>495

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>230caggggaaag?ggtgtttggc?cttgaccagc?cactgctgac?ctcaatctca?gacctacaga?????60tggtgaatat?ctccctgcga?gtgttgtctc?gacccaatgc?tcaggagctt?cctagcatgt????120accagcgcct?agggctggac?tacgaggaac?gagtgttgcc?gtccattgtc?aacgaggtgc????180tcaagagtgt?ggtggccaag?ttcaatgcct?cacagctgat?cacccagcgg?gcccaggtat????240ccctgttgat?ccgccgggag?ctgacagaaa?gggccaaagg?acttcagcct?catcctggat????300gatgtggcca?tcacagactt?gagctttagc?cgagaagtac?acaagctgcc?tgtaagaaac????360ccaaccaagt?ggggtgaatt?ccaaaaaccc?gtgggggtga?agggcttctt?aagaatgcaa????420ggaaggagga?aaagaattcc?atgggggggg?ggttccttaa?cccaggaaca?ggggtttccc????480ttgaattttt?ttcca?????????????????????????????????????????????????????495

<210>231

<211>498

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>231ggcagcttct?gagaccaggg?ttgctccgtc?cgtgctccgc?ctcgccatga?cttcctacag?????60ctatcgccag?tcgtcggcca?cgtcgtcctt?cggaggcctg?ggcggcggct?ccgtgcgttt????120tgggccgggg?gtcgcttttc?gcgcgcccag?cattcacggg?ggctccggcg?gccgcggcgt????180atccgtgtcc?tccgcccgct?ttgtgtcctc?gtcctcctcg?gggggctacg?gcggcggcta????240cggcggcgtc?ctgaccgcgt?ccgacgggct?gctggcgggc?aacgagaagc?taaccatgca????300gaacctcaac?gaccgcctgc?ctcctacctg?gacaaagtgc?gcgccctgga?agcgggcaac????360ggcgaactta?gaggtgaaag?aatcccgcga?actggtacca?aaaacaaggg?gcctggggcc????420ttccgcgact?tacagccaac?ttactacacc?gaacattcaa?gaacttgcgg?gaacaaaaat????480ttttggtgcc?acccattt??????????????????????????????????????????????????498

<210>232

<211>465

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>232caggccggcc?gagtaggaaa?gctggaggcg?cgggtgggga?acatgtctga?gtcggagctc?????60ggcaggaagt?gggaccggtg?tctggcggat?gcggtcgtga?agataggtac?tggttttgga????120ttaggaattg?ttttctcact?taccttcttt?aaaagaagaa?tgtggccatt?agccttcggt????180tctggcatgg?gattaggaat?ggcttattcc?aactgtcagc?atgatttcca?ggctccatat????240cttctacatg?gaaaatatgt?caaagagcag?gagcagtgac?ttcacctgag?aacatcccag????300cgggaggaca?agagaaaatc?atgtttattc?ctcaggaata?cttgaagtgc?cctggagtaa????360actgccattc?ttctgtaaca?atggtatcag?taatgcttta?aactccagca?cctggttatg????420catttgaaac?ccaagtctgg?ttcttggttt?ggattttctc?tctgg????????????????????465

<210>233

<211>366

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(366)

＜223〉n=A, T, C or G

<400>233cagtaaaaaa?ggttatgttt?tattaattgc?tggacaaccg?tgggaaaaca?aataagcaat?????60tgacaccacc?aaattcttat?tacattcaan?ataaaanatt?tattcacacc?acaaaaagat????120aatcacaaca?aaatatacac?taacttaaaa?aacaaaagat?tatagtgaca?taaaatgtta????180tattctcttt?ttaagtgggt?aaaagtattt?tgtttgcttc?tacataaatt?tctattcatg????240ananaataac?aaatattaaa?atacagtgat?agtttgcatt?tcttctatag?aatgaacata????300gacataaccc?tgaagctttt?agtttacagg?gagtttccat?gaagccacaa?actaaactaa????360ttatca???????????????????????????????????????????????????????????????366

<210>234

<211>379

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>234gagggcagcc?ctcctacctg?cgcacgtggt?gccgccgctg?ctgcctcccg?ctcgccctga?????60acccagtgcc?tgcagccatg?gctcccggcc?agctcgcctt?atttagtgtc?tctgacaaaa????120ccggccttgt?ggaatttgca?agaaacctga?ccgctcttgg?tttgaatctg?gtcgcttccg????180gagggactgc?aaaagctctc?agggatgctg?gtctggcagt?cacagatgtc?tctgagttga????240cgggatttct?gaaatgttgg?ggggacgtgt?gaaaactttg?catcctgcac?gatcccatgc????300tggaatccta?gctcctaata?ttcagaagat?aatgcttgac?atgcgccaca?cttgattcaa????360tcttataaca?attgttgcc?????????????????????????????????????????????????379

<210>235

<211>406

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>235caggctgcac?catgtacccc?accttcagtt?taaaagaaaa?aaaaaatccc?cttcactcct?????60actgggaggt?gggacccctt?tcattttcag?ttttgctcat?ctagggaaaa?taaggctttg????120gtttccagtt?taattgtttt?tgaccttcta?aaatgttttt?atgttagcac?tgatagttgg????180cattactgtt?gttaagcact?gtgttccaga?ccgtgtctga?cttagtgtaa?cctaggagat????240tttatagttt?tattttaatg?aaaccctgat?tgacgcacag?cagtggggag?aacagcgtct????300tttacctgtc?accgaagcca?ggaagccccg?tttgtaagcg?tgtgttgtgg?tgctttattg????360tacatcctcc?agtggcgttc?tttttactct?aatgttcttt?tggttt???????????????????406

<210>236

<211>278

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>236gagattagca?cctgtgaaca?atgcgttctc?tgatgacact?ctgagcatgg?accaacgcct?????60tcttaagcta?attctgcaaa?atcacatatt?gaaagtaaaa?gttggcctta?gcgacctcta????120caatggacag?atactggaaa?ccattggagg?caaacaactc?cgagtctttg?tgtatcggac????180ggctatctgc?atagaaaact?catgcatggt?gagaggaagc?aagcagggaa?ggaacggtgc????240cattcacata?ttccgagaga?tcatccaacc?agcagaat????????????????????????????278

<210>237

<211>322

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400> 237 cagggccgtg gcggaggagg agcgctgcac ggtggagcgt cgggccgacc tcacctacgc 60 ggagttcgtg cagcagtacg tgcgcccctg atcgcggagg tcgcgtcctg ttcaccggcc 120 cgtctgcccc gaccgcccaa ggccgccttc ccctgacctc gcgcgcacgc gtggggctgg 180 ggcggcgagg ctggcggtcc ggcctggccg cgactctgcc cttctttcca gaggttccgg 240 gccctgtgct cccgcgacag gttgctggct tcgtttgggg acagagtggt ccggtgagca 300 ccgccaacac ctactcctac ct 322 <210> 238 <211> 613 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (399) <223> n = A, T, C or G <400> 238 gaattcggca ccagccttct tggatcagga ccagtctcca ccccgtttct acagtggaga 60 tcagcctcct tcttatcttg gtgcaagtgt ggataaactc catcaccctt tagaatttgc 120 agacaaatct cccacacctc ctaatttacc tagcgataaa atctaccctc cttctgggtc 180 ccccgaagag aataccagca cagccaccat gacttacatg acaactactc cagcaacagc 240 ccaaatgagc accaaggaag ccagctggga tgtggctgaa caacccacca ctgctgattt 300 tgctgctgcc acacttcagc gcacgcacag aactaatcgt ccccttcccc ctccgccttc 360 ccagagatct gcagagcagc caccagttgt ggggcaggna caagcagcaa ccaatatagg 420 attaaataat tcccacaagg ttcaaggagt agttccagtt ccagagaggc cacctgaacc 480 tcgagccatg gatgaccctg cgtctgcctt catcagtgac agtggtgctg ctgctgctca 540 gtgtcccatg gctacagctg tccagccagg cctgcctgag aaagtgcggg acggtgcccg 600 ggtcccgctg ctg 613 <210> 239 <211> 613 <212> DNA <213> Homo (Homo sapiens) <400> 239 gaattcggca ccaggggaca ctggtgctga gctggatgat gatcagcact ggtctgacag 60 cccgtcggat gctgacagag agctgcgttt gccgtgccca gctgaggggg aagcagagct 120 ggagctgagg gtgtcggaag atgaggagaa gctgcccgcc tcaccgaagc accaagagag 180 aggtccctcc caagccacca gccccatccg gtctccccag gaatcagctc ttctgttcat 240 tccagtccac agcccctcaa cagaggggcc ccaactccca cctgtccctg ccgccaccca 300 ggagaaatca cctgaggagc gccttttccc tgagcctttg ctccccaaag agaagcccaa 360 agctgatgcc ccctcggatc tgaaagctgt gcactctccc atccgatcac agccagtgac 420 cctgccagaa gctaggactc ctgtctcacc agggagcccg cagccccagc cacccgtggc 480 ggcctccacg cccccaccca gcgaggtctc cagagccttc tctctcctgt gcaaaatggc 540 aactcttaag gaaaaactca ttgcaccagt tgcggaagaa gaggcaacag ttccaaacaa 600 taagatcact gta 613 <210> 240 <211> 585 <212> DNA <213> Homo (Homo sapiens) <400> 240 gaattcggca cgaggtgaga tctacgatga actttaagat tggaggtgtg acagaacgca 60 tgccaacccc agttattaaa gcttttggca tcttgaagcg agcggccgct gaagtaaacc 120 aggattatgg tcttgatcca aagattgcta atgcaataat gaaggcagca gatgaggtag 180 ctgaaggtaa attaaatgat cattttcctc tcgtggtatg gcagactgga tcaggaactc 240 agacaaatat gaatgtaaat gaagtcatta gcaatagagc aattgaaatg ttaggaggtg 300 aacttggcag caagatacct gtgcatccca acgatcatgt taataaaagc cagagctcaa 360 atgatacttt tcccacagca atgcacattg ctgctgcaat agaagttcat gaagtactgt 420 taccaggact acagaagtta catgatgctc ttgatgcaaa atccaaagag tttgcacaga 480 tcatcaagat tggacgtact catactcagg atgctgttcc acttactctt gggcaggaat 540 ttagtggtta tgttcaacaa gtaaaatatg caatgacaag aataa 585 <210> 241 <211> 566 <212> DNA <213> Homo (Homo sapiens) <400> 241 gaattcggca ccaggcgagc tgcacctcga ggtgaaggcc tcactgatga acgatgactt 60 cgagaagatc aagaactggc agaaggaagc ctttcacaag cagatgatgg gcggcttcaa 120 ggagaccaag gaagctgagg acggctttcg gaaggcacag aagccctggg ccaagaagct 180 gaaagaggta gaagcagcaa agaaagccca ccatgcagcg tgcaaagagg agaagctggc 240 tatctcacga gaagccaaca gcaaggcaga cccatccctc aaccctgaac agctcaagaa 300 attgcaagac aaaatagaaa agtgcaagca agatgttctt aagaccaaag agaagtatga 360 gaagtccctg aaggaactcg accagggcac accccagtac atggagaaca tggagcaggt 420 gtttgagcag tgccagcagt tcgaggagaa acgccttcgc ttcttccggg aggttctgct 480 ggaggttcag aagcacctag acctgtccaa tgtggctggc tacaaagcca tttaccatga 540 cctggagcag agcatcagag cagctg 566 <210> 242 <211> 556 <212> DNA <213> Homo (Homo sapiens) <400> 242 gaattcggca cgagcaaagg tgaagcagga catgcctccg cccgggggct atgggcccat 60 cgactacaaa cggaacttgc cgcgtcgagg actgtcgggc tacagcatgc tggccatagg 120 gattggaacc ctgatctacg ggcactggag cataatgaag tggaaccgtg agcgcaggcg 180 cctacaaatc gaggacttcg aggctcgcat cgcgctgttg ccactgttac aggcagaaac 240 cgaccggagg accttgcaga tgcttcggga gaacctggag gaggaggcca tcatcatgaa 300 ggacgtgccc gactggaagg tgggggagtc tgtgttccac acaacccgct gggtgccccc 360 cttgatcggg gagctgtacg ggctgcgcac cacagaggag gctctccatg ccagccacgg 420 cttcatgtgg tacacgtagg ccctgtgccc tccggccacc tggatccctg cccctcccca 480 ctgggacgga ataaatgctc tgcagacctg gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 540 aaaaaaaaaa ctcgag 556 <210> 243 <211> 591 <212> DNA <213> Homo (Homo sapiens) <400> 243 gtctatgttt gcagaaatac agatccaaga caaagacagg atgggcactg ctggaaaagt 60 tattaaatgc aaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat 120 agaagttgcc ccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg 180 tcgcacagat gaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg 240 acatgaggca actgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg 300 tgacaaagtc atccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc 360 agatggcaac ctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac 420 caccagattt acatgcaagg gcaaaccagt ccaccacttc atgaacacca gtacatttac 480 cgagtacaca gtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga 540 gaaagtctgt ttaattggct gtgggttttc cactggatat ggcgctgctg t 591 <210> 244 <211> 594 <212> DNA <213> Homo (Homo sapiens) <400> 244 gaattcggca cgagaacaga gtgaactgag catcagtcag aaaaagtcta tgtttgcaga 60 aatacagatc caagacaaag acaggatggg cactgctgga aaagttatta aatgcaaagc 120 agctgtgctt tgggagcaga agcaaccctt ctccattgag gaaatagaag ttgccccacc 180 aaagactaaa gaagttcgca ttaagatttt ggccacagga atctgtcgca cagatgacca 240 tgtgataaaa ggaacaatgg tgtccaagtt tccagtgatt gtgggacatg aggcaactgg 300 gattgtagag agcattggag aaggagtgac tacagtgaaa ccaggtgaca aagtcatccc 360 tctctttctg ccacaatgta gagaatgcaa tgcttgtcgc aacccagatg gcaacctttg 420 cattaggagc gatattactg gtcgtggagt actggctgat ggcaccacca gatttacatg 480 caagggcaaa ccagtccacc acttcatgaa caccagtaca tttaccgagt acacagtggt 540 ggatgaatct tctgttgcta agattgatga tgcagctcct cctgagaaag tctg 594 <210> 245 <211> 615 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (105) <223> n = A, T, C or G <400> 245 gtccctttcc tctgctgccg ctcggtcacg cttgtgcccg aaggaggaaa cagtgacaga 60 cctggagact gcagttctct atccttccac agctctttca ccatnctgga tcacttcctt 120 tgaatgcaga agcttgctgg ccaaaagatg tgggaattgt tgcccttgag atctattttc 180 cttctcaata tgttgatcaa gcagagttgg aaaaatatga tggtgtagat gctggaaagt 240 ataccattgg cttgggccag gccaagatgg gcttctgcac agatagagaa gatattaact 300 ctctttgcat gactgtggtt cagaatctta tggagagaaa taacctttcc tatgattgca 360 ttgggcggct ggaagttgga acagagacaa tcatcgacaa atcaaagtct gtgaagacta 420 atttgatgca gctgtttgaa gagtctggga atacagatat agaaggaatc gacacaacta 480 atgcatgcta tggaggcaca gctgctgtct tcaatgcttg ttaactggat tgagtccagc 540 tcttgggatg gacggtatgc cctggtaagt tgcaggagat attgctgtat atgccacagg 600 aaatgctaga cctac 615 <210> 246 <211> 546 <212> DNA <213> Homo (Homo sapiens) <400> 246 gaattcggca ccaggctgcc tcccgctcgc cctgaaccca gtgcctgcag ccatggctcc 60 cggccagctc gccttattta gtgtctctgc aaaaccggcc ttgtgaattt gcaagaaacc 120 tgaccgctct tggtttgaat ctggtcgctt ccggagggac tgcaaaagct ctcagggatg 180 ctggtctggc agtcagagat gtctctgagt tgacgggatt tcctgaaatg ttggggggac 240 gtgtgaaaac tttgcatcct gcagtccatg ctggaatcct agctcgtaat attccagaag 300 ataatgctga catggccaga cttgatttca atcttataag agttgttgcc tgcaatctct 360 atccctttgt aaagacagtg gcttctccag gtgtaactgt tgaggaggct gtggagcaaa 420 ttgacattgg tggagtaacc ttactgagag ctgcagccaa aaaccacgct cgagtgacag 480 tggtgtgtga accagaggac tatgtgggtg ggtgtccacg gagatgcaga gctccgagag 540 taagga 546 <210> 247 <211> 564 <212> DNA <213> Homo (Homo sapiens) <400> 247 gaattcggca ccagagatca cgtgcagtga gatgcagcaa aaagttgaac ttctgagata 60 tgaatctgaa aagcttcaac aggaaaattc tattttgaga aatgaaatta ctactttaaa 120 tgaagaagat agcatttcta acctgaaatt agggacatta aatggatctc aggaagaaat 180 gtggcaaaaa acggaaactg taaaacaaga aaatgctgca gttcagaaga tggttgaaaa 240 tttaaagaaa cagatttcag aattaaaaat caaaaaccaa caattggatt tggaaaatac 300 agaacttagc caaaagaact ctcaaaacca ggaaaaactg caagaactta atcaacgtct 360 aacagaaatg ctatgccaga aggaaaaaga gccaggaaac agtgcattgg aggaacggga 420 acaagagaag tttaatctga aagaagaact ggaacgttgt aaagtgcagt cctccacttt 480 agtgtcttct ctggaggcgg agctctctga agttaaaata cagacccata ttgtgcaaca 540 ggaaaaccac cttctcaaag atga 564 <210> 248 <211> 434 <212> DNA <213> Homo (Homo sapiens) <400> 248 gttcttgttt gtggatcgct gtgatcgtca cttgacaatg cagatcttcg tgaagactct 60 gactggtaag accatcaccc tcgaggttga gcccagtgac accatcgaga atgtcaaggc 120 aaagatccaa gataaggaag gcatccctcc tgaccagcag aggctgatct ttgctggaaa 180 acagctggaa gatgggcgca ccctgtctga ctacaacatc cagaaagagt ccaccctgca 240 cctggtgctc cgtctcagag gtgggatgca aatcttcgtg aagacactca ctggcaagac 300 catcaccctt gaggtggagc ccagtgacac catcgagaac gtcaaagcaa agatccagga 360 caaggaaggc attcctcctg accagcagag gttgatcttt gccggaaagc cagcctggga 420 agatggggcc gcca 434 <210> 249 <211> 416 <212> DNA <213> Homo (Homo sapiens) <400> 249 gcgggcccag gaggcggcgg cggcggcggc ggacgggccc cccgcggcag acggcgagga 60 cggacaggac ccgcacagca agcacctgta cacggccgac atgttcacgc acgggatcca 120 gagcgccgcg cacttcgtca tgttcttcgc gccctggtgt ggacactgcc agcggctgca 180 gccgacttgg aatgacctgg gagacaaata caacagcatg gaagatgcca aagtctatgt 240 ggctaaagtg gactgcacgg cccactccga cgtgtgctcc gcccaggggg tgcgaggata 300 ccccacctta aagcttttca agccaggcca agaagctgtg aagtaccagg gtcctcggga 360 cttccagaca ctggaaaact ggatgctgca gacactgaac gaggagccag tgacac 416 <210> 250 <211> 504 <212> DNA <213> Homo (Homo sapiens) <400> 250 gaattcggca cgaggcgggt aacgttatag tatttgtcag aagttggggt ctccgtgggc 60 attgtgatcc gtcccaggca gtggattagg aggccagaag gagatccctt ccacggtgct 120 aggctgagat ggatcctctc agggcccaac agctggctgc ggagctggag gtggagatga 180 tggccgatat gtacaacaga atgaccagtg cctgccaccg gaagtgtgtg cctcctcact 240 acaaggaagc agagctctcc aagggcgagt ctgtgtgcct ggaccgatgt gtctctaagt 300 acctggacat ccatgagcgg atgggcaaaa agttgacaga gttgtctatg caggatgaag 360 agctgatgaa gagggtgcag cagagctctg ggcctgcatg aggtccctgt cagtatacac 420 cctggggtgt accccacccc ttcccacttt aataaacgtg ctccctgttg ggtgtcatct 480 gtgaagactg ccaggcctag ctct 504 <210> 251 <211> 607 <212> DNA <213> Homo (Homo sapiens) <400> 251 gatgaaaata cacaatttta ctagcaaatg cctctactgt aatcgctatt tacccacaga 60 tactctgctc aaccatatgt taattcatgg tctgtcttgt ccatattgcc gttcaacttt 120 caatgatgtg gaaaagatgg ccgcacacat gcggatggtt cacattgatg aagagatggg 180 acctaaaaca gattctactt tgagttttga tttgacattg cagcagggta gtcacactaa 240 catccatctc ctggtaacta catacaatct gagggatgcc ccagctgaat ctgttgctta 300 ccatgcccaa aataatcctc cagttcctcc aaagccacag ccaaaggttc aggaaaaggc 360 agatatccct gtaaaaagtt cacctcaagc tgcagtgccc tataaaaaag atgttgggaa 420 aaccctttgt cctctttgct tttcaatcct aaaaggaccc atatctgatg cacttgcaca 480 tcacttacga gagaggcacc aagttattca gacggttcat ccagttgaga aaaagctcac 540 ctacaaatgt atccattgcc ttggtgtgta taccagcaac atgaccgcct caactatcac 600 tctgcat 607 <210> 252 <211> 618 <212> DNA <213> Homo (Homo sapiens) <400> 252 gaattcgcac caggggtcct gctggtcttc gcctttcttc tccgcttcta ccccgtcggc 60 cgctgccact ggggtccctg gccccaccga catggcggcg gtgttgagca agtcctggag 120 cgcacggagc tgaacaagct gcccaagtct gtccagaaca aacttgaaaa gttccttgct 180 gatcagcaat ccgagatcga tggcctgaag gggcggcatg agaaatttaa ggtggagagc 240 gaacaacagt attttgaaat agaaaagagg ttgtcccaca gtcaggagag acttgtgaat 300 gaaacccgag agtgtcaaag cttgcggctt gagctagaga aactcaacaa tcaactgaag 360 gcactaactg agaaaaacaa agaacttgaa attgctcagg atcgcaatat tgccattcag 420 agccaattta caagaacaaa ggaagaatta gaagctgaga aaagagactt aattagaacc 480 aatgagagac tatctcaaga acttgaatac ttaacagagg atgttaaacg tctgaatgaa 540 aaacttaaag aaagcaatac aacaaagggt gaacttcagt taaaattgga tgaacttcaa 600 gcttctgatg tttctgtt 618 <210> 253 <211> 1201 <212> DNA <213> Homo (Homo sapiens) <400> 253 gaattcggca ccagggtggc gagcgcggct gctgtgctgg ggcgagcagc ggggaccgtg 60 tgtgagtttg gcatgatttg gtcccctggg attctgcctt agcaagaaag aagttggaaa 120 tacttcctgg aagaaaacta aaacaataca aaagccacag cttattgatt gcatgtcagc 180 ccccttacaa atatggacac atttcctagc ctatttccac ctggaggaga tagtaggctg 240 aatcctgagc ctgagttcca aaatatgtta attgatgaaa gggtacgctg tgaacatcat 300 aaacataatt atcaggctct gaaaattgaa cacaaaaggt tgcaggaaga atatgtaaaa 360 tcacaaaatg aacttaaacg tgtattaatt gaaaagcaag caagccagga aaaattccaa 420 ctgctccttg aagacttaag gggagaatta gtagagaaag ctagagacat agaaaaaatg 480 aaactgcagg tactaacacc acaaaaattg gaattggtaa aagcccaact acaacaagaa 540 ttagaagctc caatgcgaga acgttttcgg actcttgatg aagaagtgga aaggtacaga 600 gctgagtata acaagctgcg ctacgagtat acatttctca agtcagagtt tgaacaccag 660 aaagaagagt ttactcgggt ttcagaagaa gagaaaatga aatacaagtc agaggttgca 720 cgactggaga aggacaaaga ggagctacat aaccagctgc ttagtgttga tcccacgaga 780 gacagcaaac gaatggagca acttgttcga gaaaaaaccc atttgcttca gaaattgaaa 840 agtttagagg ctgaagtagc agaattaagg gctgagaaag aaaattctgg tgctcaggta 900 gaaaatgtcc aaagaataca ggtgaggcag ttggctgaga tgcaggctac actcagatcc 960 ttggaggctg aaaagcagtc agctaaacta caagctgagc gtttagaaaa agaactacaa 1020 tcaagcaatg aacagaatac ctgcttaatc agcaaactgc atagagctga ccgagaaatc 1080 agcacactgg ccagtgaagt gaaagagctt aaacatgcaa acaaactaga aataactgac 1140 atcaaactgg aggcagcaag agctaagagt gagctcgaaa gagaaaggaa taagatccaa 1200 a 1201 <210> 254 <211> 560 <212> DNA <213> Homo (Homo sapiens) <400> 254 gaattcggca ccagtttggg gggtgaggtt taattggaaa tggtctctgg ggactgaaaa 60 ctgatgtttt tgcagattac ctcagggaaa cggaggtttg ttgagttaca gacacattaa 120 accaaaggcc gtgggaaaac ccctctccag ctccagggga ttggtcagga ccacccacta 180 accagtgcct tccttcttaa cattcacttt tagcagcttg tgtttatttt acatgggcag 240 ttttgatggg aaattgccat gaccacaggg gtttggagtt ctgctttttt tttttcttct 300 tctttttcgg gggactgggg gactcctccc aagatcacat tttagcatct ttctctccta 360 ctccatttag aaaaataagt aacaggtgaa atgtggtctc agtgttaacg ggataattct 420 gctaccggct cctccctgat gattctgaaa tacactactg aacgagctct ggctggtcct 480 ttctatcctg gatgtggttc ttctgtgtag caattccttg atgtccagtt tggaaagatg 540 tactcttctc aacaagaaaa 560 <210> 255 <211> 612 <212> DNA <213> Homo (Homo sapiens) <400> 255 gaattcggca ccaggcgggg cagcagggcc gcggccatgg ggagcttgaa ggaggagctg 60 ctcaaagcca tctggcacgc cttcaccgac tcgaccagga ccacagggca aggtctccaa 120 gtcccagctc aaggtccttt cccataacct gtgcacggtg ctgaaggttc ctcatgaccc 180 agttgccctt gaagagcact tcagggatga tgatgagggt ccagtgtcca accagggcta 240 catgccttat ttaaacaggt tcattttgga aaaggtccaa gacaactttg acaagattga 300 attcaatagg atgtgttgga ccctctgtgt caaaaaaaaa cctcacaaag aatcccctgc 360 tcattacaga agaagatgca tttaaaatat gggttatttt caacttttta tctgaggaca 420 agtatccatt aattattgtg tcagaagaga ttgaatacct gcttaagaag cttacagaag 480 ctatgggagg aggttggcag caagaacaat ttgaacatta taaaatcaac tttgatgaca 540 gtaaaaatgg cctttctgca tgggaactta ttgagcttat tggaaatgga cagtttagca 600 aaggcatgga cc 612 <210> 256 <211> 1132 <212> DNA <213> Homo (Homo sapiens) <400> 256 gaattcggca cgaggtctgg gagaggcctc tggagcagga ggcccagtgg ctcttctgac 60 ccaaggcccc gccgtccagc ttctaagtgc cagatgatgg aggagcgtgc caacctgatg 120 cacatgatga aactcagcat caaggtgttg ctccagtcgg ctctgagcct gggccgcagc 180 ctggatgcgg accatgcccc cttgcagcag ttctttgtag tgatggagca ctgcctcaaa 240 catgggctga aagttaagaa gagttttatt ggccaaaata aatcattctt tggtcctttg 300 gagctggtgg agaaactttg tccagaagca tcagatatag cgactagtgt cagaaatctt 360 ccagaattaa agacagctgt gggaagaggc cgagcgtggc tttatcttgc actcatgcaa 420 aagaaactgg cagattatct gaaagtgctt atagacaata aacatctctt aagcgagttc 480 tatgagcctg aggctttaat gatggaggaa gaagggatgg tgattgttgg tctgctggtg 540 ggactcaatg ttctcgatgc caatctctgc ttgaaaggag aagacttgga ttctcaggtt 600 ggagtaatag atttttccct ctaccttaag gatgtgcagg atcttgatgg tggcaaggag 660 catgaaagaa ttactgatgt ccttgatcaa aaaaattatg tggaagaact taaccggcac 720 ttgagctgca cagttgggga tcttcaaacc aagatagatg gcttggaaaa gactaactca 780 aagcttcaag aagagctttc agctgcaaca gaccgaattt gctcacttca agaagaacag 840 cagcagttaa gagaacaaaa tgaattaatt cgagaaagaa gtgaaaagag tgtagagata 900 acaaaacagg ataccaaagt tgagctggag acttacaagc aaactcggca aggtctggat 960 gaaatgtaca gtgatgtgtg gaagcagcta aaagaggaga agaaagtccg gttggaactg 1020 gaaaaagaac tggagttaca aattggaatg aaaaccgaaa tggaaattgc aatgaagtta 1080 ctggaaaagg acacccacga gaagcaggac acactagttg ccctccgcca gc 1132 <210> 257 <211> 519 <212> DNA <213> Homo (Homo sapiens) <400> 257 gaattcgtga cacgaggtgc tcgagatgaa ccccagcgcc cccagctacc ccatggcctc 60 tctgtacgtg ggggacctgc accccgacgt gaccgaggcg atgctctacg agaagttcag 120 cccggccggg cccatcctct ccatccgggt ctgcagggac atgatcaccc gccgctcctt 180 gggctacgcg tacgtgaact tccagcagcc ggcggacgcg gaacgtgctt tggacaccat 240 gaattttgat gttataaagg gcaagccagt acgcatcatg tggtctcagc gtgatccatc 300 acttcgcaaa agtggagtag gcaacatatt cattaaaaat ttggacaaat ccatcgacaa 360 taaagcacta tatgatacgt tttctgcgtt tggtaacatc ctttcatgta aggtggtttg 420 tgatgaaaat ggctccaagg gctatggatt tgtacacttt gaaacacagg aagcagctga 480 aagagctatt gaaaaaatga atgggatgct tctaaatga 519 <210> 258 <211> 596 <212> DNA <213> Homo (Homo sapiens) <400> 258 gctttgccaa agacttagaa gctaagcaga aaatgagctt aacatcctgg tttttggtga 60 gcagtggagg cactcgccac aggctgccac gagaaatgat ttttgttgga agagatgact 120 gtgagctcat gttgcagtct cgtagtgtgg ataagcaaca cgctgtcatc aactatgatg 180 cgtctacgga tgagcattta gtgaaggatt tgggcagcct caatgggact tttgtgaatg 240 atgtaaggat tccggaacag acttatatca ccttgaaact tgaagataag ctgagatttg 300 gatatgatac aaatcttttc actgtagtac aaggagaaat gagggtccct gaagaagctc 360 ttaagcatga gaagtttacc attcagcttc agttgtccca aaaatcttca gaatcagaat 420 tatccaaatc tgcaagtgcc aaaagcatag attcaaaggt agcagacgct gctactgaag 480 tgcagcacaa aactactgaa gcactgaaat ccgaggaaaa agccatggat atttctgcta 540 tgccccgtgg tactccatta tatgggcagc cgtcatggtg gggggatgat gaggtg 596 <210> 259 <211> 595 <212> DNA <213> Homo (Homo sapiens) <400> 259 gaattcggca ccagagaaaa agcttcaagg tatattgagt cagagtcaag ataaatcact 60 tcggagaatt tcagaattaa gagaggagct gcaaatggac cagcaagcaa agaaacatct 120 tcaggacgag tttgatgcat gtttggagga gaaagatcag tatatcagtg ttctccagac 180 tcaggtttct cttctaaagc agcgattaca gaatggccca atgaatgttg atgctcccaa 240 acccctccct cccggggagc tccaggcaga agtgcacggt gacacggaga agatggaggg 300 cgtcggggaa ccagtgggag gtgggacttc cgctaaaacc ctggaaatgc tccagcaaag 360 agtgaaacgt caggagaatc tgcttcagcg ctgtaaggag acaattgggt cccacaagga 420 gcagtgcgca ctgctgctga gtgagaagga ggcactgcag gagcagttgg atgaaaggct 480 gcaggagctg gaaaagatga aggggatggt aataaccgag acgaagcggc aaatgcttga 540 gaccctggaa ctgaaagaag atgaaattgc tcagcttcgt agtcatatca aacag 595 <210> 260 <211> 994 <212> DNA <213> Homo (Homo sapiens) <400> 260 gaattcggca cgaggcgttg cctgccttct tgctgtctat cagcctttct tgcctcttcc 60 ttttcgcctt ccctgttctt ccctttctca aacaaacaag acatggcaaa ccgcagtcta 120 acccagccct ttgaaattat ccatagtttt acagacagct ccaggccatg agccacaatg 180 tccaaaatta ttcttgagca ctgatataaa ttacttagac cttctttgag ggcagaactc 240 agctgttgct ctcatgatgg gcagtgctgg aaagggttct ggtatgtctt caaaatgagt 300 ccacgagttt actgagtgct tacaggtaaa ggaatgaata taagatgtct ttctgatcag 360 aacaggtgtc ccttcacatg agctttacta gactctggga gggaaaagta gccaagtact 420 tctgaaccat tttttaatac ttgttttgtc atggtgaaat tatagcagtt atcccaaaat 480 gttttaatta tcaaaatact gtcttttaaa aaaaaaaaaa agtaacacct tttaaagcat 540 tagatttcac ttgggtttct tttccaaaaa atgctaggta gacaaggcat tgtaaacatg 600 agtttccttt aagaaccatc agaatataaa tttaacatga agaaaactgc tatatctagt 660 agaaataata tctaaagttt aacaactaaa gtaccctcac agaatagcaa atacccttct 720 gttctggaca tgggttcaaa tttgaatatg gaaataattt ccttggaagt ccctagaggc 780 aggtcagagg aagtatgcat taagagggaa aggagagaat ggaaataaaa gtcactataa 840 tgcagattta tgccttattt tttagcattt tttaaatgtt gggtctttca aggtgttttt 900 tgctttttat tagatctata taaataagtt aactagcaat ttagttttgt atttaagcta 960 cacttaatct ttttctttgg tgatatttat ttct 994 <210> 261 <211> 594 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (538) <223> n = A, T, C or G <400> 261 gaattcggca ccagtggaga tccagctgaa ccatgccaac cgccaggctg cggaggcaat 60 caggaacctt cggaacaccc agggaatgct gaaggacaca cagctgcacc tggacgatgc 120 tctcagaggc caggacgacc tgaaagagca gctggccatg gttgagcgca gagccaacct 180 gatgcaggct gagatcgagg agctcagggc atccctggaa cagacagaga ggagcaggag 240 agtggccgag caagagctac tggatgccag tgagcgcgtg cagctcctcc acacccagaa 300 caccagcctc atcaacacca agaagaagct ggagacagac atttcccaaa tccagggaga 360 gatggaagac atcgtccagg aagcccgcaa cgcagaagag aaggccaaga aagccatcac 420 tgatgccgcc atgatggcgg aggagctgaa gaaggagcag gacaccagcg cccacctgga 480 gcggatgaag aagaacatgg agcagaccgt gaaggacctg cagcaccgtc tggacgangc 540 tgagcagctt ggcgctgaag ggcgggcaag aagcagatcc agaaactgga ggct 594 <210> 262 <211> 594 <212> DNA <213> Homo (Homo sapiens) <400> 262 gaaaaggtgg ctggagccaa aggcatagtc agggttaatg ctcctttttc tttatcccaa 60 atcagatagt gtttaggctt tttcatcaaa tataaaaacc cagcccagtt catggctcat 120 tcggcagcaa ccctgagacg ctttacagct ctagacccta aaaggtcaaa aggccgtctt 180 atgctcaata tacattttat tacccaatct gccccggaca ttaaataaaa ctccaaaaat 240 taaatccggc cctcaaaccc cacaacagga cttaattgac ctcaccttca aggtgtagaa 300 taataaaaaa aaaaagttgc aattccttgc ctccgctgtg agacaaaccc cagccacatc 360 tccagcacac aagaacttcc aaacgcctga accacagcag ccaggcgttc ctccagaacc 420 tcctccccca ggagcttgct acatgtgccg gaaatctggc cactaggcca aggaatgcct 480 gcagccccgg attcctccta agccgtgtcc catctgtgcg ggaccccact gaaaatcgga 540 ctgttcaact cacctggcag ccactctcag agaccctgga actctggccc aagg 594 <210> 263 <211> 506 <212> DNA <213> Homo (Homo sapiens) <400> 263 gaattcggca cgagcggaaa cttaggggcc acgtgagcca cggccacggc cgcataggca 60 agcaccggaa gcaccccggc ggccgcggta atgctggtgg tctgcatcac caccggatca 120 acttcgacaa ataccaccca ggctactttg ggaaagttgg tatgaagcat taccacttaa 180 agaggaacca gagcttctgc ccaactgtca accttgacaa attgtggact ttggtcagtg 240 aacagacacg ggtgaatgct gctaaaaaca agactggggc tgctcccatc attgatgtgg 300 tgcgatcggg ctactataaa gttctgggaa agggaaagct cccaaagcag cctgtcatcg 360 tgaaggccaa attcttcagc agaagagctg aggagaagat taagagtgtt gggggggcct 420 gtgtcctggt ggcttgaagc cacatggagg gagtttcatt aaatgctaac tactttttaa 480 aaaaaaaaaa aaaaaaaaaa ctcgag 506 <210> 264 <211> 600 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_featute <222> (32) <223> n = A, T, C or G <400> 264 ggctcgtgaa cacacactga cagctatagg gnaggcggcg gcaccgtccc cgcttcccct 60 cggcggcggg gtgtcccgtc ggcggccctg aagtgaccca taaacatgtc ttgtgagagg 120 aaaggcctct cggagctgcg atcggagctc tacttcctca tcgcccggtt cctggaagat 180 ggaccctgtc agcaggcggc tcaggtgctg atccgcgagg tggccgagaa ggagctgctg 240 ccccggcgca ccgactggac cgggaaggag catcccagga cctaccagaa tctggtgaag 300 tattacagac acttagcacc tgatcacttg ctgcaaatat gtcatcgact aggacctctt 360 cttgaacaag aaattcctca aagtgttcct ggagtacaaa ctttattagg agctggaaga 420 cagtctttac tacgcacaaa taaaagctgc aagcatgttg tgtggaaagg atctgctctg 480 gctgcgttgc actgtggaag accacctgag tcaccagtta actatggtag cccacccagc 540 attgcggata ctctgttttc aaggaagctg aatgggaaat acagacttga gcgacttgtt 600 <210> 265 <211> 534 <212> DNA <213> Homo (Homo sapiens) <400> 265 gaattcggca cgagtgagga gcccatcatg gcgacgcccc ctaagcggcg ggcggtggag 60 gccacggggg agaaagtgct gcgctacgag accttcatca gtgacgtgct gcagcgggac 120 ttgcgaaagg tgctggacca tcgagacaag gtatatgagc agctggccaa ataccttcaa 180 ctgagaaatg tcattgagcg actccaggaa gctaagcact cggagttata tatgcaggtg 240 gatttgggct gtaacttctt cgttgacaca gtggtcccag atacttcacg catctatgtg 300 gccctgggat atggtttttt cctggagttg acactggcag aagctctcaa gttcattgat 360 cgtaagagct ctctcctcac agagctcagc aacagcctca ccaaggactc catgaatatc 420 aaagcccata tccacatgtt gctagagggg cttagagaac tacaaggcct gcagaatttc 480 ccagagaagc ctcaccattg acttcttccc cccatcctca gacattaaag agcc 534 <210> 266 <211> 552 <212> DNA <213> Homo (Homo sapiens) <400> 266 gaattcggca ccagggcacc tccgcctcgc cgccgctagg tcggccggct ccgcccggct 60 gccgcctagg atgaatatca tggacttcaa cgtgaagaag ctggcggccg acgcaggcac 120 cttcctcagt cgcgccgtgc agttcacaga agaaaagctt ggccaggctg agaagacaga 180 attggatgct cacttagaga acctccttag caaagctgaa tgtaccaaaa tatggacaga 240 aaaaataatg aaacaaactg aagtgttatt gcagccaaat ccaaatgcca ggatagaaga 300 atttgtttat gagaaactgg atagaaaagc tccaagtcgt ataaacaacc cagaactttt 360 gggacaatat atgattgatg cagggactga gtttggccca ggaacagctt atggtaatgc 420 ccttattaaa tgtggagaaa cccaaaaaag aattggaaca gcagacagag aactgattca 480 aacgtcagcc ttaaattttc ttactccttt aagaaacttt atagaaggag attacaaaac 540 aattgctaaa ga 552 <210> 267 <211> 551 <212> DNA <213> Homo (Homo sapiens) <400> 267 gaagcctacc agccaggtgc cggccccccc acccccggcc cagccccctc ctgcagcggt 60 ggaagcggct cggcagatcg agcgtgaggc ccagcagcag cagcacctgt accgggtgaa 120 catcaacaac agcatgcccc caggacgcac gggcatgggg accccgggga gccagatggc 180 ccccgtgagc ctgaatgtgc cccgacccaa ccaggtgagc gggcccgtca tgcccagcat 240 gcctcccggg cagtggcagc aggcgcccct tccccagcag cagcccatgc caggcttgcc 300 caggcctgtg atatccatgc aggcccaggc ggccgtggct gggccccgga tgcccagcgt 360 gcagccaccc aggagcatct cacccagcgc tctgcaagac ctgctgcgga ccctgaagtc 420 gcccagctcc cctcagcagc aacagcaggt gctgaacatt ctcaaatcaa acccgcagct 480 aatggcagct ttcatcaaac agcgcacagc caagtacgtg gccaatcagc ccggcatgca 540 gccccagcct g 551 <210> 268 <211> 573 <212> DNA <213> Homo (Homo sapiens) <400> 268 gaattcggca ccagggttcc ttgtgggcta gaagaatcct gcaaaaatgt ctctctatcc 60 atctctcgaa gacttgaagg tagacaaagt aattcaggct caaactgctt tttctgcaaa 120 ccctgccaat ccagcaattt tgtcagaagc ttctgctcct atccctcacg atggaaatct 180 ctatcccaga ctgtatccag agctctctca atacatgggg ctgagtttaa atgaagaaga 240 aatacgtgca aatgtggccg tggtttctgg tgcaccactt caggggcagt tggtagcaag 300 accttccagt ataaactata tggtggctcc tgtaactggt aatgatgttg gaattcgtag 360 agcagaaatt aagcaaggga ttcgtgaagt cattttgtgt aaggatcaag atggaaaaat 420 tggactcagg cttaaatcaa tagataatgg tatatttgtt cagctagtcc aggctaattc 480 tccagcctca ttggttggtc tgagatttgg ggaccaagta cttcagatca atggtgaaaa 540 ctgtgcagga tggagctctg ataaagcgca caa 573 <210> 269 <211> 500 <212> DNA <213> Homo (Homo sapiens) <400> 269 gaatcggcac caggaaacct ttattagcag agatagctgg cttggatcag attacgggga 60 atgtggggga gccatgaaga aactaactaa aggggagcct ttggggacca gggggagaca 120 agtcactatt ttgagggaga aagctctgga ttgattctga caggacactt gagtgtgaac 180 tgtccaagct aagcctctgg gtgtgtagag agagccctta cagatagata gcacctttgc 240 tttcagagtg gaaggactag ccactaagga ccagaccaag atgcatgtag gtcactgaca 300 agcacctgat gaagaggagg ggtctcctcc aagtttgtgt ttggaactcc tcctgtgttc 360 aatttcctaa aagccataat ccagcaagct gaactcatga gaaggtctgc ttcatgttga 420 gcatggaaga cagaacacag acggaaactg cagtgatggt gtgaagacac cacggatagg 480 ttaggggcag tgaggaggaa 500 <210> 270 <211> 224 <212> DNA <213> Homo (Homo sapiens) <400> 270 gaattcggca cgagaagact acaatctcca gggaaacctg gggcgtctcg cgcaaacgtc 60 cataactgaa agtagctaag gcaccccagc cggaggaagt gagctctcct ggggcgtggt 120 tgttcgtgat ccttgcatct gttacttagg gtcaaggctt gggtcttgcc ccgcagaccc 180 ttgggacgac ccggccccag cgcagctatg aacctggagc gagt 224 <210> 271 <211> 447 <212> DNA <213> Homo (Homo sapiens) <400> 271 gaattcggca cgaggctggg ccgggcccga gcggatcgcg ggctcgggct gcggggctcc 60 ggctgcgggc gctgggccgc gaggcgcgga gcttgggagc ggagcccagg ccgtgccgcg 120 cggcgccatg aagggcaagg aggagaagga gggcggcgca cggctgggcg ctggcggcgg 180 aagccccgag aagagcccga gcgcgcagga gctcaaggag cagggcaatc gtctgttcgt 240 gggccgaaag tacccggagg cggcggcctg ctacggccgc gcgatcaccc ggaacccgct 300 ggtggccgtg tattacacca accgggcctt gtgctacctg aagatgcagc agcacgagca 360 ggccctggcc gactgccggc gcgccctgga gctggacggg cagtctgtga aggcgcactt 420 cttcctgggg cagtgccagc tggagat 447 <210> 272 <211> 606 <212> DNA <213> Homo (Homo sapiens) <400> 272 gcaactactt atattccttt gatggataat gctgactcaa gtcctgtggt agataagaga 60 gaggttattg atttgcttaa acctgaccaa gtagaaggga tccagaaatc tgggactaaa 120 aaactgaaga ccgaaactga caaagaaaat gctgaagtga agtttaaaga ttttcttctg 180 tccttgaaga ctatgatgtt ttctgaagat gaggctcttt gtgttgtaga cttgctaaag 240 gagaagtctg gtgtaataca agatgcttta aagaagtcaa gtaagggaga attgactacg 300 cttatacatc agcttcaaga aaaggacaag ttactcgctg ctgtgaagga agatgctgct 360 gctacaaagg atcggtgtaa gcagttaacc caggaaatga tgacagagaa agaaagaagc 420 aatgtggtta taacaaggat gaaagatcga attggaacat tagaaaagga acataatgta 480 tttcaaaaca aaatacatgt cagttatcaa gagactcaac agatgcagat gaagtttcag 540 caagttcgtg agcagatgga ggcagagata gctcacttga agcaggaaaa tgggtatact 600 ggagaa 606 <210> 273 <211> 598 <212> DNA <213> Homo (Homo sapiens) <400> 273 gaattcggca ccaggcccgg tcccgcggtc gcagctccag ccgcctcctc cgcgcagccg 60 ccgcctcagc tgctcgctct gtgggtcggt cctctccggc acttgggctc cagtcgcgcc 120 ctccaagccc ttcaggccgc cccagtgtcc tcctccttct ccggccagac ccagccccgc 180 gaagatggtg gaccgcgagc aactggtgca gaaagcccgg ctggccgagc aggcggagcg 240 ctacgacgac atggccgcgg ccatgaagaa cgtgacagag ctgaatgagc cactgtcgaa 300 tgaggaacga aaccttctgt ctgtggccta caagaacgtt gtgggggcac gccgctcttc 360 ctggagggtc atcagtagca ttgagcagaa gacatctgca gacggcaatg agaagaagat 420 <210> 274 <212> DNA <213> Homo (Homo sapiens) <400> 274 <210> 275 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (379) <400> 275 <210> 276 <211> 484 <212> DNA <213> Homo (Homo sapiens) <400> 276 <210> 277 <211> 513 <212> DNA <213> Homo (Homo sapiens) <400> 277 <210> 278 <212> DNA <213> Homo (Homo sapiens) <400> 278 <210> 279 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <221> misc_feature <400> 279 <210> 280 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <400> 280 <210> 281 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <400> 281 <210> 282 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <400> 282 <210> 283 <211> 484 <212> DNA <213> Homo (Homo sapiens) <400> 283 <210> 284 <212> DNA <213> Homo (Homo sapiens) <400> 284 <210> 285 <212> DNA <213> Homo (Homo sapiens) <400> 285 <210> 286 <212> DNA <213> Homo (Homo sapiens) <400> 286 <210> 287 <212> DNA <213> Homo (Homo sapiens) <400> 287 <210> 288 <212> DNA <213> Homo (Homo sapiens) <400> 288 <210> 289 <212> DNA <213> Homo (Homo sapiens) <400> 289

<210>290

<211>300

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(300)

＜223〉n=A, T, C or G

<400>290gattcaagat?gtaccccatt?gactttgaga?aggatgatga?cagcaacttt?catatggatt?????60tcatcgtggc?tgcatccaac?ctccgggcag?aaaactatga?cattccttct?gcagaccggc????120acaagagcaa?gctgattgca?gggaagatca?tcccagccat?tgccacgacc?acagcagccg????180tggttggcct?tgtgtgtctg?gagctgtaca?aggttgtgca?ggggcaccga?cancttgact????240cctacangaa?tgggtgcctc?aacttgagcc?ctgcctttct?ttggtttctc?tgaacccctt????300

<210>291

<211>352

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(352)

＜223〉n=A, T, C or G

<400>291aaccaagctg?ccaccggggg?tggatcggat?gcggcttgag?aggcatctgt?ctgccgagga?????60cttctcaagg?gtatttgcca?tgtcccctga?agagtttggc?aagctggctc?tgtggaagcg????120gaatgagctc?aagaagaagg?cctctctctt?ctgatggccc?ccacctgctc?cgggacggcc????180cccttacccc?tgctgcttca?gggtttttcc?ccggcgggtt?gggaggggca?ggaggtgggg????240tggaaatngg?gtgggcncct?ttcctcaggt?agagnggggg?gccaaaacct?ctgcngtccc????300cggagngagc?tatggacttt?cttccccctc?acaaggntgg?gggcctcctg?ct????????????352

<210>292

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>292cgcggtggct?gcgcactcng?cctgagaaac?tcggcaagcg?cgcagtgtcg?actccccggt?????60ctatgccagg?cgcatctcag?ctaatccaaa?agtaaatgag?aaacttagaa?aaagattgcc????120aattccaaat?caacatattt?agagaaaatt?ggaaaaggag?aagcttacta?cagctttatt????180tgaggacttt?ttaaagaacg?ctgggttcta?tctgtgagct?gcaaatcttg?gagcaaaaac????240cagagacatt?gccagagcaa?acaagaacag?aaatacaaat?ggagaactgg?tcaaaagaca????300taacccacag?ttatcttgaa?caagaaacta?cggggataaa?taaaagtacg?canccagatg????360agcaactgac?tatgaattct?gagaaaagta?tgcatcggaa?atccactgaa?ttagntaatg????420aaataacatg?ngagaacaca?gaatggccag?gggcagagat?caacgaattt?tcanatcatc????480agttcttatc?cagatgatga?gtctgtttac?t???????????????????????????????????511

<210>293

<211>526

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(526)

＜223〉n=A, T, C or G

<400>293gataaaaaga?actttaatgg?aaggcactgt?tgtccaaaat?cacataaagg?gtaagagccc?????60acacggtacc?accctgctct?cctacttctc?aaacccacat?ccaccaccca?gacaggaggg????120tgcanacccc?acaggaaatt?acctcccgga?gcactgactg?atatttttcc?ttaaaacaaa????180aaaatggctg?tctcagacta?ataacagaac?atcttaagag?ctataccagc?tattacagcc????240tggtaatana?agcagctttc?taanaattcc?caagtttata?anaggcccaa?naaatgcatt????300tattctgttg?tctattaagc?ctccatgaca?aggagaaagt?tatgagtaaa?tccttggttc????360atcaggagtt?aagagctgtg?ngcctcatga?ggagttaana?gctgtgtgca?taagcaggtt????420caagaaacaa?actcctgttt?gtttgcctct?ttgatggttc?aaaaacattc?agctgctttc????480acctctanga?caaaatgctt?aaagaattta?ctctcatcac?cttggg???????????????????526

<210>294

<211>601

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(601)

＜223〉n=A, T, C or G

<400>294actttaaaag?ccaaatatat?ttttaaaaga?tcatgcttat?aataagtaaa?ttacncatta?????60aggaaacatc?aaaataaagt?agatgaataa?aaaggcacac?tcgaaaaatt?tgagcgcaga????120aaggacagtt?ctttttgttt?tgtttctaat?gtcggaagaa?aaagaaagag?atatattaaa????180atcattgttt?tcaagtgaag?gtttctgtca?gttgaagtag?ttagcaatgg?cttcttttct????240cccgtgtcca?aagcaggctc?ttcctgcgct?gacttctgag?gaggngttca?gtcctctgcc????300atgtataggc?gatacatcaa?ggcgacggcc?actgcagaga?tggcagggat?cacccagttg????360gtccaccaac?tggaactaga?atcaatagta?gtgataagag?tttccggagg?cttgtttaac????420tttggtctgt?catctggatg?gagctcccca?atgatgaatg?ttttggacat?ttccctggca????480tctgtagant?gcccgacatc?ctcaaagttc?tcagtagcng?tcacctccac?ttgttccctt????540aaaacttctt?ccccaccagg?atgctcttcc?agaaatttgg?gncaaatcgn?acaccttgtg????600g????????????????????????????????????????????????????????????????????601

<210>295

<211>262

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>295cccttagccc?caagggccct?gggggcagcc?accctcccgc?ctgtcggccc?gtagatttat?????60caagggtgtt?atgggcccag?ctttgggggg?ccagtcccga?tgcactttga?ggggtgttgg????120agaggggact?cccccactcg?cacttaactc?aacggctctc?gggccctggg?gctgttttta????180ccatgtttgt?ttttgaagct?caggtgtctc?acgtctgggc?tgcaccaggc?gaagagagaa????240attaaagatt?tgaggttttt?cc?????????????????????????????????????????????262

<210>296

<211>598

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(598)

＜223〉n=A, T, C or G

<400>296gttagaacaa?ctcagcaaaa?taaaattcct?gtttattgtt?ggacaacatt?gtttcacaca?????60tacatcaaac?aggccaaaaa?aaataaacag?caacttcata?gacaaaaaag?gaaaaaaaaa????120gaaacctttt?atctttggcc?tttttaacca?tctcatacaa?accaactact?tatagtacag????180ctaagtacat?acacaaaaaa?gttactggaa?tgctcggaat?aagattgttt?ttctgttgtc????240atttttgctt?tttttacaag?gntttttttc?tcctttgaga?ttataatgaa?catggncaca????300ccacaagtaa?agtcagaagt?aggacagana?acgctccgaa?ggctggtttg?gtcatccgan????360atcattaaaa?atggctgacc?ctaacaatat?gtacaaaaat?ataaaatgta?aataaaaaat????420acaaacaaat?ttccttttta?aagtactttt?aagaaaaaaa?gcagggcctt?ggaagttttg????480gttctttttt?cctcccctgt?tgcaaattct?catggtttgg?gttgggtggn?gganancccg????540tgtcatctgc?gggtggcact?gccccggngg?gcgggcgggc?ctctctctcg?aangngac??????598

<210>297

<211>509

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>297agaacacagg?tgtcgtgaaa?actaccccta?aaagccaaaa?tgggaaagga?aaagactcat?????60atcaacattg?tcgtcattgg?acacgtagat?tcgggcaagt?ccaccactac?tggccatctg????120atctataaat?gcggtggcat?cgacaaaaga?accattgaaa?aatttgagaa?ggaggctgct????180gagatgggaa?agggctcctt?caagtatgcc?tgggtcttgg?ataaactgaa?agctgagcgt????240gaacgtggta?tcaccattga?tatctccttg?tggaaatttg?agaccagcaa?gtactatgtg????300actatcattg?atgccccagg?acacagagac?tttatcaaaa?acatgattac?agggacatct????360caggctgact?gtgctgtcct?gattgttgct?gctggtgttg?gtgaatttga?agctggtatc????420tccaagaatg?ggcaggaccc?gagagcatgc?ccttctggct?tacacactgg?gtgtgaaaca????480actaattgtc?ggtgttaaca?aaatggatt??????????????????????????????????????509

<210>298

<211>267

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(267)

＜223〉n=A, T, C or G

<400>298gggacggggg?aaaggagacg?cttcttcctc?ttgctgctct?tctcgttccc?gagatcagcg?????60gcggcggtga?ccgcgagtgg?gtcggcaccg?tctccggctc?cgggngcnaa?caatgctgac????120tgatagcgga?ggcggnggca?cctccttnna?ggaggacctg?gactctgtgg?ctccgcgatc????180cgccccagct?ggggcctcgg?agccgcctcc?gccgggaggg?gtcggtctgg?ggatccncac????240cgngaggctn?tttggggagg?gcgggcc????????????????????????????????????????267

<210>299

<211>121

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>299ggcacgaggg?ccctcggagc?tcgtttccag?atcgaggtaa?gagggacttt?cttaaaggcc?????60tagtctatgg?gatggggcgg?cggagggaat?tttttgagaa?ataaaatgaa?gctgcagtgt????120a????????????????????????????????????????????????????????????????????121

<210>300

<211>533

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>300aaggtgcaca?gtatttgatg?caggctgctg?gtcttggtcg?tatgaagcca?aacacacttg?????60tccttggatt?taagaaagat?tggttgcaag?cagatatgag?ggatgtggat?atgtatataa????120acttatttca?tgatgctttt?gacatacaat?atggagtagt?ggttattcgc?ctaaaagaag????180gtctggatat?atctcatctt?caaggacaag?aagaattatt?gtcatcacaa?gagaaatctc????240ctggcaccaa?ggatgtggta?gtaagtgtgg?aatatagtaa?aaagtccgat?ttagatactt????300ccaaaccact?cagtgaaaaa?ccaattacac?acaaagttga?ggaagaggat?ggcaagactg????360caactcaacc?actgttgaaa?aaagaatcca?aaggccctat?tgtgccttta?aatgtagctg????420accaaaagct?tcttgaagct?agtacacagt?ttcagaaaaa?acaaggaaag?aatactattg????480atgtctggtg?gctttttgat?gatggaggtt?tgaccttatt?gataccttac?ctt???????????533

<210>301

<211>560

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(560)

＜223〉n=A, T, C or G

<400>301ataaatgatc?ccttttattg?taagtaatgc?gcaacactgg?cctggctttg?cactgcaagc?????60cctcggtcaa?gatatagtca?aataactatg?gctgcaggtt?ccacagttcc?acaataacca????120tggctgcacg?atccacaatt?cagacacaga?catagagctg?gggtgggtgg?aaggggcagg????180agggtggcag?agtgcggact?gtccccagcc?ctggcctctc?catgcanagt?tggcccaggc????240agacacaccc?catggaatga?tgagaaagtg?acggcacggc?cccttcccac?agcaagcctg????300gggctgccag?gaactgccct?tcanaacctt?tgggcccagg?tcnccctgaa?nccccacaac????360tttttatctg?gaataagtat?taaaaaacaa?taaattaagc?aaacaacntg?gnccttgaag????420gatgttgacc?nacatggtcc?acagtttttg?gcncaaaaaa?ataagggctg?gtttgctttt????480tttggaaggc?agggtttgtg?gnttggcttt?caaatnattt?tcaaaccatt?ccccagggag????540gganaacccc?cgggggggaa????????????????????????????????????????????????560

<210>302

<211>599

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(599)

＜223〉n=A, T, C or G

<400>302gcaaagttac?aaatttattg?gtctggaaat?aaatacaaat?atctcattaa?naaactcctc?????60tggaaagact?tgtgcacaat?agtttcccat?ccgtactcag?cctctcttgc?cccgatcccc????120gacttttcta?ctcaaggcca?gggaaggcct?ccaaggngat?gggcggcagg?taacgagtca????180ttgcctctca?cgccacctgg?aaggctggac?tacttcctcc?tcccaactgc?ggggtcccan????240aaatcctcgg?gtcccagngg?ctgacttaca?atattcaatt?cactctgacc?aaacttccta????300tganaaaatc?cacggngagc?caaaatgaaa?agtacaaggc?agtagtacag?gaacctggca????360gccgcactgg?ccgcccanaa?acgtcagtgg?ngctgcccca?ttcggcgaaa?ggttagggag????420caggaaaaga?ggaagcagga?gagggaagga?aagtcccatg?gaatatgtat?tccanaatcc????480ttacattttc?tcagccaccg?ctccccacgt?gagttcccac?ccccaccccg?acaagaagca????540aagagttctg?aggatccaag?aacgtgaccg?ggtcanacan?gttcagctac?tgagttcac?????599

<210>303

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>303cggagttgta?acgctccact?gactgataga?gcgaccggcc?gaccatggcg?cccggagtgg?????60cccgcgggcc?gacgccgtac?tggaggttgc?gcctcggtgg?cgccgcgctg?ctcctgctgc????120tcatcccggt?ggccgccgcg?caggagcctc?ccggagctgc?ttgttctcag?aacacaaaca????180aaacctgtga?agagtgcctg?aagaacgtct?cctgtctttg?gtgcaacact?aacaaggctt????240gtctggacta?cccagttaca?agcgtcttgc?caccggcttc?cctttgtaaa?ttgagctctg????300cacgctgggg?agtttgttgg?gtgaactttg?aggcgctgat?catcaccatg?tcggtagtcg????360ggggaaccct?cctcctgggc?attgccatct?gctgctgctg?ctgctgcagg?aggaagagga????420gccggaagcc?ggacaggagt?gaggagaagg?ccatgcgtga?gcgggaggag?aggcggatac????480ggcaggagga?acggagagca?gagatgaaga?caagacatga?tgaaatcaga?aaaaaatatg????540gcctgtttaa?agaagaaaac?ccgtatgcta?gatttgaaaa?caactaaagc?g?????????????591

<210>304

<211>441

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(441)

＜223〉n=A, T, C or G

<400>304gctggacgga?gacctgctgg?aggaggagga?gctggaggaa?gcagaggagg?aggaccggtc?????60gtcgctgctg?ctgctgtcgc?cgcccgcggc?caccgcctct?cagacccagc?agatcccagg????120cgggtccctg?gggtctgtgc?tgctgccagc?cgccaggttc?gatgcccggg?aggcggcggc????180ggcggcgggg?gtgctgtacg?gaggggacga?tgcccagggc?atgatggcgg?cgatgctgtc????240ccacgcctac?ggccccggcg?gttgtggggc?ggcggcggcc?gccctgaacg?gggagcaggc????300ggccctgctc?cggagaaaga?gcgtcaacac?caccgagtgc?gtcccggtgc?ccagctccga????360gcacgtcgcc?gagatcgtcg?gccgccaggg?ttgtaaaatt?aaagcactga?nagccaagac????420aaacacgtat?atcaagactc?c??????????????????????????????????????????????441

<210>305

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>305tcgccatgcc?cccttcttag?cactgcaccg?ccaggtccat?gctgctgcca?ccccagacct?????60gggctttgcc?tgccacctct?gtgggcagag?cttccgaggc?tgggtggccc?tggttctgca????120tctgcgggcc?cattcagctg?caaagcggcc?catcgcttgt?cccaaatgcg?agagacgctt????180ctggcgacga?aagcagcttc?gagctcatct?gcggcggtgc?caccctcccg?ccccggaggc????240ccggcccttc?atatgcggca?actgtggccg?gagctttgcc?cagtgggacc?agctagttgc????300ccacaagcgg?gtgcacgtag?ctgaggccct?ggaggaggcc?gcagccaagg?ctctggggcc????360ccggcccagg?ggccgccccg?cggtgaccgc?cccccggccc?ggtggagatg?ccgtcgaccg????420ccccttccag?tgtgcctgtt?gtggcaagcg?cttccggcac?aagcccaact?tgatcgctca????480cccgcgcgtg?c?????????????????????????????????????????????????????????491

<210>306

<211>547

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(547)

＜223〉n=A, T, C or G

<400>306tctctttctt?ttaagacagg?aatgtaagcc?acaacattta?caaatacaat?gttttaactc?????60tctacatgta?ggaagccaac?ctgctccttt?ttgatcttct?tctttggcac?aacctcagtg????120gatttctctg?attcagaacg?agttctaatt?gatcttctct?gttgcttctt?ttctactgag????180cctgtagaac?cagatgttgc?ttcaggagat?gatacactct?gcgttggctt?ttcatttctc????240tggtttggtg?tagaaattat?aagcctgtct?tgccccctga?cacttatttc?tgttttgtta????300ccaattccct?ttgttgaata?aacaaattga?tcgataaatt?tcccatcccc?tgtagcattc????360tgaagagcaa?acacttgttc?aattttcaca?actggagaca?tgttacactt?ctgcaaatcc????420aggctccctt?tgtgcatccg?taatggaagc?tggtaaggat?ttccttgctg?ccgcagtttt????480ccaggctatt?ttaacaggcg?gnggctcttc?ctctttccgc?acttgtgtgc?cgcctctggc????540tatgtct??????????????????????????????????????????????????????????????547

<210>307

<211>571

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(571)

＜223〉n=A, T, C or G

<400>307cgctgcatgt?gataatgtca?tcatttattt?ttaaatggtt?ctaaattgca?natttaagtt?????60gatttcaaat?caaccctatt?tttaaattac?ttttaatagg?aanaaatgaa?gcaaggacat????120acataatcta?ctatatttga?aggactcaaa?caaatacatg?tttggctgtg?aattctgtac????180tctcaccaaa?acagagataa?aaatccacct?aaaatacact?ttccttcatt?tagtgcttgt????240ggganaaggt?caagtattgc?actttaaaat?tactttcatc?taacatttgc?cccaactttc????300cccctgaatt?cactatatgt?tttcagcaaa?catgatttta?taaattttaa?gtataaaagc????360aactaggttt?tctaattcaa?ctttggaagg?tttactttac?tctacanagc?tatttttgta????420aaacggcata?tttacttaca?aaattganag?ataggggcat?ccagctgagg?tacatttcct????480cccttggcgt?tgagtttctg?gacttgggtc?gggggcacag?gcttgtgtga?ctgccccgtg????540gcccgataca?tggcctggac?cccaggatgc?g???????????????????????????????????571

<210>308

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(591)

＜223〉n=A, T, C or G

<400>308ctccttatgt?gtctgcctac?ttcattcttc?ggcatttcct?gcttatccaa?gttcaccatt?????60tcaggtcacc?actggatatc?agttgcctgt?atataattat?caggcatttc?ctgcttatcc????120aagttcacca?tttcaggtca?ccactggata?tcagttgcct?gtatataatt?atcaggcatt????180tcctgcttat?ccaagttcac?catttcaggt?caccactgga?tatcagttgc?ctgtatataa????240ttatcaggca?tttcctgctt?atccaagttc?accatttcag?gtcaccactg?gatatcagtt????300gcctgtatat?aattatcagg?catttcctgc?ttatccaagt?tcaccatttc?aggtcaccac????360tggatatcag?ttgcctgtat?ataattatca?ggcatttcct?gcttatccaa?gttcaccatt????420tcaggtcacc?actggatatc?agttgcctgt?atataattat?caggcatttc?ctgcttatcc????480aaattcagca?gttcaggtca?ccactggata?tcagttccat?gtatacaatt?accagatgcc????540accgcagtgc?cctgttgggg?gagcaaagga?gaaatntgtg?gaccgaagca?t?????????????591

<210>309

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>309agggggtgca?cgtactccca?actgtggtcg?cgctctcacc?ccttctgctg?ctctcgtggc?????60cccctcgcga?tggcgggcat?cctgtttgag?gatattttcg?atgtgaagga?tattgacccg????120gagggcaaga?agtttgaccg?aggtaagtaa?gtgtctcgac?tgcattgtga?gagtgaatct????180ttcaagatgg?atctaatctt?agatgtaaac?attcaaattt?accctgtaga?cttgggtgac????240aagtttcggt?tggtcatagc?tagtaccttg?tatgaagatg?gtaccctgga?tgatggtgaa????300tacaacccca?ctgatgatag?gccttccagg?gctgaccagt?ttgagtatgt?aatgtatgga????360aaagtgtaca?ggattgaggg?agatgaaact?tctactgaag?cagcaacacg?cctgctgaga????420ttgagagctg?ctgagtggca?gtgctccaga?atcacgggat?ggggccttct?gtttcagctc????480tgcgtacgtg?tcctatgggg?gcctgctcat?gaggctgcag?ggggatgcca?acaacctgca????540tggattcgag?gtggactcca?gagtttatct?cctgatgaag?aagctagcct?t?????????????591

<210>310

<211>488

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>310tggtctcaag?cctgaagagg?ctccgcccac?aagctggccc?atgaagttag?caatgcctgt?????60ggcttcagtc?aattgtcttg?agactgtgaa?gaggctgaaa?gacaccttcc?cgggtggaag????120aaggagttca?ctgaaaactt?atcttaaact?gacccttccc?tttgagtgag?tcttcattcc????180tctcccatgt?gggaacccag?cctccgatgc?cccggggact?aggggaaaca?gttggaggtc????240cgtgccgtcc?ccagcctgcc?acgggtgcga?ggacagccaa?gtcctgagtg?actcaagatg????300cttcacttac?atggaagaaa?cttctaaaac?tctaccgagt?ggtttttgta?tatactaaag????360ttctatttag?agcttttctg?ttttgggcaa?gttcgctgct?ccttctattt?gggcactttg????420gtttttgtac?tgtcttttgt?gacggcattg?attgaacatt?ttttactagt?agtcttatga????480cttttgta?????????????????????????????????????????????????????????????488

<210>311

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>311cccgtttntg?nagcaaaana?gggggaagat?ttataggtag?aggcgacaaa?cctaccgagc?????60ctggtgatag?ctggttgtcc?aagatagaat?cttagttcaa?ctttaaattt?gcccacagaa????120ccctctaaat?ccccttgtaa?atttaactgt?tagtccaaag?aggaacagct?ctttggacac????180taggaaaaaa?ccttgtagag?agagtaaaaa?atttaacacc?catagtaggc?ctaaaagcag????240ccaccaatta?agaaagcgtt?caagctcaac?acccactacc?taaaaaatcc?caaacatata????300actgaactcc?tcacacccaa?ttggaccaat?ctatcaccct?atagaagaac?taatgttagt????360ataagtaaca?tgaaaacatt?ctcctccgca?taagcctgcg?tcagattaaa?acactgaact????420gacaattaac?agcccaatat?ctacaatcaa?ccaacaagtc?attattaccc?tcactgtcaa????480cccaacacag?gcatgctcat?aaggaaaggt?t???????????????????????????????????511

<210>312

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>312gaacttgcgt?tgaaggaagc?agaaactgat?gaaataaaaa?ttttgctgga?agaaagcaga?????60gcccagcaga?aggagacctt?gaaatctctt?cttgaacaag?agacagaaaa?tttgagaaca????120gaaattagta?aactcaacca?aaagattcag?gataataatg?aaaattatca?ggtgggctta????180gcagagctaa?gaactttaat?gacaattgaa?aaagatcagt?gtatttccga?gttaattagt????240agacatgaag?aagaatctaa?tatacttaaa?gctgaattaa?acaaagtaac?atctttgcat????300aaccaagcat?ttgaaataga?aaaaaaccta?aaagaacaaa?taattgaact?gcagagtaaa????360ttggattcag?aattgagtgc?tcttgaaaga?caaaaagatg?aaaaaattac?ccaacaagaa????420gagaaatacg?aagctattat?ccagaacctt?gagaaagaca?gacaaaaatt?ggtcagcagc????480caggagcaag?acagagaaca?gttaattcag?aagcttaatt?gtgaaaaaga?tgaagctatt????540cagactgccc?taaaagaatt?taaattggag?agagaagttg?ttgagaaaga?g?????????????591

<210>313

<211>373

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(373)

＜223〉n=A, T, C or G

<400>313ttgattttta?ttctgnattt?tattactgaa?atangttgtc?ctantnatcc?caccccacaa?????60taaaaatntn?acccangccc?cccntttctt?tncctnatnc?cctnttccac?cacaccatcc????120cggaacaagt?gctccaggat?tccctgccca?ctggccattt?tggagtgtgn?ccattgggta????180gcaatgtgga?aaccaccaag?gcctttgtgg?anaaaatgga?gggggttgag?ggagncccan????240gaggggctna?tttgagggcc?tttgccactt?gctcataggc?gagctcnatc?tcctcntnat????300ctgnacangt?ggaagcaaat?tcttcccggg?cgtnggnant?gctnaagnac?cgatgcactc????360cccggaaggn?ctn???????????????????????????????????????????????????????373

<210>314

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(591)

＜223〉n=A, T, C or G

<400>314cccgtgccgc?cgccgcctcc?tgggaagaga?ggaagcggga?gaggagccca?cgtcgcctgt?????60cacccaatat?ctccagccgc?gcagtcccga?agagtgtaag?atgttcgcct?gcgccaagct????120cgcctgcacc?ccctctctga?tccgagctgg?atccagagtt?gcatacagac?caatttctgc????180atcagtgtta?tctcgaccag?aggctagtag?gactggagag?ggctctacgg?tatttaatgg????240ggcccagaat?ggtgtgtctc?agctaatcca?aagggagttt?cagaccagtg?caatcagcag????300agacattgat?actgctgcca?aatttattgg?tgcaggtgct?gcaacagtag?gagtggctgg????360ttctggtgct?ggtattggaa?cagtctttgg?cagccttatc?attggttatg?ccagaaaccc????420ttcgctgaag?cagcagctgt?tctcatatgc?tatcctggga?tttgccttgt?ctgaagctat????480gggtctcttt?tgtttgatgg?ttgctttctt?gattttgttt?gccatgtaac?aaattactgc????540ttgacatgtt?ggcattcata?ttaattacng?atgtaattct?gtgtatctta?c?????????????591

<210>315

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(591)

＜223〉n=A, T, C or G

<400>315aagcccttca?ccaacaaaga?tgcctatact?tgtgcaaatt?gcagtgcttt?tgtccacaaa?????60ggctgccgag?aaagtctagc?ctcctgtgca?aaggtcaaaa?tgaagcagcc?caaagggagc????120cttcaggcac?atgacacatc?atcactgccc?acggtcatta?tgagaaacaa?gccctcacag????180cccaaggagc?gtcctcggtc?cgcagtcctc?ctggtggatg?aaaccgctac?caccccaata????240tttgccaata?gacgatccca?gcagagtgtc?tcgctctcca?aaagtgtctc?catacagaac????300attactggag?ttggcaatga?tgagaacatg?tcaaacacct?ggaaattcct?gtctcattca????360acagactcac?taaataaaat?cagcaaggtc?aatgagtcaa?cagaatcact?tactgatgag????420ggtacagaca?tgaatgaagg?acaactactg?ggagactttg?agattgagtc?caaacagctg????480gaagcagagt?cttggagtcg?gataatagac?agcaagtttc?taaaacagcc?aaaagaaaga????540tgtgggtcaa?acngcgagaa?gtaatatatg?agttggatgc?agacagagtt?t?????????????591

<210>316

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>316gtttttataa?gaataaaatt?ccattcaagc?cagatggtgt?ttacattgaa?gaagttctaa?????60gtaaatggaa?aggagattat?gaaaaactgg?agcacaacca?cacttacatt?caatggcttt????120tccccctgag?agaacaaggc?ttgaacttct?atgccaaaga?actaactaca?tatgaaattg????180aggaattcaa?aaaaacaaaa?gaagcaatta?gaagattcct?cctggcttat?aaaatgatgc????240tagaattttt?tggaataaaa?ctgactgata?aaactggaaa?tgttgctcgg?gctgttaact????300ggcaggaaag?atttcagcat?ctgaatgagt?cccagcacaa?ctatttaaga?atcactcgta????360ttcttaaaag?ccttggtgag?cttggatatg?aaagttttaa?atctcctctt?gtaaaattta????420ttcttcatga?agctcttgtg?gagaatacta?ttcccaatat?taagcagagt?gctctagagt????480attttgttta?tacaattaga?gacagaagag?aaaggagaaa?gctcctgcgg?ttcgcccaga????540aacactacac?gccttcagag?aactttatct?ggggacccgc?ctcgaaaaga?a?????????????591

<210>317

<211>323

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>317ccaagctacg?gaagcaagtg?gaagagattt?ttaatttgaa?atttgctcaa?gctcttggac?????60tcaccgaggc?agtaaaagta?ccatatcctg?tgtttgaatc?aaacccggag?ttcttctatg????120tggaaggctt?gccagagggg?attcccttcc?gaagccctac?ctggtttgga?attccacgac????180ttgaaaggat?cgtccacggg?agtaataaaa?tcaagttcgt?tgttaaaaaa?cctgaactag????240ttatttccta?cttgcctcct?gggatggcta?gtaaaataaa?cactaaagct?ttgcagtccc????300ccaaaagacc?acgaagtcct?ggg????????????????????????????????????????????323

<210>318

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(591)

＜223〉n=A, T, C or G

<400>318gatggcgtac?ttggcttgga?gactggcgcg?gcgttcgtgt?ccgagttctc?tgcaggtcac?????60tagtttcccg?gtagttcagc?tgcacatgaa?tagaacagca?atgagagcca?gtcagaagga????120ctttgaaaat?tcaatgaatc?aagtgaaact?cttgaaaaag?gatccaggaa?acgaagtgaa????180gctaaaactc?tacgcgctat?ataagcaggc?cactgaagga?ccttgtaaca?tgcccaaacc????240aggtgtattt?gacttgatca?acaaggccaa?atgggacgca?tggaatgccc?ttggcagcct????300gcccaaggaa?gctgccaggc?agaactatgt?ggatttggtg?tccagtttga?gtccttcatt????360ggaatcctct?agtcaggtgg?agcctggaac?agacaggaaa?tcaactgggt?ttgaaactct????420ggtggtgacc?tccgaagatg?gcatcacaaa?gatcatgttc?aaccggccca?aaaagaaaaa????480tgccataaac?actgagatgt?atcatgaaat?tatgcgtgca?cttaaagctg?ccagcaanga????540tgactcaatc?atcacttgtt?ttaacaggaa?atggtgacta?ttacagtagn?g?????????????591

<210>319

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>319gaattcggca?cgaggttgct?gctaagcgaa?cgccctttgg?agcttacgga?ggccttctga?????60aagacttcac?tgctactgac?ttgtctgaat?ttgctgccaa?ggctgccttg?tctgctggca????120aagtctcacc?tgaaacagtt?gacagtgtga?ttatgggcaa?tgtcctgcag?agttcttcag????180atgctatata?tttggcaagg?catgttggtt?tgcgtgtggg?aatcccaaag?gagaccccag????240ctctcacgat?taataggctc?tgtggttctg?gttttcagtc?cattgtgaat?ggatgtcagg????300aaatttgtgt?taaagaagct?gaagttgttt?tatgtggagg?aaccgaaagc?atgagccaag????360ctccctactg?tgtcagaaat?gtgcgttttg?gaaccaagct?tggatcagat?atcaagctgg????420aagattcttt?atgggtatca?ttaacagatc?agcatgtcca?gctccccatg?gcaatgactg????480cagagaatct?tgctgtaaaa?cacaaaataa?gcagagaaga?atgtgacaaa?tatgccctgc????540agtcacagca?gagatggaaa?gctgctaatg?atgctggcta?ctttaatgat?g?????????????591

<210>320

<211>591

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(591)

＜223〉n=A, T, C or G

<400>320ggctccggcg?tctgcagggg?tcgccgagct?aacccgtggc?taggcgagtg?gggcggggcg?????60gccggcacca?tgtcgaggca?ggcgaaccgt?ggcaccgaga?gcaagaaaat?gagctctgag????120ctcttcaccc?tgacctatgg?tgccctggtc?acccagctat?gtaaggacta?tgaaaatgat????180gaagatgtga?ataaacagct?ggacaaaatg?ggctttaaca?ttggagtccg?gctgattgaa????240gatttcttgg?ctcggtcaaa?tgttgggagg?tgccatgact?ttcgggaaac?tgcggatgtc????300attgccaagg?tggcgttcaa?gatgtacttg?ggcatcactc?caagcattac?taattggagc????360ccagctggtg?atgaattctc?cctcattttg?gaaaataacc?ccttggtgga?ctttgtggaa????420cttcctgata?accactcatc?ccttatttat?tccaatctct?tgtgtggggt?gttgcgggga????480gctttggaga?tggtccagat?ggctngngga?ggcccaagtt?tgtccaggac?accctnaaag????540gagacgggng?tgacagaaat?ccggatgaga?ttcatcaggc?ggattganga?c?????????????591

<210>321

<211>260

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(260)

＜223〉n=A, T, C or G

<400>321ctgcttggct?ccacacgtgg?gccgccgtag?gtattccgac?cggtaattcc?tcctattggt?????60gtgcagcagc?cacattgaag?gatagagtgg?cagcagaggc?caaggatcgt?gagttgatgg????120agtttgctgc?tgaaaatgaa?gggaagtctg?ggggaggtct?ccacagcgta?gctgaggggg????180tgcggctaag?tccagagcct?ggcagggagg?gagtaaggga?cttagcaggg?gcggaggagt????240tctgcggngg?anaggagggg????????????????????????????????????????????????260

<210>322

<211>559

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(559)

＜223〉n=A, T, C or G

<400>322ttccacatga?catggagtgt?gaagctggat?gagcacatca?ttccactggg?aagcatggca?????60nttaacagca?tctcaaaact?gactnanctc?acccagtctt?ccatgtattc?acttcctaat????120gcacccactc?tggcanacct?gnaggacnat?acacatgaag?ncantgatga?tcagccagan????180aancctcact?ttgactctcg?canngtgata?tttgagctgg?attcatgcaa?tggnagtggg????240aaagtttgcc?ttgtctacaa?aagtgggaaa?ccagnattag?cagaanacac?tgagatctgg????300ttcctgnaca?nancgttata?ctggcatttt?ctcacanaca?cctttactgc?ctattaccgc????360ctgctcatca?cccacctggg?cctgccccag?tggcaatatg?ccttcccagc?tatggcatta????420gcccacaggc?caagcaatgg?ttcagcatgt?ataaacctat?cacctacaac?acaaacctgc????480tcacagaaga?naccgactcc?tttgtgaata?agctagatcc?canctnagtg?tttaagagca????540agaacaagat?cgttatccc?????????????????????????????????????????????????559

<210>323

<211>492

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(492)

＜223〉n=A, T, C or G

<400>323cctgtctccc?agccgtacca?gcgagggctc?ggccggcagc?gccgggctgg?ggggcggcgg?????60cgccggcgcc?ggagccgggg?tgggtgcagg?cggcggcggg?ggcagcggcg?cgagcagcgg????120cggcggggcc?ggggggctgc?aacccagcag?ccgcgctggc?ggcggccggc?cctccagccc????180cagcccgtcg?gtggtgagcg?agaaggagaa?ggaagagttg?gagcggctgc?agaaagagga????240ggaggagagg?aagaagaggc?tgcagctgta?tgtgttcgtg?atgcgctgca?tcgcctaccc????300ctttaatgcc?aagcagccca?ccgacatggc?tcgccggcag?cagaagatca?gcaaacagca????360gctgcagaca?gtcaaggacc?ggtttcaggc?tttcctcaat?ggggaaaccc?anatcatggc????420tgacgaagcc?ttcatgaacc?gctgtngcag?agttactatg?aggtgttcct?gaagaccacc????480cgtgtggccg?ca????????????????????????????????????????????????????????492

<210>324

<211>474

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(474)

＜223〉n=A, T, C or G

<400>324aatttcagca?acatacttct?caatttcttc?aggatttaaa?atcttgaggg?attgatctcg?????60cctcatgaca?gcaagttcaa?tgtttttgcc?acctgactga?accacttcca?ggagtgcctt????120gatcaccagc?ttaatggtca?natcatctgt?ttcaatggct?tcgtcagtat?agttcttctc????180cagnaactca?cgcactgact?tggcaccccg?gcctatggca?ttggccttcc?aggcatggta????240tgtgcccgag?gggtcagtct?gatagagcct?aggagtgcca?tcaaagtcga?aacccacgat????300gagggcagag?atgccaaacg?gcctgcgccc?attgctctgc?gtataacgct?gcttcanact????360ggcgatgtag?cgggtgatgt?actccacagt?gaccgggtcc?tccacagtca?gccggtggct????420ctggcactcc?acccgggccc?tgttgatgac?tatccttgca?tcggcggtga?ggcc??????????474

<210>325

<211>532

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(532)

＜223〉n=A, T, C or G

<400>325gaggagacag?gacagagcgt?ctggagaggc?aggaggacac?cgagttcccc?gtgttggcct?????60ccaggtcctg?tgcttgcgga?gccgtccggc?ggctgggatc?gagccccgac?aatgggcaac????120gcgcaggagc?ggccgtcaga?gactatcgac?cgcgagcgga?aacgcctggt?cgagacgctg????180caggcggact?cgggactgct?gttggacgcg?ctgctggcgc?ggggcgtgct?caccgggcca????240gagtacgagg?cattggatgc?actgcctgat?gccgagcgca?gggtgcgccg?cctactgctg????300ctggtgcagg?gcaagggcga?ggccgcctgc?caggagctgc?tacgctgtgc?ccagcgtacc????360gcgggcgcgc?cggaccccgc?ttgggactgg?cagcacgtgg?gtccgggcta?ccgggaccgc????420agctatgacc?ctccatgccc?aggccactgg?acgccggagg?cacccggctc?ggggaccaca????480tgccccgggt?tgcccagact?tcagaccctg?acgaggncgg?gggccctgag?gg????????????532

<210>326

<211>322

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(322)

＜223〉n=A, T, C or G

<400>326caaaattaac?atttttatta?aatcaagtta?aaaaaaatgt?tcagtgtana?aaagtcaaca?????60agggttttaa?caaaaccaaa?atataccttt?ttatacaata?tatgtatata?ttagcagcaa????120actacttctg?anattctctt?tcttttatgt?tcttctagtt?attttaaaga?aagcataaac????180aatgtatatt?agtatggaat?gtcagcaaat?ccactcttag?tcctttattc?tgtgatttgg????240gccttctaca?aaatactttg?tgattctcac?taatgaatat?taagaacata?cccaatttta????300actaaaaagt?agtgaaacag?tg?????????????????????????????????????????????322

<210>327

<211>387

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>327aaaaccgtgt?actattagcc?atggtcaacc?ccaccgtgtt?cttcgacatt?gccgtcgacg?????60gcgagccctt?gggccgcgtc?tcctttgagc?tgtttgcaga?caaggtccca?aagacagcag????120aaaattttcg?tgctctgagc?actggagaga?aaggatttgg?ttataagggt?tcctgctttc????180acagaattat?tccagggttt?atgtgtcagg?gtggtgactt?cacacgccat?aatggcactg????240gtggcaagtc?catctatggg?gagaaatttg?aagatgagaa?cttcatccta?aagcatacgg????300gtcctggcat?cttgtccatg?gcaaatgctg?gacccaacac?aaatggttcc?cagtttttca????360tctgcactgc?caagactgag?tggttgg????????????????????????????????????????387

<210>328

<211>502

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(502)

＜223〉n=A, T, C or G

<400>328agcagcccgg?cgcggccgcc?gcgccggcgg?gcggcaaggc?tccgggccag?catgggggct?????60tcgtggtgac?tgtcaagcaa?gagcgcggcg?agggtccacg?cgcgggcgag?aaggggtccc????120acgaggagga?gccggtgaag?aaacgcggct?ggcccaaggg?caagaagcgg?aagaagattc????180tgccgaatgg?gcccaaggca?ccggtcacgg?gctacgtgcg?cttcctgaac?gagcggcgcg????240agcagatccg?cacgcgccac?ccggatctgc?cctttcccga?gatcaccaag?atgctgggcg????300ccgagtggag?caagctgcag?ccaacggaaa?agcagcggta?cctggatgag?gccnagagag????360agaagcagca?gtacatgaag?gagctgcggg?cgtaccagca?gtctgaagcc?tataagatgt????420gcacggagaa?gatccaggag?aagaagatca?agaaagaaga?ctcgagctct?gggctcatga????480acactcttct?gaatggacac?aa?????????????????????????????????????????????502

<210>329

<211>463

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(463)

＜223〉n=A, T, C or G

<400>329caagttgcac?attttaattt?acaattttta?ccaataaaaa?ggattagttt?acaaaaaggg?????60aagtccttta?tacaaaataa?ggacaatttg?taaaganaat?ccactgtcat?gttttgcctt????120gtcaagtcaa?aactcaaata?gcttgttttg?gtaaaattat?tccagaaaca?taatccagac????180aaaatcaata?acgtcatcag?cttcctaacc?atgtttaana?ggaataactt?catgaacatt????240ttgccctgaa?ctgaanagtt?ctaaatactt?gtaaaccttt?aggaaaaaat?gactgctcgc????300aggcagcttg?actggtaaga?gggtacacca?nagactccgg?gtcactcact?gtcagaatat????360tcttatacat?acaatgagtc?tccacgcctg?tacaatgagt?gtcgtgcaac?ataattggag????420taatggcctc?taaaatttta?caagtaaact?ttattgnggc?ccc??????????????????????463

<210>330

<211>500

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(500)

＜223〉n=A, T, C or G

<400>330taattataga?tctacaaaat?atgaaatgta?ttccaagaat?gcagaaaaac?catctagaag?????60caaaaggact?ataaaacaaa?aacagagaag?aaaattcatg?gctaaaccag?ctgaagaaca????120gcttgatgtg?ggacagtcta?aagatgaaaa?catacataca?tcacatatta?cccaagacga????180atttcaaaga?aattcagaca?gaaatatgga?agagcatgaa?gagatgggaa?atgattgtgt????240ttccaaaaaa?acagatgcca?cctgtgggaa?gcaagaaaag?tagcactaga?aaagataagg????300aagaatctaa?aaagaagcgc?ttttccagtg?agtccaagaa?caaacttgtn?cctgaagaag????360tgacttcaac?tgtcacgaaa?agtcgaanaa?tttccangcg?tccatctgat?tggtgggtgg????420taaaancaga?ggagagtcct?gtttatagca?attcttcagt?aagaaatgaa?ttaccaantg????480catcacaatn?ntgcccggaa????????????????????????????????????????????????500

<210>331

<211>494

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(494)

＜223〉n=A, T, C or G

<400>331tctctctctc?tctcaaaatt?acagtgttca?ttgtcattga?cctcagcagc?aaatttgact?????60tgaattcact?taggatcgca?ggaatcaggg?gaaagtgatt?ttaaaggtgg?tttctccagc????120acattttaag?aaaagggacc?aaaagttatt?ttagcttcct?caatagattg?catgttgctt????180attaggataa?taaattaata?ttaaatgcaa?tatatgtctt?gnctttatta?tggcatctat????240ttaggagttg?ttcaaatcac?tgcagtaggg?ctctgcaaat?aaaataatgn?aacctattat????300catggatcta?atgnactgna?actttatcag?tgaaaggnaa?aatctcaaat?aacaagtaca????360aacattggac?aattacctat?aaagatttgt?aaaaggaaaa?tttttccata?gatttcattc????420ttggcatttt?gtaaagacga?ccctgcagnc?ccctgtttgn?aactttttta?ataaaataga????480catctgttta?cttg??????????????????????????????????????????????????????494

<210>332

<211>538

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>332aaagaacaaa?tggaacgcga?tggttgttct?gaacaagagt?ctcaaccgtg?tgcatttatt?????60gggataggaa?atagtgacca?agaaatgcag?cagctaaact?tggaaggaaa?gaactattgc????120acagccaaaa?cattgtatat?atctgactca?gacaagcgaa?agcacttcat?gttgtctgta????180aagatgttct?atggcaacag?tgatgacatt?ggtgtgttcc?tcagcaagcg?gataaaagtc????240atctccaaac?cttccaaaaa?gaagcagtca?ttgaaaaatg?ctgacttatg?cattgcctca????300ggaacaaagg?tggctctgtt?taatcgacta?cgatcccaga?cagttagtac?cagatacttg????360catgtagaag?gaggtaattt?tcatgccagt?tcacagcagt?ggggagcctt?ttttattcat????420ctcttggatg?atgatgaatc?agaaggagaa?gaattcacag?tccgagatgg?ctacatccat????480tatggacaaa?cagtcaaact?tgtgtgctca?gttactggca?tggcactccc?aagattga??????538

<210>333

<211>499

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>333ctcagcctgc?gggactgctc?ggctcggctt?ctaggcggtt?ttgatgaaca?cctggcttta?????60ttcttgcaat?gaagaaaggt?tctcaacaaa?aaatattctc?caaagcaaag?ataccatcat????120catctcactc?tcctatccca?tcatctatgt?ccaatatgag?atctaggtca?ctttcacctt????180tgattggatc?agagactcta?ccttttcatt?ctggaggaca?gtggtgtgag?caagttgaga????240ttgcagatga?aaacaatatg?cttttggact?atcaagacca?taaaggagct?gattcacatg????300caggagttag?atatattaca?gaggccctca?ttaaaaaact?tactaaacag?gataatttgg????360ctttgataaa?atctctgaac?ctttcacttt?ctaaagacgg?tggcaagaaa?tttaagtata????420ttgagaattt?ggaaaaatgt?gttaaacttg?aagtactgaa?tctcagctat?aatctaatag????480ggaagattga?aaagtcgga?????????????????????????????????????????????????499

<210>334

<211>561

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(561)

＜223〉n=A, T, C or G

<400>334ttcccggtag?ttcagctgca?catgaataga?acagcaatga?gagccagtca?gaaggacttt?????60gaaaattcaa?tgaatcaagt?gaaactcttg?aaaaaggatc?caggaaacga?agtgaagcta????120aaactctacg?cgctatataa?gcaggccact?gaaggacctt?gtaacatgcc?caaaccaggt????180gtatttgact?tgatcaacaa?ggccaaatgg?gacgcatgga?atgcccttgg?cagcctgccc????240aaggaagctg?ccaggcagaa?ctatgtggat?ttggtgtcca?gtttgagtcc?ttcattggaa????300tcctctagtc?aggtggagcc?tggaacagac?aggaaatcaa?ctgggtttga?aactctggtg????360gtgacctccg?aagatggcat?cacaaagatc?atgttcaacc?cggcccaaaa?agaaaaatgc????420cataaacact?gagatgtatc?atgaaattat?gcgtgcactt?aaagctgcca?gcaaggatga????480ctcaatcatc?actgttttaa?cangaaatgg?tgactattac?agtagtggga?atgatctgac????540taacttcnct?gatattcccc?c??????????????????????????????????????????????561

<210>335

<211>551

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>335aagctggtca?tggctgggga?gaccaccaac?tcccgcggcc?agcggctgcc?ccagaaggga?????60gacgtggaga?tgctgtgcgg?cgggccgccc?tgccagggct?tcagcggcat?gaaccgcttc????120aattcgcgca?cctactccaa?gttcaaaaac?tctctggtgg?tttccttcct?cagctactgc????180gactactacc?ggccccggtt?cttcctcctg?gagaatgtca?ggaactttgt?ctccttcaag????240cgctccatgg?tcctgaagct?caccctccgc?tgcctggtcc?gcatgggcta?tcagtgcacc????300ttcggcgtgc?tgcaggccgg?tcagtacggc?gtggcccaga?ctaggaggcg?ggccatcatc????360ctggccgcgg?cccctggaga?gaagctccct?ctgttcccgg?agccactgca?cgtgtttgct????420ccccgggcct?gccagctgag?cgtggtgggt?ggatgacaag?aagtttgtga?gcaacataac????480caggttgagc?tcgggtcctt?tccggaccat?acggtgcgag?aaacgatgtc?cgacctgccg????540gaagtgcgga?a?????????????????????????????????????????????????????????551

<210>336

<211>540

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(540)

＜223〉n=A, T, C or G

<400>336aggtctatgt?ctactgaagg?caataaacga?ggaatgatcc?agcttattgt?tgcaaggaga?????60ataagcaagt?gcaatgagct?gaagtcacct?gggagccccc?ctggacctga?gctgcccatt????120gaaacagcgt?tggatgatag?agaacgaaga?atttcccatt?ccctctacag?tgggattgag????180gggcttgatg?aatcgcccag?cagaaatgct?gccctcagta?ggataatggg?taaataccag????240ctgtccccta?cagtgaatat?gccccaagat?gacactgtca?ttatagaaga?tgacaggttg????300ccagtgcttc?ctccacatct?ctctgaccag?tcctcttcca?gctcccatga?tgatgtgggg????360tttgtgacgg?cagatgctgg?tacttgggcc?aaggctgcaa?tcagtgattc?agccgactgc????420tctttgagtc?cagatgttga?tccagttctt?gcttttcaac?gaaaaaggat?ttggacgtca????480gaagtatgtc?agaaaaacgc?accaaagcaa?ttttcanatg?ccagtcaatt?ggatttcgtt????540

<210>337

<211>422

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(422)

＜223〉n=A, T, C or G

<400>337gcagcaggaa?cagttacagc?agcagcagca?acagcagctg?ttgcaacagc?agcaggaaca?????60atgtcagcag?caacaactgc?agcctcctcc?cctggagccc?gaggaggagg?aagaggtgga????120gctggagctc?atgccggtgg?acctggggtc?agagcaggag?ctggagcagc?agcggcagga????180gttggagcgg?cagcaggagc?tggaacggca?gcaggagcag?cggcagctgc?agctcaaact????240gcaggaggag?ctgcagcagc?tggagcaaca?gctggagcag?cagcagcagc?agctggagca????300gcaggaggtg?cagctggagc?tgaccccggt?ggagctaggc?gcccagcagc?aggaggtgca????360gctggagctg?acccccgtgc?agccggagct?gcagctggaa?ctggtgccan?cccagggggc????420gg???????????????????????????????????????????????????????????????????422

<210>338

<211>601

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(601)

＜223〉n=A, T, C or G

<400>338catcttacga?acgctctatg?atgtcttatg?agcggtctat?gatgtcccct?atggctgaac?????60gctctatgat?gtcagcctac?gagcgctcta?tgatgtcagc?ctacgagcgc?tctatgatgt????120cccctatggc?tgagcgctct?atgatgtcag?cttatgaacg?ctccatgatg?tcagcttatg????180aacgctccat?gatgtcccca?atggctgatc?gatctatgat?gtccatgggt?gctgaccggt????240ctatgatgtc?gtcatactct?gctgctgacc?ggtctatgat?gtcatcgtac?tctgcagctg????300accgatctat?gatgtcatct?tatactgctg?atcgttcaat?gatgtctatg?gctgctgatt????360cttacaccga?ttcttacact?gacacatata?cagaggcata?tatggtgcca?cctttgcctc????420ctgaagagcc?cccaacaatg?ccaccgttgc?cacctgagga?gccaccaatg?acaccaccat????480tgcctnctga?ggaaccaccc?agagggtcca?gcattgccca?cttgagcagt?cagcattaac????540cagcttgaaa?atacttggcc?ctacanangg?tgccatcatt?accatctgaa?gagctgtatc????600g????????????????????????????????????????????????????????????????????601

<210>339

<211>440

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(440)

＜223〉n=A, T, C or G

<400>339agagggagga?ggcccaactg?gtgatgctgc?tgctgctgct?gctgccgccg?ccgccgcctc?????60tattgctgat?actctagtgg?ggctggaagg?gtggttccta?ttcgcaccat?cgccaaccag????120agacagaggg?aaaaaaaaaa?ccggcagcca?ctgctgatgt?tgggttcgga?ggctgcatcc????180gactcggtca?caaggaaaat?ggattcagtt?tgcatctctc?cctcctttaa?acagcttctc????240cgggtctcag?catggtatca?aagcttgaaa?gagagaagac?tcaagaagcg?aagaggattc????300gtgagctgga?gcagcgcaag?cacacggtgc?tggtgacaga?actcaaagcc?aagctccatg????360aggagaagat?gaaggagctg?caggctgtga?gggagaacct?tatcaagcag?cacgacagga????420aatgtcaang?acggtgaagg????????????????????????????????????????????????440

<210>340

<211>450

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(450)

＜223〉n=A, T, C or G

<400>340gatttccagg?ggcggatatt?gagtgtcgac?ccagaggaag?aaagggagga?gggcccgcct?????60aggattcctc?aggccgacca?gtggaagtct?tcaaacaaga?gcctggtgga?ggctctgggg????120ctggaagccg?agggtgcagt?tcctgagaca?cagactttga?ccggatggag?taaggggttc????180attggcatgc?acagggaaat?gcaagtcaac?cccatttcaa?agcggatggg?gcccatgact????240gtggtcagga?tggacgcttc?agtccagcca?ggcccttttc?ggaccctgct?ccagtttctt????300tatacgggac?aactggatga?aaaggaaaag?gatttggtgg?gcctggctca?gatcgcagag????360gtcctcgaga?tgttcgattt?gaggatgatg?gtggaaaaca?tcatgaacaa?ggaagccttc????420atgaaccagg?agattacgaa?nncctttcac?????????????????????????????????????450

<210>341

<211>451

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>341aacagctatt?aaaacagaaa?atggatgaac?ttcataagaa?gttgcatcag?gtggtggaga?????60catcccatga?ggatctgccc?gcttcccagg?aaaggtccga?ggttaatcca?gcacgtatgg????120ggccaagtgt?aggctcccag?caggaactga?gagcgccatg?tcttccagta?acctatcagc????180agacaccagt?gaacatggaa?aagaacccaa?gagaggcacc?tcctgttgtt?cctcctttgg????240caaatgctat?ttctgcagct?ttggtgtccc?cagccaccag?ccagagcatt?gctcctcctg????300ttcctttgaa?agcccagaca?gtaacagact?ccatgtttgc?agtggccagc?aaagatgctg????360gatgtgtgaa?taagagtact?catgaattca?agccacagag?tggagcagag?atcaaagaag????420ggtgtgaaac?acataaggtt?gccaacacaa?g???????????????????????????????????451

<210>342

<211>498

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(498)

＜223〉n=A, T, C or G

<400>342ctcaagcagg?ctattgaaga?ggaaggaggc?gatccagata?atattgaatt?aactgtttca?????60actgatactc?caaacaagaa?accaactaaa?ggcaaaggta?aaaaacatga?agcagatgag????120ttgagtggag?atgcttctgt?gggaagatga?tgcttttatc?aaggactgtg?aattggagaa????180tcaagaggca?catgagcaag?atggaaatga?tgaactaaag?gactctgaag?aatttggtga????240aaatgaagaa?gaaaatgtgc?attccaagga?gttactctct?gcagaagaaa?acaagagagc????300tcatgaatta?atagaggcag?aaggaataga?agatatagaa?aaagaggaca?tcgaaagtca????360ggaaattgaa?gctcaagaag?gtgaagatga?tacctttcta?acagcccaag?atggtgagga????420agaagaaaat?gagaaagata?tagcagggtt?ctggtgatgg?cncacaagaa?gtatntaaac????480ctcttccttc?aaaaaggg??????????????????????????????????????????????????498

<210>343

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>343ccgaccccta?ctcggcggcg?caactccaca?accagtacgg?ccccatgaat?atgaacatgg?????60gtatgaacat?ggcagcagcc?gcggcccacc?accaccacca?ccaccaccac?caccccggtg????120cctttttccg?ctatatgcgg?cagcagtgca?tcaagcagga?gctaatctgc?aagtggatcg????180accccgagca?actgagcaat?cccaagaaga?gctgcaacaa?aactttcagc?accatgcacg????240agctggtgac?acacgtctcg?gtggagcacg?tcggcggccc?ggagcagagc?aaccacgtct????300gcttctggga?ggagtgtccg?cgcgagggca?agcccttcaa?ggccaaatac?aaactggtca????360accacatccg?cgtgcacaca?ggcgagaaac?ccttccctgc?ccttccgggt?gtggcaaagt????420cttcgcgcgc?tccgagaacc?tcaagatcca?caaaaggacc?acacagggga?gaagccgtcc????480agtggagttg?a?????????????????????????????????????????????????????????491

<210>344

<211>412

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(412)

＜223〉n=A, T, C or G

<400>344gtgcgctgtc?ttcccgcttg?cgtcagggac?ctgcccgact?cagtggccgc?catggcatca?????60gatgaaggca?aactttttgt?tggagggctg?agttttgaca?ccaatgagca?gtcgctggag????120caggtcttct?caaagtacgg?acagatctct?gaagtggtgg?ttgtgaaaga?cagggagacc????180cagagatctc?ggggatttgg?gtttgtcacc?tttgagaaca?ttgacgacgc?taaggatgcc????240atgatggcca?tgaatgggaa?gtctgtagat?ggacggcaga?tccgagtaga?ccaggcaggc????300aagtcgtcan?acaaccgatc?ccgtgggtac?cgtggtggct?ctgccggggg?ccggggcttc????360ttccgtgggg?gcccgangac?ggggcccgtg?ggttctctaa?aagaagaggg?ga????????????412

<210>345

<211>498

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>345aactagtctc?gggccatcct?ttctgcgcac?ccggtgtcgc?tgggctgcac?cccgggcggg?????60gacgtccgcc?gggcacggga?gggggccaag?atgccgatca?ataaatcaga?gaagccagaa????120agctgcgata?atgtgaaggt?tgttgttagg?tgccggcccc?tcaatgagag?agagaaatca????180atgtgctaca?aacaggctgt?cagtgtggat?gagatgaggg?gaactatcac?tgtacataag????240actgattctt?ccaatgaacc?tccaaagaca?tttacttttg?atactgtttt?tggaccagag????300agtaaacaac?ttgatgttta?taacttaact?gcaagaccta?ttattgattc?tgtacttgaa????360ggctacaatg?ggactatttt?tgcatatgga?caaaccggaa?caggcaaaac?ttttaccatg????420gaaaggtgtc?gagctattcc?tgaacttaga?ggaataattc?cccaatttct?ttgctcacaa????480tatttgggcc?atatttgc??????????????????????????????????????????????????498

<210>346

<211>427

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(427)

＜223〉n=A, T, C or G

<400>346agatggcggt?cgccgtgaga?actttgcagg?aacagctgga?aaaggccaaa?gagagtctta?????60agaacgtgga?tgagaacatt?cgcaagctca?ccgggcggga?tccgaatgac?gtgaggccca????120tccaagccag?attgctggcc?ctttctggtc?ctggtggagg?tagaggacgt?ggtagtttat????180tactgaggcg?tggattctca?gatagtggag?gaggaccccc?agccaaacag?agagaccttg????240aaggggcagt?cagtaggctg?ggcggggagc?gtcggaccag?aagagaatca?cgccaggaaa????300gcgacccgga?ggatgatgat?gttaaaaagc?cagcattgca?gtcttcannt?gtagctacct????360cccaaagagc?gccccacgta?gagaccttat?ccagggatca?aaattttgga?tgaaaaaggg????420gaaagcc??????????????????????????????????????????????????????????????427

<210>347

<211>280

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>347cacagaaagt?tctccgctcc?cagacatggg?tccctcggct?tcctgcctcg?gaagcgcagc?????60agcaggcatc?gtgggaaggt?gaagagcttc?cctaaggatg?acccgtccaa?gccggtccac????120ctcacagcct?tcctgggata?caaggctggc?atgactcaca?tcgtgcggga?agtcgacagg????180ccgggatcca?aggtgaacaa?gaaggaggtg?gtggaggctg?tgaccattgt?agagacacca????240cccatggtgg?ttgtgggcat?tgtgggctac?gtggaaaccc??????????????????????????280

<210>348

<211>411

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>348caactatgat?gtgcctgaaa?aatgggcacg?attctatact?gcagaagtag?ttcttgcatt?????60ggatgcaatc?cattccatgg?gttttattca?cagagatgtg?aagcctgata?acatgctgct????120ggataaatct?ggacatttga?agttagcaga?ttttggtact?tgtatgaaga?tgaataagga????180aggcatggta?cgatgtgata?cagcggttgg?aacacctgat?tatatttccc?ctgaagtatt????240aaaatcccaa?ggtggtgatg?gttattatgg?aagagaatgt?gactggtggt?cggttggggt????300atttttatac?gaaatgcttg?taggtgatac?acctttttat?gcagattctt?tggttggaac????360ttacagtaaa?attatgaacc?attaaaaatt?cacttacctt?tcctgatgat?a?????????????411

<210>349

<211>408

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>349gatgggcatc?tctcgggaca?actggcacaa?gcgccgcaaa?accgggggca?agagaaagcc?????60ctaccacaag?aagcggaagt?atgagttggg?gcgcccagct?gccaacacca?agattggccc????120ccgccgcatc?cacacagtcc?gtgtgcgggg?aggtaacaag?aaataccgtg?ccctgaggtt????180ggacgtgggg?aatttctcct?ggggctcaga?gtgttgtact?cgtaaaacaa?ggatcatcga????240tgttgtctac?aatgcatcta?ataacgagct?ggttcgtacc?aagaccctgg?tgaagaattg????300catcgtgctc?atcgacagca?caccgtaccg?acagtggtac?gagtcccact?atgcgctgcc????360cctgggccgc?aagaagggag?ccaaactgac?ttctgaggaa?gaagaaaa?????????????????408

<210>350

<211>409

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>350ggttccccca?gctctgggta?cccggctctg?catcgcgtcg?ccatgatggg?ccatcgtcca?????60gtgctcgtgc?tcagccagaa?cacaaagcgt?gaatccggaa?gaaaagttca?atctggaaac????120atcaatgctg?ccaagactat?tgcagatatc?atccgaacat?gtttgggacc?caagtccatg????180atgaagatgc?ttttggaccc?aatgggaggc?attgtgatga?ccaatgatgg?caatgccatt????240cttcgagaga?ttcaagtcca?gcatccagcg?gccaagtcca?tgatcgaaat?tagccggacc????300caggatgaag?aggttggaga?tgggaccaca?tcagtaatta?ttcttgcagg?ggaaatgctg????360tctgtagctg?agcacttcct?ggagcagcag?atgcacccaa?caggtgggg????????????????409

<210>351

<211>226

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>351aatcccaaac?atataactga?actcctcaca?cccaattgga?ccaatctatc?accctataga?????60agaactaatg?ttagtataag?taacatgaaa?acattctcct?ccgcataagc?ctgcgtcaga????120ttaaaacact?gaactgacaa?ttaacagccc?aatatctaca?atcaaccaac?aagtcattat????180taccctcact?gtcaacccaa?cacaggcatg?ctcataagga?aaggtt???????????????????226

<210>352

<211>410

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>352gcggaggggc?tggctgggca?ggaggggttg?gcggggcagc?agggccgcgg?ccatggggag?????60cttgaaggag?gagctgctca?aagccatctg?gcacgccttc?accgcactcg?accaggacca????120cagcggcaag?gtctccaagt?cccagctcaa?ggtcctttcc?cataacctgt?gcacggtgct????180gaaggttcct?catgacccag?ttgcccttga?agagcacttc?agggatgatg?atgagggtcc????240agtgtccaac?cagggctaca?tgccttattt?aaacaggttc?attttggaaa?aggtccaaga????300caactttgac?aagattgaat?tcaataggat?gtgttggacc?ctctgtgtca?aaaaaaacct????360cacaaagaat?cccctgctca?ttacagaaga?agatgcattt?aaaatatggg???????????????410

<210>353

<211>380

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(380)

＜223〉n=A, T, C or G

<400>353gagtttattt?agaaagtatc?atagtgtaaa?caaacaaatt?gtaccacttt?gattttcttg?????60gaatacaaga?ctcgtgatgc?aaagctgaag?ttgtgtgtac?aagactcttg?acagttgtgc????120ttctctagga?ggntgggttt?ttttaaaaaa?agaattatct?gngaaccata?cgtgattaat????180aaagatttcc?tttaaggcan?aggctggtcn?agatgctgct?gttatcttct?gcctcagaca????240gacagtataa?gnggtcttgt?ttctaagatt?cctaccacca?gttactttgg?gccaagtatc????300cacatcccct?tgcgtatggg?aggngggtga?anagtgttgg?atgcaaagng?gttattatgg????360gaagnagctc?natggtaaaa????????????????????????????????????????????????380

<210>354

<211>379

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(379)

＜223〉n=A, T, C or G

<400>354caacacatct?ttattaaaca?cctgaagtta?ctgggaggag?gccatgatgc?tggacacact?????60gtcaaagtca?atcttctcca?caatgttctt?gggtttaatg?ctctcttctt?ggctacagan????120gaanatctgc?cccgactngt?cggcactcca?gccgtatttg?ctcatccaca?cctttagctg????180gctgtccgac?aganccccga?gcatntcggc?cagcagccan?cggncaatgt?gctggtaagt????240gatacccaca?acatggcaga?taaactttcg?gacanagtct?tcaaagccag?ttataccttc????300caagaggtcc?atgttttcat?ccagggcttg?ccanaagcct?ggaaatggca?ggtctccaac????360aggtccccca?ggtacaaaa?????????????????????????????????????????????????379

<210>355

<211>499

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(499)

＜223〉n=A, T, C or G

<400>355gtccagagct?gctggtgctc?ccgttcccca?gaccctaccc?ctatccccag?tggagccgga?????60gtgcgggcgc?gccccaccac?cgccctcacc?atggtgctgt?tggcagcagc?ggtctgcaca????120aaagcaggaa?aggctattgt?ttctcgacag?tttgtggaaa?tgacccgaac?tcggattgag????180ggcttattag?cagcttttcc?aaagctcatg?aacactggaa?aacaacatac?gtttgttgaa????240acagagagtg?taagatatgt?ctaccagcct?atggagaaac?tgtatatggt?actgatcact????300accaaaaaca?gcaacatttt?agaagatttg?gagaccctaa?ggctcttctc?aagagtgatc????360cctgaatatt?gcgagcctta?gaagagaatg?aaatatctga?gcactgnttt?gatttgattt????420ttgcttttga?tgaaaatgtc?gcactgggat?acccgggang?aatgttaact?tggcacagat????480canaaccttt?cacagaaaa?????????????????????????????????????????????????499

<210>356

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>356gggcttctgc?tgagggggca?ggcggagctt?gaggaaaccg?cagataagtt?tttttctctt?????60tgaaagatag?agattaatac?aactacttaa?aaaatatagt?caataggtta?ctaagatatt????120gcttagcgtt?aagtttttaa?cgtaatttta?atagcttaag?attttaagag?aaaatatgaa????180gacttagaag?agtagcatga?ggaaggaaaa?gataaaaggt?ttctaaaaca?tgacggaggt????240tgagatgaag?cttcttcatg?gagtaaaaaa?tgtatttaaa?agaaaattga?gagaaaggac????300tacagagccc?cgaattaata?ccaatagaag?ggcaatgctt?ttagattaaa?atgaaggtga????360cttaaacagc?ttaaagttta?ntttaaaagt?tgtaggtgat?taaaataatt?tgaaggcgat????420cttttaaaaa?gagattaaac?ccgaaggtga?ttaaaagacc?ttgaaatcca?tgacgccagg????480gagaattgcc?gtcatttaaa?gcctagttaa?c???????????????????????????????????511

<210>357

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>357gatacttcac?atttccctag?ggacgggagc?ccgaggggtc?cgttcggccc?tcttcctctc?????60gctgggccga?caccccgctg?taggaccgta?acccttagtc?ccaatgcctc?cgtaagcgga????120gttgagtggg?tgcctgtggt?tggagctgtg?gaggtgtccc?cggtggcgag?cgcggccaga????180actgcggtca?cttaagtttt?ccgtgtgcgg?gttgcaagga?gcgtgcgtgc?gtctggtata????240atttggcttc?ctgagattct?gcttacaaga?aaggagtggg?aaataccctt?ggaaagaaaa????300ctaaaacagt?aagaaaacca?aaacttattt?ttacatggnt?gtcagcacat?ttaccgatat????360ggacactttt?cccaataatt?tcctcctggt?ggagacagtg?gattgacagg?ttctcagtcg????420gaattccaga?aaaatgttaa?ttgatgaaaa?gggtacnatg?tgagcatcat?aaagntaatt????480attaanacac?tgaaggctga?acacacaagg?g???????????????????????????????????511

<210>358

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(401)

＜223〉n=A, T, C or G

<400>358acggatgaag?atgatgacct?tcaagaaaat?gaagacaata?aacaacataa?agaaagcttg?????60aaaagagtga?cctttgcttt?accagatgat?gcggaaactg?aagatacagg?tgttttaaat????120gtaaagaaaa?attctgatga?agttaaatcc?tcctttgaaa?aaagacagga?aaagatgaat????180gaaaaaattg?catctttaga?aaaagagttg?ttagaaaaaa?agcccgtggc?agcttcaggg????240ggaagtgaca?gcacagaaga?ggccagagaa?cacctcctgg?aggagaccct?acctttgcca????300tctgcccgat?ggccctgtga?ttacagagga?acccccttca?ctggagattt?ctttaacnga????360ngatagagat?cngnttggga?tatgtntcct?taagaaaacc?t????????????????????????401

<210>359

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>359gcgatgcccg?cgcgcccagg?acgcctcctc?ccgctgctgg?cccggccggc?ggccctgact?????60gcgctgctgc?tgctgctgct?gggccatggc?ggcggcgggc?gctggggcgc?ccgggcccag????120gaggcggcgg?cggcggcggc?ggacgggccc?cccgcggcag?acggcgagga?cggacaggac????180ccgcacagca?agcacctgta?cacggccgac?atgttcacgc?acgggatcca?gagcgcccgc????240gcacttcgtc?atgttcttcg?cgccctggtg?tggacacttg?ccagcggctt?gcagccgant????300ttggaatgac?cttggganga?acaaatacaa?cagcatggaa?agaatgccaa?aagtctatgt????360ggnttaaagt?ggacttgcac?nggccacttc?gactngtgct?cccccaaggg?gngggaagat????420acccacctta?aaacttttca?accaagccaa?aaactttgaa?aaccaggtct?cggattcaaa????480atggaaaact?gatgttcaac?ctgaacaaga?a???????????????????????????????????511

<210>360

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>360tactgggaga?ctttgagatt?gagtccaaac?agctggaagc?agagtcttgg?agtcggataa?????60tagacagcaa?gtttctaaaa?cagcaaaaga?aagatgtggt?caaacggcaa?gaagtaatat????120atgagttgat?gcagacagag?tttcatcatg?tcccgactct?caagatcatg?agtggtgtgt????180cnagccnggg?gatgatggcg?gatctgnttt?ttgagcanca?gatggtagaa?aaagctggtt????240ccctgtttgg?atgagcttga?tcagtatccc?atacccattc?tttccagagg?attcttggag????300ccggaaagaa?nggagtcttc?ttggtgggat?aaaaagtgaa?aaagaacttt?ctcttcaana????360aggatagggg?gatgtgcttt?gtaaaatcan?tttttcaggg?ngganaatgc?cnnaaccgtt????420ttaaagaaaa?acatnttggg?naagtttttg?tgggccaaca?ttacccggtc?ttgtaaacct????480accttcaaag?aacctttttg?cccagggtta?a???????????????????????????????????511

<210>361

<211>411

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(411)

＜223〉n=A, T, C or G

<400>361gctcagcggc?ccgatcccac?ggaagcgcgc?tcggaggggt?gggacccggc?cggaccggag?????60atggcgccgc?cagcgggcgg?ggcggcggcg?gcggcctcgg?acttgggctc?cgccgcagtg????120ctcttggctg?tgcacgccgc?ggtgaggccg?ctgggcgccg?ggccagacgc?cgaagcacaa????180cttgcggagg?ctgcagctta?acgcggaccc?tgagaagcct?ggcgcttncn?gctggaactt????240cttggcgcgg?gacctggggc?ggtaatttga?gtggccctga?gtcatttcta?caccatccag????300gcccaccaca?cgactaagct?cacaagaagg?ctgaactnnc?tgattctnaa?cctagaanta????360cgtgcatcta?tcagtgccng?aagaaatgac?aacataccac?tggcaactct?g?????????????411

<210>362

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

<400>362cgggggaccg?ggctgccttg?gcccctcagc?gctcgcgtct?tttccggcag?ttggaacgct?????60tcctgttgtc?ctcacccgta?accgcctgtt?gccccctgtc?tcagagtccc?tcacgcgtcc????120cctcccgtct?ttggctcgtt?ggctgccgcc?gccggggctt?cgccagcctt?caagtcgaga????180ctactggccg?aaggggcgtc?tgcggctctc?cgccgtcccc?agccctgcct?ctccctgggc????240tctgccatgg?caatgacagg?ctcaacacct?tgctcatcca?tgagtaacca?cacaaaggaa????300agggtgacaa?tgaccaaaag?tgacactgga?gaatttttat?agcaacctta?tcgctcacat????360gaagaacgag?aaatgagaca?aaagaagtta?gaaaaagggg?atggaagaag?aaggcctaaa????420aaaatgaagg?agaaaaccaa?cttccgaaga?tcaaccacat?tgcttcggaa?anggaaacaa????480aantttcttt?cgtttgaaan?aaaaacaaan?a???????????????????????????????????511

<210>363

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>363caggatctgg?ggagaaagag?ccccatccct?tctctctctg?ccaccatttc?ggacaccccg?????60cagggactcg?ttttgggatt?cgcactgact?tcaaggaagg?acgcgaaccc?ttctctgacc????120ccagctcggg?cggccacctg?tctttgccgc?ggtgaccctt?ctctcatgac?cctgcggtgc????180cttgagccct?ccgggaatgg?cggggaaggg?acgcggagcc?agtgggggac?cgcggggtcg????240gcggaggagc?catccccgca?ggcggcgcgt?ctggcgaagg?ccctgcggga?gctcggtcag????300acaggatggt?actggggaag?tatgactgtt?aatgaagcca?aagagaaatt?aaaagaggca????360ccagaaggaa?ctttcttgat?tagagatagc?tcgcattcag?a????????????????????????401

<210>364

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>364agtcaaaggt?ttcttttccc?tttttaccat?ggtttctaca?aaaataacct?tcaggaaaaa?????60gaaaatcagg?aaaaaaattt?tttttcaata?atcttattcc?ctatattaaa?ttagatttga????120agaggattaa?cgttgtttta?gtttgggtcc?agatcagcct?tatacaacat?ttctaaactc????180atttgtactt?ttaaaaaatt?taaacacaga?cttctaaaat?tacttgatgt?aagtaattta????240aatcacttat?gaccaagtta?ttaaccttat?gaatcagaag?tctgaccctt?gtaggaaatt????300atattcacat?ataaagtaca?tcagatcttt?gccatatatt?gatggttatt?atgcataaac????360acattgagtt?gtgttggaag?cagatttata?aacctgcatg?t????????????????????????401

<210>365

<211>361

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>365atctggagtt?gcacaaatag?ttctttagaa?cataaaacta?aatggattta?tacataacag?????60ttacattcag?catttaagag?aggcagtaca?aaaatgtgtt?ctgcttttat?ctgatataaa????120ttgcatgtaa?taccatgatt?taaacaatat?cagttatatt?aactaatgcc?atgagatata????180tcttactcag?aacgtctgat?gtttcccata?atagacagaa?aaaatgcagt?tgtatgagca????240actgagtttc?ttttcatctt?caaattcatt?tgtgatggtg?ggaagatcta?aggacaatcc????300ttccattgaa?gaagtaggaa?aaacagttca?gcactgttct?gaactcatca?aaaatgaaat????360t????????????????????????????????????????????????????????????????????361

<210>366

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>366cgggagcagc?agaggtctag?cagccgggcg?ccgcgggccg?ggggcctgag?gaggccacag?????60gacgggcgtc?ttcccggcta?gtggagcccg?gcgcggggcc?cgctgcggcc?gcaccgtgag????120gggaggaggc?cgaggaggac?gcagcgccgg?ctgccggcgg?gaggaagcgc?tccaccaggg????180cccccgacgg?cactcgttta?accacatccg?cgcctctgct?ggaaacgctt?gctggcgcct????240gtcaccggtt?ccctccattt?tgaaagggaa?aaaggctctc?cccacccatt?cccctgcccc????300taggagctgg?agccggagga?gccgcgctca?tggcgttcag?cccgtggcag?atcctgtccc????360ccgtgcagtg?ggcgaaatgg?acgtggtctg?cggtacgcgg?c????????????????????????401

<210>367

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>367catggagtcg?ggcaagatgg?cgcctcccaa?gaacgctccg?agagatgcct?tggtgatggc?????60acagatcctg?aaggatatgg?gaatcacaga?gtatgaacca?agggttataa?atcaaatgtt????120ggaatttgct?ttccgttatg?tgactacaat?tctggatgat?gcaaaaattt?attcgagcca????180tgctaagaaa?cctaatgttg?atgcagatga?tgtgagactg?gcaatccagt?gtcgtgctga????240ccaatctttt?acctctcctc?ccccaagaga?ttttttactg?gatatcgcaa?ggcagaaaaa????300tcaaacccct?ttgccactga?ttaagccata?tgcaggacct?agactgccac?ctgatagata????360ctgcttaaca?gctccaaact?ataggctgaa?gtccttaatt?a????????????????????????401

<210>368

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>368cggagcggta?ggagcagcaa?tttatccgtg?tgcagcccca?aactggaaag?aagatgctaa?????60ttaaagtgaa?gacgctgacc?ggaaaggaga?ttgagattga?cattgaacct?acagacaagg????120tggagcgaat?caaggagcgt?gtggaggaga?aagagggaat?ccccccacaa?cagcagaggc????180tcatctacag?tggcaagcag?atgaatgatg?agaagacagc?agctgattac?aagattttag????240gtggttcagt?ccttcacctg?gtgttggctc?tgagaggagg?aggtggtctt?aggcagtgat????300ggaccctcca?ttttacctct?ttaccctgtc?gctcataatg?aggcatcata?tatcctctca????360ctctctggga?caccatagcc?ctgccccctc?ccctggatgc?c????????????????????????401

<210>369

<211>174

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(174)

＜223〉n=A, T, C or G

<400>369gcgagnnggg?cgccaagcgc?ggggccggag?cggccttccc?ggagtccttt?gcgcggcacc?????60tggcgacaaa?atggctgccc?gagggagacg?ggcggagcct?cagggccggg?aggctccggg????120ccccgcgggc?ggtggcggtg?gcgggagccg?ttgggctgag?tcgggatcgg?ggac??????????174

<210>370

<211>375

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(375)

＜223〉n=A, T, C or G

<400>370tgcttttcca?actttattta?gaaaaacaaa?tccaggtccc?agtgccccct?gtaccctccc?????60cgaccccagc?cataatttaa?ataacttana?gacagagttg?gagggagggg?acagganagg????120ttggggtcac?ggtggaagga?ggaaganagc?ccactacagc?cgccgcagcg?cccgcttctt????180gtccgtcttt?ttcttggccg?ccagcttctt?atcgcgctcg?ccagcatgct?tnttggccat????240gggaccctca?gcccctcccg?ggccccctgg?ggccccaggg?tcggtggagg?aagcttcagt????300gccactggcc?agggcccgac?cggcttcggc?cctgccgctg?ggcccgccgg?cgcccccgtg????360gatctctgtg?agcag?????????????????????????????????????????????????????375

<210>371

<211>375

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(375)

＜223〉n=A, T, C or G

<400>371taaattctaa?aaaatatttt?aatacttgaa?aacttctaaa?acaaaaggta?aggtaacatg?????60ttctttcaaa?agtgaatttc?acatgcaaac?cattaattat?atttatttta?ctgngagata????120aaagcaaaac?ataacattcg?gagaaagaga?ccagtaactg?acctatttat?tttatattat????180attaatgnga?atcctcatta?gaaatgtgat?aacgttattg?cacaaacaaa?accgtgggca????240gaaacatccc?agcaatgcag?gggcgcccat?accgggttac?aagggatgtc?cagcatgtgt????300ttccctggaa?cactcanagt?ctgcactttt?cctgcaaatg?ggaccatgtc?tgattattta????360ttatgaaaga?acact?????????????????????????????????????????????????????375

<210>372

<211>164

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(164)

＜223〉n=A, T, C or G

<400>372cgctctgtnt?cctcaacctc?tacctggcgg?aggttatatg?taaagtcaga?tgtgccactg?????60aacttgacag?acacaaaatt?ctactgcatt?tgggctttat?aatggcaagc?ctgctctttt????120tagtggtgaa?cttgacttgc?gcaatgctag?ttcatggaga?tgtc?????????????????????164

<210>373

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>373gcgctgttcg?cctttgccta?cctgcagctg?tggcggctgc?tcctgtaccg?cgagcggcgg?????60ctgagttacc?agagcctctg?cctcttcctc?tgtctcctgt?gggcagcgct?caggaccacc????120ctcttctccg?ccgccttctc?gctcagcggc?tccctgccct?tgctccggcc?gcccgctcac????180ctgcacttct?tcccccactg?gctgctctac?tgcttcccct?cctgtctcca?gttctccacg????240ctctgtctcc?tcaacctcta?cctggcggag?gttatatgta?aagtcagatg?tgccactgaa????300cttgacagac?acaaaattct?actgcatttg?ggctttataa?tggcaagcct?gctcttttta????360gtggtgaact?tgacttgcgc?aatgctagtt?catggagatg?t????????????????????????401

<210>374

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>374ggaatgatac?cattcagatt?gatttggaga?ctggcaagat?tactgatttc?atcaagttcg?????60acactggtaa?cctgtgtatg?gtgactggag?gtgctaacct?aggaagaatt?ggtgtgatca????120ccaacagaga?gaggcaccct?ggatcttttg?acgtggttca?cgtgaaagat?gccaatggca????180acagctttgc?cactcgactt?tccaacattt?ttgttattgg?caagggcaac?aaaccatgga????240tttctcttcc?ccgaggaaag?ggtatccgcc?tcaccattgc?tgaagagaga?gacaaaagac????300tggcggccaa?acagagcagt?gggtgaaatg?ggtccctggg?tgacatgtca?gatctttgta????360cgtaattaaa?aatattgtgg?caggattaat?agcaaaaaaa?a????????????????????????401

<210>375

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>375gagcggagtc?cgctggctga?cccgagcgct?ggtctccgcc?gggaaccctg?gggcatggag?????60aggtctgagt?acctcggccg?cggcgcacgc?tgcatcgcgg?agccaggccg?aggacgtgag????120ggtggagggc?tcctttcccg?tgaccatgct?tccgggagac?ggtgtggggc?ctgagctgat????180gcacgccgtc?aaggaggtgt?tcaaggctgc?cgctgtccca?gtggagttcc?aggagcacca????240cctgagtgag?gtgcagaata?tggcatctga?ggagaagctg?gagcaggtgc?tgagttccat????300gaaggagaac?aaagtggcca?tcattggaaa?gattcatacc?ccgatggagt?ataaggggga????360gctagcctcc?tatgatatgc?ggctgaggcg?taagttggac?t????????????????????????401

<210>376

<211>284

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(284)

＜223〉n=A, T, C or G

<400>376ggaacaaggt?cgtgaaaaaa?aaggtcttgg?tgaggtgccg?ccatttcatc?tgtcctcatt?????60ctctgcgcct?ttcgcagagc?ttccancagc?tggtatgttg?ggccagagca?tccggaggtt????120cacaacctct?gtggtccgta?ggagccacta?tgaggagggc?cctgggaaga?atttgccatt????180ttcagtggaa?aacaagtggt?cgttactagc?taagatgtgt?ttgtactttg?gatctgcatt????240tgctacaccc?ttccttgtan?taagacacca?actgcttaaa?acat?????????????????????284

<210>377

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>377atttatgtta?ttgcactctc?ggtgtgattt?atcgtatgta?tctgataggt?tttatgaatt?????60gttttgagtt?gtaaactcct?atacccttta?ttaaaatgga?cctaattaag?tgatttatgc????120tttgtgcaat?ttcttaaatc?agatctctct?aggattgaag?ggatccatag?gtatctttca????180cttagtgtga?agcctagtag?tatactttta?tattcctgaa?gagagaccag?cattaacata????240aagagagaag?tcttaggaaa?aaatatacct?aagaattatt?tttaaaattc?atactgtgaa????300ggagaatctg?cctgcctatt?tcctctccaa?atttcagaaa?ataacacaga?gtgctatttg????360cctgaacttt?aatgagcttg?actttgttat?gattcaggga?g????????????????????????401

<210>378

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>378ccagaacaca?ggtgtcgtga?aaactacccc?taaaagccaa?aatgggaaag?gaaaagactc?????60atatcaacat?tgtcgtcatt?ggacacgtag?attcgggcaa?gtccaccact?actggccatc????120tgatctataa?atgcggtggc?atcgacaaaa?gaaccattga?aaaatttgag?aaggaggctg????180ctgagatggg?aaagggctcc?ttcaagtatg?cctgggtctt?ggataaactg?aaagctgagc????240gtgaacgtgg?tatcaccatt?gatatctcct?tgtggaaatt?tgagaccagc?aagtactatg????300tgactatcat?tgatgcccca?ggacacagag?actttatcaa?aaacatgatt?acagggacat????360ctcaggctga?ctgtgctgtc?ctgattgttg?ctgctggtgt?t????????????????????????401

<210>379

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>379tcagatatca?ggtggcttct?tcaaatgatt?tttaagtatc?tcgatgatga?tgaagaacaa?????60agacatcaat?caggattcag?gaagacagct?tttgcggaaa?atgcttaaag?ggaagcatca????120aggattggtg?ttgatatttg?aaagtttaag?agtggtatac?ttttattcag?tcaacacatg????180acaaatgtaa?aaggcactca?tttgttgttc?ctggaagaag?cctggcagca?ttccattcag????240acatctgccc?tttcatcgtc?ccacttttta?cttattgcag?tcctttcagt?ctgaatattt????300cctcctgacg?catcttctgc?cgtccgaaat?gactccctgc?tcccagatcc?tgtagccctt????360attattgaca?cctttcattt?agaaatttag?cacatgtcac?a????????????????????????401

<210>380

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>380cctgactctc?tgaggctcat?tttgcagttg?ttgaaattgt?ccccgcagtt?ttcaatcatg?????60tctgaaccaa?tcagagtcct?tgtgactgga?gcagctggtc?aaattgcata?ttcactgctg????120tacagtattg?gaaatggatc?tgtctttggt?aaagatcagc?ctataattct?tgtgctgttg????180gatatcaccc?ccatgatggg?tgtcctggac?ggtgtcctaa?tggaactgca?agactgtgcc????240cttcccctcc?tgaaagatgt?catcgcaaca?gataaagaag?acgttgcctt?caaagacctg????300gatgtggcca?ttcttgtggg?ctccatgcca?agaagggaag?gcatggagag?aaaagattta????360ctgaaagcaa?atgtgaaaat?cttcaaatcc?cagggtgcag?c????????????????????????401

<210>381

<211>401

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(401)

＜223〉n=A, T, C or G

<400>381ggggcttcgc?tggcagtctg?aacggcaagc?ttgagcaacg?cggtaaaaat?attgcttcgg?????60tgggtgacgc?ggtacagctg?tccaagggcn?ttngtaacgg?gaatgccgaa?gcgtgggaaa????120aagggagcgg?tggcggaaga?cggggatgag?ctcaggacag?agccagaggc?caagaagagt????180aagacggccg?caaagaaaaa?tgacaaagag?gcagcaggag?agggcccagc?cctgtatgag????240gaccccccag?atcagaaaac?ctcacccagt?ggcaaacctg?ccacactcaa?gatctgctct????300tggaatgtgg?atgggcttcg?agcctggatt?aagaagaaag?gattagattg?ggtaaaggaa????360gaagccccag?atatactgtg?ccttcaagag?accaaatgtt?c????????????????????????401

<210>382

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>382gagcagcccc?cggcggctga?aagccggggc?agaagtgctg?gtctcggtcg?ggattccggg?????60cttggtccca?ccgaggcggc?gactgcggta?ggagggaaga?ggttttggac?gcgctggcct????120cccgccgctg?tgcattgcag?cattatttca?gttcaaaatg?aactatatgc?ctggcaccgc????180cagcctcatc?gaggacattg?acaaaaagca?cttggttctg?cttcgagatg?gaaggacact????240tataggcttt?ttaagaagca?ttgatcaatt?tgcaaactta?gtgctacatc?agactgtgga????300gcgtattcat?gtgggcaaaa?aatacggtga?tattcctcga?gggatttttg?tggtcagagg????360agaaaatgtg?gtcctactag?gagaaataga?cttggaaaag?gagagtgaca?cacccctcca????420gcaagtatcc?attgaagaaa?ttctagaaga?acaaagggtg?gaacagcaga?ccaagctgga????480agcagagaag?t?????????????????????????????????????????????????????????491

<210>383

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>383gagtccatct?cagcgcctgg?aaaatgcagt?gaaaaaacct?gaagataaaa?aggaagtttt?????60cagacccctc?aagcctgctg?gcgaagtgga?tctgaccgca?ctggccaaag?agcttcgagc????120agtggaagat?gtacggccac?ctcacaaagt?aacggactac?tcctcatcca?gtgaggagtc????180ggggacgacg?gatgaggagg?acgacgatgt?ggagcaggaa?ggggctgacg?agtccacctc????240aggaccagag?gacaccagag?cagcgtcatc?tctgaatttg?agcaatggtg?aaacggaatc????300tgtgaaaacc?atgattgtcc?atgatgatgt?agaaagtgag?ccggccatga?ccccatccaa????360ggagggcact?ctaatcgtcc?gccagagtac?agttgaccaa?aagcgtgcca?gccatcatga????420gagcaatggc?tttgccggtc?gcattcacct?cttgccagat?ctcttacagc?aaagccattc????480ctcctccact?t?????????????????????????????????????????????????????????491

<210>384

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>384gagcctaatc?tcaggtggtc?cacccgagac?cccttgagca?ccaaccctag?tcccccgcgc?????60ggccccttat?tcgctccgac?aaggtacaaa?aaggctctgg?acggcggcgt?ggtaggagga????120cgggagcggg?ggcgggaagt?tccctgaagg?agcgagacag?ggagggacag?ggcagaggag????180gagaggaagg?cgatgcgacg?gacaggcgca?cccgctcagg?ctgactctcg?ggggcgaggt????240cgagccaggg?gcggctgccc?tgggggcgag?gcgacgctgt?ctcaacctcc?acctcgcggc????300ggaacccgag?gacaggagcc?tcagatgaaa?gaaacaatca?tgaaccagga?aaaactcgcc????360aaactgcagg?cacaagtgcg?cattggtggg?aaaggaactg?ctcgcagaaa?gaagaaggtg????420gttcatagaa?cagccacagc?agatgacaaa?aaacttcagt?tctccttaaa?gaagttaggg????480gtaaacaata?t?????????????????????????????????????????????????????????491

<210>385

<211>483

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>385agccgctgcg?aagggagccg?ccgccatgtc?tgcgcatctg?caatggatgg?tcgtgcggaa?????60ctgctccagt?ttcctgatca?agaggaataa?gcagacctac?agcactgagc?ccaataactt????120gaaggcccgc?aattccttcc?gctacaacgg?actgattcac?cgcaagactg?tgggcgtgga????180gccggcagcc?gacggcaaag?gtgtcgtggt?ggtcattaag?cggagatccg?gccagcggaa????240gcctgccacc?tcctatgtgc?ggaccaccat?caacaagaat?gctcgcgcca?cgctcagcag????300catcagacac?atgatccgca?agaacaagta?ccgccccgac?ctgcgcatgg?cagccatccg????360cagggccagc?gccatcctgc?gcagccagaa?gcctgtgatg?gtgaagagga?agcggacccg????420ccccaccaag?agctcctgag?ccccctgccc?ccagagcaat?aaagtcagct?ggctttctca????480cct??????????????????????????????????????????????????????????????????483

<210>386

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>386aggtggaagg?aaaaaacata?aatgaagtta?atgcacttct?tttcctagcc?caaaagtcac?????60tgtgattata?tttttttaat?gaagtttaga?aaaaaagctg?ttgtcttctc?aattgtaaaa????120ttagtttcaa?aatgctgctt?ctcttatcat?tagtctagta?attgttgaac?ttttctgcaa????180actgcatttt?acaaaattga?aacttggaag?ctgtattaac?ttttatagtt?aaacattgta????240ttaaataaac?tatactataa?taaacagttt?ggttttgtat?tttttaaatt?gtattatcca????300gccttttaaa?aattaaaagc?taaataatga?aaataaacca?attaaaacat?acttttactc????360tcagatatac?aggtatttac?attatgaaaa?aactgaacaa?agttttaaca?atactgagct????420ttaagaattt?agccagcagg?gaaaatttcc?aggtttgaga?atgttctaat?gtaaatattt????480aatcataata?c?????????????????????????????????????????????????????????491

<210>387

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>387ccacaccacc?gtgtcccaag?tccagccccc?tccctccaag?gcatcagcac?ctgaaccccc?????60tgcagaagaa?gaagtggcaa?ctggtacaac?ctcagcctct?gatgacctgg?aagccctggg????120tacactgagc?ctggggacca?cagaggagaa?ggcagcagct?gaggcggctg?tgcccaggac????180cattggggcc?gagctgatgg?agctggtgcg?gagaaacact?ggcctgagcc?acgaattatg????240ccgggtggcc?atcggcatca?tagtgggtca?catccaggcc?tcggtgccgg?ccagctcacc????300agtcatggag?caggtcctcc?tctcactcgt?agagggcaag?gacctcagca?tggccctgcc????360??ctcagggcag?gtctgccacg?accagcagag?gctggaggtg?atctttgcag?acctggctcg????420ccggaaggac?gacgcccagc?agcgcagttg?ggcactatat?gaggatgagg?gtgtcatccg????480ctgctaccta?g?????????????????????????????????????????????????????????491

<210>388

<211>491

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<400>388gagactatca?aactcctgag?ccaacaactt?aatatgacta?gcttacacaa?tagcttttat?????60agtaaagata?cctctttacg?gactccactt?atgactccct?aaagcccatg?tcgaagcccc????120catcgctggg?tcaatagtac?ttgccgcagt?actcttgaaa?ctaggcggct?atggtataat????180acgcctcaca?ctcattctca?accccctgac?aaaacacata?gcctacccct?tccttgtact????240atccctatga?ggcataatta?taacaagctc?catctgccta?cgacaaacag?acctaaaatc????300gctcattgca?tactcttcaa?tcagccacat?agccctcgta?gtaacagcca?ttctcatcca????360aaccccctga?agcttcaccg?gcgcagtcat?tctcataatc?gcccacggac?ttacatcctc????420attactattc?tgcctagcaa?actcaaacta?cgaacgcact?cacagtcgca?tcataatcct????480ctctcaagga?c?????????????????????????????????????????????????????????491

<210>389

<211>511

<212>DNA

＜213〉homo sapiens (Homo sapiens)

<220>

<221>misc_feature

<222>(1)...(511)

＜223〉n=A, T, C or G

＜400〉389tactgatatc, tctttaatac, tttcatcatt, caagtttgtt, canaacatta, caagaggcat, 60gaaagaaaaa, ataattccat, ttttaaaact, ctgtctgtcc, aaagtataac, atatgaaacc, 120atgccattat, ctnttaggaa, acaaaagcat, tcaaaattaa, tttggtatta, aagttcaaga, 180ttcanactaa, cctcaaagta, cggcatgtgc, agtgtttaag, tgcaanaagt, attttcattc, 240caattatttt, acananatgc, tggagtgacg, tgtgcaattt, gaaatattca, aatcctttaa, 300ggnttctgaa, ctaagtgttt, aaatgaaaac, tgaaatgctg, catagtttca, gtggctttca, 360atttcctgtt, tgatctcaga, aatatatgga, tgatctttgc, cgtgagctac, ttccatgatt, 420gcaatggcct, tcttcagggc, tttctcccct, gcggctttgt, gttccaggcc, catgtagagt, 480ctccctagct, tcaaccacat, ggaggccacg, t, 511＜210〉390＜211〉1984＜212〉DNA＜213〉homo sapiens, (Homo, sapiens)＜400〉390cctggggtta, gaggctgggg, tgggtggggg, gtaagggggc, agtccttctc, cccttcgacg, 60gcggctccga, gtccagcccc, ttccttcccg, cgctcgctcg, cccggccccc, agccccctca, 120tgagggtgtc, cgtgccgggt, ccggcggccg, ctgccgcccc, cgcagccggc, cgcgagccct, 180ccacgcccgg, cgggggcagc, ggaggcggag, gcgccgtcgc, tgcagcctca, ggcgccgcgg, 240tgccgggctc, cgtgcagttg, gcgctgagcg, tcctgcacgc, cctgctctac, gccgcgctgt, 300tcgcctttgc, ctacctgcag, ctgtggcggc, tgctcctgta, ccgcgagcgg, cggctgagtt, 360accagagcct, ctgcctcttc, ctctgtctcc, tgtgggcagc, gctcaggacc, accctcttct, 420ccgccgcctt, ctcgctcagc, ggctccctgc, ccttgctccg, gccgcccgct, cacctgcact, 480tcttccccca, ctggctgctc, tactgcttcc, cctcctgtct, ccagttctcc, acgctctgtc, 540tcctcaacct, ctacctggcg, gaggttatat, gtaaagtcag, atgtgccact, gaacttgaca, 600gacacaaaat, tctactgcat, ttgggcttta, taatggcaag, cctgctcttt, ttagtggtga, 660acttgacttg, cgcaatgcta, gttcatggag, atgtcccaga, aaatcagttg, aagtggactg, 720tgtttgttcg, agcattaatt, aatgatagcc, tgtttattct, ttgtgccatc, tctttagtgt, 780gttacatatg, caaaattaca, aaaatgtcat, cagctaatgt, ctacctcgaa, tcaaagggta, 840tgtctctgtg, ccagactgtc, atcgtgggct, ctgtagtcat, tcttctgtac, tcttccagag, 900cttgttataa, tttggtggtg, gtcaccatat, ctcaggatac, attagaaagt, ccatttaatt, 960atggctggga, taatctttca, gataaggctc, atgtagaaga, cataagtgga, gaagagtata, 1020tagtatttgg, aatggtcctc, tttctgtggg, aacatgtgcc, agcatggtcg, gtggtactgt, 1080ttttccgggc, acagagatta, aaccagaatt, tggcacctgc, tggcatgata, aatagtcaca, 1140gttatagttc, cagagcttac, tttttcgaca, atccaagacg, atatgatagt, gatgatgacc, 1200tgccaagact, gggaagttca, agagaaggaa, gtttaccaaa, ttcgcaaagt, ttgggctggt, 1260atggcaccat, gactgggtgt, ggcagcagca, gttacacagt, cactccccac, ctgaatggac, 1320ctatgacaga, tactgctcct, ttgctcttta, cttgtagtaa, tttagatttg, aacaatcatc, 1380atagcttata, tgtgacacca, caaaactgac, agcatcacca, agtcatgatt, cttgagttgt, 1440ttttcataaa, tgtgtatatt, caatgtgttt, aaattccatc, tacataaaca, ttccattatc, 1500tgttgcaact, gaaaacaaaa, tctggaagtg, tggctgtgtt, tggtaaataa, cacagctatt, 1560atttttgacc, tcttcatagt, aaaatgaagt, aaaatggaaa, gtttggagta, ggagaaaaga, 1620gagattagat, cttaaggcac, ttgatggcct, ccaaaaatcc, tgactttgga, acatcaaatg, 1680catatgtgca, cttttatctt, tgttctgagt, cactgcagtc, cccaaagtca, tatgccaatg, 1740ttcacactga, aatactgtat, tgtacaccaa, actggaaggc, aattttccta, tgaaaatcaa, 1800agccggtata, ttcattggta, tgctctatac, agatatctta, ataaaaattt, tatagtgtga, 1860acagtgcaca, gagttaaggc, ataaaaatgt, atcattcttt, ataaaaatct, actgaaaatg, 1920tgtaatcatt, gaagacagtt, cttttaagca, tgattttaaa, atagcaactg, aaattcaatc, 1980attt, 1984＜210〉391＜211〉429＜212〉PRT＜213〉homo sapiens, (Homo, sapiens)＜400〉391Met, Arg, Val, Ser, Val, Pro, Gly, Pro, Ala, Ala, Ala, Ala, Ala, Pro, Ala, Ala

5??????????????????10??????????????????15Gly?Arg?Glu?Pro?Ser?Thr?Pro?Gly?Gly?Gly?Ser?Gly?Gly?Gly?Gly?Ala

20??????????????????25??????????????????30Val?Ala?Ala?Ala?Ser?Gly?Ala?Ala?Val?Pro?Gly?Ser?Val?Gln?Leu?Ala

35??????????????????40??????????????????45Leu?Ser?Val?Leu?His?Ala?Leu?Leu?Tyr?Ala?Ala?Leu?Phe?Ala?Phe?Ala

50??????????????????55??????????????????60Tyr?Leu?Gln?Leu?Trp?Arg?Leu?Leu?Leu?Tyr?Arg?Glu?Arg?Arg?Leu?Ser?65??????????????????70??????????????????75??????????????????80Tyr?Gln?Ser?Leu?Cys?Leu?Phe?Leu?Cys?Leu?Leu?Trp?Ala?Ala?Leu?Arg

85??????????????????90??????????????????95Thr?Thr?Leu?Phe?Ser?Ala?Ala?Phe?Ser?Leu?Ser?Gly?Ser?Leu?Pro?Leu

100?????????????????105?????????????????110Leu?Arg?Pro?Pro?Ala?His?Leu?His?Phe?Phe?Pro?His?Trp?Leu?Leu?Tyr

115?????????????????120?????????????????125Cys?Phe?Pro?Ser?Cys?Leu?Gln?Phe?Ser?Thr?Leu?Cys?Leu?Leu?Asn?Leu

130?????????????????135?????????????????140Tyr?Leu?Ala?Glu?Val?Ile?Cys?Lys?Val?Arg?Cys?Ala?Thr?Glu?Leu?Asp145?????????????????150?????????????????155?????????????????160Arg?His?Lys?Ile?Leu?Leu?His?Leu?Gly?Phe?Ile?Met?Ala?Ser?Leu?Leu

165?????????????????170?????????????????175Phe?Leu?Val?Val?Asn?Leu?Thr?Cys?Ala?Met?Leu?Val?His?Gly?Asp?Val

180?????????????????185?????????????????190Pro?Glu?Asn?Gln?Leu?Lys?Trp?Thr?Val?Phe?Val?Arg?Ala?Leu?Ile?Asn

195?????????????????200?????????????????205Asp?Ser?Leu?Phe?Ile?Leu?Cys?Ala?Ile?Ser?Leu?Val?Cys?Tyr?Ile?Cys

210?????????????????215?????????????????220Lys?Ile?Thr?Lys?Met?Ser?Ser?Ala?Asn?Val?Tyr?Leu?Glu?Ser?Lys?Gly225?????????????????230?????????????????235?????????????????240Met?Ser?Leu?Cys?Gln?Thr?Val?Ile?Val?Gly?Ser?Val?Val?Ile?Leu?Leu

245?????????????????250?????????????????255Tyr?Ser?Ser?Arg?Ala?Cys?Tyr?Asn?Leu?Val?Val?Val?Thr?Ile?Ser?Gln

260?????????????????265?????????????????270Asp?Thr?Leu?Glu?Ser?Pro?Phe?Asn?Tyr?Gly?Trp?Asp?Asn?Leu?Ser?Asp

275?????????????????280?????????????????285Lys?Ala?His?Val?Glu?Asp?Ile?Ser?Gly?Glu?Glu?Tyr?Ile?Val?Phe?Gly

290?????????????????295?????????????????300Met?Val?Leu?Phe?Leu?Trp?Glu?His?Val?Pro?Ala?Trp?Ser?Val?Val?Leu305?????????????????310?????????????????315?????????????????320Phe?Phe?Arg?Ala?Gln?Arg?Leu?Asn?Gln?Asn?Leu?Ala?Pro?Ala?Gly?Met

325?????????????????330?????????????????335Ile?Asn?Ser?His?Ser?Tyr?Ser?Ser?Arg?Ala?Tyr?Phe?Phe?Asp?Asn?Pro

340?????????????????345?????????????????350Arg?Arg?Tyr?Asp?Ser?Asp?Asp?Asp?Leu?Pro?Arg?Leu?Gly?Ser?Ser?Arg

355?????????????????360?????????????????365Glu?Gly?Ser?Leu?Pro?Asn?Ser?Gln?Ser?Leu?Gly?Trp?Tyr?Gly?Thr?Met

370?????????????????375?????????????????380Thr?Gly?Cys?Gly?Ser?Ser?Ser?Tyr?Thr?Val?Thr?Pro?His?Leu?Asn?Gly385?????????????????390?????????????????395?????????????????400Pro?Met?Thr?Asp?Thr?Ala?Pro?Leu?Leu?Phe?Thr?Cys?Ser?Asn?Leu?Asp

405?????????????????410?????????????????415Leu?Asn?Asn?His?His?Ser?Leu?Tyr?Val?Thr?Pro?Gln?Asn

420, 425＜210〉392＜211〉1584＜212〉DNA＜213〉homo sapiens, (Homo, sapiens)＜400〉392ggaagactgg, agcctttgcg, gcggcgctgc, ccctcccctg, gtccccgcga, gctcggaggg, 60cccggctggt, gctgcggggg, ccccgggagg, ttgaaaacta, agcatgggga, agagctgcaa, 120ggtggtcgtg, tgtggccagg, cgtctgtggg, caaaacttca, atcctggagc, agcttctgta, 180tgggaaccat, gtagtgggtt, cggagatgat, cgagacgcag, gaggacatct, acgtgggctc, 240cattgagaca, gaccgggggg, tgcgagagca, ggtgcgtttc, tatgacaccc, gggggctccg, 300agatggggcc, gaactgcccc, gacactgctt, ctcttgcact, gatggctacg, tcctggtcta, 360tagcacagat, agcagagagt, cttttcagcg, tgtggagctg, ctcaagaagg, agattgacaa, 420atccaaggac, aagaaggagg, tcaccatcgt, ggtccttggc, aacaagtgtg, acttacagga, 480gcagcggcgt, gtagacccag, atgtggctca, gcactgggcc, aagtcagaga, aggtgaagct, 540gtgggaggtg, tcagtggcgg, accggcgctc, cctcctggag, ccctttgtct, acttggccag, 600caagatgacg, caaccccaga, gcaagtctgc, cttccccctc, agccggaaga, acaagggcag, 660cggctccttg, gatggctgaa, gagctgccgt, tcctctttca, cgatcccagc, cccatttcag, 720tgtctggggc, tctggtagat, gtgttgaggg, caaagtagag, gacaagctgt, ctttcccagt, 780cagccaggga, gctccccgcc, aggccacgcc, ccagccactt, tgctccctct, cacctctggg, 840aagtgcaaat, actcttggtt, gacatcccct, tcctcagccc, tcccagccta, ctccccatcc, 900cagcttttag, aggatctgct, ccactgtctc, ctggggcagt, tgtgggtcac, tgtcccttcc, 960agctgcccca, gacaggaagc, agagtcacca, cgcagcagtg, tcccttcttg, ggtctgagtt, 1020cctattatag, gtaggggccc, caccctctgg, gcttcccatc, agcgacacac, acacacttat, 1080ggcaccagcc, tggactccag, aaaaagggtg, tccaggtatt, gtgtgtatgc, atttagttgt, 1140gcacacacaa, atatgctcct, atactggcat, taggcgtctc, ctcatccctc, accctgacct, 1200ttctcctgtc, cttttcttgg, ctggaagaag, ttggcctcct, gggagtgtag, ttttctgttt, 1260taaatccccc, acccctggct, gggctcagtg, gctcacccct, gtaatcccag, cactttggga, 1320ggccaaggcg, ggtcgattac, ttgaggtcag, gagttcacga, ccagcctggc, caacattgtg, 1380aaaccccatc, tctgccaaaa, atacaaaagt, tagccgggcg, tagtggcaca, tgcctgtaat, 1440cccagctacc, cggggaggct, gaggcaggag, aattgcttga, actcagaagg, cggaggctgc, 1500agtgagccga, gatcgtgcca, ctgcactcca, gcctggtcaa, cagagcaaga, ctccatctcg, 1560aaaaaaaaaa, aaaaaaaact, cgag, 1584＜210〉393＜211〉191＜212〉PRT＜213〉homo sapiens, (Homo, sapiens)＜400〉393Met, Gly, Lys, Ser, Cys, Lys, Val, Val, Val, Cys, Gly, Gln, Ala, Ser, Val, Gly

5??????????????????10??????????????????15Lys?Thr?Ser?Ile?Leu?Glu?Gln?Leu?Leu?Tyr?Gly?Asn?His?Val?Val?Gly

20??????????????????25??????????????????30Ser?Glu?Met?Ile?Glu?Thr?Gln?Glu?Asp?Ile?Tyr?Val?Gly?Ser?Ile?Glu

35??????????????????40??????????????????45Thr?Asp?Arg?Gly?Val?Arg?Glu?Gln?Val?Arg?Phe?Tyr?Asp?Thr?Arg?Gly

50??????????????????55??????????????????60Leu?Arg?Asp?Gly?Ala?Glu?Leu?Pro?Arg?His?Cys?Phe?Ser?Cys?Thr?Asp?65??????????????????70??????????????????75??????????????????80Gly?Tyr?Val?Leu?Val?Tyr?Ser?Thr?Asp?Ser?Arg?Glu?Ser?Phe?Gln?Arg

85??????????????????90??????????????????95Val?Glu?Leu?Leu?Lys?Lys?Glu?Ile?Asp?Lys?Ser?Lys?Asp?Lys?Lys?Glu

100?????????????????105?????????????????110Val?Thr?Ile?Val?Val?Leu?Gly?Asn?Lys?Cys?Asp?Leu?Gln?Glu?Gln?Arg

115?????????????????120?????????????????125Arg?Val?Asp?Pro?Asp?Val?Ala?Gln?His?Trp?Ala?Lys?Ser?Glu?Lys?Val

130?????????????????135?????????????????140Lys?Leu?Trp?Glu?Val?Ser?Val?Ala?Asp?Arg?Arg?Ser?Leu?Leu?Glu?Pro145?????????????????150?????????????????155?????????????????160Phe?Val?Tyr?Leu?Ala?Ser?Lys?Met?Thr?Gln?Pro?Gln?Ser?Lys?Ser?Ala

165?????????????????170?????????????????175Phe?Pro?Leu?Ser?Arg?Lys?Asn?Lys?Gly?Ser?Gly?Ser?Leu?Asp?Gly

180, 185, 190＜210〉394＜211〉1937＜212〉DNA＜213〉homo sapiens, (Homo, sapiens)＜400〉394ccggttcccc, cagctctggg, tacccggctc, tgcatcgcgt, cgccatgatg, ggccatcgtc, 60cagtgctcgt, gctcagccag, aacacaaagc, gtgaatccgg, aagaaaagtt, caatctggaa, 120acatcaatgc, tgccaagact, attgcagata, tcatccgaac, atgtttggga, cccaagtcca, 180tgatgaagat, gcttttggac, ccaatgggag, gcattgtgat, gaccaatgat, ggcaatgcca, 240ttcttcgaga, gattcaagtc, cagcatccag, cggccaagtc, catgatcgaa, attagccgga, 300cccaggatga, agaggttgga, gatgggacca, catcagtaat, tattcttgca, ggggaaatgc, 360tgtctgtagc, tgagcacttc, ctggagcagc, agatgcaccc, aacagtggtg, atcagtgctt, 420accgcaaggc, attggatgat, atgatcagca, ccctaaagaa, aataagtatc, ccagtcgaca, 480tcagtgacag, tgatatgatg, ctgaacatca, tcaacagctc, tattactacc, aaagccatca, 540gtcggtggtc, atctttggct, tgcaacattg, ccctggatgc, tgtcaagatg, gtacagtttg, 600aggagaatgg, tcggaaagag, attgacataa, aaaaatatgc, aagagtggaa, aagatacctg, 660gaggcatcat, tgaagactcc, tgtgtcttgc, gtggagtcat, gattaacaag, gatgtgaccc, 720atccacgtat, gcggcgctat, atcaagaacc, ctcgcattgt, gctgctggat, tcttctctgg, 780aatacaagaa, aggagaaagc, cagactgaca, ttgagattac, acgagaggag, gacttcaccc, 840gaattctcca, gatggaggaa, gagtacatcc, agcagctctg, tgaggacatt, atccaactga, 900agcccgatgt, ggtcatcact, gaaaagggca, tctcagattt, agctcagcac, taccttatgc, 960gggccaatat, cacagccatc, cgcagagtcc, ggaagacaga, caataatcgc, attgctagag, 1020cctgtggggc, ccggatagtc, agccgaccag, aggaactgag, agaagatgat, gttggaacag, 1080gagcaggcct, gttggaaatc, aagaaaattg, gagatgaata, ctttactttc, atcactgact, 1140gcaaagaccc, caaggcctgc, accattctcc, tccggggggc, tagcaaagag, attctctcgg, 1200aagtagaacg, caacctccag, gatgccatgc, aagtgtgtcg, caatgttctc, ctggaccctc, 1260agctggtgcc, agggggtggg, gcctccgaga, tggctgtggc, ccatgccttg, acagaaaaat, 1320ccaaggccat, gactggtgtg, gaacaatggc, catacagggc, tgttgcccag, gccctagagg, 1380tcattcctcg, taccctgatc, cagaactgtg, gggccagcac, catccgtcta, cttacctccc, 1440ttcgggccaa, gcacacccag, gagaactgtg, agacctgggg, tgtaaatggt, gagacgggta, 1500ctttggtgga, catgaaggaa, ctgggcatat, gggagccatt, ggctgtgaag, ctgcagactt, 1560ataagacagc, agtggagacg, gcagttctgc, tactgcgaat, tgatgacatc, gtttcaggcc, 1620acaaaaagaa, aggcgatgac, cagagccggc, aaggcggggc, tcctgatgct, ggccaggagt, 1680gagtgctagg, caaggctact, tcaatgcaca, gaaccagcag, agtctcccct, tttcctgagc, 1740cagagtgcca, ggaacactgt, ggacgtcttt, gttcagaagg, gatcaggttg, gggggcagcc, 1800cccagtccct, ttctgtccca, gctcagtttt, ccaaaagaca, ctgacatgta, attcttctct, 1860attgtaaggt, ttccatttag, tttgcttccg, atgattaaat, ctaagtcatt, tgaaaaaaaa, 1920aaaaaaaaaa, actcgag, 1937＜210〉395＜211〉1675＜212〉DNA＜213〉homo sapiens, (Homo, sapiens)＜400〉395gcgcgaatcg, cggtcgcgag, ccatggagga, ggaggcatcg, tccccggggc, tgggctgcag, 60caagccgcac, ctggagaagc, tgaccctggg, catcacgcgc, atcctagaat, cttccccagg, 120tgtgactgag, gtgaccatca, tagaaaagcc, tcctgctgaa, cgtcatatga, tttcttcctg, 180ggaacaaaag, aataactgtg, tgatgcctga, agatgtgaag, aacttttacc, tgatgaccaa, 240tggcttccac, atgacatgga, gtgtgaagct, ggatgagcac, atcattccac, tgggaagcat, 300ggcaattaac, agcatctcaa, aactgactca, gctcacccag, tcttccatgt, attcacttcc, 360taatgcaccc, actctggcag, acctggagga, cgatacacat, gaagccagtg, atgatcagcc, 420agagaagcct, cactttgact, ctcgcagtgt, gatatttgag, ctggattcat, gcaatggcag, 480ttggaaagtt, tgccttgtct, acaaaagtgg, gaaaccagca, ttagcagaag, acactgagat, 540ctggttcctg, gacagagcgt, tatactggca, ttttctcaca, gacaccttta, ctgcctatta, 600ccgcctgctc, atcacccacc, tgggcctgcc, ccagtggcaa, tatgccttca, ccagctatgg, 660cattagccca, caggccaagc, aatggttcag, catgtataaa, cctatcacct, acaacacaaa, 720cctgctcaca, gaagagaccg, actcctttgt, gaataagcta, gatcccagca, aagtgtttaa, 780gagcaagaac, aagatcgtaa, tcccaaaaaa, gaaagggcct, gtgcagcctg, caggtggcca, 840gaaagggccc, tcaggaccct, ccggtccctc, cacttcctcc, acttctaaat, cctcctctgg, 900ctctggaaac, cccacccgga, agtgagcacc, cctccctcca, actccctacc, agctccagag, 960tggtggtttc, catgcacaga, tggccctagg, ggtgacctcc, agttttgcgt, gtggaccgta, 1020ggcctctttc, tagttgaatg, accaaaattg, taaggctttt, agtcccaccg, acattagcca, 1080ggctcgtagt, gaggcctcca, gagcaggttg, tgctgtcccc, tgcctctgga, agcaatgggg, 1140aatttggaat, cttgtgtaag, tgcccaaata, agtctgagtg, ctttcctctt, cttcaacact, 1200caaccctcaa, tcccttagca, ctgattgatt, agagaggtcc, cccaaagaaa, ccactggttt, 1260tgacccatga, agcattagaa, ctgcattgtt, cattcaggag, ccactagtca, catatgacta, 1320tttaaattta, aagtaaattg, tatgaaaaat, tcatttcttc, aattgcatta, gccacatttt, 1380gagtattcat, gtggctggta, gattctgtat, tagcacaaag, atatggaaca, tttccatcac, 1440cacagaaagt, tctgttggac, agcactgcat, tagaatattt, tcatactgct, cttcctcaat, 1500taatttttgt, tgttaatgtt, gatgtcttca, ttggatgggt, cataatgttc, catgaaacct, 1560ctcaagtaca, caattgtatg, ttctttgtat, cccttaccac, aaatatctcg, ctctgctcat, 1620ttcttttgca, gcttcctata, aagtttgtct, tcctcatcaa, aaaaaaaaaa, aaaaa, 1675＜210〉396＜211〉559＜212〉PRT＜213〉homo sapiens, (Homo, sapiens)＜400〉396Gly, Ser, Pro, Ser, Ser, Gly, Tyr, Pro, Ala, Leu, His, Arg, Val, Ala, Met, Met

5??????????????????10??????????????????15Gly?His?Arg?Pro?Val?Leu?Val?Leu?Ser?Gln?Asn?Thr?Lys?Arg?Glu?Ser

20??????????????????25??????????????????30Gly?Arg?Lys?Val?Gln?Ser?Gly?Asn?Ile?Asn?Ala?Ala?Lys?Thr?Ile?Ala

35??????????????????40??????????????????45Asp?Ile?Ile?Arg?Thr?Cys?Leu?Gly?Pro?Lys?Ser?Met?Met?Lys?Met?Leu

50??????????????????55??????????????????60Leu?Asp?Pro?Met?Gly?Gly?Ile?Val?Met?Thr?Asn?Asp?Gly?Asn?Ala?Ile?65??????????????????70??????????????????75??????????????????80Leu?Arg?Glu?Ile?Gln?Val?Gln?His?Pro?Ala?Ala?Lys?Ser?Met?Ile?Glu

85??????????????????90??????????????????95Ile?Ser?Arg?Thr?Gln?Asp?Glu?Glu?Val?Gly?Asp?Gly?Thr?Thr?Ser?Val

100?????????????????105?????????????????110Ile?Ile?Leu?Ala?Gly?Glu?Met?Leu?Ser?Val?Ala?Glu?His?Phe?Leu?Glu

115?????????????????120?????????????????125Gln?Gln?Met?His?Pro?Thr?Val?Val?Ile?Ser?Ala?Tyr?Arg?Lys?Ala?Leu

130?????????????????135?????????????????140Asp?Asp?Met?Ile?Ser?Thr?Leu?Lys?Lys?Ile?Ser?Ile?Pro?Val?Asp?Ile145?????????????????150?????????????????155?????????????????160Ser?Asp?Ser?Asp?Met?Met?Leu?Asn?Ile?Ile?Asn?Ser?Ser?Ile?Thr?Thr

165?????????????????170?????????????????175Lys?Ala?Ile?Ser?Arg?Trp?Ser?Ser?Leu?Ala?Cys?Asn?Ile?Ala?Leu?Asp

180?????????????????185?????????????????190Ala?Val?Lys?Met?Val?Gln?Phe?Glu?Glu?Asn?Gly?Arg?Lys?Glu?Ile?Asp

195?????????????????200?????????????????205Ile?Lys?Lys?Tyr?Ala?Arg?Val?Glu?Lys?Ile?Pro?Gly?Gly?Ile?Ile?Glu

210?????????????????215?????????????????220Asp?Ser?Cys?Val?Leu?Arg?Gly?Val?Met?Ile?Asn?Lys?Asp?Val?Thr?His225?????????????????230?????????????????235?????????????????240Pro?Arg?Met?Arg?Arg?Tyr?Ile?Lys?Asn?Pro?Arg?Ile?Val?Leu?Leu?Asp

245?????????????????250?????????????????255Ser?Ser?Leu?Glu?Tyr?Lys?Lys?Gly?Glu?Ser?Gln?Thr?Asp?Ile?Glu?Ile

260?????????????????265?????????????????270Thr?Arg?Glu?Glu?Asp?Phe?Thr?Arg?Ile?Leu?Gln?Met?Glu?Glu?Glu?Tyr

275?????????????????280?????????????????285Ile?Gln?Gln?Leu?Cys?Glu?Asp?Ile?Ile?Gln?Leu?Lys?Pro?Asp?Val?Val

290?????????????????295?????????????????300Ile?Thr?Glu?Lys?Gly?Ile?Ser?Asp?Leu?Ala?Gln?His?Tyr?Leu?Met?Arg305?????????????????310?????????????????315?????????????????320Ala?Asn?Ile?Thr?Ala?Ile?Arg?Arg?Val?Arg?Lys?Thr?Asp?Asn?Asn?Arg

325?????????????????330?????????????????335Ile?Ala?Arg?Ala?Cys?Gly?Ala?Arg?Ile?Val?Ser?Arg?Pro?Glu?Glu?Leu

340?????????????????345?????????????????350Arg?Glu?Asp?Asp?Val?Gly?Thr?Gly?Ala?Gly?Leu?Leu?Glu?Ile?Lys?Lys

355?????????????????360?????????????????365Ile?Gly?Asp?Glu?Tyr?Phe?Thr?Phe?Ile?Thr?Asp?Cys?Lys?Asp?Pro?Lys

370?????????????????375?????????????????380Ala?Cys?Thr?Ile?Leu?Leu?Arg?Gly?Ala?Ser?Lys?Glu?Ile?Leu?Ser?Glu385?????????????????390?????????????????395?????????????????400Val?Glu?Arg?Asn?Leu?Gln?Asp?Ala?Met?Gln?Val?Cys?Arg?Asn?ValLeu

405?????????????????410?????????????????415Leu?Asp?Pro?Gln?Leu?Val?Pro?Gly?Gly?Gly?Ala?Ser?Glu?Met?Ala?Val

420?????????????????425?????????????????430Ala?His?Ala?Leu?Thr?Glu?Lys?Ser?Lys?Ala?Met?Thr?Gly?Val?Glu?Gln

435?????????????????440?????????????????445Trp?Pro?Tyr?Arg?Ala?Val?Ala?Gln?Ala?Leu?Glu?Val?Ile?Pro?Arg?Thr

450?????????????????455?????????????????460Leu?Ile?Gln?Asn?Cys?Gly?Ala?Ser?Thr?Ile?Arg?Leu?Leu?Thr?Ser?Leu465?????????????????470?????????????????475?????????????????480Arg?Ala?Lys?His?Thr?Gln?Glu?Asn?Cys?Glu?Thr?Trp?Gly?Val?Asn?Gly

485?????????????????490?????????????????495Glu?Thr?Gly?Thr?Leu?Val?Asp?Met?Lys?Glu?Leu?Gly?Ile?Trp?Glu?Pro

500?????????????????505?????????????????510Leu?Ala?Val?Lys?Leu?Gln?Thr?Tyr?Lys?Thr?Ala?Val?Glu?Thr?Ala?Val

515?????????????????520?????????????????525Leu?Leu?Leu?Arg?Ile?Asp?Asp?Ile?Val?Ser?Gly?His?Lys?Lys?Lys?Gly

530 535 540Asp Asp Gln Ser Arg Gln Gly Gly Ala Pro Asp Ala Gly Gln Glu545,550 555＜210〉397＜211〉307＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉397Arg Glu Ser Arg Ser Arg Ala Met Glu Glu Glu Ala Ser Ser Pro Gly

5??????????????????10??????????????????15Leu?Gly?Cys?Ser?Lys?Pro?His?Leu?Glu?Lys?Leu?Thr?Leu?Gly?Ile?Thr

20??????????????????25??????????????????30Arg?Ile?Leu?Glu?Ser?Ser?Pro?Gly?Val?Thr?Glu?Val?Thr?Ile?Ile?Glu

35??????????????????40??????????????????45Lys?Pro?Pro?Ala?Glu?Arg?His?Met?Ile?Ser?Ser?Trp?Glu?Gln?Lys?Asn

50??????????????????55??????????????????60Asn?cys?Val?Met?Pro?Glu?Asp?Val?Lys?Asn?Phe?Tyr?Leu?Met?Thr?Asn65???????????????????70??????????????????75??????????????????80Gly?Phe?His?Met?Thr?Trp?Ser?Val?Lys?Leu?Asp?Glu?His?Ile?Ile?Pro

85??????????????????90??????????????????95Leu?Gly?Ser?Met?Ala?Ile?Asn?Ser?Ile?Ser?Lys?Leu?Thr?Gln?Leu?Thr

100?????????????????105?????????????????110Gln?Ser?Ser?Met?Tyr?Ser?Leu?Pro?Asn?Ala?Pro?Thr?Leu?Ala?Asp?Leu

115?????????????????120?????????????????125Glu?Asp?Asp?Thr?His?Glu?Ala?Ser?Asp?Asp?Gln?Pro?Glu?Lys?Pro?His

130?????????????????135?????????????????140Phe?Asp?Ser?Arg?Ser?Val?Ile?Phe?Glu?Leu?Asp?Ser?Cys?Asn?Gly?Ser140?????????????????150?????????????????155?????????????????160Gly?Lys?Val?Cys?Leu?Val?Tyr?Lys?Ser?Gly?Lys?Pro?Ala?Leu?Ala?Glu

165?????????????????170?????????????????175Asp?Thr?Glu?Ile?Trp?Phe?Leu?Asp?Arg?Ala?Leu?Tyr?Trp?His?Phe?Leu

180?????????????????185?????????????????190Thr?Asp?Thr?Phe?Thr?Ala?Tyr?Tyr?Arg?Leu?Leu?Ile?Thr?His?Leu?Gly

195?????????????????200?????????????????205Leu?Pro?Gln?Trp?Gln?Tyr?Ala?Phe?Thr?ser?Tyr?Gly?Ile?Ser?Pro?Gln

210?????????????????215?????????????????220Ala?Lys?Gln?Trp?Phe?Ser?Met?Tyr?Lys?Pro?Ile?Thr?TVr?Asn?Thr?Asn225?????????????????230?????????????????235?????????????????240Leu?Leu?Thr?Glu?Glu?Thr?Asp?Ser?Phe?Val?Asn?Lys?Leu?Asp?Pro?Ser

245?????????????????250?????????????????255Lys?Val?Phe?Lys?Ser?Lys?Asn?Lys?Ile?Val?Ile?Pro?Lys?Lys?Lys?Gly

260?????????????????265?????????????????270Pro?Val?Gln?Pro?Ala?Gly?Gly?Gln?Lys?Gly?Pro?Ser?Gly?Pro?Ser?Gly

275?????????????????280?????????????????285Pro?Ser?Thr?Ser?Ser?Thr?Ser?Lys?Ser?Ser?Ser?Gly?Ser?Gly?Asn?Pro

290295300 Thr Arg Lys 305 <210> 398 <211> 416 <212> DNA <213> Homo (Homo sapiens) <400> 398 agaattcggc acgaggattg cctatctcca gtgcaacaac catcaagtgt gctgaaagtc 60 ttcagccggt tgctgcagca gtggaagaaa gggctacagg tccagtcttg ataagcaccg 120 ccgactttga ggggcctatg cccagtgcgc ccccagaagc tgaaagtcct cttgcctcaa 180 ccagcaagga ggagaaggat gaatgtgctc tcatttccac tagcatagca gaagaatgtg 240 aggcttctgt ttccggtgta gttgttgaaa gtgaaaatga gcgagctggc acagtcatgg 300 aagaaaaaga cgggagtggc atcatctcta cgagctcggt ggaagactgt gagggcccag 360 tgtccagtgc tgtccctcaa gaggaaggcg acccctcagt cacaccagcg gaagag 416 <210> 399 <211> 259 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (259) <223> n = A, T, C or G <400> 399 caaagaattc ggcacgaggg ggcgacctgc attcggacgt caccgaggcc atgctgtacg 60 aaaagttcag ccccgcgggg cctgtgctgt ncatccgggt ctgccgngat atgatcaccc 120 gccgctccct gggctatgcc tacgncaact tccancaacc ggccgacgct gatcgggctt 180 tggacaccat gaactttgat gtgattnagg gaaanccaat ccttatcntg tnnnaatcat 240 aggnatcctt ctttgacaa 259 <210> 400 <211> 410 <212> DNA <213> Homo (Homo sapiens) <400> 400 ggcacgaggg gagagcggac cccagagagc cctgagcagc cccaccgccg ccgccggcct 60 agttaccatc acaccccggg aggagccgca gctgccgcag ccggccccag tcaccatcac 120 cgcaaccatg agcagcgagg ccgagaccca gcagccgccc gccgcccccc cccgccgccc 180 ccgccctcag cgccgccgac accaagcccg gcactacggg cagcggcgca gggagcggtg 240 gcccgggcgg cctcacatcg gcggcgcctg ccggcgggga caagaaggtc atcgcaacga 300 aggttttggg aacagtaaaa tggttcaatg taaggaacgg atatggtttc atcaacagga 360 atgacaccaa ggaagatgta tttgtacacc agactgccat aaagaagaat 410 <210> 401 <211> 433 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (433) <223> n = A, T, C or G <400> 401 ggnacgagga atcatggcgg ctgcgctgtt cgtgctgctg ggattcgcgc tgctgggcac 60 ccacggagcc tccggggctg ccggcacagt cttcactacc gtagaagacc ttggctccaa 120 gatactcctc acctgctcct tgaatgacag cgccacagag gtcacagggc accgctggct 180 gaaggggggc gtggtgctga aggaggacgc gctgcccggc cagaaaacgg agttcaaggt 240 ggactccgac gaccagtggg gagagtactc ctgcgtcttc ctccccgagc ccatgggcac 300 ggccaacatc cagctccacg ggcctcccag agtgaaggcc gtgaagtcgt cagaacacat 360 caacgagggg gagacggcca tgctggtctg caagtcagag tccgtgccac ctgtcactga 420 ctgggcctgg tac 433 <210> 402 <211> 434 <212> DNA <213> Homo (Homo sapiens) <400> 402 ggcacgaggc tcggactgag caggactttc cttatcccag ttgattgtgc agaatacact 60 gcctgtcgct tgtcttctat tcaccatggc ttcttctgat atccaggtga aagaactgga 120 gaagcgtgcc tcaggccagg cttttgagct gattctcagc cctcggtcaa aaggatctgt 180 tccagaattc cccctttccc ctccaaagaa gaaggatctt tccctggagg aaattcagaa 240 gaaattagaa gctgcagaag aaagacgcaa gtcccatgaa gctgaggtct tgaagcagct 300 ggctgagaaa cgagagcacg agaaagaagt gcttcagaag gcaatagaag agaacaacaa 360 cttcagtaaa atggcagaag agaaactgac ccacaaaatg gaagctaata aagagaaccg 420 agaggcacaa atgg 434 <210> 403 <211> 435 <212> DNA <213> Homo (Homo sapiens) <400> 403 ggcacgagga actgctgttg ccattcaaac cattgaggag catcctgcat cttttgactg 60 gagctctttt aagccaatgg gatttgaagt atcatttctg aagtttcttg aggagtctgc 120 agtgaagcag aagaaaaata ctgacaaaga ccatccgaat actggaaaca aaaaaggatc 180 ccattcaaat tcaagaaaaa atattgataa gactgctgtg actagtggaa atcatgtatg 240 tccttgtaaa gaaagcgaaa cgtttgtaca gtttgccaat ccatcacagc ttcagtgcag 300 tgataatgta aaaattgttt tagacaagaa tcttaaagat tgcactgagc ttgtcttaaa 360 gcaacttcag gaaatgaaac ctaccgtcag tctgaaaaaa cttgaagtac attcaaatga 420 tccagatatg tctgt 435 <210> 404 <211> 416 <212> DNA <213> Homo (Homo sapiens) <400> 404 aaagaattcg gcacgaggcg ccgctccgcc acgaccaccg ccgcctcctg ccctgcagcc 60 accgccaccg cctgtgtcgc cgccgcctcg ggaccggctg tatgattagg ccacaatctt 120 caatgagtaa acatattcct caattctgtg gtgttcttgg tcacacattt atggagtttc 180 tgaagggcag tggagattac tgccaggcac agcacgacct ctatgcagac aagtgaactg 240 tagaaactga ttactgctcc accaagaagc ccccataaga gtggttatcc tggacacaga 300 agtgttgaat tgaaatccac agagcatttt acaagagttc tgacctggat ggggtaaacc 360 tcagtgcact tcttttctgt tggcctcagt attactggat tgaagaattg ctgctt 416 <210> 405 <211> 435 <212> DNA <213> Homo (Homo sapiens) <400> 405 ggcacgaggg ctgccggagg gtcgttttaa agggcccgcg cgttgccgcc ccctcggccc 60 gccatgctgc tatccgtgcc gctgctgctc ggcctcctcg gcctggccgt cgccgagcct 120 gccgtctact tcaaggagca gtttctggac ggagacgggt ggacttcccg ctggatcgaa 180 tccaaacaca agtcagattt tggcaaattc gttctcagtt ccggcaagtt ctacggtgac 240 gaggagaaag ataaaggttt gcagacaagc caggatgcac gcttttatgc tctgtcggcc 300 agtttcgagc ctttcagcaa caaaggccag acgctggtgg tgcagttcac ggtgaaacat 360 gagcagaaca tcgactgtgg gggcggctat gtgaagctgt ttcctaatag tttggaccag 420 acagacatgc acgga 435 <210> 406 <211> 424 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (424) <223> n = A, T, C or G <400> 406 gcccaaaccc actccacctt actaccagac aaccttagcc aaaccattta cccaaataaa 60 gtataggcga tagaaattga aacctggcgc aatagatata gtaccgcaag ggaaagatga 120 aaaattataa ccaagcataa tatagcaagg actaacccct ataccttctg cataatgaat 180 taactagaaa taactttgca aggagagcca aagctaagac ccccgaaacc agacgagcta 240 cctaagaaca gctaaaagag cacacccgtc tatgtagcaa aatagtggga agatttatag 300 gtagaggcga caaacctacc gagcctggtg atagctggtt gtccaagata gaatcttagt 360 tcaactttaa atttgcccac agaaccctct aaatcccctt gnaaatttaa ctgntagtcc 420 aaag 424 <210> 407 <211> 423 <212> DNA <213> Homo (Homo sapiens) <400> 407 gctcctaccg gcgcacgtgg tgccgccgct gctgcctccc gctcgccctg aacccagtgc 60 ctgcagccat ggctcccggc cagctcgcct tatttagtgt ctctgacaaa accggccttg 120 tggaatttgc aagaaacctg accgctcttg gtttgaatct ggtcgcttcc ggagggactg 180 caaaagctct cagggatgct ggtctggcag tcagagatgt ctctgagttg acgggatttc 240 ctgaaatgtt ggggggacgt gtgaaaactt tgcatcctgc agtccatgct ggaatcctag 300 ctcgtaatat tccagaagat aatgctgaca tggccagact tgatttcaat cttataagag 360 ttgttgcctg caatctctat ccctttgtaa agacagtggc ttctccaggt gtaagtgttg 420 agg 423 <210> 408 <211> 424 <212> DNA <213> Homo (Homo sapiens) <400> 408 gaaaaaaaat agcttactga attctataag atgtgtggga atctcaccta tcaaaaatag 60 gtaaaaagag cctccaaacc tgctttgatt ttattcacct attcttttag gccaggaact 120 aatttacctc tcactatcct gttccctctt gctatcttgt ggagtctcta aagacaaagg 180 tataaagagc ttttggtagg tgaattaata atcaactaga tggcatttcc aaatgggatt 240 gcacatactg tggggcaagt cccaagtgaa cttcaaagtg agacgtttat ttgagtaatc 300 cttccagatt aacaataatc ataatagcag ttaccacttc ctgagtactt tctatatgcc 360 atgtattgag cttgctcact tctttatgtg gattcttatt taatcttaat accaagatga 420 ggtg 424 <210> 409 <211> 398 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (398) <223> n = A, T, C or G <400> 409 gctcgactct tagcttgtcg gggacggtaa ccgggacccg gtgtctgctc ctgtcgcctt 60 cgcctcctaa tccctagcca ctatgcgtga gtgcatctcc atccacgttg gccaggctgg 120 tgtccagatt ggcaatgcct gctgggagct ctactgcctg gaacacggca tccagcccga 180 tggccagatg ccaagtgaca agaccattgg gggaggagat gactccttca acaccttctt 240 cagtgagacg ggcgctggca agcacgtgcc ccgggctgng tttgtagact tggaacccac 300 agtnattgat gaagntcgna ctggcaccta cccgcaggtc ttncaccctg ancanntcat 360 nacaggcaag gaagatgctg ncaaataact atgcccga 398 <210> 410 <211> 423 <212> DNA <213> Homo (Homo sapiens) <400> 410 gccccacccc acctgcccgc tgcggctctc cgcgggagat ctcaccgttc tggagacagg 60 gctcgctcgc tctcacgctg cccggccagc ccgcttctct gcccggagcc atgaatctca 120 gtagcgccag tagcacggag gaaaaggcag tgacgaccgt gctctggggc tgcgagctca 180 gtcaggagag gcggacttgg accttcagac cccagctgga ggggaagcag agctgcaggc 240 tgttgcttca tacgatttgc ttgggggaga aagccaaaga ggagatgcat cgcgtggaga 300 tcctgccccc agcaaaccag gaggacaaga agatgcagcc ggtcaccatt gcctcactcc 360 aggcctcagt cctccccatg gtctccatgg taggagtgca gctttctccc ccagttactt 420 tcc 423 <210> 411 <211> 424 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (424) <223> n = A, T, C or G <400> 411 gcggaggcga ctagcggcgg cgggagcggc gccgagaggc cgtgcgggac gcgggcgcca 60 ggaccggccg aacgcagagg ttgattcttc accacactga aaccattagg aaaaatcctt 120 gtggttaaca gcagaggctt cagagtgtaa cctgtactcg ggcctagaaa ttatttaaaa 180 tggcgactga tacgtctcaa ggtgaactcg tccatcctaa ggcactccca cttatagtag 240 gagctcagct gatccacgcg gacaagttag gtgagaaggt agaagatagc accatgccga 300 ttcgtcgaac tgtgaattct acccgggaaa ctcctcccaa aagcaagctt gctgaagggg 360 aggaagaaan gccagaacca gacataagtt cagaggaatc tgtctccact gtagaagaac 420 aaga 424 <210> 412 <211> 430 <212> DNA <213> Homo (Homo sapiens) <400> 412 ggcacgaggg gaagccggcg ccagttcgcg gggctccggg ccgccactca gagctatgag 60 ctacggccgc ccccctcccg atgtggaggg tatgacctcc ctcaaggtgg acaacctgac 120 ctaccgcacc tcgcccgaca cgctgaggcg cgtcttcgag aagtacgggc gcgtcggcga 180 cgtgtacatc ccgcgggatc gctacaccaa ggagtcccgc ggcttcgcct tcgttcgctt 240 tcacgacaag cgcgacgctg aggacgctat ggatgccatg gacggggccg tgctggacgg 300 ccgcgagctg cgggtgcaaa tggcgcgcta cggccgcccc ccggactcac accacagccg 360 ccggggaccg ccaccccgca ggtacggggg cggtggctac ggacgccgga gccgcagccc 420 taggcggcgt 430 <210> 413 <211> 429 <212> DNA <213> Homo (Homo sapiens) <400> 413 ggcacgaggt cggcccggcc atcttgtggg aagagctgaa gcaggcgctc ttggctcggc 60 gcggcccgct gcaatccgtg gaggaacgcg ccgccgagcc accatcatgc ctgggcactt 120 acaggaaggc ttcggctgcg tggtcaccaa ccgattcgac cagttatttg acgacgaatc 180 ggaccccttc gaggtgctga aggcagcaga gaacaagaaa aaagaagccg gcgggggcgg 240 cgttgggggc cctggggcca agagcgcagc tcaggccgcg gcccagacca actccaacgc 300 ggcaggcaaa cagctgcgca aggagtccca gaaagaccgc aagaacccgc tgccccccag 360 cgttggcgtg gttgacaaga aagaggagac gcagccgccc gtggcgctta agaaagaagg 420 aataagacg 429 <210> 414 <211> 429 <212> DNA <213> Homo (Homo sapiens) <400> 414 ggcacgagga cgggcccggc tgccggcccc cgctctgccc tgcataataa aatggctaat 60 caggtgaatg gtaatgcggt acagttaaaa gaagaggaag aaccaatgga tacttccagt 120 gtaactcaca cagaacacta caagacactg atagaggcag gcctcccaca gaaggtggca 180 gaaagacttg atgaaatatt tcagacagga ttggtagctt atgtcgatct tgatgaaaga 240 gcaattgatg ctctcaggga atttaatgaa gaaggagctc tgtctgtact acagcagttc 300 aaggaaagtg acttatcaca tgttcagaac aaaagtgcat ttttatgtgg agttatgaag 360 acctacaggc agagagagaa acaggggagc aaggtgcaag agtccacaaa gggacctgat 420 gaagcgaag 429 <210> 415 <211> 398 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (398) <223> n = A, T, C or G <400> 415 gcggtcgtaa gggctgagga tttttggtcc gcacgctcct gctcctgact caccgctgtt 60 cgctctcgcc gaggaacaag tcggtcagga agcccgcgcg caacagccat ggcttttaag 120 gataccggaa aaacacccgt ggagccggag gtggcaattc accgaattcg aatcacccta 180 acaagccgca acgtaaaatc cttggaaaag gtgtgtgctg acttgataag aggcgcaaaa 240 gaaaagaatc tcaaagtact ttgagaatca ctacaagaaa aactccttgt ggtgaaggtt 300 ctaagacgtg ggatcgtttc cagatgagaa ttcacaagcg actcattgac ttgcacagtc 360 cttctgagat tgttaagcan attacttcca tcantatt 398 <210> 416 <211> 269 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (269) <223> n = A, T, C or G <400> 416 gccgaggcag gaagctgtga gtgcgcggtt gcggggtcgc attgtggcta cggctttgcg 60 tccccggcgg gcagccccag gctggtcccc gcctccgctc tccccaccgg cggggaaagc 120 agctggtgtg ggaggaaagg ctccatcccc cgccccctct ctcccgctgt tggctggcan 180 gatcttttgg cagtcctgtg cnctcnctcc ccgnccggat cctnctgacc ctganattcn 240 nggtntnacn nnccgtncac gccttgntt 269 <210> 417 <211> 408 <212> DNA <213> Homo (Homo sapiens) <400> 417 ggccgggaga accgttcgcg gaggaaaggc gaactagtgt tgggatggcc accaactggg 60 ggagcctctt gcaggataaa cagcagctag aggagctggc acggcaggcc gtggaccggg 120 ccctggctga gggagtattg ctgaggacct cacaggagcc cacttcctcg gaggtggtga 180 gctatgcccc attcacgctc ttcccctcac tggtccccag tgccctgctg gagcaagcct 240 atgctgtgca gatggacttc aacctgctag tggatgctgt cagccagaac gctgccttcc 300 tggagcaaac tctttccagc accatcaaac aggatgactt taccgctcgt ctctttgaca 360 tccacaagca agtcctaaaa gagggcattg cccagactgt gttcctgg 408 <210> 418 <211> 402 <212> DNA <213> Homo (Homo sapiens) <400> 418 gagccgggca gccgcttccc gcccccgagc aggagccggt gcgagcggag cagagccgag 60 gtcgggccgc gagcggagcc ggctgagcgg gcgccgagct cccgccatgg cccggaacac 120 gctgtcctcg cgcttccgcc gggtggacat cgacgaattt gacgagaaca aatttgtgga 180 cgagcaggag gaggcggcgg cggcggcggc ggagccaggc ccggacccga gcgaggtgga 240 cgggctcctg cggcaagggg acatgcttcg ggcattccat gcagccttgc ggaactctcc 300 cgtcaacacc aagaatcaag ctgtgaagga gcgagcccag ggcgtggtgc tgaaagtgct 360 cacaaacttc aagagcagtg agattgagca ggctgtgcag tc 402 <210> 419 <211> 406 <212> DNA <213> Homo (Homo sapiens) <400> 419 gcccgggcta gcggcctggg ttgggctttg tagctgctcc gcaggcccag cccgggccgc 60 gctcgcagag tcctaggcgg tgcgcggcct cctgcctcct ccctcctcgg cggtcgcggc 120 ccgccggcct ccgcggtgcc tgccttcgct ctcaggttga ggagctcaag cttgggaaaa 180 tggtgtgcat tccttgtatc gtcattccag ttctgctctg gatctacaaa aaattcctgg 240 agccatatat ataccctctg gtttccccct tcgttaagtc gtatatggcc taaaaaaaga 300 attcaaagaa atccaatgat ccaaacaaaa gggcaaaagt aaaaactttt aaaggggtgc 360 aagaacattg aaatgggaat tacccaacca aaaaagggaa cccaac 406 <210> 420 <211> 371 <212> DNA <213> Homo (Homo sapiens) <400> 420 cagccatcgt ggtgtgttct tgactccgct gctcgccatg tcttctcaca agactttcag 60 gattaagcga ttcctggcca agaaacaaaa gcaaaatcgt cccattcccc agtggattcg 120 gatgaaaact ggaaataaaa tcaggtacaa ctccaaaagg agacattgga gaagaaccaa 180 gctgggtcta taaggaattg cacatgagat ggcacacata tttatgctgt ctgaaggtca 240 cgatcatgtt accatatcaa gctgaaaatg tcaccactat ctggagattt cgacgtgttt 300 tcctctctga atctgttatg aacacgttgg ttggctggat tcagtaataa atatgtaagg 360 cctttctttt t 371 <210> 421 <211> 51 <212> PRT <213> Homo (Homo sapiens) <400> 421 Met Ser Ser His Lys Thr Phe Arg Ile Lys Arg Phe Leu Ala Lys Lys ...

5??????????????????10??????????????????15Gln?Lys?Gln?Asn?Arg?Pro?Ile?Pro?Gln?Trp?Ile?Arg?Met?Lys?Thr?Gly

20??????????????????25??????????????????30Asn?Lys?Ile?Arg?Tyr?Asn?Ser?Lys?Arg?Arg?His?Trp?Arg?Arg?Thr?Lys

35??????????????????40??????????????????45Leu?Gly?Leu

50 <210> 422 <211> 12308 <212> DNA <213> Homo (Homo sapiens) <400> 422 ttgttttcta gcagtgacaa gttcactttg aatcaggata tgtgtgtagt ttgtggcagt 60 tttggccaag gagcagaagg aagattactt gcctgttctc agtgtggtca gtgttaccat 120 ccatactgtg tcagtattaa gatcactaaa gtggttctta gcaaaggttg gaggtgtctt 180 gagtgcactg tgtgtgaggc ctgtgggaag gcaactgacc caggaagact cctgctgtgt 240 gatgactgtg acataagtta tcacacctac tgcctagacc ctccattgca gacagttccc 300 aaaggaggct ggaagtgcaa atggtgtgtt tggtgcagac actgtggagc aacatctgca 360 ggtctaagat gtgaatggca gaacaattac acacagtgcg ctccttgtgc aagcttatct 420 tcctgtccag tctgctatcg aaactataga gaagaagatc ttattctgca atgtagacaa 480 tgtgatagat ggatgcatgc agtttgtcag aacttaaata ctgaggaaga agtggaaaat 540 gtagcagaca ttggttttga ttgtagcatg tgcagaccct atatgcctgc gtctaatgtg 600 ccttcctcag actgctgtga atcttcactt gtagcacaaa ttgtcacaaa agtaaaagag 660 ctagacccac ccaagactta tacccaggat ggtgtgtgtt tgactgaatc agggatgact 720 cagttacaga gcctcacagt tacagttcca agaagaaaac ggtcaaaacc aaaattgaaa 780 ttgaagatta taaatcagaa tagcgtggcc gtccttcaga cccctccaga catccaatca 840 gagcattcaa gggatggtga aatggatgat agtcgagaag gagaacttat ggattgtgat 900 ggaaaatcag aatctagtcc tgagcgggaa gctgtggatg atgaaactaa gggagtggaa 960 ggaacagatg gtgtcaaaaa gagaaaaagg aaaccataca gaccaggtat tggtggattt 1020 atggtgcggc aaagaagtcg aactgggcaa gggaaaacca aaagatctgt gatcagaaaa 1080 gattcctcag gctctatttc cgagcagtta ccttgcagag atgatggctg gagtgagcag 1140 ttaccagata ctttagttga tgaatctgtt tctgttactg aaagcactga aaaaataaag 1200 aagagatacc gaaaaaggaa aaataagctt gaagaaactt tccctgccta tttacaagaa 1260 gctttctttg gaaaagatct tctagataca agtagacaaa gcaagataag tttagataat 1320 ctgtcagaag atggagctca gcttttatat aaaacaaaca tgaacacagg tttcttggat 1380 ccttccttag atccactact tagttcatcc tcggctccaa caaaatctgg aactcacggt 1440 cctgctgatg acccattagc tgatatttct gaagttttaa acacagatga tgacattctt 1500 ggaataattt cagatgatct agcaaaatca gttgatcatt cagatattgg tcctgtcact 1560 gatgatcctt cctctttgcc tcagccaaat gtcaatcaga gttcacgacc attaagtgaa 1620 gaacagctag atgggatcct cagtcctgaa ctagacaaaa tggtcacaga tggagcaatt 1680 cttggaaaat tatataaaat tccagagctt ggcggaaaag atgttgaaga cttatttaca 1740 gctgtactta gtcctgcgaa cactcagcca actccattgc cacagcctcc cccaccaaca 1800 cagctgttgc caatacacaa tcaggatgct ttttcacgga tgcctctcat gaatggcctt 1860 attggatcca gtcctcatct cccacataat tctttgccac ctggaagcgg actgggaact 1920 ttctctgcaa ttgcacaatc ctcttatcct gatgccaggg ataaaaattc agcctttaat 1980 ccaatggcaa gtgatcctaa caactcttgg acatcatcag ctcccactgt ggaaggagaa 2040 aatgacacaa tgtcgaatgc ccagagaagc acgcttaagt gggagaaaga ggaggctctg 2100 ggtgaaatgg caactgttgc cccagttctc tacaccaata ttaatttccc caacttaaag 2160 gaagaattcc ctgattggac tactagagtg aagcaaattg ccaaattgtg gagaaaagca 2220 agctcacaag aaagagcacc atatgtgcaa aaagccagag ataacagagc tgctttacgc 2280 attaataaag tacagatgtc aaatgattcc atgaaaaggc agcaacagca agatagcatt 2340 gatcccagct ctcgtattga ttcggagctt tttaaagatc ctttaaagca aagagaatca 2400 gaacatgaac aggaatggaa atttagacag caaatgcgtc agaaaagtaa gcagcaagct 2460 aaaattgaag ccacacagaa acttgaacag gtgaaaaatg agcagcagca gcagcaacaa 2520 cagcaatttg gttctcagca tcttctggtg cagtctggtt cagatacacc aagtagtggg 2580 atacagagtc ccttgacacc tcagcctggc aatggaaata tgtctcctgc acagtcattc 2640 cataaagaac tgtttacaaa acagccaccc agtaccccta cgtctacatc ttcagatgat 2700 gtgtttgtaa agccacaagc tccacctcct cctccagccc catcccggat tcccatccag 2760 gatagtcttt ctcaggctca gacttctcag ccaccctcac cgcaagtgtt ttcacctggg 2820 tcctctaact cacgaccacc atctccaatg gatccatatg caaaaatggt tggtacccct 2880 cgaccacctc ctgtgggcca tagtttttcc agaagaaatt ctgctgcacc agtggaaaac 2940 tgtacacctt tatcatcggt atctaggccc cttcaaatga atgagacaac agcaaatagg 3000 ccatcccctg tcagagattt atgttcttct tccacgacaa ataatgaccc ctatgcaaaa 3060 cctccagaca cacctaggcc tgtgatgaca gatcaatttc ccaaatcctt gggcctatcc 3120 cggtctcctg tagtttcaga acaaactgca aaaggcccta tagcagctgg aaccagtgat 3180 cactttacta aaccatctcc tagggcagat gtgtttcaaa gacaaaggat acctgactca 3240 tatgcacgac ccttgttgac acctgcacct cttgatagtg gtcctggacc ttttaagact 3300 ccaatgcaac ctcctccatc ctctcaggat ccttatggat cagtgtcaca ggcatcaagg 3360 cgattgtctg ttgaccctta tgaaaggcct gctttgacac caagacctat agataatttt 3420 tctcataatc agtcaaatga tccatatagt cagcctcccc ttaccccaca tccagcagtg 3480 aatgaatctt ttgcccatcc ttcaagggct ttttcccagc ctggaaccat atcaaggcca 3540 acatctcagg acccatactc ccaaccccca ggaactccac gacctgttgt agattcttat 3600 tcccaatctt caggaacagc taggtccaat acagaccctt actctcaacc tcctggaact 3660 ccccggccta ctactgttga cccatatagt cagcagcccc aaaccccaag accatctaca 3720 caaactgact tgtttgttac acctgtaaca aatcagaggc attctgatcc atatgctcat 3780 cctcctggaa caccaagacc tggaatttct gtcccttact ctcagccacc agcaacacca 3840 aggccaagga tttcagaggg ttttactagg tcctcaatga caagaccagt cctcatgcca 3900 aatcaggatc ctttcctgca agcagcacaa aaccgaggac cagctttacc tggcccgttg 3960 gtaaggccac ctgatacatg ttcccagaca cctaggcccc ctggacctgg tctttcagac 4020 acatttagcc gtgtttcccc atctgctgcc cgtgatccct atgatcagtc tccaatgact 4080 ccaagatctc agtctgactc ttttggaaca agtcaaactg cccatgatgt tgctgatcag 4140 ccaaggcctg gatcagaggg gagcttctgt gcatcttcaa actctccaat gcactcccaa 4200 ggccagcagt tctctggtgt ctcccaactt cctggacctg tgccaacttc aggagtaact 4260 gatacacaga atactgtaaa tatggcccaa gcagatacag agaaattgag acagcggcag 4320 aagttacgtg aaatcattct ccagcagcaa cagcagaaga agattgcagg tcgacaggag 4380 aaggggtcac aggactcacc cgcagtgcct catccagggc ctcttcaaca ctggcaacca 4440 gagaatgtta accaggcttt caccagaccc ccacctccct atcctgggaa cattaggtct 4500 cctgttgccc ctcctttagg acctagatat gctgttttcc caaaagatca gcgtggaccc 4560 tatcctcctg atgttgctag tatggggatg agacctcatg gatttagatt tggatttcca 4620 ggaggtagtc atggtaccat gccgagtcaa gagcgcttcc ttgtgcctcc tcagcaaata 4680 cagggatctg gagtttctcc acagctaaga agatcagtat ctgtagatat gcctaggcct 4740 ttaaataact cacaaatgaa taatccagtt ggacttcctc agcatttttc accacagagc 4800 ttgccagttc agcagcacaa catactgggc caagcatata ttgaactgag acatagggct 4860 cctgacggaa ggcaacggct gcctttcagt gctccacctg gcagcgttgt agaggcatct 4920 tctaatctga gacatggaaa cttcattccc cggccagact ttccgggccc tagacacaca 4980 gaccccatgc gacgacctcc ccagggtcta cctaatcagc tacctgtgca cccagatttg 5040 gaacaagtgc caccatctca acaagagcaa ggtcattctg tccattcatc ttctatggtc 5100 atgaggactc tgaaccatcc actaggtggt gaattttcag aagctccttt gtcaacatct 5160 gtaccgtctg aaacaacgtc tgataattta cagataacca cccagccttc tgatggtcta 5220 gaggaaaaac ttgattctga tgacccttct gtgaaggaac tggatgttaa agaccttgag 5280 ggggttgaag tcaaagactt agatgatgaa gatcttgaaa acttaaattt agatacagag 5340 gatggcaagg tagttgaatt ggatacttta gataatttgg aaactaatga tcccaacctg 5400 gatgacctct taaggtcagg agagtttgat atcattgcat atacagatcc agaacttgac 5460 atgggagata agaaaagcat gtttaatgag gaactagacc ttccaattga tgataagtta 5520 gataatcagt gtgtatctgt tgaaccaaaa aaaaaggaac aagaaaacaa aactctggtt 5580 ctctctgata aacattcacc acagaaaaaa tccactgtta ccaatgaggt aaaaacggaa 5640 gtactgtctc caaattctaa ggtggaatcc aaatgtgaaa ctgaaaaaaa tgatgagaat 5700 aaagataatg ttgacactcc ttgctcacag gcttctgctc actcagacct aaatgatgga 5760 gaaaagactt ctttgcatcc ttgtgatcca gatctatttg agaaaagaac caatcgagaa 5820 actgctggcc ccagtgcaaa tgtcattcag gcatccactc aactacctgc tcaagatgta 5880 ataaactctt gtggcataac tggatcaact ccagttctct caagtttact tgctaatgag 5940 aaatctgata attcagacat taggccatcg gggtctccac caccaccaac tctgccggcc 6000 tccccatcca atcatgtgtc aagtttgcct cctttcatag caccgcctgg ccgtgttttg 6060 gataatgcca tgaattctaa tgtgacagta gtctctaggg taaaccatgt tttttctcag 6120 ggtgtgcagg taaacccagg gctcattcca ggtcaatcaa cagttaacca cagtctgggg 6180 acaggaaaac ctgcaactca aactgggcct caaacaagtc agtctggtac cagtagcatg 6240 tctggacccc aacagctaat gattcctcaa acattagcac agcagaatag agagaggccc 6300 cttcttctag aagaacagcc tctacttcta caggatcttt tggatcaaga aaggcaagaa 6360 cagcagcagc aaagacagat gcaagccatg attcgtcagc gatcagaacc gttcttccct 6420 aatattgatt ttgatgcaat tacagatcct ataatgaaag ccaaaatggt ggcccttaaa 6480 ggtataaata aagtgatggc acaaaacaat ctgggcatgc caccaatggt gatgagcagg 6540 ttccctttta tgggccaggt ggtaactgga acacagaaca gtgaaggaca gaaccttgga 6600 ccacaggcca ttcctcagga tggcagtata acacatcaga tttctaggcc taatcctcca 6660 aattttggtc caggctttgt caatgattca cagcgtaagc agtatgaaga gtggctccag 6720 gagacccaac agctgcttca aatgcagcag aagtatcttg aagaacaaat tggtgctcac 6780 agaaaatcta agaaggccct ttcagctaaa caacgtactg ccaagaaagc tgggcgtgaa 6840 tttccagagg aagatgcaga acaactcaag catgttactg aacagcaaag catggttcag 6900 aaacagctag aacagattcg taaacaacag aaagaacatg ctgaattgat tgaagattat 6960 cggatcaaac agcagcagca atgtgcaatg gccccaccta ccatgatgcc cagtgtccag 7020 ccccagccac ccctaattcc aggtgccact ccacccacca tgagccaacc cacctttccc 7080 atggtgccac agcagcttca gcaccagcag cacacaacag ttatttctgg ccatactagc 7140 cctgttagaa tgcccagttt acctggatgg caacccaaca gtgctcctgc ccacctgccc 7200 ctcaatcctc ctagaattca gcccccaatt gcccagttac caataaaaac ttgtacacca 7260 gccccaggga cagtctcaaa tgcaaatcca cagagtggac caccacctcg ggtagaattt 7320 gatgacaaca atccctttag tgaaagtttt caagaacggg aacgtaagga acgtttacga 7380 gaacagcaag agagacaacg gatccaactc atgcaggagg tagatagaca aagagctttg 7440 cagcagagga tggaaatgga gcagcatggt atggtgggct ctgagataag tagtagtagg 7500 acatctgtgt cccagattcc cttctacagt tccgacttac cttgtgattt tatgcaacct 7560 ctaggacccc ttcagcagtc tccacaacac caacagcaaa tggggcaggt tttacagcag 7620 cagaatatac aacaaggatc aattaattca ccctccaccc aaactttcat gcagactaat 7680 gagcgaaggc aggtaggccc tccttcattt gttcctgatt caccatcaat ccctgttgga 7740 agcccaaatt tttcttctgt gaagcaggga catggaaatc tttctgggac cagcttccag 7800 cagtccccag tgaggccttc ttttacacct gctttaccag cagcacctcc agtagctaat 7860 agcagtctcc catgtggcca agattctact ataacccatg gacacagtta tccgggatca 7920 acccaatcgc tcattcagtt gtattctgat ataatcccag aggaaaaagg gaaaaagaaa 7980 agaacaagaa agaagaaaag agatgatgat gcagaatcca ccaaggctcc atcaactccc 8040 cattcagata taactgcccc accgactcca ggcatctcag aaactacctc tactcctgca 8100 gtgagcacac ccagtgagct tcctcaacaa gccgaccaag agtcggtgga accagtcggc 8160 ccatccactc ccaatatggc agcaggccag ctatgtacag aattagagaa caaactgccc 8220 aatagtgatt tctcacaagc aactccaaat caacagacgt atgcaaattc agaagtagac 8280 aagctctcca tggaaacccc tgccaaaaca gaagagataa aactggaaaa ggctgagaca 8340 gagtcctgcc caggccaaga ggagcctaaa ttggaggaac agaatggtag taaggtagaa 8400 ggaaacgctg tagcctgtcc tgtctcctca gcacagagtc ctccccattc tgctggggcc 8460 cctgctgcca aaggagactc agggaatgaa cttctgaaac acttgttgaa aaataaaaag 8520 tcatcttctc ttttgaatca aaaacctgag ggcagtattt gttcagaaga tgactgtaca 8580 aaggataata aactagttga gaagcagaac ccagctgaag gactgcaaac tttgggggct 8640 caaatgcaag gtggttttgg atgtggcaac cagttgccaa aaacagatgg aggaagtgaa 8700 accaagaaac agcgaagcaa acggactcag aggacgggtg agaaagcagc acctcgctca 8760 aagaaaagga aaaaggacga agaggagaaa caagctatgt actctagcac tgacacgttt 8820 acccacttga aacaggtgag gcagctctct ctgctccctc taatggaacc aatcattgga 8880 gtgaactttg cgcactttct tccttatggc agtggccaat ttaatagtgg gaatcgactt 8940 ctaggaactt ttggcagtgc taccctggaa ggggtttcgg actactattc tcagttgatc 9000 tacaagcaga ataatttaag taatcctcca acaccccctg cctctcttcc tcctacacca 9060 cctcctatgg cttgtcagaa gatggccaat ggttttgcaa caactgaaga acttgctgga 9120 aaagccggag tgttagtgag ccatgaagtt accaaaactc taggacctaa accatttcag 9180 ctgcccttca gaccccagga cgacttgttg gcccgagctc ttgctcaggg ccccaagaca 9240 gttgatgtgc cagcctccct cccaacacca cctcataaca atcaggaaga attaaggata 9300 caggatcact gtggtgatcg agatactcct gacagttttg ttccctcatc ctctcctgag 9360 agtgtggttg gggtagaagt gagcaggtat ccagatctgt cattggtcaa ggaggagcct 9420 ccagaaccgg tgccgtcccc catcattcca attcttccta gcactgctgg gaaaagttca 9480 gaatcaagaa ggaatgacat caaaactgag ccaggcactt tatattttgc gtcacctttt 9540 ggtccttccc caaatggtcc cagatcaggt cttatatctg tagcaattac tctgcatcct 9600 acagctgctg agaacattag cagtgttgtg gctgcatttt ccgaccttct tcacgtccga 9660 atccctaaca gctatgaggt tagcagtgct ccagatgtcc catccatggg tttggtcagt 9720 agccacagaa tcaacccggg tttggagtat cgacagcatt tacttctccg tgggcctccg 9780 ccaggatctg caaaccctcc cagattagtg agctcttacc ggctgaagca gcctaatgta 9840 ccatttcctc caacaagcaa tggtctttct ggatataagg attctagtca tggtattgca 9900 gaaagcgcag cactcagacc acagtggtgt tgtcattgta aagtggttat tcttggaagt 9960 ggtgtgcgga aatctttcaa agatctgacc cttttgaaca aggattcccg agaaagcacc 10020 aagagggtag agaaggacat tgtcttctgt agtaataact gctttattct ttattcatca 10080 actgcacaag cgaaaaactc agaaaacaag gaatccattc cttcattgcc acaatcacct 10140 atgagagaaa cgccttccaa agcatttcat cagtacagca acaacatctc cactttggat 10200 gtgcactgtc tcccccagct cccagagaaa gcttctcccc ctgcctcacc acccatcgcc 10260 ttccctcctg cttttgaagc agcccaagtc gaggccaagc cagatgagct gaaggtgaca 10320 gtcaagctga agcctcggct aagagctgtc catggtgggt ttgaagattg caggccgctc 10380 aataaaaaat ggagaggaat gaaatggaag aagtggagca ttcatattgt aatccctaag 10440 gggacattta aaccaccttg tgaggatgaa atagatgaat ttctaaagaa attgggcact 10500 tcccttaaac ctgatcctgt gcccaaagac tatcggaaat gttgcttttg tcatgaagaa 10560 ggtgatggat tgacagatgg accagcaagg ctactcaacc ttgacttgga tctgtgggtc 10620 cacttgaact gcgctctgtg gtccacggag gtctatgaga ctcaggctgg tgccttaata 10680 aatgtggagc tagctctgag gagaggccta caaatgaaat gtgtcttctg tcacaagacg 10740 ggtgccacta gtggatgcca cagatttcga tgcaccaaca tttatcactt cacttgcgcc 10800 attaaagcac aatgcatgtt ttttaaggac aaaactatgc tttgccccat gcacaaacca 10860 aagggaattc atgagcaaga attaagttac tttgcagtct tcaggagggt ctatgttcag 10920 cgtgatgagg tgcgacagat tgctagcatc gtgcaacgag gagaacggga ccataccttt 10980 cgcgtgggta gcctcatctt ccacacaatt ggtcagctgc ttccacagca gatgcaagca 11040 ttccattctc ctaaagcact cttccctgtg ggctatgaag ccagccggct gtactggagc 11100 actcgctatg ccaataggcg ctgccgctac ctgtgctcca ttgaggagaa ggatgggcgc 11160 ccagtgtttg tcatcaggat tgtggaacaa ggccatgaag acctggttct aagtgacatc 11220 tcacctaaag gtgtctggga taagattttg gagcctgtgg catgtgtgag aaaaaagtct 11280 gaaatgctcc agcttttccc agcgtattta aaaggagagg atctgtttgg cctgaccgtc 11340 tctgcagtgg cacgcatagc ggaatcactt cctggggttg aggcatgtga aaattatacc 11400 ttccgatacg gccgaaatcc tctcatggaa cttcctcttg ccgttaaccc cacaggttgt 11460 gcccgttctg aacctaaaat gagtgcccat gtcaagaggc ctcacacctt aaacagcacc 11520 agcacctcaa agtcatttca gagcacagtc actggagaac tgaacgcacc ttatagtaaa 11580 cagtttgttc actccaagtc atcgcagtac cggaagatga aaactgaatg gaaatccaat 11640 gtgtatctgg cacggtctcg gattcagggg ctgggcctgt atgctgctcg agacattgag 11700 aaacacacca tggtcattga gtacatcggg actatcattc gaaacgaagt agccaacagg 11760 aaagagaagc tttatgagtc tcagaaccgt ggtgtgtaca tgttccgcat ggataacgac 11820 catgtgattg acgcgacgct cacaggaggg cccgcaaggt atatcaacca ttcgtgtgca 11880 cctaattgtg tggctgaagt ggtgactttt gagagaggac acaaaattat catcagctcc 11940 agtcggagaa tccagaaagg agaagagctc tgctatgact ataagtttga ctttgaagat 12000 gaccagcaca agattccgtg tcactgtgga gctgtgaact gccggaagtg gatgaactga 12060 aatgcattcc ttgctagctc agcgggcggc ttgtccctag gaagaggcga ttcaacacac 12120 cattggaatt ttgcagacag aaagagattt ttgttttctg ttttatgact ttttgaaaaa 12180 gcttctggga gttctgattt cctcagtcct ttaggttaaa gcagcgccag gaggaagctg 12240 acagaagcag cgttcctgaa gtggccgagg ttaaacggaa tcacagaatg gtccagcact 12300 tttgcttt 12308 <210> 423 <211> 596 <212> DNA <213> Homo (Homo sapiens) <400> 423 ggccggtgaa ggaccgcgag gccttccaga ggctcaactt cctgtaccag gtgagtctgc 60 gacaagggcc ccacggggac ggtgctcggc gtcccagagt gactgctccc ctcccgcagg 120 ccgcccattg tgtccttgcc caggaccccg agaaccaggc gctggcgagg ttttactgct 180 acactgagag gaccattgcg aagcggctcg tcttgcggcg ggatccctcg gtgaagagga 240 ctctctgtcg aggctgctct tccctcctcg tcccgggcct cacctgcacc caccgccaga 300 gacgctgcag gggacagcgc tggaccgtac agacctgcct aacatgccag cgcagccaac 360 gcttcctcaa tgatcccggg catttactct ggggagacag gcctgaggcc cagctcggga 420 gccaagcaga ttccaaacca ctacaaccct tgccaaacac agcccactcc atttcagacc 480 gccttcctga ggagaaaatg cagactcagg gttccagtaa ccagtgatgg attcacccca 540 tctcccaaat aaagtttact tgttttacat tcaaaaaaaa aaaaaaaaaa ctcgag 596 <210> 424 <211> 1549 <212> DNA <213> Homo (Homo sapiens) <400> 424 tgtgagaccg ccaagatggt ggtgggcgcg ttccctatgg cgaagctgct atacttgggc 60 atccggcagg tcagcaagcc gcttgccaac cgtattaagg aggccgcccg ccgaagcgag 120 ttcttcaaga cctatatctg cctcccgccg gctcaactgt atcactgggt ggagatgcgg 180 accaagatgc gcatcatggg cttccggggc acggtcatca agccgctgaa cgaggaggcg 240 gcagccgagc tgggcgcaga gctgctgggc gaagccacca tcttcatcgt gggcggcggc 300 tgcctagtgc tggagtactg gcgccaccag gcgcagcagc gccacaagga ggaggagcag 360 cgtgctgcct ggaacgcgct gcgggacgag gtgggccacc tggcgctggc gctggaagcg 420 ctgcaggcgc aggtgcaggc ggcgccgcca cagggcgccc tggaggaact gcgcacagag 480 ctgcaagagg tgcgcgccca gctctgcaat cccggccggt ccgcttccca cgcagtgcct 540 gcgtccaaga aataggagct tgctggatgg aacctgaatt tggacatggc ctatgtacct 600 aacgtggcct tcttcccgca ccacccttgc ctgcgctggc ccagtggaaa ccaccaggat 660 cttgatgcaa cttggcattt ggttacccct gctgataaga gcagccatta cctgccactg 720 ggaccagcag gtgaagcgtt gcaacatagc cccctccatc atccttcacc tcctatcccc 780 cactccaaac caggacgacc tgcaaggtcc cagccagcag gacaccgtgg gcactctggc 840 aaatgaaaaa atggaacctg gtcttgagct gaatcaatgt gttattgtta cccccacccc 900 cggtttacct gatcagtgtt aacctttact gggacactca tctgttacac tggaacacct 960 tcttcttttt gtcaatcggc acagaccact gtaaggaaat gcagtgtgtt gcagtggcct 1020 tttctccccc tcaccttcta aggtcagctc tagctgagca tcagtgctct cttaaggagg 1080 aaaaaaacgg tgcggctggg agcggtggct cacgcctgta atcctagcac cttgggaggc 1140 cgaggcgggc ggatcacttg aggtcaggag ttccagacca gcctggccaa catggtgaaa 1200 ctccgtctct actaaaaata caaaaattag ccgggtgtgg tggggtgcgc ttgtaatccc 1260 agctactcgg gaggctgagg caggagaatt gcttgaaccc atgaggtgga ggttgcggtg 1320 agccaagatg gcaccattgc accctagcct gggcaacaga gcaagacacc gtcttaaaac 1380 caaaagttaa ccgggcgtgg tggtgggtgc ctgtaatcct agctacttgg gaggctgagg 1440 caggagaatt gcttgaactt gggaggtgga ggccaagatt gtaccactgt attccagccc 1500 gggtgacaga gcaagactgt gtctcaaaaa aaaaaaaaaa aaactcgag 1549 <210> 425 <211> 4019 <212> PRT <213> Homo (Homo sapiens) <400> 425 Leu Phe Ser Ser Ser Asp Lys Phe Thr Leu Asn Gln Asp Met Cys Val ...

5??????????????????10??????????????????15Val?Cys?Gly?Ser?Phe?Gly?Gln?Gly?Ala?Glu?Gly?Arg?Leu?Leu?Ala?Cys

20??????????????????25??????????????????30Ser?Gln?Cys?Gly?Gln?Cys?Tyr?His?Pro?Tyr?Cys?Val?Ser?Ile?Lys?Ile

35??????????????????40??????????????????45Thr?Lys?Val?Val?Leu?Ser?Lys?Gly?Trp?Arg?Cys?Leu?Glu?Cys?Thr?Val

50??????????????????55??????????????????60Cys?Glu?Ala?Cys?Gly?Lys?Ala?Thr?Asp?Pro?Gly?Arg?Leu?Leu?Leu?Cys?65??????????????????70??????????????????75??????????????????80Asp?Asp?Cys?Asp?Ile?Ser?Tyr?His?Thr?Tyr?Cys?Leu?Asp?Pro?Pro?Leu

85??????????????????90??????????????????95Gln?Thr?Val?Pro?Lys?Gly?Gly?Trp?Lys?Cys?Lys?Trp?Cys?Val?Trp?Cys

100?????????????????105?????????????????110Arg?His?Cys?Gly?Ala?Thr?Ser?Ala?Gly?Leu?Arg?Cys?Glu?Trp?Gln?Asn

115?????????????????120?????????????????125Asn?Tyr?Thr?Gln?Cys?Ala?Pro?Cys?Ala?Ser?Leu?Ser?Ser?Cys?Pro?Val

130?????????????????135?????????????????140Cys?Tyr?Arg?Asn?Tyr?Arg?Glu?Glu?Asp?Leu?Ile?Leu?Gln?Cys?Arg?Gln145?????????????????150?????????????????155?????????????????160Cys?Asp?Arg?Trp?Met?His?Ala?Val?Cys?Gln?Asn?Leu?Asn?Thr?Glu?Glu

165?????????????????170?????????????????175Glu?Val?Glu?Asn?Val?Ala?Asp?Ile?Gly?Phe?Asp?Cys?Ser?Met?Cys?Arg

180?????????????????185?????????????????190Pro?Tyr?Met?Pro?Ala?Ser?Asn?Val?Pro?Ser?Ser?Asp?Cys?Cys?Glu?Ser

195?????????????????200?????????????????205Ser?Leu?Val?Ala?Gln?Ile?Val?Thr?Lys?Val?Lys?Glu?Leu?Asp?Pro?Pro

210?????????????????215?????????????????220Lys?Thr?Tyr?Thr?Gln?Asp?Gly?Val?Cys?Leu?Thr?Glu?Ser?Gly?Met?Thr225?????????????????230?????????????????235?????????????????240Gln?Leu?Gln?Ser?Leu?Thr?Val?Thr?Val?Pro?Arg?Arg?Lys?Arg?Ser?Lys

245?????????????????250?????????????????255Pro?Lys?Leu?Lys?Leu?Lys?Ile?Ile?Asn?Gln?Asn?Ser?Val?Ala?Val?Leu

260?????????????????265?????????????????270Gln?Thr?Pro?Pro?Asp?Ile?Gln?Ser?Glu?His?Ser?Arg?Asp?Gly?Glu?Met

275?????????????????280?????????????????285Asp?Asp?Ser?Arg?Glu?Gly?Glu?Leu?Met?Asp?Cys?Asp?Gly?Lys?Ser?Glu

290?????????????????295?????????????????300Ser?Ser?Pro?Glu?Arg?Glu?Ala?Val?Asp?Asp?Glu?Thr?Lys?Gly?Val?Glu305?????????????????310?????????????????315?????????????????320Gly?Thr?Asp?Gly?Val?Lys?Lys?Arg?Lys?Arg?Lys?Pro?Tyr?Arg?Pro?Gly

325?????????????????330?????????????????335Ile?Gly?Gly?Phe?Met?Val?Arg?Gln?Arg?Ser?Arg?Thr?Gly?Gln?Gly?Lys

340?????????????????345?????????????????350Thr?Lys?Arg?Ser?Val?Ile?Arg?Lys?Asp?Ser?Ser?Gly?Ser?Ile?Ser?Glu

355?????????????????360?????????????????365Gln?Leu?Pro?Cys?Arg?Asp?Asp?Gly?Trp?Ser?Glu?Gln?Leu?Pro?Asp?Thr

370?????????????????375?????????????????380Leu?Val?Asp?Glu?Ser?Val?Ser?Val?Thr?Glu?Ser?Thr?Glu?Lys?Ile?Lys385?????????????????390?????????????????395?????????????????400Lys?Arg?Tyr?Arg?Lys?Arg?Lys?Asn?Lys?Leu?Glu?Glu?Thr?Phe?Pro?Ala

405?????????????????410?????????????????415Tyr?Leu?Gln?Glu?Ala?Phe?Phe?Gly?Lys?Asp?Leu?Leu?Asp?Thr?Ser?Arg

420?????????????????425?????????????????430Gln?Ser?Lys?Ile?Ser?Leu?Asp?Asn?Leu?Ser?Glu?Asp?Gly?Ala?Gln?Leu

435?????????????????440?????????????????445Leu?Tyr?Lys?Thr?Asn?Met?Asn?Thr?Gly?Phe?Leu?Asp?Pro?Ser?Leu?Asp

450?????????????????455?????????????????460Pro?Leu?Leu?Ser?Ser?Ser?Ser?Ala?Pro?Thr?Lys?Ser?Gly?Thr?His?Gly465?????????????????470?????????????????475?????????????????480Pro?Ala?Asp?Asp?Pro?Leu?Ala?Asp?Ile?Ser?Glu?Val?Leu?Asn?Thr?Asp

485?????????????????490?????????????????495Asp?Asp?Ile?Leu?Gly?Ile?Ile?Ser?Asp?Asp?Leu?Ala?Lys?Ser?Val?Asp

500?????????????????505?????????????????510His?Ser?Asp?Ile?Gly?Pro?Val?Thr?Asp?Asp?Pro?Ser?Ser?Leu?Pro?Gln

515?????????????????520?????????????????525Pro?Asn?Val?Asn?Gln?Ser?Ser?Arg?Pro?Leu?Ser?Glu?Glu?Gln?Leu?Asp

530?????????????????535?????????????????540Gly?Ile?Leu?Ser?Pro?Glu?Leu?Asp?Lys?Met?Val?Thr?Asp?Gly?Ala?Ile545?????????????????550?????????????????555?????????????????560Leu?Gly?Lys?Leu?Tyr?Lys?Ile?Pro?Glu?Leu?Gly?Gly?Lys?Asp?Val?Glu

565?????????????????570?????????????????575Asp?Leu?Phe?Thr?Ala?Val?Leu?Ser?Pro?Ala?Asn?Thr?Gln?Pro?Thr?Pro

580?????????????????585?????????????????590Leu?Pro?Gln?Pro?Pro?Pro?Pro?Thr?Gln?Leu?Leu?Pro?Ile?His?Asn?Gln

595?????????????????600?????????????????605Asp?Ala?Phe?Ser?Arg?Met?Pro?Leu?Met?Asn?Gly?Leu?Ile?Gly?Ser?Ser

610?????????????????615?????????????????620Pro?His?Leu?Pro?His?Asn?Ser?Leu?Pro?Pro?Gly?Ser?Gly?Leu?Gly?Thr625?????????????????630?????????????????635?????????????????640Phe?Ser?Ala?Ile?Ala?Gln?Ser?Ser?Tyr?Pro?Asp?Ala?Arg?Asp?Lys?Asn

645?????????????????650?????????????????655Ser?Ala?Phe?Asn?Pro?Met?Ala?Ser?Asp?Pro?Asn?Asn?Ser?Trp?Thr?Ser

660?????????????????665?????????????????670Ser?Ala?Pro?Thr?Val?Glu?Gly?Glu?Asn?Asp?Thr?Met?Ser?Asn?Ala?Gln

675?????????????????680?????????????????685Arg?Ser?Thr?Leu?Lys?Trp?Glu?Lys?Glu?Glu?Ala?Leu?Gly?Glu?Met?Ala

690?????????????????695?????????????????700Thr?Val?Ala?Pro?Val?Leu?Tyr?Thr?Asn?Ile?Asn?Phe?Pro?Asn?Leu?Lys705?????????????????710?????????????????715?????????????????720Glu?Glu?Phe?Pro?Asp?Trp?Thr?Thr?Arg?Val?Lys?Gln?Ile?Ala?Lys?Leu

725?????????????????730?????????????????735Trp?Arg?Lys?Ala?Ser?Ser?Gln?Glu?Arg?Ala?Pro?Tyr?Val?Gln?Lys?Ala

740?????????????????745?????????????????750Arg?Asp?Asn?Arg?Ala?Ala?Leu?Arg?Ile?Asn?Lys?Val?Gln?Met?Ser?Asn

755?????????????????760?????????????????765Asp?Ser?Met?Lys?Arg?Gln?Gln?Gln?Gln?Asp?Ser?Ile?Asp?Pro?Ser?Ser

770?????????????????775?????????????????780Arg?Ile?Asp?Ser?Glu?Leu?Phe?Lys?Asp?Pro?Leu?Lys?Gln?Arg?Glu?Ser785?????????????????790?????????????????795?????????????????800Glu?His?Glu?Gln?Glu?Trp?Lys?Phe?Arg?Gln?Gln?Met?Arg?Gln?Lys?Ser

805?????????????????810?????????????????815Lys?Gln?Gln?Ala?Lys?Ile?Glu?Ala?Thr?Gln?Lys?Leu?Glu?Gln?Val?Lys

820?????????????????825?????????????????830Asn?Glu?Gln?Gln?Gln?Gln?Gln?Gln?Gln?Gln?Phe?Gly?Ser?Gln?His?Leu

835?????????????????840?????????????????845Leu?Val?Gln?Ser?Gly?Ser?Asp?Thr?Pro?Ser?Ser?Gly?Ile?Gln?Ser?Pro

850?????????????????855?????????????????860Leu?Thr?Pro?Gln?Pro?Gly?Asn?Gly?Asn?Met?Ser?Pro?Ala?Gln?Ser?Phe865?????????????????870?????????????????875?????????????????880His?Lys?Glu?Leu?Phe?Thr?Lys?Gln?Pro?Pro?Ser?Thr?Pro?Thr?Ser?Thr

885?????????????????890?????????????????895Ser?Ser?Asp?Asp?Val?Phe?Val?Lys?Pro?Gln?Ala?Pro?Pro?Pro?Pro?Pro

900?????????????????905?????????????????910Ala?Pro?Ser?Arg?Ile?Pro?Ile?Gln?Asp?Ser?Leu?Ser?Gln?Ala?Gln?Thr

915?????????????????920?????????????????925Ser?Gln?Pro?Pro?Ser?Pro?Gln?Val?Phe?Ser?Pro?Gly?Ser?Ser?Asn?Ser

930?????????????????935?????????????????940Arg?Pro?Pro?Ser?Pro?Met?Asp?Pro?Tyr?Ala?Lys?Met?Val?Gly?Thr?Pro945?????????????????950?????????????????955?????????????????960Arg?Pro?Pro?Pro?Val?Gly?His?Ser?Phe?Ser?Arg?Arg?Asn?Ser?Ala?Ala

965?????????????????970?????????????????975Pro?Val?Glu?Asn?Cys?Thr?Pro?Leu?Ser?Ser?Val?Ser?Arg?Pro?Leu?Gln

980?????????????????985?????????????????990Met?Asn?Glu?Thr?Thr?Ala?Asn?Arg?Pro?Ser?Pro?Val?Arg?Asp?Leu?Cys

995?????????????????1000????????????????1005Ser?Ser?Ser?Thr?Thr?Asn?Asn?Asp?Pro?Tyr?Ala?Lys?Pro?Pro?Asp?Thr

1010????????????????1015????????????????1020Pro?Arg?Pro?Val?Met?Thr?Asp?Gln?Phe?Pro?Lys?Ser?Leu?Gly?Leu?Ser1025????????????????1030????????????????1035????????????????1040Arg?Ser?Pro?Val?Val?Ser?Glu?Gln?Thr?Ala?Lys?Gly?Pro?Ile?Ala?Ala

1045????????????????1050????????????????1055Gly?Thr?Ser?Asp?His?Phe?Thr?Lys?Pro?Ser?Pro?Arg?Ala?Asp?Val?Phe

1060????????????????1065????????????????1070Gln?Arg?Gln?Arg?Ile?Pro?Asp?Ser?Tyr?Ala?Arg?Pro?Leu?Leu?Thr?Pro

1075????????????????1080????????????????1085Ala?Pro?Leu?Asp?Ser?Gly?Pro?Gly?Pro?Phe?Lys?Thr?Pro?Met?Gln?Pro

1090????????????????1095????????????????1100Pro?Pro?Ser?Ser?Gln?Asp?Pro?Tyr?Gly?Ser?Val?Ser?Gln?Ala?Ser?Arg1105????????????????1110????????????????1115????????????????1120Arg?Leu?Ser?Val?Asp?Pro?Tyr?Glu?Arg?Pro?Ala?Leu?Thr?Pro?Arg?Pro

1125????????????????1130????????????????1135Ile?Asp?Asn?Phe?Ser?His?Asn?Gln?Ser?Asn?Asp?Pro?Tyr?Ser?Gln?Pro

1140????????????????1145????????????????1150Pro?Leu?Thr?Pro?His?Pro?Ala?Val?Asn?Glu?Ser?Phe?Ala?His?Pro?Ser

1155????????????????1160????????????????1165Arg?Ala?Phe?Ser?Gln?Pro?Gly?Thr?Ile?Ser?Arg?Pro?Thr?Ser?Gln?Asp

1170????????????????1175????????????????1180Pro?Tyr?Ser?Gln?Pro?Pro?Gly?Thr?Pro?Arg?Pro?Val?Val?Asp?Ser?Tyr1185????????????????1190????????????????1195????????????????1200Ser?Gln?Ser?Ser?Gly?Thr?Ala?Arg?Ser?Asn?Thr?Asp?Pro?Tyr?Ser?Gln

1205????????????????1210????????????????1215Pro?Pro?Gly?Thr?Pro?Arg?Pro?Thr?Thr?Val?Asp?Pro?Tyr?Ser?Gln?Gln

1220????????????????1225????????????????1230Pro?Gln?Thr?Pro?Arg?Pro?Ser?Thr?Gln?Thr?Asp?Leu?Phe?Val?Thr?Pro

1235????????????????1240????????????????1245Val?Thr?Asn?Gln?Arg?His?Ser?Asp?Pro?Tyr?Ala?His?Pro?Pro?G1y?Thr

1250????????????????1255????????????????1260Pro?Arg?Pro?Gly?Ile?Ser?Val?Pro?Tyr?Ser?Gln?Pro?Pro?Ala?Thr?Pro1265????????????????1270????????????????1275????????????????1280Arg?Pro?Arg?Ile?Ser?Glu?Gly?Phe?Thr?Arg?Ser?Ser?Met?Thr?Arg?Pro

1285????????????????1290????????????????1295Val?Leu?Met?Pro?Asn?Gln?Asp?Pro?Phe?Leu?Gln?Ala?Ala?Gln?Asn?Arg

1300????????????????1305????????????????1310Gly?Pro?Ala?Leu?Pro?Gly?Pro?Leu?Val?Arg?Pro?Pro?Asp?Thr?Cys?Ser

1315????????????????1320????????????????1325Gln?Thr?Pro?Arg?Pro?Pro?Gly?Pro?Gly?Leu?Ser?Asp?Thr?Phe?Ser?Arg

1330????????????????1335????????????????1340Val?Ser?Pro?Ser?Ala?Ala?Arg?Asp?Pro?Tyr?Asp?Gln?Ser?Pro?Met?Thr1345????????????????1350????????????????1355????????????????1360Pro?Arg?Ser?Gln?Ser?Asp?Ser?Phe?Gly?Thr?Ser?Gln?Thr?Ala?His?Asp

1365????????????????1370????????????????1375Val?Ala?Asp?Gln?Pro?Arg?Pro?Gly?Ser?Glu?Gly?Ser?Phe?Cys?Ala?Ser

1380????????????????1385????????????????1390Ser?Asn?Ser?Pro?Met?His?Ser?Gln?Gly?Gln?Gln?Phe?Ser?Gly?Val?Ser

1395????????????????1400????????????????1405Gln?Leu?Pro?Gly?Pro?Val?Pro?Thr?Ser?Gly?Val?Thr?Asp?Thr?Gln?Asn

1410????????????????1415????????????????1420Thr?Val?Asn?Met?Ala?Gln?Ala?Asp?Thr?Glu?Lys?Leu?Arg?Gln?Arg?Gln1425????????????????1430????????????????1435????????????????1440Lys?Leu?Arg?Glu?Ile?Ile?Leu?Gln?Gln?Gln?Gln?Gln?Lys?Lys?Ile?Ala

1445????????????????1450????????????????1455Gly?Arg?Gln?Glu?Lys?Gly?Ser?Gln?Asp?Ser?Pro?Ala?Val?Pro?His?Pro

1460????????????????1465????????????????1470Gly?Pro?Leu?Gln?His?Trp?Gln?Pro?Glu?Asn?Val?Asn?Gln?Ala?Phe?Thr

1475????????????????1480????????????????1485Arg?Pro?Pro?Pro?Pro?Tyr?Pro?Gly?Asn?Ile?Arg?Ser?Pro?Val?Ala??Pro

1490????????????????1495????????????????1500Pro?Leu?Gly?Pro?Arg?Tyr?Ala?Val?Phe?Pro?Lys?Asp?Gln?Arg?Gly?Pro1505????????????????1510????????????????1515????????????????1520Tyr?Pro?Pro?Asp?Val?Ala?Ser?Met?Gly?Met?Arg?Pro?His?Gly?Phe?Arg

1525????????????????1530????????????????1535Phe?Gly?Phe?Pro?Gly?Gly?Ser?His?Gly?Thr?Met?Pro?Ser?Gln?Glu?Arg

1540????????????????1545????????????????1550Phe?Leu?Val?Pro?Pro?Gln?Gln?Ile?Gln?Gly?Ser?Gly?Val?Ser?Pro?Gln

1555????????????????1560????????????????1565Leu?Arg?Arg?Ser?Val?Ser?Val?Asp?Met?Pro?Arg?Pro?Leu?Asn?Asn?Ser

1570????????????????1575????????????????1580Gln?Met?Asn?Asn?Pro?Val?Gly?Leu?Pro?Gln?His?Phe?Ser?Pro?Gln?Ser1585????????????????1590????????????????1595????????????????1600Leu?Pro?Val?Gln?Gln?His?Asn?Ile?Leu?Gly?Gln?Ala?Tyr?Ile?Glu?Leu

1605????????????????1610????????????????1615Arg?His?Arg?Ala?Pro?Asp?Gly?Arg?Gln?Arg?Leu?Pro?Phe?Ser?Ala?Pro

1620????????????????1625????????????????1630Pro?Gly?Ser?Val?Val?Glu?Ala?Ser?Ser?Asn?Leu?Arg?His?Gly?Asn?Phe

1635????????????????1640????????????????1645Ile?Pro?Arg?Pro?Asp?Phe?Pro?Gly?Pro?Arg?His?Thr?Asp?Pro?Met?Arg

1650????????????????1655????????????????1660Arg?Pro?Pro?Gln?Gly?Leu?Pro?Asn?Gln?Leu?Pro?Val?His?Pro?Asp?Leu1665????????????????1670????????????????1675????????????????1680Glu?Gln?Val?Pro?Pro?Ser?Gln?Gln?Glu?Gln?Gly?His?Ser?Val?His?Ser

1685????????????????1690????????????????1695Ser?Ser?Met?Val?Met?Arg?Thr?Leu?Asn?His?Pro?Leu?Gly?Gly?Glu?Phe

1700????????????????1705????????????????1710Ser?Glu?Ala?Pro?Leu?Ser?Thr?Ser?Val?Pro?Ser?Glu?Thr?Thr?Ser?Asp

1715????????????????1720????????????????1725Asn?Leu?Gln?Ile?Thr?Thr?Gln?Pro?Ser?Asp?Gly?Leu?Glu?Glu?Lys?Leu

1730????????????????1735????????????????1740Asp?Ser?Asp?Asp?Pro?Ser?Val?Lys?Glu?Leu?Asp?Val?Lys?Asp?Leu?Glu1745????????????????1750????????????????1755????????????????1760Gly?Val?Glu?Val?Lys?Asp?Leu?Asp?Asp?Glu?Asp?Leu?Glu?Asn?Leu?Asn

1765????????????????1770????????????????1775Leu?Asp?Thr?Glu?Asp?Gly?Lys?Val?Val?Glu?Leu?Asp?Thr?Leu?Asp?Asn

1780????????????????1785????????????????1790Leu?Glu?Thr?Asn?Asp?Pro?Asn?Leu?Asp?Asp?Leu?Leu?Arg?Ser?Gly?Glu

1795????????????????1800????????????????1805Phe?Asp?Ile?Ile?Ala?Tyr?Thr?Asp?Pro?Glu?Leu?Asp?Met?Gly?Asp?Lys

1810????????????????1815????????????????1820Lys?Ser?Met?Phe?Asn?Glu?Glu?Leu?Asp?Leu?Pro?Ile?Asp?Asp?Lys?Leu1825????????????????1830????????????????1835????????????????1840Asp?Asn?Gln?Cys?Val?Ser?Val?Glu?Pro?Lys?Lys?Lys?Glu?Gln?Glu?Asn

1845????????????????1850????????????????1855Lys?Thr?Leu?Val?Leu?Ser?Asp?Lys?His?Ser?Pro?Gln?Lys?Lys?Ser?Thr

1860????????????????1865????????????????1870Val?Thr?Asn?Glu?Val?Lys?Thr?Glu?Val?Leu?Ser?Pro?Asn?Ser?Lys?Val

1875????????????????1880????????????????1885Glu?Ser?Lys?Cys?Glu?Thr?Glu?Lys?Asn?Asp?Glu?Asn?Lys?Asp?Asn?Val

1890????????????????1895????????????????1900Asp?Thr?Pro?Cys?Ser?Gln?Ala?Ser?Ala?His?Ser?Asp?Leu?Asn?Asp?Gly1905????????????????1910????????????????1915????????????????1920Glu?Lys?Thr?Ser?Leu?His?Pro?Cys?Asp?Pro?Asp?Leu?Phe?Glu?Lys?Arg

1925????????????????1930????????????????1935Thr?Asn?Arg?Glu?Thr?Ala?Gly?Pro?Ser?Ala?Asn?Val?Ile?Gln?Ala?Ser

1940????????????????1945????????????????1950Thr?Gln?Leu?Pro?Ala?Gln?Asp?Val?Ile?Asn?Ser?Cys?Gly?Ile?Thr?Gly

1955????????????????1960????????????????1965Ser?Thr?Pro?Val?Leu?Ser?Ser?Leu?Leu?Ala?Asn?Glu?Lys?Ser?Asp?Asn

1970????????????????1975????????????????1980Ser?Asp?Ile?Arg?Pro?Ser?Gly?Ser?Pro?Pro?Pro?Pro?Thr?Leu?Pro?Ala1985????????????????1990????????????????1995????????????????2000Ser?Pro?Ser?Asn?His?Val?Ser?Ser?Leu?Pro?Pro?Phe?Ile?Ala?Pro?Pro

2005????????????????2010????????????????2015Gly?Arg?Val?Leu?Asp?Asn?Ala?Met?Asn?Ser?Asn?Val?Thr?Val?Val?Ser

2020????????????????2025????????????????2030Arg?Val?Asn?His?Val?Phe?Ser?Gln?Gly?Val?Gln?Val?Asn?Pro?Gly?Leu

2035????????????????2040????????????????2045Ile?Pro?Gly?Gln?Ser?Thr?Val?Asn?His?Ser?Leu?Gly?Thr?Gly?Lys?Pro

2050????????????????2055????????????????2060Ala?Thr?Gln?Thr?Gly?Pro?Gln?Thr?Ser?Gln?Ser?Gly?Thr?Ser?Ser?Met2065????????????????2070????????????????2075????????????????2080Ser?Gly?Pro?Gln?Gln?Leu?Met?Ile?Pro?Gln?Thr?Leu?Ala?Gln?Gln?Asn

2085????????????????2090????????????????2095Arg?Glu?Arg?Pro?Leu?Leu?Leu?Glu?Glu?Gln?Pro?Leu?Leu?Leu?Gln?Asp

2100????????????????2105????????????????2110Leu?Leu?Asp?Gln?Glu?Arg?Gln?Glu?Gln?Gln?Gln?Gln?Arg?Gln?Met?Gln

2115????????????????2120????????????????2125Ala?Met?Ile?Arg?Gln?Arg?Ser?Glu?Pro?Phe?Phe?Pro?Asn?Ile?Asp?Phe

2130????????????????2135????????????????2140Asp?Ala?Ile?Thr?Asp?Pro?Ile?Met?Lys?Ala?Lys?Met?Val?Ala?Leu?Lys2145????????????????2150????????????????2155????????????????2160Gly?Ile?Asn?Lys?Val?Met?Ala?Gln?Asn?Asn?Leu?Gly?Met?Pro?Pro?Met

2165????????????????2170????????????????2175Val?Met?Ser?Arg?Phe?Pro?Phe?Met?Gly?Gln?Val?Val?Thr?Gly?Thr?Gln

2180????????????????2185????????????????2190Asn?Ser?Glu?Gly?Gln?Asn?Leu?Gly?Pro?Gln?Ala?Ile?Pro?Gln?Asp?Gly

2195????????????????2200????????????????2205Ser?Ile?Thr?His?Gln?Ile?Ser?Arg?Pro?Asn?Pro?Pro?Asn?Phe?Gly?Pro

2210????????????????2215????????????????2220Gly?Phe?Val?Asn?Asp?Ser?Gln?Arg?Lys?Gln?Tyr?Glu?Glu?Trp?Leu?Gln2225????????????????2230????????????????2235????????????????2240Glu?Thr?Gln?Gln?Leu?Leu?Gln?Met?Gln?Gln?Lys?Tyr?Leu?Glu?Glu?Gln

2245????????????????2250????????????????2255Ile?Gly?Ala?His?Arg?Lys?Ser?Lys?Lys?Ala?Leu?Ser?Ala?Lys?Gln?Arg

2260????????????????2265????????????????2270Thr?Ala?Lys?Lys?Ala?Gly?Arg?Glu?Phe?Pro?Glu?Glu?Asp?Ala?Glu?Gln

2275????????????????2280????????????????2285Leu?Lys?His?Val?Thr?Glu?Gln?Gln?Ser?Met?Val?Gln?Lys?Gln?Leu?Glu

2290????????????????2295????????????????2300Gln?Ile?Arg?Lys?Gln?Gln?Lys?Glu?His?Ala?Glu?Leu?Ile?Glu?Asp?Tyr2305????????????????2310????????????????2315????????????????2320Arg?Ile?Lys?Gln?Gln?Gln?Gln?Cys?Ala?Met?Ala?Pro?Pro?Thr?Met?Met

2325????????????????2330????????????????2335Pro?Ser?Val?Gln?Pro?Gln?Pro?Pro?Leu?Ile?Pro?Gly?Ala?Thr?Pro?Pro

2340????????????????2345????????????????2350Thr?Met?Ser?Gln?Pro?Thr?Phe?Pro?Met?Val?Pro?Gln?Gln?Leu?Gln?His

2355????????????????2360????????????????2365Gln?Gln?His?Thr?Thr?Val?Ile?Ser?Gly?His?Thr?Ser?Pro?Val?Arg?Met

2370????????????????2375????????????????2380Pro?Ser?Leu?Pro?Gly?Trp?Gln?Pro?Asn?Ser?Ala?Pro?Ala?His?Leu?Pro2385????????????????2390????????????????2395????????????????2400Leu?Asn?Pro?Pro?Arg?Ile?Gln?Pro?Pro?Ile?Ala?Gln?Leu?Pro?Ile?Lys

2405????????????????2410????????????????2415Thr?Cys?Thr?Pro?Ala?Pro?Gly?Thr?Val?Ser?Asn?Ala?Asn?Pro?Gln?Ser

2420????????????????2425????????????????2430Gly?Pro?Pro?Pro?Arg?Val?Glu?Phe?Asp?Asp?Asn?Asn?Pro?Phe?Ser?Glu

2435????????????????2440????????????????2445Ser?Phe?Gln?Glu?Arg?Glu?Arg?Lys?Glu?Arg?Leu?Arg?Glu?Gln?Gln?Glu

2450????????????????2455????????????????2460Arg?Gln?Arg?Ile?Gln?Leu?Met?Gln?Glu?Val?Asp?Arg?Gln?Arg?Ala?Leu2465????????????????2470????????????????2475????????????????2480Gln?Gln?Arg?Met?Glu?Met?Glu?Gln?His?Gly?Met?Val?Gly?Ser?Glu?Ile

2485????????????????2490????????????????2495Ser?Ser?Ser?Arg?Thr?Ser?Val?Ser?Gln?Ile?Pro?Phe?Tyr?Ser?Ser?Asp

2500????????????????2505????????????????2510Leu?Pro?Cys?Asp?Phe?Met?Gln?Pro?Leu?Gly?Pro?Leu?Gln?Gln?Ser?Pro

2515????????????????2520????????????????2525Gln?His?Gln?Gln?Gln?Met?Gly?Gln?Val?Leu?Gln?Gln?Gln?Asn?Ile?Gln

2530????????????????2535????????????????2540Gln?Gly?Ser?Ile?Asn?Ser?Pro?Ser?Thr?Gln?Thr?Phe?Met?Gln?Thr?Asn2545????????????????2550????????????????2555????????????????2560Glu?Arg?Arg?Gln?Val?Gly?Pro?Pro?Ser?Phe?Val?Pro?Asp?Ser?Pro?Ser

2565????????????????2570????????????????2575Ile?Pro?Val?Gly?Ser?Pro?Asn?Phe?Ser?Ser?Val?Lys?Gln?Gly?His?Gly

2580????????????????2585????????????????2590Asn?Leu?Ser?Gly?Thr?Ser?Phe?Gln?Gln?Ser?Pro?Val?Arg?Pro?Ser?Phe

2595????????????????2600????????????????2605Thr?Pro?Ala?Leu?Pro?Ala?Ala?Pro?Pro?Val?Ala?Asn?Ser?Ser?Leu?Pro

2610????????????????2615????????????????2620Cys?Gly?Gln?Asp?Ser?Thr?Ile?Thr?His?Gly?His?Ser?Tyr?Pro?Gly?Ser2625????????????????2630????????????????2635????????????????2640Thr?Gln?Ser?Leu?Ile?Gln?Leu?Tyr?Ser?Asp?Ile?Ile?Pro?Glu?Glu?Lys

2645????????????????2650????????????????2655Gly?Lys?Lys?Lys?Arg?Thr?Arg?Lys?Lys?Lys?Arg?Asp?Asp?Asp?Ala?Glu

2660????????????????2665????????????????2670Ser?Thr?Lys?Ala?Pro?Ser?Thr?Pro?His?Ser?Asp?Ile?Thr?Ala?Pro?Pro

2675????????????????2680????????????????2685Thr?Pro?Gly?Ile?Ser?Glu?Thr?Thr?Ser?Thr?Pro?Ala?Val?Ser?Thr?Pro

2690????????????????2695????????????????2700Ser?Glu?Leu?Pro?Gln?Gln?Ala?Asp?Gln?Glu?Ser?Val?Glu?Pro?Val?Gly2705????????????????2710????????????????2715????????????????2720Pro?Ser?Thr?Pro?Asn?Met?Ala?Ala?Gly?Gln?Leu?Cys?Thr?Glu?Leu?Glu

2725????????????????2730????????????????2735Asn?Lys?Leu?Pro?Asn?Ser?Asp?Phe?Ser?Gln?Ala?Thr?Pro?Asn?Gln?Gln

2740????????????????2745????????????????2750Thr?Tyr?Ala?Asn?Ser?Glu?Val?Asp?Lys?Leu?Ser?Met?Glu?Thr?Pro?Ala

2755????????????????2760????????????????2765Lys?Thr?Glu?Glu?Ile?Lys?Leu?Glu?Lys?Ala?Glu?Thr?Glu?Ser?Cys?Pro

2770????????????????2775????????????????2780Gly?Gln?Glu?Glu?Pro?Lys?Leu?Glu?Glu?Gln?Asn?Gly?Ser?Lys?Val?Glu2785????????????????2790????????????????2795????????????????2800Gly?Asn?Ala?Val?Ala?Cys?Pro?Val?Ser?Ser?Ala?Gln?Ser?Pro?Pro?His

2805????????????????2810????????????????2815Ser?Ala?Gly?Ala?Pro?Ala?Ala?Lys?Gly?Asp?Ser?Gly?Asn?Glu?Leu?Leu

2820????????????????2825????????????????2830Lys?His?Leu?Leu?Lys?Asn?Lys?Lys?Ser?Ser?Ser?Leu?Leu?Asn?Gln?Lys

2835????????????????2840????????????????2845Pro?Glu?Gly?Ser?Ile?Cys?Ser?Glu?Asp?Asp?Cys?Thr?Lys?Asp?Asn?Lys

2850????????????????2855????????????????2860Leu?Val?Glu?Lys?Gln?Asn?Pro?Ala?Glu?Gly?Leu?Gln?Thr?Leu?Gly?Ala2865????????????????2870????????????????2875????????????????2880Gln?Met?Gln?Gly?Gly?Phe?Gly?Cys?Gly?Asn?Gln?Leu?Pro?Lys?Thr?Asp

2885????????????????2890????????????????2895Gly?Gly?Ser?Glu?Thr?Lys?Lys?Gln?Arg?Ser?Lys?Arg?Thr?Gln?Arg?Thr

2900????????????????2905????????????????2910Gly?Glu?Lys?Ala?Ala?Pro?Arg?Ser?Lys?Lys?Arg?Lys?Lys?Asp?Glu?Glu

2915????????????????2920????????????????2925Glu?Lys?Gln?Ala?Met?Tyr?Ser?Ser?Thr?Asp?Thr?Phe?Thr?His?Leu?Lys

2930????????????????2935????????????????2940Gln?Val?Arg?Gln?Leu?Ser?Leu?Leu?Pro?Leu?Met?Glu?Pro?Ile?Ile?Gly2945????????????????2950????????????????2955????????????????2960Val?Asn?Phe?Ala?His?Phe?Leu?Pro?Tyr?Gly?Ser?Gly?Gln?Phe?Asn?Ser

2965????????????????2970????????????????2975Gly?Asn?Arg?Leu?Leu?Gly?Thr?Phe?Gly?Ser?Ala?Thr?Leu?Glu?Gly?Val

2980????????????????2985????????????????2990Ser?Asp?Tyr?Tyr?Ser?Gln?Leu?Ile?Tyr?Lys?Gln?Asn?Asn?Leu?Ser?Asn

2995????????????????3000????????????????3005Pro?Pro?Thr?Pro?Pro?Ala?Ser?Leu?Pro?Pro?Thr?Pro?Pro?Pro?Met?Ala

3010????????????????3015????????????????3020Cys?Gln?Lys?Met?Ala?Asn?Gly?Phe?Ala?Thr?Thr?Glu?Glu?Leu?Ala?Gly3025????????????????3030????????????????3035????????????????3040Lys?Ala?Gly?Val?Leu?Val?Ser?His?Glu?Val?Thr?Lys?Thr?Leu?Gly?Pro

3045????????????????3050????????????????3055Lys?Pro?Phe?Gln?Leu?Pro?Phe?Arg?Pro?Gln?Asp?Asp?Leu?Leu?Ala?Arg

3060????????????????3065????????????????3070Ala?Leu?Ala?Gln?Gly?Pro?Lys?Thr?Val?Asp?Val?Pro?Ala?Ser?Leu?Pro

3075????????????????3080????????????????3085Thr?Pro?Pro?His?Asn?Asn?Gln?Glu?Glu?Leu?Arg?Ile?Gln?Asp?His?Cys

3090????????????????3095????????????????3100Gly?Asp?Arg?Asp?Thr?Pro?Asp?Ser?Phe?Val?Pro?Ser?Ser?Ser?Pro?Glu3105????????????????3110????????????????3115????????????????3120Ser?Val?Val?Gly?Val?Glu?Val?Ser?Arg?Tyr?Pro?Asp?Leu?Ser?Leu?Val

3125????????????????3130????????????????3135Lys?Glu?Glu?Pro?Pro?Glu?Pro?Val?Pro?Ser?Pro?Ile?Ile?Pro?Ile?Leu

3140????????????????3145????????????????3150Pro?Ser?Thr?Ala?Gly?Lys?Ser?Ser?Glu?Ser?Arg?Arg?Asn?Asp?Ile?Lys

3155????????????????3160????????????????3165Thr?Glu?Pro?Gly?Thr?Leu?Tyr?Phe?Ala?Ser?Pro?Phe?Gly?Pro?Ser?Pro

3170????????????????3175????????????????3180Asn?Gly?Pro?Arg?Ser?Gly?Leu?Ile?Ser?Val?Ala?Ile?Thr?Leu?His?Pro3185????????????????3190????????????????3195????????????????3200Thr?Ala?Ala?Glu?Asn?Ile?Ser?Ser?Val?Val?Ala?Ala?Phe?Ser?Asp?Leu

3205????????????????3210????????????????3215Leu?His?Val?Arg?Ile?Pro?Asn?Ser?Tyr?Glu?Val?Ser?Ser?Ala?Pro?Asp

3220????????????????3225????????????????3230Val?Pro?Ser?Met?Gly?Leu?Val?Ser?Ser?His?Arg?Ile?Asn?Pro?Gly?Leu

3235????????????????3240????????????????3245Glu?Tyr?Arg?Gln?His?Leu?Leu?Leu?Arg?Gly?Pro?Pro?Pro?Gly?Ser?Ala

3250????????????????3255????????????????3260Asn?Pro?Pro?Arg?Leu?Val?Ser?Ser?Tyr?Arg?Leu?Lys?Gln?Pro?Asn?Val3265????????????????3270????????????????3275????????????????3280Pro?Phe?Pro?Pro?Thr?Ser?Asn?Gly?Leu?Ser?Gly?Tyr?Lys?Asp?Ser?Ser

3285????????????????3290????????????????3295His?Gly?Ile?Ala?Glu?Ser?Ala?Ala?Leu?Arg?Pro?Gln?Trp?Cys?Cys?His

3300????????????????3305????????????????3310Cys?Lys?Val?Val?Ile?Leu?Gly?Ser?Gly?Val?Arg?Lys?Ser?Phe?Lys?Asp

3315????????????????3320????????????????3325Leu?Thr?Leu?Leu?Asn?Lys?Asp?Ser?Arg?Glu?Ser?Thr?Lys?Arg?Val?Glu

3330????????????????3335????????????????3340Lys?Asp?Ile?Val?Phe?Cys?Ser?Asn?Asn?Cys?Phe?Ile?Leu?Tyr?Ser?Ser3345????????????????3350????????????????3355????????????????3360Thr?Ala?Gln?Ala?Lys?Asn?Ser?Glu?Asn?Lys?Glu?Ser?Ile?Pro?Ser?Leu

3365????????????????3370????????????????3375Pro?Gln?Ser?Pro?Met?Arg?Glu?Thr?Pro?Ser?Lys?Ala?Phe?His?Gln?Tyr

3380????????????????3385????????????????3390Ser?Asn?Asn?Ile?Ser?Thr?Leu?Asp?Val?His?Cys?Leu?Pro?Gln?Leu?Pro

3395????????????????3400????????????????3405Glu?Lys?Ala?Ser?Pro?Pro?Ala?Ser?Pro?Pro?Ile?Ala?Phe?Pro?Pro?Ala

3410????????????????3415????????????????3420Phe?Glu?Ala?Ala?Gln?Val?Glu?Ala?Lys?Pro?Asp?Glu?Leu?Lys?Val?Thr3425????????????????3430????????????????3435????????????????3440Val?Lys?Leu?Lys?Pro?Arg?Leu?Arg?Ala?Val?His?Gly?Gly?Phe?Glu?Asp

3445????????????????3450????????????????3455Cys?Arg?Pro?Leu?Asn?Lys?Lys?Trp?Arg?Gly?Met?Lys?Trp?Lys?Lys?Trp

3460????????????????3465????????????????3470Ser?Ile?His?Ile?Val?Ile?Pro?Lys?Gly?Thr?Phe?Lys?Pro?Pro?Cys?Glu

3475????????????????3480????????????????3485Asp?Glu?Ile?Asp?Glu?Phe?Leu?Lys?Lys?Leu?Gly?Thr?Ser?Leu?Lys?Pro

3490????????????????3495????????????????3500Asp?Pro?Val?Pro?Lys?Asp?Tyr?Arg?Lys?Cys?Cys?Phe?Cys?His?Glu?Glu3505????????????????3510????????????????3515????????????????3520Gly?Asp?Gly?Leu?Thr?Asp?Gly?Pro?Ala?Arg?Leu?Leu?Asn?Leu?Asp?Leu

3525????????????????3530????????????????3535Asp?Leu?Trp?Val?His?Leu?Asn?Cys?Ala?Leu?Trp?Ser?Thr?Glu?Val?Tyr

3540????????????????3545????????????????3550Glu?Thr?Gln?Ala?Gly?Ala?Leu?Ile?Asn?Val?Glu?Leu?Ala?Leu?Arg?Arg

3555????????????????3560????????????????3565Gly?Leu?Gln?Met?Lys?Cys?Val?Phe?Cys?His?Lys?Thr?Gly?Ala?Thr?Ser

3570????????????????3575????????????????3580Gly?Cys?His?Arg?Phe?Arg?Cys?Thr?Asn?Ile?Tyr?His?Phe?Thr?Cys?Ala3585????????????????3590????????????????3595????????????????3600Ile?Lys?Ala?Gln?Cys?Met?Phe?Phe?Lys?Asp?Lys?Thr?Met?Leu?Cys?Pro

3605????????????????3610????????????????3615Met?His?Lys?Pro?Lys?Gly?Ile?His?Glu?Gln?Glu?Leu?Ser?Tyr?Phe?Ala

3620????????????????3625????????????????3630Val?Phe?Arg?Arg?Val?Tyr?Val?Gln?Arg?Asp?Glu?Val?Arg?Gln?Ile?Ala

3635????????????????3640????????????????3645Ser?Ile?Val?Gln?Arg?Gly?Glu?Arg?Asp?His?Thr?Phe?Arg?Val?Gly?Ser

3650????????????????3655????????????????3660Leu?Ile?Phe?His?Thr?Ile?Gly?Gln?Leu?Leu?Pro?Gln?Gln?Met?Gln?Ala3665????????????????3670????????????????3675????????????????3680Phe?His?Ser?Pro?Lys?Ala?Leu?Phe?Pro?Val?Gly?Tyr?Glu?Ala?Ser?Arg

3685????????????????3690????????????????3695Leu?Tyr?Trp?Ser?Thr?Arg?Tyr?Ala?Asn?Arg?Arg?Cys?Arg?Tyr?Leu?Cys

3700????????????????3705????????????????3710Ser?Ile?Glu?Glu?Lys?Asp?Gly?Arg?Pro?Val?Phe?Val?Ile?Arg?Ile?Val

3715????????????????3720????????????????3725Glu?Gln?Gly?His?Glu?Asp?Leu?Val?Leu?Ser?Asp?Ile?Ser?Pro?Lys?Gly

3730????????????????3735????????????????3740Val?Trp?Asp?Lys?Ile?Leu?Glu?Pro?Val?Ala?Cys?Val?Arg?Lys?Lys?Ser3745????????????????3750????????????????3755????????????????3760Glu?Met?Leu?Gln?Leu?Phe?Pro?Ala?Tyr?Leu?Lys?Gly?Glu?Asp?Leu?Phe

3765????????????????3770????????????????3775Gly?Leu?Thr?Val?Ser?Ala?Val?Ala?Arg?Ile?Ala?Glu?Ser?Leu?Pro?Gly

3780????????????????3785????????????????3790Val?Glu?Ala?Cys?Glu?Asn?Tyr?Thr?Phe?Arg?Tyr?Gly?Arg?Asn?Pro?Leu

3795????????????????3800????????????????3805Met?Glu?Leu?Pro?Leu?Ala?Val?Asn?Pro?Thr?Gly?Cys?Ala?Arg?Ser?Glu

3810????????????????3815????????????????3820Pro?Lys?Met?Ser?Ala?His?Val?Lys?Arg?Pro?His?Thr?Leu?Asn?Ser?Thr3825????????????????3830????????????????3835????????????????3840Ser?Thr?Ser?Lys?Ser?Phe?Gln?Ser?Thr?Val?Thr?Gly?Glu?Leu?Asn?Ala

3845????????????????3850????????????????3855Pro?Tyr?Ser?Lys?Gln?Phe?Val?His?Ser?Lys?Ser?Ser?Gln?Tyr?Arg?Lys

3860????????????????3865????????????????3870Met?Lys?Thr?Glu?Trp?Lys?Ser?Asn?Val?Tyr?Leu?Ala?Arg?Ser?Arg?Ile

3875????????????????3880????????????????3885Gln?Gly?Leu?Gly?Leu?Tyr?Ala?Ala?Arg?Asp?Ile?Glu?Lys?His?Thr?Met

3890????????????????3895????????????????3900Val?Ile?Glu?Tyr?Ile?Gly?Thr?Ile?Ile?Arg?Asn?Glu?Val?Ala?Asn?Arg3905????????????????3910????????????????3915????????????????3920Lys?Glu?Lys?Leu?Tyr?Glu?Ser?Gln?Asn?Arg?Gly?Val?Tyr?Met?Phe?Arg

3925????????????????3930????????????????3935Met?Asp?Asn?Asp?His?Val?Ile?Asp?Ala?Thr?Leu?Thr?Gly?Gly?Pro?Ala

3940????????????????3945????????????????3950Arg?Tyr?Ile?Asn?His?Ser?Cys?Ala?Pro?Asn?Cys?Val?Ala?Glu?Val?Val

3955????????????????3960????????????????3965Thr?Phe?Glu?Arg?Gly?His?Lys?Ile?Ile?Ile?Ser?Ser?Ser?Arg?Arg?Ile

3970????????????????3975????????????????3980Gln?Lys?Gly?Glu?Glu?Leu?Cys?Tyr?Asp?Tyr?Lys?Phe?Asp?Phe?Glu?Asp3985????????????????3990????????????????3995????????????????4000Asp?Gln?His?Lys?Ile?Pro?Cys?His?Cys?Gly?Ala?Val?Asn?Cys?Arg?Lys

4,005 4010 4015Trp Met Asn＜210〉426＜211〉174＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉426Pro Val Lys Asp Arg Glu Ala Phe Gln Arg Leu Asn Phe Leu Tyr Gln

5??????????????????10??????????????????15Val?Ser?Leu?Arg?Gln?Gly?Pro?His?Gly?Asp?Gly?Ala?Arg?Arg?Pro?Arg

20??????????????????25??????????????????30Val?Thr?Ala?Pro?Leu?Pro?Gln?Ala?Ala?His?Cys?Val?Leu?Ala?Gln?Asp

35??????????????????40??????????????????45Pro?Glu?Asn?Gln?Ala?Leu?Ala?Arg?Phe?Tyr?Cys?Tyr?Thr?Glu?Arg?Thr

50??????????????????55??????????????????60Ile?Ala?Lys?Arg?Leu?Val?Leu?Arg?Arg?Asp?Pro?Ser?Val?Lys?Arg?Thr?65??????????????????70??????????????????75??????????????????80Leu?Cys?Arg?Gly?Cys?Ser?Ser?Leu?Leu?Val?Pro?Gly?Leu?Thr?Cys?Thr

85??????????????????90??????????????????95His?Arg?Gln?Arg?Arg?Cys?Arg?Gly?Gln?Arg?Trp?Thr?Val?Gln?Thr?Cys

100?????????????????105?????????????????110Leu?Thr?Cys?Gln?Arg?Ser?Gln?Arg?Phe?Leu?Asn?Asp?Pro?Gly?His?Leu

115?????????????????120?????????????????125Leu?Trp?Gly?Asp?Arg?Pro?Glu?Ala?Gln?Leu?Gly?Ser?Gln?Ala?Asp?Ser

130?????????????????135?????????????????140Lys?Pro?Leu?Gln?Pro?Leu?Pro?Asn?Thr?Ala?His?Ser?Ile?Ser?Asp?Arg145?????????????????150?????????????????155?????????????????160Leu?Pro?Glu?Glu?Lys?Met?Gln?Thr?Gln?Gly?Ser?Ser?Asn?Gln

165 170＜210〉427＜211〉184＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉427Cys Glu Thr Ala Lys Met Val Val Gly Ala Phe Pro Met Ala Lys Leu

5??????????????????10??????????????????15Leu?Tyr?Leu?Gly?Ile?Arg?Gln?Val?Ser?Lys?Pro?Leu?Ala?Asn?Arg?Ile

20??????????????????25??????????????????30Lys?Glu?Ala?Ala?Arg?Arg?Ser?Glu?Phe?Phe?Lys?Thr?Tyr?Ile?Cys?Leu

35??????????????????40??????????????????45Pro?Pro?Ala?Gln?Leu?Tyr?His?Trp?Val?Glu?Met?Arg?Thr?Lys?Met?Arg

50??????????????????55??????????????????60Ile?Met?Gly?Phe?Arg?Gly?Thr?Val?Ile?Lys?Pro?Leu?Asn?Glu?Glu?Ala?65??????????????????70??????????????????75??????????????????80Ala?Ala?Glu?Leu?Gly?Ala?Glu?Leu?Leu?Gly?Glu?Ala?Thr?Ile?Phe?Ile

85??????????????????90??????????????????95Val?Gly?Gly?Gly?Cys?Leu?Val?Leu?Glu?Tyr?Trp?Arg?His?Gln?Ala?Gln

100?????????????????105?????????????????110Gln?Arg?His?Lys?Glu?Glu?Glu?Gln?Arg?Ala?Ala?Trp?Asn?Ala?Leu?Arg

115?????????????????120?????????????????125Asp?Glu?Val?Gly?His?Leu?Ala?Leu?Ala?Leu?Glu?Ala?Leu?Gln?Ala?Gln

130?????????????????135?????????????????140Val?Gln?Ala?Ala?Pro?Pro?Gln?Gly?Ala?Leu?Glu?Glu?Leu?Arg?Thr?Glu145?????????????????150?????????????????155?????????????????160Leu?Gln?Glu?Val?Arg?Ala?Gln?Leu?Cys?Asn?Pro?Gly?Arg?Ser?Ala?Ser

165?????????????????170?????????????????175His?Ala?Val?Pro?Ala?Ser?Lys?Lys

180 <210> 428 <211> 6476 <212> DNA <213> Homo (Homo sapiens) <400> 428 cactgactgg actgaaaaca gggccaagaa aactgctgct gcagggggtc ctgaaaacag 60 ctggaacccg gcagtgatgt gggacctaac ttgaagttaa cctgtggtgg tgaggttgga 120 accagttgga ttatgattta ttttctacac tcttgtacgg aatgcagagc tgttgtatcc 180 tgatgaatct actgctaaat atagtcattt ggaataattt taagtattga tcttaaaact 240 tgtaccacaa caagagtgtc taaaaagcac ggcaagctca ttacgttctt acgaacattc 300 atgaagtctc gtccaacaaa acagaagctg aagcagcggg gaatcttgaa agagagggtg 360 tttggttgtg acctggggga gcaccttcta aattctggtt ttgaagtgcc gcagttcttc 420 aaagctgcac agcattcatt gagagatatg gcatcgtgga tggaatctat cgcctttctg 480 gtgttgcctc caatatccag agactacgcc atgaatttga ctctgagcac gtccccgacc 540 tgacgaaaga accgtatgtt caggacatcc attctgtggg ttccctatgt aagctgtact 600 tccgggaact cccaaaccct ctgcttacct accagctgta tgagaaattt tctgatgcag 660 tttcagcagc aacagatgaa gaaaggctga taaaaatcca cgatgtcatc cagcagctcc 720 ccccaccaca ctacagaaca ctggagttcc tgatgagaca cttgtctctt ctagctgact 780 attgttccat cacaaatatg catgcaaaaa atctagcaat tgtttgggct ccaaacctgt 840 taagatcaaa acagatagaa tctgcctgct tcagtggaac agcagctttc atggaagtga 900 ggattcagtc tgtggttgtt gagttcatcc tgaatcacgt tgatgtgctg ttcagcggca 960 gaatcagcat ggccatgcaa gagggggcag cttctctatc aaggcccaag tccctcctgg 1020 tatcctctcc atccaccaaa ctgctgacat tggaagaggc ccaggcacga acacaagctc 1080 aggtcaattc tccaattgtg acggaaaata aatatatcga agtaggagaa ggacctgctg 1140 cacttcaggg gaaatttcat accataattg agttcccact tgaaagaaag aggcctcaaa 1200 ataagatgaa aaagtctcct gtgggtagct ggcgttcctt tttcaacttg gggaaatcat 1260 catctgtttc taaacgaaag ctgcagcgga atgagagtga gccttcagag atgaaagcca 1320 tggctctgaa aggtggcagg gcagaaggaa ccctccgttc agctaaaagt gaggagtctc 1380 ttacatctct ccatgcagtt gatggtgatt ctaagctctt ccgacccaga agacccagat 1440 cttccagtga tgcactgtct gcctctttta atggagaaat gctggggaac cgctgtaact 1500 cctatgataa tctgcctcat gacaatgaga gtgaggagga aggagggctg cttcatatcc 1560 cagcccttat gtctcctcat tcagctgagg atgttgactt gagcccacca gacattggag 1620 tagccagcct ggattttgat ccaatgtcat ttcaatgtag tcctcctaag gccgaatcag 1680 aatgtctgga gagtggtgct tcctttttag attcaccagg atactccaag gataaaccaa 1740 gtgccaataa aaaggatgca gaaacaggta gtagccaatg tcagactcca ggaagcacag 1800 caagctctga acctgtctct cctcttcagg agaaactgag tccattcttt accctggact 1860 tgagcccaac tgaagataaa tcatctaagc catcctcctt tactgaaaag gtcgtctatg 1920 ctttctctcc gaagatagga cggaaattaa gcaaatcacc ttctatgagc atatctgagc 1980 caatttcagt gaccctacca ccacgggtgt cagaagtcat tggtacagtc tcaaatacca 2040 cagctcagaa tgcatcatct tcaacctggg acaaatgcgt tgaagaaagg gatgccacaa 2100 atagatcccc cacccagata gtaaagatga aaacaaatga gacagttgcc caagaagcat 2160 atgaatctga agtccagccc ctggaccagg tggctgctga agaagtagaa ttgccaggga 2220 aagaggatca gtctgtctca agcagtcaga gtaaggctgt agcttctgga cagactcaga 2280 caggagcagt tacccatgac ccccctcagg attccgttcc tgtcagttca gtctctctta 2340 tcccaccacc accgcctccg aaaaatgttg cccgaatgtt ggcgctagca ttagctgagt 2400 ccgcacagca agcctcaact cagtcattga agagaccagg gacctctcag gctgggtata 2460 caaattatgg agacatagcg gtggctacaa ctgaagataa tctgtccagt tcttactctg 2520 cagttgctct agataaggcc tatttccaaa ccgatcgacc agcagagcag ttccacctcc 2580 agaataatgc accaggaaac tgtgaccatc ctctaccaga gacaacagct actggggatc 2640 ctacccattc caacacaact gaatctgggg agcaacatca ccaagtagac ttaacaggga 2700 atcagccaca tcaagcatat ttatctgggg acccagaaaa ggccagaatt acttcagttc 2760 ccttagactc agagaagtct gatgatcatg taagtttccc tgaagaccag tctgggaaga 2820 acagtatgcc aactgtctcc ttcttggatc aggaccagtc tccaccccgt ttctacagtg 2880 gagatcagcc tccttcttat cttggtgcaa gtgtggataa actccatcac cctttagaat 2940 ttgcagacaa atctcccaca cctcctaatt tacctagcga taaaatctac cctccttctg 3000 ggtcccccga agagaatacc agcacagcca ccatgactta catgacaact actccagcaa 3060 cagcccaaat gagcaccaag gaagccagct gggatgtggc tgaacaaccc accactgctg 3120 attttgctgc tgccacactt cagcgcacgc acagaactaa tcgtcccctt ccccctccgc 3180 cttcccagag atctgcagag cagccaccag ttgtggggca ggtacaagca gcaaccaata 3240 taggattaaa taattcccac aaggttcaag gagtagttcc agttccagag aggccacctg 3300 aacctcgagc catggatgac cctgcgtctg ccttcatcag tgacagtggt gctgctgctg 3360 ctcagtgtcc catggctaca gctgtccagc caggcctgcc tgagaaagtg cgggacggtg 3420 cccgggtccc gctgctgcac ctgcgcgccg agtctgtccc tgcgcatccc tgtggctttc 3480 ctgcaccact gccccccacc aggatgatgg agagtaagat gattgctgcc atacactcca 3540 gcagtgcaga tgccaccagc agttcaaatt atcattcctt tgtcactgct tcatccacct 3600 ctgtggacga tgcattgcct ttaccacttc ctgtcccaca acctaagcat gcttctcaga 3660 aaacagttta ctcctccttt gctaggcccg atgtcaccac tgaacccttt ggtccagata 3720 actgtttgca tttcaatatg actccaaact gccagtaccg tccccagagt gtacctcccc 3780 atcacaataa attggagcag caccaagtgt atggtgccag gtcagagcca ccagcctcca 3840 tgggtcttcg ttataacaca tatgtggccc caggaagaaa cgcatctgga caccactcca 3900 agccatgcag ccgggtcgag tatgtgtctt ctttgagctc ctctgtcagg aatacctgtt 3960 accccgaaga cattccaccg taccctacca tccggagagt gcagtctctc catgctccgc 4020 cgtcttccat gattcgctct gttcccattt cacggacaga agttccccca gatgatgagc 4080 cagcctactg cccaagacct ctgtaccaat ataagccata tcagtcctcc caggcccgct 4l40 cagattatca tgtcactcag cttcagcctt actttgagaa tggccgggtc cactacaggt 4200 atagcccata ttccagttct tctagttcct attacagtcc agatggggcc ctgtgtgatg 4260 tggatgccta tggcacagtc cagttgagac cccttcaccg ccttcccaat cgagactttg 4320 ctttctacaa tcctaggctg caaggaaaga gcttgtacag ttatgctggt ttggctccac 4380 gtccccgggc caacgtgact ggctatttct ctcccaacga ccataatgta gtcagcatgc 4440 ctccggctgc tgatgtgaag cacacctaca cctcatggga tcttgaggac atggaaaaat 4500 accgcatgca gtccatccgg agagagagcc gtgctcggca gaaggtgaaa gggcctgtca 4560 tgtcccaata tgataacatg accccggcgg tgcaggacga cttgggtggg atctatgtca 4620 tccatctgcg tagtaaatca gatcctggga aaactggact tctctcagtg gcagaaggaa 4680 aggagagccg ccatgcagcc aaggccatca gtcccgaggg agaggaccgc ttctatagga 4740 ggcatcccga ggcagagatg gacagagccc accatcacgg aggccatggt agcacgcagc 4800 cggagaagcc atccctgcct cagaagcaga gcagcctgag gagcaggaag cttcctgaca 4860 tgggctgcag tcttcctgag cacagggcac accaagaagc aagccatagg cagttctgtg 4920 agtcaaagaa tgggccccct tatccccagg gagctggcca gttagattat gggtccaaag 4980 ggattccaga cacttctgag ccagtcagct accacaactc tggagtaaaa tatgctgcat 5040 ccgggcaaga atctttaaga ctgaaccaca aagaggtaag gctctccaaa gagatggagc 5100 gaccctgggt taggcagcct tctgccccag agaaacactc cagagactgc tacaaggagg 5160 aagaacacct cactcagtca atcgtcccac cccctaaacc agagaggagt catagcctca 5220 aactccatca tacccagaac gtggagaggg accccagtgt gctgtaccag taccaaccac 5280 acggcaagcg ccagagcagt gtgactgttg tgtcccagta tgataacctg gaagattacc 5340 actccctgcc tcagcaccag cgaggagtct ttggaggggg cggcatgggg acgtatgtgc 5400 cccctggctt tccccatcca cagagcagga cctatgctac agcgttgggt caaggggcct 5460 tcctgcccgc agagttgtcc ttgcagcatc ctgaaacaca gatccatgca gaatgagccc 5520 tgcgagcaat agagttgaag cagcctctgc tggacagtgg actgttctat ttttttcaat 5580 aaccaaaaag attaaacaaa aaatactata aaacccctga ccacatttaa aaaatgataa 5640 taaaagtaaa caaatcagca tctttttccc cttccctgct tcattacccc ctcttccatc 5700 tatagacttt gtcatttttg tctttagaaa agatctgaag gatggtaaag ccccgtgctg 5760 aaacccagta gagaaacctg tctcaggaca cacttgccat ctagggctag cttgaaagag 5820 cctgaggact gcctttaact gaatttgaat tcagcattgt cctttcttct tagtatttgc 5880 tgcataattg agagcagttc acatcgattt cctggtaggc gtctgcattc cctgttgtgt 5940 tcctgcttct ccttcagtag ctgcacaact tgcgcagatc gacacactgt tgtcacttca 6000 ttctccccgt ctgagaagga tcttgtgttc agttagagtc gtggaaaaat ccctgatcct 6060 tcaaggtcag tcagacagtt ggcaacatta taattaaaaa taagaaatta agactttaaa 6120 ttaaacattt ggtagagtca tcataaaaca ccagaccact tagactcagg ctgaaccata 6180 ctctttctat tcttattttt catccttgtt cctcacggtt cagtgaacag gctcatatca 6240 tgacagaatg gacttttaaa agttagtact taaggaaact tctttaggtg gaagaaagta 6300 aagttcttat tgtcagtgaa ctttattagc accagaaatc tctattgatg cttttaatgc 6360 attgcctgcc ttcaggtttt cttcttaccc cacccctcaa taagatttgg tgaattgtaa 6420 ttctagtaaa acatgtcata ccattggttt tcctaaatta tcaactttct ttcatt 6476 <210> 429 <211> 732 <212> DNA <213> Homo (Homo sapiens) <400> 429 tgggatttgg tctctttgac taatcaccaa aaagcaacca actcctccga ctcttccttg 60 gcttcaacct tagctggggc tgcagcagca gagcgagcag ctgtggtggc agcagcaacg 120 gggcagcagc acaaaggcag atggatcagc caagaaggcc ttgacctttt cagcaagtgg 180 gaaggtgtaa tccgtctcca cagacaaggc caggaccggc gtcaaaggtg aagcaggaca 240 tgcctccgcc ggggggctat gggcccatcg actacaaacg gaacttgccg cgtcgaggac 300 tgtcgggcta cagcatgctg gccataggga ttggaaccct gatctacggg cactggagca 360 taatgaagtg gaaccgtgag cgcaggcgcc tacaaatcga ggacttcgag gctcgcatcg 420 cgctgttgcc actgttacag gcagaaaccg accggaggac cttgcagatg cttcgggaga 480 acctggagga ggaggccatc atcatgaagg acgtgcccga ctggaaggtg ggggagtctg 540 tgttccacac aacccgctgg gtgcccccct tgatcgggga gctgtacggg ctgcgcacca 600 cagaggaggc tctccatgcc agccacggct tcatgtggta cacgtaggcc ctgtgccctc 660 cggccacctg gatccctgcc cctccccact gggacggaat aaatgctctg cagacctgaa 720 aaaaaaaaaa aa 732 <210> 430 <211> 2843 <212> DNA <213> Homo (Homo sapiens) <400> 430 gcgggcccag gaggcggcgg cggcggcggc ggacgggccc cccgcggcag acggcgagga 60 cggacaggac ccgcacagca agcacctgta cacggccgac atgttcacgc acgggatcca 120 gagcgccgcg cacttcgtca tgttcttcgc gccctggtgt ggacactgcc agcggctgca 180 gccgacttgg aatgacctgg gagacaaata caacagcatg gaagatgcca aagtctatgt 240 ggctaaagtg gactgcacgg cccactccga cgtgtgctcc gcccaggggg tgcgaggata 300 ccccacctta aagcttttca agccaggcca agaagctgtg aagtaccagg gtcctcggga 360 cttccagaca ctggaaaact ggatgctgca gacactgaac gaggagccag tgacaccaga 420 gccggaagtg gaaccgccca gtgcccccga gctcaagcaa gggctgtatg agctctcagc 480 aagcaacttt gagctgcacg ttgcacaagg cgaccacttt atcaagttct tcgctccgtg 540 gtgtggtcac tgcaaagccc tggctccaac ctgggagcag ctggctctgg gccttgaaca 600 ttccgaaact gtcaagattg gcaaggttga ttgtacacag cactatgaac tctgctccgg 660 aaaccaggtt cgtggctatc ccactcttct ctggttccga gatgggaaaa aggtggatca 720 gtacaaggga aagcgggatt tggagtcact gagggagtac gtggagtcgc agctgcagcg 780 cacagagact ggagcgacgg agaccgtcac gccctcagag gccccggtgc tggcagctga 840 gcccgaggct gacaagggca ctgtgttggc actcactgaa aatactttcg atgacaccat 900 tgcagaagga ataaccttca tcaagtttta tgctccatgg tgtggtcatt gtaagactct 960 ggctcctact tgggaggaac tctctaaaaa ggaattccct ggtctggcgg gggtcaagat 1020 cgccgaagta gactgcactg ctgaacggaa tatctgcagc aagtattcgg tacgaggcta 1080 ccccacgtta ttgcttttcc gaggagggaa gaaagtcagt gagcacagtg gaggcagaga 1140 ccttgactcg ttacaccgct ttgtcctgag ccaagcgaaa gacgaacttt aggaacacag 1200 ttggaggtca cctctcctgc ccagctcccg caccctgcgt ttaggagttc agtcccacag 1260 aggccactgg gttcccagtg gtggctgttc agaaagcaga acatactaag cgtgaggtat 1320 cttctttgtg tgtgtgtttt ccaagccaac acactctaca gattctttat taagttaagt 1380 ttctctaagt aaatgtgtaa ctcatggtca ctgtgtaaac attttcagtg gcgatatatc 1440 ccctttgacc ttctcttgat gaaatttaca tggtttcctt tgagactaaa atagcgttga 1500 gggaaatgaa attgctggac tatttgtggc tcctgagttg agtgattttg gtgaaagaaa 1560 gcacatccaa agcatagttt acctgcccac gagttctgga aaggtggcct tgtggcagta 1620 ttgacgttcc tctgatctta aggtcacagt tgactcaata ctgtgttggt ccgtagcatg 1680 gagcagattg aaatgcaaaa acccacacct ctggaagata ccttcacggc cgctgctgga 1740 gcttctgttg ctgtgaatac ttctctcagt gtgagaggtt agccgtgatg aaagcagcgt 1800 tacttctgac cgtgcctgag taagagaatg ctgatgccat aactttatgt gtcgatactt 1860 gtcaaatcag ttactgttca ggggatcctt ctgtttctca cggggtgaaa catgtcttta 1920 gttcctcatg ttaacacgaa gccagagccc acatgaactg ttggatgtct tccttagaaa 1980 gggtaggcat ggaaaattcc acgaggctca ttctcagtat ctcattaact cattgaaaga 2040 ttccagttgt atttgtcacc tggggtgaca agaccagaca ggctttccca ggcctgggta 2100 tccagggagg ctctgcagcc ctgctgaagg gccctaacta gagttctaga gtttctgatt 2160 ctgtttctca gtagtccttt tagaggcttg ctatacttgg tctgcttcaa ggaggtcgac 2220 cttctaatgt atgaagaatg ggatgcattt gatctcaaga ccaaagacag atgtcagtgg 2280 gctgctctgg ccctggtgtg cacggctgtg gcagctgttg atgccagtgt cctctaactc 2340 atgctgtcct tgtgattaaa cacctctatc tcccttggga ataagcacat acaggcttaa 2400 gctctaagat agataggtgt ttgtcctttt accatcgagc tacttcccat aataaccact 2460 ttgcatccaa cactcttcac ccacctccca tacgcaaggg gatgtggata cttggcccaa 2520 agtaactggt ggtaggaatc ttagaaacaa gaccacttat actgtctgtc tgaggcagaa 2580 gataacagca gcatctcgac cagcctctgc cttaaaggaa atctttatta atcacgtatg 2640 gttcacagat aattcttttt ttaaaaaaac ccaacctcct agagaagcac aactgtcaag 2700 agtcttgtac acacaacttc agctttgcat cacgagtctt gtattccaag aaaatcaaag 2760 tggtacaatt tgtttgttta cactatgata ctttctaaat aaactctttt ttttaaaaaa 2820 aaaaaaaaaa aaaaaaactc gag 2843 <210> 431 <211> 640 <212> DNA <213> Homo (Homo sapiens) <400> 431 ggtaacgtta tagtatttgt cagaagttgg ggtctccgtg ggcattgtga tccgtcccag 60 gcagtggatt aggaggccag aaggagatcc cttccacggt gctaggctga gatggatcct 120 ctcagggccc aacagctggc tgcggagctg gaggtggaga tgatggccga tatgtacaac 180 agaatgacca gtgcctgcca ccggaagtgt gtgcctcctc actacaagga agcagagctc 240 tccaagggcg agtctgtgtg cctggaccga tgtgtctcta agtacctgga catccatgag 300 cggatgggca aaaagttgac agagttgtct atgcaggatg aagagctgat gaagagggtg 360 cagcagagct ctgggcctgc atgaggtccc tgtcagtata caccctgggg tgtaccccac 420 cccttcccac tttaataaac gtgctccctg ttgggtgtca tctgtgaaga ctgccaggcc 480 taggctctct gtagagagtc ttcaagatcc cggagtggta gcgctgtctc ctggtgaagg 540 agtatttgtc acactggaat gtgactgtgt gtgtatgtat gtgtatatat atatatatat 600 atatatataa acaagtttgt tgacacctac aaaaaaaaaa 640 <210> 432 <21l> 2068 <212> DNA <213> Homo (Homo sapiens) <400> 432 cctcagaagt ccgtgccagt gaccggaggc ggcggcggcg agcggttcct tgtgggctag 60 aagaatcctg caaaaatgtc tctctatcca tctctcgaag acttgaaggt agacaaagta 120 attcaggctc aaactgcttt ttctgcaaac cctgccaatc cagcaatttt gtcagaagct 180 tctgctccta tccctcacga tggaaatctc tatcccagac tgtatccaga gctctctcaa 240 tacatggggc tgagtttaaa tgaagaagaa atacgtgcaa atgtggccgt ggtttctggt 300 gcaccacttc aggggcagtt ggtagcaaga ccttccagta taaactatat ggtggctcct 360 gtaactggta atgatgttgg aattcgtaga gcagaaatta agcaagggat tcgtgaagtc 420 attttgtgta aggatcaaga tggaaaaatt ggactcaggc ttaaatcaat agataatggt 480 atatttgttc agctagtcca ggctaattct ccagcctcat tggttggtct gagatttggg 540 gaccaagtac ttcagatcaa tggtgaaaac tgtgcaggat ggagctctga taaagcgcac 600 aaggtgctca aacaggcttt tggagagaag attaccatga ccattcgtga caggcccttt 660 gaacggacga ttaccatgca taaggatagc actggacatg ttggttttat ctttaaaaat 720 ggaaaaataa catccatagt gaaagatagc tctgcagcca gaaatggtct tctcacggaa 780 cataacatct gtgaaatcaa tggacagaat gtcattggat tgaaggactc tcaaattgca 840 gacatactgt caacatctgg gactgtagtt actattacaa tcatgcctgc ttttatcttt 900 gaacatatta ttaagcggat ggcaccaagc attatgaaaa gcctaatgga ccacaccatt 960 cctgaggttt aaaattcacg gcaccatgga aatgtagctg aacgtctcca gtttccttct 1020 ttggcaactt ctgtattatg cacgtgaagc cttcccggag ccagcgagca tatgctgcat 1080 gaggaccttt ctatcttaca ttatggctgg gaatcttact ctttcatctg ataccttgtt 1140 cagatttcaa aatagttgta gccttatcct ggttttacag atgtgaaact ttcaagagat 1200 ttactgactt tcctagaata gtttctctac tggaaacctg atgcttttat aagccattgt 1260 gattaggatg actgttacag gcttagcttt gtgtgaaaac cagtcacctt tctcctaggt 1320 aatgagtagt gctgttcata ttactttagt tctatagcat actgcatctt taacatgcta 1380 tcatagtaca tttagaatga ttgcctttga tttttttttt aaattctgtg tgtgtgtgtg 1440 taaaatgcca attaagaaca ctggtttcat tccatgtaag cattaaacag tgtatgtagg 1500 tttcaagaga ttgtgatgat tcttaaattt taactacctt cacttaatat gcttgaactg 1560 tcgccttaac tatgttaagc atctagacta aaagccaaaa tataattatt gctgcctttc 1620 taaaaaccca aaatgtagtt ctctattaac ctgaaatgta cactagccca gaacagttta 1680 atggtactta ctgagctata gcatagctgc ttagttgttt ttgagagttt ttagtcaaca 1740 cataatggaa acttctttct tctaaaagtt gccagtgcca cttttaagaa gtgaatcact 1800 atatgtgatg taaaagttat tacactaaac aggataaact tttgactccc cttttgttca 1860 tttgtggatt aagtggtata atacttaatt ttggcatttg actcttaaga ttatgtaacc 1920 tagctacttt gggatggtct tagaatattt ttctgataac ttgttccttt tcctgactcc 1980 tccttgcaaa caaaatgata gttgacactt tatcctgatt tttttcttct ttttggttta 2040 tgtctattct aattaaatat gtataaat 2068 <210> 433 <211> 1723 <212> DNA <213> Homo (Homo sapiens) <400> 433 tttctttgtt aagtcgttcc ctctacaaag gacttcctag tgggtgtgaa aggcagcggt 60 ggccacagag gcggcggaga gatggccttc agcggttccc aggctcccta cctgagtcca 120 gctgtcccct tttctgggac tattcaagga ggtctccagg acggacttca gatcactgtc 180 aatgggaccg ttctcagctc cagtggaacc aggtttgctg tgaactttca gactggcttc 240 agtggaaatg acattgcctt ccacttcaac cctcggtttg aagatggagg gtacgtggtg 300 tgcaacacga ggcagaacgg aagctggggg cccgaggaga ggaagacaca catgcctttc 360 cagaagggga tgccctttga cctctgcttc ctggtgcaga gctcagattt caaggtgatg 420 gtgaacggga tcctcttcgt gcagtacttc caccgcgtgc ccttccaccg tgtggacacc 480 atctccgtca atggctctgt gcagctgtcc tacatcagct tccagaaccc ccgcacagtc 540 cctgttcagc ctgcctttcc acggtgccgt tctcccagcc tgtctgtttc ccacccaggc 600 ccagggggcg cagacaaaaa cctcccggcg tgtggcctgc caacccggct cccattaccc 660 agacagtcat ccacacagtg cagagcgccc ctggacagat gttctctact cccgccatcc 720 cacctatgat gtacccccac cccgcctatc cgatgccttt catcaccacc attctgggag 780 ggctgtaccc atccaagtcc atcctcctgt caggcactgt cctgcccagt gctcagaggt 840 tccacatcaa cctgtgctct gggaaccaca tcgccttcca cctgaacccc cgttttgatg 900 agaatgctgt ggtccgcaac acccagatcg acaactcctg ggggtctgag gagcgaagtc 960 tgccccgaaa aatgcccttc gtccgtggcc agagcttctc agtgtggatc ttgtgtgaag 1020 ctcactgcct caaggtggcc gtggatggtc agcacctgtt tgaatactac catcgcctga 1080 ggaacctgcc caccatcaac agactggaag tggggggcga catccagctg acccatgtgc 1140 agacataggc ggcttcctgg ccctggggcc gggggctggg gtgtggggca gtctgggtcc 1200 tctcatcatc cccacttccc aggcccagcc tttccaaccc tgcctgggat ctgggcttta 1260 atgcagaggc catgtccttg tctggtcctg cttctggcta cagccaccct ggaacggaga 1320 aggcagctga cggggattgc cttcctcagc cgcagcagca cctggggctc cagctgctgg 1380 aatcctacca tcccaggagg caggcacagc cagggagagg ggaggagtgg gcagtgaaga 1440 tgaagcccca tgctcagtcc cctcccatcc cccacgcagc tccaccccag tcccaagcca 1500 ccagctgtct gctcctggtg ggaggtggcc tcctcagccc ctcctctctg acctttaacc 1560 tcactctcac cttgcaccgt gcaccaaccc ttcacccctc ctggaaagca ggcctgatgg 1620 cttcccactg gcctccacca cctgaccaga gtgttctctt cagaggactg gctcctttcc 1680 cagtgtcctt aaaataaaga aatgaaaatg cttgttggca cat 1723 <210> 434 <211> 1702 <212> PRT <213> Homo (Homo sapiens) <400> 434 Ala Ala Val Leu Gln Ser Cys Thr Ala Phe Ile Glu Arg Tyr Gly Ile ...

5??????????????????10??????????????????15Val?Asp?Gly?Ile?Tyr?Arg?Leu?Ser?Gly?Val?Ala?Ser?Asn?Ile?Gln?Arg

20??????????????????25??????????????????30Leu?Arg?His?Glu?Phe?Asp?Ser?Glu?His?Val?Pro?Asp?Leu?Thr?Lys?Glu

35??????????????????40??????????????????45Pro?Tyr?Val?Gln?Asp?Ile?His?Ser?Val?Gly?Ser?Leu?Cys?Lys?Leu?Tyr

50??????????????????55??????????????????60Phe?Arg?Glu?Leu?Pro?Asn?Pro?Leu?Leu?Thr?Tyr?Gln?Leu?Tyr?Glu?Lys?65??????????????????70??????????????????75??????????????????80Phe?Ser?Asp?Ala?Val?Ser?Ala?Ala?Thr?Asp?Glu?Glu?Arg?Leu?Ile?Lys

85??????????????????90??????????????????95Ile?His?Asp?Val?Ile?Gln?Gln?Leu?Pro?Pro?Pro?His?Tyr?Arg?Thr?Leu

100?????????????????105?????????????????110Glu?Phe?Leu?Met?Arg?His?Leu?Ser?Leu?Leu?Ala?Asp?Tyr?Cys?Ser?Ile

115?????????????????120?????????????????125Thr?Asn?Met?His?Ala?Lys?Asn?Leu?Ala?Ile?Val?Trp?Ala?Pro?Asn?Leu

130?????????????????135?????????????????140Leu?Arg?Ser?Lys?Gln?Ile?Glu?Ser?Ala?Cys?Phe?Ser?Gly?Thr?Ala?Ala145?????????????????150?????????????????155?????????????????160Phe?Met?Glu?Val?Arg?Ile?Gln?Ser?Val?Val?Val?Glu?Phe?Ile?Leu?Asn

165?????????????????170?????????????????175His?Val?Asp?Val?Leu?Phe?Ser?Gly?Arg?Ile?Ser?Met?Ala?Met?Gln?Glu

180?????????????????185?????????????????190Gly?Ala?Ala?Ser?Leu?Ser?Arg?Pro?Lys?Ser?Leu?Leu?Val?Ser?Ser?Pro

195?????????????????200?????????????????205Ser?Thr?Lys?Leu?Leu?Thr?Leu?Glu?Glu?Ala?Gln?Ala?Arg?Thr?Gln?Ala

210?????????????????215?????????????????220Gln?Val?Asn?Ser?Pro?Ile?Val?Thr?Glu?Asn?Lys?Tyr?Ile?Glu?Val?Gly225?????????????????230?????????????????235?????????????????240Glu?Gly?Pro?Ala?Ala?Leu?Gln?Gly?Lys?Phe?His?Thr?Ile?Ile?Glu?Phe

245?????????????????250?????????????????255Pro?Leu?Glu?Arg?Lys?Arg?Pro?Gln?Asn?Lys?Met?Lys?Lys?Ser?Pro?Val

260?????????????????265?????????????????270Gly?Ser?Trp?Arg?Ser?Phe?Phe?Asn?Leu?Gly?Lys?Ser?Ser?Ser?Val?Ser

275?????????????????280?????????????????285Lys?Arg?Lys?Leu?Gln?Arg?Asn?Glu?Ser?Glu?Pro?Ser?Glu?Met?Lys?Ala

290?????????????????295?????????????????300Met?Ala?Leu?Lys?Gly?Gly?Arg?Ala?Glu?Gly?Thr?Leu?Arg?Ser?Ala?Lys305?????????????????310?????????????????315?????????????????320Ser?Glu?Glu?Ser?Leu?Thr?Ser?Leu?His?Ala?Val?Asp?Gly?Asp?Ser?Lys

325?????????????????330?????????????????335Leu?Phe?Arg?Pro?Arg?Arg?Pro?Arg?Ser?Ser?Ser?Asp?Ala?Leu?Ser?Ala

340?????????????????345?????????????????350Ser?Phe?Asn?Gly?Glu?Met?Leu?Gly?Asn?Arg?Cys?Asn?Ser?Tyr?Asp?Asn

355?????????????????360?????????????????365Leu?Pro?His?Asp?Asn?Glu?Ser?Glu?Glu?Glu?Gly?Gly?Leu?Leu?His?Ile

370?????????????????375?????????????????380Pro?Ala?Leu?Met?Ser?Pro?His?Ser?Ala?Glu?Asp?Val?Asp?Leu?Ser?Pro385?????????????????390?????????????????395?????????????????400Pro?Asp?Ile?Gly?Val?Ala?Ser?Leu?Asp?Phe?Asp?Pro?Met?Ser?Phe?Gln

405?????????????????410?????????????????415Cys?Ser?Pro?Pro?Lys?Ala?Glu?Ser?Glu?Cys?Leu?Glu?Ser?Gly?Ala?Ser

420?????????????????425?????????????????430Phe?Leu?Asp?Ser?Pro?Gly?Tyr?Ser?Lys?Asp?Lys?Pro?Ser?Ala?Asn?Lys

435?????????????????440?????????????????445Lys?Asp?Ala?Glu?Thr?Gly?Ser?Ser?Gln?Cys?Gln?Thr?Pro?Gly?Ser?Thr

450?????????????????455?????????????????460Ala?Ser?Ser?Glu?Pro?Val?Ser?Pro?Leu?Gln?Glu?Lys?Leu?Ser?Pro?Phe465?????????????????470?????????????????475?????????????????480Phe?Thr?Leu?Asp?Leu?Ser?Pro?Thr?Glu?Asp?Lys?Ser?Ser?Lys?Pro?Ser

485?????????????????490?????????????????495Ser?Phe?Thr?Glu?Lys?Val?Val?Tyr?Ala?Phe?Ser?Pro?Lys?Ile?Gly?Arg

500?????????????????505?????????????????510Lys?Leu?Ser?Lys?Ser?Pro?Ser?Met?Ser?Ile?Ser?Glu?Pro?Ile?Ser?Val

515?????????????????520?????????????????525Thr?Leu?Pro?Pro?Arg?Val?Ser?Glu?Val?Ile?Gly?Thr?Val?Ser?Asn?Thr

530?????????????????535?????????????????540Thr?Ala?Gln?Asn?Ala?Ser?Ser?Ser?Thr?Trp?Asp?Lys?Cys?Val?Glu?Glu545?????????????????550?????????????????555?????????????????560Arg?Asp?Ala?Thr?Asn?Arg?Ser?Pro?Thr?Gln?Ile?Val?Lys?Met?Lys?Thr

565?????????????????570?????????????????575Asn?Glu?Thr?Val?Ala?Gln?Glu?Ala?Tyr?Glu?Ser?Glu?Val?Gln?Pro?Leu

580?????????????????585?????????????????590Asp?Gln?Val?Ala?Ala?Glu?Glu?Val?Glu?Leu?Pro?Gly?Lys?Glu?Asp?Gln

595?????????????????600?????????????????605Ser?Val?Ser?Ser?Ser?Gln?Ser?Lys?Ala?Val?Ala?Ser?Gly?Gln?Thr?Gln

610?????????????????615?????????????????620Thr?Gly?Ala?Val?Thr?His?Asp?Pro?Pro?Gln?Asp?Ser?Val?Pro?Val?Ser625?????????????????630?????????????????635?????????????????640Ser?Val?Ser?Leu?Ile?Pro?Pro?Pro?Pro?Pro?Pro?Lys?Asn?Val?Ala?Arg

645?????????????????650?????????????????655Met?Leu?Ala?Leu?Ala?Leu?Ala?Glu?Ser?Ala?Gln?Gln?Ala?Ser?Thr?Gln

660?????????????????665?????????????????670Ser?Leu?Lys?Arg?Pro?Gly?Thr?Ser?Gln?Ala?Gly?Tyr?Thr?Asn?Tyr?Gly

675?????????????????680?????????????????685Asp?Ile?Ala?Val?Ala?Thr?Thr?Glu?Asp?Asn?Leu?Ser?Ser?Ser?Tyr?Ser

690?????????????????695?????????????????700Ala?Val?Ala?Leu?Asp?Lys?Ala?Tyr?Phe?Gln?Thr?Asp?Arg?Pro?Ala?Glu705?????????????????710?????????????????715?????????????????720Gln?Phe?His?Leu?Gln?Asn?Asn?Ala?Pro?Gly?Asn?Cys?Asp?His?Pro?Leu

725?????????????????730?????????????????735Pro?Glu?Thr?Thr?Ala?Thr?Gly?Asp?Pro?Thr?His?Ser?Asn?Thr?Thr?Glu

740?????????????????745?????????????????750Ser?Gly?Glu?Gln?His?His?Gln?Val?Asp?Leu?Thr?Gly?Asn?Gln?Pro?His

755?????????????????760?????????????????765Gln?Ala?Tyr?Leu?Ser?Gly?Asp?Pro?Glu?Lys?Ala?Arg?Ile?Thr?Ser?Val

770?????????????????775?????????????????780Pro?Leu?Asp?Ser?Glu?Lys?Ser?Asp?Asp?His?Val?Ser?Phe?Pro?Glu?Asp785?????????????????790?????????????????795?????????????????800Gln?Ser?Gly?Lys?Asn?Ser?Met?Pro?Thr?Val?Ser?Phe?Leu?Asp?Gln?Asp

805?????????????????810?????????????????815Gln?Ser?Pro?Pro?Arg?Phe?Tyr?Ser?Gly?Asp?Gln?Pro?Pro?Ser?Tyr?Leu

820?????????????????825?????????????????830Gly?Ala?Ser?Val?Asp?Lys?Leu?His?His?Pro?Leu?Glu?Phe?Ala?Asp?Lys

835?????????????????840?????????????????845Ser?Pro?Thr?Pro?Pro?Asn?Leu?Pro?Ser?Asp?Lys?Ile?Tyr?Pro?Pro?Ser

850?????????????????855?????????????????860Gly?Ser?Pro?Glu?Glu?Asn?Thr?Ser?Thr?Ala?Thr?Met?Thr?Tyr?Met?Thr865?????????????????870?????????????????875?????????????????880Thr?Thr?Pro?Ala?Thr?Ala?Gln?Met?Ser?Thr?Lys?Glu?Ala?Ser?Trp?Asp

885?????????????????890?????????????????895Val?Ala?Glu?Gln?Pro?Thr?Thr?Ala?Asp?Phe?Ala?Ala?Ala?Thr?Leu?Gln

900?????????????????905?????????????????910Arg?Thr?His?Arg?Thr?Asn?Arg?Pro?Leu?Pro?Pro?Pro?Pro?Ser?Gln?Arg

915?????????????????920?????????????????925Ser?Ala?Glu?Gln?Pro?Pro?Val?Val?Gly?Gln?Val?Gln?Ala?Ala?Thr?Asn

930?????????????????935?????????????????940Ile?Gly?Leu?Asn?Asn?Ser?His?Lys?Val?Gln?Gly?Val?Val?Pro?Val?Pro945?????????????????950?????????????????955?????????????????960Glu?Arg?Pro?Pro?Glu?Pro?Arg?Ala?Met?Asp?Asp?Pro?Ala?Ser?Ala?Phe

965?????????????????970?????????????????975Ile?Ser?Asp?Ser?Gly?Ala?Ala?Ala?Ala?Gln?Cys?Pro?Met?Ala?Thr?Ala

980?????????????????985?????????????????990Val?Gln?Pro?Gly?Leu?Pro?Glu?Lys?Val?Arg?Asp?Gly?Ala?Arg?Val?Pro

995?????????????????1000????????????????1005Leu?Leu?His?Leu?Arg?Ala?Glu?Ser?Val?Pro?Ala?His?Pro?Cys?Gly?Phe

1010????????????????1015????????????????1020Pro?Ala?Pro?Leu?Pro?Pro?Thr?Arg?Met?Met?Glu?Ser?Lys?Met?Ile?Ala1025????????????????1030????????????????1035????????????????1040Ala?Ile?His?Ser?Ser?Ser?Ala?Asp?Ala?Thr?Ser?Ser?Ser?Asn?Tyr?His

1045????????????????1050????????????????1055Ser?Phe?Val?Thr?Ala?Ser?Ser?Thr?Ser?Val?Asp?Asp?Ala?Leu?Pro?Leu

1060????????????????1065????????????????1070Pro?Leu?Pro?Val?Pro?Gln?Pro?Lys?His?Ala?Ser?Gln?Lys?Thr?Val?Tyr

1075????????????????1080????????????????1085Ser?Ser?Phe?Ala?Arg?Pro?Asp?Val?Thr?Thr?Glu?Pro?Phe?Gly?Pro?Asp

1090????????????????1095????????????????1100Asn?Cys?Leu?His?Phe?Asn?Met?Thr?Pro?Asn?Cys?Gln?Tyr?Arg?Pro?Gln1105????????????????1110????????????????1115????????????????1120Ser?Val?Pro?Pro?His?His?Asn?Lys?Leu?Glu?Gln?His?Gln?Val?Tyr?Gly

1125????????????????1130????????????????1135Ala?Arg?Ser?Glu?Pro?Pro?Ala?Ser?Met?Gly?Leu?Arg?Tyr?Asn?Thr?Tyr

1140????????????????1145????????????????1150Val?Ala?Pro?Gly?Arg?Asn?Ala?Ser?Gly?His?His?Ser?Lys?Pro?Cys?Ser

1155????????????????1160????????????????1165Arg?Val?Glu?Tyr?Val?Ser?Ser?Leu?Ser?Ser?Ser?Val?Arg?Asn?Thr?Cys

1170????????????????1175????????????????1180Tyr?Pro?Glu?Asp?Ile?Pro?Pro?Tyr?Pro?Thr?Ile?Arg?Arg?Val?Gln?Ser1185????????????????1190????????????????1195????????????????1200Leu?His?Ala?Pro?Pro?Ser?Ser?Met?Ile?Arg?Ser?Val?Pro?Ile?Ser?Arg

1205????????????????1210????????????????1215Thr?Glu?Val?Pro?Pro?Asp?Asp?Glu?Pro?Ala?Tyr?Cys?Pro?Arg?Pro?Leu

1220????????????????1225????????????????1230Tyr?Gln?Tyr?Lys?Pro?Tyr?Gln?Ser?Ser?Gln?Ala?Arg?Ser?Asp?Tyr?His

1235????????????????1240????????????????1245Val?Thr?Gln?Leu?Gln?Pro?Tyr?Phe?Glu?Asn?Gly?Arg?Val?His?Tyr?Arg

1250????????????????1255????????????????1260Tyr?Ser?Pro?Tyr?Ser?Ser?Ser?Ser?Ser?Ser?Tyr?Tyr?Ser?Pro?Asp?Gly1265????????????????1270????????????????1275????????????????1280Ala?Leu?Cys?Asp?Val?Asp?Ala?Tyr?Gly?Thr?Val?Gln?Leu?Arg?Pro?Leu

1285????????????????1290????????????????1295His?Arg?Leu?Pro?Asn?Arg?Asp?Phe?Ala?Phe?Tyr?Asn?Pro?Arg?Leu?Gln

1300????????????????1305????????????????1310Gly?Lys?Ser?Leu?Tyr?Ser?Tyr?Ala?Gly?Leu?Ala?Pro?Arg?Pro?Arg?Ala

1315????????????????1320????????????????1325Asn?Val?Thr?Gly?Tyr?Phe?Ser?Pro?Asn?Asp?His?Asn?Val?Val?Ser?Met

1330????????????????1335????????????????1340Pro?Pro?Ala?Ala?Asp?Val?Lys?His?Thr?Tyr?Thr?Ser?Trp?Asp?Leu?Glu1345????????????????1350????????????????1355????????????????1360Asp?Met?Glu?Lys?Tyr?Arg?Met?Gln?Ser?Ile?Arg?Arg?Glu?Ser?Arg?Ala

1365????????????????1370????????????????1375Arg?Gln?Lys?Val?Lys?Gly?Pro?Val?Met?Ser?Gln?Tyr?Asp?Asn?Met?Thr

1380????????????????1385????????????????1390Pro?Ala?Val?Gln?Asp?Asp?Leu?Gly?Gly?Ile?Tyr?Val?Ile?His?Leu?Arg

1395????????????????1400????????????????1405Ser?Lys?Ser?Asp?Pro?Gly?Lys?Thr?Gly?Leu?Leu?Ser?Val?Ala?Glu?Gly

1410????????????????1415????????????????1420Lys?Glu?Ser?Arg?His?Ala?Ala?Lys?Ala?Ile?Ser?Pro?Glu?Gly?Glu?Asp1425????????????????1430????????????????1435????????????????1440Arg?Phe?Tyr?Arg?Arg?His?Pro?Glu?Ala?Glu?Met?Asp?Arg?Ala?His?His

1445????????????????1450????????????????1455His?Gly?Gly?His?Gly?Ser?Thr?Gln?Pro?Glu?Lys?Pro?Ser?Leu?Pro?Gln

1460????????????????1465????????????????1470Lys?Gln?Ser?Ser?Leu?Arg?Ser?Arg?Lys?Leu?Pro?Asp?Met?Gly?Cys?Ser

1475????????????????1480????????????????1485Leu?Pro?Glu?His?Arg?Ala?His?Gln?Glu?Ala?Ser?His?Arg?Gln?Phe?Cys

1490????????????????1495????????????????1500Glu?Ser?Lys?Asn?Gly?Pro?Pro?Tyr?Pro?Gln?Gly?Ala?Gly?Gln?Leu?Asp1505????????????????1510????????????????1515????????????????1520Tyr?Gly?Ser?Lys?Gly?Ile?Pro?Asp?Thr?Ser?Glu?Pro?Val?Ser?Tyr?His

1525????????????????1530????????????????1535Asn?Ser?Gly?Val?Lys?Tyr?Ala?Ala?Ser?Gly?Gln?Glu?Ser?Leu?Arg?Leu

1540????????????????1545????????????????1550Asn?His?Lys?Glu?Val?Arg?Leu?Ser?Lys?Glu?Met?Glu?Arg?Pro?Trp?Val

1555????????????????1560????????????????1565Arg?Gln?Pro?Ser?Ala?Pro?Glu?Lys?His?Ser?Arg?Asp?Cys?Tyr?Lys?Glu

1570????????????????1575????????????????1580Glu?Glu?His?Leu?Thr?Gln?Ser?Ile?Val?Pro?Pro?Pro?Lys?Pro?Glu?Arg1585????????????????1590????????????????1595????????????????1600Ser?His?Ser?Leu?Lys?Leu?His?His?Thr?Gln?Asn?Val?Glu?Arg?Asp?Pro

1605????????????????1610????????????????1615Ser?Val?Leu?Tyr?Gln?Tyr?Gln?Pro?His?Gly?Lys?Arg?Gln?Ser?Ser?Val

1620????????????????1625????????????????1630Thr?Val?Val?Ser?Gln?Tyr?Asp?Asn?Leu?Glu?Asp?Tyr?His?Ser?Leu?Pro

1635????????????????1640????????????????1645Gln?His?Gln?Arg?Gly?Val?Phe?Gly?Gly?Gly?Gly?Met?Gly?Thr?Tyr?Val

1650????????????????1655????????????????1660Pro?Pro?Gly?Phe?Pro?His?Pro?Gln?Ser?Arg?Thr?Tyr?Ala?Thr?Ala?Leu1665????????????????1670????????????????1675????????????????1680Gly?Gln?Gly?Ala?Phe?Leu?Pro?Ala?Glu?Leu?Ser?Leu?Gln?His?Pro?Glu

1685????????????????1690????????????????1695Thr?Gln?Ile?His?Ala?Glu

1700＜210〉435＜211〉160＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉435Pro Phe Gln Gln Val Gly Arg Cys Asn Pro Ser Pro Gln Thr Arg Pro

5??????????????????10??????????????????15Gly?Pro?Ala?Ser?Lys?Val?Lys?Gln?Asp?Met?Pro?Pro?Pro?Gly?Gly?Tyr

20??????????????????25??????????????????30Gly?Pro?Ile?Asp?Tyr?Lys?Arg?Asn?Leu?Pro?Arg?Arg?Gly?Leu?Ser?Gly

35??????????????????40??????????????????45Tyr?Ser?Met?Leu?Ala?Ile?Gly?Ile?Gly?Thr?Leu?Ile?Tyr?Gly?His?Trp

50??????????????????55??????????????????60Ser?Ile?Met?Lys?Trp?Asn?Arg?Glu?Arg?Arg?Arg?Leu?Gln?Ile?Glu?Asp?65??????????????????70??????????????????75??????????????????80Phe?Glu?Ala?Arg?Ile?Ala?Leu?Leu?Pro?Leu?Leu?Gln?Ala?Glu?Thr?Asp

85??????????????????90??????????????????95Arg?Arg?Thr?Leu?Gln?Met?Leu?Arg?Glu?Asn?Leu?Glu?Glu?Glu?Ala?Ile

100?????????????????105?????????????????110Ile?Met?Lys?Asp?Val?Pro?Asp?Trp?Lys?Val?Gly?Glu?Ser?Val?Phe?His

115?????????????????120?????????????????125Thr?Thr?Arg?Trp?Val?Pro?Pro?Leu?Ile?Gly?Glu?Leu?Tyr?Gly?Leu?Arg

130 135 140Thr Thr Glu Glu Ala Leu His Ala Ser His Gly Phe Met Trp Tyr Thr145,150 155 160＜210〉436＜211〉396＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉436Arg Ala Gln Glu Ala Ala Ala Ala Ala Ala Asp Gly Pro Pro Ala Ala

5??????????????????10??????????????????15Asp?Gly?Glu?Asp?Gly?Gln?Asp?Pro?His?Ser?Lys?His?Leu?Tyr?Thr?Ala

20??????????????????25??????????????????30Asp?Met?Phe?Thr?His?Gly?Ile?Gln?Ser?Ala?Ala?His?Phe?Val?Met?Phe

35?????????????????40?????????????????45Phe?Ala?Pro?Trp?Cys?Gly?His?Cys?Gln?Arg?Leu?Gln?Pro?Thr?Trp?Asn

50??????????????????55??????????????????60Asp?Leu?Gly?Asp?Lys?Tyr?Asn?Ser?Met?Glu?Asp?Ala?Lys?Val?Tyr?Val?65??????????????????70??????????????????75??????????????????80Ala?Lys?Val?Asp?Cys?Thr?Ala?His?Ser?Asp?Val?Cys?Ser?Ala?Gln?Gly

85??????????????????90??????????????????95Val?Arg?Gly?Tyr?Pro?Thr?Leu?Lys?Leu?Phe?Lys?Pro?Gly?Gln?Glu?Ala

100?????????????????105?????????????????110Val?Lys?Tyr?Gln?Gly?Pro?Arg?Asp?Phe?Gln?Thr?Leu?Glu?Asn?Trp?Met

115?????????????????120?????????????????125Leu?Gln?Thr?Leu?Asn?Glu?Glu?Pro?Val?Thr?Pro?Glu?Pro?Glu?Val?Glu

130?????????????????135?????????????????140Pro?Pro?Ser?Ala?Pro?Glu?Leu?Lys?Gln?Gly?Leu?Tyr?Glu?Leu?Ser?Ala145?????????????????150?????????????????155?????????????????160Ser?Asn?Phe?Glu?Leu?His?Val?Ala?Gln?Gly?Asp?His?Phe?Ile?Lys?Phe

165?????????????????170?????????????????175Phe?Ala?Pro?Trp?Cys?Gly?His?Cys?Lys?Ala?Leu?Ala?Pro?Thr?Trp?Glu

180?????????????????185?????????????????190Gln?Leu?Ala?Leu?Gly?Leu?Glu?His?Ser?Glu?Thr?Val?Lys?Ile?Gly?Lys

195?????????????????200?????????????????205Val?Asp?Cys?Thr?Gln?His?Tyr?Glu?Leu?Cys?Ser?Gly?Asn?Gln?Val?Arg

210?????????????????215?????????????????220Gly?Tyr?Pro?Thr?Leu?Leu?Trp?Phe?Arg?Asp?Gly?Lys?Lys?Val?Asp?Gln225?????????????????230?????????????????235?????????????????240Tyr?Lys?Gly?Lys?Arg?Asp?Leu?Glu?Ser?Leu?Arg?Glu?Tyr?Val?Glu?Ser

245?????????????????250?????????????????255Gln?Leu?Gln?Arg?Thr?Glu?Thr?Gly?Ala?Thr?Glu?Thr?Val?Thr?Pro?Ser

260?????????????????265?????????????????270Glu?Ala?Pro?Val?Leu?Ala?Ala?Glu?Pro?Glu?Ala?Asp?Lys?Gly?Thr?Val

275?????????????????280?????????????????285Leu?Ala?Leu?Thr?Glu?Asn?Thr?Phe?Asp?Asp?ThrIle?Ala?Glu?Gly?Ile

290?????????????????295?????????????????300Thr?Phe?Ile?Lys?Phe?Tyr?Ala?Pro?Trp?Cys?Gly?His?Cys?Lys?Thr?Leu305?????????????????310?????????????????315?????????????????320Ala?Pro?Thr?Trp?Glu?Glu?Leu?Ser?Lys?Lys?Glu?Phe?Pro?Gly?Leu?Ala

325?????????????????330?????????????????335Gly?Val?Lys?Ile?Ala?Glu?Val?Asp?Cys?Thr?Ala?Glu?Arg?Asn?Ile?Cys

340?????????????????345?????????????????350Ser?Lys?Tyr?Ser?Val?Arg?Gly?Tyr?Pro?Thr?Leu?Leu?Leu?Phe?Arg?Gly

355?????????????????360?????????????????365Gly?Lys?Lys?Val?Ser?Glu?His?Ser?Gly?Gly?Arg?Asp?Leu?Asp?Ser?Leu

370 375 380His Arg Phe Val Leu Ser Gln Ala Lys Asp Glu Leu385,390 395＜210〉437＜211〉92＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉437Ala Glu Met Asp Pro Leu Arg Ala Gln Gln Leu Ala Ala Glu Leu Glu

5??????????????????10??????????????????15Val?Glu?Met?Met?Ala?Asp?Met?Tyr?Asn?Arg?Met?Thr?Ser?Ala?Cys?His

20??????????????????25??????????????????30Arg?Lys?Cys?Val?Pro?Pro?His?Tyr?Lys?Glu?Ala?Glu?Leu?Ser?Lys?Gly

35??????????????????40??????????????????45Glu?Ser?Val?Cys?Leu?Asp?Arg?Cys?Val?Ser?Lys?Tyr?Leu?Asp?Ile?His

50??????????????????55??????????????????60Glu?Arg?Met?Gly?Lys?Lys?Leu?Thr?Glu?Leu?Ser?Met?Gln?Asp?Glu?Glu?65??????????????????70??????????????????75??????????????????80Leu?Met?Lys?Arg?Val?Gln?Gln?Ser?Ser?Gly?ProAla

85 90＜210〉438＜211〉303＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉438Lys Asn Pro Ala Lys Met Ser Leu Tyr Pro Ser Leu Glu Asp Leu Lys

5??????????????????10??????????????????15Val?Asp?Lys?Val?Ile?Gln?Ala?Gln?Thr?Ala?Phe?Ser?Ala?Asn?Pro?Ala

20??????????????????25??????????????????30Asn?Pro?Ala?Ile?Leu?Ser?Glu?Ala?Ser?Ala?Pro?Ile?Pro?His?Asp?Gly

35??????????????????40??????????????????45Asn?Leu?Tyr?Pro?Arg?Leu?Tyr?Pro?Glu?Leu?Ser?Gln?Tyr?Met?Gly?Leu

50??????????????????55??????????????????60Ser?Leu?Asn?Glu?Glu?Glu?Ile?Arg?Ala?Asn?Val?Ala?Val?Val?Ser?Gly?65??????????????????70??????????????????75??????????????????80Ala?Pro?Leu?Gln?Gly?Gln?Leu?Val?Ala?Arg?Pro?Ser?Ser?Ile?Asn?Tyr

85??????????????????90??????????????????95Met?Val?Ala?Pro?Val?Thr?Gly?Asn?Asp?Val?Gly?Ile?Arg?Arg?Ala?Glu

100?????????????????105?????????????????110Ile?Lys?Gln?Gly?Ile?Arg?Glu?Val?Ile?Leu?Cys?Lys?Asp?Gln?Asp?Gly

115?????????????????120?????????????????125Lys?Ile?Gly?Leu?Arg?Leu?Lys?Ser?Ile?Asp?Asn?Gly?Ile?Phe?Val?Gln

130?????????????????135?????????????????140Leu?Val?Gln?Ala?Asn?Ser?Pro?Ala?Ser?Leu?Val?Gly?Leu?Arg?Phe?Gly145?????????????????150?????????????????155?????????????????160Asp?Gln?Val?Leu?Gln?Ile?Asn?Gly?Glu?Asn?Cys?Ala?Gly?Trp?Ser?Ser

165?????????????????170?????????????????175Asp?Lys?Ala?His?Lys?Val?Leu?Lys?Gln?Ala?Phe?Gly?Glu?Lys?Ile?Thr

180?????????????????185?????????????????190Met?Thr?Ile?Arg?Asp?Arg?Pro?Phe?Glu?Arg?Thr?Ile?Thr?Met?His?Lys

195?????????????????200?????????????????205Asp?Ser?Thr?Gly?His?Val?Gly?Phe?Ile?Phe?Lys?Asn?Gly?Lys?Ile?Thr

210?????????????????215?????????????????220Ser?Ile?Val?Lys?Asp?Ser?Ser?Ala?Ala?Arg?Asn?Gly?Leu?Leu?Thr?Glu225?????????????????230?????????????????235?????????????????240His?Asn?Ile?Cys?Glu?Ile?Asn?Gly?Gln?Asn?Val?Ile?Gly?Leu?Lys?Asp

245?????????????????250?????????????????255Ser?Gln?Ile?Ala?Asp?Ile?Leu?Ser?Thr?Ser?Gly?Thr?Val?Val?Thr?Ile

260?????????????????265?????????????????270Thr?Ile?Met?Pro?Ala?Phe?Ile?Phe?Glu?His?Ile?Ile?Lys?Arg?Met?Ala

275?????????????????280?????????????????285Pro?Ser?Ile?Met?Lys?Ser?Leu?Met?Asp?His?Thr?Ile?Pro?Glu?Val

290 295 300＜210〉439＜211〉378＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉439Val Val Pro Ser Thr Lys Asp Phe Leu Val Gly Val Lys Gly Ser Gly

5??????????????????10??????????????????15Gly?His?Arg?Gly?Gly?Gly?Glu?Met?Ala?Phe?Ser?Gly?Ser?Gln?Ala?Pro

20??????????????????25??????????????????30Tyr?Leu?Ser?Pro?Ala?Val?Pro?Phe?Ser?Gly?Thr?Ile?Gln?Gly?Gly?Leu

35??????????????????40??????????????????45Gln?Asp?Gly?Leu?Gln?Ile?Thr?Val?Asn?Gly?Thr?Val?Leu?Ser?Ser?Ser

50??????????????????55??????????????????60Gly?Thr?Arg?Phe?Ala?Val?Asn?Phe?Gln?Thr?Gly?Phe?Ser?Gly?Asn?Asp?65??????????????????70??????????????????75??????????????????80Ile?Ala?Phe?His?Phe?Asn?Pro?Arg?Phe?Glu?Asp?Gly?Gly?Tyr?Val?Val

85??????????????????90??????????????????95Cys?Asn?Thr?Arg?Gln?Asn?Gly?Ser?Trp?Gly?Pro?Glu?Glu?Arg?Lys?Thr

100?????????????????105?????????????????110His?Met?Pro?Phe?Gln?Lys?Gly?Met?Pro?Phe?Asp?Leu?Cys?Phe?Leu?Val

115?????????????????120?????????????????125Gln?Ser?Ser?Asp?Phe?Lys?Val?Met?Val?Asn?Gly?Ile?Leu?Phe?Val?Gln

130?????????????????135?????????????????140Tyr?Phe?His?Arg?Val?Pro?Phe?His?Arg?Val?Asp?Thr?Ile?Ser?Val?Asn145?????????????????150?????????????????155?????????????????160Gly?Ser?Val?Gln?Leu?Ser?Tyr?Ile?Ser?Phe?Gln?Asn?Pro?Arg?Thr?Val

165?????????????????170?????????????????175Pro?Val?Gln?Pro?Ala?Phe?Ser?Thr?Val?Pro?Phe?Ser?Gln?Pro?Val?Cys

180?????????????????185?????????????????190Phe?Pro?Pro?Arg?Pro?Arg?Gly?Arg?Arg?Gln?Lys?Pro?Pro?Gly?Val?Trp

195?????????????????200?????????????????205Pro?Ala?Asn?Pro?Ala?Pro?Ile?Thr?Gln?Thr?Val?Ile?His?Thr?Val?Gln

210?????????????????215?????????????????220Ser?Ala?Pro?Gly?Gln?Met?Phe?Ser?Thr?Pro?Ala?Ile?Pro?Pro?Met?Met225?????????????????230?????????????????235?????????????????240Tyr?Pro?His?Pro?Ala?Tyr?Pro?Met?Pro?Phe?Ile?Thr?Thr?Ile?Leu?Gly

245?????????????????250?????????????????255Gly?Leu?Tyr?Pro?Ser?Lys?Ser?Ile?Leu?Leu?Ser?Gly?Thr?Val?Leu?Pro

260?????????????????265?????????????????270Ser?Ala?Gln?Arg?Phe?His?Ile?Asn?Leu?Cys?Ser?Gly?Asn?His?Ile?Ala

275?????????????????280?????????????????285Phe?His?Leu?Asn?Pro?Arg?Phe?Asp?Glu?Asn?Ala?Val?Val?Arg?Asn?Thr

290?????????????????295?????????????????300Gln?Ile?Asp?Asn?Ser?Trp?Gly?Ser?Glu?Glu?Arg?Ser?Leu?Pro?Arg?Lys305?????????????????310?????????????????315?????????????????320Met?Pro?Phe?Val?Arg?Gly?Gln?Ser?Phe?Ser?Val?Trp?Ile?Leu?Cys?Glu

325?????????????????330?????????????????335Ala?His?Cys?Leu?Lys?Val?Ala?Val?Asp?Gly?Gln?His?Leu?Phe?Glu?Tyr

340?????????????????345?????????????????350Tyr?His?Arg?Leu?Arg?Asn?Leu?Pro?Thr?Ile?Asn?Arg?Leu?Glu?Val?Gly

355?????????????????360?????????????????365Gly?Asp?Ile?Gln?Leu?Thr?His?Val?Gln?Thr

370375 <210> 440 <211> 2239 <212> DNA <213> Homo (Homo sapiens) <400> 440 ggaggttgaa gtgagcagag atcatgccag cctgggtgac agtgagactc tgtctcaaac 60 agaattaagg aaaaaagaaa gaaagaaaaa gagagagagg aaattccagg ccaattgtgg 120 catagatttt atcatattct ggattttttg gattcttttg ttttctcatc actggattca 180 ggaaagcctg ttgtgtccac catctccaaa ggaggttacc tgcagggaaa tgttaacggg 240 aggctgcctt ccctgggcaa caaggagcca cctgggcagg acgccttttc aggaagagac 300 gccttttcag gaagagacgc cttttcagga agagagaaag tgcagctgaa gaggaaagtc 360 actttactga ggggagtctc cattatcatt ggcaccatca ttggagcagg aatcttcatc 420 tctcctaagg gcgtgctcca gaacacgggc agcgtgggca tgtctctgac catctggacg 480 gtgtgtgggg tcctgtcact atttggagct ttgtcttatg ctgaattggg aacaactata 540 aagaaatctg gaggtcatta cacatatatt ttggaagtct ttggtccatt accagctttt 600 gtacgagtct gggtggaact cctcataata cgccctgcag ctactgctgt gatatccctg 660 gcatttggac gctacattct ggaaccattt tttattcaat gtgaaatccc tgaacttgcg 720 atcaagctca ttacagctgt gggcataact gtagtgatgg tcctaaatag catgagtgtc 780 agctggagcg cccggatcca gattttctta accttttgca agctcacagc aattct gata 840 attatagtcc ctggagttat gcagctaatt aaaggtcaaa cgcagaactt taaagacgcc 900 ttttcaggaa gagattcaag tattacgcgg ttgccactgg ctttttatta tggaatgtat 960 gcatatgctg gctggtttta cctcaacttt gttactgaag aagtagaaaa ccctgaaaaa 1020 accattcccc ttgcaatatg tatatccatg gccattgtca ccattggcta tgtgctgaca 1080 aatgtggcct actttacgac cattaatgct gaggagctgc tgctttcaaa tgcagtggca 1140 gtgacctttt ctgagcggct actgggaaat ttctcattag cagttccgat ctttgttgcc 1200 ctctcctgct ttggctccat gaacggtggt gtgtttgctg tctccaggtt attctatgtt 1260 gcgtctcgag agggtcacct tccagaaatc ctctccatga ttcatgtccg caagcacact 1320 cctctaccag ctgttattgt tttgcaccct ttgacaatga taatgctctt ctctggagac 1380 ctcgacagtc ttttgaattt cctcagtttt gccaggtggc tttttattgg gctggcagtt 1440 gctgggctga tttatcttcg atacaaatgc ccagatatgc atcgtccttt caaggtgcca 1500 ctgttcatcc cagctttgtt ttccttcaca tgcctcttca tggttgccct ttccctctat 1560 tcggacccat ttagtacagg gattggcttc gtcatcactc tgactggagt ccctgcgtat 1620 tatctcttta ttatatggga caagaaaccc aggtggttta gaataatgtc agagaaaata 1680 accagaacat tacaaataat actggaagtt gtaccagaag aagataagtt atgaactaat 1740 ggacttgaga tcttggcaat ctgcccaagg ggagacacaa aatagggatt tttacttcat 1800 tttctgaaag tctagagaat tacaactttg gtgataaaca aaaggagtca gttattttta 1860 ttcatatatt ttagcatatt cgaactaatt tctaagaaat ttagttataa ctctatgtag 1920 ttatagaaag tgaatatgca gttattctat gagtcgcaca attcttgagt ctctgatacc 1980 tacctattgg ggttaggaga aaagactaga caattactat gtggtcattc tctacaacat 2040 atgttagcac ggcaaagaac cttcaaattg aagactgaga tttttctgta tatatgggtt 2100 ttgtaaagat ggttttacac actacagatg tctatactgt gaaaagtgtt ttcaattctg 2160 aaaaaaagca tacatcatga ttatggcaaa gaggagagaa ggtagagctg ttcttaaatt 2220 tattaaaaaa aaaaaaaaa 2239 <210> 441 <211> 5981 <212> DNA <213> Homo (Homo sapiens) <400> 441 aggttgaagt gagcagagat catgccagcc tgggtgacag tgagactctg tctcaaacag 60 aattaaggaa aaaagaaaga aagaaaaaga gagagaggaa attccaggcc aattgtggca 120 tagattttat catattctgg attttttgga ttcttttgtt ttctcatcac tggattcagg 180 aaagcctgtt gtgtccacca tctccaaagg aggttacctg cagggaaatg ttaacgggag 240 gctgccttcc ctgggcaaca aggagccacc tgggcaggag aaagtgcagc tgaagaggaa 300 agtcacttta ctgaggggag tctccattat cattggcacc atcattggag caggaatctt 360 catctctcct aagggcgtgc tccagaacac gggcagcgtg ggcatgtctc tgaccatctg 420 gacggtgtgt ggggtcctgt cactatttgg agctttgtct tatgctgaat tgggaacaac 480 tataaagaaa tctggaggtc attacacata tattttggaa gtctttggtc cattaccagc 540 ttttgtacga gtctgggtgg aactcctcat aatacgccct gcagctactg ctgtgatatc 600 cctggcattt ggacgctaca ttctggaacc attttttatt caatgtgaaa tccctgaact 660 tgcgatcaag ctcattacag ctgtgggcat aactgtagtg atggtcctaa atagcatgag 720 tgtcagctgg agcgcccgga tccagatttt cttaaccttt tgcaagctca cagcaattct 780 gataattata gtccctggag ttatgcagct aattaaaggt caaacgcaga actttaaaga 840 cgccttttca ggaagagatt caagtattac gcggttgcca ctggcttttt attatggaat 900 gtatgcatat gctggctggt tttacctcaa ctttgttact gaagaagtag aaaaccctga 960 aaaaaccatt ccccttgcaa tatgtatatc catggccatt gtcaccattg gctatgtgct 1020 gacaaatgtg gcctacttta cgaccattaa tgctgaggag ctgctgcttt caaatgcagt 1080 ggcagtgacc ttttctgagc ggctactggg aaatttctca ttagcagttc cgatctttgt 1140 tgccctctcc tgctttggct ccatgaacgg tggtgtgttt gctgtctcca ggttattcta 1200 tgttgcgtct cgagagggtc accttccaga aatcctctcc atgattcatg tccgcaagca 1260 cactcctcta ccagctgtta ttgttttgca ccctttgaca atgataatgc tcttctctgg 1320 agacctcgac agtcttttga atttcctcag ttttgccagg tggcttttta ttgggctggc 1380 agttgctggg ctgatttatc ttcgatacaa atgcccagat atgcatcgtc ctttcaaggt 1440 gccactgttc atcccagctt tgttttcctt cacatgcctc ttcatggttg ccctttccct 1500 ctattcggac ccatttagta cagggattgg cttcgtcatc actctgactg gagtccctgc 1560 gtattatctc tttattatat gggacaagaa acccaggtgg tttagaataa tgtcagagaa 1620 aataaccaga acattacaaa taatactgga agttgtacca gaagaagata agttatgaac 1680 taatggactt gagatcttgg caatctgccc aaggggagac acaaaatagg gatttttact 1740 tcattttctg aaagtctaga gaattacaac tttggtgata aacaaaagga gtcagttatt 1800 tttattcata tattttagca tattcgaact aatttctaag aaatttagtt ataactctat 1860 gtagttatag aaagtgaata tgcagttatt ctatgagtcg cacaattctt gagtctctga 1920 tacctaccta ttggggttag gagaaaagac tagacaatta ctatgtggtc attctctaca 1980 acatatgtta gcacggcaaa gaaccttcaa attgaagact gagatttttc tgtatatatg 2040 ggttttgtaa agatggtttt acacactaca gatgtctata ctgtgaaaag tgttttcaat 2100 tctgaaaaaa agcatacatc atgattatgg caaagaggag agaaagaaat ttattttaca 2160 ttgacattgc attgcttccc cttagatacc aatttagata acaaacactc atgctttaat 2220 ggattatacc cagagcactt tgaacaaagg tcagtgggga ttgttgaata cattaaagaa 2280 gagtttctag gggctactgt ttatgagaca catccaggag ttatgtttaa gtaaaaatcc 2340 ttgagaattt attatgtcag atgttttttc attcattatc aggaagtttt agttatctgt 2400 catttttttt tttcacatca gtttgatcag gaaagtgtat aacacatctt agagcaagag 2460 ttagtttggt attaaatcct cattagaaca accacctgtt tcactaataa cttacccctg 2520 atgagtctat ctaaacatat gcattttaag ccttcaaatt acattatcaa catgagagaa 2580 atcaccaaca aagaagatgt tcaaaataat agtcccatat ctgtaatcat atctacatgc 2640 aatgttagta attctgaagt tttttaaatt tatggctatt tttacacgat gatgaatttt 2700 gacagtttgt gcattttctt tatacatttt atattcttct gttaaaatat ctcttcagat 2760 gaaactgtcc agattaatta ggaaaaggca tatattaaca taaaaattgc aaaagaaatg 2820 tcgctgtaaa taagatttac aactgatgtt tctagaaaat ttccacttct atatctaggc 2880 tttgtcagta atttccacac acacacacac tttttatata tatatatata tatatatata 2940 tagtggaact tacaaatgag agtaatataa tgatgaaatt ttgaactgtt atttataaac 3000 atctaaggta aaatggttag tcatggccag agtatgtttc atcctttaat ttttgtccat 3060 ttgaaaataa ggatttttga aagaattata ccaattaaaa ttattaaagg caaacataga 3120 attcataaaa aattgtccaa agtagaaatg atgacctata atttggagca tttccaattc 3180 agtaatttca attttgctct tgaaaacatt taatatatat ccaagactga catttcttta 3240 gctgaaccta acgtttgggt ctctgagtga atttataata actccttcct tccttagcat 3300 agggttttca aaatttgatt tataattcct atttccagta aatattgttc atttgtccac 3360 atctctccct atgatatgtt gctggaggta agaatttctt tcatattcct attttttttt 3420 tccccataga ctaggctcat agaatttaaa caagcaaatt ttcctgagct ttttcttgcc 3480 aaatgaaaga agactggtaa attctcatag agaggtttgt gtagttcttg gctcttcctg 3540 gggttaatgt gcttatattc acagtggcaa attggtctca gactttaatt tatttatttt 3600 tgatttgaat ttctctttaa aagtatcaat ttaaaaggta actagaatta ttctttctca 3660 ttttcaaaag tgatttttgc attattaaat ttccctgcca ttgtaatgcc atttcacgca 3720 gaaaaaaagt cagccagtaa ttaagaaaaa aagtgatgga gattaagtag tattttggct 3780 tatttttagg actcatcatg agaagacaca gttcctttaa tcaggaaatt aatatccata 3840 attttcactc aaaattgcag tatgtaaagc agattctcaa aaactctcct gaacacttat 3900 ttatatatat gtttttatat aagtaaaatt tttctcatat ttttatacga tatgcacaca 3960 cacacataca tgcacatact acttactaca tgttctgtac ttgtactttg taccatgcat 4020 attcaaatgt ttatatacat aagtttatta taacataaac agtaaaagta atgaatactg 4080 tttaaaataa ctaatatagt attttttaat ttttgtgggg atggattctc aaatacttgt 4140 gattttaaaa gattctaaag ctaaaacaca acttgatttt aaaaagaatg attctcctta 4200 cacaattata aatatttgca gtaaatattt tccttataat actgttttga ccccatttaa 4260 aaagtattag attatattcc tttgatccaa tgaaaactga accttataaa tggttagctg 4320 aaagtagacc ttattcttgt ccttctttag aagagtaaag atttgtccta gggaagatgg 4380 ctgacttcgg ttcccaacat gcgtatgcat ttagactgta gctcctcagc cctgtggaca 4440 caaaatttgg acagcttatt aggttacgtt agcaatgcat gacggtttct ccaacactaa 4500 gatattcacg ttgaaacaga tttcctgttc gtcttatgtg tctggtaaaa ttgtttcccc 4560 aattacaatt tgacatatca atagagggtt aacaagagta taattacata acagaattcc 4620 tcatgaactg taatcagtct acaggaaaat cattatttta tcttgatttg cagatgaata 4680 tactgctaag aaagggagca actctgacct ttgttaaagt tgatcttttg taattgaggt 4740 ataaggtatg aaaagataaa aaaccgaagg ccagagaatc aggaaatgaa agatagtatg 4800 gactgaaggt aacaatattt taatgttatg caatatagcc agagaaatat taaaaattag 4860 ttgtttgctg tgcataggtg gatctcgcag gaagctaatg aaacctaagc ttcagtgcct 4920 ctcacttaga catgttccat tcgaggtcct gaacctaact ttgtattagg aattctgtac 4980 taattttgtt gaagaagacc agcaaagttg tgtacacttc tacccccaca aaatctgcat 5040 tgtccatgtg agtaaagtaa aataattcct gttatttttt tctgttagaa ataagtatgg 5100 aggatatgtt tttaaaaatt tatgagttaa ttgaaatatc catatataac aagtgacttt 5160 ctcacaatat atatgatgtg atatataggg agatagtttc actttcatca tattttatac 5220 gttgattctg aactatagaa aaataataaa tgggatttta attatagctc ttagttggga 5280 aagaaatata gagagatgtg ggatttgaat gcccatgaaa gacattttat tttacttgaa 5340 tatattcttg cttcacttta ccctccataa tatgttgtac attagtgctg atcaagttta 5400 cagagttaca ttttgctttc ctaaccattc agtcaggaat taaaatatgg cattgtataa 5460 caactgggaa gaagctcata gtggatataa attagagtag ataatgggtc accttgatag 5520 cctctgttta cattacttgt atatgggcaa aataattatt acctatacgt gtatttaagc 5580 ttaattttca tataaacagt atttttaatc tatgttaaaa tagataatat ctaaaagtgt 5640 gatctctagg tagtccttag tttattagta ctgtacttca aaaagatttt taaataggtc 5700 cggcacggtg gctcatgcct gtaatcccag cactttggga ggctgaggcg ggcgaatcac 5760 ctgaggtcag gagttcgaga tcagcctggc caacatggtg aaaccctgtc tcaactaaaa 5820 atataaaaat tagccgggcg tggtggcagg cgcctgtaat cccagctact cgggaggctg 5880 aggcaggaga atcacttgaa cccaaggggc agaagctgca gttagccaag atcgcatcat 5940 tgcactccag cctaggggac aagagcgcga gacttcatct c 5981 <210> 442 <211> 337 <212> DNA <213> Homo (Homo sapiens) <400> 442 gatggaggtt gaagtgagca gagatcatgc cagcctgggt gacagtgaga ctctgtctca 60 aacagaatta aggaaaaaag aaagaaagaa aaagagagag aggaaattcc aggccaattg 120 tggcatagat tttatcatat tctggatttt ttggattctt ttgttttctc atcactggat 180 tcaggaaagc ctgttgtgtc caccatctcc aaaggaggtt acctgcaggg aaatgttaac 240 gggaggctgc cttccctggg caacaaggag ccacctgggc aggagaaagt gcagctgaag 300 aggaaagtca ctttactgag gggagtctcc attatca 337 <210> 443 <211> 739 <212> DNA <213> Homo (Homo sapiens) <400> 443 gaattcgaac cccttcggat tctaatcaag aaaatgattt gctatgggaa gagaagtttc 60 ctgaaagaac aactgttact gaattacctc agacttcaca tgtatcattc tccgagcctg 120 atattccgtc ctcaaaaagt actgagttac ctgtggactg gagtattaaa acgcgactcc 180 ttttcacctc ttctcaaccc tttacctggg cagatcattt gaaagcacag gaagaagctc 240 aaggtcttgt ccagcattgt agggcaacag aagttacttt gcctaaaagt atacaggatc 300 ccaaactctc ctctgagctc cgttgtacct tccagcagag ccttatctat tggctccacc 360 ctgctttgtc ttggctacca ctgttccctc gtattggagc tgatagaaaa atggctggaa 420 agacaagtcc ttggtcaaat gatgcaaccc tgcagcatgt tttaatgagt gactggtctg 480 tgagctttac ttctctatat aatttgctga agacaaaact ttgcccctat ttctacgttt 540 gtacctatca gtttactgtc ctgttccgag cagcaggatt agctggaagt gacttaatca 600 cagctctcat atctccaaca actcgaggtt taagagaagc tatgagaaat gaaggtattg 660 aattttctct gcctttaata aaagaaagtg gccataagaa ggagacagca tctggaacaa 720 gcttgggata tggggagga 739 <210> 444 <211> 738 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (738) <223> n = A, T, C or G <400> 444 tttttttttt ttcgttnaaa agaaatttta tttctanant ggaatgattt ggatgtgacc 60 tgataaatac agtttgttat tgnggtctca ttaaattaat cagctttttc acactggggt 120 aaagaaacag atgatgatac tagggaatgg aaacaaaatt ggaaacctgg gttatttggg 180 gatttatatt gtactctgca cagttgccct tttttttagg cgtgttccct ggaaaagagg 240 gacggatgaa cctggaagta agtaaaagac attctaggtg tgtagcatca aggcagttaa 300 tatccaagca tcagctttct ctttatacat ctacactgca tggcctgcac caaataagga 360 actgaaccag gggtatgttt ttacctccac agctgcctcc ttccatcana gcaccttgat 420 gaacttaatg tctagtcaca cgtcattggc atgttttctc cccagcattt aattacaaag 480 ctttctttct ttggatagga tcagttctta agagcagccc cggtaactgg aggaatggga 540 gccgttttga tganaaaaat gggtttggtg ttcaggatct ccaattataa atgtagtctc 600 tcagcaccac attccgtaaa gatgatttcc caagtaacggtatttgacta agttgctcca 660 gagtgttagg ggcaaaccac agttagtaag ctccttatga acaaccccca tatcaagtac 720 tttgtccatt tgcaggca 738 <210> 445 <211> 716 <212> DNA <213> Homo (Homo sapiens) <400> 445 gcggccgcta gtgctccagc tcgcgctccg ccctcaggca cagcatcccc acgggcctcc 60 acgccaacct gtccgagggc cgccccgtgg gtccggcccg ccgtggcgcc tcatcgctgc 120 tcggcccgga aggcttcttc cttggcaaga tgggattccg ggaggcggtg gcggccggag 180 acgtggattt gcctcaggtg cggagccgca gctacaggag gatgctcgcg aggaccccca 240 gagctccgcc cggagggtac tgtgaggccg ttaggagctg gcggtggatg acttccgcat 300 tcaaacactg gagccatcac acggaagcac gaggagggta tcctcggcag ctactcccgg 360 tcgctcaagg tgtctctcgc tcgccctcta ggtgcgggag gagctcgagg cccaactaag 420 ctgcttccgg gagctgctgg gcagggcccc cacgcacgcg gacgggcacc agcacgtgca 480 cgtgctccca ggtggacaga cgccttcgtg ggcctgagca cttgcggccg gcacatgtcc 540 gctcaccgcg tgtccggggc cctggcgcgg gtcctggaag gtaccctagc gggccacacc 600 ctgacagccg agctgatggc gcaccccggc taccccagtg tgcctcccac cggcggctgc 660 ggtgaaggcc ccgacgcttt ctctttgctc ttgggaagcg gcttgcattg agcttg 716 <210> 446 <211> 641 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (641) <223> n = A, T, C or G <400> 446 gctncagctc gcgctccgcc ctcaggcaca gcatccccac gggcctccac gccaacctgt 60 ccgaggnccg ccccgtgggt ccggcccgcc gtggcgcctc atcgctgctc ggcccggaag 120 gcttnttcct tggcaagatg ggattccggg aggcggnggc ggccggagac gtggatttgc 180 ctcaggtgcg gagccgcagc tacaggagga tgctcgcgag gacccccaga gctccgcccg 240 gagggtactg tgaggccgtt aggagctggc ggnggatgac ttccgcattc aaacactgga 300 gccatcacac ggaagcacga ggagggtatc ctcggcagct actcccggtc gctcaaggtg 360 tctntcgctc gccctctagg ngcgggagga gctcgaggcc caactaanct gcttccggga 420 gctgctgggc agggccccca cgcacgcgga cgggcaccag cacgtgcacg tgctcccagg 480 nggacagacg ccttcgtggg cctgancact tgcggccggn acatgttccc tcacccgcgg 540 gtccgggccc ttggcgcggg tcctggaagg taccctacgg gccacaccct gacagccgaa 600 ctgatggccc accccggcta ccccangtgt gcctccaccc g 641 <210> 447 <211> 652 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (652) <223> n = A, T, C or G <400> 447 gaattcgaac cccttcgctt ttagaaaatt gtatatgcag ctggatgaag gcagcctcac 60 ctttaatgcc aacccagatg agggagtgaa ctactttatg tccaagggta tcctggatga 120 ttcgccaaag gaaatagcaa agtttatctt ctgtacaaga acactaaatt ggaaaaaact 180 gagaatctat cttgatgaaa ggagagatgt cttggatgac cttgtaacat tgcataattt 240 tagaaatcag ttcttgccaa atgcactgag agaatttttt cgtcatatcc atgcccctga 300 agagcgtgga gagtatcttg aaactcttat aacaaagttc tcacatagat tctgtgcttg 360 caaccctgat ttaatgcgag aacttggcct tagtcctgat gctgtctatg tactgtgcta 420 ctctttgatt ctactttcca ttgacctcac tagccctcat gtgaagaata aaatgtcaaa 480 aagggaattt attcgaaata ccccgcgcgc tgctcaaaat attagtgaag aattttgtan 540 ggcatcttta tgacaatatc tacccttatt gggccatggn ggctggcata aaaaagcacc 600 aattggctaa ggactttcaa gttttttact ttcagaactt aaaagcttac cc 652 <210> 448 <211> 677 <212> DNA <213> Homo (Homo sapiens) <400> 448 gaattcgaac cccttcggcg cctggcagag gtgaaggact ccctggacat cgaggtcaag 60 cagaacttca ttgaccccct ccagaacctg tgcgagaaag acctgaagga gatccagcac 120 cacctgaaga aactggaggg ccgccgcctg gactttgact acaagaagaa gcggcagggc 180 aagatccccg atgaggagct acgccaggcg ctggagaagt tcgaggagtc caaggaggtg 240 gcagaaacca gcatgcacaa cctcctggag actgacatcg agcaggtgag tcagctctcg 300 gccctggtgg atgcacagct ggactaccac cggcaggccg tgcagatcct ggacgagctg 360 gcggagaagc tcaagcgcag gatgcgggaa gcttcctcac gccctaagcg ggagtataag 420 ccgaagcccc gggagccctt tgaccttgga gagcctgagc agtccaacgg gggcttcccc 480 tgcaccacag cccccaagat cgcagcttca tcgtctttcc gatcttccga caagcccatc 540 cggaccccta gccggagcat gccgcccctg gaccagccga gctgcaaggc gctgtacgac 600 ttcgagcccg agaacgacgg ggagctgggc ttcatgaggg cgacgtcatc acgctgacca 660 accagatcga tgagaac 677 <210> 449 <211> 603 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (603) <223> n = A, T, C or G <400> 449 ttttttgtan aaagagacat ttaatacttc tgtttacaaa attcaggcgt acatttcagt 60 ttgccctgga ccgtgcccaa agctgtgtgc tcatctctgc gcccctcatg tacttctgac 120 gaggggggtg cagggcaggg cagagcagag cctggggtcc ggaggcttca ctggaccaca 180 gggggagggg aatgtgaatg tggcctggcc canagaactc cccatttcat cgattttgca 240 ttgggcgata gaggaagcag atgtcggggc tgcctgcctt ggtctanagg agatggctgg 300 ggccacttcc cacagggtga agtggcagcg gctcagcaag gggagcctgg ccaccagggg 360 ctgggacatg cgctcactgg aacctttgtg cttggccctc ggcagcgcgg ctgtggtccc 420 gtgtgaggtg tgctggggtg gggtgtgggt ggctggtggt ggcagcttgt gccagagtga 480 cacaggcctc cctgggttgg gatgggggca agttaaaaag ctgaaaaggt acttggcttt 540 ctgagggcgg gcttgggagc aggccctgca gganaccatg ttctctgtcc tcagcagatc 600 cac 603 <210> 450 <211> 678 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (678) <223> n = A, T, C or G <400> 450 gaattcgaac cccttcgcat caatataana tgccacccat ctgcagttaa tttcttttcc 60 tcatcatgtg attaaaagtg gtgattcagt gggaactggg aatgttttta gctggtggta 120 gaaggctgcc tacactgggc actgttttag attctcatat catttaaaca gcaaggaggt 180 tcagggaaga ataaccgtag ccttgggtaa tccactaggg cttttgtgag taggagagct 240 gatacctcac attcttagca ggtgaaaact tgccatgatg gaaacagata gtgaagagtt 300 actgacgtat cccaaattat atgctgtgac ataaattccc agcatgccca gccctgattt 360 ctgagttcat aagtaattct agtgaacctt agtaggaatt ctgggtaaga aaatgaggtt 420 gccattggtc ttgtttgcat caccaagacc agacatccag aagagcccct caccttgaaa 480 agcagacaga ttttaaatta accccctcct tcccactcac cttcatctcc ctaagagttt 540 tggccattta attccacatt ttgaaaggaa tacattggtg aaatttggga agagaatctg 600 tgctatgcaa tgtttcatta aaatcttcag tttttcaagt ctctctaaaa ataatttgta 660 gatctatctt ggatggat 678 <210> 451 <211> 651 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (651) <223> n = A, T, C or G <400> 451 tttttcatca acaaaaatca agcattttcn tttttttgaa acaagaaaag cgcatcgtan 60 aaaccaagat tctgtacaat attctaacat tatatgtaca taaaattata ttactcataa 120 ctatattgaa aagtcttatt tgtagaatat ggctggcaac aaagaaagac ccataccatt 180 tagcgtttga agcagggcag gtagcaagag aacattagca aagacacctt tgtgcctgga 240 tacacaatcc tgctactaag ttatgtgact aaccagcaca ctctaagttc tgtggtttgt 300 tcgttgtttc acattctagt agggaattct gcagcaggcg atgcgaaaaa naanacatgg 360 tcaaatgaaa tgtgaaatgc tgtttaaaat ctgcatattg gctatgataa tgggtttgng 420 aatccaagtt gcattggaag ttcactcatt ctccattcat tatgcatgcc tccagtgatt 480 taatgaattt cagcaggngg aaaagacagc tttgaacaga tcagatgggc tgtgagtcan 540 attcttgatt ctttttcctc atttggctcc tgaatgttgc anaaaactgg ttttgtacac 600 tggggaagga gagagtgaag accctccagt tggttcctca gtcagctccg t 651 <210> 452 <211> 679 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (679) <223> n = A, T, C or G <400> 452 gaattcgaac cccttcgcat tgctcagccn nctaccactg ctaagagcca tctccaccag 60 aagcctggcc agacctggaa gaacaaagag catcatctct ctgacagaga gtttgtgttc 120 aaagaacctc agcaggtagt acgtagagct cctgagccac gagtgattga cagagagggt 180 gtgtatgaaa tcagcctgtc acccacaggt gtatctaggg tctgtttgta tcctggcttt 240 gttgacgtga aagaagctga ctggatattg gaacagcttt gtcaagatgt tccctggaaa 300 cagaggaccg gcatcagaga ggatataact tatcagcaac caagacttac agcatggtat 360 ggagaacttc cttacactta ttcaagaatc actatggaac caaatcctca ctggcaccct 420 gtgctgcgca cactaaagaa ccgcattgaa gagaacactg gccacacctt caactcctta 480 ctctgcaatc tttatcgcaa tgagaaggac agcgtggact ggcacagtga tgatgaaccc 540 tcactaggga ggtgccccat tattgcttca ctaagttttg gtgccacacg cacatttgag 600 atgagaaaga agccaccacc agaagagaat ggagactaca catatgtgga aagagtgaag 660 atacccttgg atcatggta 679 <210> 453 <211> 630 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (630) <223> n = A, T, C or G <400> 453 gaattcgaac cccttcggaa ggccaagggn ntagaaggng gctccggccc cagctgtcgt 60 gaagaagcag gaggctaaga aagtggtgaa tcccctgttt gagaaaaggc ctaagaattt 120 tggcattgga caggacatcc agcccaaaag agacctcacc cgctttgtga aatggccccg 180 ctatatcagg ttgcagcggc agagagccat cctctataag cggctgaaag tgcctcctgc 240 gattaaccag ttcacccagg ccctggaccg ccaaacagct actcagctgc ttaagctggc 300 ccacaagtac agaccagaga caaagcaaga gaagaagcag agactgttgg cccgggccga 360 gaagaaggct gctggcaaag gggacgtccc aacgaagaga ccacctgtcc ttcgagcagg 420 agttaacacc cgtcaccacc ttggtggaga acaagaaagc tcagctggtg gtgattgcac 480 acgacgtgga tcccatcgag ctggttgtct tcttgcctgc cctgtgtcgt aaaatggggg 540 tcccttactg cattatcaag ggaaaggcaa gactgggacg tctagtccac aggaagacct 600 gcaccactgt cgccttccac aggtgaactc 630 <210> 454 <211> 677 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (677) <223> n = A, T, C or G <400> 454 gaattcgaac cccttcgccc gcatgcggna catccccttg gccccagggt cagactggcg 60 cgatctgccc aacatcgagg tgcggctctc agacggcacc atggccagga agctgcggta 120 tacccaccat gacaggaaga acggccgcag cagctctggg gccctccgtg gggtctgctc 180 ctgcgtggaa gccggcaaag cctgcgaccc cgcagccagg cagttcaaca ccctcatccc 240 ctggtgcctg ccccacaccg ggaaccggca caaccactgg gctggcctct atggaaggct 300 cgagtgggac ggcttcttca gcacaaccgt caccaacccc gagcccatgg gcaagcaggg 360 ccgcgtgctc cacccagagc agcaccgtgt ggtgagcgtg cgggagtgtg cccgctccca 420 gggcttccct gacacctacc ggctcttcgg caacatcctg gacaagcacc ggcaggtggg 480 caatgccgtg ccaccgcccc tggcaaagcc attggcttgg agatcaagct ttgtattgtt 540 ggccaaagcc cgagagagtg cctcagctaa aataaaggag gaggaagctg ctaaggacta 600 gttctgcctt cccgtcaccc ctgtttctgg caccaggaat cccccacaat gcacttgatg 660 gtggggtttt aacatgt 677 <210> 455 <211> 598 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (598) <223> n = A, T, C or G <400> 455 ttttttggtt tataggagag atttatttga agaaatatta caacatataa aaactacata 60 aagtcttaat ttccactcat acagtggtag atttgatata atgcataata aaaaactttt 120 aaaatccaga atgcacaaag tactgcacaa tttgatcact aaatcattag ttgataagcg 180 aacctcacac aacagcttca tgtcagccaa ggccacaaac accatgtacc acacatgtga 240 acggacagat tgacatgtta aaaacacaac atcagtgcat gttggggatt cctggtgcca 300 gaaacagggg tgacgggagg gcagaactag tccttagcag cttcctcctc ctttatttta 360 gctgaggcac tctctcgggc tttggccaac atacaaagct tgatctccaa gccaatggct 420 ttggccaggg gcggtggcac ggcattgccc acctgccggt gcttngtcca ggatgttgcc 480 cgaagagccg gtaggtggtc aagggaagcc cctggggaag cgggcacact cccggacgct 540 naccacacgg tgctgntttt gggtggagca ccgcggcctt gcttgcccat gggctcgg 598 <210> 456 <211> 574 <212> DNA <213> Homo (Homo sapiens) <400> 456 ggaattcgaa ccccttcggg gcggggagcc ccgtagaacc gagggggtcg gcccgggggt 60 cccgggggag gtggagatgg tgaaggggca gccgttcgac gtgggcccgc gctacacgca 120 gttgcagtac atcggcgagg gcgcgtacgg catggtcagc tcggcctatg accacgtgcg 180 caagactcgc gtggccatca agaagatcag ccccttcgaa catcagacct actgccagcg 240 cacgctccgg gagatccaga tcctgctgcg cttccgccat gagaatgtca tcggcatccg 300 agacattctg cgggcgtcca ccctggaagc catgagagat gtctacattg tgcaggacct 360 gatggagact gacctgtaca agttgctgaa aagccagcag ctgagcaatg accatatctg 420 ctacttcctc taccagatcc tgcggggcct caagtacatc cactccgcca acgtgctcca 480 ccgagatcta aagccctcca acctgcttca tcaacaccac ctggcgacct ttaaaatttg 540 tgaatttccg gcctggcccc cggattgccc gaat 574 <210> 457 <211> 546 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (546) <223> n = A, T, C or G <400> 457 ttttttgaca catctctata tttatatatt agacgggtca gggaggtggc aggggcgccg 60 ggctctccac gccccccagc tccacttctg ctcaccacac acagaagcag cgagggcacg 120 cgaagtgaca gctttgacag ggaggggatt cggcccggcc tggctcctca gggatgctag 180 cccttgagac taaggaatgt tccttcaggg aaactagggt ggggtttgaa tganatgagg 240 ggggcaggca tggccctgag tccctactca gcgcccccca ccctccacct ctgcccttca 300 gcaggttggg gcagccagaa cccttccatt ccagaactgc cagagactgg gacgctgggg 360 aaggtaaggg cgcagcagca gcagcgggag attgaactgg ggccacctga gctcccgagg 420 ccccgtgggg agggcgggtg gggaggaaaa ggccttggcc tgcctgaagc tggaggcctc 480 agcaaaggag agaggtggcc aggcccatgc tccaccccgg cctgggctgc caanggtccc 540 gggctg 546 <210> 458 <211> 674 <212> DNA <213> Homo (Homo sapiens) <400> 458 gaattcgaac cccttcggta ttattaagaa ctaagagaat agcttgccag atacaaatgg 60 aaacaccttc caaatgagtc ggagaaaatg tcttgcagta ttatgggtaa aatagcaaag 120 agcttgggaa tacagtttgc taatatcaag tccttaacaa cgaccattct tcattcaaga 180 ttagttgtgt ataaatacat gcttcttcag gagttgactt agaaaacaag caaacaaaca 240 aacatcagaa actatttaca actgggagca atccttgaag aacataaaga atataaatat 300 caacaaaggc tgaaaactct tttttagatt aaagatcaaa tggacatgtc atcggaatgt 360 attgtatggc tcttgattaa atcctggagc aaagtggaga gtgaggaaca actgtaaaga 420 atgtgaatac ggactgtgta ttagataaca gtaccataaa tttcctggat gggataatta 480 tgttgtgact atgtaagaga atattttgcc cttagaagat atatgatgaa gcatttagaa 540 gtaaagtatc atgacatctt gcaaataact ttcaagtgat tcagccagat atataaaaat 600 tatatataac acattatata atttatattt atataattat aatacattat ataatttata 660 cattataatt atat 674 <210> 459 <211> 682 <212> DNA <213> Homo (Homo sapiens) <400> 459 tttttttaaa tccatggctt gttaattgtc atcccagtta tttacatgtg actatagaga 60 ctgcattctc ccagctgcca ggccgccagg gctttgccac tggtataatt tataacacga 120 ctaattaaaa tgaatttgct tgcaataagg ttctgtgtgc tatttgtggg agaggagtta 180 ttaaaatttt cagtacagta atagtaaact tgaatgcaaa gtaataataa tcatacattt 240 ttaattacat gtttaatacc catttggcta atgtagaact attctgaaaa ttacttggga 300 tcagcacaat gtctttttgt gcttagtagt atccaaagac atccttctga atgggcttag 360 caatatgcac tgtcatcaag atacagctgt ttgatgacag acacacagtg tgttcctatg 420 atactttgca caagatcagc tatgacaaat acaagttcat tttgcttatt gcaggcaaat 480 aatgtccttt gcaggaactt ggatggagcc agaggccatt attctaagtg aaatacctca 540 ggagtggaaa accaaatacc atatgttctc acttacaagt gggaactaag ctatgggtac 600 acaaacgcat atagagtaat ggactctggc gactcatact acatattgag tacaatgtac 660 actacttggg tgatgggtgc ac 682 <210> 460 <211> 663 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (663) <223> n = A, T, C or G <400> 460 gaattcgaac cccttcgcgg ggcgcgcgag cggcgccagc tcggggcagc ggaacccaga 60 gaagctgagg gggcggtagc ggcggcgacg gcgacgacga cgactcccgc gcgtgtgccc 120 agcctcttcc cgccgcagcc gcccttttcc tccctccctt acgtccccga gtgcggcagt 180 accgcctcct tcccagccgc gcggcttcct ccagacctct cggcgcgggt gagccctatt 240 cccagaggca ggtggtgctg accctgtaac ccaaaggagg aaacagctgg ctaagctcat 300 cattgttact ggtgggcacc atgtccttga agcttcaggc aagcaatgta accaacaaga 360 atgaccccaa gtccatcaac tctcgagtct tcattggaaa cctcaacaca gctctggtga 420 agaaatcaga tgtggagacc atcttctcta agtatggccg tgtggccggc tgttctgtgc 480 acaagggcta tgcctttgtt cagtactcca atgagcgcca tgcccgggca gctgtgctgg 540 gagagaatgg gcgggtgctg gccgggcaga ccctggacat caacatggct ggagagccta 600 agcctgacag acccaagggg ctaaaganaa gcagcatctg gcatatacag gctcttcgac 660 tac 663 <210> 461 <211> 612 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (612) <223> n = A, T, C or G <400> 461 ttttttggga tccaatctnt ttattgtcag ggtcccctcc ctgnggcccc ccgccaaacc 60 tatagaaaaa acccaagcct gggagtgtcc tggggagggg aggtagtatg gggaaacccc 120 tgtgctctac cctntggcct gggcagtgca nacagggagg gctcatgggg aaggagtagg 180 ccagtaactc cacctgcana ggacatggca ctggctggga tgcgttgggg gaggaggcgc 240 ctgctgccag ctttcctntg gtacccgctg gggggtggca tccagggttg ggtgcccggc 300 ttgaggcctg gggcagcgat gcccttcacc tgctggnggc cattgctcct gtcaggctgc 360 ttactgcaag gccccatcat ccgcgtctgt gtcctggctg tgttccagct cttcctcgct 420 gngtgtcagg agcccttcct catcgccgtc gtctcgggtc cgtgcttccc cctggggcag 480 gcctgcctca naagttgtgt tctcttgggg ggctggtggc cggttgttgc caccgcaccg 540 caccaccact ggcaccggca ccgntgcacc accaccgccg ccgccgccgn tggngccacc 600 ttcatcaccc tt 612 <210> 462 <211> 672 <212> DNA <213> Homo (Homo sapiens) <400> 462 gaattcgaac cccttcggat ggaaggggcc ggggcagcgt cggggaaagg aagggccgga 60 ggcgcggcgg cgggcggccg agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc 120 gcggagcccg gcccgagagc cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg 180 cgccgccatg acgcccgatc tgctcaactt cagccccaga tgtcaccaag ctctcggact 240 ctaacaagga gaacgcgctg cacagctaca gcacccagaa gggccccctg aaggcagggg 300 agcagcgggc gggctctgag gtcatcagcc ggggtggccc tcggaaggcg gacgggcagc 360 gtcaggcctt ggactacgtg gagctctcgc cgctgaccca ggcttccccg cagcgggccc 420 gcaccccagc ccgcactcct gaccgccctg gccaagcagg aggagctgga gcgggacctg 480 gcccagcgct ccgaggagcg gcgcaagtgg tttgaggcca cagacagcag gaccccagag 540 gtgcctgctg gtgaggggcc gcgccggggc ctgggtgccc cctgactgag gaccagcaaa 600 accggcttag tgaggagatc gagaagaagt ggcaggagct ggagaagctt gcccttgcgg 660 gagaataacc gg 672 <210> 463 <211> 562 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (562) <223> n = A, T, C or G <400> 463 ttttttaaag tataaagtgt tttggaaaaa aaggaaaaan ntctatataa aaatctcttc 60 acatataaaa tcctgaagaa ggtgcaaggt gagacccagt gcgaggggcg tgctcagata 120 tgcagtgtgt gtgtgtgtgt gtgtgtgtgt gtatccgtgt gtacatgtgt gcacgtgtgt 180 gcgtatgtgt ctgtgtgtct gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt ggtgggtgca 240 agtgcacgtg tggcccacag agggtgggga gaaagcttgg ctttttactt ccatccagga 300 gggaaggagg gcggctggtc ctccagcctg gagggtctgc agctgggcgg gacctctact 360 cagccaggct gttgcgcatc gactccttct cctggagggc ggccatggca agacgcaggt 420 gctccttcag ctgctcgatc tcccgctcag accgtgtctt gatgtggctc aactccacat 480 agacgtcctg gtactttccc naggtgaagc gcttgtcctt ctgcatcatc tggagctcgt 540 cccggaggca ctgcaccttc ct 562 <210> 464 <211> 553 <212> DNA <213> Homo (Homo sapiens) <400> 464 gaattcgaac cccttcggga ccaggaaccc aggagagcat ggccacgctg cgccggcttc 60 gggaggcgcc gcggcactta ctggtttgcg agaaatccaa cttcggcaac cacaagtcgc 120 gccaccggca tcttgtgcag acgcactact ataactacag ggtttcattt ctcattcctg 180 aatgtgggat actatcggaa gaactgaaaa acctggtcat gaacactgga ccctattact 240 ttgtgaagaa tttacctctt catgaattaa ttacacctga attcatcagt acctttataa 300 agaaaggttc ttgctatgca ctaacataca atacacatat tgatgaagat aatactgttg 360 ccctgctacc aaatgggaaa ttaattttgt cactggataa agacacttat gaagaaactg 420 gacttcaggg tcatccatct cagttttctg gcagaaaaat tatgaaattt agttcagaag 480 aatcgacaat gatgtcatat ttttccaagt accaaattca ggagcatcag ccaaaagtag 540 cactgagccc gtt 553 <210> 465 <211> 383 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (383) <223> n = A, T, C or G <400> 465 tttttggaag aaaacacgat ttttaatttt tattttttat gggggacagn gatcatttgc 60 cccaacagcc atntgaagcc aatagtcctg attattaaaa atcacaaagt tatataaatg 120 ntctcctcct tttcgaaaac catgttcatt tttttcccaa naaacagggc tgtctgcaaa 180 gccttgaacg gacagngtaa cccatggagc taacttcggt tcatcaaagt agngacagan 240 atgttccaat agganacaga tcttntntgg aagtatgaag ccagngattg tacacaaata 300 agcttttgcc accactgtgc ttggctcagg acagcaatag gttgatatga aattattagg 360 ctcattattt aggncgacat tac 383 <210> 466 <211> 673 <212> DNA <213> Homo (Homo sapiens) <400> 466 gaattcgaac cccttcgctc cctcctgcac gcaatggtgg cctatgatcc cgatgagaga 60 atcgccgccc accaggccct gcagcacccc tacttccaag aacagaggaa aacagagaag 120 cgggctctgg gcagccacag aaaagctggc tttccggagc accctgtggc accggaacca 180 ctcagtaaca gctgccagat ttccaaggag ggcagaaagc agaaacagtc cctaaagcaa 240 gaggaggacc gtcccaagag acgaggaccg gcctatgtca tggaactgcc caaactaaag 300 ctttcgggag tggtcagact gtcgtcttac tccagcccca cgctgcagtc cgtgcttgga 360 tctggaacaa atggaagagt gccggtgctg agacccttga agtgcatccc tgcgagcaag 420 aaggtagcgc ggaaccagct tctctgacgg cgctgctctt cgacccagcc caggccgcca 480 ctgaattttg tgtctgtaat ttttctttga cagacagatc cgcagaagga ccttaagcct 540 gccccgcagc agtgtcgcct gcccaccata gtgcggaaag gcggaagata actgagcagc 600 accgtcgtct cgacttcgga ggcaacacca agcccgaccg ggccaggcct gggtgatctg 660 ctgctgagac gcc 673 <210> 467 <211> 373 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (373) <223> n = A, T, C or G <400> 467 tttttactgg aacgacagct tattntttaa taaaagtcag gggngtcagc agngtcactg 60 gtaanacatg atggcgctcc acgactgacc agcagcgctg ggaagggaca cgcanaaccc 120 accttccaac cacgcccaac acatnacana aatgcctgct cgtttgtttt gattcatata 180 caaagttaca aagtatttcc tgccccaaat tnttaacgaa aatgaaagaa aaccctanaa 240 tgcgggggtt ttacaagtat attagcccan aacatcctag gcagctgcnc gggccgcggg 300 tgcggcaggg cgcagggcaa cacccaaagc cccggccagc gcgaaacgga cgcaggcgca 360 tccccagccc tcc 373 <210> 468 <211> 573 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (573) <223> n = A, T, C or G <400> 468 gaattcgaac cccttcgctg ctgtcctact tgatgcttgt cactgtcatg atgtggcccc 60 tngctgtgta ccaccgactg tgggatcgag catatgtgcg gctgaagcca gctctgcagc 120 ggctagactt cagtgtccgt ggctacatga tgtccaagca gagagagaga caattacgcc 180 gcagagctct ccacccagaa cgagccatgg acaaccacag tgacagcgaa gaggagcttg 240 ctgccttctg tcctcagctg gacgattcta ctgttgccag ggaattggcc atcacagact 300 ctgagcactc agacgctgaa gtctcctgta cagacaatgg cacattcaat ctttcaaggg 360 gccaaacacc tctaacggaa ggctctgaag acctagatgg tcacagtgat ccagaggaat 420 cctttgccag agaccttcca gacttccctt ccattaatat ggatcctgct ggcctggatg 480 atgangacga cactagcatt ggcatgccca gcttgatgta ccgttctccg ccagggggct 540 gaggagcccc aaggccccac ctgccagccc ggg 573 <210> 469 <211> 635 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (635) <223> n = A, T, C or G <400> 469 tcncgatcta gaactaggtt ggacaggctt gctcaagttt caccagagtt antactggcc 60 tctgttcgca gagtttttag ttnnacactg cagaattggc agactacacg gtttatggaa 120 gttgaagtag caataagatt gctgtatatg ttggcagaag ctcttccagt atctcatggt 180 gctcacttct caggtgatgt ttcaaaagct agtgctttgc aggatatgat gcgaactgta 240 agtatactgg agataatttt gaccataaat ttctgttttc agtataagct aatgggagtt 300 ccttaattgt tagagcttag tatatgttaa taccggggca ttttgatgtt gcaataaata 360 agaagaggtt tcctaacttt ttcctgatct agctggtaac atcaggagtc agttcctatc 420 agcatacatc tgtgacattg gagttcttcg aaactgttgt tagatatgaa aagtttttca 480 cagttgaacc tcagcacatt ccatgtgtac taatggcttt cttagatcac agaggtctgc 540 ggcattccag ngcaaaagtt cggagcagga cggcttacct gttttctaga tttgtcaaat 600 ctctcaataa gcaaatgaat cctttccttg aggat 635 <210> 470 <211> 593 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (593) <223> n = A, T, C or G <400> 470 gaattcgaac ccttcggtat taacaaatat ntacatttct atttttataa tccataagga 60 tatgcctgtt ttaaataaca tacatattaa caatatctat caggaaaacc ctcaagacag 120 cttctagtta aaaccttngn tgctgtcctc tcaaactata tttataaaaa tttgctaggg 180 ccaaatccat acttgcagaa taattcatca aattttattt ttaagngaaa agtaaccttt 240 caggcatttc agcagcatac attgacaatc tagggtatat atgtatgtat gtttcttatt 300 gtatgtctat atatgtatgt ggggaggaca ggagtgaatg ttcacacact tttcttgcgt 360 actcaactaa attggagaat gtttctgaag aaaattggat gaaattagct gctgagattg 420 agtttctgcc ttaaaatctg aaacaaaaaa agggacaaat tgctggtang atctactgac 480 tgtngccatc accagaacac ttagtttctt cccagacatg aatttcctga caggctctga 540 gccagaaaca cactgtgggc gtgcatntgg gtcaccctgg atatgcctcc act 593 <210> 471 <211> 581 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (581) <223> n = A, T, C or G <400> 471 tttttttaat cangggacat ttattaacat gcttcaaaag tgaccaaagt gtccagccag 60 cacaatagcc gaggcaatca acgttctctt agtgtgtgat ctcgtccaaa acaccaaata 120 aataggttta ggaataacct caaataaatt gtaatttaac ttcgcccaaa attatacatc 180 ctctactgct cttccctgct cctgtaaaga tactagcggg aggggagaaa gctcaaatga 240 ctctgtaatt tagaattaca accagagaag aaatacttca agcacaataa agacgttcca 300 ttgaagagcg acattcattc tggaatgttt gttttgaaaa caactcttnt gggggaattc 360 aaaaggtact gaacaaagca acataaagta agttttgggt tgttttgcaa aataaaaata 420 tacaattgag tggaccagat ggcaaaaaca taccaattac aatctgaatg ctatatttaa 480 aacccttaaa ttctgaaggc ctgaatatca acaaacctat ttatgtttat gatcctaaaa 540 agacattaaa tattattaaa cccccaactt ccaaaacata g 581 <210> 472 <211> 674 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (674) <223> n = A, T, C or G <400> 472 gaattcgaac cccttcggat ggcgtgatgt ntcacagaaa gttctccgct cccagacatg 60 ggtccctcgg cttcctgcct cggaagcgca gcagcaggca tcgtgggaag gtgaagagct 120 tccctaagga tgacccgtcc aagccggtcc acctcacagc cttcctggga tacaaggctg 180 gcatgactca catcgtgcgg gaagtcgaca ggccgggatc caaggtgaac aagaaggagg 240 tggtggaggc tgtgaccatt gtagagacac cacccatggt ggttgtgggc attgtgggct 300 acgtggaaac ccctcgaggc ctccggacct tcaagactgt ctttgctgag cacatcagtg 360 atgaatgcaa gaggcgtttc tataagaatt ggcataaatc taagaagaag gcctttacca 420 agtactgcaa gaaatggcag gatgaggatg gcaagaagca gctggagaag gacttcagca 480 gcatgaagaa gtactgccaa gtcatccgtg tcattgccca cacccagatg cgcctgcttc 540 ctctgcgcca gaagaagccc acctgatgga gatccaggtg aacggaggca ctgtggccga 600 gaagctggac tgggccccgc gagangcttg agcacaggta cctgtgaacc aagtgtttgg 660 gcaggatgaa aatg 674 <210> 473 <211> 646 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (646) <223> n = A, T, C or G <400> 473 ttttttcagn ggaaaataac ttttattgan accccaccaa ctgcaaaatc tgttcctggc 60 attaagctcc ttnttccttt gcaattcggt ctttcttcag nggtcccatg aatgctttct 120 tctcctccat ggtctggaag cggccatggc caaacttgga ggnggtgtca atgaacttaa 180 ggtcaatctt ctccanagcc cgccgnttcg tctgcaccag caaggacttg cggagggtga 240 gcacccgctt cttggttccc accacacagc ctttcagcat gacaaagtca ttggtcactt 300 caccatagng gacaaagcca cccanagggt tgatgctctt gtcanatagg tcatagtcag 360 tggaggcatt gttcttgatc agcttgccgt ccttgataag gtagccctgg ccaatcttat 420 aaatcttctt gttgatctca gtgcggtgat ggtagccttt ctgcccagcg cgtgccacag 480 agaaggctac acgagcagga tgccatgccc caatacaggc caccttgcgc aggcctcggt 540 gggtcttgcg gggcagcttc ttggtgtgcc aacgactggt gacccctttg tagcctttgc 600 ccttggtcac cccgatgacg tcgatcatct catcctgccc aaacac 646 <210> 474 <211> 544 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (544) <223> n = A, T, C or G <400> 474 gaattcgaac cccttcggca gcacactccc antcggccgc agcctgacac gccgcgcggc 60 cccccagtct cccgcggctg ctcccccagg catggcacag ggcctcgcct cactatggca 120 gcagcacggc acagcacgct cgacttcatg ctcggcgcca aagctgatgg tgagaccatt 180 ctaaaaggcc tccagtccat tttccaggag caggggatgg cggagtcggt gcacacctgg 240 caggaccatg gctatttagc aacctacaca aacaagaacg gcagctttgc caatttgaga 300 atttacccac atggattggt gttgctggac cttcagagtt atgatggtga tgcgcaaggc 360 aaagaagaga tcgacagtat tttgaacaaa gtagaggaaa gaatgaaaga attgagtcag 420 gacaagtact gggcgggtga aacgattacc acccatagtg cgaggaggag ccatcgacag 480 atactggccc accgncgacg ggcgccttgg ttgaatatga catagaatga agtggtatat 540 gacg 544 <210> 475 <211> 578 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (578) <223> n = A, T, C or G <400> 475 gaattcgaac cccttcggga gaaccccatg ngggaacttc gcatccgcaa actctgtctc 60 aacatctgtg ttggggagag tggagacaga ctgacgcgag cagccaaggt gttggagcag 120 ctcacagggc agacccctgt gttttccaaa gctagataca ctgtcagatc ctttggcatc 180 cggagaaatg aaaagattgc tgtccactgc acagttcgag gggccaaggc agaagaaatc 240 ttggagaagg gtctaaaggt gcgggagtat gagttaagaa aaaacaactt ctcagatact 300 ggaaactttg gttttgggat ccaggaacac atcgatctgg gtatcaaata tgacccaagc 360 attggtatct acggcctgga cttctatgtg gtgctgggta ggccaggttt cagcatcgca 420 gacaagaagc gcaggacagg ctgcattggg gccaaacaca gaatcagcaa agaggaggcc 480 atgcgctggt tccagcagaa gtatgatggg atcatccttc ctggcaaata aattcccgtt 540 tctatccaaa agagcaataa aaagttttca gtgaaaaa 578 <210> 476 <211> 619 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (619) <223> n = A, T, C or G <400> 476 ggaattcgaa ccccttcgct cctgcctgtc cgccatgttt tcaggncggg nctggcttgg 60 tcttcccccg taaggaaatg gccggggagc tccaggggac ccaggcgccg tcgcttcggc 120 ggagcctggg ctgaccagcc aggacagcgg ggtaaacccg aacaattctg cgcgaggtag 180 ggaggccatg gcgtccggca gtaactggct ctccggggtg aatgtcgtgc tggtgatggc 240 ctacgggagc ctggtgtttg tactgctatt tatttttgtg aagaggcaaa tcatgcgctt 300 tgcaatgaaa tctcgaaggg gacctcatgt ccctgtggga cacaatgccc ccaaggactt 360 gaaagaggag attgatattc gactctccag ggttcaggat atcaagtatg agccccagct 420 ccttgcagat gatgatgcta gactactaca actggaaacc cagggaaatc aaagttgcta 480 caactatctg tataggatga aagctctgga tgccattcgt acctctgaga tcccatttca 540 ttctgaaggc cggcatcccc gttccttaat gggcaagaat tttccgcttc taccttgctg 600 gatcttgcga aacactagt 619 <210> 477 <211> 674 <212> DNA <213> Homo (Homo sapiens) <400> 477 gaattcgaac cccttcgggg tgttcgactg ctagagccga gcgaagcgat gcctaaatca 60 aaggaacttg tttcttcaag ctcttctggc agtgattctg acagtgaggt tgacaaaaag 120 ttaaagagga aaaagcaagt tgctccagaa aaacctgtaa agaaacaaaa gacaggtgag 180 acttcgagag ccctgtcatc ttctaaacag agcagcagca gcagagatga taacatgttt 240 cagattggga aaatgaggta cgttagtgtt cgcgatttta aaggcaaagt gctaattgat 300 attagagaat attggatgga tcctgaaggt gaaatgaaac caggaagaaa aggtatttct 360 ttaaatccag aacaatggag ccagctgaag gaacagattt ctgacattga tgatgcagta 420 agaaaactgt aaaattcgag ccatataaat aaaacctgta ctgttctagt tgttttaatc 480 tgtcttttta cattggcttt tgttttctaa atgttctcca agctattgta tgtttggatt 540 gcagaagaat ttgtaagatg aatacttttt tttaatgtgc attattaaaa atattgagtg 600 aagctaattg tcaactttat taaggattac tttgtctgcc cacccctagt gtaaaataaa 660 atcaagtaat acat 674 <210> 478 <211> 663 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (663) <223> n = A, T, C or G <400> 478 tttttttaag ctttcacaat ttttattaaa tcctagtcta nttgaacaat atctgatgtt 60 acagacatca tcccatggtg aacatgttta ataagtgaaa gcaagtcaga catctcatct 120 aagtcattat tttctgcaga ctaagcaata actacacaga acactatggg taaacaaaca 180 cctgctcagt tttcacacaa gccatgttgt ttatcaaatt agatctgcta atattgaata 240 cagtagattc ggtgattgta gttctcatat aagtatctta ttgagataac attttgacag 300 tttcactgac tttccaaata agcataccat aatcaaagaa aagaataaag agtgaagtaa 360 aaactgaaca tgaagagatt aagttattaa aggaaaatga agtaaataaa aagagtgaaa 420 aaccattggg ggtggaagtc aaacaagcct agacatttga ttggaagaga aaagatcaaa 480 tatgaagttc acaaaccaaa agtttataaa ctcaatgcaa tacaaatcct ttttattgta 540 aaagctgagt tgaaactaaa agatctataa aaactgttac ttttggcctt aaacagtacc 600 aactcttatg atcaaaaaag gccacacagt taagattgna ttacttgatt ttattttaca 660 cta 663 <210> 479 <211> 673 <212> DNA <213> Homo (Homo sapiens) <400> 479 gaattcgaac cccttcgaat gaagaactct ccagggatct agtgaataaa ctaaaaccct 60 acatgagctt cctgactcag tgccgtcccc tgtcagcgag catgcacaac gccatcaagt 120 tccttaacaa ggaaatcacc agtgtgggca gttccaagcg ggaagaggag gccaagtcag 180 aacttcgagc agccattgat cggtatgtgc aagagaagat tgtgctagca gctcaggcaa 240 tttcacgctt tgcttaccag aagatcagta atggagatgt gatcctggta tatggatgct 300 catctctggt atcacgaatt cttcaggagg cttggacaga gggccggcggtttcgggtgg 360 tagtggtgga cagccggcca tggctggaag gaaggcacac actacgttct ctagtccatg 420 ctggtgtccc agcctcctac ctgctgattc ctgcagcctc ctatgtgctc ccagaggttt 480 ccaaggtgct attgggagct catgcactct tggccaacgg gtctgtgatg tcacgggtag 540 ggacagcaca gttagccctg gtggctcgag cccataatgt accagtgctg gtttgctgtg 600 aaacatacaa gttctgtgag cgtgtgcaga ctgatgcctt ttgtctctaa tgagctagat 660 gaccctgatg atc 673 <210> 480 <211> 203 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (203) <223> n = A, T, C or G <400> 480 gaattcgaac cccttcgggg ggaggaagag gaggtggagg aggagggtga tgttgatagt 60 gatgaagaag aggangaaga tgangananc tcctcggagg gcttggaggc tgaggactgg 120 gcccagggag tagtggaggc cgntggcagc ttcggggctt atggtgccca ggaggaagcc 180 cantgcccta ctctgcattt cct 203 <210> 481 <211> 482 <212> DNA <213> Homo (Homo sapiens) <400> 481 ccagacgctg cccatggagg cgtccagcga gccgccgctg gatgctaagt ccgatgtcac 60 caaccagctt gtagattttc agtggaaact gggtatggct gtgagctcag acacttgcag 120 atctcttaag tatccttacg ttgcagtgat gctaaaagtg gcagatcatt caggccaagt 180 aaagaccaag tgctttgaaa tgacgattcc acagtttcag aatttctaca gacagttcaa 240 ggaaattgct gcagttattg aaacggtgtg aagacggatt ctttggttga taaattgcta 300 tcattctaaa gtcatggact tcactttcgg caacaaaact aaataaggat ggaacattta 360 ttgaatgaaa aatgcacttt tgtttttcca tttttttaaa taataaaaat cagacaaaca 420 gaaaaaaaaa aaaaaaaggg cggccgctcg agtctagagg gcccgtttaa acccgctgat 480 ca 482 <210> 482 <211> 505 <212> DNA <213> Homo (Homo sapiens) <400> 482 aaaatcttta gctgccaaga aagaagttaa gactctcagt gctgagagag actgaatcca 60 cctaggtgat aaggtgactg gacccagtaa accctttgtg tgctgggggg ttttatgcct 120 tgtagaaccc agtgtgagca agatttgggt accctacata cattcagtag ccaggaaagg 180 gtgattggat tgccagactc tgcctgctgg caaaaggatg agctgtagaa gctgaagtcc 240 taggtagtag atataaagaa gacaaattag gtggcacctt ctagactgtg caatgcatgg 300 atttggaatt gaatttttcc tctaattatt ctagggaaac cctgggctaa gaaaccaatg 360 taaaacctga tgaggtagtc tgtagtcaca ctgggtagag gtagaggcaa ccacaaaatt 420 attcttaaga atgcctccca ggcgcctgga agatgaaact ttctggtgaatatgagctca 480 tggtaaaaat ttaggtcgga tgcag 505 <210> 483 <211> 501 <212> DNA <213> Homo (Homo sapiens) <400> 483 tgcaaaaagg taacaaattc ataactggaa agcaaagaga agaacaagta tgatttggat 60 gataaagcat tgttttaatg gtgaaaactt cacagatcac taatgtttct agaggttaac 120 ttcaagtggg caagctgggg tttttaggta gtcagtggcc tagttcctaa agccacagta 180 taggatctgt taaactgaat gtctgttgaa agtttgtttt agctgcttgg aggcttcctt 240 ttaagacaaa ctgtatgtga ttaagttgtt ttgagggaac tgaagaacct gatgtagccc 300 ctggccagat aactgcctga tttctcagat attatttctc tgggaaacat tctacatagc 360 acaggagctt aagagtggca ttatcttctc gccttaattt ccagagatta tttctgtact 420 gagaatcctg gaactactat gctaggaaat ttaaagctgc atggtctgtc ttgttttcat 480 ttaattattg tgaataccta g 501 <210> 484 <211> 501 <212> DNA <213> Homo (Homo sapiens) <400> 484 gcactaagac caccttctat gaggagcagg gtgactacta cagccagtac atccgggcct 60 gcctggacca cctggccccc gactccaaga gttctgggaa ggggaagaag cagccttctc 120 ttcattacac tgctgctcag ctcctggaaa agggtgtctt ggtggaaatt gaagatcttc 180 ccgcctctca cttcagaaac gtcatctttg acatcacgcc gggagatgag gcaggaaagt 240 ttgaagtaaa tgccaagttc ctgggtgtgg acatggagcg atttcagctt cactatcagg 300 atctcctgca gctccagtat gagggtgtgg ctgtcatgaa actcttcaac aaggccaaag 360 tcaatgtcaa ccttctcatc ttcctcctca acaagaagtt tttgcggaag tgacagaggc 420 aaagggtgct acccaagccc ctcttacctc tctggatgct ttctttaaca ctaactcacc 480 actgtgcttc cctgcagaca c 501 <210> 485 <211> 504 <212> DNA <213> Homo (Homo sapiens) <400> 485 cgcactcttg gaacattctt tctttcaaca acccaaggca tgcttctatc tccttttgag 60 gtttccctct aagtgttacc tctaagatag gcttttcctg gacactctat gatggaacct 120 ctaggatttt ctctattgtt ttatgcttat tttgatattt gattcctaga attttaaata 180 cattatatat catataaaat aaacctttaa atattgaaat gaaaagataa aaatacatac 240 actaagtgaa taggtcaaaa gtgtgagatc atcttgaaca ttatcttgaa gagaagatac 300 caatttacct tctgctcaga tcatggtgta cgatatcaca acctgcctag aataactctc 360 cttttctgaa ccatttattc actacttttg tcttccaatt aaatattagc ctgacttcaa 420 atatcataca ttagtttcct ttgtttatgt aattgaatta tataacatat attcattaga 480 gcctattttt tttaaaattt ttgt 504 <210> 486 <211> 501 <212> DNA <213> Homo (Homo sapiens) <400> 486 gagaggtcac tatggcgcct ttctgcagga cgagtgggac ctgctccaaa gaatgatttt 60 gctggcccac gagaaactct ctgttcctgt cacgtgcaaa atccgtgtct tcccggagat 120 tgacaagacc gtgaggtacg cccagatgct ggagaaggcc ggctgccagt tgctgacggt 180 gcacggacgc accaaggagc agaaggggcc cctgtcgggt gcagcgtcct gggagcatat 240 caaggctgtg cggaaggctg tggccatccc tgtgtttgct aacgggaaca tccagtgcct 300 gcaggacgtg gagcgctgcc tccgggacac gggtgtgcag ggcgtcatga gcgcagaggg 360 caacctgcac aaccccgccc tgttcgaggg ccggagccct gccgtgtggg agctggccga 420 ggagtatctg gacatcgtgc gggagcaccc ctgccccctg tcctacgtcc gggcccacct 480 cttcaagctg tggcaccaca c 501 <210> 487 <211> 501 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (501) <223> n = A, T, C or G <400> 487 accattattt agcagcaaaa aggaaagttt gaagacatta acaggaactg gttaattgta 60 gtccttatct gaaaaggaca gattgaatgc agccaaatta tggcaaagaa atcagtagga 120 caacccctat aaagggtagt tcttttaaaa aaaatttctt tattggcaac aacataaaag 180 atatgaaaga atcactcata atttatcagc ataacatagc tattctcatt tttgcaattg 240 actttttagt tcttgaccaa atgtaatttt tattagttgt gattaactga ttttgtgctt 300 tttttaaaaa aaaaaaaaac ctagaataag acatttgttt tgttaattat tataaatgac 360 tgtattcatt ctgtttatgt accataattt tggatgttcc tacgatgtta aacttttagg 420 ttgtttttaa ttgtttgttc ttatagacaa ctctgtaagg gnttttaact gcttttatca 480 ggagaatgtc aaagaagtcc t 501 <210> 488 <211> 148 <212> DNA <213> Homo (Homo sapiens) <400> 488 attctaagga tgaaatggct acagagcaaa ctgcagctga gagaaaactg cttggagttt 60 ggacagaggt ggaattgagt gtccacaggc cagctgagga ggtggtaccc agcactctat 120 gaacccttcg ctcaagtcag cctggagt 148 <210> 489 <211> 501 <212> DNA <213> Homo (Homo sapiens) <400> 489 gctgtggatt cccctccaag tggaggagga tgggcaggct ggggatcctg gggcaaatct 60 ctgctgtcgt cagcatctgc cacagtaggt catggattga cggcagtcaa ggaaaaagca 120 ggagccactc tacggattca tggtgtaaat tctggatctt ctgaaggagc ccaaccaaat 180 actgaaaacg gagtccctga aataacagat gcagccacag atcagggccc tgcagaaagc 240 ccacccactt ccccttcatc agcctctcgg ggtatgctgt ctgccatcac caatgtggtt 300 caaaacacag gtaaaagtgt cttaactgga ggccttgatg cgttggaatt catcggcaag 360 aaaaccatga atgtccttgc agaaagtgac ccgggcttta agcggaccaa gacgctcatg 420 gagagaactg tttccttgtc tcagatgtta agggaagcta aggagaagga gaagcagaga 480 ctggcacagc agctcacgat g 501 <210> 490 <211> 482 <212> DNA <213> Homo (Homo sapiens) <400> 490 attgcaaact gaaagtggac aaagacttaa ggtaaacctg ctcctcatgg tggaatgctt 60 ccaaatgctg gaaggaggac tttagggcag agttcactaa ggaggcttgt gcttatagat 120 cagtgggcct gaaagaagtt tctctaggtt ctggttgtgt gctgtacgag gtgtaggtag 180 taataatact cttgtcagcc acagtgaagc cccaagctag ccgggatagg ggactgacct 240 tgtacaggca gcatggagaa actaagacag agtgtcctgc ccaagtgatg gcactgggga 300 gcagtcactc aggtttattt ccaccagggc ccaagaaaaa aagaaatgag gcaacctaaa 360 attccatcaa gatagatacc aatatccaag gtgcttggtc ttagcggtgt gggacccacg 420 ttaaggctct tggtgggaag gtgggaggtg ttttcagcat gagatagggt tcaggctgtg 480 aa 482 <210> 491 <211> 483 <212> DNA <213> Homo (Homo sapiens) <400> 491 cgcctctccc cgtgatccct ctctcgctaa ccgtaggcgc ttttcgtgaa ggcccgggtt 60 tttacagcac ttcgcttttc taaccacgaa cagtgctcgt tcgttcgcag ggccagcaag 120 gagagccccg cccccgcccg ccgcccgccg cccgccgccc gccgcctttg gatcccgcgg 180 actccgcccg gcccggcctc cccaggcatg gcgccgctgc gcttctccgc caatctgtcc 240 tggctattcc ccgagctccc cggcctcccc gcgcgggtgc gggccgcggg cagctcgggc 300 ttcgaggccg tcgaggtggc ctggccgtac gcggagacgc ctgaggcgct ggcgcgcgcc 360 gcgcgagaag cggggctgcg gcttgtactg atcaacacgc ccccgggaga ccaagagaag 420 ggggaaatgg ggctgggggc cgtccccggg agacaggcgg ccttccgaga gggactggag 480 cag 483 <210> 492 <211> 266 <212> DNA <213> Homo (Homo sapiens) <400> 492 acctcatctg ctttgctttg gcatgtgagc cttgcctaag ggggcatatc tgggtcccta 60 gaaggcccta gatgtggggc ttctagatta ccccctcctc ctgccatacc cgcacatgac 120 aatggaccaa atgtgccaca cgctcgctct tttttacacc cagtgcctct gactctgtcc 180 ccatgggctg gtctccaaag ctctttccat tgcccaggga gggaaggttc tgagcaataa 240 agtttcttag atcaatcaaa aaaaaa 266 <210> 493 <211> 483 <212> DNA <213> Homo (Homo sapiens) <400> 493 gccgctcgcg ctaggagagc gggcttcggg cacttgacat ggcggcagtg gcggcgactg 60 cagcagcgaa ggggaatggg ggcggcggtg gcagggccgg ggccggggac gccagcggca 120 cgcggaagaa gaagggcccg gggcccctgg ccacggcgta cctggtcatc tacaatgtgg 180 tgatgacagc cgggtggctg gttatagcgg ttggtctggt ccgagcatac ctggctaagg 240 gtagctacca tagcctttat tattcaattg aaaagccttt gaaattcttt caaactggag 300 ccttattgga gattttacat tgtgctatag gaattgttcc atcttctgtt gtcctgactt 360 ctttccaggt gatgtcaaga gtttttctaa tatgggcagt aacacatagc gtcaaagagg 420 tacagagtga agacagtgtc ctcctgtttg ttattgcatg gacgatcacg gaaatcatcc 480 gtt 483 <210> 494 <211> 301 <212> DNA <213> Homo (Homo sapiens) <400> 494 gtggctattt tcatggaata tcttttatca gcctttcagt tttaatttat ttgtgtcttt 60 ggatctaaag tcagtttgtt ttggacaatg tgtagtttga tcatgatttt aaaaaatcta 120 ttctgaagct gggtggttca cacctgtaat cccagcactt tgggaggatc tcttgagccc 180 aggagttgga gactagcctg gtctacaaag tgagactctg tttctacaaa aaaataaaat 240 aaatagttgg gtgtggtggt atgcgcttgt ggttccagct acttgggagg atgagggagg 300 a 301 <210> 495 <211> 496 <212> DNA <213> Homo (Homo sapiens) <400> 495 cgaagtgaag gctaggggcc cgtacgcgcc cgcctgactg tcgccagcag ctcctcggcg 60 gccccaccgc agccgccgct ccctgaggcg cgggaggccc gcgccccgcg gctcgctgtg 120 cgtgggaggg cgcgagcgaa cgcgggcgag gagcggccga gccgctgaag aggagctggg 180 cgccggccgc ccggccgcgc tcggcccgcg gatcgcctcc gcccggtctt cgccggcccc 240 ggcccctggc gagatgccgt gtggggagga ttggctcagc cacccgctgg gaatcgtgca 300 gggattcttc gcccaaaatg gagttaatcc tgactgggag aagaaagtaa ttgagtattt 360 taaggaaaag ctgaaggaaa ataatgctcc taagtgggta ccatcactga acgaagttcc 420 ccttcattat ttgaaaccta atagttttgt gaaatttcgt tgcatgattc aggatatgtt 480 tgaccctgag ttttac 496 <210> 496 <211> 494 <212> DNA <213> Homo (Homo sapiens) <400> 496 aaactatata aaaagtgatt tgtacagaac tttattttag ctctttttta aaaatgattt 60 gcatggttag aaaacggcga ggacagccag gggagggaag ggcctctagg gaactttgca 120 ctttctatac ctttgtacta tgcactgccc tattgattct acacccaata atgatattac 180 ttgaacccat ctgtaagaaa ctgcttcgga aattcatttg tgtgtatgta aataacacaa 240 catagaaaca ggaagggaaa aaagtctgca gtaatgcacg tatttttttt ctttcctgtt 300 tattttcggt tttgctttaa gtccttttat ttttaattcc ctttttgttt ttctttttgg 360 gttttggttc cttttgggtt tatgggtgcc ctgatactcc agcagagatc agaaggctac 420 agatccattc tatccatccg ttatgtggct ttgccatccc agcttggagt gtctttacaa 480 agataataac agtt 494 <210> 497 <211> 184 <212> DNA <213> Homo (Homo sapiens) <400> 497 gcgcgccgcg gctggcaggg tgtgcgtgag tttggtggcg gccggctgtg cagagacgcc 60 atgtaccggc tcctgtcagc agtgactgcc cgggctgccg cccccggggg cttggcctca 120 agctgcggac gacgcggggt ccatcagcgc gccgggctgc cgcctctcgg ccacggctgg 180 gtcg 184 <210> 498 <211> 471 <212> DNA <213> Homo (Homo sapiens) <400> 498 tcttactaca aatggagatg gctattatga aacagcatga gcatgagcct tttatctttt 60 atacttagtg atatactttg cttgaaaatc actcagcaaa gtagttcaca tgatgtgtat 120 catatttgaa gtgtggtttt tctcaaaatc attgacttta aggagctcat ttctgaacaa 180 aaaggtttgc tctgtggaaa aatcaatcac tgccaggatt ctttcatttc tgtactattt 240 tgtataattg aatttgttca cttctctcac accagcaagt gttttacagg tgccttggat 300 taaaacaaaa ttgattttaa aatttttatg taagtcattg tgtctatgat gccactttta 360 aaaggaaaat gcaattgcgt aatggcttat atccttattt aatgtaccta tttgtgttct 420 aataattgtt tgaatgtttt attcagctta aaactttacc atgaagtcat a 471 <210> 499 <211> 478 <212> DNA <213> Homo (Homo sapiens) <400> 499 aggtgggaaa agcggaggag gacgcccagg aggaggcggc ggcggcggcc gggaagtgaa 60 aggtctcgca aagttcagcg gcggctgcgg gcgccgagcc ccgggctagc ggcagacgag 120 cccgcagggc cgctccgcgg ggcagcgcag ccaggccggc tatggtcccg gggctcccgc 180 cgccccccag gtgcccggga cccgccaggc cggtgcgcga gggtcacccc acctccccgc 240 gcggtcccgg cccctggctc ccagctgccg gcgaccgctg accgagcccg gcgccccagg 300 aggaggaaga aaccagggcc ccgttccctc ccgaggacgg cggcgcttca tcccgcagcc 360 cagaggtctc ggctccctcc ggcacccgcc cggcccggct gctcccggct cctcccggcc 420 atggggagct gcgcgcggct gctgctgctc tggggctgca cggtggtggc cgcaagga 478 <210> 500 <211> 495 <212> DNA <213> Homo (Homo sapiens) <400> 500 gggggcttct ggcttggtgt ggaccaggag ggggcagaag gcaccctgtc gtggctgggc 60 accgtcttcg gcgtgctggc tagcctctgt gtctcgctca acgccatcta caccacgaag 120 gtgctcccgg cggtggacgg cagcatctgg cgcctgactt tctacaacaa cgtcaacgcc 180 tgcgtcctct tcctgcccct gctcctgctg ctcggggagc ttcaggccct gcgtgacttt 240 gcccagctgg gcagtgccca cttctggggg atgatgacgc tgggcggcct gtttggcttt 300 gccatcggct acgtgacagg actgcagatc aagttcacca gtccgctgac ccacaatgtg 360 tcgggcacgg ccaaggcctg tgcccagaca gtgctggccg tgctctacta cgaggagacc 420 aagagcttcc tctggtggac gagcaacatg atggtgctgg gcggctcctc cgcctacacc 480 tgggtcaggg gctgg 495 <210> 501 <211> 494 <212> DNA <213> Homo (Homo sapiens) <400> 501 ctgcggtgtg gttggtggtg agatgacgac cttagtgctg gataatggag cttacaacgc 60 caaaatcgtt acagccatga aaatgtgtcg gttattccta attgtcagtt ccggtcaaaa 120 acagcacgtc ttaaaacttt tactgccaac cagatagatg aaataaaaga cccttctgga 180 ctcttttaca tcctcccttt tcaaaagggc tacttggtga attgggatgt tcagagacaa 240 gtttgggatt acctttttgg aaaagaaatg tatcaggttg attttttaga tactaatatt 300 attatcactg aaccatactt taacttcact tcaattcaag aatcaatgaa tgaaattcta 360 tttgaagaat accagtttca agcagtatta agagtaaatg ctggggctct cagtgcacat 420 aggtatttcc gagataatcc ttccgaatta tgctgtatca ttgttgatag tggatattcc 480 tttacacata tagt 494 <210> 502 <211> 479 <212> DNA <213> Homo (Homo sapiens) <400> 502 ttgtataatg ctgaatgtgt ccagagggac aagtttgcag aacctcatat tggtatatta 60 aagaaataat aaaataaaaa agcactttag gttattttat ctttaacccg attgctgcaa 120 tttcttttgt gtgtatatat acatatatat actttccaca aagttttatt ttttgctcag 180 aataaaaagt taaattgagg tgtgaaaaga aaagcactta ccttggtgca atatgtgtag 240 cttgatggtc gttgtcccat gtggccctgg cctggcagcg tttttccgct caatcagccc 300 tgtgctgtga gattgtccat agggaaacac tattatgcat tctcagcaac cgctcaatct 360 atgcaagcct tccctgtgtg ccccagggcg ccccctcagg ctctctgaag aactgctgtg 420 ggtcctgttt tctgctgact gttgaggccc tttttcatca cttcttggtc tctcgccat 479 <210> 503 <211> 451 <212> DNA <213> Homo (Homo sapiens) <400> 503 ttgtgggccg ggtgggtttc ctaatctggt ttcgtctgcc tggttcatct gtgtgcgatg 60 gctccggact cggatccctt ccctgaaggg ccgctcttaa agctgctacc cttagacgct 120 agagaccggg gcacccagcg ctgccgcctg ggcccggccg ccctccacgc cctgggcgcg 180 cgcttgggct cggcagtgaa gatctcgcta cccgacggcg gctcctgcct ctgcactgcc 240 tggcctcggc gggacggagc ggacggcttt gtgcagctgg acccgctgtg cgcgagcccc 300 ggggcggcgg tcggggcgtc gagatcccgg aggagtctca gcctgaatcg cctcctccta 360 gtgccctgtc cgcccctgcg gcgcgtcgcc gtgtggccgg tgttgcgaga gcgggcaggc 420 gcgcccggtg cccggaatac agccgcggtg c 451 <210> 504 <211> 462 <212> DNA <213> Homo (Homo sapiens) <400> 504 cagtggggaa ggggagagat gccgaggtgg tcagtatcct gactttcaga ggcctttttt 60 tgtttgtttt aatttttgct agattgatat taaaaactca tgtggaggaa ctcaaggaat 120 gtttagaaga ccaaaagtcc ccaatgacag gaacaaaagc aaccaatttt taactttctc 180 ttctcattcc tgttttcatt gatttcccac atgtagtcct tttgctcagg aagtctttgg 240 ggaaattaag gatctttgaa gctctgaaat aggtgatcag gttagtggtg tctgtcagct 300 gtctaagagg ttggaaaatg aactactcaa gatagtcacg aaaatactga aagtttgatt 360 tttctttcca tatttgaatt aattttttct gtttgactgg aaggggtttt tgtataacta 420 aaacctcagc gcataaagga gatttaaaag gagcacatga tt 462 <210> 505 <211> 136 <212> DNA <213> Homo (Homo sapiens) <400> 505 tcgattatat cacacatttc agttgggagg ttgtctcaac ctgtgaccac catctgagtt 60 agctggcaga cttctaggag gtcctgtctg aggtagaatc agaaatggct tccctccttc 120 tcccataaaa aaaaaa 136 <210> 506 <211> 466 <212> DNA <213> Homo (Homo sapiens) <400> 506 ggggtacaga gacagcagcc tgcggagcgt tctaggcagg acagggcagc aaacctgaca 60 tgcggagctg ggggcagggg taatggggcc agggggtaat ggcaggtgag gccatggcct 120 agagggttgc catgcttggt gcaggggagg agaggcccag gtgtggctgc agtggcagca 180 ggagtcagtg tggctgtgcc cagtgggatg ttgtcagaga atggacctgg ctgctgggaa 240 aggtgattgt gtttgtctga gccacactgg actcttctct gaccagcaag cacattctgg 300 agatgcgggg cagagacgag gcctccgtga gaacctttga ggtgtgaggg ccttgatctg 360 gggtgcagcc tccagctttc tgcttacaga gcaggacctg caggagctcg ctgactgcct 420 gcacagtgga aggaagacct gtttctttta ctttccttga ggagaa 466 <210> 507 <211> 101 <212> DNA <213> Homo (Homo sapiens) <400> 507 atgatttaat tttttaaact gtagcaattg gatagataat tttatttgaa attttacaca 60 ctgaaagctc taaataaaca gatacattca cattcaaaaa a 101 <210> 508 <211> 242 <212> DNA <213> Homo (Homo sapiens) <400> 508 gacaatgcaa gtaacctcaa atgagagtgt ggaaaggcgg gaaagcagcc agagcttcat 60 tgttatgaaa aaagagtgaa atgtgctctg ttgaagagtt gaagaatgaa caaaggatat 120 ttagtttgaa tggaagctca gtaatgagaa atgagaatgg ttgagttctt aaaagaagca 180 agtaaagaag aggatttgtg ggctactatt ctcattcagt gaatctcatw ccacccttgc 240 ct 242 <210> 509 <211> 101 <212> DNA <213> Homo (Homo sapiens) <400> 509 cctttgctcc ctttttccaa tttcttattg catatctttc tgtattacaa caaaatgata 60 tgcaataaga aattggaaaa agggagcaaa ggcgaagggg y 101 <210> 510 <211> 461 <212> DNA <213> Homo (Homo sapiens) <400> 510 gcaggttcgg gaccatgagt tggattcctt ttaagattgg gcagcccaag aaacagattg 60 tgcccaaaac agtggagaga gactttgaaa gggagtatgg aaaacttcag caccatgtca 120 aaatctgccg tgaagatatc cttggactta ctctccaatc ccctctgtga gcaagaccag 180 gaccttctga acatggtgac ggccctggac acggccatga agcggatgga tgccttcaat 240 caggaaaagg tgaaccagat ccagaagact gtgatcgagc ccttaaaaaa gttcggcagt 300 gtcttcccga gcctcaacat ggctgtgaag aggcgggaac aggccttgca ggactacagg 360 aggctgcagg ccaaggtgga gaagtatgag gaaaaggaga agacggggcc agtgctggcc 420 aagctccacc aggcacgaga ggagctgcgg cctgtgcggg a 461 <210> 511 <211> 461 <212> DNA <213> Homo (Homo sapiens) <400> 511 ggctttctga tatttctaaa attgacctgg aatcaaccat tgacatgtcc tgtgctaaat 60 atgaattcac tgatgccctg ctgtgccatg atgatgagct ggaagggcgc cggattgcct 120 tcatcctgta cctggttcct ccctgggaca ggagcatggg tggtaccctg gacctgtaca 180 gcattgatga acactttcag ccgaagcaga ttgtcaagtc tcttatccct tcgtggaaca 240 aactggtttt ctttgaagta tctcctgtgt cctttcacca ggtgtctgaa gtgctgtctg 300 aagaaaagtc acgtttgtct ataagtggct ggtttcatgg tccatcattg actcggcctc 360 ccaactactt tgaacccccc atacctcgga gccctcacat cccacaagat catgagattt 420 tgtatgattg gatcaaccct acttatctgg acatggatta c 461 <210> 512 <211> 686 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (686) <223> n = A, T, C or G <400> 512 actgacctga aggagaccta agagtccttt ccctttttga gtttgaatca tagccttgat 60 gtggtctctt gttttatgtc cttgttccta atgtaaaagt gcttaactgc ttcttggttg 120 tattgggtag cattgggata agattttaac tgggtattct tgaattgctt ttacaataaa 180 ccaattttat aatctttaaa tttatcaact ttttacattt gtgttatttt cagtcagggc 240 ttcttagatc tacttatggt tgatggagca cattgatttg gagtttcaga tcttccaaag 300 cactatttgt tgtaataact tttctaaatg tagtgccttt aaaggaaaaa tgaacacagg 360 gaagtgactt tgctacaaat aatgttgctg tgttaagtat tcatattaaa tacatgcctt 420 ctatatggaa catggcagaa agactgaaaa ataacagtaa ttaattgtgt aattcagaat 480 tcataccaat cagtgttgaa actcaaacat tgcaaaagtg ggtggcaata ttcagtgctt 540 aacacttttc tagcgttggt acctcgccgc gaccacgctg gaattccgga agggcctgtc 600 ctangatcca gtgtggtgga attctgcaga tatccagcac agtggcggnc gctcgagtct 660 aaanggcccg tttaacccgc tgatca 686 <210> 513 <211> 429 <212> DNA <213> Homo (Homo sapiens) <400> 513 catgaacgac accgtaacta tccgcactag aaagttcatg accaaccgac tacttcagag 60 gaaacaaatg gtcattgatg tccttcaccc cgggaaggcg acagtgccta agacagaaat 120 tcgggaaaaa ctagccaaaa tgtacaagac cacaccggat gtcatctttg tatttggatt 180 cagaactcat tttggtggtg gcaagacaac tggctttggc atgatttatg attccctgga 240 ttatgcaaag aaaaatgaac ccaaacatag acttgcaaga catggcctgt atgagaagaa 300 aaagacctca agaaagcaac gaaaggaacg caagaacaga atgaagaaag tcagggggac 360 tgcaaaggcc aatgttggtg ctggcaaaaa gccgaaggag taaaggtgct gcaatgatgt 420 tagctgtgg 429 <210> 514 <211> 346 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (346) <223> n = A, T, C or G <400> 514 aaaactttct ctacttattt agttttntcc tctgagttca accgctgctg gattcgtttg 60 gcataacttt gtgccatgga gttaatgata gataggatga agtaacacac catgacaacg 120 accaactttt caaacatcca ggacaaccag ttttctccct gtggtgtgcc catttcgctt 180 ttgtggtgaa gcttctgccg ttgagcctcc aggtactcct gaaatggctt ctgcagagat 240 ggacctatgc cggggacagc actggaagca gggtacagta gcccaaagaa aaagacacat 300 ttgggaagaa aagcaggaaa aacgttaaag aaaatgtact taccac 346 <210> 515 <211> 549 <212> DNA <213> Homo (Homo sapiens) <400> 515 ctgaccagga ctgtgaagat gcggttccgc tgcgaagatg gggagacatt ttccaggaac 60 gtcatgatga tccagtcctg caaatgcaac tacaactgcc cgcatgccaa tgaagcagcg 120 tttcccttct acaggctgtt caatgacatt cacaaattta gggactaaat gctacctggg 180 tttccagggc acacctagac aaacaaggga gaagagtgtc agaatcagaa tcatggagaa 240 aatgggcggg ggtggtgtgg gtgatggaac tcattgtaga aaggaagcct tgctcattct 300 tgaggagcat taaggtattt cgaaactgcc aagggtgctg gtgcggatgg acactaatgc 360 agccacgatt ggagaatact ttgcttcata gtattggagc acatgttact gcttcatttt 420 ggagcttgtg gagttgatga ctttctgttt tctgtttgta aattatttgc taagcatatt 480 ttctctaggc ttttttcctt ttggggttct acagtcgtaa aagagataat aagattagtt 540 ggacagttt 549 <210> 516 <211> 382 <212> DNA <213> Homo (Homo sapiens) <400> 516 ccgctcgtca gactccagca gccaagatgg tgaagcagat cgagagcaag actgcttttc 60 aggaagcctt ggacgctgca ggtgataaac ttgtagtagt tgacttctca gccacgtggt 120 gtgggccttg caaaatgatc aagcctttct ttcattccct ctctgaaaag tattccaacg 180 tgatactcct tgaagtagat gtggatgact gtcaggatgt tgcctcagag tgtgaagtca 240 aatgcatgcc aacattccag ttttttaaga agggacaaaa ggtgggtgaa ttttctggag 300 ccaataagga aaagcttgaa gccaccatta atgaattagt ctaatcatgt tttctgaaaa 360 tataaccagc cattggctat tt 382 <210> 517 <211> 323 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (323) <223> n = A, T, C or G <400> 517 acgagcgtag gacgatgctt ctcttntgtc agcctgcaac tgagtcagga ttgaatactt 60 ggaccccagg tctggagatt gggatactgt aatgcttctt tgttattata acataaaagc 120 accactgttc tgttcatttc ctagctgttc taattaagaa aactattaag atgagcaacc 180 acatttagaa atgtttattg acaggtcttt tcaaataatg cttttctaat taatagccaa 240 agatttcata tctaactttg taaccagaat tatacagtaa gttgacacca cttagattta 300 aaggcagaca gttttgcttt agt 323 <210> 518 <211> 605 <212> DNA <213> Homo (Homo sapiens) <400> 518 ctggataccg aggctggggc cccacactgt ggaacaaacc cacagcttgc tcaggatcca 60 tcccagaatc agcagacatc aaatccaacg cacagttcag aagatgtgaa gccaaaaacc 120 ctcccgctgg ataaaagcat taaccatcag atcgagtctc ccagtgaaag gcggaagtct 180 ataagtggaa agaagctgtg ctcttcctgt gggcttcctt tgggtaaagg agctgcaatg 240 atcatcgaga ccctcaatct ctattttcac atccagtgtt tcaggtgtgg aatttgtaaa 300 ggccagcttg gagatgcagt gagtgggacg gatgttagga ttcgaaatgg tctcctgaac 360 tgtaatgatt gctacatgcg atccagaagt gccgggcagc ctacaacatt gtgacacggc 420 tttcaagctt ccggatcact caccatttct ttactgagag tgtcccctgg caactgctta 480 acaaaatccc aagctcaggg gcttctcagc atttacctaa tttctgaaag gctcttctga 540 aaggtggtat ctgttctttc gtagcacagt gtttatgttt ttcctgttta ttggtttggt 600 ttttt 605 <210> 519 <211> 462 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (462) <223> n = A, T, C or G <400> 519 ctgctggtca tgnccttggc agtcttttgt gcaaaataag gcatattnga gctccacatt 60 aaccttgcgg caggcgncta cttgctctgc atgctgtanc agngcacgtc ctccttcccc 120 ttggtggtgt agcctgngan aggctgccca tacttatcca cacaccagca naagccccgc 180 ttcctgcctt tggaagggcg acactgcttt ttcttataaa atcccttctt gtcacagttg 240 ggaatgtgna cacccctggg actcagcaca ttgaggaact tcaagtgatt cagtgtgnct 300 tccatttctc tacggcangn accatattct gtctcccgct tggactcgga ggagaagttc 360 tgggtatctg tgctctgaga ctcgtagtca actttgtagc gctggctgnc tttagcatgc 420 cctttcttga tgatgantat ctttgaatgg agggggtgga ac 462 <210> 520 <211> 565 <212> DNA <213> Homo (Homo sapiens) <400> 520 actcgtaata aatatgcatc cggaaacaag ataaaaggct acacctcgtc aggcatccta 60 caaaaatgtc tcaagtttta tatactctgc agcatttctg tgcgggggca gaaggggctg 120 ttgtgtattt tctgaagtgc tgtgacaaaa ggtcctttca catttctttg gagcattttt 180 gaaattgctt aactataatt aaacaactta agaaaagtaa caccaagctt taaagccatt 240 tttgctttgc tgtcattggt ccttatccaa tacagatcaa catatcatcc agcacagcca 300 agcacccact gaggccaagc agccttgtgg gacatgggcc ctgtcagagc aggccctact 360 ttcagttaaa tactttggag agtccaggat tctgtctctc tccctcaaca agattaatgc 420 cataagggaa gttgcaagcg tgttagaaac atttttaacc tgaaagtaaa gtgaacagaa 480 atattttttt ttccgagacc tctgctatgc accataatat taccatatca gggtttttag 540 cttcaaagtt gaaaaacaga ttggt 565 <210> 521 <211> 127 <212> DNA <213> Homo (Homo sapiens) <400> 521 acatggctga cgtcaccgtc cagtgcaaaa tcaaaaaaga aagaaagaaa aaccccaaag 60 aaagaggatt tttcagtgga gaacatggtg ggctgattag gcttctatta gattacattc 120 atttcac 127 <210> 522 <211> 642 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (642) <223> n = A, T, C or G <400> 522 actatgtttc gtaaattaaa taggtntggc ccagaagacc cactcaattg cctttgagat 60 taaaaaaaaa aaaaaaaaag aaagaaaaat gcaagtttct ttcaaaataa agagacattt 120 ttcctagttt caggaatccc ccaaatcact tcctcattgg cttagtttaa agccaggaga 180 ctgataaaag ggctcagggt ttgttcttta attcattaac taaacattct gcttttatta 240 cagttaaatg gttcaagatg taacaactag ttttaaaggt atttgctcat tggtctggct 300 tagagacagg aagacatatg agcaataaaa aaaagattct tttgcattta ccaatttagc 360 aaaaatttat taaaactgaa taaagtgctg ttcttaagtg cttgaaagac gtaaaccaaa 420 gtgcacttta tctcatttat cttatggngg aaacacagga acaaattctc taagagactg 480 tgtttcttta gttgagaaga aacttcattg agtagctgtg atatgttcga tactaaggaa 540 aaactaaaca gatcaccttt gacatgcgtt gtagagtggg aataagagag ggctttttat 600 tttttcgttc atacgagtat tgatgaagat gatactaaat gc 642 <210> 523 <211> 244 <212> DNA <213> Homo (Homo sapiens) <400> 523 ctgaaggagc tgatccagaa ggagctcacc attggctcga agctgcagga tgctgaaatt 60 gcaaggctga tggaagactt ggaccggaac aaggaccagg aggtgaactt ccaggagtat 120 gtcaccttcc tgggggcctt ggctttgatc tacaatgaag ccctcaaggg ctgaaaataa 180 atagggaaga tggggacacc ctctgggggt cctctctgag tcaaatccag tggtgggtaa 240 ttgt 244 <210> 524 <211> 407 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (407) <223> n = A, T, C or G <400> 524 acgttagtgg tgatgtcacc caccctnnng ctggggccga ggatgctctc attgtgcact 60 gcgtagatga ctctggccac tggggcagag gtggtttatt tacagctctg gaaaagcgat 120 ccgctgagcc aagaaaaata tatgagctgg ctgggaaaat gaaagacctg agtttgggag 180 gtgtcctttt atttcctgtt gatgataaag aatcaagaaa caaagggcaa gatttgttgg 240 ccttgattgt ggctcagcat cgtgatcgtt ccaatgtcct gtctggcatt aagatggcag 300 ccctagaaga gggcctgaag aagatatttt tagcagcaaa aaagaagaaa gcaagtgttc 360 atcttccacg tattggacat gccacgaaag gttttaactg gtatggt 407 <210> 525 <211> 276 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (276) <223> n = A, T, C or G <400> 525 acacaggagg caacgtgttt cacatnatag acttcacttc caactccttg gaatgttcat 60 ttctttggct tacaggagag actagacagg aaggccaggc aatgcttagg caactaaaat 120 gaggttgggg gtaatgctaa cgtcaccctc acagggatgg ccacggggac tgttattcgc 180 aagctggttt tctagacctg ttagctggaa gcatggtgag caccatttct ggacgctcag 240 gccgtgtcgg gcttcagtca tctccaccac acaggt 276 <210> 526 <211> 288 <212> DNA <213> Homo (Homo sapiens) <400> 526 acaattaccc accactggat ttgactcaga gaggaccccc agagggtgtc tccatcttcc 60 ctatttattt tcagcccttg agggcttcat tgtagatcaa agccaaggcc cccaggaagg 120 tgacatactc ctggaagttc acctcctggt ccttgttccg gtccaagtct tccatcagcc 180 ttgcaatttc agcatcctgc agcttcgagc caatggtgag ctccttctgg atcagctcct 240 tcagctcctt cttgctcagg gtgtgcttgt caccctccct gccggagt 288 <210> 527 <211> 412 <212> DNA <213> Homo (Homo sapiens) <400> 527 actttgagct tattgttttt attctgtatt aaatattttc agggttttaa acactaatca 60 caaactgaat gacttgactt caaaagcaac aaccttaaag gccgtcattt cattagtatt 120 cctcattctg catcctggct tgaaaaacag ctctgttgaa tcacagtatc agtattttca 180 cacgtaagca cattcggacc atttccgtgg tttctcatga gctgtgttca cagacctcag 240 cagggcatcg catggaccgc aggagggcag attcggacca ctaggcctga aatgacattt 300 cactaaaagt ctccaaaaca tttctaagac tactaaggcc ttttatgtaa tttctttaaa 360 tgtgtatttc ttaagaattc aaatttgtaa taaaactatt tgtgtaaaaa aa 412 <210> 528 <211> 489 <212> DNA <213> Homo (Homo sapiens) <400> 528 aaatgcaaaa agtcaaagta ggtaacaggt tggtaattaa agtgtcagga agactggaag 60 aggcaaaaat caagcagagt tccaataagt gtatgaaaaa aaaaatcata actgaaggtt 120 taagaaaagt ccccaaaggc agaatcacaa tatgagcagg aggaataaaa agcttttgga 180 tataccaggc agctttctgt acgactcagg tttacaggtg aaattcctca gtttgagttc 240 agaagaattt gaacttattc cagcaaaata cttcaatctt tttattactg cctcctcccc 300 catcttcttt ctgggcaaag ggatgcttgg attaggtcca aagctcctgg cagggggagg 360 ggccatgtgt cacagcataa cagacggttg caagtgcttt actgagcagg ggtcaggttt 420 gcagcaactc tgataggctc acacaatggc ctccatttta cagcccctcc ttggaggccc 480 actgatcag 489 <210> 529 <211> 631 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (631) <223> n = A, T, C or G <400> 529 acttgcctaa agtttttata tctgnntctt ctgctgtaaa tcttcccttc ataaatgaaa 60 attttaataa aatcaactat gtggaaatat ataattaaag gaattcacta actgtgattt 120 tcataattta gggacattct cttctagtaa gcatggtgca ttatttacta gagatataat 180 atgcattaaa acaaaaaatg ttttctatca tcatagaaaa gtttgaggtc cagggataat 240 catctctgga tacattattt cctaccgtcg tggtacacac tgaacacatt tgaggcttat 300 gactggttct tttacttaca aatattgttt agacacattt tcaaatgtca caccaatcaa 360 taataataag gaatggattt tatctatatt gacagttctt tcaaccttaa gagtgaactg 420 ctacaggtaa gattcaatca catttttcag gagaaagcta ttgagaccaa tatgctttgg 480 ttatctaata ggggtggaat gacttataat gctatttact ccaggcaaag agaaaataca 540 acagacatag gatcttgatt tcaacgtagt tctcctccat gtgcatttct ctgtccgttt 600 aggcaatgcc aactggtcca ccagtgaaca t 631 <210> 530 <211> 316 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (316) <223> n = A, T, C or G <400> 530 acacatttaa atgactcacg agantnaagt ttttttcaaa tatattaaga tcacaccacc 60 ttgttgttta tcgaaagata ttcaaggaga aagatctgac tctccaaact gcatctgaga 120 ttgccacttt aaacagacct catttcaaac atgcaacaac gccactggta ataaagcttt 180 ggaatgggtg ctcattctat tatttcacta caaacagcat agaaagcaag agaagttggg 240 aatttattct aaaatagaat ggaggttgtc atctacagca gcactcctca ctcctctgtt 300 gccattttta gcaagt 316 <210> 531 <211> 296 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (296) <223> n = A, T, C or G <400> 531 aaagtatcat ttatttgaaa aacatacatt atcattntgt ttttgatatt tgataatgaa 60 aaaaatcttt gnttgtttat ttctgaaaaa gaactgtatt tagngattat tttagatagt 120 gatattatan cattcatctg tgtgtaaatt atttcatata gggaagagtt ctgatctgta 180 cctatggttc ttattgaaaa caacattgga tgtgcatttc tgtgatgtta tgaatacatt 240 tctactttat tttgaaacat ttgccaaact aaatactgta acactgtata acattt 296 <210> 532 <211> 266 <212> DNA <213> Homo (Homo sapiens) <400> 532 acatatgcac caaattccat tttagaagtt tccatatcat tttcatagaa aacaaagttt 60 gaaaacaagt aacatttaaa cacagcacgg tattctacca caactgaaac ttttttcttc 120 ttcttcttta caggactcaa caaaatctaa aaatgaacta tgctgtagat ttacctcatg 180 caaagatctt tatgttatct ctgaaaatga aaaggatggc cttttaagca cattttactg 240 ttttatacta ttatggcaac ttgtgt 266 <210> 533 <211> 289 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (289) <223> n = A, T, C or G <400> 533 actcagaagt cacttttaat atcancgaca gaaatatttc actaattcaa ctgaggcaaa 60 tttcctttct agacaaagga cctagaaatt gagcatgcaa aacatccatc cattcattca 120 ttcaaataat tagccaattt taccgtcatt taattccacc agaagcaaat actagaatat 180 ctagaagtag tttgggtaaa gaaacattta cattttaata ttgtgtaatg tcataaattt 240 ggggctaaaa taacaccagg tcaaatttga tccctttgta tgtgagggt 289 <210> 534 <211> 293 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (293) <223> n = A, T, C or G <400> 534 aaaataaaag gttctttaca agatgatacc ttaattacac tcccgcaaca cagccattat 60 tttattgtct anctccagtt atctgtattt tatgtaatgt aattgacagg atggctgctg 120 cagaatgctg gttgacacag ggattattat actgctattt ttccctgaat ttttttcctt 180 tgaattccaa ctgtggacct tttatatgtg ccttcacttt agctgtttgc cttaatctct 240 acagccttgc tctccggggn ggttaataaa atgcaacact tggcattttt atg 293 <210> 535 <211> 408 <212> DNA <213> Homo (Homo sapiens) <400> 535 acttgaacac ttaaagagaa aaactctaaa taaagtcata gaggggatgg tagagatgac 60 cacagaaaat gaccacggag agtattatga agattgcaag attagacatt gatgatgtaa 120 attactccct ttctagataa aataatccat agatgtttat gaatcatatt tgtatgatta 180 ttgctgttac tattattttg acacattatt tattattatt gttgtcacta ttattaccat 240 taagatagca ggcgtaaaac tgtactggtt ccttcagtag tgagtatttc tcatagtgca 300 gctttattta tctccaggat gtttttgtgg ctgtatttga ttgatatgtg cttcttctga 360 ttcttgctaa tttccaacca tattgaataa atgtgatcaa gacaaaaa 408 <210> 536 <211> 184 <212> DNA <213> Homo (Homo sapiens) <400> 536 acctctcatc aaggctctgc ctacaggcac attgtgatgt atctctgcac tgatcaccta 60 ggtcatgtaa cttttttcta ggctctacct acgatggcat tgtgacataa ctctgcacta 120 atcatccacg tgatgtaact cttgtctagg atgtgcctaa attaactttt tgacgtaacc 180 ctgt 184 <210> 537 <211> 311 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (311) <223> n = A, T, C or G <400> 537 ccacagttgt atcatatagc atctntaaca tttcatctag gattatctag tatagatctt 60 actatatttg gggctatgtt gtatacaatg ttaacaagaa catatcttct ctgcatatat 120 gtgtgaatta taaagaaaag catgagaatg actctaagtt caacaaacat gggtgaatct 180 ctatgtgctc ccagtgtcct ggatgggctc cccagcaagc cattcctcct tcctgttctg 240 atattactat tcttttttac attgtgctaa ggaggacaaa aggtgagaga tgaaaataaa 300 gccttgcctt t 311 <210> 538 <211> 302 <212> DNA <213> Homo (Homo sapiens) <400> 538 aaaataaaaa agcaaaaact cttgtggtac ctagtcagat ggtagacgag ctgtctgctg 60 ccgcaggagc acctctatac aggacttaga agtagtatgt tattcctggt taagcaggca 120 ttgctttgcc ctggagcagc tattttaagc catctcagat tctgtctaaa ggggtttttt 180 gggaagacgt tttctttatc gccctgagaa gatctacccc agggagaatc tgagacatct 240 tgcctacttt tctttattag ctttctcctc attcatttct tttatacctt tcctttttgg 300 gg 302 <210> 539 <211> 396 <212> DNA <213> Homo (Homo sapiens) <400> 539 actgtttatt tgctccttct cttcatgcct gtggctggat gtcccacaac actataagaa 60 atataagtca agccctttgt gttaagcaag aactacagac tccatctttt cacccaaatc 120 atgaatgacc aataaaaagc aagttattcc agaggaagaa gcagcccttg aaatgttaag 180 gcttaggctt gaaaggtgaa gagcaggaat tctctctttc aaatcctaga gcataaaccc 240 atgtgtggcc aagtgagatc agccctcaag ggcacatgcc aagggcagag cagcccatgt 300 agacagcttc ggagggcatg ggggtgtagg gagttcgggg tagctcctca ttaactattt 360 gttgggtgag taaaggggtg aggctcagtg gcaggt 396 <210> 540 <211> 634 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (634) <223> n = A, T, C or G <400> 540 ccaaaaacaa gatgaccaga tttgntttna gcctgatgac cctacaggtc gtgctatgat 60 atggagtcct catgggtaaa gcaggaagag agtgggaaag agaaccaccc cactctgtct 120 tcatatttgc atttcatgtt taacctccgg ctggaaatag aaagcattcc cttagagatg 180 aggataaaag aaagtttcag attcaacagg gggaagaaaa tggagattta atcctaaaac 240 tgtgacttgg ggaggtcagt catttacagt tagtcctgtg tctttcgact tctgtgatta 300 ttaaccccac tcactaccct gtttcagatg catttggaat accaaagatt aaatccttga 360 cataagatct catttgcaga aagcagatta aagaccatca gaaggaaatt atttaggttg 420 taatgcacag gcaactgtga gaaactgttg tgccaaaaat agaattcctt ctagtttttc 480 ttgttctcat ttgaaaggag aaaattccac tttgtttagc atttcaagct tttatgtatc 540 catcccatct aaaaactctt caaactccac ttgttcagtc tgaaatgcag ctccctgtcc 600 aagtgccttg gagaactcac agcagcacgc ctta 634 <210> 541 <211> 221 <212> DNA <213> Homo (Homo sapiens) <400> 541 cacacaagca gcagagacca tgggaaccct ctcagcccct ccctgcacac agcgcatcaa 60 atggaagggg ctcctgctca cagcatcact tttaaacttc tggaacctgc ccaccactgc 120 ccaagtcacg attgaagccg agccaaccaa agtttccgag gggaaggatg ttcttctact 180 tgtccacaat ttgccccaga atcttaccgg ctacatctgg t 221 <210> 542 <211> 287 <212> DNA <213> Homo (Homo sapiens) <400> 542 cctcttctac tatggcagga gatgtggcgt gctgttgcaa agttttcacg tcatcgtttc 60 ctggctagtt catttcatta agtggctaca tcctaacata tgcatttggt caaggttgca 120 gaagaggact gaagattgac tgccaagcta gtttgggtga agttcactcc agcaagtctc 180 aggccacaat ggggtggttt ggtttggttt ccttttaact ttccttttgt tatttgcttt 240 tctcctccac ctgtgtggta tattttttaa gcagaatttt atttttt 287 <210> 543 <211> 274 <212> DNA <213> Homo (Homo sapiens) <400> 543 acttgtgaaa cacagctgtt cttctgttct gcagacacgc cttcccctca gccacaccca 60 ggcacttaag cacaagcaga gtgcacagct gtccactggg ccattgtggt gtgagcttca 120 gatggtgaag cattctcccc agtgtatgtc ttgtatccga tatctaacgc tttaaatggc 180 tactttggtt tctgtctgta agttaagacc ttggatgtgg tttaattgtt tgtcctcaaa 240 aggaataaaa cttttctgct gataagataa aaaa 274 <210> 544 <211> 307 <212> DNA <213> Homo (Homo sapiens) <400> 544 ccaggtggtt gtcttattgc accatactcc ttgcttcctg atgctgggca atgaggcaga 60 tagcactggg tgtgagaatg atcaaggatc tggaccccaa agaatagact ggatggaaag 120 acaaactgca caggcagatg tttgcctcat aatagtcgta agtggagtcc tggaatttgg 180 acaagtgctg ttgggatata gtcaacttat tctttgagta atgtgactaa aggaaaaaac 240 tttgactttg cccaggcatg aaattcttcc taatgtcaga acagagtgca acccagtcac 300 actgtgg 307 <210> 545 <211> 570 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (570) <223> n = A, T, C or G <400> 545 accttagaaa tttgcaacca cctccctgaa agtcttctcc cacgttatta agtgcaatgt 60 ttatggtaaa tgtagaagca tcatgatgag gacgaagaga acgctgtcgt tcaggggagt 120 attttactac aaaattcagt agtgcaaatc ccttcgtata atagcctgca aagaccttca 180 gtgtaactgg ngcaatgaac tcccggataa aatgaagcca tacattctcc agatcaactt 240 gcttcatgtg gatatcatca gttgggacat tttcataacc accagatata cggctatcat 300 gatgttttcc cccagaccat ttgccgtaat gttccatttc ttctaccaat tcatcacagg 360 ctttttcaga aaatatgggg aaccaaaaga catctggaca gggctgttca actatatttt 420 cagtgaaaat ctttgaataa tcacggttta tatacttttc cttccagtcc acaggatttt 480 caaaaatctg ccagaggtca ttgttataat gggaagtatt gtaattagca gtggataata 540 gccttccaaa ttcatgtcta ttagaaatgt 570 <210> 546 <211> 589 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (589) <223> n = A, T, C or G <400> 546 aaaaatactt tttaccaaag gtgctatttc tctgtaaaac actttttttt ggcaagttga 60 ctttattctt caattattat cattatatta ttgtttttta atattttatt ttcttgacta 120 ggtattaagc ttttgtaatt atttttcagt agtcccacca cttcataggt ggaaggagtt 180 tggggttctt cctggtgcag gggctgaaat aacccagatg cccccaccct gccacatact 240 agatgcagcc catagttggc ccccctagct tccagcagtc cactatctgc cagaggagca 300 agggtgcctt agaccgaagc caggggaaga agcatcttca taaaaaactt tcaagatcca 360 aacattaatt tgtttttatt tattctgaga agttgaggca aatcagtatt cccaaggatg 420 gcgacaaggg cagccaagca gggcttagga tatcccagcc taccaatatg ctcattcgac 480 taactaggag ggtgagttgg ccctgtctct tcttttttct ggacctcagt ttccttcagt 540 ggagcttggt aaaaatgcac taccntttga tttgataagg tataaatct 589 <210> 547 <211> 293 <212> DNA <213> Homo (Homo sapiens) <400> 547 actcctatta ttgactgtag tcaatcaaac ataaaaaggt gaaagtaaaa tttaattttt 60 tacccttatt ttactgacca atatggaagt tcttggtatc tttaaggctg accttcctgg 120 tattgtgtaa tgattgaatg tatctaaact gtaataattt gaaactgaca aacataacct 180 tctcagactt acaaaactat gttctttcta aagatacaga tttttattat tttattttga 240 ctaggaagga tttataaata aatgtaatga aaaatctttg atcttaataa agt 293 <210> 548 <211> 98 <212> DNA <213> Homo (Homo sapiens) <400> 548 aaacaaaggt tgagatgtaa aaggtattaa attgatgttg ctggactgtc atagaaatta 60 cacccaaaga ggtatttatc tttacttttt tttgtaca 98 <210> 549 <211> 121 <212> DNA <213> Homo (Homo sapiens) <400> 549 acatgcatat ttcaaagacc tgttaatggc gtccactttg gattcttaca tgaaacgatt 60 cagtgcacat tgtaagccta aggaccacgc aaaagggttt cccacatatt aagtattcag 120 t 121 <210> 550 <211> 509 <212> DNA <213> Homo (Homo sapiens) <400> 550 acaatagtat acattttata atgatgaact tataatgatt aagggacatt tctataaaaa 60 tactacaata gttttatgca caacttccca ttaaaaatga gatttcttat ttgtttgtct 120 gtttttactc tgggagtaat actttttaaa ttacctttac atatatagtc actggcatac 180 tgagaatata caatgatcct ggaaattgca gtaacaaaag cacacaacga ttatagtaac 240 tataagatac aataaaacaa ataaatgtga aagtagattc atgaaaatgt attcctttaa 300 aatattgttt tcctacaggc ctatttaaca agatgtttca ttttactgta tattttgtag 360 ttaatataaa tgttgctcta atcagattgc ttaaaagcat ttttattata tttatgttgt 420 tgaactaata tatgaaataa gtaaatgtag ctcccacaag gtaaacttca ttggtaagat 480 tgcactgttc tgattatgta agcatttgt 509 <210> 551 <211> 427 <212> DNA <213> Homo (Homo sapiens) <400> 551 accatggtta tatgattaat cttgggacaa agaattttat agaaattttt aaacatctgg 60 aaaagaagct taagttttat catccttttt tttctcgtga attcttaaag gattatgctt 120 taatgctgtt atctatctta ttgttcttga aaatacctgc attttttggt atcatgttca 180 accaacatca ttatgaaatt aattagattc ccatggccat aaaatggctt taaagaatat 240 atatatattt ttaaagtagc ttgagaagca aattggcagg taatatttca tacctaaatt 300 aagactctga cttggattgt gaattataat gatatgcccc ttttcttata aaaacaaaaa 360 aaaaaataat gaaacacagt gaatttgtag agtgggggta tttgacatat tttacagggt 420 ggagtgc 427 <210> 552 <211> 340 <212> DNA <213> Homo (Homo sapiens) <400> 552 cctcaaggcg gtccaattat ccacttgcag attctacaga aagagtgttt caaaactgct 60 ctgtcaagag aaatggtcca ccgtgtgtgt ggaatgcagc catcacacat tagtttctga 120 gattgcttct gtcttggttt tatggggaga tatttccatt tctagcatag gcttcaaggc 180 gctctaaata tccgcttgga aatactacaa aaacagtgtt tcaaaactgc tgtatccaaa 240 ggaaggtgcc actcgctgag ttgaatgcac acatcacaag gaagtttctg agaattcttc 300 tgtctagatt catacgaaga aatcccgttt ccaacgaagg 340 <210> 553 <211> 549 <212> DNA <213> Homo (Homo sapiens) <400> 553 acttgagctg tgaggtcatc ggaatcccga cacctgtcct catctggaac aaggtaaaaa 60 ggggtcacta tggagttcaa aggacagaac tcctgcctgg tgaccgggac aacctggcca 120 ttcagacccg gggtggccca gaaaagcatg aagtaactgg ctgggtgctg gtatctcctc 180 taagtaagga agatgctgga gaatatgagt gccatgcatc caattcccaa ggacaggctt 240 cagcatcagc aaaaattaca gtggttgatg ccttacatga aataccagtg aaaaaaggtg 300 aaggtgccga gctataaacc tccagaatat tattagtctg catggttaaa agtagtcatg 360 gataactaca ttacctgttc ttgcctaata agtttctttt aatccaatcc actaacactt 420 tagttatatt cactggtttt acacagagaa atacaaaata aagatcacac atcaagacta 480 tctacaaaaa tttattatat atttacagaa gaaaagcatg catatcatta aacaaataaa 540 atacttttt 549 <210> 554 <211> 321 <212> DNA <213> Homo (Homo sapiens) <400> 554 acctaataat atgttaacat aaacataaca acacacatat tatttttcta ccccttggca 60 actgaaaatg aagttaccat tcctaggcca aatttttaga caaagctttc taaaaccatc 120 tttataaagt aaattcagat atgcttacaa taaaaagaca taaaagattc atcctgagat 180 gaattctgag tcaataacta aaaaccattt ctaccagtgc atcactacca tgtaatccat 240 tctacgcaag ctctacaaat attgagtcaa atcctgtctg tcagaaaatg aagacccaat 300 aagtttgccg aagtattcag t 321 <210> 555 <211> 322 <212> DNA <213> Homo (Homo sapiens) <400> 555 ctggatcccg agaatactgg aacaatagag ctcgacctta tctcttggct ctgtttctca 60 gtactttgaa gttataacta atctgcctga agacttctca tgatggaaaa tcagccaagg 120 actaagcttc catagaaata cactttgtat ctggacctca aaattatggg aacatttact 180 taaacggatg atcatagctg aaaataatga tactgtcaat ttgagatagc agaagtttca 240 cacatcaaag taaaagattt gcatatcatt atactaaatg caaatgagtc gcttaaccct 300 tgacaaggtc aaagaaaact tt 322 <210> 556 <211> 286 <212> DNA <213> Homo (Homo sapiens) <400> 556 aaaaaatatg tatctaagaa tgttctaggg cactctggga acctataaag gcaggtattt 60 cgggccctcc tcttcaggaa tcttcctgaa gacatggccc agtcgaaggc ccaggatggc 120 ttttgctgcg gccccgtggg gtaggaggga cagagagaca gggagagtca gcctccacat 180 tcagaggcat cacaagtaat ggcacaattc ttcggatgac tgcagaaaat agtgttttgt 240 agttcaacaa ctcaagacga agcttatttc tgaggataag ctcttt 286 <210> 557 <211> 459 <212> DNA <213> Homo (Homo sapiens) <400> 557 acagaagatg aataataatg aaaaactgtg attttttgac tatcacatac attgtgttaa 60 aaaacaggta aatataatga ctattactgt taagaaagac aaggaggaaa actgtttcaa 120 tgttcaggtt taaatactaa gcacaaaaat ataacaaatt ctgtgtctac aataattttt 180 gaagtgtata caagtgcatt gcaaatgagc tctttaaaat ttaaagtcca tttccccttt 240 agccaagcat atgtctacat ttatgatttc tttctcttat tttaaagtct cttctggttt 300 agttttttaa aaagtttcat catggctgtc atcttggaat ctagcctcca gctcaaagct 360 gagacttcac gcatacatat tctcctttct gggtgcatct tcacctagtt tctccaagta 420 ttcagagtta aatagcacaa cttcttttat atgttccct 459 <210> 558 <211> 303 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (303) <223> n = A, T, C or G <400> 558 aaaaaataaa aaacaagaca acaatttagt agaagtaccn ctgggaggga ggggagggga 60 aaaaaggata tacaggggca ggngtattct ctgtacagag gtgcananaa aatttcacat 120 anctttanag aatgccttgt ggaaaaaaaa aaataggccc caatacttgt tactgccctt 180 tatcaaaact gtgtgcatga cctgcacaaa taaaatcaca aaacagtgtt gccacattct 240 tcaaggaaac aaagcaaaat ttagggggnt tcttttccct ctccttgtta aaagtcattt 300 ttt 303 <210> 559 <211> 232 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (232) <223> n = A, T, C or G <400> 559 aaagcattta ttaagaattt actcaggcat gatggcccat acttgtaatc ccagctattg 60 ggaaggatga gatgggagga tggcttgagg ccagaggttt gagaccgacc agccagggca 120 acacagtgag accccttctc aaaaaaaaaa aaaaaaaaag agagagtgtg tgattagaag 180 ctaaatagga aagttttgag cttcaagtca gngaggagta aaaaagattt tt 232 <210> 560 <211> 336 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (336) <223> n = A, T, C or G <400> 560 ctctgcaaaa ataannataa aaaaataaat aaaattttaa aaataataaa attcactata 60 tacacatata aagaaataaa aagaagtctc agttgcagct atttgtcaaa attaatatcc 120 atttcttttt atatacggtg aatattgcgc aattatagat ctggattttg aaccacttaa 180 tgaagcggca acaccaggtg ttttgaggtg ttggcattct tcgctgattt ggctgttccc 240 aatgtttaca ttatttaatc ttgcaaaaat ggttctgtgc acttggatgn gaaatgctgn 300 ccagntttat tttttttatg ttgntatcct tggatg 336 <210> 561 <211> 636 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (636) <223> n = A, T, C or G <400> 561 acattatggg ttttattgct ttcttttatg gtagacctgt taatggggaa aaaatacatc 60 aaatcaaata gaatcttata tctgtatgtt aaaatagagc acttacctga agtcagtggc 120 ctggatcata gccctggatc atttcccagt ctgtcctgtg ctgtgtgacc ttggacaagg 180 cgcttcatct ctctgggcct ctatttctcc atttgtaaaa caagtggctg cagtagatga 240 tggctgagag cccttcctgt tcccagatgc cttggtccaa agaccccacc cctctgctgg 300 tcctgccaac gtgttggtgc tataagctgc ttcagatata aaattggttt atctataatg 360 tttgttcatt taatagcttc taaaaggcct ttttgttata cagtgctttt tttctagttt 420 tatggacttg gttactgtaa taatgtcttg tttttagcca tgtaactaca aacagatatt 480 ctcttgatgt cttagtaaat ttgcatttga tatatcattg atgagatttt gttgttatgt 540 aatattcttt ggctacgcat ctgtccagca tcttattaac cataatactg ngatcattat 600 ttggaaatat gtcctatgga aagaataaaa gcatgt 636 <210> 562 <211> 708 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (708) <223> n = A, T, C or G <400> 562 acagtccacc ttttgataca tgccatgcct ttgatcaaag aacaggacat aaaaacaaag 60 tcacaatgac attccatagt aaatttggaa tcagaactcc aaatgcaact tcgggctcgc 120 tggagaacaa ctaaggggca ccaaaccctc tgaggtttta ctttaaggtt cgctgtatgt 180 ttgccttgga caaaaaggct acctaccacg tgctatccag taatatactt aaataagcca 240 atacttagat ctactgtaag gcagatgcta attataaggc attaagtaag caaatagtgc 300 cctcagctac tgcagaagaa aagtcccact gaggaaaaga aagtcttgtg atttttaaag 360 gcaagttttc aagtgctctc atagttctat cctctaattc cattaaatcc atactaggag 420 cgtcagtgag ggttttcata gcttttggaa atactttggt ctctgaactg taattagcaa 480 gaagtaaaaa cagaaacgtc aaacgtcaaa tgtttgcttt gttacctgga ggactaaatg 540 tagatgtctt tagtatactt tgtatgttct taatattgga agataatttt gtgaatctgt 600 agattttatt ttttcagtct taccttacaa atttcttttc tatgaataat agaggactta 660 cngcactctg ccatttgtta atgaaaggaa ggcngangat ttagaaag 708 <210> 563 <211> 290 <212> DNA <213> Homo (Homo sapiens) <400> 563 ccagatgctc atccactttc agactttcat ctcttctgcc atctgccaaa gtcaacagag 60 ctttccggaa gtcaccagat gtttcggaac taatgtcatc tccaagactc ttcttgtata 120 ctgtataata ggcttgagag atatccttca tttgcctgct tgtcctggta gttaagattt 180 caatcaaggc atcttcgttt gttcccgcgc ccttcatgga tttctttagc tgctttgcat 240 caaagactgc tggtggagtc actagggcca ccatgagatg ctcaaagtgg 290 <210> 564 <211> 530 <212> DNA <213> Homo (Homo sapiens) <400> 564 accaccagat acttaaagct tcaaaaagac tgcccctacc accacaggag gaccagccta 60 accatacgct ccaaaagatg gctgtgatag atcttgtgaa gcaattactg agcagatcaa 120 gatctttggg aaggaacact aaagatgttt tgaatgaatt atagtccact ggcattttag 180 tgtatttttt tttcttttta gaaacacaca tttctaaaaa tgtcatgtta cattcctgca 240 tgtccctttt gatagcatta gtggatccat tggatttctt ttttcttttt gtgagacagc 300 ttttagtctt acctgaattt atgtgtgttt ttccgacagt ggttaataat tatattggtg 360 atgtagcagc aattgtgttg gcagggtttt catatattat tagtaattaa cactaactgt 420 tggactgact tgtgtcgata gcgctcacgc aagcatggtt aacgtcccta aaacccgccg 480 gactttctgt aagaagtgtg gcaagcacca accccataaa gtgacacagt 530 <210> 565 <211> 450 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (450) <223> n = A, T, C or G <400> 565 ctgcttacgg aagcgctgnn tgactaggat gtgatttatt aacgaccaac ttctgttatt 60 gtgtgttaag tttttcatct gtgcatcaaa tcacaaaaag aataaataga gctttttcct 120 ttatcagtcc cttgggcaca gcaggtcctg aacaccctgc tctacaatgt tgcatcaaga 180 gttcaaacaa caaaataaaa aatattaaga ggaaatcccc atcctgtgac ttgagtccct 240 taagtctaca ggggctggtg acctcttttt gctaatagga aaatcacatt actacaaaat 300 ggggagaaaa ctgtttgcct gtggtagaca cctgcacgca taggattgaa gacagtacag 360 gctgctgtac agagaagcgc ctctcacatc tgaactgcat actgagcggg caagtcggtt 420 gtaagttcag taaaaccctc tgatgatgcc 450 <210> 566 <211> 563 <212> DNA <213> Homo (Homo sapiens) <400> 566 acttgagctg tgaggtcatc ggaatcccga cacctgtcct catctggaac aaggtaaaaa 60 ggggtcacta tggagttcaa aggacagaac tcctgcctgg tgaccgggac aacctggcca 120 ttcagacccg gggtggccca gaaaagcatg aagtaactgg ctgggtgctg gtatctcctc 180 taagtaagga agatgctgga gaatatgagt gccatgcatc caattcccaa ggacaggctt 240 cagcatcagc aaaaattaca gtggttgatg ccttacatga aataccagtg aaaaaaggtg 300 aaggtgccga gctataaacc tccagaatat tattagtctg catggttaaa agtagtcatg 360 gataactaca ttacctgttc ttgcctaata agtttctttt aatccaatcc actaacactt 420 tagttatatt cactggtttt acacagagaa atacaaaata aagatcacac atcaagacta 480 tctacaaaaa tttattatat atttacagaa gaaaagcatg catatcatta aacaaataaa 540 atacttttta tcacaaaaaa aaa 563 <210> 567 <211> 424 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (424) <223> n = A, T, C or G <400> 567 ccagtgagca aattgaaaac caactgaaag caaatccaaa tgaggaagat tttaataaag 60 gaataccctt ctccatagca ggtgcaatgc tgactgctca aggcgtgcgt gcgcgcgcac 120 acacacacac acacacacac atacatactc tcacacacnc atctttccaa ttaaactgca 180 ggtagaatga gattttgtgt tattcaaaaa atttgtaagt gatcaaaanc actgctatgg 240 aatgcctgtt tatctgcctt tgntctggtt aaaatctcat aaaaatacat tcaacaggaa 300 aacatanatt gtatgtgtat aaatatatat gtatatatat atattatata cacatgcaca 360 caaatacttt tgttttttga agcataagat agttacataa atactcctat aattgctaaa 420 gttt 424 <210> 568 <211> 392 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (392) <223> n = A, T, C or G <400> 568 actggctcac tcagagagga cgtccttcaa ctatgccatg aaggaggctg ctgcagcggc 60 tttgaagaag aaaggatggg aggtggtgga gtcggacctc tatgccatga acttcaatcc 120 catcatttcc agaaaggaca tcacaggtaa actgaaggac cctgcgaact ttcagtatcc 180 tgccgagtct gttctggctt ataaagaagg ccatctgagc ccagatattg tgggttganc 240 aaaagaaagc ttggaagccn caagaacctt gtgatattcc agttccccct gcantgggtt 300 tgggaagtcc ctgccntttt gaaagctggt ttgaagcgaa tgttcatagg aaagtttgct 360 taccacttac cctgcccatg gtangacaaa ag 392 <210> 569 <211> 559 <212> DNA <213> Homo (Homo sapiens) <400> 569 aaagagattt attaaatcat cttatcacaa agatggaaac atatacaaac tagaaacatg 60 caaccatcat cttccacagt caagtcacaa tgtcaaatat ttttcttgcc tctgcagatg 120 aaaagttcag atcttatacc caactactta ctcaccccga atatttaagt cagtcttcct 180 gaaagtactc agggtagcaa gtaacaaaat gcaaacgatt atataaagaa agtgcagtta 240 aaaaggaaac tatgtggcaa gtaccctctt tcccttccca ccccccaatt aaaggcaaac 300 aatggcactt tgctcttgct taacctagat tgtcttcaaa aactattaaa atgtaaaaga 360 cttaacaaaa aaacaaaaag acgtttaaca gatgtcaaaa agctccttag tgtttgaaaa 420 taaatgctta aacaaaagac aacatatttt atatcaaaca agtttgaaga gccctgaatt 480 gcagcattct gtaacataaa caaacaaaaa gctggtatag gatttattgg caaaggcaga 540 atttcttcaa gcagggtaa 559 <210> 570 <211> 368 <212> DNA <213> Homo (Homo sapiens) <400> 570 agccgccgct ggatgctaag tccgatgtca ccaaccagct tgtagatttt cagtggaaac 60 tgggtatggc tgtgagctca gacacttgca gatctcttaa gtatccttac gttgcagtga 120 tgctaaaagt ggcagatcat tcaggccaag taaagaccaa gtgctttgaa atgacgattc 180 cacagtttca gaatttctac agacagttca aggaaattgc tgcagttatt gaaacggtgt 240 gaagacggat tctttggttg ataaattgct atcattctaa agtcatggac ttcactttcg 300 gcaacaaaac taaataagga tggaacattt attgaatgaa aaatgcactt ttgtttttcc 360 attttttt 368 <210> 571 <211> 261 <212> DNA <213> Homo (Homo sapiens) <400> 571 acacgattgc tgcttccgct atatttgtga tataggaatt aagaggatac acacgtttgt 60 ttcttcgtgc ctgttttatg tgcacacatt aggcattgag acttcaagct tttctttttt 120 tgtccacgta tctttgggtc tttgataaag aaaagaatcc ctgttcattg taagcacttt 180 tacggggctg gtggggaggg gtgctctgct ggtcttcaat taccaagaat tctccaaaac 240 aattttctgc aggatgattg t 261 <210> 572 <211> 488 <212> DNA <213> Homo (Homo sapiens) <400> 572 ctctcagctc tcggcgcacg gcccagcttc cttcaaaatg tctactgttc acgaaatcct 60 gtgcaagctc agcttggagg gtgatcactc tacaccccca agtgcatatg ggtctgtcaa 120 agcctatact aactttgatg ctgagcggga tgctttgaac attgaaacag ccatcaagac 180 caaaggtgtg gatgaggtca ccattgtcaa cattttgacc aaccgcagca atgcacagag 240 acaggatatt gccttcgcct accagagaag gaccaaaaag gaacttgcat cagcactgaa 300 gtcagcctta tctggccacc tggagacggt gattttgggc ctattgaaga cacctgctca 360 gtatgacgct tctgagctaa aagcttccat gaaggggctg ggaaccgacg aggactctct 420 cattgagatc atctgctcca gaaccaacca ggagctgcag gaaattaaca gagtctacaa 480 ggaaatgt 488 <210> 573 <211> 619 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (619) <223> n = A, T, C or G <400> 573 actttactga aagaacacta ntgttctttc ctttccgttg tgaaaaaagt tgtttctgag 60 gaattgaaac cccagaagat aactacaaca aaaacatgtt aatttttttt taaaaatgat 120 gattcaaagg cagatttgaa gggaagtaat atttaggtgg cagaagaagg caaatgcagc 180 ctctgaaggg aactgttcta attattacct aaaaaataaa gttacacaac tatattcaag 240 gacatgagat aaagcactgc ttgaaaacca gaatgactga acagttaggt gaaaaggaac 300 agctgaaata ggaaggggaa atggactgaa gaataatttg aatcgggaca gtgatccatc 360 agtcctagat gcttctggta tgtaaatatc ttgaatcaca ttgtttcctt tcttctgaaa 420 tctcaaagga gaattctcac agcactacat taaggttgcc attttgttag gattcaaaat 480 ttcaatccag tagccatcag gatcttgaat aaatgccagg cctttcattt taccatcatc 540 aggtttcttc acaaatttga ctccagtctt caaccttttc aagcctgatc atcaggaaca 600 caattccata tgaccgatc 619 <210> 574 <211> 202 <212> DNA <213> Homo (Homo sapiens) <400> 574 acatccaccc cactatttct tcacataccg aatcaggatt gaaatgtcaa aagatgcact 60 tcctgagaag gcctgtcagt tggacagtcg ctattggaga ataacaaatg ctaagggtga 120 cgtggaagaa gttcaaggac ctggagtagt tggtgaattt ccaatcatca gcccaggtcg 180 ggtatatgaa tacacaagct gt 202 <210> 575 <211> 311 <212> DNA <213> Homo (Homo sapiens) <400> 575 ccacagttgt atcatatagc atctctaaca tttcatctag gattatctag tatagatctt 60 actatatttg ggactatgtt gtatacaatg ttaacaagaa catatcttct ctgcatatat 120 gtgtgaatta taaagaaaag catgagaatg actctaagtt caacaaacat gggtgaatct 180 ctatgtgctc ccagtgtcct ggatgggctc cccagcaagc cattcctcct tcctgttctg 240 atattactat tcttttttac attgtgctaa ggaggacaaa agatgagaga tgaaaataaa 300 gctttgcctt t 311 <210> 576 <211> 134 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (a) ... (134) <223> n = A, T, C or G <400> 576 ttttttgcat caaaaagctt tatttccatt tggnccaagg cttgttagga tagttaaaaa 60 agctgcctat tggctggagg ganaggctta ggcaaaancc ctattacttt gcaaggggcc 120 cttcaaaagt cgct 134 <210> 577 <211> 488 <212> DNA <213> Homo (Homo sapiens) <400> 577 ctgatcagtg ggcctccaag gaggggctgt aaaatggagg ccattgtgtg agcctatcag 60 agttgctgca aacctgaccc ctgctcagta aagcacttgc aaccgtctgt tatgctgtga 120 cacatggccc ctccccctgc caggagcttt ggacctaatc caagcatccc tttgcccaga 180 aagaagatgg gggaggaggc agtaataaaa agattgaagt attttgctgg aataagttca 240 aattcttctg aactcaaact gaggaatttc acctgtaaac ctgagtcgta cagaaagctg 300 cctggtatat ccaaaagctt tttattcctc ctgctcatat tgtgattctg cctttgggga 360 cttttcttaa accttcagtt atgatttttt tttcatacac ttattggaac tctgcttgat 420 ttttgcctct tccagtcttc ctgacacttt aattaccaac ctgttaccta ctttgacttt 480 ttgcattt 488 <210> 578 <211> 476 <212> DNA <213> Homo (Homo sapiens) <400> 578 accatgcatt aagagcttcc tgattgagat tcagtgcatc agccgtgtct attccatcta 60 cgtccacacc gtctgtgacc cactctttga agctgttggg aaaatattca gcaatgtccg 120 catcaacttg cagaaagaaa tataaatgac atttcaagga tagaagtata cctgattttt 180 ttccttttaa ttttcctggt gccaatttca agttccaagt tgctaataca gcaacaattt 240 atgaattgaa ttatcttggt tgaaaataaa aagatcactt tctcagtttt cataagtatt 300 atgtctcttc tgagctattt catctatttt tggcagtctg aatttttaaa acccatttaa 360 atttttttcc ttaccttttt atttgcatgt ggatcaacca tcgctttatt ggctgagata 420 tgaacatatt gttgaaaggt aatttgagag aaatatgaag aactgaggaa aaaaaa 476 <210> 579 <211> 246 <212> DNA <213> Homo (Homo sapiens) <400> 579 ctggtgctca ctgagatggt aggttttcct attttcctgc tacatctgca caagctacat 60 ctagaatgaa gccaccaatt tcaatgtgac caggcaatgg cagccagcac tgccttacac 120 tggtttgatt ctgattccct aattctggcc actgcaggtg atgagtaagg gtggggatca 180 gggaggaagt ccagaagcca gtctttgtct ccctttcctg cttatattta agtgcctatt 240 tacatg 246 <210> 580 <211> 615 <212> DNA <213> Homo (Homo sapiens) <220> <221> misc_feature <222> (1) ... (615) <223> n = A, T, C or G <400> 580 gtcttcacag taataactaa tggtggatcc taaggtgaaa ttatttcctt caaaatagnc 60 atgaactgna ttcccaggag ggncacagtc cctacttttg canatgggaa agggaggtgc 120 ccaggtgtgg tcctctagac actggctccg attgctgccc ttgaggatgt agtggtcatt 180 gcacataaac gtgattttgt cacttacatt cacaggccct gaagaactga actctccatt 240 caccagcaca ggatcaggac agtggcccaa gcggcactca gtagtggtgt tatcccactc 300 cttagaggca ttgcaaaaaa gggtcttctt tcctaccagg tggtagccct tgatacaaac 360 gtaagtcccc agaatctgtc cttccacctc ctttgcgaca aatatgctat tgtccactgg 420 aggaagctct ggacagtgct catctgaagc agaaactcgc cacgcaacca taagacagca 480 cgcacaccaa aaaaacatct ggtgatcaaa gtcctctccc caggctggaa ttcacccagc 540 tcagacacct tacctgtctc tgtccctcca gagttagggc ttcccancaa ggaactgggc 600 ttaactgact tccaa 615 <210> 581 <211> 576 <212> DNA <213> Homo (Homo sapiens) <400> 581 actcttgttg agttctgtag agccttctga tgtctctaaa gcactaccga ttctttggag 60 ttgtcacatc agataagaca tatctctaat tccatccata aatccagttc tactatggct 120 gagttctggt caaagaaaga aagtttagaa gctgagacac aaagggttgg gagctgatga 180 aactcacaaa tgatggtagg aagaagctct cgacaatacc cgttggcaag gagtctgcct 240 ccatgctgca gtgttcgagt ggattgtagg tgcaagatgg aaaggattgt aggtgcaagc 300 tgtccagaga aaagagtcct tgttccagcc ctattctgcc actcctgaca gggtgacctt 360 gggtatttgc aatattcctt tgggcctctg cttctctcac ctaaaaaaag agaattagat 420 tatattggtg gttctcagca agagaaggag tatgtgtcca atgctgcctt cccatgaatc 480 tgtctcccag ttatgaatca gtgggcagga taaactgaaa actcccattt acgtgtctga 540 atcgagtgag acaaaatttt agtccaaata acaagt 576 <210> 582 <211> 939 <212> DNA <213> Homo (Homo sapiens) <400> 582 atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat 60 gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg 120 cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg 180 gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc 240 aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct 300 gctccctccc agacatctgt gtacttctgt gccagcagtt actcagtcgg ggagggcggg 360 gattcacccc tccactttgg gaatgggacc aggctcactg tgacagagga cctgaacaag 420 gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag cagagatctc ccacacccaa 480 aaggccacac tggtgtgcct ggccacaggc ttcttccctg accacgtgga gctgagctgg 540 tgggtgaatg ggaaggaggt gcacagtggg gtcagcacgg acccgcagcc cctcaaggag 600 cagcccgccc tcaatgactc cagatactgc ctgagcagcc gcctgagggt ctcggccacc 660 ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc agttctacgg gctctcggag 720 aatgacgagt ggacccagga tagggccaaa cccgtcaccc agatcgtcag cgccgaggcc 780 tggggtagag cagactgtgg ctttacctcg gtgtcctacc agcaaggggt cctgtctgcc 840 accatcctct atgagatcct gctagggaag gccaccctgt atgctgtgct ggtcagcgcc 900 cttgtgttga tggccatggt caagagaaag gatttctga 939 <210> 583 <211> 828 <212> DNA <213> Homo (Homo sapiens) <400> 583 atgaactatt ctccaggctt agtatctctg atactcttac tgcttggaag aacccgtgga 60 aattcagtga cccagatgga agggccagtg actctctcag aagaggcctt cctgactata 120 aactgcacgt acacagccac aggataccct tcccttttct ggtatgtcca atatcctgga 180 gaaggtctac agctcctcct gaaagccacg aaggctgatg acaagggaag caacaaaggt 240 tttgaagcca cataccgtaa agaaaccact tctttccact tggagaaagg ctcagttcaa 300 gtgtcagact cagcggtgta cttctgtgct ccgaaccctt ctcttcaggg cggatctgaa 360 aagctggtct ttggaaaggg aacgaaactg acagtaaacc catatatcca gaaccctgac 420 cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc 480 gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac 540 aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc 600 aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc 660 ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca 720 gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa 780 gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctga 828 <210> 584 <211> 275 <212> PRT <213> Homo (Homo sapiens) <400> 584 Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly

5??????????????????10??????????????????15Arg?Thr?Arg?Gly?Asn?Ser?Val?Thr?Gln?Met?Glu?Gly?Pro?Val?Thr?Leu

20??????????????????25??????????????????30Ser?Glu?Glu?Ala?Phe?Leu?Thr?Ile?Asn?Cys?Thr?Tyr?Thr?Ala?Thr?Gly

35??????????????????40??????????????????45Tyr?Pro?Ser?Leu?Phe?Trp?Tyr?Val?Gln?Tyr?Pro?Gly?Glu?Gly?Leu?Gln

50??????????????????55??????????????????60Leu?Leu?Leu?Lys?Ala?Thr?Lys?Ala?Asp?Asp?Lys?Gly?Ser?Asn?Lys?Gly?65??????????????????70??????????????????75??????????????????80Phe?Glu?Ala?Thr?Tyr?Arg?Lys?Glu?Thr?Thr?Ser?Phe?His?Leu?Glu?Lys

85??????????????????90??????????????????95Gly?Ser?Val?Gln?Val?Ser?Asp?Ser?Ala?Val?Tyr?Phe?Cys?Ala?Pro?Asn

100?????????????????105?????????????????110Pro?Ser?Leu?Gln?Gly?Gly?Ser?Glu?Lys?Leu?Val?Phe?Gly?Lys?Gly?Thr

115?????????????????120?????????????????125Lys?Leu?Thr?Val?Asn?Pro?Tyr?Ile?Gln?Asn?Pro?Asp?Pro?Ala?Val?Tyr

130?????????????????135?????????????????140Gln?Leu?Arg?Asp?Ser?Lys?Ser?Ser?Asp?Lys?Ser?Val?Cys?Leu?Phe?Thr145?????????????????150?????????????????155?????????????????160Asp?Phe?Asp?Ser?Gln?Thr?Asn?Val?Ser?Gln?Ser?Lys?Asp?Ser?Asp?Val

165?????????????????170?????????????????175Tyr?Ile?Thr?Asp?Lys?Thr?Val?Leu?Asp?Met?Arg?Ser?Met?Asp?Phe?Lys

180?????????????????185?????????????????190Ser?Asn?Ser?Ala?Val?Ala?Trp?Ser?Asn?Lys?Ser?Asp?Phe?Ala?Cys?Ala

195?????????????????200?????????????????205Asn?Ala?Phe?Asn?Asn?Ser?Ile?Ile?Pro?Glu?Asp?Thr?Phe?Phe?Pro?Ser

210?????????????????215?????????????????220Pro?Glu?Ser?Ser?Cys?Asp?Val?Lys?Leu?Val?Glu?Lys?Ser?Phe?Glu?Thr225?????????????????230?????????????????235?????????????????240Asp?Thr?Asn?Leu?Asn?Phe?Gln?Asn?Leu?Ser?Val?Ile?Gly?Phe?Arg?Ile

245?????????????????250?????????????????255Leu?Leu?Leu?Lys?Val?Ala?Gly?Phe?Asn?Leu?Leu?Met?Thr?Leu?Arg?Leu

260?????????????????265?????????????????270Trp?Ser?Ser

275＜210〉585＜211〉312＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉585Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala

5??????????????????10??????????????????15Gly?Pro?Val?Asn?Ala?Gly?Val?Thr?Gln?Thr?Pro?Lys?Phe?Gln?Val?Leu

20??????????????????25??????????????????30Lys?Thr?Gly?Gln?Ser?Met?Thr?Leu?Gln?Cys?Ala?Gln?Asp?Met?Asn?His

35??????????????????40??????????????????45Glu?Tyr?Met?Ser?Trp?Tyr?Arg?Gln?Asp?Pro?Gly?Met?Gly?Leu?Arg?Leu

50??????????????????55??????????????????60Ile?His?Tyr?Ser?Val?Gly?Ala?Gly?Ile?Thr?Asp?Gln?Gly?Glu?Val?Pro?65??????????????????70??????????????????75??????????????????80Asn?Gly?Tyr?Asn?Val?Ser?Arg?Ser?Thr?Thr?Glu?Asp?Phe?Pro?Leu?Arg

85??????????????????90??????????????????95Leu?Leu?Ser?Ala?Ala?Pro?Ser?Gln?Thr?Ser?Val?Tyr?Phe?Cys?Ala?Ser

100?????????????????105?????????????????110Ser?Tyr?Ser?Val?Gly?Glu?Gly?Gly?Asp?Ser?Pro?Leu?His?Phe?Gly?Asn

115?????????????????120?????????????????125Gly?Thr?Arg?Leu?Thr?Val?Thr?Glu?Asp?Leu?Asn?Lys?Val?Phe?Pro?Pro

130?????????????????135?????????????????140Glu?Val?Ala?Val?Phe?Glu?Pro?Ser?Glu?Ala?Glu?Ile?Ser?His?Thr?Gln145?????????????????150?????????????????155?????????????????160Lys?Ala?Thr?Leu?Val?Cys?Leu?Ala?Thr?Gly?Phe?Phe?Pro?Asp?His?Val

165?????????????????170?????????????????175Glu?Leu?Ser?Trp?Trp?Val?Asn?Gly?Lys?Glu?Val?His?Ser?Gly?Val?Ser

180?????????????????185?????????????????190Thr?Asp?Pro?Gln?Pro?Leu?Lys?Glu?Gln?Pro?Ala?Leu?Asn?Asp?Ser?Arg

195?????????????????200?????????????????205Tyr?Cys?Leu?Ser?Ser?Arg?Leu?Arg?Val?Ser?Ala?Thr?Phe?Trp?Gln?Asn

210?????????????????215?????????????????220Pro?Arg?Asn?His?Phe?Arg?Cys?Gln?Val?Gln?Phe?Tyr?Gly?Leu?Ser?Glu225?????????????????230?????????????????235?????????????????240Asn?Asp?Glu?Trp?Thr?Gln?Asp?Arg?Ala?Lys?Pro?Val?Thr?Gln?Ile?Val

245?????????????????250?????????????????255Ser?Ala?Glu?Ala?Trp?Gly?Arg?Ala?Asp?Cys?Gly?Phe?Thr?Ser?Val?Ser

260?????????????????265?????????????????270Tyr?Gln?Gln?Gly?Val?Leu?Ser?Ala?Thr?Ile?Leu?Tyr?Glu?Ile?Leu?Leu

275?????????????????280?????????????????285Gly?Lys?Ala?Thr?Leu?Tyr?Ala?Val?Leu?Val?Ser?Ala?Leu?Val?Leu?Met

290 295 300Ala Met Val Lys Arg Lys Asp Phe305,310＜210〉586＜211〉97＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉586Glu Val Glu Val Ser Arg Asp His Ala Ser Leu Gly Asp Ser Glu Thr

5??????????????????10??????????????????15Leu?Ser?Gln?Thr?Glu?Leu?Arg?Lys?Lys?Glu?Arg?Lys?Lys?Lys?Arg?Glu

20??????????????????25??????????????????30Arg?Lys?Phe?Gln?Ala?Asn?Cys?Gly?Ile?Asp?Phe?Ile?Ile?Phe?Trp?Ile

35??????????????????40??????????????????45Phe?Trp?Ile?Leu?Leu?Phe?Ser?His?His?Trp?Ile?Gln?Glu?Ser?Leu?Leu

50?????????????????55?????????????????60Cys?Pro?Pro?Ser?Pro?Lys?Glu?Val?Thr?Cys?Arg?Glu?Met?Leu?Thr?Gly?65??????????????????70??????????????????75??????????????????80Gly?Cys?Leu?Pro?Trp?Ala?Thr?Arg?Ser?His?Leu?Gly?Arg?Arg?Lys?Cys

85 90 95Ser＜210〉587＜211〉16＜212〉PRT＜213〉homo sapiens (Homo sapiens)＜400〉587Phe Gln Ala Asn Cys Gly Ile Asp Phe Ile Ile Phe Trp Ile Ph Trp 15 10 15

Claims (17)

1. isolating polynucleotide, it comprises the sequence that is selected from down group:

(a) SEQ ID NO:390; 392,394,396,398-420,422-424, the sequence that 428-433 and 440-583 provide;

(b) SEQ ID NO:390,392,394,396,398-420,422-424,428-433 and 440-583 provide the complement of sequence;

(c) by SEQ ID NO:390,392,394,396,398-420,422-424,428-433 and 440-583 provide at least 20 of sequence the sequence that continuous residue is formed;

(d) under medium stringent condition, with SEQ ID NO:390,392,394,396,398-420,422-424,428-433 and 440-583 provide the sequence of sequence hybridization;

(e) with SEQ ID NO:390,392,394,396,398-420,422-424, the sequence of 428-433 and 440-583 has the sequence of at least 75% identity;

(f) with SEQ ID NO:390,392,394,396,398-420,422-424, the sequence of 428-433 and 440-583 has the sequence of at least 90% identity; With

(g) SEQ ID NO:390,392,394,396,398-420,422-424,428-433 and 440-583 provide the degeneracy varient of sequence.

2. isolated polypeptide, it comprises the aminoacid sequence that is selected from down group:

(a)SEQ?ID?NO：584-587；

(b) by the sequence of the polynucleotide encoding of claim 1; With

(c) has the sequence of at least 70% identity with sequence by the polynucleotide encoding of claim 1; With

(d) has the sequence of at least 90% identity with sequence by the polynucleotide encoding of claim 1.

3. expression vector, it comprises the polynucleotide of the claim 1 that can be operatively connected with expression regulation sequence.

4. with the expression vector conversion of claim 3 or the host cell of transfection.

5. specificity is in conjunction with the isolated antibody of the polypeptide of claim 2, or its Fab.

6. detect the patient and whether have method for cancer, may further comprise the steps:

(a) obtain biological specimen from the patient;

(b) make the polypeptide bonded wedding agent of biological specimen contact and claim 2;

(c) detect in the sample and wedding agent bonded polypeptide amount; With

(d) with the polypeptide amount and predetermined cutoff value compares and determine thus whether the patient exists cancer.

7. the fusion rotein that comprises the polypeptide of at least a claim 2.

8. under medium stringent condition, with SEQ ID N0:390,392,394,396,398-420,422-424, the oligonucleotide of the sequence hybridization that 428-433 and 440-583 quote.

9. stimulation and/or expansion are to the method for the specific T cell of oncoprotein, and being included in is enough to allow to stimulate and/or expand the condition of T cell and under the time, the T cell is contacted with at least a composition that is selected from down group:

(a) polypeptide of claim 2;

(b) polynucleotide of claim 1; With

(c) antigen presenting cell of the polypeptide of expression claim 2.

10. isolating T cell mass, it comprises the T cell according to the method preparation of claim 9.

11. composition, its comprise be selected from physiology can accept first composition of carrier and immunostimulant and be selected from down the group second composition:

(a) polypeptide of claim 2;

(b) polynucleotide of claim 1;

(c) antibody of claim 5;

(d) fusion rotein of claim 7;

(e) the T cell mass of claim 10; With

(f) antigen presenting cell of the polypeptide of expression claim 2.

12. stimulate the method for patient's immunne response, comprise the composition of using claim 11 to the patient.

13. treatment patient method for cancer comprises the composition of using claim 11 to the patient.

14. determine whether the patient exists method for cancer, may further comprise the steps:

(a) obtain biological specimen from the patient;

(b) make biological specimen contact the oligonucleotide of claim 8;

(c) detect in the sample amount with the polynucleotide of oligonucleotide hybridization; With

(d) will compare with the amount and the predetermined cutoff value of the polynucleotide of this oligonucleotide hybridization, and determine thus whether the patient exists cancer.

15. comprise the diagnostic kit of the oligonucleotide of at least a claim 8.

16. comprise the antibody of at least a claim 5 and the diagnostic kit of detection reagent, wherein detection reagent comprises reporter group.

17. suppress the method that patient's cancer takes place, may further comprise the steps:

(a) will and be selected from down at least a composition co-cultivation of organizing from isolating CD4+ of patient and/or CD8+T cell: (i) polypeptide of claim 2; The (ii) polynucleotide of claim 1; (iii) express the antigen presenting cell of the polypeptide of claim 2, make T cell proliferation;

(b) use the proliferative T cell of significant quantity to the patient,

And suppress the generation of patient's cancer thus.