CN1456202A - Medicines for treating oral leukoplakia and lichen ruber planus - Google Patents
Medicines for treating oral leukoplakia and lichen ruber planus Download PDFInfo
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- CN1456202A CN1456202A CN 03118146 CN03118146A CN1456202A CN 1456202 A CN1456202 A CN 1456202A CN 03118146 CN03118146 CN 03118146 CN 03118146 A CN03118146 A CN 03118146A CN 1456202 A CN1456202 A CN 1456202A
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Abstract
A Chinese medicine for treating oral leukoderma and oral lichen planus is prepared from 14 Chinese-medicinal materials including isatis root, houttuynia, plantain herb, dandelion herb, etc.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of oral leukoplakia and oral lichen planus, is the Chinese patent medicine of feedstock production specifically with the Chinese herbal medicine.
Background technology
Oral leukoplakia and oral lichen planus are the common disease and the frequently-occurring diseases in oral cavity.Oral leukoplakia is the white mucosa that oral mucosa can not be wiped, and is different from other white infringements.Oral lichen planus is a kind of with agnogenic chronic shallow keratinization pathological changes in the property inflammation, and is the same with its Peptic Ulcers of oral cavity Ah not, do not heal for a long time, repeatedly outbreak.Generally acknowledge that in the world oral leukoplakia and oral lichen planus are the oral mucosa precancerous lesion.Present Therapeutic Method mainly is to remove bad dummy in the oral cavity, pulls out oral cavity inner teeth gear undesirable root, unnecessary tooth, discontinues the habit of smoking and drinking, oral vitamin class medicine and left-handed rice azoles etc.These can only mitigate the disease, can not fundamentally cure, and the patient is lived in the misery for a long time.
Summary of the invention
The object of the present invention is to provide a kind of immunity that improves the human body body that has, enhancing body cell and humoral immune function, grow lung profit liver, promote the production of body fluid and seek liquid, blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, improve general body state and local blood circulation, promote epithelial repair, improve the oral leukoplakia of epithelium keratinization and the medicine of oral lichen planus.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to oral leukoplakia and oral lichen planus, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, taste lung profit liver, promote the production of body fluid and seek liquid, the body resistance strengthening and constitution consolidating, the homologous natural edible-plant medicine of medicated diet, by the theory of Chinese medical science prescription, skimming the cream off milk makes its performance promote epithelial repair, improves the epithelium keratinization, the effect of radical cure patient disease.
Medicine of the present invention is made (consumption is a weight portion) by following component:
15～25 parts of 20～25 portions of Herba Plantaginiss of Radix Isatidis 4 parts of Herba Houttuyniae of 20～25 parts of sharp shellfishes
1 part of 12 parts of LIUWEI DIHUANG TANG of 15～25 parts of JiaoShanZhis of 15～18 parts of Rhizoma Imperataes of Herba Taraxaci
10～15 parts on 10～15 parts of Flos Carthamis of 10～15 parts of Semen Persicaes of 10～15 parts of Radix agastachess of Flos Lonicerae
5～6 parts of 20～25 parts of Radixs Angelicae Dahuricae of Rhizoma Phragmitis
Preparing medicine optimum weight proportioning of the present invention is:
4 parts of 25 parts of sharp shellfishes of 25 portions of Herba Plantaginiss of 25 parts of Herba Houttuyniae of Radix Isatidis
15 parts of 1 part of Flos Lonicerae of 12 parts of LIUWEI DIHUANG TANG of 15 parts of JiaoShanZhis of Rhizoma Imperatae
20 parts of 12 parts of Rhizoma Phragmitiss of 12 parts of Flos Carthamis of 12 parts of Semen Persicaes of Radix agastaches
6 parts of 18 parts of Radixs Angelicae Dahuricae of Herba Taraxaci
The component of used LIUWEI DIHUANG TANG is as follows in the medicine of the present invention:
Not 15 parts of 15 parts of Job's tears of 15 parts of Cortex Moutans of the 15 portions of Rhizoma Alismatis in accurate mountain
15 parts of 15 parts of Fructus Cornis of Poria
Clinical drug of the present invention uses the result to show, has the following advantages:
1, to select the homologous natural food medicine of medicated diet for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function treatment oral leukoplakia and the oral lichen planus of the Chinese medicine of respectively distinguishing the flavor of, harmless.
2, the present invention makes simply, can be made into tablet, nine doses, also can decoct or be made into oral liquid voluntarily and directly drink.
3, light disease person can use separately, can unite use with transfer factor than serious symptom, and therapeutic effect obviously increases, and can alleviate or eliminate its disease, enhancing human body immunity power significantly.
For showing the therapeutic effect of medicine of the present invention to oral leukoplakia and oral lichen planus, the present invention is through the clinical observation of 320 routine systems, 120 routine oral leukoplakia patients, 200 routine oral lichen planus patients, by light, in, three types that weigh are divided into the oral leukoplakia treatment and organize 60 examples and matched group 60 examples, oral lichen planus treatment group 100 example and matched group 100 examples.Oral leukoplakia treatment group: every day oral medicine of the present invention, 2 times/day.Gently, the medium-sized state of an illness general course of treatment is 6 months, be 1 year the heavy course of treatment.The oral leukoplakia matched group: method is treated routinely, treatment time and treatment group are carried out synchronously, and be 6～12 months the general course of treatment, and oral lichen planus treatment group: every day, oral medicine of the present invention was 3 times/day, gently, the medium-sized state of an illness general course of treatment is 6 months, be 12 months the heavy course of treatment.The oral lichen planus matched group: also method is treated routinely, and treatment time and treatment group are imported and exported row synchronously, and be 6～12 months the general course of treatment.
Clinical test results is as showing:
Ig, C3 situation of change are relatively before and after the treatment of table 1 oral leukoplakia
Tabl?Ig?and?c
3?chinges?before?after?treatment?in?two?grups
Measurement result (g/L ± S)
The example number
IgG IgA IgM C
3Treat 60 11.63 ± 4.98 1.80 ± 0.63 1.59 ± 0.37 1.85 ± 0.39P value＜0.01＜0.01＞0.05＞0.05, preceding 60 15.70 ± 4.47 1.36 ± 0.55 1.66 ± 0.35 1.82 ± 0.35 treatment backs
Annotate: by to 25 routine oral leukoplakia patient immunoglobulin and C
3Measure to find there were significant differences before and after IgG, IgA treatment property (P＜0.01) IgM, C
3Do not see significant change (P＞0.05)
Table 2 oral leukoplakia treatment group and matched group physical data (X ± S)
The state of an illness
During example number men and women is light heavily treatment organize 60 examples, 14 16 10 26 24 matched group 60 examples, 17 13 16 28 6P value＞0.05＞0.05＞0.05＞0.05＞0.05 (wherein an example develops into cancer)
Ig, C before and after the treatment of table 3 oral lichen planus treatment group
3Situation of change relatively
Tab.3?Changes?of?Ig?and?C
3?pre-and?post-treatments
Measurement result (g/L ± S)
The example number
IgG IgA IgM C
3Treat preceding 100 7.65 ± 3.03 0.92 ± 0.29 1.18 ± 0.22 1.50 ± 0.32 treatment backs 100 12.25 ± 4.35 1.98 ± 0.51 1.19 ± 0.30 1.46 ± 0.38
P ＜0.01 ＜0.01 ＞0.05 ＞0.05
The treatment group is treated 50 routine patients, and IgG, IgA change highly significant (P＜0.01), IgM, C
3Do not see significant change (P＞0.05)
Table 4 oral lichen planus treatment group and matched group physical data (X ± S)
The state of an illness
During example number men and women is light heavily treatment organize 100 examples, 40 60 24 64 12 matched groups, 100 examples, 48 62 9 18 3P value＞0.05＞0.05＞0.05＞0.05＞0.05 (wherein two examples develop into cancer
One example is dead)
Pathology compare Tab.5 Comparision of pathological parameters between two groups pre and post treatment before and after the table 5 oral leukoplakia treatment group, treatment of control group
Cure the produce effects enabledisable
The example number
60 38 64 14 23 8 22 00 matched groups, 60 0000 40 67 20 33P value＜0.01＜0.01＜0.01＜0.01 are organized in n % n % n % n % treatment
Table 6 oral lichen planus treatment group, curative effect relatively after the treatment of control group
Tab.6?comparision?of?treatment?results?between?traditonal?Chinese?medicine?groudand?control?group
Cure the produce effects enabledisable
The example number
N % n % n % n % treatment is organized 100 80 80 16 16 4400 matched groups, 100 00 10 188 82 91P values＜0.01＜0.01＜0.01＜0.01 test statistics and shown: medicament of the present invention reaches 100% to the treatment effective percentage of oral leukoplakia and oral lichen planus.
Specific embodiment takes by weighing raw material by following proportioning: the accurate mountain of the sharp shellfish 4 gram Rhizoma Imperataes of Radix Isatidis 25 gram Herba Houttuyniae 25 gram Herba Plantaginiss 25 grams 15 gram JiaoShanZhis 12 gram Flos Lonicerae, 15 gram Radix agastachess, 12 gram Semen Persicaes, 12 gram Flos Carthamis, 12 gram Rhizoma Phragmitiss, 20 gram Herba Taraxacis, 18 grams 15 gram Rhizoma Alismatis, 15 gram Cortex Moutans, 15 gram Job's tears not 15 gram Fructus Cornis, the 15 gram Radixs Angelicae Dahuricae, 6 grams decoct into juice, and 2 times on the one oral.
Claims (3)
1. medicine for the treatment of oral leukoplakia and oral lichen planus, it is characterized in that: it is the medicament of being made by following materials of weight proportions:
15～25 parts of 20～25 portions of Herba Plantaginiss of Radix Isatidis 4 parts of Herba Houttuyniae of 20～25 parts of sharp shellfishes
1 part of 12 parts of LIUWEI DIHUANG TANG of 15～25 parts of JiaoShanZhis of 15～18 parts of Rhizoma Imperataes of Herba Taraxaci
10～15 parts on 10～15 parts of Flos Carthamis of 10～15 parts of Semen Persicaes of 10～15 parts of Radix agastachess of Flos Lonicerae
5～6 parts of 20～25 parts of Radixs Angelicae Dahuricae of Rhizoma Phragmitis
2. the medicine of treatment oral leukoplakia as claimed in claim 1 and oral lichen planus, wherein the weight proportion of each raw material is:
4 parts of 25 parts of sharp shellfishes of 25 portions of Herba Plantaginiss of 25 parts of Herba Houttuyniae of Radix Isatidis
15 parts of 1 part of Flos Lonicerae of 12 parts of LIUWEI DIHUANG TANG of 15 parts of JiaoShanZhis of Rhizoma Imperatae
20 parts of 12 parts of Rhizoma Phragmitiss of 12 parts of Flos Carthamis of 12 parts of Semen Persicaes of Radix agastaches
6 parts of 18 parts of Radixs Angelicae Dahuricae of Herba Taraxaci
3. the treatment oral leukoplakia described in claim 1 or 2 and the medicine of oral lichen planus, the component of wherein used LIUWEI DIHUANG TANG is as follows:
Not 15 parts of 15 parts of Job's tears of 15 parts of Cortex Moutans of the 15 portions of Rhizoma Alismatis in accurate mountain
15 parts of 15 parts of Fructus Cornis of Poria
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03118146 CN1456202A (en) | 2003-03-06 | 2003-03-06 | Medicines for treating oral leukoplakia and lichen ruber planus |
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| CN 03118146 CN1456202A (en) | 2003-03-06 | 2003-03-06 | Medicines for treating oral leukoplakia and lichen ruber planus |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100406046C (en) * | 2006-06-23 | 2008-07-30 | 陈文渊 | Medicine for treating oral lichen planus |
| WO2008139487A1 (en) * | 2007-05-10 | 2008-11-20 | Rajesh Shah | Homeopathy-based formulation |
| CN103272145A (en) * | 2013-05-29 | 2013-09-04 | 青岛市市立医院 | Traditional Chinese medicinal composition for treating oral lichen planus and application |
| CN104606314A (en) * | 2015-03-04 | 2015-05-13 | 马宁 | Traditional Chinese medicine for treating oral lichen planus and preparation method thereof |
| CN104800562A (en) * | 2015-05-06 | 2015-07-29 | 青岛市口腔医院 | Traditional Chinese medicine composition for treating oral lichen planus and preparation method thereof |
-
2003
- 2003-03-06 CN CN 03118146 patent/CN1456202A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100406046C (en) * | 2006-06-23 | 2008-07-30 | 陈文渊 | Medicine for treating oral lichen planus |
| WO2008139487A1 (en) * | 2007-05-10 | 2008-11-20 | Rajesh Shah | Homeopathy-based formulation |
| US8163308B2 (en) | 2007-05-10 | 2012-04-24 | Rajesh Shah | Homeopathy-based formulation |
| CN103272145A (en) * | 2013-05-29 | 2013-09-04 | 青岛市市立医院 | Traditional Chinese medicinal composition for treating oral lichen planus and application |
| CN103272145B (en) * | 2013-05-29 | 2015-07-15 | 卢恕来 | Traditional Chinese medicinal composition for treating oral lichen planus and application |
| CN104606314A (en) * | 2015-03-04 | 2015-05-13 | 马宁 | Traditional Chinese medicine for treating oral lichen planus and preparation method thereof |
| CN104800562A (en) * | 2015-05-06 | 2015-07-29 | 青岛市口腔医院 | Traditional Chinese medicine composition for treating oral lichen planus and preparation method thereof |
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