CN1443544A

CN1443544A - Chinese medicine Jiangtang Tongmailing for curing diabetes and preventing and curing complicating diseases and its preparation method

Info

Publication number: CN1443544A
Application number: CN 02104038
Authority: CN
Inventors: 张世均
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-03-07
Filing date: 2002-03-07
Publication date: 2003-09-24

Abstract

The present invention discloses a pure Chinese medicine compound preparation for curing diabetes and preventing and curing its complicating diseases and its preparation method. It is formed from 14 Chinese medicinal materials of ginseng, astragalus root, pseudostellaria root, polygonatum root, Chinese yam, pueraria root and others. Said Chinese medicine compound preparation is mainly used for curing non-insulin-dependent diabetes and its complicating diseases of diabetic angiocardiopathy, diabetic cerebrovascular diseases, diabetic nephrosis, diabetic acromelic angiopathy and diabetic ophthalmopathy, etc. Its total effective rate for reducing sugar is 97%.

Description

A kind of Chinese medicine Jiangtang Tongmailing and preparation method for the treatment of diabetes and preventing and treating complication

The invention discloses a kind of pure Chinese medicine compound for the treatment of diabetes and preventing and treating complication, belong to the Chinese medicine blood sugar lowering.

Along with the change of growth in the living standard, life pattern, the enhancing of social senilization and self health consciousness, the sickness rate of diabetes increases year by year.China's onset diabetes rate eighties in 20th century is 1%, rises to 5% at present, and number of the infected is increased to 5,000 ten thousand by 6,000,000.Because Diabetes Mellitus Knowledge and treatment level differ, in addition type 2 diabetes mellitus patient early symptom gently, how to seek medical advice from evening, What is more does not monitor blood glucose for a long time, it is inadequate to control, have patient's course of disease of nearly 1/2 entered in, late period, most of patients suffers from complication in various degree, as: diabetic angiopathies such as diabetic hypertension, diabetes hyperlipidemia.Yet, the massive epidemiology data shows, diabetes only account for 3-5% because of hyperglycemia causes acute ketoacidosis death, and because of the acute and chronic complication of diabetes, causing death, disable as diabetic cardiovascular disease, diabetic cerebrovascular disease, diabetic nephropathy, diabetes extremity vascular disease, diabetic ophthalmopathy etc. but accounts for 75-90%.A large amount of clinical datas show that also diabetes are only used oral western medicine and insulinize, and curative effect is often not ideal enough.Hyperglycemia is not to cause unique factor of complication, and simple blood sugar lowering can delay the part complication but can not prevent and treat many vascular complications.Western medicine has advantages such as blood sugar lowering is rapid, dosage form is advanced, practicality, also exists the hypoglycemic medicine of chemosynthesis that toxic and side effects such as gastrointestinal reaction, erythra, hepatic injury are arranged more, is not suitable for taking for a long time, and especially liver, renal insufficiency person Ying Shen use so that forbidding.So far also do not find on the diabetic complication in control and a kind ofly can blood sugar lowering can prevent and treat the diabetes multiple complications again and do not have the medicine of toxic and side effects.The present invention seeks to utilize the natural Chinese medicinal herb blood sugar lowering can prevent and treat multiple complications simultaneously, and have no side effect, be fit to take for a long time, use no or little Western medicine, to improve the existence and the quality of life of diabetics.

The present invention is achieved in that by Radix Ginseng, Radix Astragali, Radix Pseudostellariae, Rhizoma Polygonati, Radix Trichosanthis, the Radix Rehmanniae, Radix Ophiopogonis, Kaifeng Rhizoma Dioscoreae, Radix Puerariae, Radix Scrophulariae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Cyathulae and forms Jiangtang Tongmailing.In the side: Radix Ginseng, the Radix Astragali, Rhizoma Polygonati, Kaifeng Rhizoma Dioscoreae Yiqiyangyuan; Radix Trichosanthis, Radix Ophiopogonis, the Radix Rehmanniae, Radix Scrophulariae, Fructus Schisandrae Chinensis yin nourishing spermatogenesis; Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae, Radix Cyathulae blood circulation and channel invigorating; All medicines share, and strengthening the body resistance is arranged, mend to transfer the five internal organs, supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, blood circulation promoting and blood stasis dispelling, the merit of comb through promoting blood circulation, up to standard, this, the disease of the holding concurrently effect of ruling together.The present invention cures mainly type 2 diabetes mellitus, to intense heat due to deficiency of YIN type of initial phase of diabetes, mid-term type of deficiency of both QI and YIN, late period the deficiency of both YIN and YANG type all have blood sugar lowering definite, stable, especially to control diabetic cardiovascular disease, diabetic cerebrovascular disease, diabetic nephropathy, diabetes acral angiopathy, diabetic neuropathy, diabetic ophthalmopathy, and early treatment can make early lesion reverse, in, can obviously improve symptom late period, the generation and the development of prevention and control complications.Through long-term clinical verification, the blood sugar lowering total effective rate is 97%, and blood pressure lowering total effective rate 90%, blood fat reducing total effective rate are 91%, are 79～98% to complication doing well,improving rate.Be fit to type 2 diabetes mellitus patient blood sugar control, prevent and treat complication and take for a long time, also can be used for type 1 diabetes and prevent and treat complication and take for a long time, and without any side effects.

Modern pharmacological research proves: Radix Ginseng in the side, the Radix Astragali, Radix Pseudostellariae, the Radix Rehmanniae, Radix Trichosanthis, Rhizoma Polygonati, Radix Ophiopogonis, Fructus Schisandrae Chinensis have the beta Cell of islet of improvement function, promote insulin secretion, suppress pancreas and give birth to the plain secretion of sugar, improve insulin sensitivity, remarkable hypoglycemic activity is arranged; Radix Ginseng, the Radix Astragali have the increase body's immunity; The Radix Astragali also has dual regulation to blood glucose; Radix Pseudostellariae, the Radix Rehmanniae, Rhizoma Polygonati, Rhizoma Dioscoreae have good regulating action to endocrine and metabolic disorders; Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Puerariae, the Radix Astragali, Radix Achyranthis Bidentatae can improve the blood vessel blood supply, prevent platelet aggregation, blood viscosity lowering, microcirculation improvement, significant blood sugar lowering, blood fat reducing, blood pressure regulation, the effect of minimizing albuminuria are arranged.Full side's blood sugar reducing function obviously, reliable, blood fat reducing, blood pressure regulation, reduction albuminuria are remarkable, it is distinguished to prevent and treat multiple complications.

The percentage by weight that the invention is characterized in all flavor Chinese medicine is respectively Radix Ginseng 0～10%, Radix Astragali 10～30%, Radix Pseudostellariae 5～15%, Rhizoma Polygonati 10～15%, Radix Trichosanthis 10～15%, Radix Rehmanniae 10～15%, Radix Ophiopogonis 5～10%, Kaifeng Rhizoma Dioscoreae 10～15%, Radix Puerariae 5～10%, Radix Scrophulariae 0～15%, Fructus Schisandrae Chinensis 5～10%, Radix Salviae Miltiorrhizae 10～15%, Rhizoma Chuanxiong 0～10%, Radix Cyathulae 5～10%.

The invention is characterized in that it prepares in order to the below method, with above prescription take by weighing by weight percentage Chinese herbal medicine routinely cleaning pulverized 80～100 orders, soak with 5～10 times of ethanol waters to crude drug weight, concentration of alcohol is 25%～75%, soaks 1～4 hour, invade and carry 1～4 time, and stir at a high speed, invade the temperature raising degree in room temperature～60 ℃, invade extract and filter the back respectively and merge, reclaim ethanol, concentrated solution is made fine powder with spray drying or lyophilization.Also available conventional formulation technology, the adjuvant that can add necessary relevant dosage form is prepared into the pharmaceutical preparation that any suitable diabetes patient uses, as: pill, electuary, powder, medicinal tea, tablet, oral solutions, capsule get product.

Non-limiting optimal way embodiment is described below:

Get 4 kilograms of Radix Ginsengs, 12 kilograms of Radix Astragali, 6 kilograms of Radix Pseudostellariaes, 12 kilograms of Rhizoma Polygonatis, 12 kilograms of Radix Trichosanthis, 12 kilograms in the Radix Rehmanniae, 6 kilograms of Radix Ophiopogonis, 12 kilograms of Kaifeng Rhizoma Dioscoreaes, 6 kilograms of Radix Puerariaes, 3 kilograms of Radix Scrophulariaes, 6 kilograms of Fructus Schisandrae Chinensis, 15 kilograms of Radix Salviae Miltiorrhizaes, 8 kilograms of Rhizoma Chuanxiongs, 6 kilograms of decoction pieces of Radix Cyathulae mix, dry, pulverize, cross 100 orders, soaked 60 minutes for 1200 liters with 70% ethanol water, and at a high speed to stir after-filtration be A liquid, reuse 30% ethanol water soaked 60 minutes, and the high-speed stirred after-filtration is a B liquid, with A liquid, B liquid merges through stirring after-filtration at a high speed, ethanol is reclaimed in filter, it is semi-finished product that spray-dried or lyophilization system is ground into fine powder, gets product towards filling out No. 1 100,000 of capsule.

Claims

1 one kinds of pure Chinese medicine compound for the treatment of diabetes and preventing and treating complication is characterized in that being made up of Radix Ginseng, Radix Pseudostellariae, the Radix Astragali, Rhizoma Polygonati, Radix Trichosanthis, the Radix Rehmanniae, Radix Ophiopogonis, Rhizoma Dioscoreae, Pueraria lobota ginseng, Radix Scrophulariae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae 14 flavor Chinese medicines;

2 according to claim 1 described compound recipe, it is characterized in that the percentage by weight of all flavor Chinese medicine is: Radix Ginseng 0～10%, Radix Pseudostellariae 5～15%, Radix Astragali 10～30%, Rhizoma Polygonati 10～15%, Radix Trichosanthis 10～15%, the Radix Rehmanniae 10～15%, Radix Ophiopogonis 5～10%, Rhizoma Dioscoreae 10～15%, Radix Puerariae 5～10%, Fructus Schisandrae Chinensis 5～10%, Radix Scrophulariae 0～15%, Radix Salviae Miltiorrhizae 10～15%, Rhizoma Chuanxiong 0～10%, Radix Achyranthis Bidentatae 5～10%;

3 according to the described a kind of treatment diabetes of claim 1 and the preparation method of preventing and treating the complication compound recipe, it is characterized in that Chinese crude drug need dry, pulverize 80～100 orders, with 25～75% ethanol waters invade carry 1～4 time, invade that the temperature raising degree is controlled at room temperature～65 ℃, filters that the back merges respectively, be ground into fine powder behind the recovery ethanol, cold drying.

4 according to claim 1 described a kind of treatment diabetes and prevent and treat the complication compound recipe, it is characterized in that available conventional formulation technology, the adjuvant that can add necessary relevant dosage form is made and is suitable for diabetic to take pill, electuary, powder, medicinal tea, tablet, oral solutions, capsule.