CN1428155A - Medicine for curing cervical spondylopathy - Google Patents
Medicine for curing cervical spondylopathy Download PDFInfo
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- CN1428155A CN1428155A CN01137203A CN01137203A CN1428155A CN 1428155 A CN1428155 A CN 1428155A CN 01137203 A CN01137203 A CN 01137203A CN 01137203 A CN01137203 A CN 01137203A CN 1428155 A CN1428155 A CN 1428155A
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Abstract
The present invention relates to a Chinese medicine for curing cervical spondylopathy. Said Chinese medicine is made up by using 10 Chinese medicinal materials of krait/agkistrodon, cibotium root, amber, cinnamon twig, salvia root and others through a certain preparation process, and said medicine has the effect of promoting blood circulation, removing stasis and freeing the channels and network vessels, and can obtain obvious therapeutic effect for curing cervical spondylopathy.
Description
Cervical spondylosis claims cervical vertebra syndrome again, is because the cervical intervertebral disk degenerative changes caused a series of symptom, and clinical manifestation is dizzy and symptomes complices such as neck, shoulder, arm, hands pain, numbness.
This is a kind of commonly encountered diseases, frequently-occurring disease, the multiple age is in 30-50 year, a young and middle-aged in recent years patient is also in rising trend, but in the treatment patient, 9 years old~13 years old juvenile student is also arranged, thereby they cause cervical spondylosis owing to quarrelling and fighting noisily to cause injury, person between twenty and fifty are again because of bending over one's desk working for a long time, as accounting, editor's etc. about 30 years old woman, their sickness rate is more than 95%.
The cause of disease of cervical spondylosis, endogenous cause of ill are 1. 2. caused by liver and kidney deficiency of congenital malformation.Exopathogenic factor is because of acute cervical spinal injury, chronic strain, and the acute inflammation around the wind-cold damp pathogen, neck all can cause the generation of primary disease.
Chinese medicine thinks that the skeleton of suffering from a deficiency of the kidney loses supports, gas, blood, expectorant, arthralgia due to blood stasis resistance passages through which vital energy circulates.The skeleton of suffering from a deficiency of the kidney then loses in moistening foster, gives birth in the hyperosteogeny, causes injury of tendon and muscle flesh and decreases, and of a specified duration is blood-stasis internal-depression; Second blood operation in Tianjin is unable, and stopping coacervation is phlegm-turbidity and blood stasis blood, the obstruction of meridian circulation, and dignified with the passing of time hyperosteogeny is living.Primary disease is levying of deficiency in origin and excess in superficiality, die and consolidate it with the kidney invigorating, control its mark with blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, and as the principles of formulating prescriptions, formed " a kind of medicine for the treatment of cervical spondylosis ", clinical observation shows that this medicine is all effective to each myelopathy, and is more outstanding to spondylotic radiculopathy, vertebral artery type, adrenergic type, mixed type curative effect especially.Rhizoma Cibotii bitter in the mouth, sweet, warm is returned the Liver and kidney warp in the side, " book on Chinese herbal medicine justice ": " can the replenishing vital QI with drugs of warm nature Liver and kidney, logical hundred arteries and veins of transferring, strong waist sunset, hard spine, sharp joint, and drive the numbness work, it is useless to play flaccidity, again can astringency inducing dashes to stagnate, and strong superintending and directing appointed, and effect is very grand, really the product used of weak old and feeble perseverance.And temperature and not dry is walked and is not let out, and particularly has every advantage and not a single disadvantage, not to attach most importance to, very unfortunately also." book on Chinese herbal medicine through vegetables ": " Rhizoma Cibotii, bitter can dampness, the beneficial blood of sweet energy, temperature can be fostered the spirit of nobility, be mend and the medicine that can walk also.Suffering from a deficiency of the kidney, then the back is strong, and there is the disease of emergency in office, the nourishing kidney replenishing QI and blood, and then the back is not strong, the trouble of the no emergency of office.So I in the treating cervical spondylosis prescription, reuse Rhizoma Cibotii with dispelling wind and relieving pain, mending the strong waist of bone is principal agent.Agkistrodon sweet in the mouth, salty, warm in the side, the poisonous Liver Channel of returning.This moral character is apt to away scurry, in walk internal organs, infuse fur outward, nowhere less than, can search ailment said due to cold or exposure, saturating joint is used for wind chill blockage more, limbs pain, joint is unfavorable, the stupid numb disease of muscle is equipped with Semen Strychni (processed), Scolopendra, principal agent in the channels sootheing and network vessel quickening side of being again.Be equipped with the Ramulus Cinnamomi qi and blood circulation promotion in the side, stimulate the menstrual flow end; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling; Radix Puerariae is with controlling stiff nape and back; " medicine justice ": " Radix Clematidis: property is fierce, and lid is walked and do not kept, and the logical twelve channels and collaterals of a surname cures mainly wind, wet, expectorant, heap soil or fertilizer over and around the roots and stagnates in the meridians, causes into the gout migratory arthralgia caused by wind, and arthralgia is swollen or numb, because of its power violent, also can cartilage.Rhizoma Drynariae, the continuous muscle of the kidney invigorating pain relieving is cured the wound.Full side's compatibility, also invigorating the liver and kidney is consolidated it, the meridian dredging that relaxes again, blood circulation promoting and blood stasis dispelling is controlled its mark, so the treatment cervical spondylosis is had significant curative effect.
Therefore, medicine of the present invention is to be the Chinese patent medicine that feedstock production forms with following pharmaceutical composition.
Agkistrodon 100-200 gram, Rhizoma Cibotii 100-200 gram, succinum 30-50 gram, Ramulus Cinnamomi 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Radix Clematidis 30-50 gram, Radix Puerariae 30-50 gram, Rhizoma Drynariae 30-50 gram, Scolopendra 30-50 gram, Semen Strychni (processed) 30-50 restrains (weight portion)
The preferred weight proportioning of pharmaceutical composition of the present invention is:
Agkistrodon 100, Rhizoma Cibotii 100, succinum 30, Ramulus Cinnamomi 30, Radix Salviae Miltiorrhizae 30, Radix Clematidis 30, Radix Puerariae 30, Rhizoma Drynariae 30, Scolopendra 30, Semen Strychni (processed) 30 (weight portion)
Pharmaceutical composition of the present invention according to conventional formulation technology, can be prepared into any pharmaceutical preparation that is suitable for using clinically.For example: pill, tablet, powder, capsule, a material agent any.
Pharmaceutical composition of the present invention can directly prepare patent medicine, also can extract respectively each group of compositions, prepares patent medicine then, and these are all within protection scope of the present invention.
Process for preparing medicine of the present invention is:
1 selected crude drug: selected high-quality Chinese crude drug, remove impurity, differentiate and the run-of-the-mill check that by pharmacopeia regulation defective medical material such as of poor quality, as to go bad, damage by worms, go mouldy must not use.
2 polish: with Agkistrodon; Rhizoma Cibotii; Ramulus Cinnamomi; Radix Salviae Miltiorrhizae; Radix Clematidis; Radix Puerariae; Rhizoma Drynariae; Scolopendra; Semen Strychni (processed) adds 8 times of water loggings or does not have powder 2-3cm; heating decocts 2 hours after-filtration; the medicine short, bristly hair or beard adds 4 times of amounts of water; heating for the second time decocts and filtered in 1 hour again; the merging filtrate low-temperature evaporation; be concentrated into half amount of original volume; adding 95% ethanol equivalent mixing spends the night and makes sedimentation; the supernatant that inclines steams to slip and reclaims ethanol, and revaporization concentrates; putting cold place filtered precipitation in 24 hours fully; the filtrate low-temperature evaporation is to flute honey shape (water content 20%), and succinum is ground into powder and is blended into, and adds an amount of excipient mixing; make soft material with 70% ethanol; move to granulation machine 12 orders and granulate, put in the baking oven dry again under the low temperature, encapsulated standby (per 1 gram contains crude drug 2 grams).
Pharmaceutical composition of the present invention has liver and kidney tonifying, blood circulation promoting and blood stasis dispelling, and the effect of the meridian dredging that relaxes, especially to spondylotic radiculopathy, vertebral artery type, adrenergic type, mixed type cervical spondylosis curative effect is comparatively outstanding.
Clinical research:
1, physical data: 100 examples are organized in treatment, matched group 100 examples.Sex and age treatment group: male's 60 examples, women's 40 examples.10 examples below 40 years old, 40-50 year 50 examples, 50-60 year 30 examples, 60-70 year 10 examples, the course of disease is the longest 20 years, the shortest person 3 months.Pathology typing: spondylotic radiculopathy 50 examples, vertebral artery type 30 examples, adrenergic type 10 examples, mixed type 10 examples.
The Chinese medical discrimination typing: wind and cold wet type 30 examples, qi stagnation and blood stasis type 20 examples are talked wet resistance network type 10 examples, deficiency of the liver and kindey type 20 examples, deficiency of qi and blood type 20 examples.
Matched group: 100 examples, male 60 examples, women 40 examples; 9 examples below 40 years old, 40-50 year 50 examples, 50-60 example 25 examples, 60-70 year 16 examples; The course of disease is the longest 18 years, and is the shortest 5 months;
Pathology typing: spondylotic radiculopathy 20 examples, vertebral artery type 20 examples, adrenergic type 50 examples, mixed type 10 examples, Chinese medical discrimination typing: wind and cold wet type 20 examples, qi stagnation and blood stasis type 20 examples, phlegm-damp resistance network type 30 examples.Deficiency of the liver and kindey type 30 examples.
All case all meets in " Chinese medical discrimination diagnosis criterion of therapeutical effect " (1), about the diagnostic criteria of cervical spondylosis.
2, Therapeutic Method: the treatment group is taken " a kind of medicine for the treatment of cervical spondylosis ", and each 3, every 0.5 gram, day 3 times.Matched group is taken ZHUANGGU GUANJIE WAN (southern pharmaceutical factory produce) every day 2 times, and each 10 grams are all taken 3 months post-evaluation curative effects for two groups continuously.
3, result:
3.1 criterion of therapeutical effect: formulate with reference to " the clinical disease rash is disconnected according to curing the improvement standard ".
3.2 therapeutic outcome: the treatment group is cured 40 examples (40%), 50 examples that take a turn for the better (50%), invalid 10 examples (10%), total effective rate 90%;
Matched group is cured 7 examples (7%), 27 examples that take a turn for the better (27%), invalid 66 examples (66%), total effective rate (34%).
Relatively there were significant differences (P<0.01) for two groups of total effective rates
Two groups of each pathology typings relatively see Table 1
Table 1 liang group different pathological pattern of syndrome curative effect
Pattern of syndrome | Group | ????N | Cure | Take a turn for the better | Invalid | Effective percentage (%) |
Spondylotic radiculopathy | The treatment group | ????50 | ????20 | ????27 | ????3 | ????94% |
Matched group | ????20 | ????3 | ????4 | ????13 | ????35% | |
Vertebral artery type | The treatment group | ????30 | ????10 | ????16 | ????4 | ????86.7% |
Matched group | ????20 | ????2 | ????4 | ????14 | ????30% | |
Adrenergic type | The treatment group | ????10 | ????5 | ????4 | ????1 | ????90% |
Matched group | ????50 | ????1 | ????17 | ????32 | ????36% | |
Mixed type | The treatment group | ????10 | ????5 | ????3 | ????2 | ????80% |
Matched group | ????10 | ????1 | ????2 | ????7 | ????30% |
Annotate: compare ※ P<0.05 ※ ※ P<0.01 with matched group
Experimentation:
One, experiment material is got 20 of healthy rabbits, behind the labelling of weighing, is divided into treatment group and matched group at random, every group of 10 white rabbits.
Two, experimental technique: the rabbit knee joint is carried out 90 degree stretch a formula and fix, stretched fixedly the person 40 days, early stage hyperosteogeny forms and the cartilage degeneration, rabbit model, wherein treatment group, with a kind of medicine for the treatment of cervical spondylosis, gavage 3, every day 3 times at every turn, matched group gavages ZHUANGGU GUANJIE WAN, each 10 grams, day 2 times, two groups was a course of treatment with 3 months all.
Three, experimental result: a kind of medicine for the treatment of cervical spondylosis, the treatment group: after gavaging 3 months, clinic control, hyperosteogeny disappears softening, and painful fiber crops recover to reach 91%.ZHUANGGU GUANJIE WAN, matched group faces the painful fiber crops of control after gavaging 3 months and reaches 80%.A kind of medication therapy groups and matched group for the treatment of cervical spondylosis all can obviously alleviate the control clinical symptoms, but treatment group curative effect is better than matched group.P<0.05。
Embodiment: Agkistrodon 100, Rhizoma Cibotii 100, Ramulus Cinnamomi 30, succinum 30, Radix Salviae Miltiorrhizae 30, Radix Clematidis 30, Radix Puerariae 30, Rhizoma Drynariae 30, Scolopendra 30, Semen Strychni (processed) 30 (weight portion)
Technology:
Defective medical materials such as 1, selected crude drug: selected high-quality Chinese crude drug is removed impurity, and differentiates and the run-of-the-mill check by the pharmacopeia regulation, and is of poor quality, as to go bad, go mouldy must not use.
2; polish: with Agkistrodon; Rhizoma Cibotii; Ramulus Cinnamomi; Radix Salviae Miltiorrhizae; Radix Clematidis; Radix Puerariae; Rhizoma Drynariae; Scolopendra; Semen Strychni (processed); add 8 times of water loggings or do not have powder 2-3cm; heating decocts 2 hours after-filtration; medicinal residues add 4 times of amounts of water, 1 hour after-filtration of heating decoction for the second time again; the merging filtrate low-temperature evaporation; be concentrated to half amount of original volume; adding 95% ethanol equivalent mixing spends the night and makes sedimentation; the supernatant that inclines steams to slip and reclaims ethanol; revaporization concentrates, and puts cold place and precipitation is filtered fully in 24 hours, and the filtrate low-temperature evaporation is to thick sweet shape (water content 20%); succinum is ground into powder and is blended into; add an amount of excipient mixing, make soft material with 70% ethanol, dislocation granulation machine 12 orders are granulated; put that the drying cartridge capsule is standby again under the low temperature in the baking oven, adorn 0.5 gram (every gram contains crude drug 2 grams) for every
Claims (3)
1, a kind of pure Chinese medicinal preparation " a kind of medicine for the treatment of cervical spondylosis " for the treatment of cervical spondylosis.
It is characterized in that the medicament that is prepared from according to following proportioning with Agkistrodon and Rhizoma Cibotii, succinum and Ramulus Cinnamomi, Radix Salviae Miltiorrhizae and Radix Clematidis, Radix Puerariae and Rhizoma Drynariae, Scolopendra and Semen Strychni (processed).
Agkistrodon 100-200 gram, Rhizoma Cibotii 100-200 gram, succinum 30-50 gram, Ramulus Cinnamomi 30-50 gram, Radix Salviae Miltiorrhizae 30-50 gram, Radix Clematidis 30-50 gram, Radix Puerariae 30-50 gram, Rhizoma Drynariae 30-50 gram, Scolopendra 30-50 gram, Semen Strychni (processed) 30-50 restrains (weight portion).
2, according to right 1 described Chinese medicine, it is characterized in that Agkistrodon and Rhizoma Cibotii, succinum and Ramulus Cinnamomi, Radix Salviae Miltiorrhizae and Radix Clematidis, Radix Puerariae and Rhizoma Drynariae, the proportioning of Scolopendra and Semen Strychni (processed) is:
Agkistrodon 100, Rhizoma Cibotii 100, succinum 30, Ramulus Cinnamomi 30, Radix Salviae Miltiorrhizae 30, Radix Clematidis 30, Radix Puerariae 30, Rhizoma Drynariae 30, Scolopendra 30, Semen Strychni (processed) 30 (weight portion).
3, according to the Chinese medicine of claim 1 or 10, the dosage form that it is characterized in that this medicine is any of pill, tablet, powder, capsule, granule.
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CNB011372036A CN1212852C (en) | 2001-10-20 | 2001-10-20 | Medicine for curing cervical spondylopathy |
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CNB011372036A CN1212852C (en) | 2001-10-20 | 2001-10-20 | Medicine for curing cervical spondylopathy |
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CN101862431B (en) * | 2009-04-20 | 2011-11-23 | 赵宗仙 | Chinese medicinal composition for treating vertebral arterial type of cervicalspondylosis by Chinese medicament fumigation |
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CN100339095C (en) * | 2005-08-25 | 2007-09-26 | 贺拴友 | Cervical spondylosis treating Chinese medicine composition |
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CN101862431B (en) * | 2009-04-20 | 2011-11-23 | 赵宗仙 | Chinese medicinal composition for treating vertebral arterial type of cervicalspondylosis by Chinese medicament fumigation |
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