CN1416848A - Capsule for treating chronic hepatitis B and its prepn - Google Patents
Capsule for treating chronic hepatitis B and its prepn Download PDFInfo
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- CN1416848A CN1416848A CN 01133609 CN01133609A CN1416848A CN 1416848 A CN1416848 A CN 1416848A CN 01133609 CN01133609 CN 01133609 CN 01133609 A CN01133609 A CN 01133609A CN 1416848 A CN1416848 A CN 1416848A
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Abstract
The present invention relates to medicine prepared with plant material and its preparation process. Prepared rhizome of rehmannia, prepared fleeceflower root, wolfberry fruit, curcuma root, red sage and other over ten kinds of Chinese medicinal materials as well as some supplementary material are produced to the capsule mixing, drying, crushing, sieving, casulizing and other steps. It is used to treat chronic hepatitis B and has high safety, high curative effect and low cost.
Description
The present invention relates to the medicinal preparation of the material preparation that derives from plant and the preparation method of this medicinal preparation.
Capsular prescription and each pharmaceutical quantities ratio of treatment chronic hepatitis B are: Radix Rehmanniae Preparata 3-7%, Radix Polygoni Multiflori Preparata 2-5%, Fructus Lycii 3-7%, Fructus Toosendan 2-5%, Radix Curcumae 2-5%, Radix Salviae Miltiorrhizae 8-13%, Radix Angelicae Sinensis 2-5%, Radix Notoginseng 1-2%, Herba Sedi 8-13%, Herba Abri 8-13%, Radix Codonopsis 8-13%, Radix Glehniae 8-13%, Radix Ophiopogonis 2-5%, Radix Rehmanniae 3-7%, Fructus Hordei Germinatus 8-13%, Radix Bupleuri 2-5%.Its method for making is for earlier will be through concocting seven flavors such as Radix Rehmanniae after qualified, Radix Polygoni Multiflori Preparata, Radix Glehniae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Toosendan, Radix Bupleuri in the prescription ratio through the certain density alcohol reflux of several times for several times, filter, filtrate merging leaves standstill, after getting the supernatant decompression recycling ethanol, be concentrated into the extractum of suitable relative density, standby.Seven flavors such as Radix Rehmanniae Preparata, Fructus Lycii, Radix Ophiopogonis, Radix Codonopsis, Herba Sedi, Herba Abri, Fructus Hordei Germinatus filter respectively with the several times water extraction for several times, and merging filtrate leaves standstill, and gets the extractum that supernatant is evaporated to suitable relative density, and is standby.Radix Notoginseng, Radix Curcumae two flavor medicines mix to be pulverized, and sieves, and fine powder and above-mentioned extractum combination drying add appropriate amount of auxiliary materials to doing after pulverizing again, sieve, and incapsulate promptly.
The objective of the invention is provides a kind of safe, good effect, cheap special-purpose medicinal preparation and preparation method thereof at chronic hepatitis B patient.
The capsule of treatment chronic hepatitis B of the present invention is that dizzy order is puckery at the hepatitis B patient hepatic and renal YIN deficiency, wet stasis of blood resistance network, soreness of the waist and knees, side of body rib dull pain, indigestion and loss of appetite, spiritlessness and weakness, dysphoria with feverish sensation in the chest palms and soles, characteristics such as it is not well to defecate.
The capsule of treatment chronic hepatitis B of the present invention is made up of following composition: Radix Rehmanniae Preparata 48-112g, Radix Polygoni Multiflori Preparata 32-80g, Fructus Lycii 48-112g, Fructus Toosendan 32-80g, Radix Curcumae 32-80g, Radix Salviae Miltiorrhizae 128-208g, Radix Angelicae Sinensis 32-80g, Radix Notoginseng 12-21g, Herba Sedi 128-208g, Herba Abri 128-208g, Radix Codonopsis 128-208g, Radix Glehniae 128-208g, Radix Ophiopogonis 32-80g, Radix Rehmanniae 48-112g, Fructus Hordei Germinatus 128-208g, Radix Bupleuri 32-80g.
Radix Rehmanniae Preparata this product is the process of preparing Chinese medicine processed goods of the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosaLibosch..
This product should meet pertinent regulations under the 94th page of Radix Rehmanniae item of 2 years versions of Chinese Pharmacopoeia.
Radix Polygoni Multiflori Preparata this product is the process of preparing Chinese medicine processed goods of the dried root of polygonum multiflorum thunb Polygonum multiflorumThunb..
This product should meet pertinent regulations under the 140th page of Radix Polygoni Multiflori Preparata item of 2 years versions of Chinese Pharmacopoeia.
Fructus Lycii this product is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..
This product should meet pertinent regulations under the 202nd page of Fructus Lycii subitem of 2 years versions of Chinese Pharmacopoeia.
Fructus Toosendan this product is the dry mature fruit of Meliaceae plant Fructus Toosendan Melia toosendan Sieb.etZucc..
This product should meet the 31st page of Fructus Toosendan pertinent regulations of 2 years versions of Chinese Pharmacopoeia.
Radix Curcumae this product is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.chen et C.Ling., Rhizoma Curcumae Longae Curcuma louga L., Guangxi zedoary CurcumaKwangsiensis S.G.Lee et C.F.Liang or Rhizoma Curcumae Curcumaphaeocaulis Val..
This product should meet pertinent regulations under the 166th page of Radix Curcumae item of 2 years versions of Chinese Pharmacopoeia.
Radix Salviae Miltiorrhizae this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..
This product should meet pertinent regulations under the 57th page of Radix Salviae Miltiorrhizae item of 2 years versions of Chinese Pharmacopoeia.
Radix Angelicae Sinensis this product is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.
This product should meet pertinent regulations under the 101st page of Radix Angelicae Sinensis item of 2 years versions of Chinese Pharmacopoeia.
Radix Notoginseng this product is the dry root of panax araliaceae plant Panax notoginseng (Burk) F.H.Chen.
This product should meet pertinent regulations under the 10th page of Radix Notoginseng item of 2 years versions of Chinese Pharmacopoeia.
Herba Sedi this product is the fresh or dry herb of Crassulaceae value thing Herba Sedi Sedum sarmentosum Bunge.
This product should meet pertinent regulations under the 172nd page of Herba Sedi item of 2 years versions of Chinese Pharmacopoeia.
Herba Abri this product is the dry Herb of leguminous plant abrus cantoniensis Hance Abrus cantoniensisHance.
This product should meet pertinent regulations under the 151st page of Herba Abri item of 2 years versions of Chinese Pharmacopoeia.
Radix Codonopsis this product is the dry root of Radix Platycodonis plant Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., plain flower Radix Codonopsis Codonopsis pilosula Nannf.Var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..
This product should meet pertinent regulations under the 233rd page of Radix Codonopsis item of 2 years versions of Chinese Pharmacopoeia.
Radix Glehniae this product is the dry root of samphire glehnia littoralis Glehnia Littoralis Fr.Schmidt ex Miq..
This product should meet pertinent regulations under the 75th page of Radix Glehniae item of 2 years versions of Chinese Pharmacopoeia.
Radix Rehmanniae this product is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosaLibosch..
This product should meet pertinent regulations under the 94th page of Radix Rehmanniae item of 2 years versions of Chinese Pharmacopoeia.
Radix Ophiopogonis, this product was the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..
This product should meet pertinent regulations under 2 years versions of Chinese Pharmacopoeia item one one the 122nd page Radix Ophiopogonis.
Fructus Hordei Germinatus this product is that the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. gets through the drying of germinateing.
This product should meet pertinent regulations under the 122nd page of Fructus Hordei Germinatus item of 2 years versions of Chinese Pharmacopoeia.
Radix Bupleuri this product is the dry root of umbelliferae bupleurum Bupleurum Chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorzonerifolium willd..
This product should meet pertinent regulations under the 232nd page of Radix Bupleuri item of 2 years versions of Chinese Pharmacopoeia.
In this prescription, the sweet tepor of Radix Rehmanniae Preparata nature and flavor can nourishing YIN and supplementing blood, beneficial essence fills out marrow, and the puckery temperature of Radix Polygoni Multiflori Preparata bitter but sweet flavor can invigorating the liver and kidney, benefiting essence-blood, more than two flavor nourishing liver and kidney, nourishing YIN and benefiting blood with treating the liver this, be we's monarch drug.Radix Glehniae, Radix Ophiopogonis, Radix Angelicae Sinensis, Fructus Lycii, tonifying YIN and easing the affected liver, Radix Codonopsis replenishing QI to invigorate the spleen, above Six-element are that we's ministerial drug and monarch drug promotes the production of body fluid with nourishing YIN and benefiting blood.The Radix Bupleuri suffering is slightly cold, energy soothing liver-QI for relieving depression, Fructus Toosendan bitter cold, can soothing liver-QI circulation of qi promoting, Radix Curcumae suffering and bitter cold can regulating qi to disperse stagnation, promoting the function of the gallbladder to alleviate jaundice, the Radix Salviae Miltiorrhizae hardship is slightly cold, the energy blood circulation promoting and blood stasis dispelling, the sweet little bitter temperature of Radix Notoginseng can be stopped blooding the sweet light cold of Herba Sedi by dissipating blood stasis, clearing away heat-damp and promoting diuresis, detoxifcation, the sweet temperature of Herba Abri is bitter cool, energy heat-clearing and toxic substances removing, Shugan Zhitong, more than seven flavors altogether the long memorial liver and qi, nourish blood and the effect of battalion, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, be we's adjuvant drug.The Fructus Hordei Germinatus spleen benefiting and stimulating the appetite, promote qi circulation digestion promoting is making of we.All medicines share, energy liver and kidney tonifying, vital energy regualting and blood circulation-promoting, invigorating the spleen and benefiting QI, clearing away heat-damp and promoting diuresis.
The capsular preparation method of treatment chronic hepatitis B of the present invention is made up of following steps:
(1) all medical materials should be qualified through concocting.
(2) get Radix Rehmanniae, Radix Polygoni Multiflori Preparata, Radix Glehniae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Toosendan, Radix Bupleuri etc., with alcohol reflux repeatedly, merge ethanol extract, reclaim ethanol, being concentrated into relative density is the extractum of 1.08-1.28 (50 ℃), standby.
(3) get seven flavors such as Radix Rehmanniae Preparata, Fructus Lycii, Radix Ophiopogonis, Radix Codonopsis, Herba Sedi, Herba Abri, Fructus Hordei Germinatus, decoct with water repeatedly, decoction liquor is filtered, and merges, and being concentrated into relative density is the extractum of 1.08-1.28 (50 ℃), standby.
(4) get Radix Notoginseng, Radix Curcumae two flavor medicines, mix and pulverize, cross sieve No. six.
(5) get the extractum of step (two), (three) gained and the fine powder and the appropriate amount of starch combination drying of step (four) gained and extremely do, pulverize and insert in the capsulae vacuus, packing.
In preparation technology of the present invention, used concentration of alcohol is 75%, and the dosage form that is become is pharmaceutically acceptable dosage form, as capsule, tablet, granule, syrup, oral solutions etc.
The capsule of treatment chronic hepatitis B of the present invention, prove through acute toxicity test, long term toxicity test and clinical trial, have no side effect, and liver and kidney tonifying is arranged, vital energy regualting and blood circulation-promoting, replenishing QI to invigorate the spleen, the effect of clearing away heat-damp and promoting diuresis, can stop duplicating of hepatitis B virus effectively, be applicable to the hepatic and renal YIN deficiency of chronic hepatitis, chronic active hepatitis B, wet stasis of blood resistance network card, show as mainly that dizzy order is puckery, soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, side of body rib dull pain or twinge, indigestion and loss of appetite abdominal distention, fatigue and weakness, it is not well to defecate, the bitter taste yellowish urine, red tongue with a little fluid, stringy and thready pulse or symptom such as count accurately.
Be embodiment of the present invention below:
Get Radix Rehmanniae 83.33 grams, Radix Polygoni Multiflori Preparata 55.56 grams, Radix Glehniae 166.67 grams, Radix Angelicae Sinensis 55.56 grams, Radix Salviae Miltiorrhizae 166.67 grams, Fructus Toosendan 55.56 grams, Radix Bupleuri 55.56 gram, more than seven flavors respectively with six times, four times amount 75% alcohol reflux secondaries, each 2 hours, filter to merge alcohol extract, leave standstill and get supernatant and be evaporated to the extractum that relative density is 1.18-1.20 (50 ℃); Get Radix Rehmanniae Preparata 81.33 grams, Fructus Lycii 83.33 restrains, restrain Radix Ophiopogonis 55.56, Radix Codonopsis 166.67 grams, Herba Sedi 166.67 grams, Herba Abri 166.67 grams, Fructus Hordei Germinatus 166.67 grams, this seven flavor decocts with water twice, each 1.5 hours, decocting liquid filtered and merges, and being concentrated into relative density is the extractum of 1.18-1.20 (50 ℃), get Radix Notoginseng 16.67 grams, Radix Curcumae 55.56 grams, two flavor medicines mix to be pulverized, and crosses sieve No. six, get fine powder and add medicinal starch 60 grams, with above-mentioned extractum spraying combination drying, pulverize, cross sieve No. six, incapsulate, make 1000 altogether promptly.
Claims (4)
1, the capsule and the preparation method of treatment chronic hepatitis B is characterized in that being made up of following composition: Radix Rehmanniae Preparata 48-112g, Radix Polygoni Multiflori Preparata 32-80g, Fructus Lycii 48-112g, Fructus Toosendan 32-80g, Radix Curcumae 32-80g, Radix Salviae Miltiorrhizae 128-208g, Radix Angelicae Sinensis 32-80g, Radix Notoginseng 12-21g, Herba Sedi 128-208g, Herba Abri 128-208g, Radix Codonopsis 128-208g, Radix Glehniae 128-208g, Radix Ophiopogonis 32-80g, Radix Rehmanniae 48-112g, Fructus Hordei Germinatus 128-208g, Radix Bupleuri 32-80g.
2, according to the capsule and the preparation method of the described treatment chronic hepatitis B of claim 1, it is characterized in that forming by following steps:
(1) all medical materials should be qualified through concocting.
(2) get Radix Rehmanniae, Radix Polygoni Multiflori Preparata, Radix Glehniae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Toosendan, Radix Bupleuri etc., with alcohol reflux repeatedly, merge ethanol extract, reclaim ethanol, being condensed into relative density is the extractum of 1.08-1.28 (50 ℃), standby.
(3) get seven flavors such as Radix Rehmanniae Preparata, Fructus Lycii, Radix Ophiopogonis, Radix Codonopsis, Herba Sedi, Herba Abri, Fructus Hordei Germinatus, decoct with water repeatedly, decoction liquor is filtered, and merges, and being concentrated into relative density is the extractum of 1.08-1.28 (50 ℃), standby.
(4) get Radix Notoginseng, Radix Curcumae two flavor medicines, mix and pulverize, cross sieve No. six.
(5) get the extractum of step (two), (three) gained and the fine powder of step (four) gained, an amount of combination drying to doing, pulverize, insert in the capsulae vacuus packing.
3,, it is characterized in that used concentration of ethanol scope is 40-95% (V/V) according to the capsule and the preparation method of claim 1 and the described treatment chronic hepatitis B of claim 2.
4, according to the capsule and the preparation method of claim 1 and the described treatment chronic hepatitis B of claim 2, the pharmaceutically acceptable dosage form that is become is oral formulations such as capsule, tablet, granule, syrup, oral solutions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01133609 CN1416848A (en) | 2001-10-30 | 2001-10-30 | Capsule for treating chronic hepatitis B and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01133609 CN1416848A (en) | 2001-10-30 | 2001-10-30 | Capsule for treating chronic hepatitis B and its prepn |
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| CN1416848A true CN1416848A (en) | 2003-05-14 |
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| CN 01133609 Pending CN1416848A (en) | 2001-10-30 | 2001-10-30 | Capsule for treating chronic hepatitis B and its prepn |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843707B (en) * | 2009-10-28 | 2011-09-28 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating chronic hepatitis |
| CN102657827A (en) * | 2012-06-01 | 2012-09-12 | 金海英 | Traditional Chinese medicine used for treating liver and gall diseases and preparation method thereof |
-
2001
- 2001-10-30 CN CN 01133609 patent/CN1416848A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843707B (en) * | 2009-10-28 | 2011-09-28 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating chronic hepatitis |
| CN102657827A (en) * | 2012-06-01 | 2012-09-12 | 金海英 | Traditional Chinese medicine used for treating liver and gall diseases and preparation method thereof |
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| PB01 | Publication | ||
| ASS | Succession or assignment of patent right |
Owner name: WUHAN JIANMIN GROUP SUIZHOU PHARMACEUTICAL CO., L Free format text: FORMER OWNER: SUIZHOU PHARMACEUTICAL CO., LTD., WUHAN JIANMIN GROUP Effective date: 20040604 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20040604 Address after: 441300 Suizhou Economic Development Zone, Hubei Applicant after: Suizhou Pharmaceutical Co., Ltd., Jianmin Group, Wuhan City Address before: 441300 No. 269, Suizhou, Hubei, Jiefang Road Applicant before: Suizhou Pharmaceutical Co., Ltd., Wuhan Jianmin Group |
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| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |