CN1398647A - Permanent magnetic suppository and its usage - Google Patents
Permanent magnetic suppository and its usage Download PDFInfo
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- CN1398647A CN1398647A CN 02102913 CN02102913A CN1398647A CN 1398647 A CN1398647 A CN 1398647A CN 02102913 CN02102913 CN 02102913 CN 02102913 A CN02102913 A CN 02102913A CN 1398647 A CN1398647 A CN 1398647A
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- suppository
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Abstract
The permanent magnetic suppository consists of un-magnetized permanent magnetic alloy particle and matrix liquid. When being used, the permanent magnetic suppository is injected selectively into tumor bloods supplying vessel via intervention technological process and its alloy particle is then magnetized via in vitro strong static magnetic field. Some alternate magnetic field is acted to the tumor tissue to produce induced eddy current and great amount of heat energy. The present invention is easy to operate and has high curative effect.
Description
The invention belongs to the tumor thermotherapy technical field, be specifically related to a kind of permanent magnetic suppository and using method.
Present therapies such as most single employing frequency, ultrasound wave, microwave in the thermotherapy technical field of tumor, these therapies all have some identical defectives, first: normal structure and tumor tissues are all had the heat damage effect, can not effectively tumor tissues and normal structure well be made a distinction, and it is limited to the destruction at tumor tissues edge, mainly be that the borderline tumor part compares with normal structure, the situation of being heated is close, does not often reach the treatment temperature.So the recurrence after the thermotherapy of tumor all occurs in the edge of tumor tissues.Second: blood vessel structure in the tumor tissues and the microcirculation tumor vessel net system that compares with normal structure is congenital bad and the tumor vessel neural sensor is unsound, can take away more heat so that tumor tissues can not can be expanded as the blood vessel in the normal structure to greatest extent in heating, but tumor vessel can be taken away the part heat still and makes the heating of tumor tissues is failed to reach fully optimal boundary.The tumor intervention therapeutic technology provides comparatively ideal method at the blood supplier face to the blocking-up tumor now, and in the topical therapeutic of tumor, obtained gratifying achievements, but it also has an apparent in view weak point: liquefaction and necrosis takes place in the center of tumor tissues, and often there is the existence of remaining focus at the edge of tumor tissues, and it is more common particularly not having this situation of tumor of peplos.
Present nano-magnetic fluid will be expected to be used in the intervention magnetic thermotherapy of tumor, but in the magnetostatic captivation that will overcome between the microgranule among the nano-magnetic fluid each other, and what need in the treatment is the permanent magnet material of high remanent magnetism, high magnetic energy product, high-coercive force, and this has just formed contradiction.So the permanent-magnet alloy microgranule in the nano-magnetic fluid does not often reach our needed intensity.Because microgranule can be subjected to the influence of mutual magnetostatic field in the magnetic liquid, so that microgranule will be done in the magnetic liquid is very little, this is just higher to the processing request of microgranule.To such an extent as to raising production cost.
The objective of the invention is to provide a kind of and can be effectively combine, and help thermotherapeutic suppository and the using method thereof that big institute of traditional Chinese medicine uses with regard to the interventional therapeutic technique of the thermotherapy of tumor and tumor at the deficiencies in the prior art.This suppository not only has tip suppository commonly used thromboembolism effect to the tumor tissues peripheral vessel, and it can also be converted into eddy current with the energy major part that adds alternating magnetic field, produces a large amount of heat energy.Fully use the back magnetization technology simultaneously: after interventional embolization, again the permanent-magnet alloy microgranule is carried out hard magnetization, make that operation is simpler, use more convenient better efficacy.
Purpose of the present invention can realize in the following manner that alloy particle and base fluid two parts that thermotherapeutic suppository is made by permanent magnet material are formed.Using method is: the supply vessels that the thermotherapy interposition suppository is injected tumor with the interventional technique super-selective, at the external strong static magnetic field that gives earlier, with the alloy particle in suppository magnetization and then pass to alternating magnetic field, and make tumor tissues place among the alternating magnetic field to greatest extent.
Alloy particle in the aforesaid thermotherapeutic suppository is to handle without magnetization and to have a microgranule that the permanent magnet material of high remanent magnetism, high maximum magnetic energy product, high-coercive force processes.This alloy particle is good with the rare-earth cobalt alloy material.
The diameter of aforesaid alloy particle can be that micron order also can be that nanoscale or existing micron order also have nano level microgranule.If micron order then it diameter be good with 5～15 microns because can make like this alloy particle to greatest extent thromboembolism in the tumor capillary network.If nanoscale then it must be enough little so that in base fluid, present chaotic Brownian movement, this warm-up movement is enough to offset the settlement action of gravity and overcomes the particle aggregation that Van der Waals for causes, and does not produce precipitation and cohesion.The maximum gauge of nano_scale particle is decided by employed permanent magnet material, and its surface should be coated with surfactant simultaneously, and the effect of surfactant has: prevent the oxidation of alloy particle 1.; 2. the particle aggregation that overcomes Van der Waals for and caused; 3. change the character on alloy particle surface, make that microgranule and base fluid are muddy to be integral.The requirement total to surfactant be, an end of activating agent can be adsorbed in microparticle surfaces, forms very strong chemical bond, the other end can with the base fluid solvation.Base fluid in the aforesaid thermotherapeutic suppository is mainly by the decision of the size of alloy particle, if contain in the microgranule or have only high concentration micron order microgranule then base fluid can be the iodized oil class gets involved contrast agent.If the nano_scale particle of high concentration is arranged in the alloy particle then base fluid must be the base fluid that helps making nano-scale magnetic liquid.
Base fluid in the aforesaid thermotherapeutic suppository can be the base fluid that contains chemicals, effectively thermotherapy and chemotherapy technology is combined.It also can contain nanometer guide medicine (chemical medicine, physical property medicine etc.)
The invention has the advantages that:
1, the present invention fully arrives tumor by local thermotherapy and intervention embolization effective connection together.
2, because the alloy particle in the suppository does not possess magnetic (handling without magnetization) before interventional embolization, because there do not had magnetostatic captivation just to make that nano level alloy particle can be done between the microgranule to be bigger, it is easier to produce.Thereby the situation appearance of the cohesion reduction effect of embolization of microgranule can not take place to take place owing to the effect of magnetostatic field between the microgranule for the micron order alloy particle yet.
3, because people's physical ability is born very strong magnetostatic field, so very safe ready ground fully magnetizes the permanent-magnet alloy microgranule of thromboembolism in tumor tissues.
4, since the permanent-magnet alloy microgranule compare with tissue and have very strong eddy-current loss, obviously produce more thermal energy so contain the tumor tissues of a large amount of permanent-magnet alloy microgranules than normal structure, the heat energy that produces can't be taken away because of the thromboembolism of blood vessel, heat energy is further accumulated, to make the tumor tissues temperature of comparing with normal structure obviously raise, and can reach the needed temperature of tumor coagulation necrosis easily.Obviously reduced influence during such benefit to normal structure.
5, because the permanent-magnet alloy microgranule can not forever stay in tumor tissues for tissue degradation, rest on a small quantity in the contiguous tissue, usually can be as required repeatedly to the tumor tissues heating, up to the complete coagulation necrosis of tumor tissues with regard to only needing once to get involved.
6, since the most of thromboembolism of permanent-magnet alloy microgranule in the capillary network of the tumor edge of tumor tissues particularly, such consequence is that the lip temperature of tumor tissues is obviously higher, destroy and obviously increase the weight of, the deficiency that can remedy tumor thermotherapy technology and interventional technique is promptly: the center to tumor tissues is destroyed obviously, but can not destroy the borderline tumor tissue up hill and dale effectively.And benefit of the present invention is exactly to destroy the edge of tumor tissues more up hill and dale.
7, owing to can just can improve the temperature of tumor tissues heating, owing to the conduction of temperature and then can enlarge destructive zone by suitable enhancing alternating magnetic field intensity.And can be as required and this suppository is injected the supply vessels of tumor normal surrounding tissue, enlarge the destructive scope that needs, just simple as selection excision scope in the operation.Such benefit is to make the present invention to the wettability tumor curative effect preferably be arranged, and can change intervention embolization to the wettability tumor situation of unsatisfactory curative effect often.
8, the effect owing to magnetostatic field between the permanent-magnet alloy microgranule makes the permanent-magnet alloy microgranule in the suppository condense, better thromboembolism is in the blood capillary of tumor tissues, make base fluid etc. liquid suppository be more difficult and in tumor vessel, broken up that thromboembolism improves curative effect in the tumor blood capillary more enduringly by blood flow.
Be further elaborated below in conjunction with the suppository among a pair of the present invention of embodiment:
With diameter is that 5～15 microns rare earth cobalt alloy (unmagnetized) is dispersed in and makes the colloid interposition suppository in the iodized oil.
Now the suppository among the two couples of the present invention is further elaborated in conjunction with the embodiments:
The even colloid solution that uses existing nanotechnology that nano-scale rare earth Co permanent magnetic alloy (unmagnetized) microparticulate is formed in base fluid.
Now the suppository among the three couples of the present invention is further elaborated in conjunction with the embodiments: the even colloid solution that uses existing nanotechnology that nano-scale rare earth Co permanent magnetic alloy (unmagnetized) microparticulate is formed in base fluid.Again with micron-sized permanent-magnet alloy (unmagnetized) microparticulate in colloid solution.
Below be that making of thermotherapeutic suppository is used as further narration:
At first thermotherapeutic suppository is injected the supply vessels of tumor, utilize CT etc. to observe suppository full situation in tumor tissues with the interventional technique super-selective.Pass to strong static magnetic field then with the permanent-magnet alloy microgranule in the magnetization suppository in external or corresponding human body lacuna, magnetized intensity will be magnetized the easy magnetization district in the permanent-magnet alloy at least fully.Pass to alternating magnetic field again, and make tumor tissues place among the alternating magnetic field to greatest extent.The frequency of alternating magnetic field is good with 0.05～2MHz.
Claims (8)
1, a kind of permanent magnetic suppository, it is made up of permanent-magnet alloy microgranule and base fluid, it is characterized in that: the permanent-magnet alloy microgranule of handling without magnetization is dispersed in the base fluid.
2, permanent magnetic suppository as claimed in claim 1 is characterized in that: alloy particle is to handle and have a microgranule that the permanent magnet material of high remanent magnetism, high maximum magnetic energy product, high-coercive force processes without magnetization.This alloy particle is good with the rare-earth cobalt alloy material.
3, permanent magnetic suppository as claimed in claim 1 is characterized in that: the diameter of alloy particle can be that micron order also can be that nanoscale or existing micron order also have nano level microgranule.If micron order then it diameter be good with 5～15 microns.
4, permanent magnetic suppository as claimed in claim 1 is characterized in that: treat base fluid in the suppository mainly by the size decision of alloy particle, if contain in the microgranule or have only high concentration micron order microgranule then base fluid can be the iodized oil class gets involved contrast agent.If the nano_scale particle of high concentration is arranged in the alloy particle then base fluid must be the base fluid that helps making nano-scale magnetic liquid.
5, permanent magnetic suppository as claimed in claim 1 is characterized in that: base fluid can be to contain the base fluid of chemicals or contain the guide medicine to comprise chemical, physical property guide medicine.
6, its using method of permanent magnetic suppository as claimed in claim 1 is: the supply vessels that permanent magnetic suppository is injected tumor with the interventional technique super-selective, in external or corresponding human body lacuna, pass to strong static magnetic field then with the permanent-magnet alloy microgranule in the magnetization suppository, pass to alternating magnetic field again, and make tumor tissues place among the alternating magnetic field to greatest extent.
7, using method as claimed in claim 6 is characterized in that: magnetized intensity will be magnetized the easy magnetization district in the permanent-magnet alloy at least fully.
8, using method as claimed in claim 6 is characterized in that: the frequency of alternating magnetic field is good with 0.05～2MHz.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02102913 CN1398647A (en) | 2002-01-27 | 2002-01-27 | Permanent magnetic suppository and its usage |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02102913 CN1398647A (en) | 2002-01-27 | 2002-01-27 | Permanent magnetic suppository and its usage |
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| CN1398647A true CN1398647A (en) | 2003-02-26 |
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| CN 02102913 Pending CN1398647A (en) | 2002-01-27 | 2002-01-27 | Permanent magnetic suppository and its usage |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888313A (en) * | 2018-06-29 | 2018-11-27 | 华中科技大学 | A kind of manipulation magnetic Nano material promotes the device of thrombolysis efficiency in vein |
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2002
- 2002-01-27 CN CN 02102913 patent/CN1398647A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888313A (en) * | 2018-06-29 | 2018-11-27 | 华中科技大学 | A kind of manipulation magnetic Nano material promotes the device of thrombolysis efficiency in vein |
| CN108888313B (en) * | 2018-06-29 | 2021-01-19 | 华中科技大学 | Device for controlling magnetic nano material to improve thrombolysis efficiency in vein |
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