CN1390484A

CN1390484A - Preparing process and product of EDTA iron chelate as nutritive intensifier of food

Info

Publication number: CN1390484A
Application number: CN01118713A
Authority: CN
Inventors: 李卫平
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-06-07
Filing date: 2001-06-07
Publication date: 2003-01-15

Abstract

An EDTA-iron chelate as nutritive intensifier is prepared through the reaction between EDTA tetrasodium and FeCl3 or between refined iron powder, hydrochloric acid and EDTA, regulating pH value with NaOH, and crystallizing. Its advantages are low cost, high stability and solubility in water, high bioactivity and easy absorption. It can promote the absorption of Fe and Zn.

Description

Preparation method of EDTA iron chelate as nutritive intensifier of food and products thereof

The present invention relates to a kind of foodstuff additive, particularly relate to preparation method of EDTA iron chelate as nutritive intensifier of food and products thereof.

Iron is human body requirement maximum, and the most a kind of trace element of easy shortage.Hypoferric anemia has very serious harm to the health of human body, easily causes all kinds of herd immunities and descends.Dietotherapy is in recent years mended iron and has been caused people's extensive concern.The iron of ingesting is strengthened and oral chalybeate is considered to the measure of the long-term prevention hypoferric anemia of " inexpensive " usually.Investigation shows that the dietary iron feed rate of China urban and rural residents is not low, and the major cause of hypoferric anemia is irony malabsorption (except the other diseases factor).The chalybeate kind of domestic present production is all relative with formulation less, and principal item is ferrous sulfate, Ferrous Fumarate, iron lactate, Ferrous Gluconate, ferric ammonium citrate etc.Common oral chalybeate is owing to the stimulation of iron ion to mucous membrane, and gastrointestinal side effect is bigger, makes people be difficult to accept.The oral chalybeate of ideal should meet following several standards:

A easily absorbs;

B does not have iron taste and gum dyes black phenomenon;

C does not have enteron aisle to be stimulated;

D does not have iron ion and exists, and has special duodenum to absorb;

E does not have side reactions such as nausea and vomiting abdominal pain diarrhea, and security is good.

Advantages such as passing through and discover that the EDTA iron chelate meets above several standards, have no iron taste, easily absorb, have special duodenum to absorb, is 2～3 times of ferrous sulfate specific absorption, and security is good.We just begin to carry out the study on the synthesis of EDTA iron chelate in November, 1997, highly purified food grade FeNaEDTA and two EDTA iron chelate have been produced, and (a kind of iron-supplementing instant effervescent particles and production method thereof, application number is: 00107559.4) to have declared wherein the patent of invention of one of purposes on May 19th, 2000.

Purpose of the present invention just provides a kind of simple and convenient process for preparing and products thereof of above-mentioned EDTA iron chelate of biologically active.

EDTA iron chelate of the present invention is light yellow or shallow brown crystalline powder, and its molecular formula is: C ₁₀H ₁₂FeN ₂NaO ₈3H ₂O or C ₂₀H ₂₄Fe ₂N ₄O ₁₆XH ₂O.

One of EDTA iron chelate of the present invention FeNaEDTA (ferric iron) preparation method is: take by weighing a certain amount of EDTA four sodium and add in the suitable quantity of water, heating makes it to dissolve fully, mol ratio according to required configuration, take by weighing a certain amount of iron trichloride again and slowly join in EDTA four sodium solutions, be heated to 60～100 ℃ of stirring reactions 1～3 hour, reaction is to clarification, filtered while hot, add an amount of crystal seed when filtrate is cooled to 20～50 ℃ again, the static precipitation that makes is separated out, and refining drying obtains finished product.

Among the preparation method of FeNaEDTA of the present invention, the optimum molar coordination ratio of the complex reaction of EDTA four sodium and iron trichloride is 1～1.15: 1, and PH is 4～7, and temperature of reaction is 60～100 ℃.

The preparation method of a pair of EDTA iron chelate (ferrous iron) of EDTA iron chelate of the present invention is: take by weighing a certain amount of refining iron powder (reduced iron or electrolytic iron) and add dilute hydrochloric acid to no longer including the gas generation, slowly add an amount of EDTA again, and to regulate pH value with NaOH solution be 4～7, be heated to 35～60 ℃ of stirring reactions 1～3 hour, make it to dissolve fully, reaction is to clarification, filtered while hot, when being cooled to 20～50 ℃, filtrate adds an amount of crystal seed again, the static precipitation that makes is separated out, and refining drying obtains finished product.

It is reasonable, simple and easy to do that above preparation method of the present invention compared with prior art has technology, and productive rate is up to 90%, and the purity height, and the no three wastes produce.

The present invention is described further below in conjunction with embodiment, is limitation of the present invention but should not be construed as.

Embodiment 1:

Taking by weighing 45.2gEDTA four sodium adds in the 80ml water, heating makes it to dissolve fully, take by weighing again in the 27g iron trichloride adding 40ml water and slowly join in EDTA four sodium solutions after the dissolving, be heated to 65 ℃ of stirring reactions 1.5 hours, reaction is to clarification, and filtered while hot adds 5g FeNaEDTA powder again when filtrate is cooled to 45 ℃, the static precipitation that makes is separated out, and refining drying obtains the 44.7g finished product.

Embodiment 2:

Take by weighing the 30g reduced iron powder and add 15% dilute hydrochloric acid (about 250ml) and produce, slowly add 75gEDTA again, and be 4.5 with NaOH solution adjusting pH value to no longer including gas, be heated to 50 ℃ of stirring reactions 1 hour, reaction is to clarification, and filtered while hot adds 10gFe again when filtrate is cooled to 45 ℃ ₂The EDTA powder, the static precipitation that makes is separated out, and refining drying obtains the 106g finished product.

Claims

1. foodstuff additive is characterized in that EDTA iron chelate as nutritive intensifier of food.

2. an EDTA iron chelate as claimed in claim 1 is characterized in that referring to EDTA ferric chelate (FeNaEDTA) and two EDTA ferrous iron inner complex (Fe ₂EDTA).

3. FeNaEDTA preparation method as claimed in claim 2, the optimum molar coordination ratio that it is characterized in that the complex reaction of EDTA four sodium and iron trichloride is 1～1.15: 1, PH is 4～7, temperature of reaction is 60～100 ℃, reaction times is 1～3 hour, adds an amount of crystal seed when being cooled to 20～50 ℃ again.

4. Fe as claimed in claim 2 ₂The EDTA preparation method is characterized in that refining iron powder is reduced iron or electrolytic iron, and temperature of reaction is 35～60 ℃.