The present invention compares with prior art:
1, the silver addressed of (1) (2) of prior art does not all belong to nanometer-level silver plasmid.
2, the antibiotic material addressed of (3) (4) (5) of prior art is a copper ion.
3, (6) of prior art antibiotic material of being addressed is that the elemental silver of ultramicron is not addressed the more superior Ag of anti-microbial property
2O.
One of purpose of the present invention provides a kind of compound (Ag+Ag
2O) anti-coagulation nano silver antibacterial non-woven product.
Two of purpose of the present invention provides a kind of technology of gathering between the active extremely strong silver ultramicron of preventing.
Three of purpose of the present invention provides a kind of compound (Ag+Ag
2O) industrialized producing technology of anti-coagulation nano silver antibacterial non-woven.
Four of purpose of the present invention provides a kind of compound (Ag+Ag
2O) successfully use the atomizing new technology in the industrialized producing technology of anti-coagulation nano silver antibacterial non-woven.
These and other objects of the present invention will and be described and further set forth by following detailed description.
A kind of compound (Ag+Ag
2O) anti-coagulation nano silver antibacterial non-woven adopts to prevent the step gathered between the active extremely strong silver ultramicron in manufacturing process.
Described compound (Ag+Ag
2O) anti-coagulation nano silver antibacterial non-woven, it is firmly and equably to be attached with ultra micron silver between the fiber element method of non-woven fabric material He on the fiber, and its particle diameter is 1~100 nanometer, and the top layer of this ultra micron silver is the silver oxide (Ag of 2~8 nanometers
2O), core is elemental silver (Ag).
Describedly firmly and equably be attached with ultra micron silver between the fiber element method of non-woven fabric material He on the fiber, silver content is that the basis is 0.1~50 a milligram/gram with non-weaving cloth weight.
Described non-weaving cloth is polyamide fiber, poly-paraphenylene terephthalamide p dimethylamine fiber, polyester fiber, polypropylene fibre, vinylon, polyacrylonitrile fibre, artificial synthetic fiber, can be wherein a kind of separately, also can be to mix to make to be used for making non-weaving cloth.
Described compound (Ag+Ag
2O) anti-coagulation nano silver antibacterial non-woven also can mix with natural fabrics such as cotton, fiber crops, silks to use and make non-weaving cloth.
Described compound (Ag+Ag
2O) industrialized producing technology of anti-coagulation nano silver antibacterial non-woven, comprise the preparation of medicament, non-weaving cloth is carried out the atomization technique spray pharmacy after reactor reaction, steps such as Chemical cleaning, centrifugal dehydration, drying, supercharging homogeneous then, Overall Steps all carries out under ventilation condition.
Described compound (Ag+Ag
2O) industrialized producing technology of anti-coagulation nano silver antibacterial non-woven for the prescription of the soup of spraying usefulness in the production technology is: ingredients A: silver nitrate 0.005~0.3M, ammoniacal liquor 0.002~0.15M, NaOH 0.01~
0.2M adding water to cumulative volume is 50 liters; Ingredients B: Portugal's glucose or ascorbic acid 0.1~5M, nitric acid 0.02~0.2M, ethanol 2~10M,
Adding water to cumulative volume is 5 liters;
During use 10 parts by volume ingredients A are added that 1 parts by volume ingredients B mixes the back and places after 10~40 minutes stand-by.
Described compound (Ag+Ag
2O) industrialized producing technology of anti-coagulation nano silver antibacterial non-woven, medicament to non-weaving cloth, soaks evenly medicament through atomization technique metering ground spray-stain, carries out reactor again and handles.
Described compound (Ag+Ag
2O) purposes of anti-coagulation nano silver antibacterial non-woven, it can be made into medical, health care antimicrobial form functional non-woven cloth.
Further, product of the present invention is that it can be used as the antibiotic property functional material in multiple terminal commodity such as medical treatment, health care, daily-use sanitary product as a kind of functional non-woven cloth with anti-microbial property.It specifically is exactly the skin-material that directly contacts with human body skin.As for various terminal commodity product of the present invention is cut into the selecting for use of material beyond what shape and the product of the present invention, composition etc. and all do not belong to claim scope of the present invention.
Further, product of the present invention can be used as medical (outward) material of treatment burn and scald, material with the skin infection for the treatment of traumatic patient and superficial skin fungus infection and prevention of surgical incision postoperative and treatment infection of incisional wound, and be used for the antibacterial sanitary napkin that the women uses, the diaper that the child uses, prevent and treat the liner that hemorrhoid are used, has broad spectrum antibacterial, long-lasting, kill the drug resistance pathogenic bacteria, hydrophily---meet that the water sterilizing power is stronger, wash resistant, avirulence, nonirritant, no anaphylaxis, excellent properties such as have no drug resistance.The particularly important is field work, explosion injury, penetrating wound, knife wound, burn, the scene control trauma infection contamination under the unsuitable environmental conditions such as the war wound of the seawater pollution surface of a wound, flood, fire, earthquake.The more important thing is that product of the present invention can be used to prevent and treat the intractable bedsore and infect, difficult sexuality such as empyrosis wound surface infection are dyed, and also can be used as normal life health keeping products, have started the industrialization example that nanometer technology is used at the human body anti infection region.
Technology of the present invention can prevent to gather effect between the silver ultramicron of the nanoscale particle diameter that newly-generated surface-activity is very strong, thereby prevent to generate the bigger silver particle of particle diameter in manufacturing process.Through making in laboratory, pilot scale, and go into operation successfully, production run and constant product quality, annual value of production are estimated can reach more than 1,000,000,000 yuan.
Compound (Ag+Ag of the present invention
2O) the anti-coagulation nano silver antibacterial non-woven belongs in the nanomaterial science on artificial synthetic and natural organic substrate and has disperseed the organic of inorganic nano-particle---inorganic nano composite material.Organic carrier is a non-weaving cloth, and inorganic nano is the ultra micron silver of 1~100 nanometer for particle diameter then, can be used as functional material and is applied in the human body anti infection region.About defining of nano material, except particle diameter was 1~100 nanometer, also must possess had this kind nano material to compare with the homogeneous material of macro-size, and the former has the specific performance that is much better than the latter on some important performance.Promptly will have particle diameter 1~100 nanometer and specific performance simultaneously, both are indispensable, otherwise just can not be defined as nano material.The nanometer ultramicron that with particle diameter is 1~100 nanometer is compared with macroscopical particulate of homogeneity, and the former specific surface is very big, and is inversely proportional to particle size.For example: it is 25 nanometers that 1 gram silver is worked as particle diameter, and its specific surface is 30 meters
2/ gram; Adding the atomicity that skin effect promptly is distributed in the particle surface layer simultaneously increases sharply, cause former coordination deficiency, unsaturated bond exposes and increases, the surface energy of atom increases, cause the chemism of these nano level ultramicrons extremely strong, thereby work as the moment that these ultramicrons have just generated, because mutual collision inevitably will take place in warm-up movement, this moment bump two then, even a plurality of ultra microns will gather effect, it is bigger to cause generating particle diameter thus, can be several greater than former particle diameter, tens, the macroparticle of hundred times, even owing to gathering the particle that effect becomes macro-size, its chemism just reduces greatly accordingly, loses the character of nano material the most at last.This shows that the present invention adopts suitable chemistry and physical means to reach to prevent the effect of gathering between newly-generated ultramicron.This anti-centralizing technique is for based on chemical method, and the physics method is that the method success or not of making 1~100 nanometer ultramicron of assisting is vital.In order to prove conclusively the effect of anti-centralizing technique, we carry out the silver sample that adopts and do not adopt this technology, and scanning tunneling microscope detects and photograph, and its effect is tangible.(please referring to Fig. 1, Fig. 2, Fig. 3 and Fig. 4)
Chinese patent publication number CN1241662A, inventor's Jiang Jianhua, " long-acting wide-spectrum antiseptic nanometer silver fabric and manufacture method thereof ", this disclosure of the Invention a kind of long-acting wide-spectrum antiseptic nanometer silver fabric, be attached with ultra micron silver between the fiber of fabric or on the fiber, its top layer is a silver oxide, and core is an argent, and its particle diameter is 1~100 nanometer.
Chinese patent application number 00121287.8, inventor's Jiang Jianhua, Hongjun ZHU, " nanometer silver anti-bacteria cloth and industrialized producing technology thereof ", this disclosure of the Invention a kind of nanometer silver anti-bacteria cloth, between the fiber of cloth and fiber on particle diameter be the silver particle of 1~100 nanometer, the silver amount of the Nano Silver that on nanometer silver anti-bacteria cloth, adheres to be 1~400 microgram/centimetre
2
To publication number CN1241662A, application number 00121287.8, though addressed in nanometer-level silver plasmid elemental silver and silver oxide arranged, but do not address anti-centralizing technique, therefore have the aggregation phenomenon of more silver ultramicron in the manufacturing process of two inventions and produce morely owing to gather the accumulation body that gathers that effect produces big particle diameter, this is for adopting tunnel scanning electronic microscope (SEM) to prevent that to adopting anti-centralizing technique and employing the detection and the photo of centralizing technique manufactured samples are confirmed.Gather accumulation body at Fig. 1, Fig. 2 for not adopting in the anti-centralizing technique sample, Fig. 3 is not for adopting the silver particle that does not gather of anti-centralizing technique sample, its silver number of particles obviously is less than the silver particle among Fig. 4, this is to have consumed a large amount of silver particles owing to having taken place to gather effect, Fig. 4 is the SEM stereoscan photograph that has adopted the sample of anti-centralizing technique, wherein most of silver particle is 25nm, and its silver number of particles is many, and marshalling.
Non-weaving cloth of the present invention is 0.1~50 a milligram/gram with American Pharmacopeia and British Pharmacopoeia institute periodical method, the silver amount of measuring Nano Silver on the non-weaving cloth.
The function of non-weaving cloth of the present invention and detection test thereof are as follows:
Non-weaving cloth of the present invention is measured through electron microscope and photoelectron spectrograph, and as seen the exhausted most particle diameter of its silver particle is the ultramicron of 25 left and right sides nanometers, consists of Ag
2O+Ag, the top layer of particle is Ag
2O, its core is an elemental silver so can be defined as the silver particle of nanoscale particle diameter clearly, as for whether excellent property being arranged, will confirm by following every detection, testing result sees Table 1 and table 2.
The antibiotic mechanism of non-weaving cloth of the present invention is classical antibiotic mechanism:
Therefore the non-weaving cloth of invention mutually is by the most classical antibiotic mechanism, in the enzyme of depending on for existence in the thalline-SH group displacement one-tenth-SAg makes the enzyme loss of activity cause germ death, and have the stronger characteristic of the water sterilizing power of chance, and its product is enzyme 2SAg and H
2There is not the secondary paathogenic factor in O.
By table 1, the non-weaving cloth of the present invention as can be seen of the experimental result shown in the table 2 has following superior specific function.
1, antibiotic broad spectrum activity:
Bacterial classification shown in the table 1, table 2 has comprised grampostive bacteria, and gram-negative bacteria, fungi, brood cell and anaerobic bacteria, antimicrobial spectrum so widely are very rarely seen in existing antibacterials.With regard to table 1 and the related bacterial classification of table 2 remove repetition in respect of 38 bacterial classifications, and most bacterial classification is to separate from the strong clinical patients juice of resistance.
2, long-lasting:
Washing shown in table 1, the table 2 is for 50 times and 20 times that non-weaving cloth is washed the clear water rinsing by rubbing with the hands 50 times and 20 times with soap is manual at every turn.Wash is for 100 times to wash meter by rubbing with the hands 100 times with clear water at every turn, and through the non-weaving cloth of washing, its bacteriostasis property does not have obviously and goes down.
3, non-weaving cloth and 8 antimicrobials are to the comparison of pathogenic bacteria fungistatic effect:
Table 1 is depicted as non-weaving cloth of the present invention (28) and carries out extracorporeal bacteria inhibitor test simultaneously with 28 pathogenic bacteria and erythromycin (7), ampicillin (4), Zinacef (4), cefotaxime (15), Oxacillin (2), gentamicin (6), (14) 8 antimicrobials of Ciprofloxacin.Numeral in the bracket of each nomenclature of drug back is the antibacterial strain number of this medicine energy.The anti-drug resistance pathogenic bacteria that this shows non-weaving cloth can want much superior by these 8 antimicrobials of force rate.This is for the growth of breaking current drug-resistance of bacteria, and the difficult situation that has made antibiotic exploitation be unable to catch up with the bacterial drug resistance growth can be placed hopes on.By on can predict non-weaving cloth of the present invention and may progressively become and substitute antibiotic alternative medicine.
4, hydrophily---chance water sterilizing power is stronger
From table 1, the visible non-weaving cloth of table 2 is through repeatedly washing by rubbing with the hands, and its antibacterial power does not have obviously and goes down, and its dominant mechanism is exactly the Ag on nanometer-level silver plasmid on the non-weaving cloth
2O has sustained release performance, and generally under the condition that has water to exist, even the water yield of the moisture state the when humidity of body surface or application enough makes Ag disengage, as [Ag
+] reach 0.n-5ppm[10
-6] time can reach Ag
+Dynamic equilibrium, and Ag
+Minimum inhibitory concentration be 2 * 10
-11M, can not produce as for the antibiotic mechanism of non-weaving cloth with in antibiotic process the secondary paathogenic factor in front the part of " antibiotic mechanism " illustrate.Also carried out following test in addition, got the non-weaving cloth of 0.5 grammes per square metre, soak with 500 ml waters every day, changes water every day once, and the antibacterial power of this non-weaving cloth does not have obviously and goes down after 45 days.So non-weaving cloth chance water antimicrbial power is stronger.This is very favourable to current burn and scald wet treatment.Its curative effect of clinical verification of the entire PLA of Chinese People's Liberation Army medical test center and The Fourth Military Medical University of P.L.A and attached Xijing hospital thereof is fine, The Fourth Military Medical University of P.L.A is to the in-situ curing research of the war wound of seawater pollution, the curative effect that confirms non-weaving cloth of the present invention is fine, the real genus top standard of the world today is so be specially adapted to do under the unsuitable environmental conditions such as field work and battlefield the infection of control wound.
5, pharmacokinetic
Through new drug Research on Safety Assessment center, national Beijing and medical test center pharmacology section of the entire PLA of the Chinese People's Liberation Army, be subjects with mouse, cavy and white big ear rabbit.With carrying (Ag+Ag
2O) natural fabric powder is that experimental drug is through the skin acute toxicity test, irritation test, sensitivity test and chmice acute toxicity test, the maximum tolerance determination test, and cumulative toxicity test, especially mouse (9) single filling stomach administered dose is 925 milligrams/kilogram of maximal tolerance doses, be equivalent to the people and intend with clinical dosage 4625 times, observed 14 days continuously after the administration, do not find poisoning symptom and death, and growing state is better.Confirm compound (Ag+Ag thus
2O) Nano Silver avirulence, nonirritant, no anaphylaxis has no drug resistance.
6, the external antibacterial contrast of the silver-colored particulate of non-weaving cloth and homogeneity macroscopic view particle diameter.
Directly be 6 millimeters ringlet with the garden, place the micro silver powder of non-weaving cloth of the present invention and macroscopical particle diameter respectively, the former silver content only is the latter's 10
-3~10
-4Yet on external antibacterial agar MH flat board, the former antibacterial ring is 12~20 millimeters, and the latter does not have antibacterial ring.This shows that on bacteriostasis the homogeneity silver particulate and the non-weaving cloth of the present invention of macro-size are incomparable.
In sum, the function of non-weaving cloth of the present invention comprises antibiotic broad spectrum activity, long-lasting, to having the bacteriostasis of drug resistance pathogenic bacteria, hydrophily---chance water sterilizing power is stronger, avirulence (comprising no cumulative toxicity), nonirritant, no anaphylaxis, aspect such as have no drug resistance all have and are much better than current antimicrobial commonly used, also be much better than the homogeneity silver non-weaving cloth of macro-size, thus the silver particle on the non-weaving cloth of the present invention not only met particle diameter be 1~100 nanometer simultaneously but also show special superior anti-microbial property.So the silver particle on the non-weaving cloth of the present invention can be defined as nanometer-level silver plasmid without doubt.
The essence of non-weaving cloth is exactly to have adopted anti-centralizing technique of the present invention and silver (the Ag that produces the ultramicron that evenly and has securely adhered to particle diameter 1~100 nanometer on non-weaving cloth
2O+Ag) particle promptly gets non-weaving cloth of the present invention.
The artificial synthetic fiber that the present invention selects for use are as follows:
Polyamide fiber claims not only nylon or polyamide fibre, poly-paraphenylene terephthalamide p dimethylamine fiber to claim not only B fiber, polyester fiber to claim not only terylene, polypropylene fibre not only to claim polypropylene fibre, vinylon to claim vinylon, polyacrylonitrile fibre not only but also claim acrylic fibers, more than artificial synthetic fiber can be used alone or as a mixture, also add natural fabrics such as cotton, fiber crops, silk, hair in case of necessity.
Industrialized producing technology flow process of the present invention is please referring to shown in the accompanying drawing 5.
In the present invention, processing can be buied or order to non-weaving cloth, assistant agent and additive all from market, dispersant is that general anti-of the industry gathers agent, concrete kind can check in from various conventional hand product, for example, available isopropyl alcohol, neopelex, succinate sodium sulfonate, OP-10, trialkyl phosphates class such as tributyl phosphate, trioctyl phosphate, tri-isoamyl phosphate, the different monooctyl ester of tri o cresyl thiophosphate etc.
In the present invention, employed equipment is the special equipment that specialized designs is made, and anti-centralizing technique and atomization technique have been adopted in the processing of non-weaving cloth, and in the present invention, described anti-centralizing technique is meant that silver-colored particulate prevents centralizing technique.
Below further specify the present invention by specific embodiment, but embodiment only be used for the explanation can not limit the scope of the invention.
If not refer in particular to all parts, measure the unit of weight that is based on gross weight in the present invention, " M " is molar concentration.
Embodiment 1 is by the soup ingredients A:AgNO of following amount preparation for atomizing usefulness
30.3M, NH
3H
2O 0.15M, NaOH 0.1M, add go from
Sub-water to cumulative volume is 50 liters; Ingredients B: glucose 4M, HNO
30.1M, boiled 1~5 minute, cooling back adds ethanol
Make into 10M, volume is 5 liters.
Can use for non-weaving cloth atomizing spray-stain placing behind 10 parts of ingredients A+1 part ingredients B (V/V) mixing after 10~40 minutes, behind the atomizing spray-stain soup is evenly distributed on non-weaving cloth, enter reactor and carry out also adding continuously in chemistry and the physical treatment dispersant (OP-10) (under abundant ventilation condition), be pale brown look to non-weaving cloth, then through cleaning, centrifugal dehydration, be drying to obtain product of the present invention.
Embodiment 2 is by the soup ingredients A:AgNO of following amount preparation for atomizing usefulness
30.3M, NH
3H
2O 0.15M, NaOH 0.07M add distillation
Water to cumulative volume is 50 liters; Ingredients B: ascorbic acid 4M, HNO
30.1M, boiled 1~5 minute, cooling back adds second
Alcohol uses 10M, and volume is 5 liters.
Can use for non-weaving cloth atomizing spray-stain placing behind 10 parts of ingredients A+1 part ingredients B (V/V) mixing after 10~40 minutes.Behind the atomizing spray-stain soup is evenly distributed on non-weaving cloth, entering reactor handles, add the surfactant neopelex simultaneously continuously as dispersant (under ventilating), be pale brown look to non-weaving cloth, then through cleaning, centrifugal dehydration, be drying to obtain compound (Ag+Ag of the present invention
2O) anti-coagulation nano silver antibacterial non-woven.
Embodiment 3 is by the soup ingredients A:AgNO of following amount preparation for atomizing usefulness
30.1M, NH
3H
2O 0.08M, NaOH 0.05M, add distillation
Water to cumulative volume is 50 liters; Ingredients B: ascorbic acid 2M, HNO
30.11M, boiled 1~5 minute, cooling back adds
Ethanol makes into 6M, and volume is 5 liters.
Can use for non-weaving cloth atomizing spray-stain placing behind 10 parts of ingredients A+1 part ingredients B (V/V) mixing after 10~40 minutes, behind the atomizing spray-stain soup is evenly distributed on non-weaving cloth, enter reactor and carry out chemistry and physical treatment, add neopelex simultaneously continuously as dispersant (under ventilating), be pale brown look to non-weaving cloth, then through cleaning, centrifugal dehydration, be drying to obtain compound (Ag+Ag of the present invention
2O) anti-coagulation nano silver antibacterial non-woven.
Embodiment 4 is by the soup ingredients A:AgNO of following amount preparation for atomizing usefulness
30.1M, NH
3H
2O 0.08M, NaOH 0.05M, add steaming
Heating up in a steamer water is 50 liters totally extremely; Ingredients B: glucose 2M, HNO
30.11M, boiled 1~5 minute, cooling back adds second
Alcohol makes into 6M, and volume is 5 liters.
Can use for non-weaving cloth atomizing spray-stain placing behind 10 parts of ingredients A+1 part ingredients B (V/V) mixing after 10~40 minutes, behind the atomizing spray-stain soup is evenly distributed on non-weaving cloth, enter reactor and carry out chemistry and physical treatment, add the surfactant neopelex simultaneously continuously as dispersant (under ventilating), be pale brown look to non-weaving cloth, then through cleaning, centrifugal dehydration, be drying to obtain compound (Ag+Ag of the present invention
2O) anti-coagulation nano silver antibacterial non-woven.
Compound (Ag+Ag of the present invention
2O) the anti-coagulation nano silver antibacterial non-woven can be developed the medicinal functional product and the antibiotic health care type is main, can donor after clinical verification outside the medicinal functional dressing of antibacterial therapy body surface wound, become the first-selected product that substitutes antimicrobial and neutral dressing.Also relate to health care industry and non-weaving cloth industry simultaneously, as health care already used antimicrobial form, the non-weaving cloth of health in all kinds of medicinal functional non-weaving cloths of usefulness and each industry, the field.Table 1: contain the micro mist of anti-coagulation nano silver and the antibacterial result of 8 kinds of antibacterials
The micro mist antibacterials MIC method drug sensitivity tests that contains anti-coagulation nano silver
Originate with control group bacteriostatic diameter (mm) bacterium name
Wash cloudy red phenylamino head head celebrating ring
The mould azoles benzyl spore spore spore of washing property is big by third
Wash his mould sand of 50 100 pairs of elements cc azoles furan
ATCC25923 18 15 15 7 24 S S S S S S S ATCC25922 13 13 12 7 10 S S S S S S ATCC27853 12 12 12 7 6 S S S CMCC ( B ) 64606 10 ( MRSA ) 17 15 15 7 6 R R R R R R R ( MRSE ) 18 15 46 7 6 R R R R R R R 9 8 8 7 6 S S S S S S S 10 10 10 7 31 S S S S S S 17 14 14 7 6 R R R R R R 9 8 8 7 11 R R R R R R 14 12 13 7 6 R R R R R R 15 15 15 7 6 R R R R R R 14 13 14 7 6 R R R S R S 13 12 12 7 19 R R R S S S 15 14 14 7 6 R R R S R S 16 13 14 7 6 R R R R R S 11 10 11 7 6 R R R R R R 15 13 13 7 6 R R R S R S 13 11 13 7 16 R R R S R S 14 12 12 7 17 R I I S R S 17 15 15 7 6 R R R S I S 11 10 10 7 9 R R R S R R 11 9 11 7 6 R R R S R R 10 9 10 7 6 R R I S R S 21 20 20 7 6 18 17 18 7 6 20 19 20 7 6 27 26 26 7 6:S: I: R:2:AB20
The extracorporeal bacteria inhibitor test table of pathogenic strain
The AB fabric contains the micro mist of anti-coagulation nano silver
Blank
Bacterial strain
Not washing Gao Weigao washes
Fabric
Wash 20 and compress and wash 20 50
Inferior Pseudomonas aeruginosa---15 13 16 16 staphylococcus aureuses---15 17 15 15 Escherichia coli---13 14 18 15MRSA----14,14 17 15 wax-shaped bacillus---11 13 13 15 15 Vibrio vulnificus---16 16 16 16 Candida albicans-21--11 11 11 11B group hemolytic streptococcus---11 11 12 11 Pseudomonas Maltophilias---12 12 15 14 nitrate-negative bacillus---14 14 13 15 moscow' paratyphi Cs-12--12 14 19 14 Arizona bacterium---14 14 15 14 citrobacters---14 14 15 13 pneumobacilluses---13 13 17 13 hay bacilluses---12 12 12 12 morganella morganiis---10 12 12 12 12 alcaligenes faecalises---14 12 16 16 Si Shi Pu Tufeideng Salmonellas---12 12 14 13 enterobacter cloacaes---13 13 13 13 gonococcus----11 11 11 11
Above result shows that the micro mist that contains anti-coagulation nano silver all has inhibitory action to 20 strain bacteriums, and the bacterium that commute develops immunity to drugs, as staphylococcus aureus persister (MRSA), Pseudomonas aeruginosas etc. all have inhibitory action, high pressure and wash after 20 times and 50 times all with without the bacteriostasis of washing and do not have significant difference.The AB fabric is the disclosed fabric of CN87100231A.