CN1368292A - Nano medicing 'Wenzhong Zhixie' and its preparing process - Google Patents
Nano medicing 'Wenzhong Zhixie' and its preparing process Download PDFInfo
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- CN1368292A CN1368292A CN 01102650 CN01102650A CN1368292A CN 1368292 A CN1368292 A CN 1368292A CN 01102650 CN01102650 CN 01102650 CN 01102650 A CN01102650 A CN 01102650A CN 1368292 A CN1368292 A CN 1368292A
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Abstract
A nanometre (0.1-200 nm) medicine "Wenzhong Zhixie" for treating diarrhea is prepared from the nanometre powders of 23 Chinese medicinal materials including cyperus tuber, tengerine peel, haw, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to that a kind of spleen invigorating warming the stomach, removing food stagnancy are had a respite, pain relieving antidiarrheal nanometer warming middle-JIAO to stop diarrhea preparation medicine, the invention still further relates to the method for this medication preparation.
The warming middle-JIAO to stop diarrhea ball is a kind of classical Chinese patent medicine, mainly contains effects such as spleen invigorating warming the stomach, removing food stagnancy are had a respite, pain relieving antidiarrheal, is used for weakness of the spleen and stomach, dyspepsia flatulence, stomachache vomiting, cold-damp increased borborygmus and diarrhea.But traditional warming middle-JIAO to stop diarrhea ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer warming middle-JIAO to stop diarrhea preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer warming middle-JIAO to stop diarrhea preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano cyperus tuber 40-80 part nanometer Pericarpium Citri Reticulatae 40-80 part nanometer Massa Medicata Fermentata 40-80 part
Nanometer Herba Pogostemonis 40-80 part nanometer Fructus Crataegi 35-80 part nanometer Cortex Magnoliae Officinalis 35-80 part
Nanometer Rhizoma Atractylodis Macrocephalae 35-80 part nano pinellia 35-80 part nanometer Semen Lablab Album 35-80 part
Nano Poria 35-80 part nanometer Fructus Amomi 25-60 part nanometer Fructus Amomi Rotundus 25-60 part
Nanometer Fructus Hordei Germinatus 20-40 part nanometer Cortex Cinnamomi 20-40 part nanometer Rhizoma Atractylodis 20-40 part
Nanometer Radix Aucklandiae 20-40 part nanometer Rhizoma Alismatis 20-40 part nano clove 10-25 part
Nano angelica root 10-25 part nanometer Radix Glycyrrhizae 10-25 part nanometer Borneolum Syntheticum 4-9 part
Nanometric Herbra Asarum 2-8 part nanometer Rhizoma Zingiberis Recens 150-300 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano cyperus tuber 50-70 part nanometer Pericarpium Citri Reticulatae 50-70 part nanometer Massa Medicata Fermentata 50-70 part
Nanometer Herba Pogostemonis 50-70 part nanometer Fructus Crataegi 40-60 part nanometer Cortex Magnoliae Officinalis 40-60 part
Nanometer Rhizoma Atractylodis Macrocephalae 40-60 part nano pinellia 40-60 part nanometer Semen Lablab Album 40-60 part
Nano Poria 40-60 part nanometer Fructus Amomi 30-50 part nanometer Fructus Amomi Rotundus 30-50 part
Nanometer Fructus Hordei Germinatus 25-35 part nanometer Cortex Cinnamomi 25-35 part nanometer Rhizoma Atractylodis 25-35 part
Nanometer Radix Aucklandiae 25-35 part nanometer Rhizoma Alismatis 25-35 part nano clove 12-18 part
Nano angelica root 12-18 part nanometer Radix Glycyrrhizae 12-18 part nanometer Borneolum Syntheticum 5-9 part
Nanometric Herbra Asarum 2-5 part nanometer Rhizoma Zingiberis Recens 180-250 part
The optimum weight proportioning of medicine of the present invention is:
60 parts of 60 parts of nanometer Massa Medicata Fermentatas of 60 parts of nanometer Pericarpium Citri Reticulataes of nano cyperus tuber
48 parts of 48 parts of nanometer Cortex Magnoliae Officinalis of 60 parts of nanometer Fructus Crataegis of nanometer Herba Pogostemonis
48 parts of 48 portions of nanometer Semen Lablab Albums of 48 parts of nano pinellias of the nanometer Rhizoma Atractylodis Macrocephalae
36 parts in 36 parts of nanometer Fructus Amomi Rotunduss of 48 parts of nanometer Fructus Amomis of nano Poria
30 parts of 30 parts of nanometer Rhizoma Atractylodis of 30 parts of nanometer Cortex Cinnamomis of nanometer Fructus Hordei Germinatus
15 parts of 30 parts of nano cloves of 30 parts of nanometer Rhizoma Alismatis of the nanometer Radix Aucklandiae
7.3 parts of 15 parts of nanometer Borneolum Syntheticums of 15 parts of nanometer Radix Glycyrrhizaes of nano angelica root
212 parts in 3 portions of nanometer Rhizoma Zingiberis Recenss of nanometric Herbra Asarum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get warming middle-JIAO to stop diarrhea preparation nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer warming middle-JIAO to stop diarrhea preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common warming middle-JIAO to stop diarrhea pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nanometer warming middle-JIAO to stop diarrhea preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as weakness of the spleen and stomach, dyspepsia flatulence, stomachache vomiting, cold-damp increased borborygmus and diarrhea, and clinical efficacy significantly is better than traditional warming middle-JIAO to stop diarrhea ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
60 parts of 60 parts of nanometer Massa Medicata Fermentatas of 60 parts of nanometer Pericarpium Citri Reticulataes of nano cyperus tuber
48 parts of 48 parts of nanometer Cortex Magnoliae Officinalis of 60 parts of nanometer Fructus Crataegis of nanometer Herba Pogostemonis
48 parts of 48 portions of nanometer Semen Lablab Albums of 48 parts of nano pinellias of the nanometer Rhizoma Atractylodis Macrocephalae
36 parts in 36 parts of nanometer Fructus Amomi Rotunduss of 48 parts of nanometer Fructus Amomis of nano Poria
30 parts of 30 parts of nanometer Rhizoma Atractylodis of 30 parts of nanometer Cortex Cinnamomis of nanometer Fructus Hordei Germinatus
15 parts of 30 parts of nano cloves of 30 parts of nanometer Rhizoma Alismatis of the nanometer Radix Aucklandiae
7.3 parts of 15 parts of nanometer Borneolum Syntheticums of 15 parts of nanometer Radix Glycyrrhizaes of nano angelica root
212 parts in 3 portions of nanometer Rhizoma Zingiberis Recenss of nanometric Herbra Asarum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
60 parts of 60 parts of nanometer Massa Medicata Fermentatas of 60 parts of nanometer Pericarpium Citri Reticulataes of nano cyperus tuber
48 parts of 48 parts of nanometer Cortex Magnoliae Officinalis of 60 parts of nanometer Fructus Crataegis of nanometer Herba Pogostemonis
48 parts of 48 portions of nanometer Semen Lablab Albums of 48 parts of nano pinellias of the nanometer Rhizoma Atractylodis Macrocephalae
36 parts in 36 parts of nanometer Fructus Amomi Rotunduss of 48 parts of nanometer Fructus Amomis of nano Poria
30 parts of 30 parts of nanometer Rhizoma Atractylodis of 30 parts of nanometer Cortex Cinnamomis of nanometer Fructus Hordei Germinatus
15 parts of 30 parts of nano cloves of 30 parts of nanometer Rhizoma Alismatis of the nanometer Radix Aucklandiae
7.3 parts of 15 parts of nanometer Borneolum Syntheticums of 15 parts of nanometer Radix Glycyrrhizaes of nano angelica root
212 parts in 3 portions of nanometer Rhizoma Zingiberis Recenss of nanometric Herbra Asarum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer warming middle-JIAO to stop diarrhea powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
60 parts of 60 parts of nanometer Massa Medicata Fermentatas of 60 parts of nanometer Pericarpium Citri Reticulataes of nano cyperus tuber
48 parts of 48 parts of nanometer Cortex Magnoliae Officinalis of 60 parts of nanometer Fructus Crataegis of nanometer Herba Pogostemonis
48 parts of 48 portions of nanometer Semen Lablab Albums of 48 parts of nano pinellias of the nanometer Rhizoma Atractylodis Macrocephalae
36 parts in 36 parts of nanometer Fructus Amomi Rotunduss of 48 parts of nanometer Fructus Amomis of nano Poria
30 parts of 30 parts of nanometer Rhizoma Atractylodis of 30 parts of nanometer Cortex Cinnamomis of nanometer Fructus Hordei Germinatus
15 parts of 30 parts of nano cloves of 30 parts of nanometer Rhizoma Alismatis of the nanometer Radix Aucklandiae
7.3 parts of 15 parts of nanometer Borneolum Syntheticums of 15 parts of nanometer Radix Glycyrrhizaes of nano angelica root
212 parts in 3 portions of nanometer Rhizoma Zingiberis Recenss of nanometric Herbra Asarum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer warming middle-JIAO to stop diarrhea membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer warming middle-JIAO to stop diarrhea preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano cyperus tuber 40-80 part nanometer Pericarpium Citri Reticulatae 40-80 part nanometer Massa Medicata Fermentata 40-80 part
Nanometer Herba Pogostemonis 40-80 part nanometer Fructus Crataegi 35-80 part nanometer Cortex Magnoliae Officinalis 35-80 part
Nanometer Rhizoma Atractylodis Macrocephalae 35-80 part nano pinellia 35-80 part nanometer Semen Lablab Album 35-80 part
Nano Poria 35-80 part nanometer Fructus Amomi 25-60 part nanometer Fructus Amomi Rotundus 25-60 part
Nanometer Fructus Hordei Germinatus 20-40 part nanometer Cortex Cinnamomi 20-40 part nanometer Rhizoma Atractylodis 20-40 part
Nanometer Radix Aucklandiae 20-40 part nanometer Rhizoma Alismatis 20-40 part nano clove 10-25 part
Nano angelica root 10-25 part nanometer Radix Glycyrrhizae 10-25 part nanometer Borneolum Syntheticum 4-9 part
Nanometric Herbra Asarum 2-8 part nanometer Rhizoma Zingiberis Recens 150-300 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer warming middle-JIAO to stop diarrhea preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano cyperus tuber 50-70 part nanometer Pericarpium Citri Reticulatae 50-70 part nanometer Massa Medicata Fermentata 50-70 part
Nanometer Herba Pogostemonis 50-70 part nanometer Fructus Crataegi 40-60 part nanometer Cortex Magnoliae Officinalis 40-60 part
Nanometer Rhizoma Atractylodis Macrocephalae 40-60 part nano pinellia 40-60 part nanometer Semen Lablab Album 40-60 part
Nano Poria 40-60 part nanometer Fructus Amomi 30-50 part nanometer Fructus Amomi Rotundus 30-50 part
Nanometer Fructus Hordei Germinatus 25-35 part nanometer Cortex Cinnamomi 25-35 part nanometer Rhizoma Atractylodis 25-35 part
Nanometer Radix Aucklandiae 25-35 part nanometer Rhizoma Alismatis 25-35 part nano clove 12-18 part
Nano angelica root 12-18 part nanometer Radix Glycyrrhizae 12-18 part nanometer Borneolum Syntheticum 5-9 part
Nanometric Herbra Asarum 2-5 part nanometer Rhizoma Zingiberis Recens 180-250 part
3, nanometer warming middle-JIAO to stop diarrhea preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
60 parts of 60 parts of nanometer Massa Medicata Fermentatas of 60 parts of nanometer Pericarpium Citri Reticulataes of nano cyperus tuber
48 parts of 48 parts of nanometer Cortex Magnoliae Officinalis of 60 parts of nanometer Fructus Crataegis of nanometer Herba Pogostemonis
48 parts of 48 portions of nanometer Semen Lablab Albums of 48 parts of nano pinellias of the nanometer Rhizoma Atractylodis Macrocephalae
36 parts in 36 parts of nanometer Fructus Amomi Rotunduss of 48 parts of nanometer Fructus Amomis of nano Poria
30 parts of 30 parts of nanometer Rhizoma Atractylodis of 30 parts of nanometer Cortex Cinnamomis of nanometer Fructus Hordei Germinatus
15 parts of 30 parts of nano cloves of 30 parts of nanometer Rhizoma Alismatis of the nanometer Radix Aucklandiae
7.3 parts of 15 parts of nanometer Borneolum Syntheticums of 15 parts of nanometer Radix Glycyrrhizaes of nano angelica root
212 parts in 3 portions of nanometer Rhizoma Zingiberis Recenss of nanometric Herbra Asarum
4, according to claim 1 or 2 or 3 described nanometer warming middle-JIAO to stop diarrhea preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer warming middle-JIAO to stop diarrhea preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102650 CN1368292A (en) | 2001-02-06 | 2001-02-06 | Nano medicing 'Wenzhong Zhixie' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102650 CN1368292A (en) | 2001-02-06 | 2001-02-06 | Nano medicing 'Wenzhong Zhixie' and its preparing process |
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| CN1368292A true CN1368292A (en) | 2002-09-11 |
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| CN 01102650 Pending CN1368292A (en) | 2001-02-06 | 2001-02-06 | Nano medicing 'Wenzhong Zhixie' and its preparing process |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225139A (en) * | 2011-06-27 | 2011-10-26 | 广州市荔湾区中医医院 | Chenshu invigorating spleen paste and its preparation method |
| CN102309550A (en) * | 2010-07-06 | 2012-01-11 | 中国人民解放军第三○二医院 | Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof |
| CN102614348A (en) * | 2012-03-31 | 2012-08-01 | 李金梅 | Chinese medicine for treating cold-damp affecting spleen diarrhea |
| CN103585601A (en) * | 2013-11-09 | 2014-02-19 | 河南科技学院 | Veterinary medicine for treating pig diarrhea caused by deficiency-cold in spleen and stomach |
| WO2015149390A1 (en) * | 2014-03-31 | 2015-10-08 | 袁志贤 | Traditional chinese medicine oral liquid for treating chronic enteritis and preparation method therefor |
| CN108175814A (en) * | 2017-12-30 | 2018-06-19 | 广东名辰堂健康产业股份有限公司 | A kind of powder for treating baby diarrhea and preparation method thereof |
-
2001
- 2001-02-06 CN CN 01102650 patent/CN1368292A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309550A (en) * | 2010-07-06 | 2012-01-11 | 中国人民解放军第三○二医院 | Traditional Chinese medicinal aerosol for preventing and treating summer humidity disease and preparation method thereof |
| CN102225139A (en) * | 2011-06-27 | 2011-10-26 | 广州市荔湾区中医医院 | Chenshu invigorating spleen paste and its preparation method |
| CN102225139B (en) * | 2011-06-27 | 2012-06-27 | 广州市荔湾区中医医院 | Chenshu invigorating spleen paste and its preparation method |
| CN102614348A (en) * | 2012-03-31 | 2012-08-01 | 李金梅 | Chinese medicine for treating cold-damp affecting spleen diarrhea |
| CN103585601A (en) * | 2013-11-09 | 2014-02-19 | 河南科技学院 | Veterinary medicine for treating pig diarrhea caused by deficiency-cold in spleen and stomach |
| WO2015149390A1 (en) * | 2014-03-31 | 2015-10-08 | 袁志贤 | Traditional chinese medicine oral liquid for treating chronic enteritis and preparation method therefor |
| CN108175814A (en) * | 2017-12-30 | 2018-06-19 | 广东名辰堂健康产业股份有限公司 | A kind of powder for treating baby diarrhea and preparation method thereof |
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