CN1368183A - Nano medicine for treating diseases due to summer heat and its preparing process - Google Patents
Nano medicine for treating diseases due to summer heat and its preparing process Download PDFInfo
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- CN1368183A CN1368183A CN 01102510 CN01102510A CN1368183A CN 1368183 A CN1368183 A CN 1368183A CN 01102510 CN01102510 CN 01102510 CN 01102510 A CN01102510 A CN 01102510A CN 1368183 A CN1368183 A CN 1368183A
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Abstract
A nanometre (0.1-200 nm) medicine for treating summer-heat diseases is prepared from the nanometre powders of 15 Chinese medicinal materials including asarum sieboldii, mint, agastache, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of cold relieving and ward off the nano medicine for treating diseases due to summer heat of pestilence, dissolving turbidity for resucitation, the invention still further relates to the method for this medication preparation.
Summer-heat disease sheet is a kind of classical Chinese patent medicine, mainly contain analgesic, eliminate the phlegm, suppress effects such as neural excitation, lax gastrointestinal smooth muscle, be used for that summertime attacked by pestiferous factors, faintness, gnathospasma, stomachache are vomited and diarrhoea, extremity are numb.But traditional summer-heat disease sheet disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine for treating diseases due to summer heat of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine for treating diseases due to summer heat.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Fructus Gleditsiae Abnormalis 50-120 part nanometric Herbra Asarum 50-120 part nanometer Herba Menthae 40-90 part
Nanometer Herba Pogostemonis 30-90 part nanometer Radix Aucklandiae 30-90 part nano angelica root 10-50 part
Nanometer Radix Saposhnikoviae 30-80 part nanometer Pericarpium Citri Reticulatae 25-80 part nano pinellia 25-80 part
Nanometer Radix Platycodonis 25-90 part nanometer Radix Glycyrrhizae 25-90 part nanometer Rhizoma Osmundae 25-90 part
Nanometer Alumen 12-50 part nanometer-size realgar 30-80 part nanometer Cinnabaris 30-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Fructus Gleditsiae Abnormalis 60-100 part nanometric Herbra Asarum 60-100 part nanometer Herba Menthae 50-80 part
Nanometer Herba Pogostemonis 35-80 part nanometer Radix Aucklandiae 40-70 part nano angelica root 15-40 part
Nanometer Radix Saposhnikoviae 40-70 part nanometer Pericarpium Citri Reticulatae 30-70 part nano pinellia 30-70 part
Nanometer Radix Platycodonis 30-70 part nanometer Radix Glycyrrhizae 30-70 part nanometer Rhizoma Osmundae 30-70 part
Nanometer Alumen 15-40 part nanometer-size realgar 40-70 part nanometer Cinnabaris 40-70 part
The optimum weight proportioning of medicine of the present invention is:
69 parts of 80 parts of nanometer Herba Menthaes of 80 parts of nanometric Herbra Asarums of nanometer Fructus Gleditsiae Abnormalis
23 parts of 46 parts of nano angelica roots of 46 parts of nanometer Radix Aucklandiae of nanometer Herba Pogostemonis
46 parts of 46 parts of nano pinellias of 46 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Saposhnikoviae
46 parts of 46 parts of nanometer Rhizoma Osmundae of 46 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
57 parts in 57 parts of nanometer Cinnabaris of 23 parts of nanometer-size realgars of nanometer Alumen
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure, instantaneous with the hypersonic velocity jet in dry, get summer-heat disease preparation nano powder;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine for treating diseases due to summer heat is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common summer-heat disease tablet preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine for treating diseases due to summer heat etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the treatment of conditions such as disease of suffering heatstroke summer, and clinical efficacy significantly is better than traditional summer-heat disease sheet.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
69 parts of 80 parts of nanometer Herba Menthaes of 80 parts of nanometric Herbra Asarums of nanometer Fructus Gleditsiae Abnormalis
23 parts of 46 parts of nano angelica roots of 46 parts of nanometer Radix Aucklandiae of nanometer Herba Pogostemonis
46 parts of 46 parts of nano pinellias of 46 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Saposhnikoviae
46 parts of 46 parts of nanometer Rhizoma Osmundae of 46 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
57 parts in 57 parts of nanometer Cinnabaris of 23 parts of nanometer-size realgars of nanometer Alumen
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
69 parts of 80 parts of nanometer Herba Menthaes of 80 parts of nanometric Herbra Asarums of nanometer Fructus Gleditsiae Abnormalis
23 parts of 46 parts of nano angelica roots of 46 parts of nanometer Radix Aucklandiae of nanometer Herba Pogostemonis
46 parts of 46 parts of nano pinellias of 46 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Saposhnikoviae
46 parts of 46 parts of nanometer Rhizoma Osmundae of 46 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
57 parts in 57 parts of nanometer Cinnabaris of 23 parts of nanometer-size realgars of nanometer Alumen
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer summer-heat disease powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
69 parts of 80 parts of nanometer Herba Menthaes of 80 parts of nanometric Herbra Asarums of nanometer Fructus Gleditsiae Abnormalis
23 parts of 46 parts of nano angelica roots of 46 parts of nanometer Radix Aucklandiae of nanometer Herba Pogostemonis
46 parts of 46 parts of nano pinellias of 46 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Saposhnikoviae
46 parts of 46 parts of nanometer Rhizoma Osmundae of 46 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
57 parts in 57 parts of nanometer Cinnabaris of 23 parts of nanometer-size realgars of nanometer Alumen
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer summer-heat disease membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, chest.
Claims (6)
1, a kind of nano medicine for treating diseases due to summer heat is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Fructus Gleditsiae Abnormalis 50-120 part nanometric Herbra Asarum 50-120 part nanometer Herba Menthae 40-90 part
Nanometer Herba Pogostemonis 30-90 part nanometer Radix Aucklandiae 30-90 part nano angelica root 10-50 part
Nanometer Radix Saposhnikoviae 30-80 part nanometer Pericarpium Citri Reticulatae 25-80 part nano pinellia 25-80 part
Nanometer Radix Platycodonis 25-90 part nanometer Radix Glycyrrhizae 25-90 part nanometer Rhizoma Osmundae 25-90 part
Nanometer Alumen 12-50 part nanometer-size realgar 30-80 part nanometer Cinnabaris 30-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine for treating diseases due to summer heat according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Fructus Gleditsiae Abnormalis 60-100 part nanometric Herbra Asarum 60-100 part nanometer Herba Menthae 50-80 part
Nanometer Herba Pogostemonis 35-80 part nanometer Radix Aucklandiae 40-70 part nano angelica root 15-40 part
Nanometer Radix Saposhnikoviae 40-70 part nanometer Pericarpium Citri Reticulatae 30-70 part nano pinellia 30-70 part
Nanometer Radix Platycodonis 30-70 part nanometer Radix Glycyrrhizae 30-70 part nanometer Rhizoma Osmundae 30-70 part
Nanometer Alumen 15-40 part nanometer-size realgar 40-70 part nanometer Cinnabaris 40-70 part
3, nano medicine for treating diseases due to summer heat according to claim 1, wherein the weight proportion of each nano raw material is:
69 parts of 80 parts of nanometer Herba Menthaes of 80 parts of nanometric Herbra Asarums of nanometer Fructus Gleditsiae Abnormalis
23 parts of 46 parts of nano angelica roots of 46 parts of nanometer Radix Aucklandiae of nanometer Herba Pogostemonis
46 parts of 46 parts of nano pinellias of 46 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Saposhnikoviae
46 parts of 46 parts of nanometer Rhizoma Osmundae of 46 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Platycodonis
57 parts in 57 parts of nanometer Cinnabaris of 23 parts of nanometer-size realgars of nanometer Alumen
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine for treating diseases due to summer heat.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine for treating diseases due to summer heat; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102510 CN1368183A (en) | 2001-01-31 | 2001-01-31 | Nano medicine for treating diseases due to summer heat and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01102510 CN1368183A (en) | 2001-01-31 | 2001-01-31 | Nano medicine for treating diseases due to summer heat and its preparing process |
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| CN1368183A true CN1368183A (en) | 2002-09-11 |
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| CN 01102510 Pending CN1368183A (en) | 2001-01-31 | 2001-01-31 | Nano medicine for treating diseases due to summer heat and its preparing process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100402054C (en) * | 2005-12-29 | 2008-07-16 | 徐明学 | Medicine for treating heatstroke and its preparation method |
| CN112353885A (en) * | 2020-11-23 | 2021-02-12 | 浩凤利 | First-aid powder for opening cavity and restoring consciousness and preparation method thereof |
-
2001
- 2001-01-31 CN CN 01102510 patent/CN1368183A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100402054C (en) * | 2005-12-29 | 2008-07-16 | 徐明学 | Medicine for treating heatstroke and its preparation method |
| CN112353885A (en) * | 2020-11-23 | 2021-02-12 | 浩凤利 | First-aid powder for opening cavity and restoring consciousness and preparation method thereof |
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