CN1365758A - Nano antitussive phlegm-resolving medicine and its preparing process - Google Patents
Nano antitussive phlegm-resolving medicine and its preparing process Download PDFInfo
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- CN1365758A CN1365758A CN 01100859 CN01100859A CN1365758A CN 1365758 A CN1365758 A CN 1365758A CN 01100859 CN01100859 CN 01100859 CN 01100859 A CN01100859 A CN 01100859A CN 1365758 A CN1365758 A CN 1365758A
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Abstract
A nanometre medicine "Zhishou Huatan" is prepared from the nanometre powders of 25 Chinese medicinal materials including poppy capsule, platycodon root, anemarrhena rhizome peucedanum root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano antitussive phlegm-resolving medicine of a kind of removing heat from the lung and dissipating phlegm, relieving cough, relieving asthma, the invention still further relates to the method for this medication preparation.
The antitussive phlegm-resolving pill is a kind of classical Chinese patent medicine, mainly contains effects such as removing heat from the lung and dissipating phlegm, relieving cough, relieving asthma, is used for accumulation of phlegm-heat in the lung, chronic cough, hemoptysis, phlegm dyspnea QI rising in reverse order, the sleeplessness of panting.But traditional antitussive phlegm-resolving pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano antitussive phlegm-resolving medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano antitussive phlegm-resolving medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Pericarpium Papaveris 400-800 part nanometer Radix Platycodonis 150-350 part nanometer Rhizoma Anemarrhenae 80-180 part
Nanometer Radix Peucedani 80-180 part nanometer Pericarpium Citri Reticulatae 80-180 part nano rhubarb 80-180 part
The female 80-180 part of nanometer Radix Glycyrrhizae 80-180 part nano Sichuan fritillary bulb nanometer Gypsum Fibrosum 150-400 part
Nanometer Semen Armeniacae Amarum 100-300 part nanometer Folium Perillae 80-180 part nanometer Semen Lepidii (Semen Descurainiae) 80-180 part
Nanometer Flos Farfarae 80-180 part nanometer Radix Stemonae 80-180 part nanometer Radix Scrophulariae 80-180 part
Nanometer 80-180 Radix Ophiopogonis part nanometer Flos Buddlejae 50-95 part nanometer Radix Asparagi 80-180 part
Nanometer Fructus Schisandrae Chinensis 50-95 part nanometer Fructus Aurantii 80-180 part nanometer Semen Fructus Trichosanthis 80-180 part
Nano pinellia 150-450 part nanometer Radix Aucklandiae 50-95 part nanometer Fructus Aristolochiae 80-180 part
Nanometer Folium Mori 80-180 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Pericarpium Papaveris 500-700 part nanometer Radix Platycodonis 200-300 part nanometer Rhizoma Anemarrhenae 100-150 part
Nanometer Radix Peucedani 100-150 part nanometer Pericarpium Citri Reticulatae 100-150 part nano rhubarb 100-150 part
The female 100-150 part of nanometer Radix Glycyrrhizae 100-150 part nano Sichuan fritillary bulb nanometer Gypsum Fibrosum 200-300 part
Nanometer Semen Armeniacae Amarum 150-250 part nanometer Folium Perillae 100-150 part nanometer Semen Lepidii (Semen Descurainiae) 100-145 part
Nanometer Flos Farfarae 100-150 part nanometer Radix Stemonae 100-150 part nanometer Radix Scrophulariae 100-150 part
Nanometer 100-150 Radix Ophiopogonis part nanometer Flos Buddlejae 60-90 part nanometer Radix Asparagi 100-150 part
Nanometer Fructus Schisandrae Chinensis 60-90 part nanometer Fructus Aurantii 100-150 part nanometer Semen Fructus Trichosanthis 100-150 part
Nano pinellia 200-300 part nanometer Radix Aucklandiae 60-90 part nanometer Fructus Aristolochiae 100-150 part
Nanometer Folium Mori 100-150 part
The optimum weight proportioning of medicine of the present invention is:
125 parts of 250 parts of nanometer Rhizoma Anemarrhenaes of 625 parts of nanometer Radix Platycodoniss of nanometer Pericarpium Papaveris
125 parts of 125 parts of nano rhubarbs of 125 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
250 parts in the female 125 parts of nanometer Gypsum Fibrosum of 125 parts of nano Sichuan fritillary bulbs of nanometer Radix Glycyrrhizae
125 parts of 125 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 187.5 parts of nanometer Folium Perillaes of nanometer Semen Armeniacae Amarum
125 parts of 125 portions of nanometer Radix Scrophulariaes of 125 parts of nanometer Radixs Stemonae of nanometer Flos Farfarae
125 parts of 75 parts of nanometer Radix Asparagis of nanometer 125 parts of nanometer Flos Buddlejaes Radix Ophiopogonis
125 parts of 125 parts of nanometer Semen Fructus Trichosanthis of 75 parts of nanometer Fructus Aurantiis of nanometer Fructus Schisandrae Chinensis
125 parts of 75 parts of nanometer Fructus Aristolochiaes of 250 parts of nanometer Radix Aucklandiae of nano pinellia
125 parts on nanometer Folium Mori
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the antitussive phlegm-resolving nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano antitussive phlegm-resolving medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common antitussive phlegm-resolving pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano antitussive phlegm-resolving medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as accumulation of phlegm-heat in the lung, chronic cough, hemoptysis, phlegm dyspnea QI rising in reverse order, the sleeplessness of panting, and clinical efficacy significantly is better than traditional antitussive phlegm-resolving pill.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
125 parts of 250 parts of nanometer Rhizoma Anemarrhenaes of 625 parts of nanometer Radix Platycodoniss of nanometer Pericarpium Papaveris
125 parts of 125 parts of nano rhubarbs of 125 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
250 parts in the female 125 parts of nanometer Gypsum Fibrosum of 125 parts of nano Sichuan fritillary bulbs of nanometer Radix Glycyrrhizae
125 parts of 125 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 187.5 parts of nanometer Folium Perillaes of nanometer Semen Armeniacae Amarum
125 parts of 125 portions of nanometer Radix Scrophulariaes of 125 parts of nanometer Radixs Stemonae of nanometer Flos Farfarae
125 parts of 75 parts of nanometer Radix Asparagis of nanometer 125 parts of nanometer Flos Buddlejaes Radix Ophiopogonis
125 parts of 125 parts of nanometer Semen Fructus Trichosanthis of 75 parts of nanometer Fructus Aurantiis of nanometer Fructus Schisandrae Chinensis
125 parts of 75 parts of nanometer Fructus Aristolochiaes of 250 parts of nanometer Radix Aucklandiae of nano pinellia
125 parts on nanometer Folium Mori
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
125 parts of 250 parts of nanometer Rhizoma Anemarrhenaes of 625 parts of nanometer Radix Platycodoniss of nanometer Pericarpium Papaveris
125 parts of 125 parts of nano rhubarbs of 125 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
250 parts in the female 125 parts of nanometer Gypsum Fibrosum of 125 parts of nano Sichuan fritillary bulbs of nanometer Radix Glycyrrhizae
125 parts of 125 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 187.5 parts of nanometer Folium Perillaes of nanometer Semen Armeniacae Amarum
125 parts of 125 portions of nanometer Radix Scrophulariaes of 125 parts of nanometer Radixs Stemonae of nanometer Flos Farfarae
125 parts of 75 parts of nanometer Radix Asparagis of nanometer 125 parts of nanometer Flos Buddlejaes Radix Ophiopogonis
125 parts of 125 parts of nanometer Semen Fructus Trichosanthis of 75 parts of nanometer Fructus Aurantiis of nanometer Fructus Schisandrae Chinensis
125 parts of 75 parts of nanometer Fructus Aristolochiaes of 250 parts of nanometer Radix Aucklandiae of nano pinellia
125 parts on nanometer Folium Mori
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making reduce phlegm powder needle injection, every injection content of nanometer antitussive is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
125 parts of 250 parts of nanometer Rhizoma Anemarrhenaes of 625 parts of nanometer Radix Platycodoniss of nanometer Pericarpium Papaveris
125 parts of 125 parts of nano rhubarbs of 125 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
250 parts in the female 125 parts of nanometer Gypsum Fibrosum of 125 parts of nano Sichuan fritillary bulbs of nanometer Radix Glycyrrhizae
125 parts of 125 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 187.5 parts of nanometer Folium Perillaes of nanometer Semen Armeniacae Amarum
125 parts of 125 portions of nanometer Radix Scrophulariaes of 125 parts of nanometer Radixs Stemonae of nanometer Flos Farfarae
125 parts of 75 parts of nanometer Radix Asparagis of nanometer 125 parts of nanometer Flos Buddlejaes Radix Ophiopogonis
125 parts of 125 parts of nanometer Semen Fructus Trichosanthis of 75 parts of nanometer Fructus Aurantiis of nanometer Fructus Schisandrae Chinensis
125 parts of 75 parts of nanometer Fructus Aristolochiaes of 250 parts of nanometer Radix Aucklandiae of nano pinellia
125 parts on nanometer Folium Mori
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer antitussive membrane that reduces phlegm, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano antitussive phlegm-resolving medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Pericarpium Papaveris 400-800 part nanometer Radix Platycodonis 150-350 part nanometer Rhizoma Anemarrhenae 80-180 part
Nanometer Radix Peucedani 80-180 part nanometer Pericarpium Citri Reticulatae 80-180 part nano rhubarb 80-180 part
The female 80-180 part of nanometer Radix Glycyrrhizae 80-180 part nano Sichuan fritillary bulb nanometer Gypsum Fibrosum 150-400 part
Nanometer Semen Armeniacae Amarum 100-300 part nanometer Folium Perillae 80-180 part nanometer Semen Lepidii (Semen Descurainiae) 80-180 part
Nanometer Flos Farfarae 80-180 part nanometer Radix Stemonae 80-180 part nanometer Radix Scrophulariae 80-180 part
Nanometer 80-180 Radix Ophiopogonis part nanometer Flos Buddlejae 50-95 part nanometer Radix Asparagi 80-180 part
Nanometer Fructus Schisandrae Chinensis 50-95 part nanometer Fructus Aurantii 80-180 part nanometer Semen Fructus Trichosanthis 80-180 part
Nano pinellia 150-450 part nanometer Radix Aucklandiae 50-95 part nanometer Fructus Aristolochiae 80-180 part
Nanometer Folium Mori 80-180 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano antitussive phlegm-resolving medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Pericarpium Papaveris 500-700 part nanometer Radix Platycodonis 200-300 part nanometer Rhizoma Anemarrhenae 100-150 part
Nanometer Radix Peucedani 100-150 part nanometer Pericarpium Citri Reticulatae 100-150 part nano rhubarb 100-150 part
The female 100-150 part of nanometer Radix Glycyrrhizae 100-150 part nano Sichuan fritillary bulb nanometer Gypsum Fibrosum 200-300 part
Nanometer Semen Armeniacae Amarum 150-250 part nanometer Folium Perillae 100-150 part nanometer Semen Lepidii (Semen Descurainiae) 100-145 part
Nanometer Flos Farfarae 100-150 part nanometer Radix Stemonae 100-150 part nanometer Radix Scrophulariae 100-150 part
Nanometer 100-150 Radix Ophiopogonis part nanometer Flos Buddlejae 60-90 part nanometer Radix Asparagi 100-150 part
Nanometer Fructus Schisandrae Chinensis 60-90 part nanometer Fructus Aurantii 100-150 part nanometer Semen Fructus Trichosanthis 100-150 part
Nano pinellia 200-300 part nanometer Radix Aucklandiae 60-90 part nanometer Fructus Aristolochiae 100-150 part
Nanometer Folium Mori 100-150 part
3, nano antitussive phlegm-resolving medicine according to claim 1, wherein the weight proportion of each nano raw material is:
125 parts of 250 parts of nanometer Rhizoma Anemarrhenaes of 625 parts of nanometer Radix Platycodoniss of nanometer Pericarpium Papaveris
125 parts of 125 parts of nano rhubarbs of 125 parts of nanometer Pericarpium Citri Reticulataes of nanometer Radix Peucedani
250 parts in the female 125 parts of nanometer Gypsum Fibrosum of 125 parts of nano Sichuan fritillary bulbs of nanometer Radix Glycyrrhizae
125 parts of 125 parts of nanometer Semen Lepidii (Semen Descurainiae)s of 187.5 parts of nanometer Folium Perillaes of nanometer Semen Armeniacae Amarum
125 parts of 125 portions of nanometer Radix Scrophulariaes of 125 parts of nanometer Radixs Stemonae of nanometer Flos Farfarae
125 parts of 75 parts of nanometer Radix Asparagis of nanometer 125 parts of nanometer Flos Buddlejaes Radix Ophiopogonis
125 parts of 125 parts of nanometer Semen Fructus Trichosanthis of 75 parts of nanometer Fructus Aurantiis of nanometer Fructus Schisandrae Chinensis
125 parts of 75 parts of nanometer Fructus Aristolochiaes of 250 parts of nanometer Radix Aucklandiae of nano pinellia
125 parts on nanometer Folium Mori
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano antitussive phlegm-resolving medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano antitussive phlegm-resolving medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100859 CN1365758A (en) | 2001-01-19 | 2001-01-19 | Nano antitussive phlegm-resolving medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100859 CN1365758A (en) | 2001-01-19 | 2001-01-19 | Nano antitussive phlegm-resolving medicine and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365758A true CN1365758A (en) | 2002-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100859 Pending CN1365758A (en) | 2001-01-19 | 2001-01-19 | Nano antitussive phlegm-resolving medicine and its preparing process |
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| CN (1) | CN1365758A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886009A (en) * | 2012-10-30 | 2013-01-23 | 唐雯 | Chinese herba preparation with effect of preventing phlegm from forming and stopping coughing |
| CN104840854A (en) * | 2015-05-27 | 2015-08-19 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine for relieving cough and reducing sputum and preparation method of traditional Chinese medicine |
-
2001
- 2001-01-19 CN CN 01100859 patent/CN1365758A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102886009A (en) * | 2012-10-30 | 2013-01-23 | 唐雯 | Chinese herba preparation with effect of preventing phlegm from forming and stopping coughing |
| CN102886009B (en) * | 2012-10-30 | 2014-03-26 | 滨州医学院附属医院 | Chinese herba preparation with effect of preventing phlegm from forming and stopping coughing |
| CN104840854A (en) * | 2015-05-27 | 2015-08-19 | 南京同仁堂药业有限责任公司 | Traditional Chinese medicine for relieving cough and reducing sputum and preparation method of traditional Chinese medicine |
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