CN1363302A - Nano medicine 'Fangfeng Tongsheng' and its preparing process - Google Patents
Nano medicine 'Fangfeng Tongsheng' and its preparing process Download PDFInfo
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- CN1363302A CN1363302A CN 01100225 CN01100225A CN1363302A CN 1363302 A CN1363302 A CN 1363302A CN 01100225 CN01100225 CN 01100225 CN 01100225 A CN01100225 A CN 01100225A CN 1363302 A CN1363302 A CN 1363302A
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Abstract
A nano medicine "Fangfeng Tongsheng" is prepared from the nano powders of 17 Chinese-medicinal materials including ledebouriella root, schizone peta ear, mint, ephedra, etc through proportioning, microwave extracting, racuum concentrating and supersonic-jet spray drying. Its advantages include high biologic utilization rate and high curative effect.
Description
The present invention relates to a kind of dispelling wind to relieve the exterior syndrome, purging heat to relax the bowels, cure mainly wind heat and stop up to contain, excess in both the exterior and interior, sore swollen toxin, hemorrhoidal hamorrhage anal fistula, the nano medicine ' Fangfeng Tongsheng ' of red speckle urticaria the invention still further relates to the method for this medication preparation.
Fangfeng tongsheng pill is a kind of classical Chinese patent medicine, mainly contain have antibiotic, antiviral, analgesic, analgesia, antiinflammatory, antiallergic is regulated immunity, rushes down inferior effect, is used for wind heat and stops up and contain excess in both the exterior and interior, sore swollen toxin, hemorrhoidal hamorrhage anal fistula, red speckle urticaria etc.But traditional fangfeng tongsheng pill absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Fangfeng Tongsheng ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Fangfeng Tongsheng '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Radix Saposhnikoviae 28-72 part nanometer Herba Schizonepetae 15-35 part nanometer Herba Menthae 28-72 part
Nanometer Herba Ephedrae 28-72 part nano rhubarb 28-72 part nanometer Natrii Sulfas 28-72 part
Nanometer Fructus Gardeniae 15-35 part nanometer Talcum 200-400 part nanometer Radix Platycodonis 60-140 part
Nanometer Gypsum Fibrosum 60-140 part nanometer Rhizoma Chuanxiong 28-72 part nano Chinese angelica 28-72 part
Nanometer Radix Paeoniae Alba 28-72 part nanometer Radix Scutellariae 60-140 part nanometer Fructus Forsythiae 28-72 part
Nanometer Radix Glycyrrhizae 120-280 part nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 15-35 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Saposhnikoviae 40-60 part nanometer Herba Schizonepetae 20-30 part nanometer Herba Menthae 40-60 part
Nanometer Herba Ephedrae 40-60 part nano rhubarb 40-60 part nanometer Natrii Sulfas 40-60 part
Nanometer Fructus Gardeniae 20-30 part nanometer Talcum 250-350 part nanometer Radix Platycodonis 80-120 part
Nanometer Gypsum Fibrosum 80-120 part nanometer Rhizoma Chuanxiong 40-60 part nano Chinese angelica 40-60 part
Nanometer Radix Paeoniae Alba 40-60 part nanometer Radix Scutellariae 80-120 part nanometer Fructus Forsythiae 40-60 part
Nanometer Radix Glycyrrhizae 160-240 part nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 20-30 part
The optimum weight proportioning of medicine of the present invention is:
50 parts of 25 parts of nanometer Herba Menthaes of 50 parts of nanometer Herba Schizonepetaes of nanometer Radix Saposhnikoviae
50 parts in 50 parts of nanometer Natrii Sulfas of 50 parts of nano rhubarbs of nanometer Herba Ephedrae
100 parts of 300 parts of nanometer Radix Platycodoniss of 25 parts of nanometer Talcums of nanometer Fructus Gardeniae
50 parts of 50 parts of nano Chinese angelicas of 100 parts of nanometer Rhizoma Chuanxiongs of nanometer Gypsum Fibrosum
50 parts of 100 parts of nanometer Fructus Forsythiaes of 50 parts of nanometer Radix Scutellariaes of the nanometer Radix Paeoniae Alba
25 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Glycyrrhizae (stir-fry)
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Fangfeng Tongsheng ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Fangfeng Tongsheng ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common fangfeng tongsheng pill preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Fangfeng Tongsheng ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for headache, infectious disease, dermatosis, treatment of conditions such as obesity, the traditional fangfeng tongsheng pill of the remarkable excellent son of clinical efficacy.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
50 parts of 25 parts of nanometer Herba Menthaes of 50 parts of nanometer Herba Schizonepetaes of nanometer Radix Saposhnikoviae
50 parts in 50 parts of nanometer Natrii Sulfas of 50 parts of nano rhubarbs of nanometer Herba Ephedrae
100 parts of 300 parts of nanometer Radix Platycodoniss of 25 parts of nanometer Talcums of nanometer Fructus Gardeniae
50 parts of 50 parts of nano Chinese angelicas of 100 parts of nanometer Rhizoma Chuanxiongs of nanometer Gypsum Fibrosum
50 parts of 100 parts of nanometer Fructus Forsythiaes of 50 parts of nanometer Radix Scutellariaes of the nanometer Radix Paeoniae Alba
25 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Glycyrrhizae (stir-fry)
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
50 parts of 25 parts of nanometer Herba Menthaes of 50 parts of nanometer Herba Schizonepetaes of nanometer Radix Saposhnikoviae
50 parts in 50 parts of nanometer Natrii Sulfas of 50 parts of nano rhubarbs of nanometer Herba Ephedrae
100 parts of 300 parts of nanometer Radix Platycodoniss of 25 parts of nanometer Talcums of nanometer Fructus Gardeniae
50 parts of 50 parts of nano Chinese angelicas of 100 parts of nanometer Rhizoma Chuanxiongs of nanometer Gypsum Fibrosum
50 parts of 100 parts of nanometer Fructus Forsythiaes of 50 parts of nanometer Radix Scutellariaes of the nanometer Radix Paeoniae Alba
25 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Glycyrrhizae (stir-fry)
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the logical holy powder needle injection of nanometer Radix Saposhnikoviae, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
50 parts of 25 parts of nanometer Herba Menthaes of 50 parts of nanometer Herba Schizonepetaes of nanometer Radix Saposhnikoviae
50 parts in 50 parts of nanometer Natrii Sulfas of 50 parts of nano rhubarbs of nanometer Herba Ephedrae
100 parts of 300 parts of nanometer Radix Platycodoniss of 25 parts of nanometer Talcums of nanometer Fructus Gardeniae
50 parts of 50 parts of nano Chinese angelicas of 100 parts of nanometer Rhizoma Chuanxiongs of nanometer Gypsum Fibrosum
50 parts of 100 parts of nanometer Fructus Forsythiaes of 50 parts of nanometer Radix Scutellariaes of the nanometer Radix Paeoniae Alba
25 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Glycyrrhizae (stir-fry)
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the logical holy membrane of nanometer Radix Saposhnikoviae, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Fangfeng Tongsheng ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Saposhnikoviae 28-72 part nanometer Herba Schizonepetae 15-35 part nanometer Herba Menthae 28-72 part
Nanometer Herba Ephedrae 28-72 part nano rhubarb 28-72 part nanometer Natrii Sulfas 28-72 part
Nanometer Fructus Gardeniae 15-35 part nanometer Talcum 200-400 part nanometer Radix Platycodonis 60-140 part
Nanometer Gypsum Fibrosum 60-140 part nanometer Rhizoma Chuanxiong 28-72 part nano Chinese angelica 28-72 part
Nanometer Radix Paeoniae Alba 28-72 part nanometer Radix Scutellariae 60-140 part nanometer Fructus Forsythiae 28-72 part
Nanometer Radix Glycyrrhizae 120-280 part nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 15-35 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Fangfeng Tongsheng ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Saposhnikoviae 40-60 part nanometer Herba Schizonepetae 20-30 part nanometer Herba Menthae 40-60 part
Nanometer Herba Ephedrae 40-60 part nano rhubarb 40-60 part nanometer Natrii Sulfas 40-60 part
Nanometer Fructus Gardeniae 20-30 part nanometer Talcum 250-350 part nanometer Radix Platycodonis 80-120 part
Nanometer Gypsum Fibrosum 80-120 part nanometer Rhizoma Chuanxiong 40-60 part nano Chinese angelica 40-60 part
Nanometer Radix Paeoniae Alba 40-60 part nanometer Radix Scutellariae 80-120 part nanometer Fructus Forsythiae 40-60 part
Nanometer Radix Glycyrrhizae 160-240 part nanometer Rhizoma Atractylodis Macrocephalae (stir-fry) 20-30 part
3, nano medicine ' Fangfeng Tongsheng ' according to claim 1, wherein the weight proportion of each nano raw material is:
50 parts of 25 parts of nanometer Herba Menthaes of 50 parts of nanometer Herba Schizonepetaes of nanometer Radix Saposhnikoviae
50 parts in 50 parts of nanometer Natrii Sulfas of 50 parts of nano rhubarbs of nanometer Herba Ephedrae
100 parts of 300 parts of nanometer Radix Platycodoniss of 25 parts of nanometer Talcums of nanometer Fructus Gardeniae
50 parts of 50 parts of nano Chinese angelicas of 100 parts of nanometer Rhizoma Chuanxiongs of nanometer Gypsum Fibrosum
50 parts of 100 parts of nanometer Fructus Forsythiaes of 50 parts of nanometer Radix Scutellariaes of the nanometer Radix Paeoniae Alba
25 parts of 200 parts of nanometer Rhizoma Atractylodis Macrocephalaes of nanometer Radix Glycyrrhizae (stir-fry)
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Fangfeng Tongsheng 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Fangfeng Tongsheng 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects n volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100225 CN1363302A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Fangfeng Tongsheng' and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 01100225 CN1363302A (en) | 2001-01-10 | 2001-01-10 | Nano medicine 'Fangfeng Tongsheng' and its preparing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101480484B (en) * | 2008-01-11 | 2012-05-30 | 曾雄辉 | Method for preparing miraculous powder preparation of ledebouriella |
| CN102847111A (en) * | 2012-08-22 | 2013-01-02 | 李承平 | Tongli heat purging capsule |
| CN104435231A (en) * | 2014-11-05 | 2015-03-25 | 烟台天正药业有限公司 | Method for preparing medicine preparation named Fangfengtongsheng |
-
2001
- 2001-01-10 CN CN 01100225 patent/CN1363302A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101480484B (en) * | 2008-01-11 | 2012-05-30 | 曾雄辉 | Method for preparing miraculous powder preparation of ledebouriella |
| CN102847111A (en) * | 2012-08-22 | 2013-01-02 | 李承平 | Tongli heat purging capsule |
| CN104435231A (en) * | 2014-11-05 | 2015-03-25 | 烟台天正药业有限公司 | Method for preparing medicine preparation named Fangfengtongsheng |
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