CN1358495A - Film forming spraying agent - Google Patents
Film forming spraying agent Download PDFInfo
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- CN1358495A CN1358495A CN 01138340 CN01138340A CN1358495A CN 1358495 A CN1358495 A CN 1358495A CN 01138340 CN01138340 CN 01138340 CN 01138340 A CN01138340 A CN 01138340A CN 1358495 A CN1358495 A CN 1358495A
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- film forming
- film
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- spraying agent
- medicine
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Abstract
The present invention relates to a film-forming spray, containing film-forming material, disinfectant or medicine and solvent, its film-forming material contains water-soluble and alcohol-soluble two polymer materials with different properties. Before it is used, it is a solution state, in the solution the disinfectant or medicine can be added. After it is sprayed, the film can be quickly formed. Said film possesses good air permeability, can be used for making several disinfectant products, sanitary articles or medicine.
Description
Technical field
The present invention relates to the one-tenth film formulation of macromolecular material,, can be prepared into the different spray of breathability of film forming speed difference, film specifically about selecting macromolecule filming material of different nature and dose compatibility for use.
Background technology
Generally do not contain macromolecule filming material in traditional spray, can not film forming, the liquid dried of spraying out is slow, is mobile, and being difficult to be stranded in fully needs site of administration, can not bring into play maximum effect.Recently; continuous appearance along with macromolecular material; the existing film forming spraying of this type of material substance or the research report of gas-fog products of containing; the filmogen of mentioning in " a kind of compound method of film forming sterilizing agent " that Chinese patent CN1181239A is provided is a kind of water-insoluble film forming macromolecular material polyvinyl butyral resin; the film former that adopts in " manufacture method of aerosols for protective film of medicine " Hemostatic-Yantongting " " that other has Chinese patent CN1041894C to be provided equally also is non-water-soluble, film-forming macromolecular material polymethacrylic acid ethoxy ethyl ester or polyvinyl acetate, and formed film permeability is poor in the above-mentioned binomial patent.
Summary of the invention
Purpose of the present invention provides a kind of film forming speed fast for the shortcoming of the film permeability difference of the formation that solves prior art and exist, and the film of formation has the film forming spraying agent of air permeability and good.
A kind of film forming spraying agent, comprise filmogen, disinfectant or medicine, solvent, filmogen contains pure soluble macromolecular material polyvinyl butyral resin, acrylic resin or polyvinyl acetate, solvent is the different proportioning solution of ethyl acetate and/or different concentration ethanol, also contains water-soluble high-molecular material in the filmogen.
The percentage by weight of each composition of film forming spraying agent is:
Water-soluble high-molecular material 1-25%
Alcohol soluble macromolecular material 0.5-5%
Solvent 65-95%
Disinfectant or medicine 0.2-5%
Water-soluble high-molecular material is hydroxypropyl emthylcellulose or polyvidone.
Film forming spraying agent is applied to body surface and forms porous polymer material film, has air permeability and good.
The preparation method of film forming spraying agent:
Mix: it is even to get an amount of pure soluble macromolecular material and suitable quantity of water soluble macromolecular material mixing.
The vibration dissolving: it is an amount of to get solvent, puts in the hermetic container, stirs down slowly to add the mixture that previous step makes, and is enclosed in extremely all dissolvings of jolting on the shaking table.
In above-mentioned solution, add disinfectant or medicine stirring and dissolving, add solvent and make full dose become 1000ml.
Fill: quantitatively solution is poured in the spray bottle on request, airtight.
Packing.
The macromolecule filming material that has added two kinds of different solubility properties in the film forming spraying agent, it before spraying solution state, but sparge behind the body surface rapid draing and form a skim, medicine that adds in the film forming spraying agent or disinfectant etc. are prepared into the medicine that can be used for treating or kill the sterile products and the hygienic article of various microorganisms.
This spray has adhesiveness and film property, and contained pharmaceutical compositions or disinfectant composition are fixed in the film, and directly acting on and being fixed in needs site of administration, and can play long-acting treatment or bactericidal action; In addition,, after using film forming, can form the hole, have the high ventilation performance because of the eliminating or the evaporation of skin, mucosa moisture content, tissue fluid or water vapour because the film that forms not only contains pure soluble macromolecular material, but also contains water-soluble high-molecular material.
In order to prove that permeability of the present invention is better than prior art permeability, the spy has done following test:
The object of this research is three kinds of different filmogens: polyvinyl butyral resin, polyvinyl acetate, polyvinyl butyral resin+polyvidone.
The contrast experiment studies as follows: one, experimental apparatus and reagent
HG72-1 type thermostatic drying chamber, glass exsiccator, discolour silica gel
I film material is polyvinyl butyral resin+polyvidone
II film material is a polyvinyl butyral resin
III film material is polyvinyl acetate two, experimental technique
Adopt the permeability of three kinds of different filmogens of dry weight-loss method research.
Take by weighing the blank of known water content (10%), use I, II, III film material bag film-coat respectively.Get each 10 of three kinds of different coated tablet again and weigh, average, then it was put in the thermostatic drying chamber 80 ℃ of dryings 1 hour, weigh respectively again, average.Three, experimental result
| Blank heavy (g) | Peplos rear panel heavy (g) | The dry rear panel of peplos sheet heavy (g) | Dehydration percentage ratio (%) | |
| I film material | ??0.6583 | ??0.6709 | ????0.6563 | ????2.17* |
| II film material | ??0.6585 | ??0.6710 | ????0.6684 | ????0.38 |
| III film material | ??0.6581 | ??0.6704 | ????0.6695 | ????0.13 |
Annotate: * represents that relative II, III film material have significant difference.Four, conclusion
By breathability contrast experiment research, I film material has better permeability than other two kinds of film materials.
The specific embodiment
Below in conjunction with embodiment, further describe the present invention:
Polyvinyl butyral resin 20g
Polyvidone 20g
Chlorhexidine acetate 5g
Solvent adds to 1000ml
Preparing solvent: ethyl acetate and 75% ethanol are to mix at 1: 8 by volume.
Preparation method:
Mix: get polyvinyl butyral resin 20g, polyvidone 20g mix homogeneously.
The vibration dissolving: the solvent of getting preparation is an amount of, puts in the hermetic container, stirs down slowly to add polyvinyl butyral resin and povidone mixture, is enclosed in extremely all dissolvings of jolting on the shaking table.
Add chlorhexidine acetate 5g stirring and dissolving in above-mentioned solution, the solvent that adds preparation makes full dose become 1000ml.
Fill: quantitatively solution is poured in the spray bottle on request, airtight.
Packing.
Claims (5)
1, a kind of film forming spraying agent, comprise filmogen, disinfectant or medicine, solvent, filmogen contains pure soluble macromolecular material polyvinyl butyral resin, acrylic resin or polyvinyl acetate, solvent is the different proportioning solution of ethyl acetate and/or different concentration ethanol, it is characterized in that also containing in the filmogen water-soluble high-molecular material.
2, film forming spraying agent according to claim 1 is characterized in that the percentage by weight of each composition is:
Water-soluble high-molecular material 1-25%
Alcohol soluble macromolecular material 0.5-5%
Solvent 65-95%
Disinfectant or medicine 0.2-5%
3, film forming spraying agent according to claim 2 is characterized in that water-soluble high-molecular material is hydroxypropyl emthylcellulose or polyvidone.
4, film forming spraying agent according to claim 3 is characterized in that:
Polyvinyl butyral resin 20g
Polyvidone 20g
Chlorhexidine acetate (or other medicines) 5g
Solvent adds to 1000ml
Preparing solvent: ethyl acetate and 75% ethanol are to mix at 1: 8 by volume.
5, according to the described film forming spraying agent of one of claim 1-4, it is characterized in that spray is applied to body surface and forms porous polymer material film, have air permeability and good.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01138340 CN1358495A (en) | 2001-12-21 | 2001-12-21 | Film forming spraying agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01138340 CN1358495A (en) | 2001-12-21 | 2001-12-21 | Film forming spraying agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1358495A true CN1358495A (en) | 2002-07-17 |
Family
ID=4674544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01138340 Pending CN1358495A (en) | 2001-12-21 | 2001-12-21 | Film forming spraying agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1358495A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101927004A (en) * | 2010-08-25 | 2010-12-29 | 邱日辉 | Macromolecule slow controlled release long-acting sterilizing product and preparation method thereof |
| CN107115326A (en) * | 2010-04-13 | 2017-09-01 | 雷尔玛达治疗股份有限公司 | The dennophannaceutical compositions and its application method of 1 methyl N (2,6 xylyl) 2 piperidine formamides |
| CN107362271A (en) * | 2017-08-03 | 2017-11-21 | 华子昂 | A kind of Chinese medicine composition for treating breathing problem and preparation method thereof |
| CN112107567A (en) * | 2020-02-16 | 2020-12-22 | 江苏科兴诺生物技术有限公司 | Multi-purpose spraying film-forming disinfectant and preparation method thereof |
| CN113289055A (en) * | 2021-05-25 | 2021-08-24 | 振德医疗用品股份有限公司 | Green liquid adhesive bandage with antibacterial function and preparation method thereof |
| CN113712028A (en) * | 2020-10-21 | 2021-11-30 | 南京百思福医药科技有限公司 | Photoluminescent long-acting film-forming disinfection composition and preparation method and application thereof |
-
2001
- 2001-12-21 CN CN 01138340 patent/CN1358495A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107115326A (en) * | 2010-04-13 | 2017-09-01 | 雷尔玛达治疗股份有限公司 | The dennophannaceutical compositions and its application method of 1 methyl N (2,6 xylyl) 2 piperidine formamides |
| CN107115326B (en) * | 2010-04-13 | 2021-01-22 | 雷尔玛达治疗股份有限公司 | Skin pharmaceutical composition of 1-methyl-N- (2, 6-xylyl) -2-piperidine formamide and using method thereof |
| US11607407B2 (en) | 2010-04-13 | 2023-03-21 | Relmada Therapeutics, Inc. | Dermal pharmaceutical compositions of 1-methyl-2′,6′-pipecoloxylidide and method of use |
| CN101927004A (en) * | 2010-08-25 | 2010-12-29 | 邱日辉 | Macromolecule slow controlled release long-acting sterilizing product and preparation method thereof |
| CN107362271A (en) * | 2017-08-03 | 2017-11-21 | 华子昂 | A kind of Chinese medicine composition for treating breathing problem and preparation method thereof |
| CN112107567A (en) * | 2020-02-16 | 2020-12-22 | 江苏科兴诺生物技术有限公司 | Multi-purpose spraying film-forming disinfectant and preparation method thereof |
| CN113712028A (en) * | 2020-10-21 | 2021-11-30 | 南京百思福医药科技有限公司 | Photoluminescent long-acting film-forming disinfection composition and preparation method and application thereof |
| CN113289055A (en) * | 2021-05-25 | 2021-08-24 | 振德医疗用品股份有限公司 | Green liquid adhesive bandage with antibacterial function and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |