CN1351012A - Process for extracting high-purity tea polyphenol, theapigment and theine - Google Patents
Process for extracting high-purity tea polyphenol, theapigment and theine Download PDFInfo
- Publication number
- CN1351012A CN1351012A CN 00120528 CN00120528A CN1351012A CN 1351012 A CN1351012 A CN 1351012A CN 00120528 CN00120528 CN 00120528 CN 00120528 A CN00120528 A CN 00120528A CN 1351012 A CN1351012 A CN 1351012A
- Authority
- CN
- China
- Prior art keywords
- tea
- water
- polyphenol
- weight
- obtains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 241001122767 Theaceae Species 0.000 title claims abstract 25
- 238000000034 method Methods 0.000 title abstract description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 title abstract description 4
- 235000013824 polyphenols Nutrition 0.000 title abstract description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 31
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims abstract description 27
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 239000001054 red pigment Substances 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 11
- 239000012074 organic phase Substances 0.000 claims abstract description 11
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 238000005406 washing Methods 0.000 claims abstract description 6
- LCCDINSFSOALJK-UHFFFAOYSA-N 1,3,4-trimethylpurine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2(C)N=CN=C21 LCCDINSFSOALJK-UHFFFAOYSA-N 0.000 claims description 22
- 238000001556 precipitation Methods 0.000 claims description 17
- 239000000049 pigment Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 13
- 238000005516 engineering process Methods 0.000 claims description 11
- 238000007654 immersion Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 238000001471 micro-filtration Methods 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 239000000428 dust Substances 0.000 claims description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 108010059820 Polygalacturonase Proteins 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 claims description 2
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 claims description 2
- 239000012043 crude product Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000007670 refining Methods 0.000 claims description 2
- 239000002893 slag Substances 0.000 claims description 2
- IPMYMEWFZKHGAX-ZKSIBHASSA-N theaflavin Chemical compound C1=C2C([C@H]3OC4=CC(O)=CC(O)=C4C[C@H]3O)=CC(O)=C(O)C2=C(O)C(=O)C=C1[C@@H]1[C@H](O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-ZKSIBHASSA-N 0.000 claims description 2
- 229940026509 theaflavin Drugs 0.000 claims description 2
- 235000014620 theaflavin Nutrition 0.000 claims description 2
- FNCFOGDPWJIFKP-UHFFFAOYSA-K [Cl-].[Ca+2].S(=O)(=O)([O-])[O-].[Zn+2] Chemical compound [Cl-].[Ca+2].S(=O)(=O)([O-])[O-].[Zn+2] FNCFOGDPWJIFKP-UHFFFAOYSA-K 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 244000269722 Thea sinensis Species 0.000 description 47
- 235000013616 tea Nutrition 0.000 description 46
- 235000019439 ethyl acetate Nutrition 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000003672 processing method Methods 0.000 description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 2
- -1 acid solution adding Chemical class 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229960001948 caffeine Drugs 0.000 description 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00120528 CN1112110C (en) | 2000-10-29 | 2000-10-29 | Process for extracting high-purity tea polyphenol, theapigment and theine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 00120528 CN1112110C (en) | 2000-10-29 | 2000-10-29 | Process for extracting high-purity tea polyphenol, theapigment and theine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1351012A true CN1351012A (en) | 2002-05-29 |
CN1112110C CN1112110C (en) | 2003-06-25 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 00120528 Expired - Fee Related CN1112110C (en) | 2000-10-29 | 2000-10-29 | Process for extracting high-purity tea polyphenol, theapigment and theine |
Country Status (1)
Country | Link |
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CN (1) | CN1112110C (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1304586C (en) * | 2003-12-13 | 2007-03-14 | 无锡市世纪生物药业有限公司 | Method for preparing tea pigment |
CN1317966C (en) * | 2004-07-19 | 2007-05-30 | 陈忠 | Tea essence for tea food and its preparation method |
CN100374027C (en) * | 2004-03-24 | 2008-03-12 | 上海市农业科学院作物育种栽培研究所 | Extraction process of plant mildew-proof preservative |
CN101142957B (en) * | 2007-10-09 | 2010-09-15 | 浙江大学 | Method for extracting green tea concentrated liquid |
CN101575326B (en) * | 2009-06-25 | 2011-05-04 | 合肥工业大学 | Method for extracting tea polyphenol from glede tea |
CN101508690B (en) * | 2009-03-17 | 2011-05-11 | 林峰 | Novel methods for simultaneously extracting tea polyphenol, tea polysaccharide and caffeinum from tea |
CN103012403A (en) * | 2013-01-05 | 2013-04-03 | 四川中测科技投资有限公司 | Tea leaf comprehensive utilizing and deep processing method |
CN104306559A (en) * | 2014-10-14 | 2015-01-28 | 王惠莹 | Preparation method of golden camellia leaf pigment |
CN104846029A (en) * | 2015-04-22 | 2015-08-19 | 湖南农业大学 | Preparation method of simple theaflavin monomer |
CN106070840A (en) * | 2016-06-16 | 2016-11-09 | 浙江大学 | Preparation has the method for the water alcohol compatibility Folium Camelliae sinensis extract of tea scented tea color |
CN106728417A (en) * | 2017-01-18 | 2017-05-31 | 俞镜含 | A kind of gentle method for extracting Tea Pigment |
CN111035697A (en) * | 2019-12-31 | 2020-04-21 | 格律药业有限公司 | Pharmaceutical composition and application thereof, preparation method of nanoparticles, extraction process of tea extract and tea extract |
CN111035696A (en) * | 2019-12-16 | 2020-04-21 | 格律药业有限公司 | Pharmaceutical composition containing tea extract and its use for treating cancer |
-
2000
- 2000-10-29 CN CN 00120528 patent/CN1112110C/en not_active Expired - Fee Related
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1304586C (en) * | 2003-12-13 | 2007-03-14 | 无锡市世纪生物药业有限公司 | Method for preparing tea pigment |
CN100374027C (en) * | 2004-03-24 | 2008-03-12 | 上海市农业科学院作物育种栽培研究所 | Extraction process of plant mildew-proof preservative |
CN1317966C (en) * | 2004-07-19 | 2007-05-30 | 陈忠 | Tea essence for tea food and its preparation method |
CN101142957B (en) * | 2007-10-09 | 2010-09-15 | 浙江大学 | Method for extracting green tea concentrated liquid |
CN101508690B (en) * | 2009-03-17 | 2011-05-11 | 林峰 | Novel methods for simultaneously extracting tea polyphenol, tea polysaccharide and caffeinum from tea |
CN101575326B (en) * | 2009-06-25 | 2011-05-04 | 合肥工业大学 | Method for extracting tea polyphenol from glede tea |
CN103012403A (en) * | 2013-01-05 | 2013-04-03 | 四川中测科技投资有限公司 | Tea leaf comprehensive utilizing and deep processing method |
CN103012403B (en) * | 2013-01-05 | 2015-03-11 | 四川中测科技投资有限公司 | Tea leaf comprehensive utilizing and deep processing method |
CN104306559A (en) * | 2014-10-14 | 2015-01-28 | 王惠莹 | Preparation method of golden camellia leaf pigment |
CN104846029A (en) * | 2015-04-22 | 2015-08-19 | 湖南农业大学 | Preparation method of simple theaflavin monomer |
CN104846029B (en) * | 2015-04-22 | 2017-12-29 | 湖南农业大学 | A kind of preparation method of simple kinds of theaflavin monomer |
CN106070840A (en) * | 2016-06-16 | 2016-11-09 | 浙江大学 | Preparation has the method for the water alcohol compatibility Folium Camelliae sinensis extract of tea scented tea color |
CN106728417A (en) * | 2017-01-18 | 2017-05-31 | 俞镜含 | A kind of gentle method for extracting Tea Pigment |
CN111035696A (en) * | 2019-12-16 | 2020-04-21 | 格律药业有限公司 | Pharmaceutical composition containing tea extract and its use for treating cancer |
CN111035697A (en) * | 2019-12-31 | 2020-04-21 | 格律药业有限公司 | Pharmaceutical composition and application thereof, preparation method of nanoparticles, extraction process of tea extract and tea extract |
Also Published As
Publication number | Publication date |
---|---|
CN1112110C (en) | 2003-06-25 |
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Legal Events
Date | Code | Title | Description |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: SHANXI DONGMA BIOLOGY MEDICINE SCIENCE CO., LTD. Free format text: FORMER OWNER: LIU ZHIJIONG Effective date: 20080418 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20080418 Address after: New development zone of East Development Zone, Huairen County, Shuozhou, Shanxi Patentee after: Shanxi East horse biological medicine Polytron Technologies Inc Address before: Shapingba Chongqing teachers training school Patentee before: Liu Zhijiong |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20030625 Termination date: 20131029 |