CN1338254A - Hydroxymethionine salt as trace element additive and its preparing process - Google Patents
Hydroxymethionine salt as trace element additive and its preparing process Download PDFInfo
- Publication number
- CN1338254A CN1338254A CN00113616A CN00113616A CN1338254A CN 1338254 A CN1338254 A CN 1338254A CN 00113616 A CN00113616 A CN 00113616A CN 00113616 A CN00113616 A CN 00113616A CN 1338254 A CN1338254 A CN 1338254A
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- hydroxy methionine
- trace mineral
- mineral supplement
- methionine
- hydroxy
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A hydroxymethionine salt (C5H8O3M) as the additive of trace elements for providing trace elements and methionine to human or animals is prepared through chelating reaction of liquid hydroxymethionine on the aqueous solution of inorganic metallic salt in mole ratio of 1:(1-2) at 500-100 deg.C and 6-8 of pH value for 0.8-1.2 hr.
Description
The present invention relates to a kind of trace mineral supplement and preparation method thereof.
Current mankind and animal trace element supplement zinc, ferrum, manganese, cobalt, magnesium, selenium, chromium, copper etc. mostly adopt its inorganic salt form, and absorbing must be by the various biological barrier, and its absorbance is low, and addition is big, and biological value is low; And these inorganic salts have destruction to vitamin isoreactivity material.
The object of the present invention is to provide a kind of absorption rate height, addition is little, the biological value height; Except that satisfying the nutrition of animal and human body, can also provide a kind of trace mineral supplement and preparation method thereof of the nutrition of methionine to trace element.
The object of the present invention is achieved like this: trace mineral supplement of the present invention is hydroxy methionine salt chelate (C
5H
8O
3M).
Its preparation method is as follows:
1, the inorganic salt solution of liquid hydroxy methionine and slaine is 1: 1～2 with mol ratio, and 50～100 ℃ of temperature, in the presence of sodium hydroxide, control pH value 6～8 reacted under the condition of normal pressure 0.8～1.2 hour, generated hydroxy methionine salt chelate; Its reaction equation is as follows:
+ NaSO
4+ 2H
2O
2, centrifugalize, washing;
3, dry, pulverize, be packaged into finished product.
Because this chelating salt is to absorb by the aminoacid approach in digestive tract, speed is fast, absorbance improves greatly, the biological value height, can reduce the consumption of additive; The micro-element nutrition of improving humans and animals had good facilitation; Except that the nutrition of the trace element that satisfies people and animal, also can provide the nutrition of methionine, so can promote growth; Can also avoid the destruction of inorganic salt to vitamin isoreactivity material; Can significantly improve the utilization rate of feedstuff.This hydroxy methionine chelate has stable chemical constitution, safety non-toxic, nonirritant.This additive can be widely used in various animals: as pig, fowl, aquatic animal etc., also can be applicable to the people.
Embodiment 1: methionine hydroxy zinc (C
5H
8O
3Zn) preparation and application:
85kg hydroxy methionine+80.5kg zinc sulfate monohydrate+41Kg98% technical pure sodium hydroxide is under 80 ℃ reaction temperature, regulating PH is 6.5, reacts 1 hour, obtains 128 kilograms of methionine hydroxy zincs, wherein zinc content is 21.5%, hydroxy methionine content 52.6%.Centrifugalize, washing; Dry, pulverize, be finished product.Feed breeding boar with this additive 200～400 gram/tons, can promote growth, disease resistance enhancemen; Prolong boar and breed service life; Feed suckling piglet with this additive 200～400 gram/tons, can help improving hemopoietic function and immune function, improve anti-stress ability and immunity, promote growth, significantly improve the economic worth of feedstuff.The barren sow of engrossing then can promote growth, improves feedstuff-meat ratio, improves yellowish pink, makes the Corii Sus domestica skin ruddy, the hair color light.Feed poultry the speed of growth is improved, feedstuff-meat ratio descends, and strengthens the feather glossiness, improves its stress ability, reduces mortality rate.Feed aquatic animal, but enhancing immunity reduces incidence and mortality, promotes growth, reduce disease and take place, improve efficiency of feed utilization.
Embodiment 2: hydroxy methionine iron (C
5H
8O
3Fe) preparation and application:
85kg hydroxy methionine+85kg ferrous sulfate monohydrate+41kg98% technical pure sodium hydroxide is under 80 ℃ reaction temperature, and regulating PH is 6.5, reacts 1 hour, obtains 115 kilograms of hydroxy methionine irons, centrifugalize, washing; Dry, pulverize, be finished product.Wherein iron content is 21.3%, hydroxy methionine content 52.4%.Feed breeding boar with this additive 300～500 gram/tons, can promote growth, disease resistance enhancemen; Prolong boar and breed service life; Feed sow with this additive, can significantly improve the interior ferrum deposit of piglet body in the tire, improve nascent body weight of piglet and survival rate; Concentration of iron improves in the milk; Feed piglet and can effectively prevent piglet anaemia, mortality rate reduces, and significantly improves the piglet hemoglobin level, improves the immune disease-resistance ability and promotes growth.The barren sow of engrossing then promotes growth, improves feedstuff-meat ratio, improves yellowish pink, makes the Corii Sus domestica skin ruddy, the hair color light.Feed poultry and help feedstuff-egg ratio, improve the hatching of breeding eggs rate, improve anti-stress ability, reduce mortality rate.Feed aquatic animal and can promote growth, improve survival rate, increase ferrum and absorb.
Embodiment 3: hydroxy methionine copper: 341 kilograms of hydroxy methionine+250 kilogram copper sulphate pentahydrate+82 kilogram of 98% technical grade sodium hydroxide are under the reaction temperature of 80 ℃ of maintenances, control PH is 68 reactions 1 hour, obtain 370 kilograms of hydroxy methionine copper, wherein copper content is 16.3%, and hydroxy methionine content is 73.1%.
Embodiment 4: hydroxy methionine manganese: 85 kilograms of hydroxy methionine+75.5 kilogram manganese sulfate monohydrate+41 kilogram of 98% technical grade sodium hydroxide control PH are 6.8, keeping reaction temperature is 80 ℃, obtain 113 kilograms in hydroxy methionine manganese, wherein manganese content is 21.7%, hydroxy methionine content 52.8%.
Claims (10)
1, a kind of trace mineral supplement is characterized in that being hydroxy methionine salt chelate (C
5H
8O
3M).
2, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is a hydroxy methionine iron.
3, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is a methionine hydroxy zinc.
4, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is a hydroxy methionine copper.
5, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is a hydroxy methionine manganese.
6, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is a hydroxy methionine chromium.
7, trace mineral supplement according to claim 1, the described hydroxy methionine salt of its feature chelate is a hydroxy methionine magnesium.
8, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is a hydroxy methionine selenium.
9, trace mineral supplement according to claim 1 is characterized in that described hydroxy methionine salt chelate is the hydroxy methionine cobalt.
10, a kind of preparation method of trace mineral supplement as claimed in claim 1 is characterized in that may further comprise the steps:
(1), liquid hydroxy methionine and metal inorganic saline solution be 1: 1～2 with mol ratio, 50～100 ℃ of temperature, in the presence of sodium hydroxide, control pH value 6～8 reacted under the condition of normal pressure 0.8～1.2 hour, obtained hydroxy methionine salt;
(2), centrifugalize, washing;
(3), dry, pulverize, be packaged into finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00113616A CN1338254A (en) | 2000-08-16 | 2000-08-16 | Hydroxymethionine salt as trace element additive and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00113616A CN1338254A (en) | 2000-08-16 | 2000-08-16 | Hydroxymethionine salt as trace element additive and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1338254A true CN1338254A (en) | 2002-03-06 |
Family
ID=4583383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00113616A Pending CN1338254A (en) | 2000-08-16 | 2000-08-16 | Hydroxymethionine salt as trace element additive and its preparing process |
Country Status (1)
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|---|---|
| CN (1) | CN1338254A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004096205A1 (en) * | 2003-04-30 | 2004-11-11 | Yiqiang Huang | A process for producing an additive comprising a salt obtained from hydroxy methionine and a trace element |
| CN101843295A (en) * | 2010-04-09 | 2010-09-29 | 广东海洋大学 | Mineral element additive for Babylonia |
| CN101971916A (en) * | 2010-08-14 | 2011-02-16 | 格特生物制药（天津）有限公司 | Liquid compound premixed feed containing mineral substances and amino acid |
| CN101704774B (en) * | 2009-10-30 | 2013-11-20 | 长沙兴加生物技术有限公司 | Hydroxyl nickel methionine and preparation method and application thereof |
| CN103641754A (en) * | 2013-11-19 | 2014-03-19 | 重庆紫光化工股份有限公司 | Preparation method of medicinal D,L-2-hydroxy-4-methylthiobutyric acid metal chelate |
| CN104171545A (en) * | 2014-07-08 | 2014-12-03 | 北京挑战牧业科技股份有限公司 | Low-copper and antibiotic-free composite premix for pigs |
| CN114524756A (en) * | 2022-04-11 | 2022-05-24 | 昕嘉生物技术(长沙)有限公司 | Magnesium hydroxymethionine and preparation method thereof |
| WO2023024222A1 (en) * | 2021-08-25 | 2023-03-02 | 湖南德邦生物科技有限公司 | Synthesis method for manganese hydroxymethionine |
-
2000
- 2000-08-16 CN CN00113616A patent/CN1338254A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004096205A1 (en) * | 2003-04-30 | 2004-11-11 | Yiqiang Huang | A process for producing an additive comprising a salt obtained from hydroxy methionine and a trace element |
| CN101704774B (en) * | 2009-10-30 | 2013-11-20 | 长沙兴加生物技术有限公司 | Hydroxyl nickel methionine and preparation method and application thereof |
| CN101843295A (en) * | 2010-04-09 | 2010-09-29 | 广东海洋大学 | Mineral element additive for Babylonia |
| CN101971916A (en) * | 2010-08-14 | 2011-02-16 | 格特生物制药（天津）有限公司 | Liquid compound premixed feed containing mineral substances and amino acid |
| CN101971916B (en) * | 2010-08-14 | 2013-04-03 | 格特生物制药（天津）有限公司 | Liquid compound premixed feed containing mineral substances and amino acid |
| CN103641754A (en) * | 2013-11-19 | 2014-03-19 | 重庆紫光化工股份有限公司 | Preparation method of medicinal D,L-2-hydroxy-4-methylthiobutyric acid metal chelate |
| CN103641754B (en) * | 2013-11-19 | 2016-08-24 | 宁夏紫光天化蛋氨酸有限责任公司 | The preparation method of medicinal D, L-2-hydroxy-4-methylthiobutyric acid metallo-chelate |
| CN104171545A (en) * | 2014-07-08 | 2014-12-03 | 北京挑战牧业科技股份有限公司 | Low-copper and antibiotic-free composite premix for pigs |
| WO2023024222A1 (en) * | 2021-08-25 | 2023-03-02 | 湖南德邦生物科技有限公司 | Synthesis method for manganese hydroxymethionine |
| CN114524756A (en) * | 2022-04-11 | 2022-05-24 | 昕嘉生物技术(长沙)有限公司 | Magnesium hydroxymethionine and preparation method thereof |
| CN114524756B (en) * | 2022-04-11 | 2023-08-15 | 昕嘉生物技术(长沙)有限公司 | Hydroxy magnesium methionine and preparation method thereof |
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