CN1335772A - 阿扑***在制备治疗男性器质性***障碍的药物中的应用 - Google Patents
阿扑***在制备治疗男性器质性***障碍的药物中的应用 Download PDFInfo
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- CN1335772A CN1335772A CN99814559A CN99814559A CN1335772A CN 1335772 A CN1335772 A CN 1335772A CN 99814559 A CN99814559 A CN 99814559A CN 99814559 A CN99814559 A CN 99814559A CN 1335772 A CN1335772 A CN 1335772A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/213,567 US6291471B1 (en) | 1998-12-17 | 1998-12-17 | Use of apomorphine for the treatment of organic erectile dysfunction in males |
| US09/213,567 | 1998-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1335772A true CN1335772A (zh) | 2002-02-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99814559A Pending CN1335772A (zh) | 1998-12-17 | 1999-12-13 | 阿扑***在制备治疗男性器质性***障碍的药物中的应用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6291471B1 (tr) |
| EP (1) | EP1140094A1 (tr) |
| JP (1) | JP2003521462A (tr) |
| KR (1) | KR20010101241A (tr) |
| CN (1) | CN1335772A (tr) |
| AR (1) | AR021912A1 (tr) |
| AU (1) | AU2175800A (tr) |
| BG (1) | BG105664A (tr) |
| BR (1) | BR9916114A (tr) |
| CA (1) | CA2354601A1 (tr) |
| CZ (1) | CZ20012084A3 (tr) |
| HK (1) | HK1043303A1 (tr) |
| HU (1) | HUP0201618A3 (tr) |
| IL (1) | IL143410A0 (tr) |
| NO (1) | NO20012985L (tr) |
| NZ (1) | NZ511790A (tr) |
| PL (1) | PL354920A1 (tr) |
| SK (1) | SK8262001A3 (tr) |
| TR (1) | TR200101719T2 (tr) |
| TW (1) | TW577740B (tr) |
| WO (1) | WO2000035457A1 (tr) |
| ZA (1) | ZA200104146B (tr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112955967A (zh) * | 2018-06-14 | 2021-06-11 | 阿斯利康(英国)有限公司 | 用cgmp特异性磷酸二酯酶5抑制剂医药组合物治疗***功能障碍的方法 |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566368B2 (en) * | 1994-04-22 | 2003-05-20 | Pentech Pharmaceuticals, Inc. | Apomorphine-containing dosage form for ameliorating male erectile dysfunction |
| BR0005797A (pt) * | 2000-03-20 | 2001-10-16 | Abbott Lab | Métodos para o tratamento de disfunção sexual com apomorfina em nìveis de concentração plasmática especificados |
| WO2002041894A2 (en) * | 2000-11-22 | 2002-05-30 | Abbott Laboratories | Selective dopamine d4 receptor agonists for treating sexual dysfunction |
| BR0207024A (pt) * | 2001-02-08 | 2004-02-25 | Pharmacia Corp Global Patent D | Medicamento com ação inicial rápida para o tratamento de disfunção sexual |
| BR0308567A (pt) * | 2002-03-19 | 2007-01-09 | Michael Holick | derivados de glicosìdeo e glicosìdeo de ortoéster de apomorfina, análogos, e seus usos |
| SE0202365D0 (sv) | 2002-08-05 | 2002-08-05 | Pharmacia Ab | New formulation and use thereof |
| BRPI0409380A (pt) * | 2003-04-14 | 2006-04-18 | Vectura Ltd | composições farmacêuticas |
| US20040204439A1 (en) * | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
| JP2007532670A (ja) * | 2004-04-13 | 2007-11-15 | ザ マクレーン ホスピタル コーポレーション | Ｒ（−）−１１−ヒドロキシアポルフィン誘導体およびその使用方法 |
| GB2437488A (en) * | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
| WO2009009083A1 (en) * | 2007-07-12 | 2009-01-15 | The Mclean Hospital Corporation | R(-)-2-methoxy-11-hydroxyaporphine and derivatives thereof |
| BRPI0800596A2 (pt) | 2008-01-31 | 2009-09-22 | Univ Minas Gerais | método para a potencialização da função erétil através do uso das composições farmacêuticas de toxina tx2-6 da aranha phoneutria nigriventer |
| KR101890317B1 (ko) | 2010-12-16 | 2018-08-22 | 선오비온 파마슈티컬스 인코포레이티드 | 설하 필름 |
| KR101374500B1 (ko) * | 2012-10-09 | 2014-03-13 | 울산대학교 산학협력단 | Ｒ(-)-프로필노르아포모르핀을 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물 |
| ES2702174T3 (es) | 2013-04-05 | 2019-02-27 | Boehringer Ingelheim Int | Usos terapéuticos de empagliflozina |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| WO2014170383A1 (en) | 2013-04-18 | 2014-10-23 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| JP6561136B2 (ja) * | 2015-04-30 | 2019-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ***機能不全を治療又は改善するための方法及びｓｇｌｔ２阻害薬を含む医薬組成物 |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256652A (en) | 1987-11-12 | 1993-10-26 | Pharmedic Co. | Topical compositions and methods for treatment of male impotence |
| US5270323A (en) | 1990-05-31 | 1993-12-14 | Pfizer Inc. | Method of treating impotence |
| US5292520A (en) | 1990-09-13 | 1994-03-08 | Akzo N.V. | Stabilized solid pharmaceutical composition containing acid addition salts of a basic drug and an alkaline stabilizer |
| ATE290864T1 (de) | 1993-03-26 | 2005-04-15 | Franciscus Wilhelmus He Merkus | Pharmazeutische zusammensetzungen zur intranasalen verabreichung von dihydroergotamin |
| EP0758895B1 (en) * | 1994-04-22 | 2000-01-26 | Pentech Pharmaceuticals, Inc. | Sublingual dosage forms containing apomorphine for use in the treatment of erectile dysfunction |
| US5562917A (en) | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| US5888534A (en) | 1995-06-13 | 1999-03-30 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| US5624677A (en) * | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| US5688499A (en) | 1996-03-13 | 1997-11-18 | Queen's University At Kingston | Antagonism of endothelin actions |
| DE19652268C2 (de) | 1996-12-16 | 2000-06-29 | Lohmann Therapie Syst Lts | Arzneizubereitung für die Freisetzung von Apomorphin in der Mundhöhle |
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- 1999-12-13 CN CN99814559A patent/CN1335772A/zh active Pending
- 1999-12-13 JP JP2000587777A patent/JP2003521462A/ja not_active Withdrawn
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- 1999-12-13 CZ CZ20012084A patent/CZ20012084A3/cs unknown
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- 1999-12-13 CA CA002354601A patent/CA2354601A1/en not_active Abandoned
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- 1999-12-13 TR TR2001/01719T patent/TR200101719T2/tr unknown
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2001
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- 2001-07-03 BG BG105664A patent/BG105664A/xx unknown
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2002
- 2002-03-28 HK HK02102415.1A patent/HK1043303A1/zh unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112955967A (zh) * | 2018-06-14 | 2021-06-11 | 阿斯利康(英国)有限公司 | 用cgmp特异性磷酸二酯酶5抑制剂医药组合物治疗***功能障碍的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20012985L (no) | 2001-08-16 |
| CZ20012084A3 (cs) | 2002-01-16 |
| WO2000035457A1 (en) | 2000-06-22 |
| HUP0201618A3 (en) | 2003-03-28 |
| TR200101719T2 (tr) | 2002-08-21 |
| US6291471B1 (en) | 2001-09-18 |
| CA2354601A1 (en) | 2000-06-22 |
| EP1140094A1 (en) | 2001-10-10 |
| KR20010101241A (ko) | 2001-11-14 |
| PL354920A1 (en) | 2004-03-22 |
| BR9916114A (pt) | 2003-01-14 |
| BG105664A (en) | 2002-02-28 |
| AR021912A1 (es) | 2002-09-04 |
| NO20012985D0 (no) | 2001-06-15 |
| JP2003521462A (ja) | 2003-07-15 |
| TW577740B (en) | 2004-03-01 |
| SK8262001A3 (en) | 2002-01-07 |
| HUP0201618A2 (en) | 2002-09-28 |
| HK1043303A1 (zh) | 2002-09-13 |
| ZA200104146B (en) | 2002-08-21 |
| AU2175800A (en) | 2000-07-03 |
| IL143410A0 (en) | 2002-04-21 |
| NZ511790A (en) | 2004-04-30 |
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