CN1315509C - Medicine for curing pyogenic osteomyelitis and process for preparing the same - Google Patents

Medicine for curing pyogenic osteomyelitis and process for preparing the same Download PDF

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CN1315509C
CN1315509C CNB200510085598XA CN200510085598A CN1315509C CN 1315509 C CN1315509 C CN 1315509C CN B200510085598X A CNB200510085598X A CN B200510085598XA CN 200510085598 A CN200510085598 A CN 200510085598A CN 1315509 C CN1315509 C CN 1315509C
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corii asini
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CN1733184A (en
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藏照书
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Abstract

The present invention discloses a medicine for treating pyogenic osteomyelitis, which is prepared from the following raw materials according to the proportion by weight: 20 to 40 portions of milkvetch root, 10 to 30 portions of angelica, 20 to 40 portions of sea horse, 8 to 15 portions of dragon blood, 8 to 15 portions of cutch, 10 to 30 portions of prepared frankincense, 10 to 30 portions of prepared myrrh, 10 to 30 portions of donkey-hide gelatin, 10 to 30 portions of rhizoma drynariae, 10 to 30 portions of deglued antler and 10 to 30 portions of spina gleditsiae. The present invention also discloses a preparation method of the medicine. The medicine can be a capsule, and has the functions of converging sore openings, accelerating the growth of bones, promoting porosis and accelerating the healing of sinus tracts after being taken.

Description

A kind of medicine for the treatment of suppurative osteomyelitis and preparation method thereof
Affiliated technical field
What the present invention relates to is a kind of medicine for the treatment of suppurative osteomyelitis, is the Chinese patent medicine of feedstock production with Chinese medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Suppurative osteomyelitis has acute and chronic branch, is the inflammatory purulent disease that bone and surrounding tissue take place.Fail thoroughly control as acute stage, outbreak can develop into chronic pertinacious disease repeatedly, does not prolongedly heal.Also having hypotoxicity to infect, show as chronicly when morbidity, is the chronic infection of bone.This sick etiology and pathogenesis is, because the stimulation of abscess, the new bone of subperiosteum bone formation one deck forms the irregular bony shell of thickness again gradually, in have one or several sinus tracts to communicate with bone cavity.Simultaneously, key inner tissue is obstructed the interior blood supply of bone also because of blood supply insufficiency forms thrombosis, forms sequestrum.The fritter sequestrum can be absorbed or discharge through sinus tract, and the bulk sequestrum then stays in interior, makes the sinus tract can not be closed.So show the sinus tract mouth clinically granulation tissue is arranged, pus is dripping, and that the part has is red, swollen, hot, the sense of pain, even skeleton deformity occurs.These sick great majority are infection of staphylococcus aureus, and the gram positive bacterial infection person has the trend of increasing in recent years.After sinus tract formed, most cases showed as mixed infection, so insensitive or invalid situation can appear in the antibiotic conventional therapy, made that sufferer is prolonged not to heal, or the time send out when healing, sustainable several years, become obstinate disease.
Suppurative osteomyelitis, the scope of genus motherland's medical science " attached bone carbuncle ", " pasting the bone carbuncle ", " pyogenic infection of the bone " has detailed record and a large amount of argumentations in the traditional Chinese medical science ancient books.It classifies one " times " as " all source of disease marquis opinion " special secondary school door knobs of Sui's Chao Yuanfang (550-630 A.D.), says: " attached bone carbuncle is also contained by body and is got cold when wind, air-cooledly goes into muscle; fight with hot phase, the nearly bone of volt knot becomes carbuncle, and its shape is without a head; but swell and ache and wealthy, it is damp that its skin approaches, and the attached bone carbuncle of meaning is also ".Tang's Sun Simiao claims in Thousand Golden Prescriptions: " broken with its nothing, attached bone becomes pus, so the name pyogenic infection of the bone ".Dou Han minister in ancient times Song also had monograph in " skin infection experience pandect ", say: " husband pastes bone carbuncle person, and promptly attached bone carbuncle also.All attached bone pastes meat and gives birth to, though the different disease then of word.Sending out of this disease, the dog days fever of the body, harmful wind is gone into joint, fights mutually with heat, meets cold wetly again, or exhaustion due to sexual indulgence is too, two foot water, or lying on bed for a long time wetland, physical weakness and be subjected to the cold-evil, right wind heat volt knot is stopped up and is held back attached bone and form ".
At present, clinical early treatment to chronic suppurative osteomyelisis, in, doctor trained in Western medicine all tends in advance based on the method for Drug therapy, doctor trained in Western medicine is taked a large amount of antibiotic therapies, then goes operative treatment when invalid, adopts methods such as surgical incision, washout, drainage with medicated thread.Though said method has definite curative effect to chronic suppurative osteomyelisis, its treatment phase is longer, makes the patient suffer ailing the torment for a long time, and late result is also not good enough, have disable or sinus tract mouth surrounding skin generation canceration may and regret all one's life.
The tradition Chinese medicine then press the treatment of acute attack stage and chronic period two-phase, imposes heat-clearing and toxic substances removing, benefiting qi and removing blood stasis, removing dampness and battalion, expelling pathogens by strengthening vital qi and expelling pus respectively, sets upright poison holding, holds back mouthful granulation promoting etc. and be the main rule of treatment, and it is auxiliary that the traditional operative therapy of employing is also arranged.Though curative effect is reliable, also there is dialectical complexity, a weakness such as the inconvenience of taking medicine, except that section hospital, specialist, general hospital and general doctor are difficult for grasping, and also have so have influence on therapeutic effect.Medicine of the present invention source is abundant, and processing technology is simple, converges each phase diagnosis and prescription in a stove, and technology is easy to grasp and popularize, and is ideal, promising disease that calls for specialized treatment medication therefore.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of suppurative osteomyelitis, this medicine has the convergence open sore part, quickens bone tissue growth, promotes callus formation, accelerates the effect of sinus tract healing.
Another object of the present invention provides the preparation method of this medicine.
The solution of the present invention is based on motherland's medical science to osteomyelitis and pathogenetic understanding and Therapeutic Principle, and with reference to the modern pharmacological research achievement, through research for many years, the screening arrangement proposes from tens of kinds of medicines.
The invention provides a kind of medicine for the treatment of suppurative osteomyelitis, it is to be made by the raw material components of following weight parts:
Radix Astragali 20-40, Radix Angelicae Sinensis 10-30, Hippocampus 20-40, Sanguis Draxonis 8-15, Catechu 8-15, Olibanum (processed) 10-30, Myrrha (processed) 10-30, Colla Corii Asini 10-30, Rhizoma Drynariae 10-30, Cornu Cervi Degelatinatum 10-30 and Spina Gleditsiae 10-30.
Preferably treat in the medicine of suppurative osteomyelitis in the present invention, the weight portion ratio range of each raw material components is:
Radix Astragali 25-35, Radix Angelicae Sinensis 15-25, Hippocampus 25-35, Sanguis Draxonis 10-13, Catechu 10-13, Olibanum (processed) 15-25, Myrrha (processed) 15-25, Colla Corii Asini 15-25, Rhizoma Drynariae 15-25, Cornu Cervi Degelatinatum 15-25 and Spina Gleditsiae 15-25.
In the medicine of the most preferred treatment suppurative osteomyelitis of the present invention, the weight portion proportioning of each raw material components is:
The Radix Astragali 30, Radix Angelicae Sinensis 20, hippocampus 30, Sanguis Draxonis 12, Catechu 12, Olibanum (processed) 20, Myrrha (processed) 20, Colla Corii Asini 20, Rhizoma Drynariae 20, Cornu Cervi Degelatinatum 20 and Spina Gleditsiae 20; Or
The Radix Astragali 35, Radix Angelicae Sinensis 25, Hippocampus 25, Sanguis Draxonis 10, Catechu 10, Olibanum (processed) 25, Myrrha (processed) 25, Colla Corii Asini 25, Rhizoma Drynariae 25, Cornu Cervi Degelatinatum 25 and Spina Gleditsiae 15; Or
The Radix Astragali 25, Radix Angelicae Sinensis 15, hippocampus 35, Sanguis Draxonis 11, Catechu 13, Olibanum (processed) 15, Myrrha (processed) 25, Colla Corii Asini 20, Rhizoma Drynariae 20, Cornu Cervi Degelatinatum 15 and Spina Gleditsiae 20.
The present invention also provides the preparation method of the medicine of treatment suppurative osteomyelitis, it comprises dries pulverize altogether with the Radix Astragali, Radix Angelicae Sinensis, Hippocampus, Rhizoma Drynariae, Spina Gleditsiae, cross 120 mesh sieves, Sanguis Draxonis, Catechu are ground to the powder altogether, the Colla Corii Asini piece is smashed with stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE and is become Colla Corii Asini bead to grind to the powder, after deoiling, Olibanum, Myrrha grind to the powder, Cornu Cervi Degelatinatum is to stay clinker after Cornu Cervi is endured cream, smash pulverization, with above-mentioned whole powder be mixed in proportion stir evenly after, under 100 ℃-120 ℃, carry out the ripening sterilization treatment 20-30 minute, promptly make medicine after the cooling.
Medicine of the present invention is capsule formulation preferably.
The present invention also provides the preparation method of treatment suppurative osteomyelitis medicament capsule, and it comprises that the medicine that will prepare by the said medicine preparation method incapsulates.
Instructions of taking
Each oral former medicine 3 grams of adult as being the capsule of 1 gram in dosage, are taken three, every day secondary, children's is cut down according to the circumstance, 40 is the course of treatment.As the big person of sinus tract mouth, also this medicine can be spread on outward in the sinus tract mouth.The short state of an illness the lighter of disease time takes a course of treatment and can cure; If the with the passing of time heavier person of the state of an illness obeys two courses of treatment, be no more than three courses of treatment at most, do not see any toxic and side effects.
How chronic suppurative osteomyelisis is general is transformed by acute, the inventor must be empty according to traditional Chinese medical science prolonged illness, whole body clinical performance beyond the theory of sick much cold for a long time and the focus that primary disease presented (count as body weakness, pale complexion, spiritlessness and weakness, night sweat spontaneous perspiration, loss of appetite, pale tongue white and thin fur, pulse condition etc.), think that primary disease is a deficiency of vital QI, deficiency complicated with excess is answered strengthening vital QI to eliminate pathogenic factors in the treatment, attack the benefit combination, internal and external application, diagnosis and prescription.According to its insufficiency of kidney-YANG that shows, deficiency of both QI and blood, so that the main symptom that descends of local muscle skeleton resistance, Radix Astragali tonifying Qi and lifting yang in the side, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, is to be principal agent; Chinese angelica blood supplementing is invigorated blood circulation, and the Hippocampus warming the kidney to invigorate YANG is altogether for auxiliary; Catechu, Olibanum, Myrrha convergence granulation promoting, clots absorbing detumescence, the Spina Gleditsiae expelling pus and toxin by strengthening QI; The same usefulness of Cornu Cervi Degelatinatum and Hippocampus, the power multiplication of strengthening yang and invigorating kidney, the effect of expelling pus and promoting granulation is more apparent; Colla Corii Asini is the tangible product of flesh and blood, and the hemopoietic of enriching blood, granulation promoting are put on flesh.All medicines share, and the energy benefiting vital QI and blood encourages healthy trends, and it is evil to drive away poison, promoting tissue regeneration and ulcer healing, and bone and muscle strengthening is to obtain full merit.Assistant makes essence come blood multiple with YIN nourishing in this group medicine YANG invigorating; Take into account YANG invigorating in the YIN nourishing, make equilibrium between yin and yang, all medicines cooperatively interact, and lump together, and curative effect shows.After taking, the patient is conscious, and whole body is warm, and is energetic, swollen disappears soon, and pus row is smooth, and it is good that skin ulcer is held back, and flesh is given birth to new, and sclerotin is grown, and callus is formed, and sinus tract is repaired, so the speed that disease heals also.
Modern pharmacological research proves that multiple medicines such as Huang, Hippocampus, Cornu Cervi Degelatinatum have immunoregulation effect, can improve body's immunological function; Multiple medicines such as Radix Angelicae Sinensis, Colla Corii Asini, Olibanum (processed) have the sanguimotor effect of adjusting, can increase whole body and partial blood supply; Spina Gleditsiae, Catechu, Rhizoma Drynariae have broad-spectrum antiseptic and antivirus action, can get rid of evils and go out; Sanguis Draxonis, Myrrha (processed) have analgesia and antiinflammatory action, help the improvement of corresponding symptom.What these medicines formed makes a concerted effort, and just in time the cause of disease and the mechanism with chronic suppurative osteomyelisis formation is harmonious, with the cognitive consonance of modern medicine, so can give play to good effect.
Specific embodiment
Embodiment 1: the medicament capsule of preparation treatment suppurative osteomyelitis
Take by weighing raw material (gram) by following proportioning:
The Radix Astragali 30, Radix Angelicae Sinensis 20, hippocampus 30, Sanguis Draxonis 12, Catechu 12, Olibanum (processed) 20, Myrrha (processed) 20, Colla Corii Asini 20, Rhizoma Drynariae 20, Cornu Cervi Degelatinatum 20, Spina Gleditsiae 20.
Production method is as follows:
Oven dry such as the Radix Astragali, Radix Angelicae Sinensis, Hippocampus, Rhizoma Drynariae, Spina Gleditsiae are total to pulverize, cross 120 mesh sieves, Sanguis Draxonis, Catechu are ground to the powder altogether, and the Colla Corii Asini piece is smashed with stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE and is become Colla Corii Asini bead to grind to the powder, and grinds to the powder after Olibanum, Myrrha deoil, Cornu Cervi Degelatinatum is to stay clinker after Cornu Cervi is endured cream, smash pulverization, with whole powder mix according to the above ratio stir evenly after, under 100 ℃-120 ℃, carried out the ripening sterilization treatment 20-30 minute, after the cooling, incapsulate (No. 0).
Embodiment 2: the medicament capsule of preparation treatment suppurative osteomyelitis
Take by weighing raw material (gram) by following proportioning:
The Radix Astragali 35, Radix Angelicae Sinensis 25, Hippocampus 25, Sanguis Draxonis 10, Catechu 10, Olibanum (processed) 25, Myrrha (processed) 25, Colla Corii Asini 25, Rhizoma Drynariae 25, Cornu Cervi Degelatinatum 25, Spina Gleditsiae 15.
Production method is with embodiment 1.
Embodiment 3: the medicament capsule of preparation treatment suppurative osteomyelitis
Take by weighing raw material (gram) by following proportioning:
The Radix Astragali 25, Radix Angelicae Sinensis 15, hippocampus 35, Sanguis Draxonis 11, Catechu 13, Olibanum (processed) 15, Myrrha (processed) 25, Colla Corii Asini 20, Rhizoma Drynariae 20, Cornu Cervi Degelatinatum 15, Spina Gleditsiae 20.
Production method is with embodiment 1.
Efficacy experiment
For showing the therapeutic effect of medicine of the present invention to chronic suppurative osteomyelisis, the present invention treats 90 routine patients, male's 72 examples wherein, women's 18 examples; The oldest person 45 years old, reckling 12 years old; The shortest person of the course of disease 3 months, elder is for 8 years.In clinical experiment, also set up western medicine and medical practitioners treatment group and traditional Chinese medical science conventional therapy group simultaneously, respectively select 30 routine patients and the present invention to compare observation at random.The western medicine and medical practitioners group adopts the antibiotic conventional therapy, uses the hands art during invalid or poor effect instead; Traditional Chinese medical science conventional therapy group, according to the traditional Chinese medical science by stages, typing " the treatment standard " issued with national departments concerned is the standard medication.Three groups treatment time all is decided to be 60 days, and therapeutic outcome is all according to unified treatment standard determination (seeing the following form).
Clinical cure is meant that symptom all disappears, and sinus tract heals fully, and the inspection of X sheet does not have sequestrum, and it is normal that sclerotin recovers, functional rehabilitation.
Three groups of treatment situation comparison sheets
The treatment number Average cure time (my god) Pure cured substance number (people) Companion's surgical healing number (people) Cure rate (%)
Of the present invention group of the conventional group of the western medicine and medical practitioners group traditional Chinese medical science 30 30 90 54 53 42 15 18 90 12 10 0 91% 94% 100%
More as can be known, though three kinds of methods all have reliable therapeutic effect, of the present invention group 90 example makes the patient avoid the hardship of operation, this one all by cured substance from last table; Treatment time of the present invention obviously is better than other two groups, and the shortest has only used 20 days, and the longest also has only 58 days, makes the patient be subjected to ailing the torment less, and can reduce patient's medical expenses, saves resource medicine, this its two; The cure rate of the present invention in the identical time also is higher than other two groups, and do not have repeatedly.All cases there is no recurrence through following up a case by regular visits to more than 5 years, prove that it has unique effect.In addition, observe according to clinical and many cases case history X-ray, the present invention has the effect of tangible promotion bone tissue growth, favourable union of fracture.So the present invention is a specially good effect to the treatment chronic suppurative osteomyelisis not only, and also has the good effect that promotes that fracture heals early.
Model case
Case 1
In light, the man, 25 years old, went to river in the Dan Cheng county the two groups of peasants in village the Zhoukou City, Henan.Go to a doctor at 10 o'clock in the morning on April 20th, 1998.
Patient's cause in March right lower extremity outside is bumped against with the desk angle and is seen limbs pain, redness, treats.The about 4 millimeters sinus tract of diameter appears in pars affecta skin after 1 month, and pus goes out incessantly, and discharges with hard block.Satisfy and come examination in hospital, through having a medical check-up and X-ray film making is defined as " right tibia hypomere chronic osteomyelitis ".The medicated powder that is about to the present invention after debridement is packed to affected part, and measures oral this medicine of adhering on request.After treating 30 days altogether, sinus tract mouth closure, the healing of skin ulcer face; X-ray examination confirms the sequestrum discharge.Afterwards, follow up a case by regular visits to every year once, patient body is strong, does not see recurrence.
Case 2
Wang Haishan, man, 40 years old, the 4 groups of peasants in the Zhai Zhen king of Luoyang City, Henan seven villages.Go to a doctor at 2 o'clock in afternoon on August 13rd, 1998.
The patient was hit the left side shank by ironware before 2 years accidentally, symptoms such as pain, limitation of activity promptly occurred, was diagnosed as " left tibia hypomere comminuted fracture " hospitalization then.After union of fracture was left hospital 1 month, operative incision place soft tissue began erosion, had the about 5 millimeters sinus tract of a diameter to form then, had yellow pus to discharge frequently, and accidental black lump thing.Go to see a doctor once more,, be diagnosed as " left tibia hypomere old fracture companion osteomyelitis " through a corpse or other object for laboratory examination and chemical testing and X-ray examination.After the debridement promptly with the present invention's medicated powder (measure in accordance with regulations and take medicine every day), external for oral administration (medicated powder is packed to affected part, and periodic replacement), dispenser simultaneously.Sinus tract closure, ulcer surface disappear after 27 days; X-ray examination, sequestrum is discharged.Afterwards, follow up a case by regular visits to every year once, patient's lower limb are strong as ordinary person, do not see recurrence.

Claims (8)

1, a kind of medicine for the treatment of suppurative osteomyelitis is characterized in that it is to be made by the raw material of following weight parts:
Radix Astragali 20-40, Radix Angelicae Sinensis 10-30, Hippocampus 20-40, Sanguis Draxonis 8-15, Catechu 8-15, Olibanum (processed) 10-30, Myrrha (processed) 10-30, Colla Corii Asini 10-30, Rhizoma Drynariae 10-30, Cornu Cervi Degelatinatum 10-30 and Spina Gleditsiae 10-30.
2, the medicine of the described treatment suppurative osteomyelitis of claim 1 is characterized in that the weight portion proportioning of each raw material is:
Radix Astragali 25-35, Radix Angelicae Sinensis 15-25, Hippocampus 25-35, Sanguis Draxonis 10-13, Catechu 10-13, Olibanum (processed) 15-25, Myrrha (processed) 15-25, Colla Corii Asini 15-25, Rhizoma Drynariae 15-25, Cornu Cervi Degelatinatum 15-25 and Spina Gleditsiae 15-25.
3, the medicine of the described treatment suppurative osteomyelitis of claim 2 is characterized in that the weight portion proportioning of each raw material is:
The Radix Astragali 30, Radix Angelicae Sinensis 20, hippocampus 30, Sanguis Draxonis 12, Catechu 12, Olibanum (processed) 20, Myrrha (processed) 20, Colla Corii Asini 20, Rhizoma Drynariae 20, Cornu Cervi Degelatinatum 20 and Spina Gleditsiae 20.
4, the medicine of the described treatment suppurative osteomyelitis of claim 2 is characterized in that the weight portion proportioning of each raw material is:
The Radix Astragali 35, Radix Angelicae Sinensis 25, Hippocampus 25, Sanguis Draxonis 10, Catechu 10, Olibanum (processed) 25, Myrrha (processed) 25, Colla Corii Asini 25, Rhizoma Drynariae 25, Cornu Cervi Degelatinatum 25 and Spina Gleditsiae 15.
5, the medicine of the described treatment suppurative osteomyelitis of claim 2 is characterized in that the weight portion proportioning of each raw material is:
The Radix Astragali 25, Radix Angelicae Sinensis 15, hippocampus 35, Sanguis Draxonis 11, Catechu 13, Olibanum (processed) 15, Myrrha (processed) 25, Colla Corii Asini 20, Rhizoma Drynariae 20, Cornu Cervi Degelatinatum 15 and Spina Gleditsiae 20.
6, the medicine of the described treatment suppurative osteomyelitis of any one of claim 1-5 is characterized in that described medicine is a capsule.
7, the preparation method of the medicine of the described treatment suppurative osteomyelitis of any one of claim 1-5, it is characterized in that it comprises the Radix Astragali, Radix Angelicae Sinensis, Hippocampus, Rhizoma Drynariae, the Spina Gleditsiae oven dry is pulverize altogether, cross 120 mesh sieves, with Sanguis Draxonis, Catechu grinds to the powder altogether, the Colla Corii Asini piece is smashed with stir-baked in powder of CONCHA MERETRICIS SEU CYCLINAE and is become Colla Corii Asini bead to grind to the powder, Olibanum, Myrrha grinds to the powder after deoiling, Cornu Cervi Degelatinatum is to stay clinker after Cornu Cervi is endured cream, smash pulverization, with above-mentioned whole powder be mixed in proportion stir evenly after, under 100 ℃-120 ℃, carry out the ripening sterilization treatment 20-30 minute, promptly make medicine after the cooling.
8, the preparation method of the medicine of the described treatment suppurative osteomyelitis of claim 7 is characterized in that also comprising medicine is incapsulated.
CNB200510085598XA 2004-11-30 2005-07-29 Medicine for curing pyogenic osteomyelitis and process for preparing the same Expired - Fee Related CN1315509C (en)

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CN106581378B (en) * 2016-12-31 2020-04-07 胡鲲 Traditional Chinese medicine ointment for treating chronic pyogenic osteomyelitis and preparation method thereof
CN113425746A (en) * 2021-06-25 2021-09-24 楚东开 Composition for treating pyogenic osteomyelitis and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1216252A (en) * 1997-11-03 1999-05-12 王廷明 Capsule for skin infection and ulceration of skin and consumption

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1216252A (en) * 1997-11-03 1999-05-12 王廷明 Capsule for skin infection and ulceration of skin and consumption

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