CN1304775A - Therpeutic method by implantating miniature radioactive source in tumor tissue and its implantator - Google Patents
Therpeutic method by implantating miniature radioactive source in tumor tissue and its implantator Download PDFInfo
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- CN1304775A CN1304775A CN 00127851 CN00127851A CN1304775A CN 1304775 A CN1304775 A CN 1304775A CN 00127851 CN00127851 CN 00127851 CN 00127851 A CN00127851 A CN 00127851A CN 1304775 A CN1304775 A CN 1304775A
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Abstract
A therapeutic method for treating tumor by implantating miniature radioactive source in the tumor tissue features that a software system for 3D-image endoradiation therapy is used to precisely calsulate the data of CT or magnetic resonance tomography and the 3D graph is drawn to plan precise therapy scheme. An implantator is also disclosed, which has an anti-radiation rotary disk to directionally implant the solid radiation source in the tumor or the tissue infiltrated by tumor. Its advantages include no need of operation, radiotherapy and chemicotherapy, high effect and low cost.
Description
The present invention relates to a kind of interior radiotherapy in the treatment method of tumor and use instrument, particularly a kind of inter-planting of organizing of tumor is gone into the Therapeutic Method and the implantation device thereof of miniature radioactive source.
Clinical diagnosis at present is the patient of cancer, it more than 95% II～III phase, total operative treatment rate is no more than 30%, the effect of treatment with chemotherapy is greatly about about 30%, and bring numerous complication to the patient, treatment with chemotherapy can cause side effect such as leukopenia, nausea and vomiting, alopecia, xerosis cutis, has a strong impact on patient's quality of life.In nearly more than half century, medical circle is used Comprehensive Treatments such as operation and radiotherapy and is obtained more significantly progress.Radiotherapy is to use operation back heavy dose short time (a few minutes) repeatedly to shine (comprising remote outer radiotherapy and after-loading therapy).Patient's life is prolonged, but the quality of life that exists the patient can be subjected to bigger interference.The malignant tumor of splanchnocoel easily causes the residual deficiency that waits of tumor because of the target center inaccuracy.Radiotherapy is meant in the mini-radioactive resource implantation tumour or be subjected in the tissue of tumor-infiltrated infringement between cancerous tissue, send lasting low-energy gamma-rays by mini-radioactive resource, make tumor tissues killed and wounded by maximum destructiveness, normal structure is not damaged or microlesion only arranged.Have report the twenties, but the transmitted intensity of radium is big, the half-life is longer with radium needle treatment carcinoma of tongue.The development of man-made isotope radioactive source in recent years is rapid,
198Au,
125I,
103The man-made isotope radioactive source half-life such as pd are shorter than radium, and activity produces the heat spot that damages normal structure by force and not to the lethality of tumor, is easy to protection, medically bringing into play bigger therapeutical effect.Chinese patent CN9105575 has introduced a kind of " radiotheraping method and device in the body " that adapts to kinds of tumors in the human body.This method is earlier conduit to be inserted tumor locus in the human body before treatment.Radioactive source is sent into tumor locus by pipeline and is carried out radiotherapy.Whole device is only joined the steel wire rope of one one end band radioactive substance, before will being with a radioactive end to send into pipeline, to not deliver to therapentic part by pipeline earlier, as hindered, will deliver to therapentic part with the other end of radioactive substance again and treat with the other end of radioactive substance.It is uncontrollable and lack the shortcoming that suppresses the tumor diffusion that this Therapeutic Method and device all exist radioactive substance.
The object of the present invention is to provide a kind of stereotaxis that prevents and suppress that tumor spreads between tumor tissues, to implant the Therapeutic Method and the implantation device thereof of solid-state mini-radioactive resource.
The object of the present invention is achieved like this: the inter-planting of organizing of tumor is gone into the Therapeutic Method of miniature radioactive source, adopt three-dimensional image internal radiotherapy planning software system that the data of CT or magnetic resonance demixing scan sheet is carried out accurate Calculation, draw three-dimensional icon with the space of a whole page of Chinese, calculate the implantation metering of mini-radioactive resource according to the intensitometer of radioactive source, be implanted in the tumor or be subjected to the distribution of mini-radioactive resource in the tissue of tumor-infiltrated infringement, work up accurate therapeutic scheme.Mini-radioactive resource is sealed in the titanium alloy housing.Method for implantation is that the miniature radiation source implantation equipment pricker that wears long is punctured to mini-radioactive resource in the tumor or is subjected in the tissue of tumor-infiltrated infringement, comprises implantable miniature radioactive source in the tissue of tumor lympha diffusion path.Can adopt through various breasts, peritoneoscope, B ultrasonic guiding and other image-guided and be punctured in the tumor and may spread position implantable miniature radioactive source.Or cooperate operation technique simultaneously in the situation to tumor resection fully, at tissue of bordering on tumor and the position implantable miniature radioactive source that may spread.To can not excise or can only the situation of part tumor resection in, in tumor or remaining tumor and the position implantable miniature radioactive source that may spread.
A kind of tumor tissues inter-planting is gone into the implantation device of miniature radioactive source, it is characterized in that this implantation device is provided with the fiveshooter formula radioprotective rotating circular disk [6] of placing mini-radioactive resource, is provided with the mini-radioactive resource storage hole of continuous distribution in the disk.This implantation device comprises a metal shell [2], housing can be an overall structure or synthetic by two, the rotating circular disk [6] that has a two sides to be provided with radioprotective cover plate [9] is installed in the housing, the end face of rotating circular disk has rotation fixed card slot [8], install one on the housing and rotate joystick [1], rotate joystick and pass housing, in stage clip frame [13] and alignment pin [14] are housed, with rotating [12] capping of joystick lid, alignment pin [14] engages with the rotation fixed card slot, the side of rotating circular disk is provided with the storage hole [7] of mini-radioactive resource along circumference, at rotating circular disk, radioprotective cover plate side and case side face corresponding position are provided with fixing hole and pass through center fixation bolt [5], set bolt [10] is connected and fixed.Be respectively equipped with back injection orifice [11], guide pin through hole [3] and mini-radioactive resource implantation hole in the side of housing and the corresponding position, storage hole of rotating circular disk, implanting at mini-radioactive resource has rotatory sealing lid [4] on the hole.Guide pin through hole [3] is gone up installation one and is with graduated puncture needle, and push rod is arranged in the pin.
The invention has the beneficial effects as follows: the present invention utilizes three-dimensional image internal radiotherapy planning software system to use puncture technique and be with graduated puncture needle maybe may spread the position in the mini-radioactive resource implantation tumour by the miniature radiation source implantation equipment, both can the killing tumor cells tissue, can prevent and suppress the diffusion of tumor again, continue low dosage can extremely reduce tumor sublethal damage district cell in the radiotherapy of tumor quantity, for tumour patient obtains best treatment time section, need neither to wait for that the wound healing physical efficiency recovery implements other Comprehensive Treatment again, controlled simultaneously that the silent tumor cell is activated and the process that doubles, effectively reduced the relapse rate behind the oncotherapy.The inventive method tumor-localizing accurately, can accurately calculate the radiation metering, adopt mini-radioactive resource, the principle of applications distances effect does not have radiation injury substantially to patient's responsive organ.Avoided the radiation injury of family numbers of patients simultaneously because of accompanying the patient to be subjected to.Be sealed in the intravital radioactive source of titanium alloy shell and completely cut off the body fluid environment of human body, thereby can not absorbed, do not have of the influence of patient's Excreta environment by metabolism.Its implantation device adopts the disk of metal shell sealing to supply with continuously, has shielded the gamma-rays radiation of mini-radioactive resource substantially.Avoided the radiation damage of radioactive source to medical worker and patient, can shorten the time of implanted treatment greatly, its medical expense descends about 50% than prices such as outer Coega external exposure, X-ray cuttves.
Description of drawings
Fig. 1 looks schematic cross-section for the master of implantation device of the present invention
Fig. 2 is the left view of implantation device of the present invention
1 rotates joystick among the figure, 2 metal shells, 3 guide pin through holes, 4 rotatory sealings lid, 5 center fixation bolts, 6 rotating circular disks, 7 mini-radioactive resources storage hole, 8 rotation fixed card slots, 9 radioprotective cover plates, 10 set bolts, 11 back injection orifices, 12 rotate joystick lid, 13 stage clip framves, 14 alignment pins
The invention will be further described below in conjunction with accompanying drawing
Embodiment 1: adopt
125The I mini-radioactive resource,
125The half-life of I is 60 days, energy is the 35.5Kev gamma-rays, make the iodine grain of shell with the 0.8mm*4.5mm of titanium alloy sealing, implant the mini-radioactive resource storage hole 7 of putting into rotating circular disk in the hole by the mini-radioactive resource on the implantation device housing, cover 4 screwing hermetics with rotatory sealing, adopt three-dimensional image internal radiotherapy planning software system that the data of CT or magnetic resonance demixing scan sheet is carried out accurate Calculation, draw three-dimensional icon with the space of a whole page of Chinese, calculate the placement metering of mini-radioactive resource according to the intensitometer of radioactive source, design is in tumor or be subjected in the tissue of tumor-infiltrated infringement, comprise the distribution of mini-radioactive resource in the tissue of tumor lympha diffusion path, work up accurate therapeutic scheme.Rotate rotating circular disk 6, mini-radioactive resource storage hole 7 and back injection orifice 11, guide pin through hole 3 are corresponding, utilize the pin inner push-rod can be with mini-radioactive resource by in the tumor of graduated syringe needle implant into body and may spread the position.As a man, 72 years old, gastric cancer late period was with gastrorrhagia, and the capable emergency operation in 25, of 98 on Decembers finds in the art that huge cancer can't excise, and there is ascites in the abdominal cavity, through family members' requirement, implants at tumor ulcer basilar part serosal surface
1259 pieces of I grains, second day after operation, stopped bleeding.
Embodiment 2: man, 41 years old, behind the rectal cancer surgery 1 year, the a plurality of transfers of two lungs, chemotherapy effect is not good, the capable superior lobe of left lung excision of 98.11.10,98.12.27 row right lung operation, focus be inferior lobe, diameter 6cm, infringement is every flesh, with the right inferior pulmonary vein adhesion, patient's pulmonary function is relatively poor, should not go the bottom right pneumonectomy, the excision of appeasing property of focus row, residual affected area is implanted
12513 pieces of I grains, postoperative patient occur breathing urgent, through ICU monitoring, rehabilitation after three days.
Embodiment 3: the woman, and 57 years old, behind the left radical operation of mastocarcinoma 2 years, left clavicle lymphatic metastasis up and down, chemotherapy and outer radiotherapy effect are not good, and 99.1.7 accepts radiotherapy between tissue, focus 5cm under the clavicle, implantation
1259 pieces of I grains, focus 1.5cm on the clavicle implants
1252 pieces of I grains, postoperative three all focuses all disappear.
Embodiment 4: woman, 61 years old, right side colon hepatic metastases, 99.1.12 the row right hemicolectomy, hepatic artery catheterization is put pump, because of the about 3cm metastasis of hepatic portal portion is oppressed first hepatic portal, chemotherapy can not in time be implemented, and for preventing postoperative jaundice and ascites, implants in the first hepatic portal focus
1258 pieces of I grains, postoperative rehabilitation is smooth, leaves hospital after January, does not use chemotherapy, jaundice also do not occur.
Embodiment 5: the woman, 63 years old, right hepatic metastases appearred in ovarian cancer post operation 8 years, right lung and every the flesh metastatic carcinoma, the capable inferior lobe of right lung of 99.1.13, every flesh and the excision of right hepatic metastases kitchen range.The nearly caval vein of right liver top focus place has residual, implants
1258 pieces of I grains, postoperative rehabilitation is smooth.
Claims (8)
1, a kind of inter-planting of organizing of tumor is gone into the Therapeutic Method of miniature radioactive source, with in the mini-radioactive resource implantation tumour or be subjected in the tissue of tumor-infiltrated infringement, send lasting low-energy gamma-rays by mini-radioactive resource, make tumor tissues killed and wounded by the destructiveness of fatal dose, normal structure is not damaged or microlesion only arranged, it is characterized in that adopting three-dimensional image internal radiotherapy planning software system that the data of CT or magnetic resonance demixing scan sheet is carried out accurate Calculation, draw three-dimensional icon with the space of a whole page of Chinese, calculate the placement metering of mini-radioactive resource according to the intensitometer of radioactive source, design is in tumor or distributed by the solid of mini-radioactive resource in the tissue of tumor-infiltrated infringement, work up accurate therapeutic scheme, mini-radioactive resource is sealed in the titanium alloy housing, method for implantation is that the miniature radiation source implantation equipment pricker that wears long is punctured to mini-radioactive resource in the tumor or is subjected in the tissue of tumor-infiltrated infringement, comprises implantable miniature radioactive source in the tissue of tumor lympha diffusion path.
2, the inter-planting of organizing of a kind of tumor according to claim 1 is gone into the Therapeutic Method of miniature radioactive source, it is characterized in that mini-radioactive resource is implanted maybe may to spread position implantable miniature radioactive source by various breasts, laparoscopic use puncture technique in tumor.
3, the inter-planting of organizing of a kind of tumor according to claim 1 is gone into the Therapeutic Method of miniature radioactive source, it is characterized in that the mini-radioactive resource implantation is by using puncture technique in the surgical operation, to the complete tumor resection of energy, at tissue of bordering on tumor and the position implantable miniature radioactive source that may spread, in can't the tumor of complete resection, maybe can't use in the tumor of operation technique and the position implantable miniature radioactive source that may spread because of anatomical factors.
4, the inter-planting of organizing of a kind of tumor according to claim 1 is gone into the Therapeutic Method of miniature radioactive source, it is characterized in that to perform a surgical operation in the tumour patient that maybe can't be treated surgically, mini-radioactive resource is by the guiding of B ultrasonic guiding or other iconographys, and the application puncture technique directly is punctured to tumor through skin and is implanted into mini-radioactive resource.
5, a kind of tumor tissues inter-planting is gone into the implantation device of miniature radioactive source, it is characterized in that this implantation device is provided with the fiveshooter formula radioprotective rotating circular disk [6] of placing mini-radioactive resource, is provided with the mini-radioactive resource storage hole [7] of continuous distribution in the disk.
6, a kind of tumor tissues inter-planting according to claim 5 is gone into the implantation device of miniature radioactive source, it is characterized in that this implantation device comprises a metal shell [2], housing can be an overall structure or synthetic by two, the rotating circular disk [6] that has a two sides to be provided with radioprotective cover plate [9] is installed in the housing, the end face of rotating circular disk has rotation fixed card slot [8], install one on the housing and rotate joystick [1], rotate joystick and pass housing, in stage clip frame [13] and alignment pin [14] are housed, with rotating [12] capping of joystick lid, alignment pin [14] engages with the rotation fixed card slot, the side of rotating circular disk is provided with the storage hole [7] of mini-radioactive resource along circumference, at rotating circular disk, radioprotective cover plate side and case side face corresponding position are provided with fixing hole and pass through holding screw [5], set bolt [10] is connected and fixed, be respectively equipped with back injection orifice [11] in the side of housing and the corresponding position, storage hole of rotating circular disk, guide pin through hole [3] and mini-radioactive resource are implanted the hole, and implanting at mini-radioactive resource has rotatory sealing lid [4] on the hole.
7, go into the implantation device of miniature radioactive source according to a kind of tumor tissues inter-planting according to claim 5, it is characterized in that described radioprotective cover plate [9] made by radiation proof material, thickness is 2-4mm.
8, go into the implantation device of miniature radioactive source according to a kind of tumor tissues inter-planting according to claim 5, it is characterized in that going up installation one at guide pin through hole [3] is with graduated puncture needle, has push rod in the pin.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00127851 CN1304775A (en) | 2000-12-12 | 2000-12-12 | Therpeutic method by implantating miniature radioactive source in tumor tissue and its implantator |
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| CN 00127851 CN1304775A (en) | 2000-12-12 | 2000-12-12 | Therpeutic method by implantating miniature radioactive source in tumor tissue and its implantator |
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| CN1304775A true CN1304775A (en) | 2001-07-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641561B (en) * | 2004-02-20 | 2017-08-25 | 佛罗里达大学研究基金会公司 | For providing conformal radiation therapy while the system being imaged to soft tissue |
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2000
- 2000-12-12 CN CN 00127851 patent/CN1304775A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641561B (en) * | 2004-02-20 | 2017-08-25 | 佛罗里达大学研究基金会公司 | For providing conformal radiation therapy while the system being imaged to soft tissue |
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