CN1289162C - Variable focus body high energy concentrating ultrasonic tumor therapy system - Google Patents
Variable focus body high energy concentrating ultrasonic tumor therapy system Download PDFInfo
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- CN1289162C CN1289162C CN 02133319 CN02133319A CN1289162C CN 1289162 C CN1289162 C CN 1289162C CN 02133319 CN02133319 CN 02133319 CN 02133319 A CN02133319 A CN 02133319A CN 1289162 C CN1289162 C CN 1289162C
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Abstract
The present invention relates to a high-energy focusing ultrasonic tumor treating system with a variable focus body. A plurality of ultrasonic generating units (2) are arranged on a focusing supporting base (1), each ultrasonic generating unit (2) is provided with a piezoelectric wafer which is connected with a power electric source (8), the focusing supporting base (1) is connected with a mechanical hand (3) which is connected with an I /O interface (9) by a driver (6), the I/O interface is connected with a computer (17), the focusing supporting base (1) is connected with a medium storage (18), and the power electric source (8) is connected with the I/O interface (9). The energy and the frequency of the focus body can be regulated according to the practical situation of a tumor, and the present invention achieves a good treatment effect by an optimal incidence angle.
Description
Technical field:
The present invention with utilize energy focusing ultrasonic-high in burnt body, to produce effect to come the therapy equipment of kill tumor tissue relevant.
Technical background:
Ultrasound wave is a kind of mechanical wave, utilizes ultrasonic vibrational energy can change character such as the structure of matter, state, function.Ultrasonic therapy is that ultrasonic energy is acted on human body, utilizes its machinery, heat energy and cavitation effect, to the tissue effect, causes the physiological effect of body, reaches the purpose of treatment disease.
Energy focusing ultrasonic-high does not have wound treatment tumor with respect to the general means of existing oncotherapy such as operative treatment, chemicotherapy, has unrivaled advantage.Patient does not have wound, to the radiation injury and the chemicals influence of human body, can not produce the general infringement to human body, can not produce infringement to the immune system of human body yet.Therefore, energy focusing ultrasonic-high treatment tumor will more and more be subject to people's attention.
The quality quality of energy focusing ultrasonic-high oncotherapy depends primarily on the performance of supersonic focus therapeutic device.The focusing of present energy focusing ultrasonic-high therapy equipment ultrasonic beam is generally adopted geometric lens, physics lens or transducer is directly made the concave surface battle array realize focusing on.The direction of these sound beam focusings, focal length, frequency all are fixed, and often need adjust the parameters of focus and focus size, position, frequency etc. according to the state of an illness in the ultrasonic therapeutic, and energy focusing ultrasonic-high treatment tumor also should satisfy some specification requirements; The real-time monitoring of the location of knub position and treatment is followed the tracks of, the operation control of ultrasonic burnt body, the control of ultrasonic radiation dosage etc.
The content of invention:
Purpose of the present invention provides a kind of compact conformation, and utilization is flexibly, and is safe and reliable, the treatment accurate positioning, and therapeutic effect is good, the regulatable variable focus body high energy concentrating ultrasonic tumor therapy system of the motion of ultrasonic burnt body and parameters.
The present invention is achieved in that
Variable focus body high energy concentrating ultrasonic tumor therapy system of the present invention, assemble on the bearing 1 some ultrasonic generating units 2 are arranged, ultrasonic generating unit 2 is arranged as some circles on gathering bearing 1, the ultrasonic generating unit of every circle is the piezoelectric chip of different natural frequencies, each ultrasonic generating unit 2 all connects with corresponding power power-supply 8, each ultrasonic generating unit 2 produces assembles ultrasound wave, carry out secondary focusing by focusing on bearing 1 again, the input of mechanical hand 3 is passed through driver 6 respectively with output, pick off 7 is connected with I/O interface 9, I/O interface 9 is connected with computer 17, pick off 7 detects mechanical hand 3 information, 3 motions of driver 6 driving device handss, focusing on bearing 1 is connected with the integrated platform 16 in medium accumulating storehouse 18, integrated platform 16 is in transmission connection with mechanical hand 3, in the medium accumulating storehouse 18 ultrasonic couplant is housed, couplant surrounds suffers from position skin, and power power-supply 8 is connected with I/O interface 9.
Focusing on bearing 1 is parabolic housing, and ultrasonic generating unit 2 constitutes some concentric gardens on housing, and each 2 bottom, unit is a piezoelectric chip, and the top is parabolic, and towards the paraboloidal focus of bearing.
Focus on bearing 1 and be installed in platform 16 centres, the platform periphery is tightly connected with an end of flexible flexible corrugated tube 15, and the other end of corrugated tube and medium accumulating storehouse 18 centre bore peripheries are tightly connected, and platform 16 is connected with five coordinate mechanical hands 3.Intrinsic motor and actuating device 31 on the platform 16, two pick offs 7 on the platform 16 are connected with I/O interface 9.
Have centering body 14 to be positioned at platform 16 tops, be fixed with Ultrasonic-B probe on the rotary extension arm of centering body, B ultrasonic machine 5 is connected with I/O interface 9.
Have ill respiration pickup 10 usefulness suckers to be adsorbed on the patient affected part, its output signal is connected with I/O interface 9 through signal conditioning circuit 4.
Power power-supply 8 comprises high power switching power supply 19, its output is connected with ultrasonic-frequency power supply 21 through dynamic frequency variable connector 20, the output of power supply 21 is switched electrical switch 22 by dominant frequency and is connected with piezoelectric ceramic wafer 24, Switching Power Supply 19 is connected with the I/O interface by adjust blood pressure output circuit 25, variable connector 20, ultrasonic-frequency power supply 21, electrical switch 22 is respectively by photoelectrical coupler 26,27,28 are connected with the I/O interface, and electrical switch 22 is connected with the I/O interface by DSP circuit 29.
Have adaptation module 23 respectively with ultrasonic-frequency power supply 21, electrical switch 22 is connected with piezoelectric ceramic wafer 24.
Compact conformation of the present invention, utilization are treated accurate positioning flexibly.Can be according to tumor location in vivo and the image three-dimensional reconstruction data in computer, provide the shape of the burnt body of best energy focusing ultrasonic-high by the computer therapy specialist system, energy and frequency size, need to determine the ultrasonic generating unit of work by these parameters, these cell operation of computer control, carry out work with the burnt body near tumor shape, can reduce moving of focusing therapy device like this, improve therapeutic efficiency, simultaneously according to the tumor practical situation, adjust the energy and the frequency of burnt body, projectile energy and incident frequency with the best reach the Efficient and Flexible therapeutic effect.
The present invention can guarantee that Ultrasonic-B probe detects and the location by the motion centering body.Can handle flexibly by mechanical hand, guarantee that high-energy ultrasonic has optimal incident angle in fact, can be moving by breathing TT﹠C system, follow the tracks of the trouble displacement that causes by breathing, real time control machine tool hands is had good positioning treatment.
Description of drawings:
Fig. 1 block diagram of the present invention.
Fig. 2 is the power power-supply block diagram.
Fig. 3 is for focusing on seat structure figure.
Fig. 4 is ultrasonic generating unit structure chart.
Fig. 5 is the systematic treating flow chart.
The specific embodiment:
High-energy ultrasonic focusing therapy device is the key of whole therapy system, it is parabolic housing that focusing therapy device of the present invention basic unit focuses on bearing 1,24 through holes with the level are arranged on the housing, that these 24 through holes are divided on focusing on bearing is interior, in, Wai Sanquan, eight through holes of uniform distribution on every circle circumference, the parabolic curvature difference of the bearing of every ring through hole correspondence, through-bore axis is consistent with the parabolic normal of the bearing of through hole position.24 ultrasonic generating unit 2 profiles and shape of through holes consistent size cooperate respectively to embed in the through hole, form concentric circular annular transducer array.Each bonding piezoelectric ceramic wafer in ultrasonic generating unit bottom, the piezoelectric chip natural frequency difference of each circle, eight ultrasonic generating unit piezoquartzes of centre circle adopt a kind of frequency, eight ultrasonic generating units of inner ring adopt two kinds of different frequencies respectively, eight the ultrasonic generating units in outer ring also adopt two kinds of different frequencies, be that 24 ultrasonic generating unit piezoquartzes have five kinds of different frequencies on the focusing therapy device, each piezoelectric chip has lead to insert each self-corresponding ultrasonic power power supply 8.Ultrasonic generating unit 2 tops also are parabolic, and towards the paraboloidal focus of bearing.The piezoelectric chip excited target of each ultrasonic generating unit bottom produces ultrasound wave, and ultrasonic beam arrives ultrasonic generating unit top by ultrasonic generating unit entity, by the parabola refraction focusing at top.Each ultrasonic generating unit once focuses on regard to having carried out the ultrasonic beam of sending like this, has formed the focus of little different frequency.Adjust the angle that each ultrasonic generating unit axis and basic unit focus on the bearing normal, the ultrasound wave that ultrasonic generating unit is focused on focuses on bearing by basic unit again and is focused into the multifrequency burnt body of multiple shape for the second time.Combination in any mode of operation in eight ultrasonic generating units of centre circle focuses on the burnt body that is focused into definite shape on the paraboloidal axis of symmetry at basic unit's bearing, as main treatment focus energy body; The ultrasonic generating unit of inside and outside circle can be adjusted in the centre burnt body top/bottom latitude and arrange the focus that generating unit separately focuses on.The focusing therapy device can be combined into burnt shape of best treatment and energy frequency size by computer control according to the tumor shape position like this.Each ultrasonic generating unit all has corresponding power power-supply in the focusing therapy device, therefore computer can be controlled the duty of each ultrasonic generating unit, any several piezoelectric chips are worked simultaneously in such 24 ultrasonic generating units, can be combined into multiple burnt shape, energy, mode of operation that frequency is different.
Single-phase 220V alternating current is connected with high power switching power supply, for the focusing therapy head provides power supply, specialist system in the computer system and knowledge base export adjust blood pressure interface 25 to through decision-making, adjust blood pressure interface 25 is connected with high power switching power supply 19 and for it provides the control input, high power switching power supply output is connected with dynamic frequency switch 20 and provides the self check input for it.Specialist system in the computer system 17 is connected dominant frequency with knowledge base through decision-making output and switches electrical switch 22, dominant frequency is switched electrical switch 22 and is connected with piezoelectric ceramic wafer 24, computer control system is determined the optimal dose of the required sound intensity according to different knub positions and shape, burnt shape and frequency are controlled the parameters such as dynamic frequency, duty parameter of dynamic frequency variable connector 20.Dynamic frequency variable connector 20 exports ultrasonic-frequency power supply 21 to, and ultrasonic-frequency power supply 21 is system power supplies of corresponding piezoelectric transducer array 24, and its output is switched electrical switch through dominant frequency and is connected to each corresponding transducer.The switching or the switch of dominant frequency switching optical coupler are controlled according to the state of an illness by computer.So just can realize the various combination mode of operation of each ultrasonic generating unit,,, adjust the burnt body sound intensity, frequency, shape flexibly, parameters such as focal length by computer control according to the actual needs of treatment.
The focusing therapy device is installed in a circular platform centre, away from circular central position mounted movable centering body 14, motion centering body 14 revolve on the semi-girder fixedly Ultrasonic-B probe, at another side fixed drive motor 6 and two alignment sensors 7 of round platform 16, constitute a treatment motion centering integrated platform like this.When 5 work of needs B ultrasonic machine, the driver 6 of motion centering body, receiving computer order (or manual command) drives Ultrasonic-B probe and accurately navigates to focusing therapy device center front, to guarantee Ultrasonic-B probe display surface image definite coordinate position is arranged; When the focusing therapy device needed work, Ultrasonic-B probe follow procedure control command (or manual command) was driven away from focusing therapy device wave surface allocation really by the motion centering body, to guarantee the focusing therapy utensil good focusing performance is arranged.
The circular periphery of integrated platform 16 is connected with the end sealing of flexible flexible corrugated tube 15, and the other end of flexible bellow is connected with the periphery sealing of the centre bore that is fixed on container 18 bottoms on the therapeutic bed, thereby forms medium accumulating storehouse.In the accumulating storehouse by the negative pressure degassed water as ultrasonic couplant, couplant surrounds patient skin, to guarantee Ultrasonic-B probe or the good acoustic impedance coupled characteristic of focusing therapy device in the diagnosis and treatment process.
Breathing TT﹠C system is that respiratory movement transducer 10 usefulness suckers are adsorbed on the patient affected part, the displacement that brings is breathed in induction, pick off is through signal condition 4, input computer interface system 9, computer 17 is according to these trouble position respiratory movement data of gathering in real time, real time control machine tool hands 3 is followed the tracks of owing to breathe moving of the trouble position of causing.
To further specify operating process of the present invention below:
The patient is prostrate on therapeutic bed, suffers from the position matrix and is positioned at the therapeutic bed centre bore, and the patient is adsorbed respiratory movement transducer 10 on one's body, detects patient's respiratory movement, and data insert computer interface system 9.It is medium accumulating storehouse 18 that the patient suffers from the below, position, and entering water electromagnetic valve is opened, and the negative pressure degassed water is injected in the accumulating storehouse, and liquid level sensor detects accumulating storehouse water level, is closed by the computer control entering water electromagnetic valve during to predetermined water level.Liquid level sensor is monitored accumulating storehouse SEA LEVEL VARIATION in real time, surpasses predetermined water level when water level reduces, and the computer control electromagnetic valve is opened and replenished out air water.Motion centering body 14 rotates to focusing therapy device center with Ultrasonic-B probe, and by doctor's manipulator robot on computers, control B probe checks with the optimum position and suffer from the position, and gathers the B ultrasonic image and be stored to computer.Computer is handled the B ultrasonic image that checks out, and demarcates again, reconstructs the 3D shape of tumor, determines the tumor locus.After tumor table shape position was determined, focusing therapy device center was left in the Ultrasonic-B probe rotation.The information that computer is gathered according to tumor by the treatment specialist system or under the doctor in charge instructs, is determined diagnosis and treatment robot movement track, parameters such as the burnt shape of high-energy ultrasonic, energy, frequency.At first implement examination and control scheme: 1) select best examination to control the region point position, implement the examination of some bit position motion or focus ultrasonic dosage and control; 2) by Ultrasonic-B probe area grayscale is controlled in examination and detected, obtain motor control sum of errors dosage deviation, calculate and determine that deviation compensation, formulates new examination and control a position, try again to control scheme implementation, until the best.Implement therapeutic scheme again: 1) control targeting scheme, confirm that each aspect motion and focus ultrasonic dosage have reached the best according to examination.2) implement the continuous path therapeutic scheme.In the therapeutic process, computer real-time is handled the respiratory movement transducer signal of gathering, and determines the respirometric compensation dosage of tracking of diagnosis and treatment mechanical hand, makes the interior burnt volume tracing of body suffer from the position and moves with breathing.
Claims (7)
1, variable focus body high energy concentrating ultrasonic tumor therapy system, it is characterized in that assembling some ultrasonic generating units (2) are arranged on the bearing (1), ultrasonic generating unit (2) is arranged as some circles on gathering bearing (1), the ultrasonic generating unit of every circle is the piezoelectric chip of different natural frequencies, each ultrasonic generating unit (2) all connects with corresponding power power-supply (8), each ultrasonic generating unit (2) produces assembles ultrasound wave, carry out secondary focusing by focusing on bearing (1) again, the input of mechanical hand (3) is passed through driver (6) respectively with output, pick off (7) is connected with I/O interface (9), I/O interface (9) is connected with computer (17), pick off (7) detects mechanical hand (3) information, driver (6) driving device hands (3) motion, focusing on bearing (1) is connected with the integrated platform (16) in medium accumulating storehouse (18), integrated platform (16) is in transmission connection with mechanical hand (3), in the medium accumulating storehouse (18) ultrasonic couplant is housed, couplant surrounds suffers from position skin, and power power-supply (8) is connected with I/O interface (9).
2, system according to claim 1, it is characterized in that focusing on bearing (1) is parabolic housing, and ultrasonic generating unit (2) constitutes some concentric gardens on housing, and each unit (2) bottom is a piezoelectric chip, the top is parabolic, and towards the paraboloidal focus of bearing.
3, system according to claim 1 and 2, it is characterized in that focusing on bearing (1) and be installed in platform (16) centre, the platform periphery is tightly connected with an end of flexible flexible corrugated tube (15), the other end of corrugated tube and medium accumulating storehouse (18) centre bore periphery are tightly connected, platform (16) is connected with five coordinate mechanical hands (3), platform (16) is gone up intrinsic motor and actuating device (31), and two pick offs (7) on the platform (16) are connected with I/O interface (9).
4, system according to claim 1 and 2, (14) are positioned at platform (16) top to it is characterized in that centering body is arranged, and are fixed with Ultrasonic-B probe on the rotary extension arm of centering body, and B ultrasonic machine (5) is connected with I/O interface (9).
5, system according to claim 1 is characterized in that having patient respiratory pick off (10) to be adsorbed on the patient affected part with sucker, and its output signal is connected with I/O interface (9) through signal conditioning circuit (4).
6, system according to claim 1, it is characterized in that power power-supply (8) comprises high power switching power supply (19), its output is connected with ultrasonic-frequency power supply (21) through dynamic frequency variable connector (20), the output of power supply (21) is switched electrical switch (22) by dominant frequency and is connected with piezoelectric ceramic wafer (24), Switching Power Supply (19) is connected with the I/O interface by adjust blood pressure output circuit (25), variable connector (20), ultrasonic-frequency power supply (21), electrical switch (22) is respectively by photoelectrical coupler (26,27,28) be connected with the I/O interface, electrical switch (22) is connected with the I/O interface by DSP circuit (29).
7, system according to claim 6, it is characterized in that adaptation module is arranged (23) respectively with ultrasonic-frequency power supply (21), electrical switch (22) is connected with piezoelectric ceramic wafer (24).
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CN 02133319 CN1289162C (en) | 2002-06-21 | 2002-06-21 | Variable focus body high energy concentrating ultrasonic tumor therapy system |
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CN 02133319 CN1289162C (en) | 2002-06-21 | 2002-06-21 | Variable focus body high energy concentrating ultrasonic tumor therapy system |
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CN1289162C true CN1289162C (en) | 2006-12-13 |
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Cited By (1)
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CN104510530A (en) * | 2013-09-29 | 2015-04-15 | 柯惠有限合伙公司 | Cable management system for medical treatment device |
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CN100558427C (en) * | 2006-07-14 | 2009-11-11 | 重庆海扶(Hifu)技术有限公司 | A kind of apparatus for ultrasonic therapeutic treatment |
CN105999569B (en) * | 2016-05-04 | 2019-03-12 | 中国科学院深圳先进技术研究院 | A kind of array element selection device of more element transducers, method and ultrasound stimulation system |
CN107917740A (en) * | 2017-12-28 | 2018-04-17 | 西安石油大学 | The double-frequency ultrasound wave transducer of biphase gas and liquid flow flow measurement |
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CN104510530A (en) * | 2013-09-29 | 2015-04-15 | 柯惠有限合伙公司 | Cable management system for medical treatment device |
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