CN1283463A - Process for preparing solid-state-microspherical vascular suppository of sodium alginate - Google Patents
Process for preparing solid-state-microspherical vascular suppository of sodium alginate Download PDFInfo
- Publication number
- CN1283463A CN1283463A CN 00123459 CN00123459A CN1283463A CN 1283463 A CN1283463 A CN 1283463A CN 00123459 CN00123459 CN 00123459 CN 00123459 A CN00123459 A CN 00123459A CN 1283463 A CN1283463 A CN 1283463A
- Authority
- CN
- China
- Prior art keywords
- sodium alginate
- state
- microspherical
- weight
- calcium chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 14
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 14
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 14
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 title claims description 10
- 230000002792 vascular Effects 0.000 title claims description 8
- 239000000829 suppository Substances 0.000 title claims description 7
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 7
- 239000001110 calcium chloride Substances 0.000 claims abstract description 6
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 6
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 239000003643 water by type Substances 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 201000004108 hypersplenism Diseases 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000007711 solidification Methods 0.000 abstract 1
- 230000008023 solidification Effects 0.000 abstract 1
- 208000005189 Embolism Diseases 0.000 description 5
- 208000001435 Thromboembolism Diseases 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- -1 iron ion Chemical class 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
A solid microspherical sodium alginate for treating in travascular thrombosis is prepared from aqueous solution of sodium alginate and calcium chloride through cross-linking solidification. Its advantages are high curative effect and high target sensitivity. It can also be used to treat tumor, hypersplenism, thyroidism, etc.
Description
The present invention relates to the production method of medicament preparation, specifically relate to the solid-state-microspherical vascular suppository of sodium alginate production technology of (being called for short KMG).
One of main component of Thallus Laminariae (Thallus Eckloniae) is a sodium alginate, people are more to sodium alginate research, wherein Japan Patent 639542 is mentioned: be joined into insoluble sodium salt with water miscible alginic acid molecule in preparation, firming agent is polyvalent metal ion, as calcium, iron ion etc., but the production technology of undeclared solid-state-microspherical vascular suppository of sodium alginate.
Purpose of the present invention provide a kind of fast, the production technology of efficient production solid-state-microspherical vascular suppository of sodium alginate.
Technical scheme of the present invention is: sodium alginate is made 4～8 weight % pure water solutions, heat 70～90 ℃, add cross-linking agent 0.5～2 weight % calcium chloride, cool to room temperature, left standstill 12～24 hours, spray downwards by 20～26G model injection needle with 1～3 times of atmospheric pressure, the container that injection fills 6～10 weight % calcium chloride waters sieves.
The advantage of KMG production technology of the present invention is that operation is uncomplicated, output is big, the efficient height, after the KMG of 0.1～0.4mm particle diameter product injects blood vessel, swollen immediately ratio all is suitable for environment in the human body small artery, KMG can play the thromboembolism curative effect of the permanent thromboembolism of target vessel, itself not participating in the body internalization thanks, the form degraded of can molecule after 3 months taking off chain disappears, do not produce noxious substance in the degradation process, do not produce chip, and general solid-state vascular occlusive agent, as gelfoam, silicone rubber, polylactic acid, ethyl cellulose, polyvinyl alcohol etc., when injecting blood vessel and after the injection, might or be subjected to the influence of antiotasis to break away from target tissue or target organ with the blood impact of flowing backwards, cause secondary damage, and KMG of the present invention is unique the swelling character that adapts with human body arteriolar embolism position arranged, this characteristic is promptly located swelling after making it inject target organ, do not rechange the thromboembolism position, and the KMG product there are the various chemotherapy of adding, the DEVELOPMENT PROSPECT of radiotherapy targeted drug and tracer.Add iron powder, can make it have magnetropism, add magnetic in the target organ orientation when injecting blood vessel, can make the targeting thromboembolism more accurate.
In the time of the present patent application patent, applied for patent of invention again: denomination of invention is: the detection method of the swelling pressure of solid-state-microspherical vascular suppository of sodium alginate.
With regard to an embodiment, the present invention is further specified below
Embodiment:
In having the container of reflux, add pure water 93.5 grams, sodium alginate 6.5 grams, make 6.5% aqueous solution, stir on the limit, the limit is heated to 78 ℃, make solution become the thick liquid of homogeneous, add 1% calcium chloride solution and stir well, be cooled to room temperature, left standstill 18 hours, this solution is added spray thrower, spray downwards, inject the container that fills 10% calcium chloride water with the injection needle of 2 times of atmospheric pressures by the 22G model, be cross-linkable solidifying be microsphere, sieve, with 0.1 and the mesh screen of 0.4mm, obtain the KMG of 0.1～0.4mm particle diameter.
All production processes are all carried out in 100 grades of super-clean environments, after the KMG packing, encapsulate finished product after can putting high pressure, high temperature, sterilization.
Claims (1)
1, the production technology of solid-state-microspherical vascular suppository of sodium alginate, it is characterized in that: sodium alginate is made 4～8 weight % pure water solutions, heat 70～90 ℃, add cross-linking agent 0.5～2 weight % calcium chloride, cool to room temperature, left standstill 12～24 hours, spray downwards by 20～26G model injection needle with 1～3 times of atmospheric pressure, inject the pocket that fills 6～10 weight % calcium chloride waters, sieve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00123459 CN1106845C (en) | 2000-08-17 | 2000-08-17 | Process for preparing solid-state-microspherical vascular suppository of sodium alginate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00123459 CN1106845C (en) | 2000-08-17 | 2000-08-17 | Process for preparing solid-state-microspherical vascular suppository of sodium alginate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1283463A true CN1283463A (en) | 2001-02-14 |
| CN1106845C CN1106845C (en) | 2003-04-30 |
Family
ID=4589889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00123459 Expired - Fee Related CN1106845C (en) | 2000-08-17 | 2000-08-17 | Process for preparing solid-state-microspherical vascular suppository of sodium alginate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1106845C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006108324A1 (en) * | 2005-04-15 | 2006-10-19 | Beijing Shengyiyao Science & Technology Development Co., Ltd | A gynecological pharmaceutics-containing microspherical vascular suppository of sodium alginate and its preparation method |
| CN1313156C (en) * | 2004-02-06 | 2007-05-02 | 北京圣医耀科技发展有限责任公司 | Sodium alginate microglobule blood vessel suppositery containing gynecoiatry medicine and its preparation method |
| CN1876177B (en) * | 2005-06-06 | 2011-06-01 | 北京圣医耀科技发展有限责任公司 | Biodegradable material microsphere blood vessel suppository containing liposome cell factor and its preparation and uses |
| CN108992431A (en) * | 2018-09-30 | 2018-12-14 | 重庆医科大学附属永川医院 | A kind of Doxorubicin embolism microball and preparation method thereof |
| CN115245143A (en) * | 2022-07-06 | 2022-10-28 | 上海市中西医结合医院 | Construction method of artery occlusive disease animal model |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319525C (en) * | 2004-09-16 | 2007-06-06 | 北京圣医耀科技发展有限责任公司 | Taxinol-sodium alginate micro ball vascular embolism agent and its preparation |
| CN101077424B (en) * | 2006-05-25 | 2011-04-06 | 范恒华 | Blood vessel bonding anastomosis sealant and kit |
-
2000
- 2000-08-17 CN CN 00123459 patent/CN1106845C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1313156C (en) * | 2004-02-06 | 2007-05-02 | 北京圣医耀科技发展有限责任公司 | Sodium alginate microglobule blood vessel suppositery containing gynecoiatry medicine and its preparation method |
| WO2006108324A1 (en) * | 2005-04-15 | 2006-10-19 | Beijing Shengyiyao Science & Technology Development Co., Ltd | A gynecological pharmaceutics-containing microspherical vascular suppository of sodium alginate and its preparation method |
| EA013680B1 (en) * | 2005-04-15 | 2010-06-30 | Бейцзин Шенияо Сайнс Энд Текнолоджи Девелопмент Ко., Лтд. | Microspherical vascular embolus of sodium alginate containing a gynecological pharmaceutics and preparation thereof |
| CN1876177B (en) * | 2005-06-06 | 2011-06-01 | 北京圣医耀科技发展有限责任公司 | Biodegradable material microsphere blood vessel suppository containing liposome cell factor and its preparation and uses |
| CN108992431A (en) * | 2018-09-30 | 2018-12-14 | 重庆医科大学附属永川医院 | A kind of Doxorubicin embolism microball and preparation method thereof |
| CN108992431B (en) * | 2018-09-30 | 2020-10-09 | 重庆医科大学附属永川医院 | Doxorubicin embolism microsphere and preparation method thereof |
| CN115245143A (en) * | 2022-07-06 | 2022-10-28 | 上海市中西医结合医院 | Construction method of artery occlusive disease animal model |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1106845C (en) | 2003-04-30 |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING SENGYIYAO TECHNOLOGY DEVELOPMENT CO., LTD Free format text: FORMER OWNER: ZHANG XINGUO Effective date: 20010904 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20010904 Address after: 100071, room 98, 228 Fengtai Road, Beijing, Fengtai District Applicant after: Beijing Shengyiyao Science & Technology Development Co., Ltd. Address before: 100039 No. 69, Yongding Road, Haibin District, Beijing Applicant before: Zhang Xinguo |
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| ASS | Succession or assignment of patent right |
Owner name: HONG HONG; LU GE Free format text: FORMER OWNER: BEIJING SENGYIYAO TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20020104 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20020104 Applicant after: Hong Hong Applicant after: Lu Ge Applicant before: Beijing Shengyiyao Science & Technology Development Co., Ltd. |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20030430 Termination date: 20190817 |
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| CF01 | Termination of patent right due to non-payment of annual fee |