CN1279054A - Optically Chronatographic imaging method and equipment with focusing, ultraconic wave and modulation - Google Patents
Optically Chronatographic imaging method and equipment with focusing, ultraconic wave and modulation Download PDFInfo
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- CN1279054A CN1279054A CN 00117208 CN00117208A CN1279054A CN 1279054 A CN1279054 A CN 1279054A CN 00117208 CN00117208 CN 00117208 CN 00117208 A CN00117208 A CN 00117208A CN 1279054 A CN1279054 A CN 1279054A
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Abstract
An optically chromatographic imaging method features that the focusing and ultrasonic wave are used to modulate the laser beam transmitted to deep tissue and locate the tissue, the optical technique is used for high-sensitivity sensing, and real-time fast Fourier transform (FFT) is used to process signals to obtain a chromatographic image with high S/N ratio. Its imaging equipment is composed of laser, ultrasonic unit, photoelectric converter, real-time FFT module, and computer. Its advantages include no damage and high sensitivity.
Description
The present invention relates to a kind of biomedical video diagnostic technology, be specifically related to a kind of combine concentration ultrasonic location and optics not damaged detect two kinds of technical characterstics, be used for method and device thereof to biological tissue's tomography.
Present widely used video chromatographic technique, for example x-ray tomography (CT), NMR (Nuclear Magnetic Resonance)-imaging etc. all have certain damage to tissue, and x-ray tomography device, nuclear magnetic resonance equipment cost are very expensive; Though B-type ultrasonography does not have damage substantially, the instrument cost is also lower, but owing to be organizational interface's catoptric imaging, can't realize chromatography, resolution is also lower (to the in-vivo tissue of simple structure, best resolution is several millimeters), and resolution further descends when checking the organ of motion, so these imaging techniques all are subjected to certain limitation when clinical practice.In order to overcome the shortcoming of these imaging techniques, enrich diagnostic means, new chromatography imaging technique has obtained broad research, and wherein the most noticeable is the optical image chromatographic technique.It is a kind of Dynamic Non-Destruction Measurement, not only optical detection precision higher (resolution can reach micron dimension), and can carry out functional imaging, this has great importance for the pathological tissues of distinguishing in the vivo biological tissue, because some pathological tissues physical characteristic or outward appearance and normal structure do not have difference or difference very little, imaging examination method with routine can't be observed, just can distinguish normal structure and pathological tissues and use to function imaging of biological tissue, benign lesion and malignant change, yet, because biological tissue is to the strong scattering and the absorption of light, present technical merit can only reach the shallow-layer biological tissue imaging of the degree of depth for the millimeter magnitude, is difficult to reach deep tissues is accurately measured.
The objective of the invention is to focus supersonic location technology and optical image chromatographic technique are combined, utilize the advantage of the two, be that ultrasound wave is to the better penetration capacity of tissue and the higher characteristics of non-destructive, precision of optical image chromatography method, and adopt high-sensitivity detection technology and Fourier transformation technology real-time, a kind of focus supersonic modulated optical chromatography imaging method of suitable medical imaging diagnosis is provided.
Another object of the present invention is to provide a kind of focus supersonic modulated optical laminated imaging device of realizing said method.
For achieving the above object, focus supersonic modulated optical video chromatography method of the present invention comprises the steps: that (one) wavelength is that the laser of 630nm-1000nm incides in the biological tissue of containing scattering and absorption; (2) frequency is that the ultrasound wave of 0.5MHz～10MHz focuses in the biological tissue that laser beam passes through and forms the modulation areas that a size is equivalent to ultrasound focus; (3) collect by opto-electronic conversion optical signal to be converted into the signal of telecommunication from the scattering laser of ultrasonic modulation areas; (4) utilize real-time Fourier transformation to carry out signal spectrum and separate, extract modulation signal; (5) Computer Processing signal and carry out image reconstruction obtains the tomographic map of biological tissue.
Usable frequency is that the low frequency signal of 50Hz～20kHz carries out amplitude modulation(PAM) to described ultrasound wave, carries out demodulation when processing signals.
The wavelength of described laser the best is the 690nm-860nm in biological tissue's characteristic absorption scope.
The device of realizing this focus supersonic modulated optical video chromatography method is by laser instrument, ultrasound wave generating assembly, light collector, photoelectric conversion component, data collecting card, Fourier transformation module, 3-D scanning assembly, computer are formed real-time; Wherein the ultrasound wave generating assembly is made of functional generator, power amplifier, ultrasonic transducer, focus ultrasonic lens, and functional generator, power amplifier, ultrasonic transducer are electrically connected successively, and ultrasonic transducer is fixedlyed connected with the focus ultrasonic lens; This position and annexation of installing each assembly is that light collector is connected by optical coupling with photoelectric conversion component, photoelectric conversion component, data collecting card, Fourier transformation module, computer are electrically connected successively real-time, computer again with supersonic generator, 3-D scanning assembly by being electrically connected control ultrasound emission and signals collecting.Light collector receives the laser through the testee scattering, is converted to the signal of telecommunication by photoelectric conversion component then; Data collecting card is a digital signal with this conversion of signals, carries out image reconstruction work again by Fourier transformation resume module real-time, and by computer.
Described ultrasound wave generating assembly also can comprise low frequency signal generator, and its and function generator is electrically connected, and the output low frequency amplitude-modulated signal makes it to produce the signal of telecommunication by the supersonic frequency of amplitude modulation(PAM) to the latter.
Compared with prior art, the present invention has following advantage: (one) combines that ultrasound wave has stronger penetration capacity to biological tissue and the optical image tomography has advantages such as high-resolution, high sensitivity, not damaged, can not produce radiation injury to organism, so compare with traditional medical imaging diagnosis method have not damaged, sensitivity is good, resolution is high advantage, can significantly improve pathological changes diagnosis ability for biological tissue; (2) adopt signal behind the modulating action of Fourier transformation technical finesse real-time, chaotic complicated time-domain signal can be changed into the frequency-region signal of clear and definite, obtain the required modulation signal of imaging with comparalive ease, significantly improve signal to noise ratio; (3) this method can be carried out amplitude modulation(PAM) to ultrasonic beam with low frequency signal.Biological tissue is to the modulated response sensitivity of the modulated response comparison upper frequency (as supersonic frequency) of lower frequency, thus the easier detection of low frequency modulations scattered light signal, but low-frequency sound wave all is not so good as ultrasound wave to penetration capacity and the focusing power of organizing.This method can be used the high-frequency ultrasonic that is loaded with low-frequency modulation signal, penetration capacity and focusing power are realized high-resolution depth localization preferably to utilize ultrasonic beam, detect the low frequency signal that is loaded with in the high-frequency signal from focus point simultaneously and be embodied as picture, can significantly improve detectivity and signal to noise ratio; (4) imaging mechanism of this method is based on the modulation of ultrasound wave focusing place biological tissue, and when laser passed through this focus, the parameter of organizing of reflection biological properties was also modulated by ultrasound wave.The difference of modulation signal has reflected the difference of biological tissue's function, therefore available this method comes the multiple parameter of organizing of organism is carried out functional imaging, the life process of postgraduate's interior of articles, for example content of the pathological changes of research organization, blood volume, blood oxygen saturation, blood flow rate, water and the STRESS VARIATION of muscular tissue etc.(5),, use operation also more convenient so the production assembling is more or less freely because the structure of this device is comparatively simple.
Below in conjunction with accompanying drawing focus supersonic modulated optical video chromatography method of the present invention and device thereof are described in further detail.
Fig. 1 is the block diagram of focus supersonic modulated optical video chromatographic apparatus of the present invention;
Fig. 2 is the position view of cube in simulation medium of hiding;
Fig. 3 is simulation medium and the cubical tomographic map that utilizes Fig. 1 device to obtain;
Fig. 4 is another block diagram of focus supersonic modulated optical video chromatographic apparatus of the present invention;
Fig. 5 is simulation medium and the cubical tomographic map that utilizes Fig. 4 device to obtain;
Embodiment 1:
Fig. 1 shows the structure of this focus supersonic modulated optical video chromatographic apparatus, as seen from Figure 1, this device is by laser instrument 1, ultrasound wave generating assembly 2, light collector 3, photoelectric conversion component 4, data collecting card 5, Fourier transformation module 6, computer 7, D translation platform 12 are formed real-time; Wherein ultrasound wave generating assembly 2 is connected and composed successively by functional generator 2-1, power amplifier 2-2, ultrasonic transducer 2-3, focus ultrasonic lens 2-4; Light collector 3 and photoelectric conversion component 4 are connected by optical coupling, photoelectric conversion component 4, data collecting card 5, Fourier transformation module 6, computer 7 are electrically connected successively real-time, computer 7 again with supersonic generator 2,3-D scanning assembly 12 by being electrically connected control ultrasound emission and signals collecting.
Select for use each member to connect to form this device, wherein: laser instrument 1 is selected the relevant company of U.S. titanium gem ring laser for use, and can send wavelength is single mode redness or the iraser of 600nm～1100nm, and the optical maser wavelength that present embodiment adopted is 700nm; Functional generator 2-1 is selected the AFG320 type of U.S. Tektronix company for use; Power amplifier 2-2 is selected 2100L type (gain amplifier 50dB, the bandwidth 10kHz-12MHz) of U.S. ENI company for use; Ultrasonic transducer 2-3 is a disk piezoquartz, diameter 32mm, thick 2mm, and two discs are coated with conducting film, each connects a lead, form two electrodes, in an aluminium shell, one of them surface is exposed and is connected with focus ultrasonic lens 2-4 with adhesive curing; The sphere concavees lens that focus ultrasonic lens 2-4 select for use lucite to make have converging action to ultrasonic beam; Light collector 3 is selected the single-mode fiber of a band collecting lens for use, is specially the silica fibre of being furnished with collecting lens (core diameter 0.1mm, numerical aperture 0.37) that Nanjing glass fibre academy produces; The R374 type photomultiplier tube that photoelectric conversion component 4 selects for use Japanese Hamamatsu Photonics K. K to produce, and be furnished with refrigerator; Data collecting card 5 is selected the Compuscope12100 type high-speed collection card (acquisition rate is 100MHz) of Gage Applied company for use; Real-time Fourier transformation module 6 can be in real time be frequency spectrum (frequency domain) waveform with time (time domain) waveform transformation of signal, specifically can select the TDS3FFT type of U.S. Tektronix company for use; Computer 7 can be selected IBM 586 above microcomputers for use, and is furnished with the GPIB card; Sample cell 8 usefulness pmma materials are made, and have pair of windows in both sides, stud with quartzy window, and its thickness is 1mm, and sound-absorbing material 11 is arranged at the bottom of the pond, can adopt foam sponge; 12 is the D translation platform; Biological tissue's simulation medium 10 is to add scattering medium (INTRALIPID, 5%) and absorbing medium (TYPAN BLUE) formation in water, and its reduced scattering coefficient is 6.2cm
-1, absorptance is 0.1cm
-1, mimic destination organization is that (5mm * 5mm * 5mm), its reduced scattering coefficient is 10cm to a colloid cube
-1, absorptance is 0.1cm
-1, the cubical position of simulation medium and colloid as shown in Figure 2.
The implementation step that this method is concrete is: (one) sends wavelength by laser instrument 1 is that the laser of 700nm incides in the biological tissue's simulation medium 10 that contains scattering and absorption; (2) by the signal of telecommunication of computer 7 control function generators 2-1 generation supersonic frequency, be input to power amplifier 2-2, amplify rear drive ultrasonic transducer 2-3 and produce ultrasound wave, the frequency of ultrasonic that present embodiment adopted is 1MHz; Near ultrasound wave biological tissue's simulation medium 10 the focusing 9 after focus ultrasonic lens 2-4 focus on is modulated, and when laser beam passed through this zone, the parameter of organizing of reflection biological properties was also modulated by ultrasound wave; (3) scattering laser that contains modulation intelligence (for example, the light intensity that changes with supersonic frequency) is collected and is sent to photomultiplier tube 4 by light collector 3 and is converted into the signal of telecommunication; This signal of telecommunication is gathered by data collecting card 5, is input to Fourier transformation module 6 real-time; (4) adopt real-time that Fourier transformation module 6 changes this signal into frequency-region signal by time-domain signal, can obtain the modulation signal that the scattering laser medium frequency is 1MHz with comparalive ease, significantly improve signal to noise ratio; (5) move by computer 7 control D translation platforms 12, can realize plane scan; Measure the multiple spot modulation signal of any one tomography, handle, can carry out image reconstruction biological tissue's simulation medium 10 and destination organization through computer 7; Fig. 3 shows and adopts the effect of the inventive method to the colloid cube chromatography in biological tissue's simulation medium, and as seen from the figure, the inventive method simulates cubical shape of colloid and position in biological tissue's simulation medium preferably.
Embodiment 2:
Because biological tissue is to the modulated response sensitivity of the modulated response comparison upper frequency (as supersonic frequency) of lower frequency, thus the easier detection of low frequency modulations scattered light signal, but low-frequency sound wave all is not so good as ultrasound wave to penetration capacity and the focusing power of organizing.Present embodiment uses the high-frequency ultrasonic that is loaded with low-frequency modulation signal, penetration capacity and focusing power are realized high-resolution depth localization preferably to utilize ultrasonic beam, detect the low frequency signal that is loaded with in the scattered light medium-high frequency signal from focus point simultaneously and be embodied as picture, can significantly improve detectivity and signal to noise ratio.
As shown in Figure 4, ultrasound wave generating assembly 2 also comprises low frequency signal generator 2-5, low frequency signal generator 2-5 is inserted amplitude modulation (AM) signal input channel of the functional generator 2-1 of supersonic generator 2, incoming frequency is the sine wave signal of 1kHz, the supersonic frequency signal that functional generator 2-1 is produced carries out amplitude modulation(PAM), then the signal after this amplitude modulation is input to the input port of power amplifier 2-2; So the ultrasound wave that is produced by the ultrasonic transducer 2-3 of the signal of telecommunication of power amplifier 2-2 output and driving thereof all contains this amplitude-modulated signal; The signal that light collector 3 is received carries out demodulation: transfer time-domain signal to frequency-region signal by Fourier transformation module real-time 6, and at frequency domain signal is separated, extract the low frequency amplitude-modulated signal of 1kHz; Miscellaneous equipment, simulation medium and implementation step are with embodiment 1; Fig. 5 shows by the inventive method and adopts the ultrasound wave of the low frequency signal amplitude modulation of 1kHz to carry out the effect of biological tissue's simulation medium and colloid cube chromatography.As seen from the figure, adopt low frequency signal that the effect ultrasound wave is carried out amplitude modulation(PAM), separate the low frequency amplitude-modulated signal imaging in the scattered light again, can obtain tomographic map more clearly.
Claims (5)
1, a kind of focus supersonic modulated optical video chromatography method is characterized in that comprising the steps: that (one) wavelength is that the laser of 630nm-1000nm incides in the biological tissue of containing scattering and absorption; (2) frequency is that the ultrasound wave of 0.5MHz～10MHz focuses in the biological tissue that laser beam passes through and forms the modulation areas that a size is equivalent to ultrasound focus; (3) collect by opto-electronic conversion optical signal to be converted into the signal of telecommunication from the scattering laser of ultrasonic modulation areas; (4) utilize real-time Fourier transformation to carry out signal spectrum and separate, extract modulation signal; (5) Computer Processing signal and carry out image reconstruction obtains the tomographic map of biological tissue.
2, focus supersonic modulated optical video chromatography method according to claim 1 is characterized in that available 50Hz～20kHz low frequency signal carries out amplitude modulation(PAM) to described ultrasound wave, carries out demodulation when processing signals.
3, focus supersonic modulated optical video chromatography method according to claim 1 is characterized in that described Wavelength of Laser is the 690nm-860nm in biological tissue's characteristic absorption scope.
4, a kind of focus supersonic modulated optical video chromatographic apparatus is characterized in that by laser instrument, ultrasound wave generating assembly, light collector, photoelectric conversion component, data collecting card, Fourier transformation module, 3-D scanning assembly, computer are formed real-time; Wherein the ultrasound wave generating assembly is made of functional generator, power amplifier, ultrasonic transducer, focus ultrasonic lens, and functional generator, power amplifier, ultrasonic transducer are electrically connected successively, and ultrasonic transducer is fixedlyed connected with the focus ultrasonic lens; This position and annexation of installing each assembly is that light collector is connected by optical coupling with photoelectric conversion component, photoelectric conversion component, data collecting card, Fourier transformation module, computer are electrically connected successively real-time, computer again with supersonic generator, 3-D scanning assembly by being electrically connected control ultrasound emission and signals collecting.
5, focus supersonic modulated optical video chromatographic apparatus according to claim 4, it is characterized in that: described ultrasound wave generating assembly also can comprise low frequency signal generator, low frequency signal generator and function generator is electrically connected.
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Cited By (14)
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| CN1326492C (en) * | 2002-04-19 | 2007-07-18 | 维森盖特有限公司 | Variable-motion optical tomography of small objects |
| CN100434042C (en) * | 2004-01-06 | 2008-11-19 | 华南师范大学 | Method of biological tissue optical and ultrasonic collection and tomographic imaging and its device |
| CN100464185C (en) * | 2006-08-03 | 2009-02-25 | 长安大学 | Concrete ultrasound tomography algorithm |
| CN100495022C (en) * | 2006-08-03 | 2009-06-03 | 长安大学 | Concrete ultrasound tomography algorithm |
| CN101810467B (en) * | 2010-01-13 | 2011-08-24 | 中国科学院上海光学精密机械研究所 | Reflecting layer Fourier slice imaging method |
| CN103505243A (en) * | 2012-06-25 | 2014-01-15 | 美国西门子医疗解决公司 | Measuring acoustic absorption or attenuation of ultrasound |
| CN103932741A (en) * | 2014-03-14 | 2014-07-23 | 中瑞科技（常州）有限公司 | Tomography ultrasonic imaging system |
| WO2016131815A1 (en) * | 2015-02-16 | 2016-08-25 | Universität Rostock | Device and method for determining at least one mechanical property of an examined object |
| CN106456129A (en) * | 2014-05-22 | 2017-02-22 | 尼尔鲁斯工程股份公司 | Method for non-invasive optical measurement of properties of free-flowing blood |
| CN110954207A (en) * | 2019-11-15 | 2020-04-03 | 重庆医科大学 | Detection device and detection method for focused ultrasound focus sound wave structure |
| WO2020124474A1 (en) * | 2018-12-20 | 2020-06-25 | 深圳先进技术研究院 | Acoustic wave focusing lens and ultrasonic imaging device and method |
| CN111616707A (en) * | 2020-02-21 | 2020-09-04 | 天津大学 | Acousto-electric signal secondary decoding method based on Fourier approximation |
| CN112770677A (en) * | 2018-08-24 | 2021-05-07 | 数字谐波有限责任公司 | System and method for measuring vibration spectrum in living cells and tissues over time |
| CN114179537A (en) * | 2020-09-14 | 2022-03-15 | 东北大学秦皇岛分校 | Micro-transfer method and device for controlling SMP (symmetric multi-processing) seal based on focused ultrasound |
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2000
- 2000-06-27 CN CNB001172085A patent/CN1175784C/en not_active Expired - Fee Related
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1326492C (en) * | 2002-04-19 | 2007-07-18 | 维森盖特有限公司 | Variable-motion optical tomography of small objects |
| CN100434042C (en) * | 2004-01-06 | 2008-11-19 | 华南师范大学 | Method of biological tissue optical and ultrasonic collection and tomographic imaging and its device |
| CN100464185C (en) * | 2006-08-03 | 2009-02-25 | 长安大学 | Concrete ultrasound tomography algorithm |
| CN100495022C (en) * | 2006-08-03 | 2009-06-03 | 长安大学 | Concrete ultrasound tomography algorithm |
| CN101810467B (en) * | 2010-01-13 | 2011-08-24 | 中国科学院上海光学精密机械研究所 | Reflecting layer Fourier slice imaging method |
| CN103505243A (en) * | 2012-06-25 | 2014-01-15 | 美国西门子医疗解决公司 | Measuring acoustic absorption or attenuation of ultrasound |
| US9244169B2 (en) | 2012-06-25 | 2016-01-26 | Siemens Medical Solutions Usa, Inc. | Measuring acoustic absorption or attenuation of ultrasound |
| CN103932741B (en) * | 2014-03-14 | 2016-08-31 | 中瑞科技（常州）有限公司 | Tomography tangent plane ultrasonic image-forming system |
| CN103932741A (en) * | 2014-03-14 | 2014-07-23 | 中瑞科技（常州）有限公司 | Tomography ultrasonic imaging system |
| CN106456129B (en) * | 2014-05-22 | 2020-06-23 | 尼尔鲁斯工程股份公司 | Method for non-invasive optical measurement of flowing blood properties |
| CN106456129A (en) * | 2014-05-22 | 2017-02-22 | 尼尔鲁斯工程股份公司 | Method for non-invasive optical measurement of properties of free-flowing blood |
| WO2016131815A1 (en) * | 2015-02-16 | 2016-08-25 | Universität Rostock | Device and method for determining at least one mechanical property of an examined object |
| CN112770677A (en) * | 2018-08-24 | 2021-05-07 | 数字谐波有限责任公司 | System and method for measuring vibration spectrum in living cells and tissues over time |
| WO2020124474A1 (en) * | 2018-12-20 | 2020-06-25 | 深圳先进技术研究院 | Acoustic wave focusing lens and ultrasonic imaging device and method |
| CN110954207A (en) * | 2019-11-15 | 2020-04-03 | 重庆医科大学 | Detection device and detection method for focused ultrasound focus sound wave structure |
| CN111616707A (en) * | 2020-02-21 | 2020-09-04 | 天津大学 | Acousto-electric signal secondary decoding method based on Fourier approximation |
| CN111616707B (en) * | 2020-02-21 | 2023-04-18 | 天津大学 | Acousto-electric signal secondary decoding method based on Fourier approximation |
| CN114179537A (en) * | 2020-09-14 | 2022-03-15 | 东北大学秦皇岛分校 | Micro-transfer method and device for controlling SMP (symmetric multi-processing) seal based on focused ultrasound |
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