CN1274353C - Medication for curing children's infantile malnutrition and preparation method - Google Patents
Medication for curing children's infantile malnutrition and preparation method Download PDFInfo
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- CN1274353C CN1274353C CN 200410022272 CN200410022272A CN1274353C CN 1274353 C CN1274353 C CN 1274353C CN 200410022272 CN200410022272 CN 200410022272 CN 200410022272 A CN200410022272 A CN 200410022272A CN 1274353 C CN1274353 C CN 1274353C
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Abstract
The present invention discloses a medicine for preventing and curing infantile malnutrition and a preparation method thereof. The medicine is prepared by the way that amomun fruits, grassleaved sweetflag rhizome, aucklandia roots, dried tangerine peel and white atractylodes rhizome are distillated by water steam to extract volatile oil; the distillated residue, pseudostellaria roots, tuckahoe, bambooleaf thorowax, white peony roots, malt, selfheal spikes, Chinese yam, black plums, periostracum cicadae, haws and licorice roots are decocted with water twice, the time for the first decoction is 1 to 2 hours, and the time for the second decoction is 0.5 to 1.5 hours; filter liquors are combined and standing; supernatant liquid is taken and is concentrated to be in the specific gravity of 1.19 to 1.21 at the time of heat measurement, and then the supernatant liquid is cooled down to the room temperature; ethanol is added at the time of stirring until the alcohol content is from 65% to 75%, and ethanol stands still for 4 to 6 hours; the supernatant liquid is filtered; the ethanol is recovered until no ethanol flavor is left; the temperature is cooled down; auxiliary materials are added; the volatile oil is added. The medicine can be manufactured into various oral preparations, such as oral liquids, granules, capsules, mixtures, tablets, etc.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of preventing and treating infantile malnutrition, particularly relating to a kind of is the medicine that primary raw material is made with the vegetable Chinese herbal medicine.
Background technology
Infantile malnutrition is a kind of child's common frdquently encountered disease, always is one of department of pediatrics four big diseases (pox, fiber crops, frightened, infantile malnutrition), belongs to digestion, absorption, malnutrition syndrome.Qian Yi points out in key to Therapeutics of Children's Diseases: " infantile malnutrition is the spleen-stomach disease all, and the institute of depletion of body fluid does also ".Wang Kentang " Standards of Diagnosis and Treatment " is discussed: " on the whole infantile malnutrition be disease, all crosses the food and drink food, in tame one dirty have to amass do not control, dirty after the biography, form the disease of five kinds of child malnutrition.If spleen man disease is gone, then surplus dirty all peaces; It controls careless mistake, with the passing of time the change of disease must be arranged ".
" the spleen tending to insufficiency usually " is one of the physiological characteristics in children's period, so intemperance of taking food, particular about food, have a liking for the food fragrant and sweet raw food, easier to cause taste impaired, causes heat produced by dietary stagnation, consumes stomach-Yin, incoordination between the spleen and stomach, receives fortune and abnormal ascending-descending of QI, so poor appetite anorexia, abdominal distention or pain occur, urinate as water from washing rice; And then then cause weakness of the spleen and stomach, and essence of water and grain can not the compress skin and is guaranteed that whole body is grown and need, and so emaciation and sallow complexion occurs, body development is slow, resistance against diseases weakening; Incoordination between the spleen and stomach, it is uneasy then to sleep night." the liver being liable to excess " is children's's another physiological characteristics in period, and the easier edema with the liver involved ash that causes of weakness of the spleen and stomach is taken advantage of, and forms the weak liver-yang hyperactivity of spleen, so disposition agitation, active uneasiness occur, easily fly into a rage, rub eyebrow and dig nose, prostrate grinding tooth.
Pediatric Clinic is often run into because of yellow complexion, is become thin, inappetence, temper is strange or feel that often the infant of abdominal distention, stomachache goes to a doctor.This doctor trained in Western medicine is diagnosed as " slight malnutrition " more, only is according to the clinical symptoms complementary medicine, promotes protein adsorption as the injection anabolic hormone, replenishes multiple little give birth to plain and trace element, aminoacid etc.; Improve digestive and absorptive functions also for the medicine of some polyzyme tabletses, lactasinum and so on.But, owing to cure the symptoms, not the disease, fundamentally do not improve child's digestive and absorptive functions, therefore, can not reach gratifying curative effect.
Summary of the invention
The object of the present invention is to provide a kind of reasonable recipe, evident in efficacy, the medicine that drug safety, convenient for children are taken.Another object of the present invention provides the preparation method of this medicine.
Purpose of the present invention is achieved by following technical proposals.
Medicine of the present invention is made by following materials based on weight:
Radix Pseudostellariae 250～280 Rhizoma Atractylodis Macrocephalaes 250～280 Poria 200～240
HERBA BUPLEURI 200～240 Radix Paeoniae Albas 200～240 Pericarpium Citri Reticulataes 200～240
The Radix Aucklandiae 50～80 Fructus Amomis 90～130 Fructus Hordei Germinatus 310～350
Spica Prunellae 150～200 Rhizoma Dioscoreaes 200～240 Fructus Mumes 200～240
Periostracum Cicadae 110～150 Rhizoma Acori Graminei 110～150 Fructus Crataegis 200～240
Radix Glycyrrhizae 50～80
Wherein, the described Rhizoma Atractylodis Macrocephalae is a Rhizoma Atractylodis Macrocephalae (parched), and described Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and described Fructus Crataegi is the parching to brown Fructus Crataegi, and described Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
Above-mentioned raw materials is made the method for medicine of the present invention, comprises the step of following order:
With Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil;
2. distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill;
3. the proportion when getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature;
4. adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours;
5. get supernatant liquid filtering, reclaim ethanol, put cold to there not being the alcohol flavor.
Add right amount of auxiliary materials, granulate, add volatile oil, promptly make oral formulations.
In order to verify therapeutic effect, the present invention has carried out following deep pharmacological testing.
1. acute toxicity test
20 mouse stomach administrations, daily dose 480g/kg observes and did not have any toxic reaction in 7 days, all healthy survival.As calculating with crude drug amount 2.34～2.00 grams by 1～6 years old and 7～12 years old child's average weight per kilogram with body weight for humans, be equivalent to 205～240 times of human metering, point out medicine of the present invention, used clinical dosage is safe.
2. clinical verification
Clinical practice through Hospital Affiliated to Yunan Traditional Chinese Medicine College, Kunming City Children's Hospital, the People's Hospital, Yunnan Province to 101 routine children's infantile malnutrition symptoms has obtained curative effect preferably.It is 76.2% that its cure rate adds obvious effective rate, and total effective rate reaches 97%.Other establishes matched group, virgin Bao oral liquid 40 examples, and details are as follows for relevant treatment situation.
(1) patient's age-sex composition is as shown in table 1.
Table 1.
| Group | Sex | 1～6 year old | 6～12 years old | Subtotal | Add up to |
| Test group (example) | The man | 35 | 14 | 49 | 101 |
| The woman | 34 | 18 | 52 | ||
| Matched group (example) | The man | 17 | 5 | 22 | 40 |
| The woman | 11 | 7 | 18 |
(2) method of administration
The oral granule of the present invention of test group, each 5 grams, three times on the one, one twice-daily of child below 6 years old, be one month the course of treatment.Matched group oral " virgin Bao oral liquid ", each 10 milliliters, three times on the one, one twice-daily of child below 6 years old, be one month the course of treatment.
(3) efficacy evaluation
1. recovery from illness: weight increase, basic near children's's body weight of the same age, various transference cures, it is normal that every index is recovered.
2. produce effects: body weight obviously increases, and various symptoms are obviously improved, and every index is near normal.
3. effective: body weight increases to some extent, and spirit, appetite and various symptom all have improvement, and every inspection index also has improvement.
4. invalid: clinical symptoms, sign, test check index are not seen improvement.
(4) efficacy analysis
After medication course of treatment, relatively the situation of change of body weight and other relevant disease before and after the medication by above-mentioned curative effect determinate standard evaluation curative effect, the results are shown in Table 2～table 8.
The effective percentage of table 2. treatment infantile malnutrition
| Group | Observe routine number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage (%) |
| Test group | 101 | 47 | 30 | 21 | 3 | 97.0 |
| Matched group | 40 | 6 | 4 | 23 | 7 | 82.5 |
Annotate: X
2=7.11 P＜0.05
Main symptom curative effect comparision before and after table 3. medication
| Disease | Group | Observe routine number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage (%) | X 2Value | The P value |
| Appetite | Test group | 96 | 62 | 11 | 21 | 2 | 97.9 | 4.69 | 0.03 |
| Matched group | 38 | 6 | 3 | 24 | 5 | 86.8 | |||
| Complexion | Test group | 99 | 52 | 17 | 25 | 5 | 94.9 | 6.13 | 0.01 |
| Matched group | 39 | 8 | 3 | 20 | 8 | 79.5 | |||
| Stool | Test group | 75 | 50 | 8 | 15 | 2 | 97.3 | 5.42 | 0.019 |
| Matched group | 35 | 6 | 2 | 21 | 6 | 82.8 | |||
| Abdominal distention | Test group | 83 | 59 | 7 | 15 | 2 | 97.6 | 7.86 | 0.005 |
| Matched group | 30 | 7 | 2 | 15 | 6 | 80.0 | |||
| Emotion | Test group | 93 | 58 | 10 | 23 | 2 | 97.8 | 8.15 | 0.004 |
| Matched group | 40 | 10 | 2 | 21 | 7 | 82.5 |
Time card curative effect comparision before and after table 4. medication
| Disease | Group | Observe routine number | Effectively | Invalid | Effective percentage (%) | X 2Value | The P value |
| Lassitude | Test group | 101 | 79 | 22 | 78.2 | 7.21 | 0.01 |
| Matched group | 38 | 21 | 17 | 55.2 | |||
| Rub eyebrow and suck finger | Test group | 100 | 80 | 20 | 80.0 | 4.67 | 0.031 |
Continuous table
| Matched group | 40 | 25 | 15 | 62.5 | |||
| Sleep uneasy night | Test group | 97 | 82 | 15 | 84.5 | 13.69 | 0.0002 |
| Matched group | 37 | 20 | 17 | 51.0 | |||
| The tongue fur body of the tongue | Test group | 96 | 70 | 16 | 81.2 | 0.08 | 0.782 |
| Matched group | 36 | 30 | 6 | 83.3 |
Weight increase situation contrast before and after table 5. medication
| Sex | Group | Observe routine number | X(KG) | S | T | P |
| The man | Test group | 49 | 1.520 | 0.859 | 3.487 | ＜0.01 |
| Matched group | 22 | 0.819 | 0.729 | |||
| The woman | Test group | 52 | 1.457 | 0.932 | 1.151 | ＞0.05 |
| Matched group | 18 | 1.151 | 0.981 |
Hematochrome distribution situation contrast before and after table 6. medication
| Group | Observe routine number | ＜9g | 9-10.9g | 11-11.9g | ≥12g |
| Test group | 101 | 2 | 62 | 22 | 15 |
| Matched group | 40 | 0 | 22 | 10 | 8 |
Annotate: hematochrome relatively before two groups of treatments: X
2=1.58 P＞0.05
Hematochrome situation contrast before and after table 7. medication
| Group | Observe routine number | ＜9g | 9-10.9g | 11-11.9g | ≥12g |
| Test group | 101 | 1 | 1 | 11 | 88 |
| Matched group | 40 | 0 | 3 | 21 | 16 |
Annotate: hematochrome relatively before two groups of treatments: X
2=35.16 P＜0.001
Hematochrome situation contrast before and after table 8. medication
| Group | Observe routine number | Effective routine number | Effective percentage (%) |
| Test group | 86 | 73 | 84.8 |
| Matched group | 32 | 8 | 25.0 |
Annotate: the hematochrome effective percentage relatively before two groups of treatments: X
2=36.12 P＜0.001
Beneficial effect: pharmacological tests shows that the total effective rate that the present invention treats the weak liver-fire type of infantile consumption spleen reaches 97%, and matched group is 82.5%, learns by statistics and handles the difference significance.Any untoward reaction not occurring, is a kind of good medicine of department of pediatrics safely and effectively, is indicating well prospect in medicine.
The specific embodiment
By specific embodiments of the invention given below, can further be well understood to the present invention.But they are not limitation of the invention.
Embodiment 1
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 280, the Rhizoma Atractylodis Macrocephalae 280, Poria 240, HERBA BUPLEURI 240, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 240, the Radix Aucklandiae 80, Fructus Amomi 130, Fructus Hordei Germinatus 350, Spica Prunellae 200, Rhizoma Dioscoreae 240, Fructus Mume 240, Periostracum Cicadae 150, Rhizoma Acori Graminei 150, Fructus Crataegi 240, Radix Glycyrrhizae 80.
With Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil.Distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill.Proportion when getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature.
Adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours.Get supernatant liquid filtering, reclaim ethanol to there not being the alcohol flavor, put coldly, sterilization adds volatile oil, makes the oral liquid finished product.
Embodiment 2
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 250, the Rhizoma Atractylodis Macrocephalae 250, Poria 200, HERBA BUPLEURI 200, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 200, the Radix Aucklandiae 50, Fructus Amomi 90, Fructus Hordei Germinatus 310, Spica Prunellae 150, Rhizoma Dioscoreae 200, Fructus Mume 200, Periostracum Cicadae 110, Rhizoma Acori Graminei 110, Fructus Crataegi 200, Radix Glycyrrhizae 50.
Other production process is identical with embodiment 1.
Embodiment 3
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 264, the Rhizoma Atractylodis Macrocephalae 264, Poria 220, HERBA BUPLEURI 220, the Radix Paeoniae Alba 220, Pericarpium Citri Reticulatae 220, the Radix Aucklandiae 66, Fructus Amomi 110, Fructus Hordei Germinatus 330, Spica Prunellae 176, Rhizoma Dioscoreae 220, Fructus Mume 220, Periostracum Cicadae 132, Rhizoma Acori Graminei 132, Fructus Crataegi 220, Radix Glycyrrhizae 66.
Other production process is identical with embodiment 1.
Embodiment 4
Repeat embodiment 3, following difference is arranged: the Rhizoma Atractylodis Macrocephalae in the raw material is a Rhizoma Atractylodis Macrocephalae (parched), and Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and Fructus Crataegi is the Fructus Crataegi of parching to brown, and Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
Embodiment 5
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 280, the Rhizoma Atractylodis Macrocephalae 280, Poria 240, HERBA BUPLEURI 240, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 240, the Radix Aucklandiae 80, Fructus Amomi 130, Fructus Hordei Germinatus 350, Spica Prunellae 200, Rhizoma Dioscoreae 240, Fructus Mume 240, Periostracum Cicadae 150, Rhizoma Acori Graminei 150, Fructus Crataegi 240, Radix Glycyrrhizae 80.
With Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil.Distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill.Proportion when getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature.
Adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours.Get supernatant liquid filtering, reclaim ethanol, put coldly, add right amount of auxiliary materials, granulate, add volatile oil, promptly make the granule finished product to there not being the alcohol flavor.
Embodiment 6
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 250, the Rhizoma Atractylodis Macrocephalae 250, Poria 200, HERBA BUPLEURI 200, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 200, the Radix Aucklandiae 50, Fructus Amomi 90, Fructus Hordei Germinatus 310, Spica Prunellae 150, Rhizoma Dioscoreae 200, Fructus Mume 200, Periostracum Cicadae 110, Rhizoma Acori Graminei 110, Fructus Crataegi 200, Radix Glycyrrhizae 50.
Other production process is identical with embodiment 5.
Embodiment 7
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 264, the Rhizoma Atractylodis Macrocephalae 264, Poria 220, HERBA BUPLEURI 220, the Radix Paeoniae Alba 220, Pericarpium Citri Reticulatae 220, the Radix Aucklandiae 66, Fructus Amomi 110, Fructus Hordei Germinatus 330, Spica Prunellae 176, Rhizoma Dioscoreae 220, Fructus Mume 220, Periostracum Cicadae 132, Rhizoma Acori Graminei 132, Fructus Crataegi 220, Radix Glycyrrhizae 66.
Other production process is identical with embodiment 5.
Embodiment 8
Repeat embodiment 7, following difference is arranged: the Rhizoma Atractylodis Macrocephalae in the raw material is a Rhizoma Atractylodis Macrocephalae (parched), and Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and Fructus Crataegi is the Fructus Crataegi of parching to brown, and Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
Embodiment 9
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 280, the Rhizoma Atractylodis Macrocephalae 280, Poria 240, HERBA BUPLEURI 240, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 240, the Radix Aucklandiae 80, Fructus Amomi 130, Fructus Hordei Germinatus 350, Spica Prunellae 200, Rhizoma Dioscoreae 240, Fructus Mume 240, Periostracum Cicadae 150, Rhizoma Acori Graminei 150, Fructus Crataegi 240, Radix Glycyrrhizae 80.
With Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil.Distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill.Proportion when getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature.
Adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours.Get supernatant liquid filtering, reclaim ethanol, put coldly, add right amount of auxiliary materials, add volatile oil, promptly make the capsule finished product to there not being the alcohol flavor.
Embodiment 10
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 250, the Rhizoma Atractylodis Macrocephalae 250, Poria 200, HERBA BUPLEURI 200, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 200, the Radix Aucklandiae 50, Fructus Amomi 90, Fructus Hordei Germinatus 310, Spica Prunellae 150, Rhizoma Dioscoreae 200, Fructus Mume 200, Periostracum Cicadae 110, Rhizoma Acori Graminei 110, Fructus Crataegi 200, Radix Glycyrrhizae 50.
Other production process is identical with embodiment 9.
Embodiment 11
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 264, the Rhizoma Atractylodis Macrocephalae 264, Poria 220, HERBA BUPLEURI 220, the Radix Paeoniae Alba 220, Pericarpium Citri Reticulatae 220, the Radix Aucklandiae 66, Fructus Amomi 110, Fructus Hordei Germinatus 330, Spica Prunellae 176, Rhizoma Dioscoreae 220, Fructus Mume 220, Periostracum Cicadae 132, Rhizoma Acori Graminei 132, Fructus Crataegi 220, Radix Glycyrrhizae 66.
Other production process is identical with embodiment 9.
Embodiment 12
Repeat embodiment 11, following difference is arranged: the Rhizoma Atractylodis Macrocephalae in the raw material is a Rhizoma Atractylodis Macrocephalae (parched), and Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and Fructus Crataegi is the Fructus Crataegi of parching to brown, and Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
Embodiment 13
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 280, the Rhizoma Atractylodis Macrocephalae 280, Poria 240, HERBA BUPLEURI 240, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 240, the Radix Aucklandiae 80, Fructus Amomi 130, Fructus Hordei Germinatus 350, Spica Prunellae 200, Rhizoma Dioscoreae 240, Fructus Mume 240, Periostracum Cicadae 150, Rhizoma Acori Graminei 150, Fructus Crataegi 240, Radix Glycyrrhizae 80.
With Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil.Distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill.Proportion when getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature.
Adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours.Get supernatant liquid filtering, reclaim ethanol to there not being the alcohol flavor, put coldly, sterilization adds antiseptic, makes the mixture finished product.
Embodiment 14
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 250, the Rhizoma Atractylodis Macrocephalae 250, Poria 200, HERBA BUPLEURI 200, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 200, the Radix Aucklandiae 50, Fructus Amomi 90, Fructus Hordei Germinatus 310, Spica Prunellae 150, Rhizoma Dioscoreae 200, Fructus Mume 200, Periostracum Cicadae 110, Rhizoma Acori Graminei 110, Fructus Crataegi 200, Radix Glycyrrhizae 50.
Other production process is identical with embodiment 13.
Embodiment 15
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 264, the Rhizoma Atractylodis Macrocephalae 264, Poria 220, HERBA BUPLEURI 220, the Radix Paeoniae Alba 220, Pericarpium Citri Reticulatae 220, the Radix Aucklandiae 66, Fructus Amomi 110, Fructus Hordei Germinatus 330, Spica Prunellae 176, Rhizoma Dioscoreae 220, Fructus Mume 220, Periostracum Cicadae 132, Rhizoma Acori Graminei 132, Fructus Crataegi 220, Radix Glycyrrhizae 66.
Other production process is identical with embodiment 13.
Embodiment 16
Repeat embodiment 15, following difference is arranged: the Rhizoma Atractylodis Macrocephalae in the raw material is a Rhizoma Atractylodis Macrocephalae (parched), and Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and Fructus Crataegi is the Fructus Crataegi of parching to brown, and Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
Embodiment 17
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 280, the Rhizoma Atractylodis Macrocephalae 280, Poria 240, HERBA BUPLEURI 240, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 240, the Radix Aucklandiae 80, Fructus Amomi 130, Fructus Hordei Germinatus 350, Spica Prunellae 200, Rhizoma Dioscoreae 240, Fructus Mume 240, Periostracum Cicadae 150, Rhizoma Acori Graminei 150, Fructus Crataegi 240, Radix Glycyrrhizae 80.
With Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil.Distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill.Proportion when getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature.
Adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours.Get supernatant liquid filtering, reclaim ethanol to there not being the alcohol flavor, put coldly, add right amount of auxiliary materials, add volatile oil, tabletting is promptly made the tablet finished product.
Embodiment 18
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 250, the Rhizoma Atractylodis Macrocephalae 250, Poria 200, HERBA BUPLEURI 200, the Radix Paeoniae Alba 240, Pericarpium Citri Reticulatae 200, the Radix Aucklandiae 50, Fructus Amomi 90, Fructus Hordei Germinatus 310, Spica Prunellae 150, Rhizoma Dioscoreae 200, Fructus Mume 200, Periostracum Cicadae 110, Rhizoma Acori Graminei 110, Fructus Crataegi 200, Radix Glycyrrhizae 50.
Other production process is identical with embodiment 17.
Embodiment 19
Take by weighing raw material by following parts by weight: Radix Pseudostellariae 264, the Rhizoma Atractylodis Macrocephalae 264, Poria 220, HERBA BUPLEURI 220, the Radix Paeoniae Alba 220, Pericarpium Citri Reticulatae 220, the Radix Aucklandiae 66, Fructus Amomi 110, Fructus Hordei Germinatus 330, Spica Prunellae 176, Rhizoma Dioscoreae 220, Fructus Mume 220, Periostracum Cicadae 132, Rhizoma Acori Graminei 132, Fructus Crataegi 220, Radix Glycyrrhizae 66.
Other production process is identical with embodiment 17.
Embodiment 20
Repeat embodiment 19, following difference is arranged: the Rhizoma Atractylodis Macrocephalae in the raw material is a Rhizoma Atractylodis Macrocephalae (parched), and Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and Fructus Crataegi is the Fructus Crataegi of parching to brown, and Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
Claims (8)
1. a medicine of preventing and treating infantile malnutrition is to be made by following materials based on weight: Radix Pseudostellariae 250～280, the Rhizoma Atractylodis Macrocephalae 250～280, Poria 200～240, HERBA BUPLEURI 200～240, the Radix Paeoniae Alba 200～240, Pericarpium Citri Reticulatae 200～240, the Radix Aucklandiae 50～80, Fructus Amomi 90～130, Fructus Hordei Germinatus 310～350 Spica Prunellaes 150～200, Rhizoma Dioscoreae 200～240, Fructus Mume 200～240, Periostracum Cicadae 110～150, Rhizoma Acori Graminei 110～150, Fructus Crataegi 200～240, Radix Glycyrrhizae 50～80.
2. medicine according to claim 1 is characterized in that being made by following materials based on weight: Radix Pseudostellariae 264, the Rhizoma Atractylodis Macrocephalae 264, Poria 220, HERBA BUPLEURI 220, the Radix Paeoniae Alba 220, Pericarpium Citri Reticulatae 220, the Radix Aucklandiae 66, Fructus Amomi 110, Fructus Hordei Germinatus 330, Spica Prunellae 176, Rhizoma Dioscoreae 220, Fructus Mume 220, Periostracum Cicadae 132, Rhizoma Acori Graminei 132, Fructus Crataegi 220, Radix Glycyrrhizae 66.
3. medicine according to claim 1 is characterized in that the described Rhizoma Atractylodis Macrocephalae is a Rhizoma Atractylodis Macrocephalae (parched), and Fructus Hordei Germinatus is Fructus Hordei Germinatus (parched), and Fructus Crataegi is the Fructus Crataegi of parching to brown, and Radix Glycyrrhizae is a Radix Glycyrrhizae Preparata.
4. the preparation method of the medicine of control infantile malnutrition as claimed in claim 1, this method adopts the step of following order:
(1) with Fructus Amomi, Rhizoma Acori Graminei, the Radix Aucklandiae, Pericarpium Citri Reticulatae, the Rhizoma Atractylodis Macrocephalae through water vapour distillation volatile oil;
(2) distillation test residue and Radix Pseudostellariae, Poria, HERBA BUPLEURI, the Radix Paeoniae Alba, Fructus Hordei Germinatus, Spica Prunellae, Rhizoma Dioscoreae, Fructus Mume, Periostracum Cicadae, Fructus Crataegi, Radix Glycyrrhizae water decoct 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour; Merging filtrate leaves standstill;
Proportion when (3) getting supernatant concentration to the heat survey is 1.19～1.21, is cooled to room temperature;
(4) adding ethanol while stirring is 65%～75% to containing the alcohol amount, leaves standstill 4～6 hours;
(5) get supernatant liquid filtering, reclaim ethanol to there not being the alcohol flavor, put coldly, sterilization adds the volatile oil that step (1) is extracted, and makes oral liquid.
5. the preparation method of medicine according to claim 4, it is characterized in that in step (5), putting cold after, add appropriate amount of auxiliary materials, granulate, add the volatile oil that step (1) is extracted, make granule.
6. the preparation method of medicine according to claim 4 is characterized in that the gains of step (3) are further added appropriate amount of auxiliary materials, adds the volatile oil that step (1) is extracted, and makes capsule.
7. the preparation method of medicine according to claim 4 is characterized in that the gains of step (3) are further added an amount of antiseptic, adds the volatile oil that step (1) is extracted, and makes mixture.
8. the preparation method of medicine according to claim 4 is characterized in that the gained of step (3) is further added appropriate amount of auxiliary materials, granulates, and adds the volatile oil that step (1) is extracted, and tabletting is made tablet.
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| CN 200410022272 CN1274353C (en) | 2004-04-07 | 2004-04-07 | Medication for curing children's infantile malnutrition and preparation method |
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| CN105878986A (en) * | 2016-04-09 | 2016-08-24 | 广西智宝科技有限公司 | Decoction for treating infantile malnutrition and preparation method of decoction |
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