CN1273036C - Application os glycerin tributyrate as feed additive - Google Patents
Application os glycerin tributyrate as feed additive Download PDFInfo
- Publication number
- CN1273036C CN1273036C CNB031283683A CN03128368A CN1273036C CN 1273036 C CN1273036 C CN 1273036C CN B031283683 A CNB031283683 A CN B031283683A CN 03128368 A CN03128368 A CN 03128368A CN 1273036 C CN1273036 C CN 1273036C
- Authority
- CN
- China
- Prior art keywords
- feed
- application
- glycerin tributyrate
- tributyrin
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- UYXTWWCETRIEDR-UHFFFAOYSA-N Tributyrin Chemical compound CCCC(=O)OCC(OC(=O)CCC)COC(=O)CCC UYXTWWCETRIEDR-UHFFFAOYSA-N 0.000 title claims abstract description 43
- 239000003674 animal food additive Substances 0.000 title abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000003463 adsorbent Substances 0.000 claims description 2
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 241001465754 Metazoa Species 0.000 abstract description 9
- 206010012735 Diarrhoea Diseases 0.000 abstract description 5
- 230000003115 biocidal effect Effects 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 201000006549 dyspepsia Diseases 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000001788 irregular Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 230000004584 weight gain Effects 0.000 abstract 1
- 235000019786 weight gain Nutrition 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 11
- 241000282898 Sus scrofa Species 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 108010022579 ATP dependent 26S protease Proteins 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 235000016936 Dendrocalamus strictus Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000001842 enterocyte Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
The present invention relates to an application of glycerin tributyrate as a feed additive. The glycerin tributyrate conforms to the characteristics that the molecular formula is C15H26O6, and the molecular weight is 302.37. The present invention has the obvious advantages that the glycerin tributyrate is used for regulating the structure and the functions of the intestinal tracts of ablactated piglets to achieve the effect of preventing the irregular indigestion and the diarrhea of the ablactated piglets; the glycerin tributyrate is used as a growth promoting agent instead of antibiotic to raise the weight gain of animals and the utilization ratio of feed and basically eliminate the residual antibiotic in animal products for producing high-grade nuisanceless animal products.
Description
The present invention relates to the purposes of tributyrin, relate in particular to the purposes of feed additive field.
Intestines and stomach are in disorder behind the weaned piglet has a strong impact on growth in piglets with diarrhoea, has now become " bottleneck " of Swine Production.Need in the production practices to take effective measures and recover the intestines and stomach normal function, overcome the influence of ablactation stress, suppress the generation of grice diarrhoea.In order to solve " bottleneck " problem in this Swine Production, the researcher attempts using the regulation technology of the 26S Proteasome Structure and Function of enteron aisle.For keeping the normal morphology structure of intestinal mucosa behind the weaned piglet, can adopt some trophism or non-nutritive conditioning agent, as glutamine, n-butyric acie, nucleotides, polyamines etc.By using these additives, can promote function of intestinal canal, and then replace antibiotic that this meets and bans use of antibiotic trend in the feed as growth accelerator.
The research that the enteron aisle 26S Proteasome Structure and Function is regulated all is in the starting stage both at home and abroad, and the application study of some adjusting materials such as glutamine (Gln) is more deep, has obtained consistent result.Now illustrated the main energy sources material of glutamine as intestinal mucosa cells, essential by keeping intestinal tissue normal configuration and barrier function.Research for tributyrin at present mainly concentrates on medically, and the research on animal is less, and medical research shows that it has certain biological effect to people's sdenocarcinoma of stomach cell.
The molecular formula C of tributyrin
15H
26O
6, molecular weight 302.37; Structural formula:
The tributyrin generation n-butyric acie that is decomposed in vivo, its active ingredient that plays a role should be n-butyric acie.
Butyric acid is a kind of SCFA, has important biological action.SCFA be generally polysaccharide in the diet in colonic lumen by the product of bacterium glycolysis, mainly comprise acetate, propionic acid and butyric acid, wherein butyric acid is by the main energy source of preferential absorption as colon epithelial cell.Confirm that with in vitro test butyrate can suppress the hyperplasia of colon cancer cell in many bodies, promote its apoptosis and differentiation, it has the protective effect that promotes hyperplasia, suppresses apoptosis to normal enterocyte.Butyric acid is as the important nutrient of mucous membrane of colon, and its physiological action and application clinically come into one's own day by day.N-butyric acie adds the height that can increase intestinal villi in growing-finishing pigs diets.Since the antibiotics feed addictive begin forbidding, and these materials improve animal health and improve production performance by the method for biological therapy, belong to biological or " green " feed addictive category, therefore have a good application prospect.
Tributyrin is the low carbon chain fatty glyceride simultaneously, and the higher carbon chain fatty acid triglyceride absorbs fast, as feed addictive, and particularly to weanling pig, significantly anti diar rhea, raising feed efficiency.
The feed addictive that the purpose of this invention is to provide a kind of weanling pig.
Technical problem to be solved by this invention provides the new purposes of tributyrin, i.e. new application in the feed addictive of weanling pig.
The technical solution adopted for the present invention to solve the technical problems.Tributyrin meets molecular formula C as the application of the feed addictive of weanling pig
15H
26O
6, molecular weight 302.37; Structural formula:
The using method of tributyrin of the present invention, similar with the feed addictive of other kinds, can directly this product be added in the feed; Or this product and adsorbent be mixed and made into pre-mixing agent; The forms such as premix, concentrate feed that also can be mixed and made into other feed addictive or feedstuff are used.The consumption of tributyrin of the present invention according to feed gross weight meter, is 0.1%～2.0%, preferably 0.5%～1.0%.
Tributyrin of the present invention is as the application of feed addictive, and application is a weanling pig.
The advantage that the present invention had is:
1. tributyrin is the short-chain fat acid glyceride, and catabolite is butyric acid and glycerine in the body, and is without any side effects to animal body.
2. tributyrin can significantly promote growth of animal, improve food utilization efficiency as the application of feed addictive.
3. eliminate antibiotic residual in animal product, the nuisanceless animal product of production high-quality.
Below in conjunction with embodiment the present invention is further described.
Carry out the weanling pig test with tributyrin.48 weanling pigs are divided into two groups, three repetitions of every component (hurdle), 8 on every hurdle.Piglet source, age in days, body weight are approaching, the sex unanimity.Two groups of basal diet unanimities, test group is added 0.5% tributyrin, and control group does not add tributyrin.The result is as follows:
Add the influence of tributyrin to the weanling pig growth performance
| Control group | Test group | |
| Daily gain ADG (g/d) expects anharmonic ratio F/G diarrhea rate (%) | 537.4 a 1.46 a 16.0 a | 612 b 1.27 b 9.5 b |
Annotate: the female different persons of colleague's shoulder marking-up represent significant difference (p＜0.05).
The result shows, uses tributyrin of the present invention, and the piglet daily gain improves 13.88%; The material anharmonic ratio reduces by 13.01%; Diarrhea rate reduces by 40.6%.
Claims (1)
1, a kind of purposes of organic compound is characterized in that: tributyrin is as the application of feed addictive, using method be addition according to feed gross weight meter, be 0.5%～1.0%, directly this product is added in the feed of weanling pig; Or this product and adsorbent be mixed and made into pre-mixing agent; Or be mixed and made into premix, the concentrate feed form piglet of feeding with other feed addictive or feedstuff.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031283683A CN1273036C (en) | 2003-07-24 | 2003-07-24 | Application os glycerin tributyrate as feed additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031283683A CN1273036C (en) | 2003-07-24 | 2003-07-24 | Application os glycerin tributyrate as feed additive |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1513347A CN1513347A (en) | 2004-07-21 |
| CN1273036C true CN1273036C (en) | 2006-09-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031283683A Expired - Lifetime CN1273036C (en) | 2003-07-24 | 2003-07-24 | Application os glycerin tributyrate as feed additive |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1273036C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107373094A (en) * | 2017-07-14 | 2017-11-24 | 浙江汇能生物股份有限公司 | A kind of synthesis of tributyrin and the application in feed |
| CN108208341A (en) * | 2017-12-29 | 2018-06-29 | 湖北浩华生物技术有限公司 | Purposes, feed addictive and feed of the fat or oil composition on pig feed additive for fowls is prepared |
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| CN102204633A (en) * | 2011-05-17 | 2011-10-05 | 张婷丽 | Application of glyceryl tripropionate as feed acidifier |
| CN102178062A (en) * | 2011-05-17 | 2011-09-14 | 张婷丽 | Application of glyceroltriacetate as feed acidating agent |
| CN102204634A (en) * | 2011-05-17 | 2011-10-05 | 张婷丽 | Application of triformic acid glyceride as feed acidifier |
| CN103082094B (en) * | 2013-01-31 | 2014-10-29 | 武汉工业学院 | Application of butyrin lactate as feed additive |
| CN103082095B (en) * | 2013-01-31 | 2014-10-29 | 武汉工业学院 | Application of triglyceryl lactate as feed acidifier |
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| CN114041542A (en) * | 2021-12-08 | 2022-02-15 | 成都大帝汉克生物科技有限公司 | Feed additive for promoting piglet gastrointestinal health and preparation method thereof |
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-
2003
- 2003-07-24 CN CNB031283683A patent/CN1273036C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107373094A (en) * | 2017-07-14 | 2017-11-24 | 浙江汇能生物股份有限公司 | A kind of synthesis of tributyrin and the application in feed |
| CN108208341A (en) * | 2017-12-29 | 2018-06-29 | 湖北浩华生物技术有限公司 | Purposes, feed addictive and feed of the fat or oil composition on pig feed additive for fowls is prepared |
| CN108208341B (en) * | 2017-12-29 | 2021-11-30 | 湖北浩华生物技术有限公司 | Application of grease composition in preparation of pig and poultry feed additive, feed additive and feed |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1513347A (en) | 2004-07-21 |
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Address after: 518000 Baoan District, Shenzhen, Gongming, the town of Stone Industrial Zone, No. 1, No. Patentee after: SHENZHEN JINXINNONG TECHNOLOGY CO.,LTD. Address before: 518000 Baoan District, Shenzhen, Gongming, the town of Stone Industrial Zone, No. 1, No. Patentee before: SHENZHEN JINXINNONG FEED Co.,Ltd. |
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